Details for: PKM

Gene ID: 5315

Symbol: PKM

Ensembl ID: ENSG00000067225

Description: pyruvate kinase M1/2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 833.6482
    Cell Significance Index: -129.6700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 429.1853
    Cell Significance Index: -108.8600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 317.1277
    Cell Significance Index: -130.6400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 268.8920
    Cell Significance Index: -126.9500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 239.2954
    Cell Significance Index: -123.0900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 189.7106
    Cell Significance Index: -127.3000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 105.2349
    Cell Significance Index: -129.7500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 37.1941
    Cell Significance Index: -114.2400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 33.4385
    Cell Significance Index: -131.9500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 28.1015
    Cell Significance Index: -75.2800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 20.5064
    Cell Significance Index: -44.8800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 12.4572
    Cell Significance Index: 654.0500
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 8.5413
    Cell Significance Index: 73.4000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 8.1903
    Cell Significance Index: 63.1300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 7.7979
    Cell Significance Index: 2243.6900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.8113
    Cell Significance Index: 332.7300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.4908
    Cell Significance Index: 131.8900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.3787
    Cell Significance Index: 80.9300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 4.3416
    Cell Significance Index: 150.8700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 4.1700
    Cell Significance Index: 491.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 4.0743
    Cell Significance Index: 2225.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.8558
    Cell Significance Index: 695.0800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.6897
    Cell Significance Index: 100.4300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.4204
    Cell Significance Index: 420.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.1696
    Cell Significance Index: 236.2300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 3.0909
    Cell Significance Index: 82.6800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.8907
    Cell Significance Index: 23.0800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.5241
    Cell Significance Index: 27.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.5190
    Cell Significance Index: 118.3900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.3658
    Cell Significance Index: 66.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.0846
    Cell Significance Index: 108.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0265
    Cell Significance Index: 406.5200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.9501
    Cell Significance Index: 122.9100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.6910
    Cell Significance Index: 747.6100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.6881
    Cell Significance Index: 15.5500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.6733
    Cell Significance Index: 44.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.4743
    Cell Significance Index: 68.7400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.4736
    Cell Significance Index: 104.2200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.4700
    Cell Significance Index: 39.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.3403
    Cell Significance Index: 184.0600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.3372
    Cell Significance Index: 171.4200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.2893
    Cell Significance Index: 166.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2484
    Cell Significance Index: 203.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0460
    Cell Significance Index: 375.2000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.9084
    Cell Significance Index: 26.0400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8027
    Cell Significance Index: 724.7600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7663
    Cell Significance Index: 49.4400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.6586
    Cell Significance Index: 15.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6095
    Cell Significance Index: 120.9600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4729
    Cell Significance Index: 90.0000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3794
    Cell Significance Index: 8.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3660
    Cell Significance Index: 689.1400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3441
    Cell Significance Index: 20.6600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3421
    Cell Significance Index: 7.1600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3107
    Cell Significance Index: 3.5300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.3000
    Cell Significance Index: 219.9700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1871
    Cell Significance Index: 288.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1554
    Cell Significance Index: 286.6200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1527
    Cell Significance Index: 96.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1411
    Cell Significance Index: 106.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0523
