PSMA7 | ENSG00000101182 | NCBI 5688

Details for: PSMA7

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Abc transporter disorders
(R-HSA-5619084)
Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176814)
Activation of nf-kappab in b cells
(R-HSA-1169091)
Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176409)
Apc/c:cdc20 mediated degradation of securin
(R-HSA-174154)
Apc/c:cdh1 mediated degradation of cdc20 and other apc/c:cdh1 targeted proteins in late mitosis/early g1
(R-HSA-174178)
Apc:cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
(R-HSA-179419)
Apoptosis
(R-HSA-109581)
Assembly of the pre-replicative complex
(R-HSA-68867)
Asymmetric localization of pcp proteins
(R-HSA-4608870)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-HSA-450408)
Autodegradation of cdh1 by cdh1:apc/c
(R-HSA-174084)
Autodegradation of the e3 ubiquitin ligase cop1
(R-HSA-349425)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cdc20:phospho-apc/c mediated degradation of cyclin a
(R-HSA-174184)
Cdk-mediated phosphorylation and removal of cdc6
(R-HSA-69017)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cellular response to hypoxia
(R-HSA-1234174)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Cross-presentation of soluble exogenous antigens (endosomes)
(R-HSA-1236978)
Cyclin a:cdk2-associated events at s phase entry
(R-HSA-69656)
Cyclin e associated events during g1/s transition
(R-HSA-69202)
Cytokine signaling in immune system
(R-HSA-1280215)
Dectin-1 mediated noncanonical nf-kb signaling
(R-HSA-5607761)
Defective cftr causes cystic fibrosis
(R-HSA-5678895)
Degradation of axin
(R-HSA-4641257)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Degradation of dvl
(R-HSA-4641258)
Degradation of gli1 by the proteasome
(R-HSA-5610780)
Degradation of gli2 by the proteasome
(R-HSA-5610783)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of transmembrane transporters
(R-HSA-5619115)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
Downstream tcr signaling
(R-HSA-202424)
Er-phagosome pathway
(R-HSA-1236974)
Fbxl7 down-regulates aurka during mitotic entry and in early mitosis
(R-HSA-8854050)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Formation of paraxial mesoderm
(R-HSA-9793380)
G1/s dna damage checkpoints
(R-HSA-69615)
G1/s transition
(R-HSA-69206)
G2/m checkpoints
(R-HSA-69481)
G2/m transition
(R-HSA-69275)
Gastrulation
(R-HSA-9758941)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gli3 is processed to gli3r by the proteasome
(R-HSA-5610785)
Gsk3b and btrc:cul1-mediated-degradation of nfe2l2
(R-HSA-9762114)
Hedgehog 'off' state
(R-HSA-5610787)
Hedgehog 'on' state
(R-HSA-5632684)
Hedgehog ligand biogenesis
(R-HSA-5358346)
Hh mutants abrogate ligand secretion
(R-HSA-5387390)
Hh mutants are degraded by erad
(R-HSA-5362768)
Hiv infection
(R-HSA-162906)
Host interactions of hiv factors
(R-HSA-162909)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-1 signaling
(R-HSA-9020702)
Intracellular signaling by second messengers
(R-HSA-9006925)
Keap1-nfe2l2 pathway
(R-HSA-9755511)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of polyamines
(R-HSA-351202)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic anaphase
(R-HSA-68882)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
M phase
(R-HSA-68886)
Neddylation
(R-HSA-8951664)
Negative regulation of notch4 signaling
(R-HSA-9604323)
Nervous system development
(R-HSA-9675108)
Nik-->noncanonical nf-kb signaling
(R-HSA-5676590)
Nuclear events mediated by nfe2l2
(R-HSA-9759194)
Orc1 removal from chromatin
(R-HSA-68949)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-HSA-1234176)
P53-dependent g1 dna damage response
(R-HSA-69563)
P53-dependent g1/s dna damage checkpoint
(R-HSA-69580)
P53-independent dna damage response
(R-HSA-69610)
P53-independent g1/s dna damage checkpoint
(R-HSA-69613)
Pcp/ce pathway
(R-HSA-4086400)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Proteasome assembly
(R-HSA-9907900)
Pten regulation
(R-HSA-6807070)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of activated pak-2p34 by proteasome mediated degradation
(R-HSA-211733)
Regulation of apc/c activators between g1/s and early anaphase
(R-HSA-176408)
Regulation of apoptosis
(R-HSA-169911)
Regulation of expression of slits and robos
(R-HSA-9010553)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Regulation of ornithine decarboxylase (odc)
(R-HSA-350562)
Regulation of pten stability and activity
(R-HSA-8948751)
Regulation of ras by gaps
(R-HSA-5658442)
Regulation of runx2 expression and activity
(R-HSA-8939902)
Regulation of runx3 expression and activity
(R-HSA-8941858)
Rna polymerase ii transcription
(R-HSA-73857)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-HSA-8939236)
Scf(skp2)-mediated degradation of p27/p21
(R-HSA-187577)
Scf-beta-trcp mediated degradation of emi1
(R-HSA-174113)
Separation of sister chromatids
(R-HSA-2467813)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by notch4
(R-HSA-9013694)
Signaling by robo receptors
(R-HSA-376176)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Somitogenesis
(R-HSA-9824272)
S phase
(R-HSA-69242)
Stabilization of p53
(R-HSA-69541)
Switching of origins to a post-replicative state
(R-HSA-69052)
Synthesis of dna
(R-HSA-69239)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tcr signaling
(R-HSA-202403)
The role of gtse1 in g2/m progression after g2 checkpoint
(R-HSA-8852276)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by runx2
(R-HSA-8878166)
Transcriptional regulation by runx3
(R-HSA-8878159)
Transport of small molecules
(R-HSA-382551)
Ub-specific processing proteases
(R-HSA-5689880)
Ubiquitin-dependent degradation of cyclin d
(R-HSA-75815)
Ubiquitin mediated degradation of phosphorylated cdc25a
(R-HSA-69601)
Uch proteinases
(R-HSA-5689603)
Vif-mediated degradation of apobec3g
(R-HSA-180585)
Viral infection pathways
(R-HSA-9824446)
Vpu mediated degradation of cd4
(R-HSA-180534)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Extracellular exosome
(GO:0070062)
Identical protein binding
(GO:0042802)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Proteasome complex
(GO:0000502)
Proteasome core complex
(GO:0005839)
Proteasome core complex, alpha-subunit complex
(GO:0019773)
Protein binding
(GO:0005515)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

