Details for: GSN

Gene ID: 2934

Symbol: GSN

Ensembl ID: ENSG00000148180

Description: gelsolin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 696.4212
    Cell Significance Index: -108.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 405.3132
    Cell Significance Index: -102.8100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 210.4326
    Cell Significance Index: -99.3500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 194.2858
    Cell Significance Index: -78.9300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 178.7085
    Cell Significance Index: -91.9300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 150.1739
    Cell Significance Index: -100.7700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 87.9877
    Cell Significance Index: -108.4900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 82.8495
    Cell Significance Index: -79.1000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 34.8768
    Cell Significance Index: -93.4300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 33.5639
    Cell Significance Index: -103.0900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 31.4998
    Cell Significance Index: -68.9400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 27.3172
    Cell Significance Index: -107.8000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 19.9040
    Cell Significance Index: 134.8600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 11.0241
    Cell Significance Index: 194.8100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 8.9614
    Cell Significance Index: 174.9000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 7.2198
    Cell Significance Index: 206.9600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 7.1645
    Cell Significance Index: 165.5300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 5.1118
    Cell Significance Index: 655.3000
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 4.7847
    Cell Significance Index: 60.2500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 3.3784
    Cell Significance Index: 38.3800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 3.2876
    Cell Significance Index: 47.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.7279
    Cell Significance Index: 374.6100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.4277
    Cell Significance Index: 114.1000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.7371
    Cell Significance Index: 224.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.6399
    Cell Significance Index: 105.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.6392
    Cell Significance Index: 122.1700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6286
    Cell Significance Index: 161.1000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.3141
    Cell Significance Index: 580.9900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3020
    Cell Significance Index: 711.0700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 1.0954
    Cell Significance Index: 55.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9742
    Cell Significance Index: 74.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8602
    Cell Significance Index: 105.7800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6971
    Cell Significance Index: 138.3500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6706
    Cell Significance Index: 120.8800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3766
    Cell Significance Index: 40.9600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.3007
    Cell Significance Index: 4.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2783
    Cell Significance Index: 126.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2658
    Cell Significance Index: 490.1900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2210
    Cell Significance Index: 5.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2072
    Cell Significance Index: 41.5700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2018
    Cell Significance Index: 128.1500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1998
    Cell Significance Index: 38.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1577
    Cell Significance Index: 56.5600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1065
    Cell Significance Index: 163.9900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0954
    Cell Significance Index: 2.7500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0431
    Cell Significance Index: 81.2100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0040
    Cell Significance Index: 0.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0331
    Cell Significance Index: -24.3100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0464
    Cell Significance Index: -28.9700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0585
    Cell Significance Index: -44.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0613
    Cell Significance Index: -45.4000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0677
    Cell Significance Index: -92.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0910
    Cell Significance Index: -2.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1119
    Cell Significance Index: -63.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1791
    Cell Significance Index: -30.5800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2564
    Cell Significance Index: -11.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3010
    Cell Significance Index: -86.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3130
    Cell Significance Index: -45.5000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3576
    Cell Significance Index: -42.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3583
    Cell Significance Index: -75.4600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.4143
    Cell Significance Index: -3.4800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4227
    Cell Significance Index: -49.2600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4410
    Cell Significance Index: -31.1900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4664
    Cell Significance Index: -7.8100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4728
    Cell Significance Index: -24.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5684
    Cell Significance Index: -65.1200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.5911
