Details for: TIMP1

Gene ID: 7076

Symbol: TIMP1

Ensembl ID: ENSG00000102265

Description: TIMP metallopeptidase inhibitor 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 4.2
    Marker Score: 3579
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.13
    Marker Score: 140611
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 3.91
    Marker Score: 1254
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.6
    Marker Score: 4943
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.55
    Marker Score: 198388
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 3.54
    Marker Score: 2000
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 3.53
    Marker Score: 9239
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.51
    Marker Score: 22820
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.44
    Marker Score: 1432
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.43
    Marker Score: 8709
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.38
    Marker Score: 2425
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 3.36
    Marker Score: 8114
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.28
    Marker Score: 3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.28
    Marker Score: 8004
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.27
    Marker Score: 6362
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.23
    Marker Score: 3692
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.18
    Marker Score: 4895
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.11
    Marker Score: 41052
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.99
    Marker Score: 26207
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.98
    Marker Score: 1698
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.97
    Marker Score: 1025
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.97
    Marker Score: 5584
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.94
    Marker Score: 2936
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.91
    Marker Score: 12569
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.89
    Marker Score: 4190
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.87
    Marker Score: 2443.5
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.86
    Marker Score: 15022
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.85
    Marker Score: 3517.5
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.84
    Marker Score: 31953
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.83
    Marker Score: 1650
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.81
    Marker Score: 4609
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.79
    Marker Score: 1202
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.76
    Marker Score: 5514
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.75
    Marker Score: 95395
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.74
    Marker Score: 1948
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.74
    Marker Score: 3979
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.72
    Marker Score: 6775.5
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.71
    Marker Score: 2336
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.71
    Marker Score: 31505
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.7
    Marker Score: 855
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.64
    Marker Score: 15645
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.62
    Marker Score: 3419
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.57
    Marker Score: 641
  • Cell Name: basophil (CL0000767)
    Fold Change: 2.57
    Marker Score: 1222
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.56
    Marker Score: 1148
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 2.56
    Marker Score: 2473
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.55
    Marker Score: 641
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 2.54
    Marker Score: 10539
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 2.52
    Marker Score: 713
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.48
    Marker Score: 1038
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 2.47
    Marker Score: 1560
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.47
    Marker Score: 6392
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 2.45
    Marker Score: 537
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.45
    Marker Score: 1610
  • Cell Name: PP cell (CL0000696)
    Fold Change: 2.43
    Marker Score: 547
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.43
    Marker Score: 2166
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.42
    Marker Score: 1010
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.4
    Marker Score: 2431
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.39
    Marker Score: 850
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.38
    Marker Score: 1872
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 2.37
    Marker Score: 651
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 2.37
    Marker Score: 534
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.37
    Marker Score: 615
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.36
    Marker Score: 4310
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.35
    Marker Score: 9063
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.34
    Marker Score: 23595
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.34
    Marker Score: 6378
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.33
    Marker Score: 1152
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.33
    Marker Score: 851
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.33
    Marker Score: 904
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.33
    Marker Score: 4120
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.31
    Marker Score: 2456
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.27
    Marker Score: 643
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 2.24
    Marker Score: 571
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.22
    Marker Score: 512
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.22
    Marker Score: 1994
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.22
    Marker Score: 1142
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.21
    Marker Score: 2379
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.19
    Marker Score: 13284
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.19
    Marker Score: 631
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.18
    Marker Score: 13950
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 2.17
    Marker Score: 875
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.16
    Marker Score: 2173
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.12
    Marker Score: 9081
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.08
    Marker Score: 15473
  • Cell Name: pericyte (CL0000669)
    Fold Change: 2.06
    Marker Score: 1202
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 2.05
    Marker Score: 824
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.03
    Marker Score: 2997
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.03
    Marker Score: 52040
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.03
    Marker Score: 2380
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 2.02
    Marker Score: 491
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.02
    Marker Score: 4221
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.02
    Marker Score: 4753
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.02
    Marker Score: 3414
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.99
    Marker Score: 2321
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.98
    Marker Score: 1868
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.96
    Marker Score: 1871
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.96
    Marker Score: 483
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.95
    Marker Score: 453
  • Cell Name: platelet (CL0000233)
    Fold Change: 1.92
    Marker Score: 870