granulocyte monocyte progenitor cell CL0000557

CSI 108.51

rCSI 93.96%

PRS 4.74
common myeloid progenitor CL0000049

CSI 99.48

rCSI 80.43%

PRS 4.19
megakaryocyte-erythroid progenitor cell CL0000050

CSI 93.17

rCSI 84.14%

PRS 3.75
hematopoietic stem cell CL0000037

CSI 93.05

rCSI 61.85%

PRS 5.08
elicited macrophage CL0000861

CSI 92.12

rCSI 84.58%

PRS 4.88
fallopian tube secretory epithelial cell CL4030006

CSI 91.04

rCSI 87.64%

PRS 4.4
keratinocyte CL0000312

CSI 76.82

rCSI 64.4%

PRS 5.12
ciliated epithelial cell CL0000067

CSI 76.41

rCSI 67.19%

PRS 3.07
stem cell CL0000034

CSI 75.14

rCSI 72.45%

PRS 2.18
early lymphoid progenitor CL0000936

CSI 71.22

rCSI 62.55%

PRS 4.77
fraction A pre-pro B cell CL0002045

CSI 67.89

rCSI 77.71%

PRS 8.87
plasmablast CL0000980

CSI 67.37

rCSI 53%

PRS 5.08
extravillous trophoblast CL0008036

CSI 64.17

rCSI 79.39%

PRS 3.73
M cell of gut CL0000682

CSI 62.44

rCSI 66.35%

PRS 7.62
intestinal epithelial cell CL0002563

CSI 62.15

rCSI 64.96%

PRS 4.53
transit amplifying cell of colon CL0009011

CSI 61.3

rCSI 72%

PRS 5.16
CD14-low, CD16-positive monocyte CL0002396

CSI 60.8

rCSI 46.84%

PRS 3.85
common dendritic progenitor CL0001029

CSI 60.59

rCSI 76.04%

PRS 5.41
peripheral nervous system neuron CL2000032

CSI 59.68

rCSI 81.31%

PRS 3.85
myeloid leukocyte CL0000766

CSI 58.33

rCSI 53.82%

PRS 4.31
multi-ciliated epithelial cell CL0005012

CSI 56.76

rCSI 56.65%

PRS 3.62
colon epithelial cell CL0011108

CSI 56.7

rCSI 59.39%

PRS 3.97
promyelocyte CL0000836

CSI 56.68

rCSI 81.75%

PRS 5.93
placental villous trophoblast CL2000060

CSI 51.48

rCSI 79.54%

PRS 3.99
neural crest cell CL0011012

CSI 49.9

rCSI 39.44%

PRS 2.94
pro-B cell CL0000826

CSI 49.75

rCSI 41.2%

PRS 4.26
promonocyte CL0000559

CSI 48.73

rCSI 83.49%

PRS 5.7
intestine goblet cell CL0019031

CSI 47.2

rCSI 41.89%

PRS 4.27
epithelial cell of lung CL0000082

CSI 46.73

rCSI 38.74%

PRS 4
conventional dendritic cell CL0000990

CSI 45.99

rCSI 38.39%

PRS 13.81
enterocyte CL0000584

CSI 45.07

rCSI 72.67%

PRS 6.93
enteric smooth muscle cell CL0002504

CSI 44.94

rCSI 64.14%

PRS 4.85
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 44.08

rCSI 29.7%

PRS 5.18
pancreatic D cell CL0000173

CSI 44.07

rCSI 43.34%

PRS 4.65
common lymphoid progenitor CL0000051

CSI 43.23

rCSI 57.76%

PRS 8.18
mesodermal cell CL0000222

CSI 42.7

rCSI 51.25%

PRS 4.26
plasmacytoid dendritic cell, human CL0001058

CSI 42.54

rCSI 29.7%

PRS 4.5
pancreatic ductal cell CL0002079

CSI 41.42

rCSI 80.55%

PRS 4.35
Hofbauer cell CL3000001

CSI 41.19

rCSI 77.76%

PRS 5.33
alveolar macrophage CL0000583

CSI 40.95

rCSI 67.44%

PRS 4.95
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 40.29

rCSI 80.32%

PRS 7.35
enteroendocrine cell CL0000164

CSI 39.04

rCSI 53.35%

PRS 4.71
double-positive, alpha-beta thymocyte CL0000809

CSI 39.01

rCSI 39.75%

PRS 6.19
CD1c-positive myeloid dendritic cell CL0002399

CSI 36.46

rCSI 44.03%

PRS 4.96
alternatively activated macrophage CL0000890

CSI 36.11

rCSI 45.4%

PRS 6.56
epithelial cell CL0000066

CSI 35.18

rCSI 54.06%

PRS 6.15
double negative thymocyte CL0002489

CSI 34.77

rCSI 24.17%

PRS 5.01
kidney epithelial cell CL0002518

CSI 33.72

rCSI 64.36%

PRS 10.47
mucous neck cell CL0000651

CSI 31.78

rCSI 45.8%

PRS 6.91
perivascular cell CL4033054

CSI 31.03

rCSI 42.42%

PRS 4.83
luminal epithelial cell of mammary gland CL0002326

CSI 30.68

rCSI 55.74%

PRS 6.52
muscle cell CL0000187

CSI 30.32

rCSI 62.26%

PRS 10.35
mature T cell CL0002419

CSI 30.25

rCSI 23.53%

PRS 6.15
dendritic cell CL0000451

CSI 30.16

rCSI 37.16%

PRS 14.3
T-helper 17 cell CL0000899

CSI 29.52

