Details for: PSMA7

Gene ID: 5688

Symbol: PSMA7

Ensembl ID: ENSG00000101182

Description: proteasome 20S subunit alpha 7

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 5.24
    Marker Score: 3,951
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.9
    Marker Score: 38,598
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.64
    Marker Score: 5,608
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.49
    Marker Score: 4,209
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.38
    Marker Score: 3,526
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.37
    Marker Score: 188,527
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.31
    Marker Score: 38,458
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 3.31
    Marker Score: 1,058
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.12
    Marker Score: 4,292
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.1
    Marker Score: 105,487
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.07
    Marker Score: 5,772
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.05
    Marker Score: 7,452
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3
    Marker Score: 23,461
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.98
    Marker Score: 39,298
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.98
    Marker Score: 1,340
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.96
    Marker Score: 3,161
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.94
    Marker Score: 3,363
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.94
    Marker Score: 9,275
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.93
    Marker Score: 3,252
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.93
    Marker Score: 699
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.92
    Marker Score: 39,173
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.9
    Marker Score: 2,903
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.9
    Marker Score: 1,299
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.89
    Marker Score: 100,102
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.86
    Marker Score: 7,264
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.85
    Marker Score: 3,071
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.85
    Marker Score: 7,881
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.84
    Marker Score: 1,668
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.84
    Marker Score: 72,779
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.83
    Marker Score: 2,223
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.83
    Marker Score: 8,246
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.82
    Marker Score: 3,991
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 2.81
    Marker Score: 3,378
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.8
    Marker Score: 2,385
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.79
    Marker Score: 5,438
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.78
    Marker Score: 4,027
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.77
    Marker Score: 5,537
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 2.77
    Marker Score: 1,851
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.75
    Marker Score: 7,718
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.75
    Marker Score: 3,576
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.74
    Marker Score: 1,142
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.73
    Marker Score: 4,350
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.71
    Marker Score: 2,376
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.7
    Marker Score: 23,262
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.7
    Marker Score: 1,226
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 2.69
    Marker Score: 1,164
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.68
    Marker Score: 14,067
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.67
    Marker Score: 1,755
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.66
    Marker Score: 29,961
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.66
    Marker Score: 1,328
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.65
    Marker Score: 16,969
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.65
    Marker Score: 2,379
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.65
    Marker Score: 17,247
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.65
    Marker Score: 11,431
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.65
    Marker Score: 2,972
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.65
    Marker Score: 2,879
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.64
    Marker Score: 139,703
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.64
    Marker Score: 10,809
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.64
    Marker Score: 26,752
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.64
    Marker Score: 4,712
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.64
    Marker Score: 17,186
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 2.63
    Marker Score: 1,405
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.63
    Marker Score: 2,217
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.63
    Marker Score: 12,933
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 2.62
    Marker Score: 693
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.61
    Marker Score: 5,458
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 2.61
    Marker Score: 1,681
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.61
    Marker Score: 1,899
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 2.6
    Marker Score: 684
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.59
    Marker Score: 832
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.59
    Marker Score: 1,880
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.59
    Marker Score: 6,250
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.59
    Marker Score: 5,898
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.58
    Marker Score: 6,752
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.58
    Marker Score: 4,702
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.55
    Marker Score: 10,954
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.55
    Marker Score: 4,447
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.55
    Marker Score: 3,290
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.54
    Marker Score: 1,598
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 2.54
    Marker Score: 2,160
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.54
    Marker Score: 1,449
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 2.54
    Marker Score: 1,311
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.54
    Marker Score: 1,921
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.54
    Marker Score: 4,158
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 2.53
    Marker Score: 1,301
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.53
    Marker Score: 2,965
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.53
    Marker Score: 2,444
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.53
    Marker Score: 1,500
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.53
    Marker Score: 4,189
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.52
    Marker Score: 1,031
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 2.52
    Marker Score: 1,698
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.52
    Marker Score: 18,785
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.52
    Marker Score: 1,982
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.51
    Marker Score: 12,068
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.51
    Marker Score: 4,272
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.5
    Marker Score: 1,289
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.5
    Marker Score: 1,041
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.49
    Marker Score: 1,562
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.49
    Marker Score: 4,000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.49
    Marker Score: 9,593

