Details for: GYPC

Gene ID: 2995

Symbol: GYPC

Ensembl ID: ENSG00000136732

Description: glycophorin C (Gerbich blood group)

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.28
    Marker Score: 32494
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 3.03
    Marker Score: 5414
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.93
    Marker Score: 3060
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.85
    Marker Score: 1424
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.74
    Marker Score: 144719
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.73
    Marker Score: 6664
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.71
    Marker Score: 8545
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.62
    Marker Score: 7359
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.62
    Marker Score: 3712
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.62
    Marker Score: 10725
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.6
    Marker Score: 34350
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 2.54
    Marker Score: 1839
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.54
    Marker Score: 1545
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.51
    Marker Score: 2790
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.51
    Marker Score: 10757.5
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.48
    Marker Score: 7251.5
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.47
    Marker Score: 4301
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.46
    Marker Score: 1778
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 2.43
    Marker Score: 4176
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.43
    Marker Score: 15546
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 2.42
    Marker Score: 1826
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.4
    Marker Score: 6288
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.39
    Marker Score: 7085.5
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.32
    Marker Score: 9992
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.28
    Marker Score: 58418
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.27
    Marker Score: 1248
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.26
    Marker Score: 2114
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.2
    Marker Score: 948
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.14
    Marker Score: 1824
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 2.13
    Marker Score: 1899
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.13
    Marker Score: 2055.5
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.1
    Marker Score: 13631
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.08
    Marker Score: 1635
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.08
    Marker Score: 645
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 2.07
    Marker Score: 1334
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 2.07
    Marker Score: 2290
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.06
    Marker Score: 1210
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.06
    Marker Score: 1736
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.05
    Marker Score: 2062
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 2.04
    Marker Score: 1386
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.04
    Marker Score: 1173
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.04
    Marker Score: 1811
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.03
    Marker Score: 2993
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.03
    Marker Score: 22814
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 2.02
    Marker Score: 647.5
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.01
    Marker Score: 838
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2
    Marker Score: 2757
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.99
    Marker Score: 5054
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1.98
    Marker Score: 436
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.98
    Marker Score: 445
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.98
    Marker Score: 975
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.94
    Marker Score: 588
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.93
    Marker Score: 677
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.92
    Marker Score: 1452
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.92
    Marker Score: 1684
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.9
    Marker Score: 657.5
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.89
    Marker Score: 21930
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.89
    Marker Score: 469.5
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.88
    Marker Score: 1369.5
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.88
    Marker Score: 1560
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.88
    Marker Score: 1184
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.87
    Marker Score: 469.5
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.87
    Marker Score: 9178
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.87
    Marker Score: 1368
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.86
    Marker Score: 1833
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.86
    Marker Score: 647.5
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 1.85
    Marker Score: 600
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.84
    Marker Score: 1967
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.84
    Marker Score: 590
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.83
    Marker Score: 2159.5
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 1.83
    Marker Score: 414
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.82
    Marker Score: 1894
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.8
    Marker Score: 1689
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.8
    Marker Score: 1939
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.79
    Marker Score: 3509
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.78
    Marker Score: 585
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 1.76
    Marker Score: 972
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 1.75
    Marker Score: 444
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.75
    Marker Score: 4118
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.74
    Marker Score: 1247
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.74
    Marker Score: 421
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.73
    Marker Score: 1256
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.73
    Marker Score: 1628
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 1.72
    Marker Score: 456
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.71
    Marker Score: 407
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.71
    Marker Score: 879
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 1.71
    Marker Score: 746
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.69
    Marker Score: 963
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.69
    Marker Score: 1439
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.69
    Marker Score: 1815
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.68
    Marker Score: 1380
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.68
    Marker Score: 57202
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.66
    Marker Score: 580
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.66
    Marker Score: 2206
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.66
    Marker Score: 1041
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.65
    Marker Score: 583
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.63
    Marker Score: 1910.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.63
    Marker Score: 2674
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.62
    Marker Score: 460
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.61
    Marker Score: 1370

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - Gene name: GYPC - Ensembl ID: ENSG00000136732 - Protein: GLPC_HUMAN - Cellular location: Cell surface - Pathway: Cell surface interactions at the vascular wall, Cortical cytoskeleton, Hemostasis, Membrane, Plasma membrane, Protein binding **Pathways and functions:** - Cell surface interactions: Glycophorin C is expressed on the surface of mature T cells, naive thymus-derived CD8-positive, alpha-beta T cell, erythroid progenitor cell, DN3 thymocyte, mature alpha-beta T cell, central memory CD8-positive, alpha-beta T cell, mature gamma-delta T cell, CD8-positive, alpha-beta memory T cell, CD45RO-positive, CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell, pro-T cell. It plays a role in cell-cell interactions and leukocyte adhesion. - Cortical cytoskeleton: Glycophorin C is also expressed on the surface of the cortical cytoskeleton. It is involved in cell signaling and cell migration. - Hemostasis: Glycophorin C is a component of the blood protein complex factor VIII, which is involved in blood clotting. - Membrane: Glycophorin C is a transmembrane protein that is involved in cell adhesion and cell signaling. **Clinical significance:** - Mutations in the GYPC gene have been linked to human immunodeficiency. - Glycophorin C is a potential therapeutic target for immune disorders, such as immunodeficiency and cancer.