rCSI 23.44%

PRS 7.6
CD14-positive, CD16-positive monocyte CL0002397

CSI 29.38

rCSI 38.49%

PRS 5.97
melanocyte CL0000148

CSI 29.24

rCSI 21.65%

PRS 4
microcirculation associated smooth muscle cell CL0008035

CSI 28.96

rCSI 83.83%

PRS 4.83
pancreatic acinar cell CL0002064

CSI 28.92

rCSI 38.44%

PRS 4.66
lung ciliated cell CL1000271

CSI 28.77

rCSI 33.27%

PRS 3.09
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 28.32

rCSI 48.45%

PRS 9.38
classical monocyte CL0000860

CSI 28.26

rCSI 41.89%

PRS 43.56
fibroblast of lung CL0002553

CSI 27.96

rCSI 26.02%

PRS 4.26
pulmonary ionocyte CL0017000

CSI 27.43

rCSI 33.4%

PRS 5.39
foveolar cell of stomach CL0002179

CSI 26.93

rCSI 57.33%

PRS 6.92
bronchus fibroblast of lung CL2000093

CSI 26.78

rCSI 21.76%

PRS 4.49
respiratory hillock cell CL4030023

CSI 26.59

rCSI 47.42%

PRS 7.41
transit amplifying cell CL0009010

CSI 26.51

rCSI 40.54%

PRS 6.97
respiratory suprabasal cell CL4033048

CSI 26.36

rCSI 33.81%

PRS 4.92
secretory cell CL0000151

CSI 26.16

rCSI 27.3%

PRS 4.36
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 25.78

rCSI 29.78%

PRS 3.86
neuroblast (sensu Vertebrata) CL0000031

CSI 25.52

rCSI 32.75%

PRS 4.22
large pre-B-II cell CL0000957

CSI 25.42

rCSI 72.58%

PRS 7.57
progenitor cell CL0011026

CSI 25.42

rCSI 54.06%

PRS 8.21
dendritic cell, human CL0001056

CSI 25.28

rCSI 38.83%

PRS 4.95
forebrain radial glial cell CL0013000

CSI 25.23

rCSI 80.95%

PRS 6.41
mammary gland epithelial cell CL0002327

CSI 25.21

rCSI 88.44%

PRS 7.75
stromal cell of ovary CL0002132

CSI 25.2

rCSI 69.24%

PRS 7.13
tracheal goblet cell CL1000329

CSI 24.58

rCSI 53.66%

PRS 8.74
skin fibroblast CL0002620

CSI 24.49

rCSI 21.11%

PRS 7.07
group 3 innate lymphoid cell CL0001071

CSI 23.88

rCSI 17.95%

PRS 4.39
intestinal crypt stem cell of small intestine CL0009017

CSI 23.14

rCSI 62.37%

PRS 5.55
acinar cell CL0000622

CSI 23.02

rCSI 33.76%

PRS 5.6
goblet cell CL0000160

CSI 22.17

rCSI 20.95%

PRS 4.45
intermediate monocyte CL0002393

CSI 22.14

rCSI 33.41%

PRS 4.19
nasal mucosa goblet cell CL0002480

CSI 21.99

rCSI 25.51%

PRS 6.39
non-classical monocyte CL0000875

CSI 21.57

rCSI 34.58%

PRS 14.03
glandular epithelial cell CL0000150

CSI 20.51

rCSI 54%

PRS 8.33
colon goblet cell CL0009039

CSI 20.44

rCSI 48.6%

PRS 6.49
intrahepatic cholangiocyte CL0002538

CSI 20.32

rCSI 48.76%

PRS 8.11
deuterosomal cell CL4033044

CSI 20.1

rCSI 67.94%

PRS 7.35
conjunctival epithelial cell CL1000432

CSI 19.93

rCSI 30.45%

PRS 4.25
Langerhans cell CL0000453

CSI 19.79

rCSI 30.22%

PRS 7.49
alveolar adventitial fibroblast CL4028006

CSI 19.77

rCSI 31.23%

PRS 4.28
ionocyte CL0005006

CSI 19.74

rCSI 21.15%

PRS 3.93
endothelial cell of artery CL1000413

CSI 19.57

rCSI 28.67%

PRS 25.79
lung macrophage CL1001603

CSI 19.47

rCSI 43.5%

PRS 4.82
type B pancreatic cell CL0000169

CSI 19.41

rCSI 42.98%

PRS 3.99
colonocyte CL1000347

CSI 19.39

rCSI 27.79%

PRS 5.96
basal-myoepithelial cell of mammary gland CL0002324

CSI 19.35

rCSI 36.59%

PRS 9.62

cerebral cortex neuron CL0010012

CSI -15.2

rCSI -62.1%

PRS 5.3%
renal interstitial pericyte CL1001318

CSI -14.7

rCSI -40.5%

PRS 4.9%
sncg GABAergic cortical interneuron CL4023015

CSI -13.6

rCSI -21.8%

PRS 3.0%
airway submucosal gland duct basal cell CL4033024

CSI -13.0

rCSI -82.8%

PRS 20.3%
kidney interstitial alternatively activated macrophage CL1000695

CSI -10.7

rCSI -27.8%

PRS 5.1%
astrocyte of the cerebral cortex CL0002605

CSI -10.6

rCSI -23.7%

PRS 2.7%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI -7.9

rCSI -24.7%

PRS 3.0%
vascular leptomeningeal cell CL4023051

CSI -7.3

rCSI -12.8%