    Cell Significance Index: 71.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0485
    Cell Significance Index: 8.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0429
    Cell Significance Index: 19.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0071
    Cell Significance Index: 0.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0179
    Cell Significance Index: -1.8300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0288
    Cell Significance Index: -17.9800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0333
    Cell Significance Index: -1.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0467
    Cell Significance Index: -34.5800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0672
    Cell Significance Index: -1.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0682
    Cell Significance Index: -1.9700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0944
    Cell Significance Index: -7.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1595
    Cell Significance Index: -89.9500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1933
    Cell Significance Index: -22.0600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2715
    Cell Significance Index: -57.1900
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.2838
    Cell Significance Index: -2.5000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2923
    Cell Significance Index: -5.0100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3089
    Cell Significance Index: -20.7700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3624
    Cell Significance Index: -4.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3865
    Cell Significance Index: -21.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3873
    Cell Significance Index: -56.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4127
    Cell Significance Index: -47.2800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6893
    Cell Significance Index: -54.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6908
    Cell Significance Index: -80.5100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7183
    Cell Significance Index: -9.8000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7253
    Cell Significance Index: -23.2300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.7460
    Cell Significance Index: -73.8000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8232
    Cell Significance Index: -21.0300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.9394
    Cell Significance Index: -16.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.0902
    Cell Significance Index: -113.5200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.5310
    Cell Significance Index: -67.7200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.6039
    Cell Significance Index: -45.7700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.8839
    Cell Significance Index: -50.4800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -1.9812
    Cell Significance Index: -12.3100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.0483
    Cell Significance Index: -60.3300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.0512
    Cell Significance Index: -125.7600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -2.0659
    Cell Significance Index: -126.9800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -2.1023
    Cell Significance Index: -79.6100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -2.1404
    Cell Significance Index: -111.4900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -2.3087
    Cell Significance Index: -39.8000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -2.4195
    Cell Significance Index: -14.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PKM is a glycolytic enzyme that catalyzes the conversion of phosphoenolpyruvate (PEP) to pyruvate, generating ATP in the process. The M1 and M2 subunits of PKM exhibit distinct characteristics, with M1 being more efficient in catalyzing the glycolytic pathway and M2 being more efficient in inhibiting the pathway. The M1 subunit is also more sensitive to allosteric regulation by ATP, whereas the M2 subunit is more sensitive to allosteric regulation by ADP. These differences in subunit-specific properties enable PKM to fine-tune glycolytic flux in response to changing energy demands. **Pathways and Functions** PKM is involved in multiple cellular pathways, including: 1. **Glycolysis**: PKM is a key enzyme in the glycolytic pathway, catalyzing the conversion of PEP to pyruvate. 2. **Energy metabolism**: PKM plays a critical role in regulating energy metabolism, particularly in high-energy-demanding tissues. 3. **Insulin signaling**: PKM is regulated by insulin, which modulates glycolytic flux in response to changes in glucose availability. 4. **Cellular stress response**: PKM is involved in the cellular stress response, particularly in response to hypoxia and oxidative stress. 5. **Immune response**: PKM is expressed in immune cells, such as monocytes and macrophages, where it regulates glycolytic flux in response to immune stimuli. **Clinical Significance** Dysregulation of PKM has been implicated in various diseases, including: 1. **Cancer**: PKM overexpression has been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Neurodegenerative disorders**: PKM has been implicated in neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Metabolic disorders**: PKM dysregulation has been linked to metabolic disorders, such as type 2 diabetes and obesity. 4. **Inflammatory disorders**: PKM has been implicated in inflammatory disorders, such as rheumatoid arthritis and atherosclerosis. In summary, PKM is a critical enzyme involved in regulating glycolytic flux and energy metabolism in various tissues. Its dysregulation has been implicated in various diseases, highlighting the importance of PKM in maintaining cellular homeostasis and preventing disease.

