Details for: GNA15

Gene ID: 2769

Symbol: GNA15

Ensembl ID: ENSG00000060558

Description: G protein subunit alpha 15

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 4.92
    Marker Score: 3940
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.13
    Marker Score: 1677
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.04
    Marker Score: 8344
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.97
    Marker Score: 961
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.91
    Marker Score: 1386
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.75
    Marker Score: 4273
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.69
    Marker Score: 14548
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.68
    Marker Score: 13096
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.62
    Marker Score: 3068
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.6
    Marker Score: 401
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.59
    Marker Score: 2340
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.59
    Marker Score: 1917
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.58
    Marker Score: 1079
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.48
    Marker Score: 14986
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.35
    Marker Score: 434
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.3
    Marker Score: 617
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.3
    Marker Score: 1484
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.3
    Marker Score: 646
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.29
    Marker Score: 878.5
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.24
    Marker Score: 837
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.2
    Marker Score: 7662
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.18
    Marker Score: 652
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.15
    Marker Score: 839
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4780
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.13
    Marker Score: 1189
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.1
    Marker Score: 660
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.1
    Marker Score: 4229
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.07
    Marker Score: 524
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.07
    Marker Score: 2769.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.05
    Marker Score: 666
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251764
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.04
    Marker Score: 363
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71781
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48006
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.98
    Marker Score: 54941
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.98
    Marker Score: 995
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 498
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.96
    Marker Score: 398
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 451
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.95
    Marker Score: 241
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.94
    Marker Score: 1330
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.93
    Marker Score: 1820
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.91
    Marker Score: 23365
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.91
    Marker Score: 372
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 365
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2728
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5039
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5273
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.85
    Marker Score: 5183
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.83
    Marker Score: 411
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.83
    Marker Score: 555
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.82
    Marker Score: 215
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.8
    Marker Score: 422
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.8
    Marker Score: 275
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.8
    Marker Score: 192
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.79
    Marker Score: 355
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1245
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.76
    Marker Score: 258
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 579
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.75
    Marker Score: 511
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 387
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.75
    Marker Score: 514
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.74
    Marker Score: 239
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.74
    Marker Score: 364
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 669
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.73
    Marker Score: 898
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.72
    Marker Score: 601
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.7
    Marker Score: 1746
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.7
    Marker Score: 284
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.69
    Marker Score: 297
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.69
    Marker Score: 471
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.69
    Marker Score: 394
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.68
    Marker Score: 190
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.66
    Marker Score: 192
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.65
    Marker Score: 755
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.64
    Marker Score: 373
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.64
    Marker Score: 298
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.64
    Marker Score: 1018
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.63
    Marker Score: 816
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.59
    Marker Score: 657
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 0.59
    Marker Score: 448
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.59
    Marker Score: 378.5
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.57
    Marker Score: 636
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 151
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.56
    Marker Score: 987
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 232
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.54
    Marker Score: 227
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.53
    Marker Score: 1446
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.53
    Marker Score: 1461
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.53
    Marker Score: 351
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.52
    Marker Score: 302
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.52
    Marker Score: 338
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.51
    Marker Score: 161
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.51
    Marker Score: 513
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.51
    Marker Score: 214

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Other Information

**Key characteristics:** - The GNA15 gene is located on chromosome 17q21.1. - It is a large gene with a molecular weight of approximately 120 kDa. - GNA15 protein is a type I G protein-coupled receptor. **Pathways and functions:** - GNA15 is involved in the regulation of insulin secretion through the following pathways: - Acetylcholine regulates insulin secretion through the muscarinic cholinergic receptor G protein alpha (G alpha (i)). - Adp signalling through p2y purinoceptor 1. - Chaperonin-mediated protein folding. - Cooperation of pdcl (phlp1) and tric/cct in g-protein beta folding. - Free fatty acids regulate insulin secretion. - G alpha (i) signalling events. - G alpha (q) signalling events. - Gpcr downstream signalling. - GNA15 also plays a role in hemostasis, energy metabolism, platelet activation, and signalling. **Clinical significance:** - Mutations in GNA15 have been linked to type 2 diabetes, obesity, and metabolic syndrome. - Genetic variants in GNA15 have been associated with variations in insulin sensitivity and glucose metabolism. - Targeting GNA15 signaling has emerged as a potential therapeutic strategy for diabetes.

Genular Protein ID: 3945718418

Symbol: GNA15_HUMAN

Name: Guanine nucleotide-binding protein subunit alpha-15

UniProtKB Accession Codes:

P30679 E9KL40 E9KL47 O75247 Q53XK2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 7 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 3 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 9 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1905813

Title: G alpha 16, a G protein alpha subunit specifically expressed in hematopoietic cells.

PubMed ID: 1905813

DOI: 10.1073/pnas.88.13.5587

PubMed ID: 20736409

Title: Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins.

PubMed ID: 20736409

DOI: 10.1074/mcp.m110.001719

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 374
  • Mass: 43508
  • Checksum: 8127AC16FC212507
  • Sequence:
    • MARSLTWRCC PWCLTEDEKA AARVDQEINR ILLEQKKQDR GELKLLLLGP GESGKSTFIK 
QMRIIHGAGY SEEERKGFRP LVYQNIFVSM RAMIEAMERL QIPFSRPESK HHASLVMSQD 
PYKVTTFEKR YAAAMQWLWR DAGIRACYER RREFHLLDSA VYYLSHLERI TEEGYVPTAQ 
DVLRSRMPTT GINEYCFSVQ KTNLRIVDVG GQKSERKKWI HCFENVIALI YLASLSEYDQ 
CLEENNQENR MKESLALFGT ILELPWFKST SVILFLNKTD ILEEKIPTSH LATYFPSFQG 
PKQDAEAAKR FILDMYTRMY TGCVDGPEGS KKGARSRRLF SHYTCATDTQ NIRKVFKDVR 
DSVLARYLDE INLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.