Details for: TNFAIP3

Gene ID: 7128

Symbol: TNFAIP3

Ensembl ID: ENSG00000118503

Description: TNF alpha induced protein 3

Associated with

  • Ddx58/ifih1-mediated induction of interferon-alpha/beta
    (R-HSA-168928)
  • Death receptor signaling
    (R-HSA-73887)
  • Deubiquitination
    (R-HSA-5688426)
  • Immune system
    (R-HSA-168256)
  • Innate immune system
    (R-HSA-168249)
  • Metabolism of proteins
    (R-HSA-392499)
  • Negative regulators of ddx58/ifih1 signaling
    (R-HSA-936440)
  • Nod1/2 signaling pathway
    (R-HSA-168638)
  • Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
    (R-HSA-168643)
  • Ovarian tumor domain proteases
    (R-HSA-5689896)
  • Post-translational protein modification
    (R-HSA-597592)
  • Regulation of tnfr1 signaling
    (R-HSA-5357905)
  • Signal transduction
    (R-HSA-162582)
  • Tnfr1-induced nf-kappa-b signaling pathway
    (R-HSA-5357956)
  • Tnfr1-induced proapoptotic signaling
    (R-HSA-5357786)
  • Tnf signaling
    (R-HSA-75893)
  • Apoptotic process
    (GO:0006915)
  • B-1 b cell homeostasis
    (GO:0001922)
  • Cell migration
    (GO:0016477)
  • Cellular response to hydrogen peroxide
    (GO:0070301)
  • Cellular response to lipopolysaccharide
    (GO:0071222)
  • Cysteine-type deubiquitinase activity
    (GO:0004843)
  • Cytoplasm
    (GO:0005737)
  • Cytoskeleton organization
    (GO:0007010)
  • Cytosol
    (GO:0005829)
  • Dna binding
    (GO:0003677)
  • Establishment of protein localization to vacuole
    (GO:0072666)
  • Extracellular exosome
    (GO:0070062)
  • Identical protein binding
    (GO:0042802)
  • Inflammatory response
    (GO:0006954)
  • K63-linked deubiquitinase activity
    (GO:0061578)
  • K63-linked polyubiquitin modification-dependent protein binding
    (GO:0070530)
  • Kinase binding
    (GO:0019900)
  • Lysosome
    (GO:0005764)
  • Negative regulation of b cell activation
    (GO:0050869)
  • Negative regulation of bone resorption
    (GO:0045779)
  • Negative regulation of canonical nf-kappab signal transduction
    (GO:0043124)
  • Negative regulation of cd40 signaling pathway
    (GO:2000349)
  • Negative regulation of chronic inflammatory response
    (GO:0002677)
  • Negative regulation of endothelial cell apoptotic process
    (GO:2000352)
  • Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
    (GO:1902042)
  • Negative regulation of inflammatory response
    (GO:0050728)
  • Negative regulation of innate immune response
    (GO:0045824)
  • Negative regulation of interleukin-1 beta production
    (GO:0032691)
  • Negative regulation of interleukin-2 production
    (GO:0032703)
  • Negative regulation of interleukin-6 production
    (GO:0032715)
  • Negative regulation of nf-kappab transcription factor activity
    (GO:0032088)
  • Negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
    (GO:0070429)
  • Negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
    (GO:0070433)
  • Negative regulation of osteoclast proliferation
    (GO:0090291)
  • Negative regulation of protein ubiquitination
    (GO:0031397)
  • Negative regulation of smooth muscle cell proliferation
    (GO:0048662)
  • Negative regulation of toll-like receptor 2 signaling pathway
    (GO:0034136)
  • Negative regulation of toll-like receptor 3 signaling pathway
    (GO:0034140)
  • Negative regulation of toll-like receptor 4 signaling pathway
    (GO:0034144)
  • Negative regulation of toll-like receptor 5 signaling pathway
    (GO:0034148)
  • Negative regulation of tumor necrosis factor production
    (GO:0032720)
  • Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
    (GO:0035872)
  • Nucleus
    (GO:0005634)
  • Positive regulation of hepatocyte proliferation
    (GO:2000347)
  • Positive regulation of protein catabolic process
    (GO:0045732)
  • Positive regulation of wnt signaling pathway
    (GO:0030177)
  • Protease binding
    (GO:0002020)
  • Protein binding
    (GO:0005515)
  • Protein deubiquitination
    (GO:0016579)
  • Protein deubiquitination involved in ubiquitin-dependent protein catabolic process
    (GO:0071947)
  • Protein k11-linked deubiquitination
    (GO:0035871)
  • Protein k29-linked deubiquitination
    (GO:0035523)
  • Protein k33-linked deubiquitination
    (GO:1990168)
  • Protein k48-linked deubiquitination
    (GO:0071108)
  • Protein k48-linked ubiquitination
    (GO:0070936)
  • Protein k63-linked deubiquitination
    (GO:0070536)
  • Protein self-association
    (GO:0043621)
  • Proteolysis
    (GO:0006508)
  • Regulation of defense response to virus by host
    (GO:0050691)
  • Regulation of germinal center formation
    (GO:0002634)
  • Regulation of tumor necrosis factor-mediated signaling pathway
    (GO:0010803)
  • Regulation of vascular wound healing
    (GO:0061043)
  • Response to molecule of bacterial origin
    (GO:0002237)
  • Response to muramyl dipeptide
    (GO:0032495)
  • Tolerance induction to lipopolysaccharide
    (GO:0072573)
  • Ubiquitin-protein transferase activity
    (GO:0004842)
  • Ubiquitin binding
    (GO:0043130)
  • Zinc ion binding
    (GO:0008270)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.65
    Marker Score: 15667
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 3.43
    Marker Score: 8368.5
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.38
    Marker Score: 9489
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 3.22
    Marker Score: 4441
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 3.2
    Marker Score: 1376
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 3.2
    Marker Score: 7861
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.13
    Marker Score: 9868
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 3.02
    Marker Score: 2193
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.95
    Marker Score: 29253
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 2.95
    Marker Score: 1514.5
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.9
    Marker Score: 1449
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.88
    Marker Score: 97856
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 2.86
    Marker Score: 2096
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.8
    Marker Score: 2459
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.73
    Marker Score: 846
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.63
    Marker Score: 2462
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.6
    Marker Score: 137281
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.57
    Marker Score: 7097
