Details for: XRCC6

Gene ID: 2547

Symbol: XRCC6

Ensembl ID: ENSG00000196419

Description: X-ray repair cross complementing 6

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.69
    Marker Score: 3861
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.62
    Marker Score: 30513
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.55
    Marker Score: 33644
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.54
    Marker Score: 2645
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.53
    Marker Score: 16463
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.49
    Marker Score: 24645
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.44
    Marker Score: 5094.5
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.42
    Marker Score: 128071
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.41
    Marker Score: 9872
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.38
    Marker Score: 3375
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 2.37
    Marker Score: 873
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.34
    Marker Score: 3969
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.33
    Marker Score: 3828
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.33
    Marker Score: 6350
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.29
    Marker Score: 2762
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.28
    Marker Score: 9782
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.26
    Marker Score: 7136.5
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.26
    Marker Score: 2184
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.24
    Marker Score: 5475.5
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.24
    Marker Score: 2375
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.22
    Marker Score: 3536
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.22
    Marker Score: 8720
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.21
    Marker Score: 19082
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.21
    Marker Score: 2222
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.2
    Marker Score: 2579
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.2
    Marker Score: 8482
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.2
    Marker Score: 9471
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.19
    Marker Score: 523
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.18
    Marker Score: 1586
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.17
    Marker Score: 2042
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.17
    Marker Score: 5100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.12
    Marker Score: 21382
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.12
    Marker Score: 1332
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.12
    Marker Score: 1415
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.11
    Marker Score: 2257.5
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.11
    Marker Score: 2255
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.11
    Marker Score: 3771
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.11
    Marker Score: 3246
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.11
    Marker Score: 2229.5
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.11
    Marker Score: 15686
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.1
    Marker Score: 4122
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.07
    Marker Score: 5819
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.06
    Marker Score: 1720
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.06
    Marker Score: 3643
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 2.05
    Marker Score: 2465
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.05
    Marker Score: 3850
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.05
    Marker Score: 1483
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 2.04
    Marker Score: 1967.5
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 2.04
    Marker Score: 2710
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.04
    Marker Score: 1735
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 2.03
    Marker Score: 1266
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.03
    Marker Score: 7507
  • Cell Name: oocyte (CL0000023)
    Fold Change: 2.02
    Marker Score: 499
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.02
    Marker Score: 1583
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.02
    Marker Score: 1150
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.01
    Marker Score: 1883
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.01
    Marker Score: 5949
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2
    Marker Score: 2359
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.99
    Marker Score: 2169
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.99
    Marker Score: 5407
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.98
    Marker Score: 20093
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.97
    Marker Score: 2907
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.97
    Marker Score: 487
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.97
    Marker Score: 794
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.96
    Marker Score: 67987.5
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.96
    Marker Score: 1839
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.95
    Marker Score: 1177
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.95
    Marker Score: 4092
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.95
    Marker Score: 66179
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.94
    Marker Score: 425
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.94
    Marker Score: 1305
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.93
    Marker Score: 556
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.93
    Marker Score: 1129
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.92
    Marker Score: 11401
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.92
    Marker Score: 1688
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.92
    Marker Score: 1058
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.92
    Marker Score: 5303
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.9
    Marker Score: 2048
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.9
    Marker Score: 3307
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.89
    Marker Score: 25378
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.89
    Marker Score: 1428
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.88
    Marker Score: 1103
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.87
    Marker Score: 936
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.87
    Marker Score: 1353
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.87
    Marker Score: 11955
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.87
    Marker Score: 4551
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.86
    Marker Score: 2403
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 1.86
    Marker Score: 844
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.85
    Marker Score: 976
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.85
    Marker Score: 535
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 1.85
    Marker Score: 1398
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.85
    Marker Score: 655
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.85
    Marker Score: 4394
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.85
    Marker Score: 3600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.84
    Marker Score: 1940
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.84
    Marker Score: 902
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 1.84
    Marker Score: 1185
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.84
    Marker Score: 3737
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.84
    Marker Score: 1635
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.84
    Marker Score: 1209