Genular Protein ID: 655614685

Symbol: KPYM_HUMAN

Name: Pyruvate kinase PKM

UniProtKB Accession Codes:

P14618 A6NFK3 B2R5N8 B3KRY0 B4DFX8 B4DUU6 P14786 Q53GK4 Q96E76 Q9BWB5 Q9UCV6 Q9UPF2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTAC 1 CPTC 1 CTD 1 ChEBI 38 ChEMBL 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 11 DrugCentral 1 EC 4 EMBL 18 EMDB 4 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 32 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 MoonDB 1 MoonProt 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 55 PDBsum 55 PIR 2 PRIDE 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 4 RefSeq 10 Rhea 11 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2854097

Title: Human M2-type pyruvate kinase: cDNA cloning, chromosomal assignment and expression in hepatoma.

PubMed ID: 2854097

DOI: 10.1016/0378-1119(88)90515-x

PubMed ID: 2813362

Title: Cytosolic thyroid hormone-binding protein is a monomer of pyruvate kinase.

PubMed ID: 2813362

DOI: 10.1073/pnas.86.20.7861

PubMed ID: 2040271

Title: Isolation and characterization of the human pyruvate kinase M gene.

PubMed ID: 2040271

DOI: 10.1111/j.1432-1033.1991.tb15991.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1854723

Title: An in vitro novel mechanism of regulating the activity of pyruvate kinase M2 by thyroid hormone and fructose 1, 6-bisphosphate.

PubMed ID: 1854723

DOI: 10.1021/bi00243a010

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 25263439

Title: TRIM35 Interacts with pyruvate kinase isoform M2 to suppress the Warburg effect and tumorigenicity in hepatocellular carcinoma.

PubMed ID: 25263439

DOI: 10.1038/onc.2014.325

PubMed ID: 9466265

Title: Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth.

PubMed ID: 9466265

DOI: 10.1046/j.1365-2958.1998.00670.x

PubMed ID: 12650930

Title: Interaction between HERC1 and M2-type pyruvate kinase.

PubMed ID: 12650930

DOI: 10.1016/s0014-5793(03)00205-9

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 16139798

Title: Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.

PubMed ID: 16139798

DOI: 10.1016/j.bbrc.2005.08.132

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17308100

Title: Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death.

PubMed ID: 17308100

DOI: 10.1158/0008-5472.can-06-2870

PubMed ID: 18298799

Title: Modulation of M2-type pyruvate kinase activity by the cytoplasmic PML tumor suppressor protein.

PubMed ID: 18298799

DOI: 10.1111/j.1365-2443.2008.01165.x

PubMed ID: 18191611

Title: Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription.

PubMed ID: 18191611

DOI: 10.1016/j.biocel.2007.11.009

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18337823

Title: The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.

PubMed ID: 18337823

DOI: 10.1038/nature06734

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20847263

Title: Evidence for an alternative glycolytic pathway in rapidly proliferating cells.

PubMed ID: 20847263

DOI: 10.1126/science.1188015

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21620138

Title: Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1.

PubMed ID: 21620138

DOI: 10.1016/j.cell.2011.03.054

PubMed ID: 21483450

Title: The oxygen sensor PHD3 limits glycolysis under hypoxia via direct binding to pyruvate kinase.

PubMed ID: 21483450

DOI: 10.1038/cr.2011.66

PubMed ID: 21700219

Title: Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth.

PubMed ID: 21700219

DOI: 10.1016/j.molcel.2011.04.025

PubMed ID: 22056988

Title: Nuclear PKM2 regulates beta-catenin transactivation upon EGFR activation.

PubMed ID: 22056988

DOI: 10.1038/nature10598

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22901803

Title: PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis.

PubMed ID: 22901803

DOI: 10.1016/j.cell.2012.07.018

PubMed ID: 22306293

Title: Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase.

PubMed ID: 22306293

DOI: 10.1016/j.molcel.2012.01.001

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24120661

Title: Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization.

PubMed ID: 24120661

DOI: 10.1016/j.molcel.2013.09.004

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27199445

Title: JMJD8 Regulates Angiogenic Sprouting and Cellular Metabolism by Interacting With Pyruvate Kinase M2 in Endothelial Cells.

PubMed ID: 27199445

DOI: 10.1161/atvbaha.116.307695

PubMed ID: 27573352

Title: TSC22D2 interacts with PKM2 and inhibits cell growth in colorectal cancer.

PubMed ID: 27573352

DOI: 10.3892/ijo.2016.3599

PubMed ID: 26787900

Title: SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions.

PubMed ID: 26787900

DOI: 10.1073/pnas.1520045113

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30487609

Title: Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury.

PubMed ID: 30487609

DOI: 10.1038/s41586-018-0749-z

PubMed ID: 32268273

Title: TRAF4 acts as a fate checkpoint to regulate the adipogenic differentiation of MSCs by activating PKM2.

