Details for: S100A4

Gene ID: 6275

Symbol: S100A4

Ensembl ID: ENSG00000196154

Description: S100 calcium binding protein A4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 293.8052
    Cell Significance Index: -45.7000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 240.5888
    Cell Significance Index: -99.1100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 238.3267
    Cell Significance Index: -60.4500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 229.0668
    Cell Significance Index: -93.0600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 194.6210
    Cell Significance Index: -91.8900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 190.8492
    Cell Significance Index: -98.1700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 98.8329
    Cell Significance Index: -94.3600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 58.1124
    Cell Significance Index: -71.6500
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 38.6020
    Cell Significance Index: 160.6600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 27.6742
    Cell Significance Index: -85.0000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 24.6917
    Cell Significance Index: -54.0400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 24.3807
    Cell Significance Index: 450.6200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 23.9049
    Cell Significance Index: -94.3300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 14.9345
    Cell Significance Index: 438.6100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 5.5121
    Cell Significance Index: 355.6200
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 4.1260
    Cell Significance Index: 12.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.9995
    Cell Significance Index: 720.9900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.6790
    Cell Significance Index: 105.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.8190
    Cell Significance Index: 346.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.6691
    Cell Significance Index: 1457.6400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.3950
    Cell Significance Index: 22.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.4122
    Cell Significance Index: 139.7000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1683
    Cell Significance Index: 190.0100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.0801
    Cell Significance Index: 21.0800
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.4899
    Cell Significance Index: 3.2500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.4692
    Cell Significance Index: 7.2600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3419
    Cell Significance Index: 17.2800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2999
    Cell Significance Index: 132.5900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1724
    Cell Significance Index: 130.4800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0848
    Cell Significance Index: 10.8700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0614
    Cell Significance Index: 1.0900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0589
    Cell Significance Index: 2.0700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0382
    Cell Significance Index: 3.9000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0372
    Cell Significance Index: 7.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0081
    Cell Significance Index: 14.8600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0071
    Cell Significance Index: 13.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0064
    Cell Significance Index: 9.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0373
    Cell Significance Index: -5.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0429
    Cell Significance Index: -58.2900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0466
    Cell Significance Index: -34.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0728
    Cell Significance Index: -53.9000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0911
    Cell Significance Index: -57.8300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1146
    Cell Significance Index: -71.5400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1488
    Cell Significance Index: -1.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1525
    Cell Significance Index: -86.0300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1627
    Cell Significance Index: -2.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1654
    Cell Significance Index: -8.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1796
    Cell Significance Index: -8.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1922
    Cell Significance Index: -87.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2325
    Cell Significance Index: -66.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.2613
    Cell Significance Index: -51.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.2731
    Cell Significance Index: -97.9700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2782
    Cell Significance Index: -35.9500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3593
    Cell Significance Index: -9.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3969
    Cell Significance Index: -83.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4078
    Cell Significance Index: -47.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.4320
    Cell Significance Index: -73.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4335
    Cell Significance Index: -12.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4381
    Cell Significance Index: -63.6900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4492
    Cell Significance Index: -52.9800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4492
    Cell Significance Index: -18.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4565
    Cell Significance Index: -9.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.4784
    Cell Significance Index: -95.9600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.4931
    Cell Significance Index: -7.0200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5245
    Cell Significance Index: -13.4000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.5368
    Cell Significance Index: -24.3300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.6222
    Cell Significance Index: -37.3600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.6910
    Cell Significance Index: -18.4500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6979
    Cell Significance Index: -79.9600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7548
    Cell Significance Index: -39.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.7654
    Cell Significance Index: -52.9300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.8293
    Cell Significance Index: -94.6600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.8603
    Cell Significance Index: -14.8300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.8719
    Cell Significance Index: -90.7900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.9387
    Cell Significance Index: -69.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.9689
    Cell Significance Index: -74.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0593
    Cell Significance Index: -64.9500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -1.0841
    Cell Significance Index: -76.6700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.1530
    Cell Significance Index: -91.3200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -1.2680
    Cell Significance Index: -55.1400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -1.3094
    Cell Significance Index: -7.1400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.4526
    Cell Significance Index: -91.5600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.4784
    Cell Significance Index: -99.4100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.5693
    Cell Significance Index: -96.4600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.6216
    Cell Significance Index: -34.5400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.7623
    Cell Significance Index: -49.2500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.8234
    Cell Significance Index: -102.3200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.8409
    Cell Significance Index: -85.8300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -1.8438
    Cell Significance Index: -36.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.8992
    Cell Significance Index: -60.8300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -2.0142
    Cell Significance Index: -42.1600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -2.0499
    Cell Significance Index: -107.6300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.2310
    Cell Significance Index: -81.9000
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -2.4790
    Cell Significance Index: -25.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.4909
    Cell Significance Index: -110.1800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.5209
    Cell Significance Index: -74.2500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -2.5991
    Cell Significance Index: -17.6100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -2.7170
    Cell Significance Index: -65.8100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -2.7571
    Cell Significance Index: -96.5900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -2.7677
    Cell Significance Index: -96.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** S100A4 is a small, acidic protein with a molecular weight of approximately 16 kDa. It is highly expressed in various cell types, including immune cells, such as natural killer (NK) cells, T-regulatory cells, and monocytes. S100A4 is also found in epithelial cells, where it is involved in the regulation of cell growth, differentiation, and survival. The protein is characterized by its ability to bind calcium ions, which is essential for its biological activity. **Pathways and Functions:** S100A4 is involved in several cellular pathways, including: 1. **Epithelial to Mesenchymal Transition (EMT):** S100A4 has been shown to promote EMT, a process by which epithelial cells undergo a phenotypic transformation into mesenchymal cells. This process is essential for various physiological and pathological processes, including wound healing, cancer progression, and immune responses. 2. **Immune Cell Regulation:** S100A4 is expressed in various immune cells, including NK cells, T-regulatory cells, and monocytes. It plays a crucial role in regulating the function of these cells, including their proliferation, differentiation, and survival. 3. **Chemoattractant Activity:** S100A4 has been shown to have chemoattractant activity, which is essential for the migration of immune cells to sites of inflammation. 4. **Rage Receptor Binding:** S100A4 binds to the receptor for activated platelets (RAGE), which is a key receptor involved in the regulation of immune responses. **Clinical Significance:** S100A4 has been implicated in various immune-related disorders, including: 1. **Cancer:** Elevated levels of S100A4 have been observed in various types of cancer, including breast, lung, and colon cancer. It is thought to play a role in the promotion of cancer progression and metastasis. 2. **Autoimmune Diseases:** S100A4 has been implicated in various autoimmune diseases, including rheumatoid arthritis, lupus, and multiple sclerosis. It is thought to play a role in the regulation of immune responses and the promotion of inflammation. 3. **Infectious Diseases:** S100A4 has been shown to be involved in the regulation of immune responses to infections, including tuberculosis and HIV. 4. **Cardiovascular Diseases:** Elevated levels of S100A4 have been observed in various cardiovascular diseases, including atherosclerosis and heart failure. In conclusion, S100A4 is a multifunctional protein that plays a crucial role in various cellular processes, including immune regulation, cell cycle progression, and differentiation. Its clinical significance is evident in various immune-related disorders, including cancer, autoimmune diseases, infectious diseases, and cardiovascular diseases. Further research is needed to fully understand the role of S100A4 in these disorders and to explore its potential as a biomarker or therapeutic target.