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The PSMA7 gene is a member of the proteasome family, which is characterized by its ability to degrade proteins through a process called proteolysis. The 20S proteasome, to which PSMA7 belongs, is a complex composed of two 19S regulatory particles and a 20S core particle. The 20S core particle is responsible for the actual proteolysis, with PSMA7 being one of its alpha subunits. The PSMA7 protein is a 23-kDa subunit that plays a crucial role in the degradation of proteins, particularly those involved in cell signaling and transcription. **Pathways and Functions** The PSMA7 gene is involved in various cellular processes, including: 1. **Protein degradation**: PSMA7 participates in the degradation of damaged or unneeded proteins, which is essential for maintaining cellular homeostasis and regulating cell growth and division. 2. **Immune function**: PSMA7 is expressed in immune cells, such as T cells and dendritic cells, where it plays a role in the regulation of immune responses and the presentation of antigens to T cells. 3. **Cell cycle regulation**: PSMA7 is involved in the regulation of the cell cycle, particularly in the G2/M phase, where it helps to degrade proteins that promote cell growth and proliferation. 4. **Stress response**: PSMA7 is activated in response to stress and damage, allowing cells to degrade damaged proteins and restore homeostasis. **Clinical Significance** Dysregulation of the PSMA7 gene has been implicated in various diseases, including: 1. **Cancer**: Overexpression of PSMA7 has been observed in certain types of cancer, such as prostate cancer, where it contributes to tumor progression and metastasis. 2. **Immunodeficiency**: Mutations in the PSMA7 gene have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID), where the lack of functional PSMA7 leads to impaired immune function. 3. **Neurodegenerative diseases**: PSMA7 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it contributes to protein aggregation and neuronal dysfunction. In conclusion, the PSMA7 gene plays a crucial role in protein degradation, immune function, and cell cycle regulation, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the mechanisms by which PSMA7 contributes to disease and to develop therapeutic strategies to target this gene.

Genular Protein ID: 871818572

Symbol: PSA7_HUMAN

Name: Proteasome subunit alpha type-7

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8764072

Title: Proteasome complex as a potential cellular target of hepatitis B virus X protein.

PubMed ID: 8764072

DOI: 10.1128/jvi.70.8.5582-5591.1996

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8610016

Title: A role for the proteasome regulator PA28alpha in antigen presentation.

PubMed ID: 8610016

DOI: 10.1038/381166a0

PubMed ID: 10748218

Title: Structural and functional characterization of interaction between hepatitis B virus X protein and the proteasome complex.

PubMed ID: 10748218

DOI: 10.1074/jbc.m910378199

PubMed ID: 11389899

Title: Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7.

PubMed ID: 11389899

DOI: 10.1016/s0014-5793(01)02499-1

PubMed ID: 11713272

Title: Involvement of proteasome alpha-subunit PSMA7 in hepatitis C virus internal ribosome entry site-mediated translation.

PubMed ID: 11713272

DOI: 10.1128/mcb.21.24.8357-8364.2001

PubMed ID: 11574696

Title: C-SPACE (cleavage-specific amplification of cDNA ends): a novel method of ribozyme-mediated gene identification.

PubMed ID: 11574696

DOI: 10.1093/nar/29.19.e94

PubMed ID: 12119296

Title: Proteasome activity is required for androgen receptor transcriptional activity via regulation of androgen receptor nuclear translocation and interaction with coregulators in prostate cancer cells.

PubMed ID: 12119296

DOI: 10.1074/jbc.m204751200

PubMed ID: 12181345

Title: Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome.