    Cell Significance Index: -40.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6885
    Cell Significance Index: -71.6900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.7200
    Cell Significance Index: -10.6300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.7600
    Cell Significance Index: -86.7600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.8202
    Cell Significance Index: -38.2400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.8899
    Cell Significance Index: -8.2000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9301
    Cell Significance Index: -73.6600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.0481
    Cell Significance Index: -66.0600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.0989
    Cell Significance Index: -13.1000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.2015
    Cell Significance Index: -72.1300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.2805
    Cell Significance Index: -27.2700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.2980
    Cell Significance Index: -17.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.3751
    Cell Significance Index: -71.4300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.3934
    Cell Significance Index: -44.6300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.4603
    Cell Significance Index: -98.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.5555
    Cell Significance Index: -95.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.5920
    Cell Significance Index: -44.4900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.5990
    Cell Significance Index: -23.9600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.6069
    Cell Significance Index: -98.5200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.6638
    Cell Significance Index: -35.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.9105
    Cell Significance Index: -107.2100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.9848
    Cell Significance Index: -54.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -2.0127
    Cell Significance Index: -105.6800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.0921
    Cell Significance Index: -61.6200
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -2.1067
    Cell Significance Index: -15.1300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -2.1154
    Cell Significance Index: -73.5100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.1979
    Cell Significance Index: -97.2200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.2041
    Cell Significance Index: -80.9100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -2.2088
    Cell Significance Index: -40.8300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -2.2170
    Cell Significance Index: -48.0300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -2.2823
    Cell Significance Index: -58.6700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -2.4875
    Cell Significance Index: -35.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -2.6053
    Cell Significance Index: -69.8100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -2.6161
    Cell Significance Index: -99.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Gelsolin is a 20-kDa protein that belongs to the actin-binding protein family. It is composed of three domains: a proline-rich domain, a calcium-binding domain, and a globular domain. The protein's ability to bind and hydrolyze actin filaments is mediated by its globular domain, which contains two actin-binding sites. Gelsolin's actin-binding properties allow it to regulate actin filament organization, polymerization, and depolymerization, influencing various cellular processes. Gelsolin's unique characteristics include: 1. **Actin-binding properties**: Gelsolin's ability to bind and hydrolyze actin filaments is mediated by its globular domain. 2. **Calcium-dependent**: Gelsolin's activity is regulated by calcium ions, which bind to its calcium-binding domain. 3. **Proline-rich domain**: Gelsolin's proline-rich domain is involved in protein-protein interactions and regulates its activity. 4. **Multifunctional**: Gelsolin's unique properties allow it to regulate various cellular processes, including cell migration, division, and apoptosis. **Pathways and Functions** Gelsolin's involvement in various cellular processes is mediated through its regulation of the actin cytoskeleton. Some of the key pathways and functions include: 1. **Actin filament organization**: Gelsolin regulates actin filament organization, influencing cell shape, migration, and division. 2. **Cell migration**: Gelsolin's regulation of actin filament organization is essential for cell migration, a critical process in development, tissue repair, and disease. 3. **Apoptosis**: Gelsolin's ability to regulate actin filament organization and polymerization is also involved in apoptosis, a critical process in cellular development and tissue homeostasis. 4. **Cytoskeleton regulation**: Gelsolin's regulation of actin filament organization and polymerization is essential for maintaining cytoskeleton homeostasis, influencing cellular behavior and function. 5. **Cell signaling**: Gelsolin's regulation of actin filament organization is also involved in cell signaling, influencing the transmission of signals between cells. **Clinical Significance** Dysregulation of Gelsolin's activity has been implicated in various diseases, including: 1. **Muscular dystrophy**: Gelsolin's dysregulation has been linked to muscular dystrophy, a group of genetic disorders characterized by progressive muscle weakness and degeneration. 2. **Cancer**: Gelsolin's dysregulation has been implicated in cancer, influencing tumor cell migration, invasion, and metastasis. 3. **Neurological disorders**: Gelsolin's dysregulation has been linked to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 4. **Cardiovascular disease**: Gelsolin's dysregulation has been implicated in cardiovascular disease, influencing cardiac muscle contraction and relaxation. In conclusion, Gelsolin is a multifunctional protein that plays a critical role in regulating the actin cytoskeleton, influencing various cellular processes, including cell migration, division, and apoptosis. Its dysregulation has been implicated in various diseases, highlighting the importance of maintaining its activity and function in maintaining cellular homeostasis and preventing disease.