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Other Information

**Key characteristics:** * XRCC6 is a member of the XRCC family of DNA repair proteins. * It is expressed in a variety of cell types, including oogonial cells, blood cells, mesodermal cells, erythroid progenitor cells, interstitial cells of the ovary, mature T cells, epithelial cells of the nephron, mature alpha-beta T cells, pro-T cells, CD8-alpha-alpha-positive T cells, and alpha-beta intraepithelial T cells. * It is a highly conserved protein with a predicted molecular weight of approximately 115 kDa. * It contains a conserved catalytic domain that is involved in DNA repair. **Pathways and functions:** * XRCC6 is involved in the repair of DNA double-strand breaks (DSB) induced by various agents, including ionizing radiation, viruses, and certain chemicals. * It is a key component of the innate immune response to viral infection. * It is activated by viral proteins, such as HIV-1 and HSV-1, through the binding of viral glycoproteins to its catalytic domain. * Once activated, XRCC6 forms a heterodimeric complex with other DNA repair proteins, including BRCA1 and BRCA2. * This complex recruits other repair proteins to the site of DNA damage, where it facilitates the repair of the break. **Clinical significance:** * Mutations in XRCC6 have been linked to an increased susceptibility to viral infections, including HIV and hepatitis C virus (HCV). * XRCC6 inhibitors are being investigated as potential therapeutics for cancer and viral infections. * Understanding the role of XRCC6 in DNA repair and viral infection has important implications for the development of new strategies for cancer immunotherapy and the treatment of viral infections.

Genular Protein ID: 2915618585

Symbol: XRCC6_HUMAN

Name: X-ray repair cross-complementing protein 6

UniProtKB Accession Codes:

P12956 B1AHC8 Q6FG89 Q9UCQ2 Q9UCQ3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EC 2 ELM 1 EMBL 14 EMDB 32 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 47 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 48 PDBsum 37 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 3 SAM 1 SASBDB 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2917966

Title: Cloning and characterization of a cDNA that encodes a 70-kDa novel human thyroid autoantigen.

PubMed ID: 2917966

DOI: 10.1016/s0021-9258(19)84898-6

PubMed ID: 2466842

Title: Molecular cloning of cDNA encoding the p70 (Ku) lupus autoantigen.

PubMed ID: 2466842

DOI: 10.1016/s0021-9258(18)83697-3

PubMed ID: 1608402

Title: Nucleotide sequence and genomic structure analyses of the p70 subunit of the human Ku autoantigen: evidence for a family of genes encoding Ku (p70)-related polypeptides.

PubMed ID: 1608402

DOI: 10.1007/bf00419754

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1537839

Title: Identification of proteins binding to interferon-inducible transcriptional enhancers in hematopoietic cells.

PubMed ID: 1537839

DOI: 10.1016/s0021-9258(18)42866-9

PubMed ID: 8605992

Title: Non-histone protein 1 (NHP1) is a member of the Ku protein family which is upregulated in differentiating mouse myoblasts and human promyelocytes.

PubMed ID: 8605992

DOI: 10.1016/0014-5793(96)00189-5

PubMed ID: 8621488

Title: The interaction between Ku antigen and REF1 protein mediates negative gene regulation by extracellular calcium.

PubMed ID: 8621488

DOI: 10.1074/jbc.271.15.8593

PubMed ID: 7882982

Title: Purification of the sequence-specific transcription factor CTCBF, involved in the control of human collagen IV genes: subunits with homology to Ku antigen.

PubMed ID: 7882982

DOI: 10.1002/j.1460-2075.1995.tb07057.x

PubMed ID: 7957065

Title: Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen.

PubMed ID: 7957065

DOI: 10.1002/j.1460-2075.1994.tb06826.x

PubMed ID: 9362500

Title: Double-strand break repair by Ku70 requires heterodimerization with Ku80 and DNA binding functions.

PubMed ID: 9362500

DOI: 10.1093/emboj/16.22.6874

PubMed ID: 9742108

Title: Productive and nonproductive complexes of Ku and DNA-dependent protein kinase at DNA termini.

PubMed ID: 9742108

DOI: 10.1128/mcb.18.10.5908

PubMed ID: 10026262

Title: DNA-dependent protein kinase phosphorylation sites in Ku 70/80 heterodimer.

