Details for: ZBTB16

Gene ID: 7704

Symbol: ZBTB16

Ensembl ID: ENSG00000109906

Description: zinc finger and BTB domain containing 16

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 7.56
    Marker Score: 4975
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 7.11
    Marker Score: 17807
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 5.98
    Marker Score: 3325
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 5.61
    Marker Score: 3038
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 4.7
    Marker Score: 5851
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 4.37
    Marker Score: 3877
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 3.89
    Marker Score: 86963
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 3.76
    Marker Score: 1375
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 3.55
    Marker Score: 12620.5
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 3.55
    Marker Score: 920
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 3.41
    Marker Score: 3922.5
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 3.02
    Marker Score: 5804
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.83
    Marker Score: 1687
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.83
    Marker Score: 10033
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.82
    Marker Score: 1575
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.81
    Marker Score: 21564
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.8
    Marker Score: 59785
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.8
    Marker Score: 4052.5
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.8
    Marker Score: 2669
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.8
    Marker Score: 6144
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.79
    Marker Score: 41666.5
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.77
    Marker Score: 7029.5
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.76
    Marker Score: 4007
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.72
    Marker Score: 793.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.68
    Marker Score: 101725
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.57
    Marker Score: 1269
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 2.55
    Marker Score: 1114
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.55
    Marker Score: 10657.5
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.49
    Marker Score: 788
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.48
    Marker Score: 1308
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.35
    Marker Score: 2513.5
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.34
    Marker Score: 6689
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.28
    Marker Score: 8814.5
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.27
    Marker Score: 45059
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.25
    Marker Score: 1312
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.17
    Marker Score: 20376
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 2.16
    Marker Score: 677
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.14
    Marker Score: 79079
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.11
    Marker Score: 33872
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.09
    Marker Score: 8664
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.08
    Marker Score: 70626
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.06
    Marker Score: 126845
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.06
    Marker Score: 2198
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.03
    Marker Score: 3402
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 2.01
    Marker Score: 2166.5
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.91
    Marker Score: 439
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.87
    Marker Score: 705
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.87
    Marker Score: 17750.5
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.85
    Marker Score: 670
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.83
    Marker Score: 426
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.82
    Marker Score: 1267
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.82
    Marker Score: 15634
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.81
    Marker Score: 8909.5
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.79
    Marker Score: 7729
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.76
    Marker Score: 9475.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.74
    Marker Score: 4096
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.71
    Marker Score: 1470
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.69
    Marker Score: 3180
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.68
    Marker Score: 1460
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.68
    Marker Score: 540
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.66
    Marker Score: 10672.5
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.66
    Marker Score: 3966.5
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.65
    Marker Score: 419
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.63
    Marker Score: 793
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.61
    Marker Score: 2480
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.58
    Marker Score: 585
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.56
    Marker Score: 1935
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.54
    Marker Score: 6659
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 1.53
    Marker Score: 389
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.52
    Marker Score: 569
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.51
    Marker Score: 909
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.49
    Marker Score: 369
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.48
    Marker Score: 3874
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.47
    Marker Score: 465
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.45
    Marker Score: 956
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166594
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1.43
    Marker Score: 513
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.42
    Marker Score: 375
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.4
    Marker Score: 707
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.38
    Marker Score: 805
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.38
    Marker Score: 1175
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.37
    Marker Score: 590
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.36
    Marker Score: 21309
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.34
    Marker Score: 2063
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.33
    Marker Score: 877
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.33
    Marker Score: 2255
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.31
    Marker Score: 8527
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.3
    Marker Score: 3138
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 1.28
    Marker Score: 3617
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.28
    Marker Score: 351
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.27
    Marker Score: 1402.5
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.27
    Marker Score: 739
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.26
    Marker Score: 567
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1.24
    Marker Score: 272
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.23
    Marker Score: 443
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.21
    Marker Score: 822
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 1.21
    Marker Score: 364
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.2
    Marker Score: 407
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.19
    Marker Score: 343
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.18
    Marker Score: 1331.5

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key Characteristics:** 1. **Zinc finger and BTB domain structure:** ZBTB16 possesses a characteristic zinc finger and BTB domain, which are essential for its DNA-binding and transcriptional regulatory functions. 2. **Transcriptional repressor activity:** ZBTB16 acts as a transcriptional repressor, binding to specific DNA sequences and inhibiting the transcription of target genes. 3. **Multi-faceted cellular expression:** ZBTB16 is expressed in a wide range of cell types, including immune cells, muscle cells, and epithelial cells, underscoring its diverse roles in cellular regulation. 4. **Regulation of immune responses:** ZBTB16 is involved in the regulation of immune responses, including antigen processing and presentation, cell proliferation, and apoptosis. **Pathways and Functions:** 1. **Adaptive immune system:** ZBTB16 regulates the adaptive immune response by modulating the expression of genes involved in antigen processing and presentation. 2. **Anterior/posterior pattern specification:** ZBTB16 plays a role in the specification of anterior/posterior body patterns during embryonic development. 3. **Apoptotic process:** ZBTB16 promotes apoptosis in certain cell types, regulating cell death and tissue homeostasis. 4. **Cell population proliferation:** ZBTB16 inhibits cell proliferation in certain contexts, regulating tissue growth and development. 5. **Central nervous system development:** ZBTB16 is involved in the development of the central nervous system, regulating the specification of neuronal cell types. 6. **Class I MHC-mediated antigen processing and presentation:** ZBTB16 regulates the expression of class I MHC molecules, influencing antigen processing and presentation. **Clinical Significance:** 1. **Immune-related disorders:** Aberrant ZBTB16 expression has been implicated in various immune-related disorders, including autoimmune diseases and cancer. 2. **Developmental abnormalities:** Mutations in ZBTB16 have been linked to developmental abnormalities, including congenital defects and cancer. 3. **Cancer therapy:** Targeting ZBTB16 may offer a new therapeutic strategy for cancer treatment, particularly in the context of immune-related cancer. 4. **Regenerative medicine:** ZBTB16's role in cell proliferation and differentiation makes it a potential target for regenerative medicine applications. In conclusion, ZBTB16 is a complex gene with far-reaching implications for our understanding of immune regulation and developmental processes. Further research into the mechanisms by which ZBTB16 influences these processes will provide valuable insights into the underlying biology of human disease and may ultimately lead to the development of novel therapeutic strategies.