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.54
    Marker Score: 2137
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 2.48
    Marker Score: 1527
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 2.48
    Marker Score: 1599
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.47
    Marker Score: 137897
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.42
    Marker Score: 3559
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.41
    Marker Score: 1411
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 2.39
    Marker Score: 1808
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.37
    Marker Score: 803
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 2.32
    Marker Score: 2500
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.27
    Marker Score: 2018.5
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 2.25
    Marker Score: 1846
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.23
    Marker Score: 999
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.11
    Marker Score: 1801
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.03
    Marker Score: 2319
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.02
    Marker Score: 9935
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.96
    Marker Score: 596
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.95
    Marker Score: 1328
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 1.95
    Marker Score: 4380
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1.93
    Marker Score: 693
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1.9
    Marker Score: 418
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.87
    Marker Score: 1361
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.86
    Marker Score: 803
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.85
    Marker Score: 3040
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.85
    Marker Score: 1064
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.83
    Marker Score: 1438
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.82
    Marker Score: 863
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.81
    Marker Score: 7506
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 1.8
    Marker Score: 407
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.75
    Marker Score: 1463
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.72
    Marker Score: 739
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.71
    Marker Score: 2522
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.71
    Marker Score: 1892
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.7
    Marker Score: 2920
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.68
    Marker Score: 4894.5
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.66
    Marker Score: 690
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.65
    Marker Score: 3219
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.65
    Marker Score: 2939
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.6
    Marker Score: 9736
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.59
    Marker Score: 1768.5
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.58
    Marker Score: 4088
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.53
    Marker Score: 2171
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.53
    Marker Score: 1108
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.52
    Marker Score: 2646
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.52
    Marker Score: 3659
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.48
    Marker Score: 1253
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.47
    Marker Score: 2139
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.46
    Marker Score: 980
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.45
    Marker Score: 16882
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166218
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.43
    Marker Score: 984
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 1.42
    Marker Score: 361
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.42
    Marker Score: 5259
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.41
    Marker Score: 3450
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.41
    Marker Score: 15831.5
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.4
    Marker Score: 1688
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 1.39
    Marker Score: 584
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.38
    Marker Score: 1173
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 1.35
    Marker Score: 2195
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.34
    Marker Score: 841
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.33
    Marker Score: 1484
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 1.33
    Marker Score: 1722
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.33
    Marker Score: 683
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.32
    Marker Score: 669
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.31
    Marker Score: 5650
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.31
    Marker Score: 2212
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.31
    Marker Score: 325
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.29
    Marker Score: 325
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.27
    Marker Score: 2488
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.27
    Marker Score: 1379
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.27
    Marker Score: 462
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.25
    Marker Score: 245
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.24
    Marker Score: 712
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.24
    Marker Score: 1452
  • Cell Name: monocyte (CL0000576)
    Fold Change: 1.24
    Marker Score: 1609
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.23
    Marker Score: 249
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1.23
    Marker Score: 426
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.23
    Marker Score: 1024
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.23
    Marker Score: 1249
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.22
    Marker Score: 1344
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.21
    Marker Score: 495
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.21
    Marker Score: 834
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.21
    Marker Score: 1191