Genular Protein ID: 532905611

Symbol: GELS_HUMAN

Name: Gelsolin

UniProtKB Accession Codes:

P06396 A2A418 A8MUD1 A8MYN7 B7Z373 B7Z5V1 F5H1A8 Q5T0I2 Q8WVV7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 6 CORUM 1 CPTAC 2 CPTC 1 CTD 1 ChEBI 29 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EMBL 13 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 54 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 58 PDBsum 58 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 4 RefSeq 25 SABIO-RK 1 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3020431

Title: Plasma and cytoplasmic gelsolins are encoded by a single gene and contain a duplicated actin-binding domain.

PubMed ID: 3020431

DOI: 10.1038/323455a0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 6092370

Title: Human plasma gelsolin binds to fibronectin.

PubMed ID: 6092370

DOI: 10.1016/s0021-9258(18)90687-3

PubMed ID: 2157434

Title: Amyloid protein in familial amyloidosis (Finnish type) is homologous to gelsolin, an actin-binding protein.

PubMed ID: 2157434

DOI: 10.1016/0006-291x(90)90612-q

PubMed ID: 2153578

Title: Finnish hereditary amyloidosis. Amino acid sequence homology between the amyloid fibril protein and human plasma gelsoline.

PubMed ID: 2153578

DOI: 10.1016/0014-5793(90)80072-q

PubMed ID: 8703941

Title: The plasma and cytoplasmic forms of human gelsolin differ in disulfide structure.

PubMed ID: 8703941

DOI: 10.1021/bi960920n

PubMed ID: 9003812

Title: Functional consequences of disulfide bond formation in gelsolin.

PubMed ID: 9003812

DOI: 10.1016/s0014-5793(96)01439-1

PubMed ID: 10210201

Title: Identification of Tyr438 as the major in vitro c-Src phosphorylation site in human gelsolin: a mass spectrometric approach.

PubMed ID: 10210201

DOI: 10.1110/ps.8.1.234

PubMed ID: 20393563

Title: Functional genomic screen for modulators of ciliogenesis and cilium length.

PubMed ID: 20393563

DOI: 10.1038/nature08895

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 8395021

Title: Structure of gelsolin segment 1-actin complex and the mechanism of filament severing.

PubMed ID: 8395021

DOI: 10.1038/364685a0

PubMed ID: 8599675

Title: Spectroscopic studies of a phosphoinositide-binding peptide from gelsolin: behavior in solutions of mixed solvent and anionic micelles.

PubMed ID: 8599675

DOI: 10.1016/s0006-3495(95)80140-2

PubMed ID: 12460571

Title: The calcium activation of gelsolin: insights from the 3A structure of the G4-G6/actin complex.

PubMed ID: 12460571

DOI: 10.1016/s0022-2836(02)01131-2

PubMed ID: 16466744

Title: Calcium ion exchange in crystalline gelsolin.

PubMed ID: 16466744

DOI: 10.1016/j.jmb.2006.01.026

PubMed ID: 19666512

Title: Ca2+ binding by domain 2 plays a critical role in the activation and stabilization of gelsolin.

PubMed ID: 19666512

DOI: 10.1073/pnas.0812374106

PubMed ID: 23009842

Title: Structural states and dynamics of the D-loop in actin.

PubMed ID: 23009842

DOI: 10.1016/j.bpj.2012.07.030

PubMed ID: 2176481

Title: Gelsolin variant (Asn-187) in familial amyloidosis, Finnish type.

PubMed ID: 2176481

DOI: 10.1042/bj2720827

PubMed ID: 1338910

Title: Gelsolin-derived familial amyloidosis caused by asparagine or tyrosine substitution for aspartic acid at residue 187.

