PSMA7 | ENSG00000101182 | NCBI 5688

Details for: PSMA7

Gene ID: 5688

Symbol: PSMA7

Ensembl ID: ENSG00000101182

Description: proteasome 20S subunit alpha 7

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Abc transporter disorders
(R-HSA-5619084)
Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apoptosis
(R-HSA-109581)
Assembly of the pre-replicative complex
(R-HSA-68867)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-HSA-450408)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cellular response to hypoxia
(R-HSA-1234174)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective cftr causes cystic fibrosis
(R-HSA-5678895)
Degradation of axin
(R-HSA-4641257)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Degradation of dvl
(R-HSA-4641258)
Degradation of gli1 by the proteasome
(R-HSA-5610780)
Degradation of gli2 by the proteasome
(R-HSA-5610783)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of transmembrane transporters
(R-HSA-5619115)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
Downstream tcr signaling
(R-HSA-202424)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Formation of paraxial mesoderm
(R-HSA-9793380)
G1/s dna damage checkpoints
(R-HSA-69615)
G2/m checkpoints
(R-HSA-69481)
Gastrulation
(R-HSA-9758941)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gli3 is processed to gli3r by the proteasome
(R-HSA-5610785)
Hedgehog 'off' state
(R-HSA-5610787)
Hedgehog 'on' state
(R-HSA-5632684)
Hedgehog ligand biogenesis
(R-HSA-5358346)
Hh mutants abrogate ligand secretion
(R-HSA-5387390)
Hh mutants are degraded by erad
(R-HSA-5362768)
Hiv infection
(R-HSA-162906)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of polyamines
(R-HSA-351202)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
M phase
(R-HSA-68886)
Neddylation
(R-HSA-8951664)
Nervous system development
(R-HSA-9675108)
Nik-->noncanonical nf-kb signaling
(R-HSA-5676590)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-HSA-1234176)
Pcp/ce pathway
(R-HSA-4086400)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Proteasome assembly
(R-HSA-9907900)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of activated pak-2p34 by proteasome mediated degradation
(R-HSA-211733)
Regulation of apoptosis
(R-HSA-169911)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Regulation of ornithine decarboxylase (odc)
(R-HSA-350562)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by notch4
(R-HSA-9013694)
Signaling by robo receptors
(R-HSA-376176)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tcr signaling
(R-HSA-202403)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Transport of small molecules
(R-HSA-382551)
Ub-specific processing proteases
(R-HSA-5689880)
Uch proteinases
(R-HSA-5689603)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 618.4053
Cell Significance Index: -96.1900
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 406.6733
Cell Significance Index: -103.1500
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 323.3664
Cell Significance Index: -133.2100
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 273.1275
Cell Significance Index: -110.9600
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 272.2809
Cell Significance Index: -128.5500
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 243.8348
Cell Significance Index: -125.4300
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 192.7805
Cell Significance Index: -129.3600
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 118.7388
Cell Significance Index: -113.3700
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 101.2364
Cell Significance Index: -124.8200
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 33.4056
Cell Significance Index: -131.8200
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 32.8867
Cell Significance Index: -101.0100
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 22.7112
Cell Significance Index: -60.8400
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 20.0632
Cell Significance Index: -43.9100
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 4.2659
Cell Significance Index: 200.5000
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.6959
Cell Significance Index: 68.3100
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 3.3649
Cell Significance Index: 462.0900
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 3.2692
Cell Significance Index: 37.1400
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 3.2650
Cell Significance Index: 95.8900
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 3.2281
Cell Significance Index: 67.5700
Cell Name: early pro-B cell (CL0002046)
Fold Change: 3.1143
Cell Significance Index: 200.9200
Cell Name: granulosa cell (CL0000501)
Fold Change: 3.0865
Cell Significance Index: 81.1600
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 3.0640
Cell Significance Index: 142.8600
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 3.0516
Cell Significance Index: 550.1200
Cell Name: cell in vitro (CL0001034)
Fold Change: 2.9685
Cell Significance Index: 1621.1800
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 2.8774
Cell Significance Index: 99.9900
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.7792
Cell Significance Index: 327.7500
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 2.7693
Cell Significance Index: 340.5100
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 2.4978
Cell Significance Index: 1104.3200
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 2.4746
Cell Significance Index: 175.0200
Cell Name: odontoblast (CL0000060)
Fold Change: 2.1254
Cell Significance Index: 272.4700
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 2.0935
Cell Significance Index: 109.0500
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 2.0405
Cell Significance Index: 122.5000
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 2.0225
Cell Significance Index: 18.6300
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.9923
Cell Significance Index: 54.2300
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.8943
Cell Significance Index: 54.3000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.8677
Cell Significance Index: 139.2000
Cell Name: lactocyte (CL0002325)
Fold Change: 1.8627
Cell Significance Index: 240.6500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.7939
Cell Significance Index: 94.1900
Cell Name: peg cell (CL4033014)
Fold Change: 1.4262
Cell Significance Index: 32.9500
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.3083
Cell Significance Index: 23.1200
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.1930
Cell Significance Index: 12.9700
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.0550
Cell Significance Index: 28.1700
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.9035
Cell Significance Index: 179.3100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.8781
Cell Significance Index: 45.6200
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.6351
Cell Significance Index: 13.7600
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.5320
Cell Significance Index: 90.8400
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 0.5225
Cell Significance Index: 4.4900
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4503
Cell Significance Index: 85.6900
