Details for: ZBTB16

Gene ID: 7704

Symbol: ZBTB16

Ensembl ID: ENSG00000109906

Description: zinc finger and BTB domain containing 16

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 487.3181
    Cell Significance Index: -75.8000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 286.4258
    Cell Significance Index: -72.6500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 150.1940
    Cell Significance Index: -70.9100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 139.2222
    Cell Significance Index: -56.5600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 127.9975
    Cell Significance Index: -65.8400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 61.5432
    Cell Significance Index: -75.8800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 26.8986
    Cell Significance Index: -58.8700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 24.8240
    Cell Significance Index: -66.5000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 23.4506
    Cell Significance Index: 158.8900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 19.3219
    Cell Significance Index: -76.2500
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 9.2354
    Cell Significance Index: 81.9800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 8.1859
    Cell Significance Index: 199.7300
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 7.4935
    Cell Significance Index: 94.3600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 5.8954
    Cell Significance Index: 151.5400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 5.5934
    Cell Significance Index: 90.2500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 5.4461
    Cell Significance Index: 417.9300
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 5.1871
    Cell Significance Index: 53.7300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 3.9329
    Cell Significance Index: 66.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.7191
    Cell Significance Index: 1333.9800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 3.3656
    Cell Significance Index: 71.9400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.3392
    Cell Significance Index: 469.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.2781
    Cell Significance Index: 140.0200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.2616
    Cell Significance Index: 44.1400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.0808
    Cell Significance Index: 139.9200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.9210
    Cell Significance Index: 46.0700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.6560
    Cell Significance Index: 47.4700
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 1.3048
    Cell Significance Index: 5.6800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.2950
    Cell Significance Index: 18.6300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.1063
    Cell Significance Index: 18.2300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.0418
    Cell Significance Index: 14.9600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.7990
    Cell Significance Index: 507.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7494
    Cell Significance Index: 148.7200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7314
    Cell Significance Index: 38.1000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7223
    Cell Significance Index: 499.5900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.5637
    Cell Significance Index: 1061.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.5198
    Cell Significance Index: 235.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1714
    Cell Significance Index: 23.5400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1131
    Cell Significance Index: 102.0900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0991
    Cell Significance Index: 5.9500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0929
    Cell Significance Index: 11.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0440
    Cell Significance Index: 2.4700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0439
    Cell Significance Index: 0.7700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0373
    Cell Significance Index: 7.1000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.0262
    Cell Significance Index: 2.7200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0029
    Cell Significance Index: 0.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0025
    Cell Significance Index: -0.4500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0036
    Cell Significance Index: -6.6600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0158
    Cell Significance Index: -11.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0335
    Cell Significance Index: -51.5000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0434
    Cell Significance Index: -1.1800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0488
    Cell Significance Index: -66.3200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0528
    Cell Significance Index: -0.7800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0681
    Cell Significance Index: -7.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0696
    Cell Significance Index: -4.2700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0812
    Cell Significance Index: -61.4300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0821
    Cell Significance Index: -36.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0914
    Cell Significance Index: -14.8700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0938
    Cell Significance Index: -3.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1030
    Cell Significance Index: -76.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1033
    Cell Significance Index: -10.5500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1220
    Cell Significance Index: -3.0500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1266
    Cell Significance Index: -79.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1383
    Cell Significance Index: -78.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.1388