PRS 3.3%
alpha-beta T cell CL0000789

CSI -6.8

rCSI -8.0%

PRS 6.9%
hepatic stellate cell CL0000632

CSI -6.5

rCSI -24.3%

PRS 3.7%
lamp5 GABAergic cortical interneuron CL4023011

CSI -6.3

rCSI -10.6%

PRS 2.6%
neural cell CL0002319

CSI -6.3

rCSI -23.7%

PRS 9.1%
endocardial cell CL0002350

CSI -6.1

rCSI -29.3%

PRS 7.2%
platelet CL0000233

CSI -6.1

rCSI -25.4%

PRS 12.8%
effector CD4-positive, alpha-beta T cell CL0001044

CSI -6.0

rCSI -17.2%

PRS 6.2%
microglial cell CL0000129

CSI -5.9

rCSI -23.9%

PRS 18.8%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI -5.9

rCSI -34.9%

PRS 2.9%
inhibitory interneuron CL0000498

CSI -5.8

rCSI -13.5%

PRS 3.9%
regular ventricular cardiac myocyte CL0002131

CSI -4.9

rCSI -30.7%

PRS 3.5%
brush cell CL0002204

CSI -4.3

rCSI -8.6%

PRS 12.5%
L6b glutamatergic cortical neuron CL4023038

CSI -3.9

rCSI -12.3%

PRS 2.8%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI -3.9

rCSI -13.9%

PRS 2.3%
immature innate lymphoid cell CL0001082

CSI -3.6

rCSI -100.0%

PRS 62.6%
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI -3.5

rCSI -3.2%

PRS 6.7%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI -3.4

rCSI -8.3%

PRS 2.6%
lung resident memory CD4-positive, alpha-beta T cell CL4033038

CSI -2.8

rCSI -27.5%

PRS 46.0%
pvalb GABAergic cortical interneuron CL4023018

CSI -2.7

rCSI -3.4%

PRS 2.4%
retinal bipolar neuron CL0000748

CSI -2.6

rCSI -5.0%

PRS 3.3%
H1 horizontal cell CL0004217

CSI -2.6

rCSI -10.2%

PRS 9.8%
endothelial cell of periportal hepatic sinusoid CL0019021

CSI -2.5

rCSI -11.4%

PRS 16.1%
exhausted T cell CL0011025

CSI -2.3

rCSI -38.1%

PRS 22.1%
group 3 innate lymphoid cell, human CL0001078

CSI -2.2

rCSI -46.1%

PRS 66.2%
IgA plasma cell CL0000987

CSI -2.1

rCSI -2.2%

PRS 8.1%
near-projecting glutamatergic cortical neuron CL4023012

CSI -2.0

rCSI -7.4%

PRS 2.8%
squamous epithelial cell CL0000076

CSI -1.8

rCSI -4.3%

PRS 5.7%
decidual natural killer cell, human CL0002343

CSI -1.7

rCSI -17.2%

PRS 38.7%
naive T cell CL0000898

CSI -1.7

rCSI -1.2%

PRS 6.2%
epicardial adipocyte CL1000309

CSI -1.2

rCSI -3.9%

PRS 6.8%
mast cell CL0000097

CSI -1.2

rCSI -2.5%

PRS 25.3%
Schwann cell CL0002573

CSI -1.1

rCSI -3.2%

PRS 5.8%
cardiac endothelial cell CL0010008

CSI -1.0

rCSI -4.0%

PRS 4.8%
stratified epithelial cell CL0000079

CSI -0.4

rCSI -2.5%

PRS 21.7%
ON midget ganglion cell CL4033046

CSI -0.3

rCSI -5.8%

PRS 4.4%
Bergmann glial cell CL0000644

CSI -0.1

rCSI -0.1%

PRS 4.7%
GABAergic amacrine cell CL4030027

CSI -0.1

rCSI -0.2%

PRS 5.3%
parietal epithelial cell CL1000452

CSI 0.1

rCSI 0.2%

PRS 4.4%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 0.1

rCSI 0.1%

PRS 2.5%
OFF midget ganglion cell CL4033047

CSI 0.2

rCSI 3.7%

PRS 4.8%
eye photoreceptor cell CL0000287

CSI 0.2

rCSI 2.1%

PRS 15.1%
smooth muscle cell of the pulmonary artery CL0002591

CSI 0.2

rCSI 1.5%

PRS 24.6%
sst GABAergic cortical interneuron CL4023017

CSI 0.3

rCSI 0.4%

PRS 2.7%
tissue-resident macrophage CL0000864

CSI 0.4

rCSI 1.9%

PRS 12.0%
cytotoxic T cell CL0000910

CSI 0.4

rCSI 2.4%

PRS 6.7%
lung resident memory CD8-positive, alpha-beta T cell CL4033039

CSI 0.4

rCSI 1.2%

PRS 15.3%
basal cell of epidermis CL0002187

CSI 0.5

rCSI 0.8%

PRS 5.8%
double negative T regulatory cell CL0011024

CSI 0.6

rCSI 11.0%

PRS 36.2%
kidney loop of Henle epithelial cell CL1000909

CSI 0.7

rCSI 13.8%

PRS 37.0%
skeletal muscle satellite stem cell CL0008011

CSI 0.9

rCSI 3.8%

PRS 17.3%
follicular B cell CL0000843

CSI 0.9

rCSI 3.2%

PRS 21.8%
cerebellar granule cell CL0001031

CSI 0.9

rCSI 1.3%

PRS 4.3%
forebrain neuroblast CL1000042

CSI 0.9