PubMed ID: 10026262

DOI: 10.1021/bi982584b

PubMed ID: 10377944

Title: Ku, a DNA repair protein with multiple cellular functions?

PubMed ID: 10377944

DOI: 10.1016/s0921-8777(99)00006-3

PubMed ID: 10219089

Title: Isolation of Ku70-binding proteins (KUBs).

PubMed ID: 10219089

DOI: 10.1093/nar/27.10.2165

PubMed ID: 12509254

Title: Defining interactions between DNA-PK and ligase IV/XRCC4.

PubMed ID: 12509254

DOI: 10.1016/s1568-7864(01)00018-0

PubMed ID: 12145306

Title: Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex.

PubMed ID: 12145306

DOI: 10.1074/jbc.m206482200

PubMed ID: 12547193

Title: Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment.

PubMed ID: 12547193

DOI: 10.1016/s0022-2836(02)01328-1

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15075319

Title: Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86.

PubMed ID: 15075319

DOI: 10.1074/jbc.m401356200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20493174

Title: 55K isoform of CDK9 associates with Ku70 and is involved in DNA repair.

PubMed ID: 20493174

DOI: 10.1016/j.bbrc.2010.05.092

PubMed ID: 23972994

Title: ABH2 couples regulation of ribosomal DNA transcription with DNA alkylation repair.

PubMed ID: 23972994

DOI: 10.1016/j.celrep.2013.07.027

PubMed ID: 23689425

Title: Identification and functional characterization of a Ku-binding motif in aprataxin polynucleotide kinase/phosphatase-like factor (APLF).

PubMed ID: 23689425

DOI: 10.1074/jbc.m112.440388

PubMed ID: 27063109

Title: The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins.

PubMed ID: 27063109

DOI: 10.1038/ncomms11242

PubMed ID: 20383123

Title: Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends.

PubMed ID: 20383123

DOI: 10.1038/nature08926

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22442688

Title: Deformed epidermal autoregulatory factor-1 (DEAF1) interacts with the Ku70 subunit of the DNA-dependent protein kinase complex.

PubMed ID: 22442688

DOI: 10.1371/journal.pone.0033404

PubMed ID: 23685356

Title: HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment.

PubMed ID: 23685356

DOI: 10.1038/emboj.2013.105

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24610814

Title: A human short open reading frame (sORF)-encoded polypeptide that stimulates DNA end joining.

PubMed ID: 24610814

DOI: 10.1074/jbc.c113.533968

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 24598253

Title: PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways.

PubMed ID: 24598253

DOI: 10.1093/nar/gku174

PubMed ID: 25852083

Title: DNA-dependent protein kinase (DNA-PK) permits vascular smooth muscle cell proliferation through phosphorylation of the orphan nuclear receptor NOR1.

PubMed ID: 25852083

DOI: 10.1093/cvr/cvv126

PubMed ID: 25941166

Title: XLS (c9orf142) is a new component of mammalian DNA double-stranded break repair.

PubMed ID: 25941166

DOI: 10.1038/cdd.2015.22

PubMed ID: 25670504

Title: Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway.

PubMed ID: 25670504

DOI: 10.1038/ncomms7233

PubMed ID: 26359349

Title: Heat shock factor 1, an inhibitor of non-homologous end joining repair.

PubMed ID: 26359349

DOI: 10.18632/oncotarget.5073

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25574025

Title: DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair.

PubMed ID: 25574025

DOI: 10.1126/science.1261971

PubMed ID: 27601299

Title: Specific roles of XRCC4 paralogs PAXX and XLF during V(D)J recombination.

PubMed ID: 27601299

DOI: 10.1016/j.celrep.2016.08.069

PubMed ID: 27705800

Title: PAXX is an accessory c-NHEJ factor that associates with Ku70 and has overlapping functions with XLF.

PubMed ID: 27705800

DOI: 10.1016/j.celrep.2016.09.026

PubMed ID: 28712728

Title: HEXIM1 and NEAT1 Long non-coding RNA form a multi-subunit complex that regulates DNA-mediated innate immune response.