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key Characteristics:** TIMP1 is a 41-kDa protein with a conserved metalloprotease inhibitory domain. It is widely expressed in various tissues, including connective tissue, epithelial, and endothelial cells. TIMP1 has been shown to interact with MMPs, inhibiting their activity and preventing excessive matrix degradation. Additionally, TIMP1 has been implicated in regulating cell proliferation, differentiation, and survival through its interactions with growth factors and signaling pathways. **Pathways and Functions:** TIMP1 is involved in a wide range of cellular processes, including: 1. **Extracellular matrix regulation**: TIMP1 inhibits MMP activity, preventing excessive matrix degradation and maintaining tissue structure. 2. **Cell growth and differentiation**: TIMP1 regulates cell proliferation and differentiation by interacting with growth factors and signaling pathways. 3. **Apoptosis regulation**: TIMP1 inhibits apoptotic processes by interacting with pro-apoptotic proteins. 4. **Cytokine signaling**: TIMP1 modulates cytokine activity, influencing immune responses and inflammation. 5. **Wound healing**: TIMP1 plays a crucial role in wound healing by regulating matrix remodeling and tissue repair. **Clinical Significance:** TIMP1 has been implicated in various diseases, including: 1. **Cancer**: Elevated TIMP1 expression has been associated with tumor progression and metastasis. 2. **Arthritis**: TIMP1 has been linked to rheumatoid arthritis, with elevated expression contributing to joint destruction. 3. **Cardiovascular disease**: TIMP1 has been implicated in atherosclerosis and cardiovascular disease, with altered expression contributing to disease progression. 4. **Neurological disorders**: TIMP1 has been linked to neurodegenerative diseases, including Alzheimer's and Parkinson's disease. In conclusion, TIMP1 is a multifaceted protein that plays a critical role in regulating various cellular processes, including extracellular matrix regulation, cell growth and differentiation, apoptosis, cytokine signaling, and wound healing. Its dysregulation has been implicated in various diseases, highlighting the importance of TIMP1 in human health and disease. Further research is needed to fully elucidate the role of TIMP1 in these processes and to explore its therapeutic potential.

Genular Protein ID: 1954692007

Symbol: TIMP1_HUMAN

Name: Metalloproteinase inhibitor 1

UniProtKB Accession Codes:

P01033 Q14252 Q9UCU1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 1 CPTC 1 CTD 1 ChEBI 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 27 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 10 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 6 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3903517

Title: Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity.

PubMed ID: 3903517

DOI: 10.1038/318066a0

PubMed ID: 3839290

Title: Molecular characterization and expression of the gene encoding human erythroid-potentiating activity.

PubMed ID: 3839290

DOI: 10.1038/315768a0

PubMed ID: 3010309

Title: Primary structure and cDNA cloning of human fibroblast collagenase inhibitor.

PubMed ID: 3010309

DOI: 10.1073/pnas.83.8.2407

PubMed ID: 2171551

Title: Characterization of three abundant mRNAs from human ovarian granulosa cells.

PubMed ID: 2171551

DOI: 10.1089/dna.1990.9.479

PubMed ID: 7507419

Title: Characterization of a human corneal metalloproteinase inhibitor (TIMP-1).

PubMed ID: 7507419

DOI: 10.3109/02713689309020394

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9286280

Title: Genomic organization of the human TIMP-1 gene. Investigation of a causative role in the pathogenesis of X-linked retinitis pigmentosa 2.

PubMed ID: 9286280

PubMed ID: 1730286

Title: Isolation and characterization of tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) from human rheumatoid synovial fluid.