PubMed ID: 1338910

DOI: 10.1038/ng1092-157

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 782
  • Mass: 85698
  • Checksum: 8CEBC52257A160F7
  • Sequence:
    • MAPHRPAPAL LCALSLALCA LSLPVRAATA SRGASQAGAP QGRVPEARPN SMVVEHPEFL 
KAGKEPGLQI WRVEKFDLVP VPTNLYGDFF TGDAYVILKT VQLRNGNLQY DLHYWLGNEC 
SQDESGAAAI FTVQLDDYLN GRAVQHREVQ GFESATFLGY FKSGLKYKKG GVASGFKHVV 
PNEVVVQRLF QVKGRRVVRA TEVPVSWESF NNGDCFILDL GNNIHQWCGS NSNRYERLKA 
TQVSKGIRDN ERSGRARVHV SEEGTEPEAM LQVLGPKPAL PAGTEDTAKE DAANRKLAKL 
YKVSNGAGTM SVSLVADENP FAQGALKSED CFILDHGKDG KIFVWKGKQA NTEERKAALK 
TASDFITKMD YPKQTQVSVL PEGGETPLFK QFFKNWRDPD QTDGLGLSYL SSHIANVERV 
PFDAATLHTS TAMAAQHGMD DDGTGQKQIW RIEGSNKVPV DPATYGQFYG GDSYIILYNY 
RHGGRQGQII YNWQGAQSTQ DEVAASAILT AQLDEELGGT PVQSRVVQGK EPAHLMSLFG 
GKPMIIYKGG TSREGGQTAP ASTRLFQVRA NSAGATRAVE VLPKAGALNS NDAFVLKTPS 
AAYLWVGTGA SEAEKTGAQE LLRVLRAQPV QVAEGSEPDG FWEALGGKAA YRTSPRLKDK 
KMDAHPPRLF ACSNKIGRFV IEEVPGELMQ EDLATDDVML LDTWDQVFVW VGKDSQEEEK 
TEALTSAKRY IETDPANRDR RTPITVVKQG FEPPSFVGWF LGWDDDYWSV DPLDRAMAEL 
AA

Genular Protein ID: 1785533618

Symbol: A0A0A0MS51_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MS51

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 6 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 PANTHER 2 PRIDE 1 PRINTS 1 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 748
  • Mass: 82526
  • Checksum: 01F62E541304E853
  • Sequence:
    • MAEEEALRGN SDPWPNSMVV EHPEFLKAGK EPGLQIWRVE KFDLVPVPTN LYGDFFTGDA 
YVILKTVQLR NGNLQYDLHY WLGNECSQDE SGAAAIFTVQ LDDYLNGRAV QHREVQGFES 
ATFLGYFKSG LKYKKGGVAS GFKHVVPNEV VVQRLFQVKG RRVVRATEVP VSWESFNNGD 
CFILDLGNNI HQWCGSNSNR YERLKATQVS KGIRDNERSG RARVHVSEEG TEPEAMLQVL 
GPKPALPAGT EDTAKEDAAN RKLAKLYKVS NGAGTMSVSL VADENPFAQG ALKSEDCFIL 
DHGKDGKIFV WKGKQANTEE RKAALKTASD FITKMDYPKQ TQVSVLPEGG ETPLFKQFFK 
NWRDPDQTDG LGLSYLSSHI ANVERVPFDA ATLHTSTAMA AQHGMDDDGT GQKQIWRIEG 
SNKVPVDPAT YGQFYGGDSY IILYNYRHGG RQGQIIYNWQ GAQSTQDEVA ASAILTAQLD 
EELGGTPVQS RVVQGKEPAH LMSLFGGKPM IIYKGGTSRE GGQTAPASTR LFQVRANSAG 
ATRAVEVLPK AGALNSNDAF VLKTPSAAYL WVGTGASEAE KTGAQELLRV LRAQPVQVAE 
GSEPDGFWEA LGGKAAYRTS PRLKDKKMDA HPPRLFACSN KIGRFVIEEV PGELMQEDLA 
TDDVMLLDTW DQVFVWVGKD SQEEEKTEAL TSAKRYIETD PANRDRRTPI TVVKQGFEPP 
SFVGWFLGWD DDYWSVDPLD RAMAELAA