rCSI 9.7%

PRS 54.2%
kidney interstitial cell CL1000500

CSI 0.9

rCSI 14.6%

PRS 43.2%
osteoblast CL0000062

CSI 1.0

rCSI 24.0%

PRS 37.8%
cell of skeletal muscle CL0000188

CSI 1.1

rCSI 11.5%

PRS 29.5%
cord blood hematopoietic stem cell CL2000095

CSI 1.1

rCSI 20.9%

PRS 35.5%
Merkel cell CL0000242

CSI 1.2

rCSI 28.2%

PRS 31.5%
B-1 B cell CL0000819

CSI 1.3

rCSI 34.2%

PRS 25.2%
slow muscle cell CL0000189

CSI 1.4

rCSI 18.0%

PRS 39.9%
endothelial cell of venule CL1000414

CSI 1.4

rCSI 12.2%

PRS 26.6%
parietal cell CL0000162

CSI 1.4

rCSI 11.9%

PRS 29.3%
kidney connecting tubule epithelial cell CL1000768

CSI 1.4

rCSI 3.5%

PRS 3.4%
mesenchymal lymphangioblast CL0005021

CSI 1.4

rCSI 37.4%

PRS 23.9%
cone retinal bipolar cell CL0000752

CSI 1.5

rCSI 18.9%

PRS 26.1%
macroglial cell CL0000126

CSI 1.5

rCSI 3.8%

PRS 7.6%
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 1.5

rCSI 2.2%

PRS 4.1%
uterine smooth muscle cell CL0002601

CSI 1.6

rCSI 10.2%

PRS 32.7%
VIP GABAergic cortical interneuron CL4023016

CSI 1.6

rCSI 1.9%

PRS 2.6%
pulmonary alveolar type 1 cell CL0002062

CSI 1.7

rCSI 9.9%

PRS 6.5%
renal intercalated cell CL0005010

CSI 1.7

rCSI 15.4%

PRS 37.9%
epithelial cell of urethra CL1000296

CSI 1.8

rCSI 44.9%

PRS 15.2%
amacrine cell CL0000561

CSI 1.8

rCSI 5.2%

PRS 3.7%
enterocyte of epithelium of large intestine CL0002071

CSI 1.8

rCSI 9.4%

PRS 8.7%
cholangiocyte CL1000488

CSI 1.9

rCSI 11.3%

PRS 8.8%
lung pericyte CL0009089

CSI 1.9

rCSI 5.1%

PRS 5.1%
choroid plexus epithelial cell CL0000706

CSI 1.9

rCSI 3.2%

PRS 3.4%
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 2.0

rCSI 6.1%

PRS 8.7%
follicular dendritic cell CL0000442

CSI 2.1

rCSI 34.1%

PRS 28.4%
activated CD4-positive, alpha-beta T cell, human CL0001043

CSI 2.2

rCSI 5.2%

PRS 30.3%
innate lymphoid cell CL0001065

CSI 2.2

rCSI 4.6%

PRS 7.0%
small intestine goblet cell CL1000495

CSI 2.4

rCSI 5.2%

PRS 5.9%
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 2.5

rCSI 2.4%

PRS 6.9%
endothelial cell of vascular tree CL0002139

CSI 2.5

rCSI 13.5%

PRS 10.8%
kidney distal convoluted tubule epithelial cell CL1000849

CSI 2.5

rCSI 26.5%

PRS 7.3%
cerebral cortex pyramidal neuron CL4023111

CSI 2.5

rCSI 15.7%

PRS 16.2%
chondrocyte CL0000138

CSI 2.6

rCSI 4.1%

PRS 3.9%
centrilobular region hepatocyte CL0019029

CSI 2.6

rCSI 6.7%

PRS 7.6%
pulmonary capillary endothelial cell CL4028001

CSI 2.6

rCSI 5.0%

PRS 6.8%
blood vessel smooth muscle cell CL0019018

CSI 2.7

rCSI 21.6%

PRS 4.5%
CD8-positive, alpha-beta memory T cell CL0000909

CSI 2.7

rCSI 2.8%

PRS 13.8%
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 2.8

rCSI 3.4%

PRS 7.5%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [PSMA7](/details-gene/5688), or Proteasome 20S Subunit Alpha 7, is a protein-coding gene located on chromosome 20q13.33. It encodes a core structural component of the 20S proteasome complex, the catalytic core of the ubiquitin-proteasome system. This system is the primary mechanism for regulated degradation of intracellular proteins, making [PSMA7](/details-gene/5688) a fundamental player in cellular homeostasis, protein quality control, and the cell cycle. **Overall**, expression data indicates that [PSMA7](/details-gene/5688) is most significant in highly proliferative and metabolically active cell populations, particularly hematopoietic progenitors such as `[granulocyte monocyte progenitor cell](/details-cell/CL0000557)s` and `[common myeloid progenitor](/details-cell/CL0000049)s`, as well as various epithelial cells. Its broad involvement in pathways from cell cycle regulation to antigen presentation underscores its