Genular Protein ID: 1297545484

Symbol: ZBT16_HUMAN

Name: Zinc finger and BTB domain-containing protein 16

UniProtKB Accession Codes:

Q05516 Q8TAL4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 46 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 5 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8384553

Title: Fusion between a novel Kruppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia.

PubMed ID: 8384553

DOI: 10.1002/j.1460-2075.1993.tb05757.x

PubMed ID: 10500192

Title: Genomic sequence, structural organization, molecular evolution, and aberrant rearrangement of promyelocytic leukemia zinc finger gene.

PubMed ID: 10500192

DOI: 10.1073/pnas.96.20.11422

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8387545

Title: Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia.

PubMed ID: 8387545

DOI: 10.1172/jci116453

PubMed ID: 10572087

Title: A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF.

PubMed ID: 10572087

PubMed ID: 10688654

Title: The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein.

PubMed ID: 10688654

DOI: 10.1128/mcb.20.6.2075-2086.2000

PubMed ID: 11161217

Title: Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis.

PubMed ID: 11161217

DOI: 10.1126/science.291.5506.1047

PubMed ID: 14528312

Title: Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases.

PubMed ID: 14528312

DOI: 10.1038/ncb1056

PubMed ID: 16676348

Title: A new hepatocytic isoform of PLZF lacking the BTB domain interacts with ATP7B, the Wilson disease protein, and positively regulates ERK signal transduction.

PubMed ID: 16676348

DOI: 10.1002/jcb.20980

PubMed ID: 24359566

Title: Analysis of the interaction between Zinc finger protein 179 (Znf179) and promyelocytic leukemia zinc finger (Plzf).

PubMed ID: 24359566

DOI: 10.1186/1423-0127-20-98

PubMed ID: 9770450

Title: Crystal structure of the BTB domain from PLZF.

PubMed ID: 9770450

DOI: 10.1073/pnas.95.21.12123

PubMed ID: 10537309

Title: Structure-function studies of the BTB/POZ transcriptional repression domain from the promyelocytic leukemia zinc finger oncoprotein.

PubMed ID: 10537309

PubMed ID: 18611983

Title: Biallelic loss of function of the promyelocytic leukaemia zinc finger (PLZF) gene causes severe skeletal defects and genital hypoplasia.

PubMed ID: 18611983

DOI: 10.1136/jmg.2008.059451

Sequence Information:

  • Length: 673
  • Mass: 74274
  • Checksum: 51F8E361FA31239E
  • Sequence:
    • MDLTKMGMIQ LQNPSHPTGL LCKANQMRLA GTLCDVVIMV DSQEFHAHRT VLACTSKMFE 
ILFHRNSQHY TLDFLSPKTF QQILEYAYTA TLQAKAEDLD DLLYAAEILE IEYLEEQCLK 
MLETIQASDD NDTEATMADG GAEEEEDRKA RYLKNIFISK HSSEESGYAS VAGQSLPGPM 
VDQSPSVSTS FGLSAMSPTK AAVDSLMTIG QSLLQGTLQP PAGPEEPTLA GGGRHPGVAE 
VKTEMMQVDE VPSQDSPGAA ESSISGGMGD KVEERGKEGP GTPTRSSVIT SARELHYGRE 
ESAEQVPPPA EAGQAPTGRP EHPAPPPEKH LGIYSVLPNH KADAVLSMPS SVTSGLHVQP 
ALAVSMDFST YGGLLPQGFI QRELFSKLGE LAVGMKSESR TIGEQCSVCG VELPDNEAVE 
QHRKLHSGMK TYGCELCGKR FLDSLRLRMH LLAHSAGAKA FVCDQCGAQF SKEDALETHR 
QTHTGTDMAV FCLLCGKRFQ AQSALQQHME VHAGVRSYIC SECNRTFPSH TALKRHLRSH 
TGDHPYECEF CGSCFRDEST LKSHKRIHTG EKPYECNGCG KKFSLKHQLE THYRVHTGEK 
PFECKLCHQR SRDYSAMIKH LRTHNGASPY QCTICTEYCP SLSSMQKHMK GHKPEEIPPD 
WRIEKTYLYL CYV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.