Details for: TIMP1

Gene ID: 7076

Symbol: TIMP1

Ensembl ID: ENSG00000102265

Description: TIMP metallopeptidase inhibitor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 565.6233
    Cell Significance Index: -87.9800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 325.2598
    Cell Significance Index: -82.5000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 226.2666
    Cell Significance Index: -93.2100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 190.7351
    Cell Significance Index: -77.4900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 188.7433
    Cell Significance Index: -89.1100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 168.1619
    Cell Significance Index: -86.5000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 82.8443
    Cell Significance Index: -79.1000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 71.9247
    Cell Significance Index: -88.6800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 24.8539
    Cell Significance Index: -66.5800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 23.8258
    Cell Significance Index: -73.1800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 22.6885
    Cell Significance Index: -89.5300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.8902
    Cell Significance Index: -30.4000
  • Cell Name: theca cell (CL0000503)
    Fold Change: 12.8238
    Cell Significance Index: 75.3400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 11.4905
    Cell Significance Index: 147.1600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 10.2331
    Cell Significance Index: 293.3400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 6.4094
    Cell Significance Index: 148.0800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 6.2859
    Cell Significance Index: 116.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 5.3889
    Cell Significance Index: 740.0500
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 5.2643
    Cell Significance Index: 21.9100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 5.0245
    Cell Significance Index: 261.7200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 3.6592
    Cell Significance Index: 41.5700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.9915
    Cell Significance Index: 21.4900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.9589
    Cell Significance Index: 57.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.9489
    Cell Significance Index: 378.0300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.7911
    Cell Significance Index: 81.9700
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 2.7896
    Cell Significance Index: 12.8800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.7349
    Cell Significance Index: 1493.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.5811
    Cell Significance Index: 192.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.4166
    Cell Significance Index: 113.5800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.2302
    Cell Significance Index: 39.4100
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 2.1716
    Cell Significance Index: 7.5600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.7551
    Cell Significance Index: 46.1500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5452
    Cell Significance Index: 42.0600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.3267
    Cell Significance Index: 27.7700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.1318
    Cell Significance Index: 17.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1190
    Cell Significance Index: 137.6000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.9991
    Cell Significance Index: 34.7200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8967
    Cell Significance Index: 115.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8208
    Cell Significance Index: 81.2000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.7614
    Cell Significance Index: 4.6000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7378
    Cell Significance Index: 140.4100
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.6653
    Cell Significance Index: 11.4300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5591
    Cell Significance Index: 100.7900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3262
    Cell Significance Index: 144.2100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.3216
    Cell Significance Index: 36.7100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1701
    Cell Significance Index: 7.9300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1078
    Cell Significance Index: 81.6200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0851
    Cell Significance Index: 5.4900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0766
    Cell Significance Index: 5.3000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0150
    Cell Significance Index: 0.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0258
    Cell Significance Index: -19.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0309
    Cell Significance Index: -58.2700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0596
    Cell Significance Index: -109.9300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0701
    Cell Significance Index: -107.8400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0763
    Cell Significance Index: -47.6300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0812
    Cell Significance Index: -110.4300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1010
    Cell Significance Index: -16.4300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1037
    Cell Significance Index: -1.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.1054
    Cell Significance Index: -77.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1104
    Cell Significance Index: -62.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1191
    Cell Significance Index: -75.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1226
    Cell Significance Index: -12.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1330
    Cell Significance Index: -28.0200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1406
    Cell Significance Index: -27.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1551
    Cell Significance Index: -26.4900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1732
    Cell Significance Index: -78.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.2318
    Cell Significance Index: -83.1600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2438
    Cell Significance Index: -3.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2549
    Cell Significance Index: -15.3000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2662
    Cell Significance Index: -13.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2665
    Cell Significance Index: -76.6700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2677
    Cell Significance Index: -4.4800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3056
    Cell Significance Index: -12.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3443
    Cell Significance Index: -39.4500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3669
    Cell Significance Index: -9.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.4009
    Cell Significance Index: -18.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4083
    Cell Significance Index: -21.2100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4325
    Cell Significance Index: -50.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.4417
    Cell Significance Index: -88.6000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4616
    Cell Significance Index: -16.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5433
    Cell Significance Index: -78.9700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.5573
    Cell Significance Index: -3.4300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.6128
    Cell Significance Index: -43.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6615
    Cell Significance Index: -50.7700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.6901
    Cell Significance Index: -81.3800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.7228
    Cell Significance Index: -20.8300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7321
    Cell Significance Index: -15.8600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.8517
    Cell Significance Index: -88.6800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.9492
    Cell Significance Index: -20.2200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.9560
    Cell Significance Index: -8.0300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9574
    Cell Significance Index: -25.6100
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.9660
    Cell Significance Index: -10.6700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.9978
    Cell Significance Index: -6.2000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.0683
    Cell Significance Index: -84.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.1257
    Cell Significance Index: -31.4600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.2199
    Cell Significance Index: -39.0700
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -1.2640
    Cell Significance Index: -7.8200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.3433
    Cell Significance Index: -75.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.3523
    Cell Significance Index: -83.1200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.4167
    Cell Significance Index: -95.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TIMP1 is a 41-kDa protein with a conserved metalloprotease inhibitory domain. It is widely expressed in various tissues, including connective tissue, epithelial, and endothelial cells. TIMP1 has been shown to interact with MMPs, inhibiting their activity and preventing excessive matrix degradation. Additionally, TIMP1 has been implicated in regulating cell proliferation, differentiation, and survival through its interactions with growth factors and signaling pathways. **Pathways and Functions:** TIMP1 is involved in a wide range of cellular processes, including: 1. **Extracellular matrix regulation**: TIMP1 inhibits MMP activity, preventing excessive matrix degradation and maintaining tissue structure. 2. **Cell growth and differentiation**: TIMP1 regulates cell proliferation and differentiation by interacting with growth factors and signaling pathways. 3. **Apoptosis regulation**: TIMP1 inhibits apoptotic processes by interacting with pro-apoptotic proteins. 4. **Cytokine signaling**: TIMP1 modulates cytokine activity, influencing immune responses and inflammation. 5. **Wound healing**: TIMP1 plays a crucial role in wound healing by regulating matrix remodeling and tissue repair. **Clinical Significance:** TIMP1 has been implicated in various diseases, including: 1. **Cancer**: Elevated TIMP1 expression has been associated with tumor progression and metastasis. 2. **Arthritis**: TIMP1 has been linked to rheumatoid arthritis, with elevated expression contributing to joint destruction. 3. **Cardiovascular disease**: TIMP1 has been implicated in atherosclerosis and cardiovascular disease, with altered expression contributing to disease progression. 4. **Neurological disorders**: TIMP1 has been linked to neurodegenerative diseases, including Alzheimer's and Parkinson's disease. In conclusion, TIMP1 is a multifaceted protein that plays a critical role in regulating various cellular processes, including extracellular matrix regulation, cell growth and differentiation, apoptosis, cytokine signaling, and wound healing. Its dysregulation has been implicated in various diseases, highlighting the importance of TIMP1 in human health and disease. Further research is needed to fully elucidate the role of TIMP1 in these processes and to explore its therapeutic potential.