PubMed ID: 32268273

DOI: 10.1016/j.ebiom.2020.102722

PubMed ID: 15996096

Title: Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis.

PubMed ID: 15996096

DOI: 10.1021/bi0474923

PubMed ID: 18337815

Title: Pyruvate kinase M2 is a phosphotyrosine-binding protein.

PubMed ID: 18337815

DOI: 10.1038/nature06667

PubMed ID: 23064226

Title: Serine is a natural ligand and allosteric activator of pyruvate kinase M2.

PubMed ID: 23064226

DOI: 10.1038/nature11540

PubMed ID: 23530218

Title: M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation.

PubMed ID: 23530218

DOI: 10.1073/pnas.1217157110

Sequence Information:

  • Length: 531
  • Mass: 57937
  • Checksum: AA94D7818ED6BBAD
  • Sequence:
    • MSKPHSEAGT AFIQTQQLHA AMADTFLEHM CRLDIDSPPI TARNTGIICT IGPASRSVET 
LKEMIKSGMN VARLNFSHGT HEYHAETIKN VRTATESFAS DPILYRPVAV ALDTKGPEIR 
TGLIKGSGTA EVELKKGATL KITLDNAYME KCDENILWLD YKNICKVVEV GSKIYVDDGL 
ISLQVKQKGA DFLVTEVENG GSLGSKKGVN LPGAAVDLPA VSEKDIQDLK FGVEQDVDMV 
FASFIRKASD VHEVRKVLGE KGKNIKIISK IENHEGVRRF DEILEASDGI MVARGDLGIE 
IPAEKVFLAQ KMMIGRCNRA GKPVICATQM LESMIKKPRP TRAEGSDVAN AVLDGADCIM 
LSGETAKGDY PLEAVRMQHL IAREAEAAIY HLQLFEELRR LAPITSDPTE ATAVGAVEAS 
FKCCSGAIIV LTKSGRSAHQ VARYRPRAPI IAVTRNPQTA RQAHLYRGIF PVLCKDPVQE 
AWAEDVDLRV NFAMNVGKAR GFFKKGDVVI VLTGWRPGSG FTNTMRVVPV P

Genular Protein ID: 3254224110

Symbol: A0A804F729_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A804F729

Database IDs:

ARBA 13 AlphaFoldDB 1 Bgee 1 CDD 1 CTD 1 ChEBI 7 DisGeNET 1 EC 1 EMBL 1 Ensembl 2 GO 6 Gene3D 3 GeneTree 1 HGNC 1 InterPro 9 NCBI Taxonomy 1 NCBIfam 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 2 Pfam 4 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 3 UniPathway 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

Sequence Information:

  • Length: 605
  • Mass: 65931
  • Checksum: DC4C65D9618A1816
  • Sequence:
    • MQWSSERGER LLTPGACSSE VPSAVPSRSG GSPGHTVFSS ERSLLVRPRS HPEPKGEHYV 
TGSPTPENQR TSAAMSKPHS EAGTAFIQTQ QLHAAMADTF LEHMCRLDID SPPITARNTG 
IICTIGPASR SVETLKEMIK SGMNVARLNF SHGTHEYHAE TIKNVRTATE SFASDPILYR 
PVAVALDTKG PEIRTGLIKG SGTAEVELKK GATLKITLDN AYMEKCDENI LWLDYKNICK 
VVEVGSKIYV DDGLISLQVK QKGADFLVTE VENGGSLGSK KGVNLPGAAV DLPAVSEKDI 
QDLKFGVEQD VDMVFASFIR KASDVHEVRK VLGEKGKNIK IISKIENHEG VRRFDEILEA 
SDGIMVARGD LGIEIPAEKV FLAQKMMIGR CNRAGKPVIC ATQMLESMIK KPRPTRAEGS 
DVANAVLDGA DCIMLSGETA KGDYPLEAVR MQHLIAREAE AAMFHRKLFE ELVRASSHST 
DLMEAMAMGS VEASYKCLAA ALIVLTESGR SAHQVARYRP RAPIIAVTRN PQTARQAHLY 
RGIFPVLCKD PVQEAWAEDV DLRVNFAMNV GKARGFFKKG DVVIVLTGWR PGSGFTNTMR 
VVPVP