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3715
Cell Significance Index: 335.4400
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2723
Cell Significance Index: 26.9400
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.2645
Cell Significance Index: 200.1800
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.2529
Cell Significance Index: 50.7400
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.1378
Cell Significance Index: 101.0100
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0753
Cell Significance Index: 1.2600
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0690
Cell Significance Index: 24.7400
Cell Name: kidney cell (CL1000497)
Fold Change: 0.0200
Cell Significance Index: 0.1600
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0169
Cell Significance Index: -12.5200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0248
Cell Significance Index: -46.7400
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0350
Cell Significance Index: -21.8800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0430
Cell Significance Index: -4.3900
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0611
Cell Significance Index: -112.6000
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0639
Cell Significance Index: -98.4300
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0944
Cell Significance Index: -128.2900
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1407
Cell Significance Index: -89.3700
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1532
Cell Significance Index: -86.3900
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.1743
Cell Significance Index: -120.5700
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.2122
Cell Significance Index: -96.3300
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.2630
Cell Significance Index: -9.2400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2835
Cell Significance Index: -59.7200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3233
Cell Significance Index: -37.0400
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.3608
Cell Significance Index: -2.1800
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3639
Cell Significance Index: -42.4100
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.3868
Cell Significance Index: -111.3000
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.4577
Cell Significance Index: -28.1300
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.5334
Cell Significance Index: -86.7500
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.5433
Cell Significance Index: -13.8800
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.5486
Cell Significance Index: -17.5700
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.7132
Cell Significance Index: -103.6700
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.7436
Cell Significance Index: -20.7800
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.8138
Cell Significance Index: -64.4500
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.8609
Cell Significance Index: -98.2700
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.8845
Cell Significance Index: -55.7500
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.9320
Cell Significance Index: -101.3700
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -1.1975
Cell Significance Index: -67.2000
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.2410
Cell Significance Index: -129.2200
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -1.2719
Cell Significance Index: -97.6100
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -1.2981
Cell Significance Index: -58.8400
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -1.5602
Cell Significance Index: -104.9100
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -1.6827
Cell Significance Index: -21.5500
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.6836
Cell Significance Index: -22.9700
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -1.8518
Cell Significance Index: -49.6200
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -1.9896
Cell Significance Index: -53.2200
Cell Name: Sertoli cell (CL0000216)
Fold Change: -2.0119
Cell Significance Index: -28.2200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -2.0896
Cell Significance Index: -128.1100
Cell Name: type I muscle cell (CL0002211)
Fold Change: -2.0984
Cell Significance Index: -51.2000
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -2.1859
Cell Significance Index: -37.4600
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -2.2432
Cell Significance Index: -38.6700
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -2.2655
Cell Significance Index: -19.0300
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -2.3402
Cell Significance Index: -68.9300
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -2.3448
Cell Significance Index: -35.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** The PSMA7 gene is a member of the proteasome family, which is characterized by its ability to degrade proteins through a process called proteolysis. The 20S proteasome, to which PSMA7 belongs, is a complex composed of two 19S regulatory particles and a 20S core particle. The 20S core particle is responsible for the actual proteolysis, with PSMA7 being one of its alpha subunits. The PSMA7 protein is a 23-kDa subunit that plays a crucial role in the degradation of proteins, particularly those involved in cell signaling and transcription. **Pathways and Functions** The PSMA7 gene is involved in various cellular processes, including: 1. **Protein degradation**: PSMA7 participates in the degradation of damaged or unneeded proteins, which is essential for maintaining cellular homeostasis and regulating cell growth and division. 2. **Immune function**: PSMA7 is expressed in immune cells, such as T cells and dendritic cells, where it plays a role in the regulation of immune responses and the presentation of antigens to T cells. 3. **Cell cycle regulation**: PSMA7 is involved in the regulation of the cell cycle, particularly in the G2/M phase, where it helps to degrade proteins that promote cell growth and proliferation. 4. **Stress response**: PSMA7 is activated in response to stress and damage, allowing cells to degrade damaged proteins and restore homeostasis. **Clinical Significance** Dysregulation of the PSMA7 gene has been implicated in various diseases, including: 1. **Cancer**: Overexpression of PSMA7 has been observed in certain types of cancer, such as prostate cancer, where it contributes to tumor progression and metastasis. 2. **Immunodeficiency**: Mutations in the PSMA7 gene have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID), where the lack of functional PSMA7 leads to impaired immune function. 3. **Neurodegenerative diseases**: PSMA7 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it contributes to protein aggregation and neuronal dysfunction. In conclusion, the PSMA7 gene plays a crucial role in protein degradation, immune function, and cell cycle regulation, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the mechanisms by which PSMA7 contributes to disease and to develop therapeutic strategies to target this gene.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Proteasome subunit RC6-1