essential and ubiquitous cellular function. ## Cellular Roles and Expression Landscape The expression profile of [PSMA7](/details-gene/5688) highlights its critical role in cells with high rates of protein turnover, proliferation, and differentiation. **Overall**, the gene shows the highest significance in hematopoietic stem and progenitor populations, including `[granulocyte monocyte progenitor cell](/details-cell/CL0000557)` (CSI: 108.51), `[common myeloid progenitor](/details-cell/CL0000049)` (CSI: 99.48), `[megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050)` (CSI: 93.17), and `[hematopoietic stem cell](/details-cell/CL0000037)` (CSI: 93.05). This is consistent with the essential function of the proteasome in regulating the cell cycle and clearing proteins to facilitate lineage commitment and development [Link](https://doi.org/10.1101/gr.140200). High significance is also noted in other active cell types such as `[elicited macrophage](/details-cell/CL0000861)s`, `[fallopian tube secretory epithelial cell](/details-cell/CL4030006)s`, and `[keratinocyte](/details-cell/CL0000312)s`, suggesting a vital role in immune response, secretion, and tissue maintenance. Conversely, [PSMA7](/details-gene/5688) shows markedly low significance in terminally differentiated, post-mitotic cell types. The most prominent anti-markers are `[neural cell](/details-cell/CL0002319)s`, including `[cerebral cortex neuron](/details-cell/CL0010012)` (CSI: -15.24) and various GABAergic interneurons. Low significance is also observed in mature lymphocyte populations like `[alpha-beta T cell](/details-cell/CL0000789)s`. This expression pattern suggests that while the proteasome is a housekeeping complex, the reliance on this specific subunit or the overall proteasomal activity it supports is most pronounced in dividing and developing cells, and potentially less central in quiescent, long-lived cells like neurons. ## Pathways and Molecular Function As a core component of the `[proteasome core complex, alpha-subunit complex](/details-go/GO:0019773)`, the primary function of [PSMA7](/details-gene/5688) is its involvement in the `[proteasome-mediated ubiquitin-dependent protein catabolic process](/details-go/GO:0043161)`. Its functional annotations reflect a vast and central role in cellular biology. The extensive list of associated Reactome pathways can be categorized into several key themes: * **Cell Cycle Control:** [PSMA7](/details-gene/5688) is integral to pathways that govern cell cycle progression, such as `[Cell cycle, mitotic](/details-reactome/R-HSA-69278)`, `[Apc/c-mediated degradation of cell cycle proteins](/details-reactome/R-HSA-174143)`, and `[G1/s dna damage checkpoints](/details-reactome/R-HSA-69615)`. This role in degrading cyclins and other regulatory proteins is crucial for orderly transitions between cell cycle phases and is consistent with its high expression in progenitor cells. * **Immune System Regulation:** The proteasome is essential for generating peptides for MHC class I presentation. Accordingly, [PSMA7](/details-gene/5688) is a key component of `[Antigen processing: ubiquitination & proteasome degradation](/details-reactome/R-HSA-983168)` and `[Class i mhc mediated antigen processing & presentation](/details-reactome/R-HSA-983169)`. It also participates in immune signaling cascades like `[Tcr signaling](/details-reactome/R-HSA-202403)` and `[Activation of nf-kappab in b cells](/details-reactome/R-HSA-1169091)`. * **Signal Transduction and Development:** [PSMA7](/details-gene/5688) is involved in degrading key signaling molecules in major developmental pathways, including `[Signaling by wnt](/details-reactome/R-HSA-195721)`, `[Signaling