Details for: PSMA7
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 618.4053
Cell Significance Index: -96.1900 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 406.6733
Cell Significance Index: -103.1500 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 323.3664
Cell Significance Index: -133.2100 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 273.1275
Cell Significance Index: -110.9600 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 272.2809
Cell Significance Index: -128.5500 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 243.8348
Cell Significance Index: -125.4300 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 192.7805
Cell Significance Index: -129.3600 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 118.7388
Cell Significance Index: -113.3700 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 101.2364
Cell Significance Index: -124.8200 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 33.4056
Cell Significance Index: -131.8200 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 32.8867
Cell Significance Index: -101.0100 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 22.7112
Cell Significance Index: -60.8400 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 20.0632
Cell Significance Index: -43.9100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 4.2659
Cell Significance Index: 200.5000 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.6959
Cell Significance Index: 68.3100 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 3.3649
Cell Significance Index: 462.0900 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 3.2692
Cell Significance Index: 37.1400 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 3.2650
Cell Significance Index: 95.8900 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 3.2281
Cell Significance Index: 67.5700 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 3.1143
Cell Significance Index: 200.9200 - Cell Name: granulosa cell (CL0000501)
Fold Change: 3.0865
Cell Significance Index: 81.1600 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 3.0640
Cell Significance Index: 142.8600 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 3.0516
Cell Significance Index: 550.1200 - Cell Name: cell in vitro (CL0001034)
Fold Change: 2.9685
Cell Significance Index: 1621.1800 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 2.8774
Cell Significance Index: 99.9900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.7792
Cell Significance Index: 327.7500 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 2.7693
Cell Significance Index: 340.5100 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 2.4978
Cell Significance Index: 1104.3200 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 2.4746
Cell Significance Index: 175.0200 - Cell Name: odontoblast (CL0000060)
Fold Change: 2.1254
Cell Significance Index: 272.4700 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 2.0935
Cell Significance Index: 109.0500 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 2.0405
Cell Significance Index: 122.5000 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 2.0225
Cell Significance Index: 18.6300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.9923
Cell Significance Index: 54.2300 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.8943
Cell Significance Index: 54.3000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.8677
Cell Significance Index: 139.2000 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.8627
Cell Significance Index: 240.6500 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.7939
Cell Significance Index: 94.1900 - Cell Name: peg cell (CL4033014)
Fold Change: 1.4262
Cell Significance Index: 32.9500 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.3083
Cell Significance Index: 23.1200 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.1930
Cell Significance Index: 12.9700 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.0550
Cell Significance Index: 28.1700 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.9035
Cell Significance Index: 179.3100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.8781
Cell Significance Index: 45.6200 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.6351
Cell Significance Index: 13.7600 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.5320
Cell Significance Index: 90.8400 - Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 0.5225
Cell Significance Index: 4.4900 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4503
Cell Significance Index: 85.6900 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3715
Cell Significance Index: 335.4400 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2723
Cell Significance Index: 26.9400 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.2645
Cell Significance Index: 200.1800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.2529
Cell Significance Index: 50.7400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.1378
Cell Significance Index: 101.0100 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0753
Cell Significance Index: 1.2600 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0690
Cell Significance Index: 24.7400 - Cell Name: kidney cell (CL1000497)
Fold Change: 0.0200
Cell Significance Index: 0.1600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0169
Cell Significance Index: -12.5200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0248
Cell Significance Index: -46.7400 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0350
Cell Significance Index: -21.8800 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0430
Cell Significance Index: -4.3900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0611
Cell Significance Index: -112.6000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0639
Cell Significance Index: -98.4300 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0944
Cell Significance Index: -128.2900 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1407
Cell Significance Index: -89.3700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1532
Cell Significance Index: -86.3900 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.1743
Cell Significance Index: -120.5700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.2122
Cell Significance Index: -96.3300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.2630
Cell Significance Index: -9.2400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2835
Cell Significance Index: -59.7200 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3233
Cell Significance Index: -37.0400 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.3608
Cell Significance Index: -2.1800 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3639
Cell Significance Index: -42.4100 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.3868
Cell Significance Index: -111.3000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.4577
Cell Significance Index: -28.1300 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.5334
Cell Significance Index: -86.7500 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.5433
Cell Significance Index: -13.8800 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.5486
Cell Significance Index: -17.5700 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.7132
Cell Significance Index: -103.6700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.7436
Cell Significance Index: -20.7800 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.8138
Cell Significance Index: -64.4500 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.8609
Cell Significance Index: -98.2700 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.8845
Cell Significance Index: -55.7500 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.9320
Cell Significance Index: -101.3700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -1.1975
Cell Significance Index: -67.2000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.2410
Cell Significance Index: -129.2200 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -1.2719
Cell Significance Index: -97.6100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -1.2981
Cell Significance Index: -58.8400 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -1.5602
Cell Significance Index: -104.9100 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -1.6827
Cell Significance Index: -21.5500 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.6836
Cell Significance Index: -22.9700 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -1.8518
Cell Significance Index: -49.6200 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -1.9896
Cell Significance Index: -53.2200 - Cell Name: Sertoli cell (CL0000216)
Fold Change: -2.0119
Cell Significance Index: -28.2200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -2.0896
Cell Significance Index: -128.1100 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -2.0984
Cell Significance Index: -51.2000 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -2.1859
Cell Significance Index: -37.4600 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -2.2432
Cell Significance Index: -38.6700 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -2.2655
Cell Significance Index: -19.0300 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -2.3402
Cell Significance Index: -68.9300 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -2.3448
Cell Significance Index: -35.1400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 871818572
Symbol: PSA7_HUMAN
Name: Proteasome subunit RC6-1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8764072
Title: Proteasome complex as a potential cellular target of hepatitis B virus X protein.