Genular Protein ID: 1954692007

Symbol: TIMP1_HUMAN

Name: Metalloproteinase inhibitor 1

UniProtKB Accession Codes:

P01033 Q14252 Q9UCU1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 1 CPTC 1 CTD 1 ChEBI 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 27 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 7 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3903517

Title: Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity.

PubMed ID: 3903517

DOI: 10.1038/318066a0

PubMed ID: 3839290

Title: Molecular characterization and expression of the gene encoding human erythroid-potentiating activity.

PubMed ID: 3839290

DOI: 10.1038/315768a0

PubMed ID: 3010309

Title: Primary structure and cDNA cloning of human fibroblast collagenase inhibitor.

PubMed ID: 3010309

DOI: 10.1073/pnas.83.8.2407

PubMed ID: 2171551

Title: Characterization of three abundant mRNAs from human ovarian granulosa cells.

PubMed ID: 2171551

DOI: 10.1089/dna.1990.9.479

PubMed ID: 7507419

Title: Characterization of a human corneal metalloproteinase inhibitor (TIMP-1).

PubMed ID: 7507419

DOI: 10.3109/02713689309020394

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9286280

Title: Genomic organization of the human TIMP-1 gene. Investigation of a causative role in the pathogenesis of X-linked retinitis pigmentosa 2.