Genular Protein ID: 1808108869

Symbol: A0A0A0MT01_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MT01

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 6 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 PANTHER 2 PRIDE 1 PRINTS 1 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 767
  • Mass: 84745
  • Checksum: 0AFF281D6076CC6F
  • Sequence:
    • MNTGLTRLLW PSWLPDGDMS HPQPELFLFP KAQPNSMVVE HPEFLKAGKE PGLQIWRVEK 
FDLVPVPTNL YGDFFTGDAY VILKTVQLRN GNLQYDLHYW LGNECSQDES GAAAIFTVQL 
DDYLNGRAVQ HREVQGFESA TFLGYFKSGL KYKKGGVASG FKHVVPNEVV VQRLFQVKGR 
RVVRATEVPV SWESFNNGDC FILDLGNNIH QWCGSNSNRY ERLKATQVSK GIRDNERSGR 
ARVHVSEEGT EPEAMLQVLG PKPALPAGTE DTAKEDAANR KLAKLYKVSN GAGTMSVSLV 
ADENPFAQGA LKSEDCFILD HGKDGKIFVW KGKQANTEER KAALKTASDF ITKMDYPKQT 
QVSVLPEGGE TPLFKQFFKN WRDPDQTDGL GLSYLSSHIA NVERVPFDAA TLHTSTAMAA 
QHGMDDDGTG QKQIWRIEGS NKVPVDPATY GQFYGGDSYI ILYNYRHGGR QGQIIYNWQG 
AQSTQDEVAA SAILTAQLDE ELGGTPVQSR VVQGKEPAHL MSLFGGKPMI IYKGGTSREG 
GQTAPASTRL FQVRANSAGA TRAVEVLPKA GALNSNDAFV LKTPSAAYLW VGTGASEAEK 
TGAQELLRVL RAQPVQVAEG SEPDGFWEAL GGKAAYRTSP RLKDKKMDAH PPRLFACSNK 
IGRFVIEEVP GELMQEDLAT DDVMLLDTWD QVFVWVGKDS QEEEKTEALT SAKRYIETDP 
ANRDRRTPIT VVKQGFEPPS FVGWFLGWDD DYWSVDPLDR AMAELAA

Genular Protein ID: 3004336481

Symbol: B7Z4U6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z4U6

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 5 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 1 InterPro 3 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 2 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 689
  • Mass: 75752
  • Checksum: 22FEF22DD9D9B51D
  • Sequence:
    • MAEEEALRGN SDPWPNSMVV EHPEFLKAGK EPGLQIWRVE KFDLVPVPTN LYGDFFTGDA 
YVILKTVQLR NGNLQYDLHY WLGNECSQDE SGAAAIFTVQ LDDYLNGRAV QHREVQGFES 
ATFLGYFKSG LKYKKGGVAS GFKHVVPNEV VVQRLFQVKG RRVVRATEVP VSWESFNNGD 
CFILDLGNNI HQWCGSNSNR YERLKATQVS KGIRDNERSG RARVHVSEEG TEPEAMLQVL 
GPKPALPAGT EDTAKEDAAN HKLAKLYKVS NGAGTMSVSL VADENPFAQG ALKSEDCFIL 
DHGKDGKIFV WKGKQANTEE RKAALKTASD FITKMDYPKQ TQVSVLPEGG ETPLFKQFFK 
NWRDPDQTDG LGLSYLSSHI ANVERVPFDA ATLHTSTAMA AQHGMDDDGT GQKQIWRIEG 
SNKVPVDPAT YGQFYGGDSY IILYNYRHGG RQGQIIYNWQ GAQSTQDEVA ASAILTAQLD 
EELGGTPVQS RVVQGKEPAH LMSLFGGKPM IIYKGGTSRE GGQTAPASTR LFQVRANSAG 
ATRAVEVLPK AGALNSNDAF VLKTPSAAYL WVGTGASEAE KTGAQELLRV LRAQPVQVAE 
GSEPDGFWEA LGGKAAYRTS PRLKDKKMDA HPPRLFACSN KIGRFVIEEV PGELMQEDLA 
TDDVMLLDTW DQVFVWVGKD SQEEEKTEA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.