PubMed ID: 28712728

DOI: 10.1016/j.molcel.2017.06.020

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28959974

Title: Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN.

PubMed ID: 28959974

DOI: 10.1038/nature24023

PubMed ID: 29769340

Title: non-homologous end joining (NHEJ).

PubMed ID: 29769340

DOI: 10.1128/jvi.00672-18

PubMed ID: 29490055

Title: ATF7 mediates TNF-alpha-induced telomere shortening.

PubMed ID: 29490055

DOI: 10.1093/nar/gky155

PubMed ID: 11457852

Title: The three-dimensional structure of the C-terminal DNA-binding domain of human Ku70.

PubMed ID: 11457852

DOI: 10.1074/jbc.m105238200

PubMed ID: 11493912

Title: Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair.

PubMed ID: 11493912

DOI: 10.1038/35088000

PubMed ID: 34352203

Title: Cryo-EM of NHEJ supercomplexes provides insights into DNA repair.

PubMed ID: 34352203

DOI: 10.1016/j.molcel.2021.07.005

PubMed ID: 33854234

Title: Structural basis of long-range to short-range synaptic transition in NHEJ.

PubMed ID: 33854234

DOI: 10.1038/s41586-021-03458-7

Sequence Information:

  • Length: 609
  • Mass: 69843
  • Checksum: BBD3CD434526DFCB
  • Sequence:
    • MSGWESYYKT EGDEEAEEEQ EENLEASGDY KYSGRDSLIF LVDASKAMFE SQSEDELTPF 
DMSIQCIQSV YISKIISSDR DLLAVVFYGT EKDKNSVNFK NIYVLQELDN PGAKRILELD 
QFKGQQGQKR FQDMMGHGSD YSLSEVLWVC ANLFSDVQFK MSHKRIMLFT NEDNPHGNDS 
AKASRARTKA GDLRDTGIFL DLMHLKKPGG FDISLFYRDI ISIAEDEDLR VHFEESSKLE 
DLLRKVRAKE TRKRALSRLK LKLNKDIVIS VGIYNLVQKA LKPPPIKLYR ETNEPVKTKT 
RTFNTSTGGL LLPSDTKRSQ IYGSRQIILE KEETEELKRF DDPGLMLMGF KPLVLLKKHH 
YLRPSLFVYP EESLVIGSST LFSALLIKCL EKEVAALCRY TPRRNIPPYF VALVPQEEEL 
DDQKIQVTPP GFQLVFLPFA DDKRKMPFTE KIMATPEQVG KMKAIVEKLR FTYRSDSFEN 
PVLQQHFRNL EALALDLMEP EQAVDLTLPK VEAMNKRLGS LVDEFKELVY PPDYNPEGKV 
TKRKHDNEGS GSKRPKVEYS EEELKTHISK GTLGKFTVPM LKEACRAYGL KSGLKKQELL 
EALTKHFQD

Genular Protein ID: 4071021555

Symbol: B4E356_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E356

Database IDs:

ARBA 12 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 9 Gene3D 5 GenomeRNAi 1 InterPro 10 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PIRSF 1 PROSITE 2 PeptideAtlas 1 Pfam 4 RefSeq 1 SAM 1 SMART 2 SUPFAM 3

Sequence Information:

  • Length: 476
  • Mass: 54452
  • Checksum: F5EA3430A82A1EBD
  • Sequence:
    • MMGHGSDYSL SEVLWVCANL FSDVQFKMSH KRIMLFTNED NPHGNDSAKA SRARTKAGDL 
RDTGIFLDLM HLKKPGGFDI SLFYRDIISI AEDEDLRVHF EESSKLEDLL RKVRAKETRK 
RALSRLKLKL NKDIVISVGI YNLVQKALKP PPIKLYRETN EPVKTKTRTF NTSTGGLLLP 
SDTKGSQIYG SRQIILEKEE TEELKRFDDP GLMLMGFKPL VLLKKHHYLR PSLFVYPEES 
LVIGSSTLFS ALLIKCLEKE VAALCRYTPR RNIPPYFVAL VPQEEELDDQ KIQVTPPGFQ 
LVFLPFADDK RKMPFTEKIM ATPEQVGKMK AIVEKLRFTY RSDSFENPVL QQHFRNLEAL 
ALDLMEPEQA VDLTLPKVEA MNKRLGSLVD EFKELVYPPD YNPEGKVTKR KHDNEGSGSK 
RPKVEYSEEE LKTHISKGTL GKFTVPMLKE ACRAYGLKSG LKKQELLEAL TKHFQD