    Cell Significance Index: -75.7800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1775
    Cell Significance Index: -25.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1976
    Cell Significance Index: -33.7400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1984
    Cell Significance Index: -25.4300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1987
    Cell Significance Index: -25.6800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2174
    Cell Significance Index: -6.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2206
    Cell Significance Index: -63.4800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2313
    Cell Significance Index: -16.0000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2532
    Cell Significance Index: -5.4800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2594
    Cell Significance Index: -19.3300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2937
    Cell Significance Index: -14.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3601
    Cell Significance Index: -16.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.3776
    Cell Significance Index: -37.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3821
    Cell Significance Index: -80.4900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4420
    Cell Significance Index: -6.5300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5064
    Cell Significance Index: -58.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5579
    Cell Significance Index: -26.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.5672
    Cell Significance Index: -25.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.5781
    Cell Significance Index: -68.1800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6221
    Cell Significance Index: -49.2700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6535
    Cell Significance Index: -76.1600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.7262
    Cell Significance Index: -51.3600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.7685
    Cell Significance Index: -49.5800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7834
    Cell Significance Index: -41.1300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.8667
    Cell Significance Index: -17.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.8821
    Cell Significance Index: -25.4200
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.9686
    Cell Significance Index: -13.5500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.2853
    Cell Significance Index: -81.0100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.2885
    Cell Significance Index: -41.2700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.2924
    Cell Significance Index: -41.1600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -1.2965
    Cell Significance Index: -16.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.3310
    Cell Significance Index: -69.1400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.3973
    Cell Significance Index: -30.1900
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -1.3998
    Cell Significance Index: -21.3000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.4362
    Cell Significance Index: -47.0200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.4590
    Cell Significance Index: -51.1100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.5074
    Cell Significance Index: -52.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Zinc finger and BTB domain structure:** ZBTB16 possesses a characteristic zinc finger and BTB domain, which are essential for its DNA-binding and transcriptional regulatory functions. 2. **Transcriptional repressor activity:** ZBTB16 acts as a transcriptional repressor, binding to specific DNA sequences and inhibiting the transcription of target genes. 3. **Multi-faceted cellular expression:** ZBTB16 is expressed in a wide range of cell types, including immune cells, muscle cells, and epithelial cells, underscoring its diverse roles in cellular regulation. 4. **Regulation of immune responses:** ZBTB16 is involved in the regulation of immune responses, including antigen processing and presentation, cell proliferation, and apoptosis. **Pathways and Functions:** 1. **Adaptive immune system:** ZBTB16 regulates the adaptive immune response by modulating the expression of genes involved in antigen processing and presentation. 2. **Anterior/posterior pattern specification:** ZBTB16 plays a role in the specification of anterior/posterior body patterns during embryonic development. 3. **Apoptotic process:** ZBTB16 promotes apoptosis in certain cell types, regulating cell death and tissue homeostasis. 4. **Cell population proliferation:** ZBTB16 inhibits cell proliferation in certain contexts, regulating tissue growth and development. 5. **Central nervous system development:** ZBTB16 is involved in the development of the central nervous system, regulating the specification of neuronal cell types. 6. **Class I MHC-mediated antigen processing and presentation:** ZBTB16 regulates the expression of class I MHC molecules, influencing antigen processing and presentation. **Clinical Significance:** 1. **Immune-related disorders:** Aberrant ZBTB16 expression has been implicated in various immune-related disorders, including autoimmune diseases and cancer. 2. **Developmental abnormalities:** Mutations in ZBTB16 have been linked to developmental abnormalities, including congenital defects and cancer. 3. **Cancer therapy:** Targeting ZBTB16 may offer a new therapeutic strategy for cancer treatment, particularly in the context of immune-related cancer. 4. **Regenerative medicine:** ZBTB16's role in cell proliferation and differentiation makes it a potential target for regenerative medicine applications. In conclusion, ZBTB16 is a complex gene with far-reaching implications for our understanding of immune regulation and developmental processes. Further research into the mechanisms by which ZBTB16 influences these processes will provide valuable insights into the underlying biology of human disease and may ultimately lead to the development of novel therapeutic strategies.