PubMed ID: 9286280

PubMed ID: 1730286

Title: Isolation and characterization of tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) from human rheumatoid synovial fluid.

PubMed ID: 1730286

DOI: 10.1016/0014-5793(92)80393-u

PubMed ID: 1653055

Title: The cytokine-protease connection: identification of a 96-kD THP-1 gelatinase and regulation by interleukin-1 and cytokine inducers.

PubMed ID: 1653055

DOI: 10.1016/1043-4666(91)90021-5

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 2163605

Title: Disulphide bond assignment in human tissue inhibitor of metalloproteinases (TIMP).

PubMed ID: 2163605

DOI: 10.1042/bj2680267

PubMed ID: 1420137

Title: Site-directed mutations that alter the inhibitory activity of the tissue inhibitor of metalloproteinases-1: importance of the N-terminal region between cysteine 3 and cysteine 13.

PubMed ID: 1420137

DOI: 10.1021/bi00157a002

PubMed ID: 8541540

Title: Metalloproteinase inhibition and erythroid potentiation are independent activities of tissue inhibitor of metalloproteinases-1.

PubMed ID: 8541540

PubMed ID: 8576151

Title: Biochemical characterization of human collagenase-3.

PubMed ID: 8576151

DOI: 10.1074/jbc.271.3.1544

PubMed ID: 9065415

Title: The role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interaction.

PubMed ID: 9065415

DOI: 10.1074/jbc.272.12.7608

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16917503

Title: Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein.

PubMed ID: 16917503

DOI: 10.1038/sj.emboj.7601281

PubMed ID: 16740002

Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

PubMed ID: 16740002

DOI: 10.1021/pr050492k

PubMed ID: 16263699

Title: Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.

PubMed ID: 16263699

DOI: 10.1074/mcp.m500324-mcp200

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 23522389

Title: Timp1 interacts with beta-1 integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation.

PubMed ID: 23522389

DOI: 10.1186/1476-4598-12-22

PubMed ID: 24635319

Title: TIMP-1 modulates chemotaxis of human neural stem cells through CD63 and integrin signalling.

PubMed ID: 24635319

DOI: 10.1042/bj20131119

PubMed ID: 23982756

Title: Cytokine functions of TIMP-1.

PubMed ID: 23982756

DOI: 10.1007/s00018-013-1457-3

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 9288970

Title: Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1.

PubMed ID: 9288970

DOI: 10.1038/37995

PubMed ID: 10623524

Title: NMR structure of tissue inhibitor of metalloproteinases-1 implicates localized induced fit in recognition of matrix metalloproteinases.

PubMed ID: 10623524

DOI: 10.1006/jmbi.1999.3362

PubMed ID: 12834347

Title: Global orientation of bound MMP-3 and N-TIMP-1 in solution via residual dipolar couplings.

PubMed ID: 12834347

DOI: 10.1021/bi034545s

PubMed ID: 17050530

Title: Crystal structure of the catalytic domain of matrix metalloproteinase-1 in complex with the inhibitory domain of tissue inhibitor of metalloproteinase-1.

PubMed ID: 17050530

DOI: 10.1074/jbc.m607625200

PubMed ID: 20545310

Title: The intrinsic protein flexibility of endogenous protease inhibitor TIMP-1 controls its binding interface and affects its function.

PubMed ID: 20545310

DOI: 10.1021/bi902141x

PubMed ID: 22427646

Title: Matrix metalloproteinase-10 (MMP10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure.

PubMed ID: 22427646

DOI: 10.1074/jbc.m112.341156

Sequence Information:

  • Length: 207
  • Mass: 23171
  • Checksum: 5AE4F90FFAB2ECDC
  • Sequence:
    • MAPFEPLASG ILLLLWLIAP SRACTCVPPH PQTAFCNSDL VIRAKFVGTP EVNQTTLYQR 
YEIKMTKMYK GFQALGDAAD IRFVYTPAME SVCGYFHRSH NRSEEFLIAG KLQDGLLHIT 
TCSFVAPWNS LSLAQRRGFT KTYTVGCEEC TVFPCLSIPC KLQSGTHCLW TDQLLQGSEK 
GFQSRHLACL PREPGLCTWQ SLRSQIA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.