Genular Protein ID: 4067411206

Symbol: B1AHC9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B1AHC9 F5H1I8

Database IDs:

ARBA 12 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 3 GO 10 Gene3D 5 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 10 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PIRSF 1 PROSITE 2 Pfam 4 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMART 2 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 559
  • Mass: 64284
  • Checksum: 92F7F26A448CA3D3
  • Sequence:
    • MKKQRKNKKR TLKQVCIQSV YISKIISSDR DLLAVVFYGT EKDKNSVNFK NIYVLQELDN 
PGAKRILELD QFKGQQGQKR FQDMMGHGSD YSLSEVLWVC ANLFSDVQFK MSHKRIMLFT 
NEDNPHGNDS AKASRARTKA GDLRDTGIFL DLMHLKKPGG FDISLFYRDI ISIAEDEDLR 
VHFEESSKLE DLLRKVRAKE TRKRALSRLK LKLNKDIVIS VGIYNLVQKA LKPPPIKLYR 
ETNEPVKTKT RTFNTSTGGL LLPSDTKRSQ IYGSRQIILE KEETEELKRF DDPGLMLMGF 
KPLVLLKKHH YLRPSLFVYP EESLVIGSST LFSALLIKCL EKEVAALCRY TPRRNIPPYF 
VALVPQEEEL DDQKIQVTPP GFQLVFLPFA DDKRKMPFTE KIMATPEQVG KMKAIVEKLR 
FTYRSDSFEN PVLQQHFRNL EALALDLMEP EQAVDLTLPK VEAMNKRLGS LVDEFKELVY 
PPDYNPEGKV TKRKHDNEGS GSKRPKVEYS EEELKTHISK GTLGKFTVPM LKEACRAYGL 
KSGLKKQELL EALTKHFQD

Genular Protein ID: 3890355496

Symbol: B4DE32_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DE32

Database IDs:

ARBA 12 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EMBL 2 GO 9 Gene3D 5 GenomeRNAi 1 InterPro 10 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PIRSF 1 PROSITE 2 PeptideAtlas 1 Pfam 4 RefSeq 1 SAM 1 SMART 2 SUPFAM 3

Sequence Information:

  • Length: 559
  • Mass: 64241
  • Checksum: 92F110650F2CA3D3
  • Sequence:
    • MKKQRKNKKR TLKQVCIQSV YISKIISSDL DLLAVVFYGT EKDKNSVNFK NIYVLQELDN 
PGAKRILELD QFKGQQGQKR FQDMMGHGSD YSLSEVLWVC ANLFSDVQFK MSHKRIMLFT 
NEDNPHGNDS AKASRARTKA GDLRDTGIFL DLMHLKKPGG FDISLFYRDI ISIAEDEDLR 
VHFEESSKLE DLLRKVRAKE TRKRALSRLK LKLNKDIVIS VGIYNLVQKA LKPPPIKLYR 
ETNEPVKTKT RTFNTSTGGL LLPSDTKRSQ IYGSRQIILE KEETEELKRF DDPGLMLMGF 
KPLVLLKKHH YLRPSLFVYP EESLVIGSST LFSALLIKCL EKEVAALCRY TPRRNIPPYF 
VALVPQEEEL DDQKIQVTPP GFQLVFLPFA DDKRKMPFTE KIMATPEQVG KMKAIVEKLR 
FTYRSDSFEN PVLQQHFRNL EALALDLMEP EQAVDLTLPK VEAMNKRLGS LVDEFKELVY 
PPDYNPEGKV TKRKHDNEGS GSKRPKVEYS EEELKTHISK GTLGKFTVPM LKEACRAYGL 
KSGLKKQELL EALTKHFQD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.