Genular Protein ID: 782644606

Symbol: A0A804F6T5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A804F6T5

Database IDs:

ARBA 13 Bgee 1 CDD 1 CTD 1 ChEBI 7 DisGeNET 1 EC 1 EMBL 3 Ensembl 2 GO 6 Gene3D 3 GeneTree 1 HGNC 1 InterPro 9 NCBI Taxonomy 1 NCBIfam 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 4 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 1 RuleBase 1 SAM 1 SUPFAM 3 UniPathway 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

Sequence Information:

  • Length: 566
  • Mass: 61594
  • Checksum: AFBF0A28554E2C10
  • Sequence:
    • MQWSSERGER LLTPGACSSE VPSAVPSRSG GTSAAMSKPH SEAGTAFIQT QQLHAAMADT 
FLEHMCRLDI DSPPITARNT GIICTIGPAS RSVETLKEMI KSGMNVARLN FSHGTHEYHA 
ETIKNVRTAT ESFASDPILY RPVAVALDTK GPEIRTGLIK GSGTAEVELK KGATLKITLD 
NAYMEKCDEN ILWLDYKNIC KVVEVGSKIY VDDGLISLQV KQKGADFLVT EVENGGSLGS 
KKGVNLPGAA VDLPAVSEKD IQDLKFGVEQ DVDMVFASFI RKASDVHEVR KVLGEKGKNI 
KIISKIENHE GVRRFDEILE ASDGIMVARG DLGIEIPAEK VFLAQKMMIG RCNRAGKPVI 
CATQMLESMI KKPRPTRAEG SDVANAVLDG ADCIMLSGET AKGDYPLEAV RMQHLIAREA 
EAAMFHRKLF EELVRASSHS TDLMEAMAMG SVEASYKCLA AALIVLTESG RSAHQVARYR 
PRAPIIAVTR NPQTARQAHL YRGIFPVLCK DPVQEAWAED VDLRVNFAMN VGKARGFFKK 
GDVVIVLTGW RPGSGFTNTM RVVPVP

Genular Protein ID: 4055232665

Symbol: B4DNK4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DNK4

Database IDs:

ARBA 13 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 6 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 2 GO 5 Gene3D 3 GeneTree 1 HGNC 1 InterPro 9 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 4 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 1 RuleBase 1 SUPFAM 3 UCSC 1 UniPathway 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 457
  • Mass: 49898
  • Checksum: FC7B2566EEDC7096
  • Sequence:
    • MSKPHSEAGT AFIQTQQLHA AMADTFLEHM CRLDIDSPPI TARNTGIICT IGPASRSVEL 
KKGATLKITL DNAYMEKCDE NILWLDYKNI CKVVEVGSKI YVDDGLISLQ VKQKGADFLV 
TEVENGGSLG SKKGVNLPGA AVDLPAVSEK DIQDLKFGVE QDVDMVFASF IRKASDVHEV 
RKVLGEKGKN IKIISKIENH EGVRRFDEIL EASDGIMVAR GDLGIEIPAE KVFLAQKMMI 
GRCNRAGKPV ICATQMLESM IKKPRPTRAE GSDVANAVLD GADCIMLSGE TAKGDYPLEA 
VRMQHLIARE AEAAIYHLQL FEELRRLAPI TSDPTEATAV GAVEASFKCC SGAIIVLTKS 
GRSAHQVARY RPRAPIIAVT RNPQTARQAH LYRGIFPVLC KDPVQEAWAE DVDLRVNFAM 
NVGKARGFFK KGDVVIVLTG WRPGSGFTNT MRVVPVP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.