by hedgehog](/details-reactome/R-HSA-5358351)`, and `[Signaling by notch](/details-reactome/R-HSA-157118)`. This underscores its importance in embryogenesis and tissue patterning. * **Pathogen Interaction:** Research has implicated [PSMA7](/details-gene/5688) in the life cycles of several viruses. It has been shown to interact with proteins from Hepatitis B Virus [Link](https://doi.org/10.1128/jvi.70.8.5582-5591.1996), Hepatitis C Virus [Link](https://doi.org/10.1128/mcb.21.24.8357-8364.2001), and HIV-1 [Link](https://doi.org/10.1016/s0014-5793(03)01025-1), suggesting that these pathogens may co-opt the host proteasome for their replication or to degrade host defense factors. ## Research Directions The available data highlights the fundamental role of [PSMA7](/details-gene/5688) in protein degradation, particularly in highly proliferative cells. Future research should focus on the specific dependencies and regulatory mechanisms that govern its function in different cellular contexts. **Testable Hypotheses:** 1. Given its high significance in hematopoietic progenitors and low significance in mature `[alpha-beta T cell](/details-cell/CL0000789)s`, the expression and activity of the [PSMA7](/details-gene/5688)-containing proteasome are dynamically regulated during lymphocyte differentiation. Downregulation of [PSMA7](/details-gene/5688) may be a prerequisite for T cell entry into a quiescent state, and its aberrant sustained expression could contribute to lymphoproliferative disorders. 2. The stark difference in [PSMA7](/details-gene/5688) significance between progenitor cells and terminally differentiated `[neural cell](/details-cell/CL0002319)s` suggests that post-mitotic neurons may rely more heavily on alternative protein clearance mechanisms, such as autophagy, for homeostasis. The [PSMA7](/details-gene/5688)-dependent proteasome may be primarily reserved for processes like synaptic plasticity rather than bulk protein turnover in these cells. **Proposed Experimental Approach:** To test the first hypothesis regarding T cell differentiation, one could employ an *in vitro* differentiation model. `[Hematopoietic stem cell](/details-cell/CL0000037)s` (CD34+) could be isolated from human cord blood and cultured under conditions that promote differentiation towards the T cell lineage. At various stages, [PSMA7](/details-gene/5688) expression would be knocked down using lentiviral-delivered shRNA. The impact on differentiation efficiency and cell state could be assessed by multi-parameter flow cytometry (monitoring markers like CD7, CD4, CD8, and TCR) and single-cell RNA sequencing to dissect the transcriptomic consequences of reduced [PSMA7](/details-gene/5688) function on lineage commitment and cell cycle exit. **Therapeutic Potential:** As a core component of the proteasome, [PSMA7](/details-gene/5688) represents a node within a well-validated therapeutic target class. Proteasome inhibitors (e.g., Bortezomib, Carfilzomib) are already used in oncology, particularly for hematological malignancies. The therapeutic strategy would be **inhibition**, aiming to disrupt the protein homeostasis of rapidly dividing cancer cells that are highly dependent on the proteasome. However, targeting [PSMA7](/details-gene/5688) specifically may not offer a significant therapeutic window over pan-proteasome inhibitors, as its function is essential in most healthy dividing cells. Therefore, its potential as a standalone target is likely limited by systemic toxicity, though it remains a key component of the machinery targeted by existing and future proteasome-inhibiting drugs.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Proteasome subunit RC6-1