Genular Protein ID: 871818572

Symbol: PSA7_HUMAN

Name: Proteasome subunit RC6-1

UniProtKB Accession Codes:

O14818 B2R515 Q5JXJ2 Q9BR53 Q9H4K5 Q9UEU8

Database IDs:

Citations:

PubMed ID: 8764072

Title: Proteasome complex as a potential cellular target of hepatitis B virus X protein.

PubMed ID: 8764072

DOI: 10.1128/jvi.70.8.5582-5591.1996

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8610016

Title: A role for the proteasome regulator PA28alpha in antigen presentation.

PubMed ID: 8610016

DOI: 10.1038/381166a0

PubMed ID: 10748218

Title: Structural and functional characterization of interaction between hepatitis B virus X protein and the proteasome complex.

PubMed ID: 10748218

DOI: 10.1074/jbc.m910378199

PubMed ID: 11389899

Title: Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7.

PubMed ID: 11389899

DOI: 10.1016/s0014-5793(01)02499-1

PubMed ID: 11713272

Title: Involvement of proteasome alpha-subunit PSMA7 in hepatitis C virus internal ribosome entry site-mediated translation.

PubMed ID: 11713272

DOI: 10.1128/mcb.21.24.8357-8364.2001

PubMed ID: 11574696

Title: C-SPACE (cleavage-specific amplification of cDNA ends): a novel method of ribozyme-mediated gene identification.

PubMed ID: 11574696

DOI: 10.1093/nar/29.19.e94

PubMed ID: 12119296

Title: Proteasome activity is required for androgen receptor transcriptional activity via regulation of androgen receptor nuclear translocation and interaction with coregulators in prostate cancer cells.

PubMed ID: 12119296

DOI: 10.1074/jbc.m204751200

PubMed ID: 12181345

Title: Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome.

PubMed ID: 12181345

DOI: 10.1091/mbc.e02-03-0122

PubMed ID: 14550573

Title: Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits.

PubMed ID: 14550573

DOI: 10.1016/s0014-5793(03)01025-1

PubMed ID: 15244466

Title: 20S proteasome prevents aggregation of heat-denatured proteins without PA700 regulatory subcomplex like a molecular chaperone.

PubMed ID: 15244466

DOI: 10.1021/bm049957a

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 14998988

Title: The proteasome alpha-subunit XAPC7 interacts specifically with Rab7 and late endosomes.

PubMed ID: 14998988

DOI: 10.1074/jbc.m401022200

PubMed ID: 15987638

Title: Parkin interacts with the proteasome subunit alpha4.

PubMed ID: 15987638

DOI: 10.1016/j.febslet.2005.06.003

PubMed ID: 16251969

Title: A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes.

PubMed ID: 16251969

DOI: 10.1038/nature04106

PubMed ID: 16678104

Title: Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation.

PubMed ID: 16678104

DOI: 10.1016/j.molcel.2006.04.007

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 18202793

Title: The proteasome subunit PSMA7 located on the 20q13 amplicon is overexpressed and associated with liver metastasis in colorectal cancer.

PubMed ID: 18202793

PubMed ID: 19362550

Title: Endothelial monocyte activating polypeptide-II modulates endothelial cell responses by degrading hypoxia-inducible factor-1alpha through interaction with PSMA7, a component of the proteasome.

PubMed ID: 19362550

DOI: 10.1016/j.yexcr.2009.03.021

PubMed ID: 19734229

Title: Negative regulation of MAVS-mediated innate immune response by PSMA7.

PubMed ID: 19734229

DOI: 10.4049/jimmunol.0901646

PubMed ID: 19442227

Title: PSMA7, a potential biomarker of diseases.

PubMed ID: 19442227

DOI: 10.2174/092986609788167824

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23495936

Title: Molecular architecture and assembly of the eukaryotic proteasome.