Genular Protein ID: 1297545484

Symbol: ZBT16_HUMAN

Name: Zinc finger and BTB domain-containing protein 16

UniProtKB Accession Codes:

Q05516 Q8TAL4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 46 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 5 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8384553

Title: Fusion between a novel Kruppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia.

PubMed ID: 8384553

DOI: 10.1002/j.1460-2075.1993.tb05757.x

PubMed ID: 10500192

Title: Genomic sequence, structural organization, molecular evolution, and aberrant rearrangement of promyelocytic leukemia zinc finger gene.

PubMed ID: 10500192

DOI: 10.1073/pnas.96.20.11422

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8387545

Title: Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia.

PubMed ID: 8387545

DOI: 10.1172/jci116453

PubMed ID: 10572087

Title: A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF.

PubMed ID: 10572087

PubMed ID: 10688654

Title: The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein.

PubMed ID: 10688654

DOI: 10.1128/mcb.20.6.2075-2086.2000

PubMed ID: 11161217

Title: Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis.

PubMed ID: 11161217

DOI: 10.1126/science.291.5506.1047

PubMed ID: 14528312

Title: Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases.

PubMed ID: 14528312

DOI: 10.1038/ncb1056

PubMed ID: 16676348

Title: A new hepatocytic isoform of PLZF lacking the BTB domain interacts with ATP7B, the Wilson disease protein, and positively regulates ERK signal transduction.

PubMed ID: 16676348

DOI: 10.1002/jcb.20980

PubMed ID: 24359566

Title: Analysis of the interaction between Zinc finger protein 179 (Znf179) and promyelocytic leukemia zinc finger (Plzf).

PubMed ID: 24359566

DOI: 10.1186/1423-0127-20-98

PubMed ID: 9770450

Title: Crystal structure of the BTB domain from PLZF.

PubMed ID: 9770450

DOI: 10.1073/pnas.95.21.12123

PubMed ID: 10537309

Title: Structure-function studies of the BTB/POZ transcriptional repression domain from the promyelocytic leukemia zinc finger oncoprotein.

PubMed ID: 10537309

PubMed ID: 18611983

Title: Biallelic loss of function of the promyelocytic leukaemia zinc finger (PLZF) gene causes severe skeletal defects and genital hypoplasia.

PubMed ID: 18611983

DOI: 10.1136/jmg.2008.059451

Sequence Information:

  • Length: 673
  • Mass: 74274
  • Checksum: 51F8E361FA31239E
  • Sequence:
    • MDLTKMGMIQ LQNPSHPTGL LCKANQMRLA GTLCDVVIMV DSQEFHAHRT VLACTSKMFE 
ILFHRNSQHY TLDFLSPKTF QQILEYAYTA TLQAKAEDLD DLLYAAEILE IEYLEEQCLK 
MLETIQASDD NDTEATMADG GAEEEEDRKA RYLKNIFISK HSSEESGYAS VAGQSLPGPM 
VDQSPSVSTS FGLSAMSPTK AAVDSLMTIG QSLLQGTLQP PAGPEEPTLA GGGRHPGVAE 
VKTEMMQVDE VPSQDSPGAA ESSISGGMGD KVEERGKEGP GTPTRSSVIT SARELHYGRE 
ESAEQVPPPA EAGQAPTGRP EHPAPPPEKH LGIYSVLPNH KADAVLSMPS SVTSGLHVQP 
ALAVSMDFST YGGLLPQGFI QRELFSKLGE LAVGMKSESR TIGEQCSVCG VELPDNEAVE 
QHRKLHSGMK TYGCELCGKR FLDSLRLRMH LLAHSAGAKA FVCDQCGAQF SKEDALETHR 
QTHTGTDMAV FCLLCGKRFQ AQSALQQHME VHAGVRSYIC SECNRTFPSH TALKRHLRSH 
TGDHPYECEF CGSCFRDEST LKSHKRIHTG EKPYECNGCG KKFSLKHQLE THYRVHTGEK 
PFECKLCHQR SRDYSAMIKH LRTHNGASPY QCTICTEYCP SLSSMQKHMK GHKPEEIPPD 
WRIEKTYLYL CYV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.