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Other Information

**Key Characteristics:** TNFAIP3 is a cytoplasmic protein that exhibits deubiquitinating activity, specifically targeting and removing ubiquitin from specific protein substrates. This function enables TNFAIP3 to regulate various signaling pathways, including those involved in inflammation, apoptosis, and immune cell homeostasis. TNFAIP3 is highly expressed in immune cells, such as T-helper 22 cells, central memory CD8-positive T cells, and natural T-regulatory cells. **Pathways and Functions:** TNFAIP3's deubiquitinating activity affects multiple signaling pathways, including: 1. **Inflammatory response:** TNFAIP3 negatively regulates the production of pro-inflammatory cytokines, such as TNF-alpha, IL-1beta, and IL-6, thereby reducing inflammation. 2. **Apoptosis:** TNFAIP3 inhibits apoptosis by removing ubiquitin from pro-apoptotic proteins, such as caspase-1 and caspase-8. 3. **Immune cell homeostasis:** TNFAIP3 regulates the activation and proliferation of immune cells, including T cells and B cells. 4. **Cytoskeleton organization:** TNFAIP3 affects the organization of the cytoskeleton, which is essential for cell migration and adhesion. 5. **Cellular response to oxidative stress:** TNFAIP3 mitigates the effects of oxidative stress by removing ubiquitin from proteins involved in oxidative damage. **Clinical Significance:** Dysregulation of TNFAIP3 has been implicated in various immune-related disorders, including: 1. **Rheumatoid arthritis:** TNFAIP3 mutations have been associated with rheumatoid arthritis, a chronic autoimmune disease characterized by inflammation and joint damage. 2. **Systemic lupus erythematosus:** TNFAIP3 is also implicated in systemic lupus erythematosus, an autoimmune disease characterized by inflammation and immune complex deposition. 3. **Inflammatory bowel disease:** TNFAIP3 expression is reduced in inflammatory bowel disease, suggesting its role in regulating inflammation in the gut. 4. **Cancer:** TNFAIP3's anti-inflammatory and anti-apoptotic functions may also contribute to cancer development and progression. In conclusion, TNFAIP3 plays a crucial role in regulating immune responses and maintaining immune homeostasis. Its dysregulation has been implicated in various immune-related disorders, highlighting the importance of this gene in understanding immune-mediated diseases.

Genular Protein ID: 2330592556

Symbol: TNAP3_HUMAN

Name: Tumor necrosis factor alpha-induced protein 3

UniProtKB Accession Codes:

P21580 B2R767 E1P588 Q2HIX9 Q5VXQ7 Q9NSR6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 28 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 9 EPD 1 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 64 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 26 PDBsum 17 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 6 RefSeq 5 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2118515

Title: The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein.

PubMed ID: 2118515

DOI: 10.1016/s0021-9258(18)77165-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 8692885

Title: The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation.

PubMed ID: 8692885

DOI: 10.1073/pnas.93.13.6721

PubMed ID: 9299557

Title: A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins.

PubMed ID: 9299557

DOI: 10.1006/bbrc.1997.7343

PubMed ID: 9882303

Title: Epstein-Barr virus-encoded latent membrane protein 1 activates the JNK pathway through its extreme C-terminus via a mechanism involving TRADD and TRAF2.

PubMed ID: 9882303

DOI: 10.1128/jvi.73.2.1023-1035.1999

PubMed ID: 10435631

Title: The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases.

PubMed ID: 10435631

DOI: 10.1038/sj.onc.1202787

PubMed ID: 11463333

Title: Isolation and characterization of two novel A20-like proteins.

PubMed ID: 11463333

DOI: 10.1042/0264-6021:3570617

PubMed ID: 14748687

Title: Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity.

PubMed ID: 14748687

DOI: 10.1042/bj20031377

PubMed ID: 15258597

Title: De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling.

PubMed ID: 15258597

DOI: 10.1038/nature02794

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16684768

Title: ABIN-1 binds to NEMO/IKKgamma and co-operates with A20 in inhibiting NF-kappaB.