PubMed ID: 8764072
PubMed ID: 11042152
Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.
PubMed ID: 11042152
DOI: 10.1101/gr.140200
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 11780052
Title: The DNA sequence and comparative analysis of human chromosome 20.
PubMed ID: 11780052
DOI: 10.1038/414865a
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8610016
Title: A role for the proteasome regulator PA28alpha in antigen presentation.
PubMed ID: 8610016
DOI: 10.1038/381166a0
PubMed ID: 10748218
Title: Structural and functional characterization of interaction between hepatitis B virus X protein and the proteasome complex.
PubMed ID: 10748218
PubMed ID: 11389899
Title: Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7.
PubMed ID: 11389899
PubMed ID: 11713272
Title: Involvement of proteasome alpha-subunit PSMA7 in hepatitis C virus internal ribosome entry site-mediated translation.
PubMed ID: 11713272
PubMed ID: 11574696
Title: C-SPACE (cleavage-specific amplification of cDNA ends): a novel method of ribozyme-mediated gene identification.
PubMed ID: 11574696
PubMed ID: 12119296
Title: Proteasome activity is required for androgen receptor transcriptional activity via regulation of androgen receptor nuclear translocation and interaction with coregulators in prostate cancer cells.
PubMed ID: 12119296
PubMed ID: 12181345
Title: Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome.
PubMed ID: 12181345
PubMed ID: 14550573
Title: Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits.
PubMed ID: 14550573
PubMed ID: 15244466
Title: 20S proteasome prevents aggregation of heat-denatured proteins without PA700 regulatory subcomplex like a molecular chaperone.
PubMed ID: 15244466
DOI: 10.1021/bm049957a
PubMed ID: 14759258
PubMed ID: 14998988
Title: The proteasome alpha-subunit XAPC7 interacts specifically with Rab7 and late endosomes.
PubMed ID: 14998988
PubMed ID: 15987638
Title: Parkin interacts with the proteasome subunit alpha4.
PubMed ID: 15987638
PubMed ID: 16251969
Title: A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes.
PubMed ID: 16251969
DOI: 10.1038/nature04106
PubMed ID: 16678104
Title: Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation.
PubMed ID: 16678104
PubMed ID: 17323924
Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.
PubMed ID: 17323924
DOI: 10.1021/bi061994u
PubMed ID: 18202793
Title: The proteasome subunit PSMA7 located on the 20q13 amplicon is overexpressed and associated with liver metastasis in colorectal cancer.
PubMed ID: 18202793
PubMed ID: 19362550
Title: Endothelial monocyte activating polypeptide-II modulates endothelial cell responses by degrading hypoxia-inducible factor-1alpha through interaction with PSMA7, a component of the proteasome.
PubMed ID: 19362550
PubMed ID: 19734229
Title: Negative regulation of MAVS-mediated innate immune response by PSMA7.
PubMed ID: 19734229
PubMed ID: 19442227
Title: PSMA7, a potential biomarker of diseases.
PubMed ID: 19442227
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23495936
Title: Molecular architecture and assembly of the eukaryotic proteasome.
PubMed ID: 23495936
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27176742
Title: Human 20S proteasome activity towards fluorogenic peptides of various chain lengths.
PubMed ID: 27176742
PubMed ID: 26133119
Title: Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core.
PubMed ID: 26133119
DOI: 10.1038/ncomms8573
PubMed ID: 25599644
Title: Crystal structure of the human 20S proteasome in complex with carfilzomib.
PubMed ID: 25599644
PubMed ID: 27428775
PubMed ID: 27342858
Title: Structure of the human 26S proteasome at a resolution of 3.9 Aa.
PubMed ID: 27342858
PubMed ID: 27493187
Title: The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design.
PubMed ID: 27493187
PubMed ID: 34711951
Title: AKIRIN2 controls the nuclear import of proteasomes in vertebrates.
PubMed ID: 34711951
PubMed ID: 23033978
Title: Diagnostic exome sequencing in persons with severe intellectual disability.
PubMed ID: 23033978
Sequence Information:
- Length: 248
- Mass: 27887
- Checksum: 5DD0276A1C2DEF91
- Sequence:
MSYDRAITVF SPDGHLFQVE YAQEAVKKGS TAVGVRGRDI VVLGVEKKSV AKLQDERTVR KICALDDNVC MAFAGLTADA RIVINRARVE CQSHRLTVED PVTVEYITRY IASLKQRYTQ SNGRRPFGIS ALIVGFDFDG TPRLYQTDPS GTYHAWKANA IGRGAKSVRE FLEKNYTDEA IETDDLTIKL VIKALLEVVQ SGGKNIELAV MRRDQSLKIL NPEEIEKYVA EIEKEKEENE KKKQKKAS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.