PubMed ID: 23495936

DOI: 10.1146/annurev-biochem-060410-150257

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27176742

Title: Human 20S proteasome activity towards fluorogenic peptides of various chain lengths.

PubMed ID: 27176742

DOI: 10.1515/hsz-2016-0176

PubMed ID: 26133119

Title: Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core.

PubMed ID: 26133119

DOI: 10.1038/ncomms8573

PubMed ID: 25599644

Title: Crystal structure of the human 20S proteasome in complex with carfilzomib.

PubMed ID: 25599644

DOI: 10.1016/j.str.2014.11.017

PubMed ID: 27428775

Title: An atomic structure of the human 26S proteasome.

PubMed ID: 27428775

DOI: 10.1038/nsmb.3273

PubMed ID: 27342858

Title: Structure of the human 26S proteasome at a resolution of 3.9 Aa.

PubMed ID: 27342858

DOI: 10.1073/pnas.1608050113

PubMed ID: 27493187

Title: The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design.

PubMed ID: 27493187

DOI: 10.1126/science.aaf8993

PubMed ID: 34711951

Title: AKIRIN2 controls the nuclear import of proteasomes in vertebrates.

PubMed ID: 34711951

DOI: 10.1038/s41586-021-04035-8

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

Sequence Information:

Length: 248
Mass: 27887
Checksum: 5DD0276A1C2DEF91
Sequence:

MSYDRAITVF SPDGHLFQVE YAQEAVKKGS TAVGVRGRDI VVLGVEKKSV AKLQDERTVR 
KICALDDNVC MAFAGLTADA RIVINRARVE CQSHRLTVED PVTVEYITRY IASLKQRYTQ 
SNGRRPFGIS ALIVGFDFDG TPRLYQTDPS GTYHAWKANA IGRGAKSVRE FLEKNYTDEA 
IETDDLTIKL VIKALLEVVQ SGGKNIELAV MRRDQSLKIL NPEEIEKYVA EIEKEKEENE 
KKKQKKAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PSMA7

Associated with

Cells (max top 100)

Other Information

Proteasome complex as a potential cellular target of hepatitis B virus X protein. PubMed ID: 8764072

Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. PubMed ID: 11042152

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A role for the proteasome regulator PA28alpha in antigen presentation. PubMed ID: 8610016

Structural and functional characterization of interaction between hepatitis B virus X protein and the proteasome complex. PubMed ID: 10748218

Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7. PubMed ID: 11389899

Involvement of proteasome alpha-subunit PSMA7 in hepatitis C virus internal ribosome entry site-mediated translation. PubMed ID: 11713272

C-SPACE (cleavage-specific amplification of cDNA ends): a novel method of ribozyme-mediated gene identification. PubMed ID: 11574696

Proteasome activity is required for androgen receptor transcriptional activity via regulation of androgen receptor nuclear translocation and interaction with coregulators in prostate cancer cells. PubMed ID: 12119296

Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome. PubMed ID: 12181345

Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits. PubMed ID: 14550573

20S proteasome prevents aggregation of heat-denatured proteins without PA700 regulatory subcomplex like a molecular chaperone. PubMed ID: 15244466

An unappreciated role for RNA surveillance. PubMed ID: 14759258

The proteasome alpha-subunit XAPC7 interacts specifically with Rab7 and late endosomes. PubMed ID: 14998988

Parkin interacts with the proteasome subunit alpha4. PubMed ID: 15987638

A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes. PubMed ID: 16251969

Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation. PubMed ID: 16678104

Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. PubMed ID: 17323924

The proteasome subunit PSMA7 located on the 20q13 amplicon is overexpressed and associated with liver metastasis in colorectal cancer. PubMed ID: 18202793

Endothelial monocyte activating polypeptide-II modulates endothelial cell responses by degrading hypoxia-inducible factor-1alpha through interaction with PSMA7, a component of the proteasome. PubMed ID: 19362550

Negative regulation of MAVS-mediated innate immune response by PSMA7. PubMed ID: 19734229

PSMA7, a potential biomarker of diseases. PubMed ID: 19442227

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Molecular architecture and assembly of the eukaryotic proteasome. PubMed ID: 23495936

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Human 20S proteasome activity towards fluorogenic peptides of various chain lengths. PubMed ID: 27176742

Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core. PubMed ID: 26133119

Crystal structure of the human 20S proteasome in complex with carfilzomib. PubMed ID: 25599644

An atomic structure of the human 26S proteasome. PubMed ID: 27428775

Structure of the human 26S proteasome at a resolution of 3.9 Aa. PubMed ID: 27342858

The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. PubMed ID: 27493187

AKIRIN2 controls the nuclear import of proteasomes in vertebrates. PubMed ID: 34711951

Diagnostic exome sequencing in persons with severe intellectual disability. PubMed ID: 23033978