PubMed ID: 12181345

DOI: 10.1091/mbc.e02-03-0122

PubMed ID: 14550573

Title: Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits.

PubMed ID: 14550573

DOI: 10.1016/s0014-5793(03)01025-1

PubMed ID: 15244466

Title: 20S proteasome prevents aggregation of heat-denatured proteins without PA700 regulatory subcomplex like a molecular chaperone.

PubMed ID: 15244466

DOI: 10.1021/bm049957a

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 14998988

Title: The proteasome alpha-subunit XAPC7 interacts specifically with Rab7 and late endosomes.

PubMed ID: 14998988

DOI: 10.1074/jbc.m401022200

PubMed ID: 15987638

Title: Parkin interacts with the proteasome subunit alpha4.

PubMed ID: 15987638

DOI: 10.1016/j.febslet.2005.06.003

PubMed ID: 16251969

Title: A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes.

PubMed ID: 16251969

DOI: 10.1038/nature04106

PubMed ID: 16678104

Title: Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation.

PubMed ID: 16678104

DOI: 10.1016/j.molcel.2006.04.007

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 18202793

Title: The proteasome subunit PSMA7 located on the 20q13 amplicon is overexpressed and associated with liver metastasis in colorectal cancer.

PubMed ID: 18202793

PubMed ID: 19362550

Title: Endothelial monocyte activating polypeptide-II modulates endothelial cell responses by degrading hypoxia-inducible factor-1alpha through interaction with PSMA7, a component of the proteasome.

PubMed ID: 19362550

DOI: 10.1016/j.yexcr.2009.03.021

PubMed ID: 19734229

Title: Negative regulation of MAVS-mediated innate immune response by PSMA7.

PubMed ID: 19734229

DOI: 10.4049/jimmunol.0901646

PubMed ID: 19442227

Title: PSMA7, a potential biomarker of diseases.

PubMed ID: 19442227

DOI: 10.2174/092986609788167824

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27176742

Title: Human 20S proteasome activity towards fluorogenic peptides of various chain lengths.

PubMed ID: 27176742

DOI: 10.1515/hsz-2016-0176

PubMed ID: 26133119

Title: Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core.

PubMed ID: 26133119

DOI: 10.1038/ncomms8573

PubMed ID: 25599644

Title: Crystal structure of the human 20S proteasome in complex with carfilzomib.

PubMed ID: 25599644

DOI: 10.1016/j.str.2014.11.017

PubMed ID: 27428775

Title: An atomic structure of the human 26S proteasome.

PubMed ID: 27428775

DOI: 10.1038/nsmb.3273

PubMed ID: 27342858

Title: Structure of the human 26S proteasome at a resolution of 3.9 Aa.

PubMed ID: 27342858

DOI: 10.1073/pnas.1608050113

PubMed ID: 27493187

Title: The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design.

PubMed ID: 27493187

DOI: 10.1126/science.aaf8993

PubMed ID: 34711951

Title: AKIRIN2 controls the nuclear import of proteasomes in vertebrates.

PubMed ID: 34711951

DOI: 10.1038/s41586-021-04035-8

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

Sequence Information:

  • Length: 248
  • Mass: 27887
  • Checksum: 5DD0276A1C2DEF91
  • Sequence:
  • MSYDRAITVF SPDGHLFQVE YAQEAVKKGS TAVGVRGRDI VVLGVEKKSV AKLQDERTVR 
    KICALDDNVC MAFAGLTADA RIVINRARVE CQSHRLTVED PVTVEYITRY IASLKQRYTQ 
    SNGRRPFGIS ALIVGFDFDG TPRLYQTDPS GTYHAWKANA IGRGAKSVRE FLEKNYTDEA 
    IETDDLTIKL VIKALLEVVQ SGGKNIELAV MRRDQSLKIL NPEEIEKYVA EIEKEKEENE 
    KKKQKKAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.