PubMed ID: 1730286

DOI: 10.1016/0014-5793(92)80393-u

PubMed ID: 1653055

Title: The cytokine-protease connection: identification of a 96-kD THP-1 gelatinase and regulation by interleukin-1 and cytokine inducers.

PubMed ID: 1653055

DOI: 10.1016/1043-4666(91)90021-5

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 2163605

Title: Disulphide bond assignment in human tissue inhibitor of metalloproteinases (TIMP).

PubMed ID: 2163605

DOI: 10.1042/bj2680267

PubMed ID: 1420137

Title: Site-directed mutations that alter the inhibitory activity of the tissue inhibitor of metalloproteinases-1: importance of the N-terminal region between cysteine 3 and cysteine 13.

PubMed ID: 1420137

DOI: 10.1021/bi00157a002

PubMed ID: 8541540

Title: Metalloproteinase inhibition and erythroid potentiation are independent activities of tissue inhibitor of metalloproteinases-1.

PubMed ID: 8541540

PubMed ID: 8576151

Title: Biochemical characterization of human collagenase-3.

PubMed ID: 8576151

DOI: 10.1074/jbc.271.3.1544

PubMed ID: 9065415

Title: The role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interaction.

PubMed ID: 9065415

DOI: 10.1074/jbc.272.12.7608

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16917503

Title: Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein.

PubMed ID: 16917503

DOI: 10.1038/sj.emboj.7601281

PubMed ID: 16740002

Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

PubMed ID: 16740002

DOI: 10.1021/pr050492k

PubMed ID: 16263699

Title: Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.

PubMed ID: 16263699

DOI: 10.1074/mcp.m500324-mcp200

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 23522389

Title: Timp1 interacts with beta-1 integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation.

PubMed ID: 23522389

DOI: 10.1186/1476-4598-12-22

PubMed ID: 24635319

Title: TIMP-1 modulates chemotaxis of human neural stem cells through CD63 and integrin signalling.

PubMed ID: 24635319

DOI: 10.1042/bj20131119

PubMed ID: 23982756

Title: Cytokine functions of TIMP-1.

PubMed ID: 23982756

DOI: 10.1007/s00018-013-1457-3

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 9288970

Title: Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1.

PubMed ID: 9288970

DOI: 10.1038/37995

PubMed ID: 10623524

Title: NMR structure of tissue inhibitor of metalloproteinases-1 implicates localized induced fit in recognition of matrix metalloproteinases.

PubMed ID: 10623524

DOI: 10.1006/jmbi.1999.3362

PubMed ID: 12834347

Title: Global orientation of bound MMP-3 and N-TIMP-1 in solution via residual dipolar couplings.

PubMed ID: 12834347

DOI: 10.1021/bi034545s

PubMed ID: 17050530

Title: Crystal structure of the catalytic domain of matrix metalloproteinase-1 in complex with the inhibitory domain of tissue inhibitor of metalloproteinase-1.

PubMed ID: 17050530

DOI: 10.1074/jbc.m607625200

PubMed ID: 20545310

Title: The intrinsic protein flexibility of endogenous protease inhibitor TIMP-1 controls its binding interface and affects its function.

PubMed ID: 20545310

DOI: 10.1021/bi902141x

PubMed ID: 22427646

Title: Matrix metalloproteinase-10 (MMP10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure.

PubMed ID: 22427646

DOI: 10.1074/jbc.m112.341156

Sequence Information:

  • Length: 207
  • Mass: 23171
  • Checksum: 5AE4F90FFAB2ECDC
  • Sequence:
    • MAPFEPLASG ILLLLWLIAP SRACTCVPPH PQTAFCNSDL VIRAKFVGTP EVNQTTLYQR 
YEIKMTKMYK GFQALGDAAD IRFVYTPAME SVCGYFHRSH NRSEEFLIAG KLQDGLLHIT 
TCSFVAPWNS LSLAQRRGFT KTYTVGCEEC TVFPCLSIPC KLQSGTHCLW TDQLLQGSEK 
GFQSRHLACL PREPGLCTWQ SLRSQIA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.