PubMed ID: 16684768

DOI: 10.1074/jbc.m601502200

PubMed ID: 18223652

Title: T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20.

PubMed ID: 18223652

DOI: 10.1038/ni1561

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18952128

Title: The zinc finger protein A20 targets TRAF2 to the lysosomes for degradation.

PubMed ID: 18952128

DOI: 10.1016/j.bbamcr.2008.09.013

PubMed ID: 19131965

Title: The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling.

PubMed ID: 19131965

DOI: 10.1038/emboj.2008.285

PubMed ID: 19494296

Title: A20 negatively regulates T cell receptor signaling to NF-kappaB by cleaving Malt1 ubiquitin chains.

PubMed ID: 19494296

DOI: 10.4049/jimmunol.0803313

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20804738

Title: Cleavage by MALT1 induces cytosolic release of A20.

PubMed ID: 20804738

DOI: 10.1016/j.bbrc.2010.08.091

PubMed ID: 22099304

Title: Direct, noncatalytic mechanism of IKK inhibition by A20.

PubMed ID: 22099304

DOI: 10.1016/j.molcel.2011.09.015

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23827681

Title: OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.

PubMed ID: 23827681

DOI: 10.1016/j.cell.2013.05.046

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26642243

Title: Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease.

PubMed ID: 26642243

DOI: 10.1038/ng.3459

PubMed ID: 17961127

Title: Structure of the A20 OTU domain and mechanistic insights into deubiquitination.

PubMed ID: 17961127

DOI: 10.1042/bj20071399

PubMed ID: 18164316

Title: Molecular basis for the unique deubiquitinating activity of the NF-kappaB inhibitor A20.

PubMed ID: 18164316

DOI: 10.1016/j.jmb.2007.11.092

PubMed ID: 21095585

Title: Ubiquitin binding to A20 ZnF4 is required for modulation of NF-kappaB signaling.

PubMed ID: 21095585

DOI: 10.1016/j.molcel.2010.10.009

PubMed ID: 27732584

Title: Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.

PubMed ID: 27732584

DOI: 10.1038/nature19836

PubMed ID: 27175295

Title: Novel heterozygous C243Y A20/TNFAIP3 gene mutation is responsible for chronic inflammation in autosomal-dominant Behcet's disease.

PubMed ID: 27175295

DOI: 10.1136/rmdopen-2015-000223

Sequence Information:

  • Length: 790
  • Mass: 89614
  • Checksum: 320AEA97F58D4491
  • Sequence:
    • MAEQVLPQAL YLSNMRKAVK IRERTPEDIF KPTNGIIHHF KTMHRYTLEM FRTCQFCPQF 
REIIHKALID RNIQATLESQ KKLNWCREVR KLVALKTNGD GNCLMHATSQ YMWGVQDTDL 
VLRKALFSTL KETDTRNFKF RWQLESLKSQ EFVETGLCYD TRNWNDEWDN LIKMASTDTP 
MARSGLQYNS LEEIHIFVLC NILRRPIIVI SDKMLRSLES GSNFAPLKVG GIYLPLHWPA 
QECYRYPIVL GYDSHHFVPL VTLKDSGPEI RAVPLVNRDR GRFEDLKVHF LTDPENEMKE 
KLLKEYLMVI EIPVQGWDHG TTHLINAAKL DEANLPKEIN LVDDYFELVQ HEYKKWQENS 
EQGRREGHAQ NPMEPSVPQL SLMDVKCETP NCPFFMSVNT QPLCHECSER RQKNQNKLPK 
LNSKPGPEGL PGMALGASRG EAYEPLAWNP EESTGGPHSA PPTAPSPFLF SETTAMKCRS 
PGCPFTLNVQ HNGFCERCHN ARQLHASHAP DHTRHLDPGK CQACLQDVTR TFNGICSTCF 
KRTTAEASSS LSTSLPPSCH QRSKSDPSRL VRSPSPHSCH RAGNDAPAGC LSQAARTPGD 
RTGTSKCRKA GCVYFGTPEN KGFCTLCFIE YRENKHFAAA SGKVSPTASR FQNTIPCLGR 
ECGTLGSTMF EGYCQKCFIE AQNQRFHEAK RTEEQLRSSQ RRDVPRTTQS TSRPKCARAS 
CKNILACRSE ELCMECQHPN QRMGPGAHRG EPAPEDPPKQ RCRAPACDHF GNAKCNGYCN 
ECFQFKQMYG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.