Genular Protein ID: 1541478877

Symbol: S10A4_HUMAN

Name: Protein S100-A4

UniProtKB Accession Codes:

P26447 A8K7R8 D3DV46 Q6ICP8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 14 Ensembl 4 EvolutionaryTrace 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 17 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SASBDB 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1384693

Title: S100 alpha, CAPL, and CACY: molecular cloning and expression analysis of three calcium-binding proteins from human heart.

PubMed ID: 1384693

DOI: 10.1021/bi00157a012

PubMed ID: 8341667

Title: Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E.

PubMed ID: 8341667

DOI: 10.1073/pnas.90.14.6547

PubMed ID: 1329089

Title: Transcriptional analysis of the mts1 gene with specific reference to 5' flanking sequences.

PubMed ID: 1329089

DOI: 10.1073/pnas.89.19.9146

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1482346

Title: Calcyclin and calvasculin exist in human platelets.

PubMed ID: 1482346

DOI: 10.1016/0006-291x(92)90216-8

PubMed ID: 11836260

Title: Liprin beta 1, a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins, is a new target for the metastasis-associated protein S100A4 (Mts1).

PubMed ID: 11836260

DOI: 10.1074/jbc.m110976200

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 16707441

Title: The S100A4 metastasis factor regulates cellular motility via a direct interaction with myosin-IIA.

PubMed ID: 16707441

DOI: 10.1158/0008-5472.can-05-3087

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23024279

Title: The unique cytoplasmic domain of human FcgammaRIIIA regulates receptor-mediated function.

PubMed ID: 23024279

DOI: 10.4049/jimmunol.1200704

PubMed ID: 23752197

Title: S100A4 interacts with p53 in the nucleus and promotes p53 degradation.

PubMed ID: 23752197

DOI: 10.1038/onc.2013.213

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26654597

Title: A new role for PGRP-S (Tag7) in immune defense: lymphocyte migration is induced by a chemoattractant complex of Tag7 with Mts1.

PubMed ID: 26654597

DOI: 10.1080/15384101.2015.1104440

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30713770

Title: Tag7-Mts1 Complex Induces Lymphocytes Migration via CCR5 and CXCR3 Receptors.

PubMed ID: 30713770

PubMed ID: 12379109

Title: Solution structure of human Mts1 (S100A4) as determined by NMR spectroscopy.

PubMed ID: 12379109

DOI: 10.1021/bi020365r

PubMed ID: 28669632

Title: Regulation of the Equilibrium between Closed and Open Conformations of Annexin A2 by N-Terminal Phosphorylation and S100A4-Binding.

PubMed ID: 28669632

DOI: 10.1016/j.str.2017.06.001

PubMed ID: 32442400

Title: Structure Determination of the Transactivation Domain of p53 in Complex with S100A4Using Annexin A2 as a Crystallization Chaperone.

PubMed ID: 32442400

DOI: 10.1016/j.str.2020.05.001

Sequence Information:

  • Length: 101
  • Mass: 11729
  • Checksum: 286D2B7B07EDB562
  • Sequence:
    • MACPLEKALD VMVSTFHKYS GKEGDKFKLN KSELKELLTR ELPSFLGKRT DEAAFQKLMS 
NLDSNRDNEV DFQEYCVFLS CIAMMCNEFF EGFPDKQPRK K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.