Genular Protein ID: 3440578368

Symbol: GLPC_HUMAN

Name: Glycophorin-C

UniProtKB Accession Codes:

P04921 B2R522 Q53SV9 Q92642

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CORUM 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 16 EPD 1 Ensembl 3 EvolutionaryTrace 1 GO 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2416746

Title: Isolation of cDNA clones and complete amino acid sequence of human erythrocyte glycophorin C.

PubMed ID: 2416746

DOI: 10.1016/s0021-9258(17)42458-6

PubMed ID: 3606576

Title: Human erythrocyte membrane sialoglycoprotein beta. The cDNA sequence suggests the absence of a cleaved N-terminal signal sequence.

PubMed ID: 3606576

DOI: 10.1042/bj2430277

PubMed ID: 3544149

Title: Structure of human erythrocyte glycophorin C deduced from cDNA analysis.

PubMed ID: 3544149

DOI: 10.1016/s0338-4535(86)80020-4

PubMed ID: 3595602

Title: Gerbich blood group deficiency of the Ge:-1,-2,-3 and Ge:-1,-2,3 types. Immunochemical study and genomic analysis with cDNA probes.

PubMed ID: 3595602

DOI: 10.1111/j.1432-1033.1987.tb11478.x

PubMed ID: 2349119

Title: An ubiquitous isoform of glycophorin C is produced by alternative splicing.

PubMed ID: 2349119

DOI: 10.1093/nar/18.10.3076

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3571235

Title: Glycophorins B and C from human erythrocyte membranes. Purification and sequence analysis.

PubMed ID: 3571235

DOI: 10.1016/s0021-9258(18)45646-3

PubMed ID: 4074499

Title: A revision of the N-terminal structure of sialoglycoprotein D (glycophorin C) from human erythrocyte membranes.

PubMed ID: 4074499

DOI: 10.1515/bchm3.1985.366.2.1067

PubMed ID: 7106126

Title: N-terminal amino acid sequence of sialoglycoprotein D (glycophorin C) from human erythrocyte membranes.

PubMed ID: 7106126

DOI: 10.1111/j.1432-1033.1982.tb06650.x

PubMed ID: 2776757

Title: Structural homology between glycophorins C and D of human erythrocytes.

PubMed ID: 2776757

DOI: 10.1111/j.1432-1033.1989.tb21093.x

PubMed ID: 2584223

Title: Structure of the promoter region and tissue specificity of the human glycophorin C gene.

PubMed ID: 2584223

DOI: 10.1016/s0021-9258(19)47077-4

PubMed ID: 2818576

Title: Rearrangements of the red-cell membrane glycophorin C (sialoglycoprotein beta) gene. A further study of alterations in the glycophorin C gene.

PubMed ID: 2818576

DOI: 10.1042/bj2620047

PubMed ID: 2917976

Title: Human erythrocyte glycophorin C. Gene structure and rearrangement in genetic variants.

PubMed ID: 2917976

DOI: 10.1016/s0021-9258(19)84916-5

PubMed ID: 12469115

Title: Plasmodium falciparum erythrocyte invasion through glycophorin C and selection for Gerbich negativity in human populations.

PubMed ID: 12469115

DOI: 10.1038/nm807

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 1991173

Title: Molecular characterization of erythrocyte glycophorin C variants.

PubMed ID: 1991173

PubMed ID: 1413665

Title: Point mutation in the glycophorin C gene results in the expression of the blood group antigen Dha.

PubMed ID: 1413665

DOI: 10.1111/j.1423-0410.1992.tb01220.x

PubMed ID: 8219208

Title: A point mutation in the GYPC gene results in the expression of the blood group Ana antigen on glycophorin D but not on glycophorin C: further evidence that glycophorin D is a product of the GYPC gene.

PubMed ID: 8219208

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 128
  • Mass: 13811
  • Checksum: C9C654009A5642D5
  • Sequence:
    • MWSTRSPNST AWPLSLEPDP GMASASTTMH TTTIAEPDPG MSGWPDGRME TSTPTIMDIV 
VIAGVIAAVA IVLVSLLFVM LRYMYRHKGT YHTNEAKGTE FAESADAALQ GDPALQDAGD 
SSRKEYFI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.