Genular Protein ID: 871818572

Symbol: PSA7_HUMAN

Name: Proteasome subunit RC6-1

UniProtKB Accession Codes:

O14818 B2R515 Q5JXJ2 Q9BR53 Q9H4K5 Q9UEU8

Database IDs:

Citations:

PubMed ID: 8764072

Title: Proteasome complex as a potential cellular target of hepatitis B virus X protein.

PubMed ID: 8764072

DOI: 10.1128/jvi.70.8.5582-5591.1996

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8610016

Title: A role for the proteasome regulator PA28alpha in antigen presentation.

PubMed ID: 8610016

DOI: 10.1038/381166a0

PubMed ID: 10748218

Title: Structural and functional characterization of interaction between hepatitis B virus X protein and the proteasome complex.

PubMed ID: 10748218

DOI: 10.1074/jbc.m910378199

PubMed ID: 11389899

Title: Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7.

PubMed ID: 11389899

DOI: 10.1016/s0014-5793(01)02499-1

PubMed ID: 11713272

Title: Involvement of proteasome alpha-subunit PSMA7 in hepatitis C virus internal ribosome entry site-mediated translation.

PubMed ID: 11713272

DOI: 10.1128/mcb.21.24.8357-8364.2001

PubMed ID: 11574696

Title: C-SPACE (cleavage-specific amplification of cDNA ends): a novel method of ribozyme-mediated gene identification.

PubMed ID: 11574696

DOI: 10.1093/nar/29.19.e94

PubMed ID: 12119296

Title: Proteasome activity is required for androgen receptor transcriptional activity via regulation of androgen receptor nuclear translocation and interaction with coregulators in prostate cancer cells.

PubMed ID: 12119296

DOI: 10.1074/jbc.m204751200

PubMed ID: 12181345

Title: Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome.

PubMed ID: 12181345

DOI: 10.1091/mbc.e02-03-0122

PubMed ID: 14550573

Title: Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits.

PubMed ID: 14550573

DOI: 10.1016/s0014-5793(03)01025-1

PubMed ID: 15244466

Title: 20S proteasome prevents aggregation of heat-denatured proteins without PA700 regulatory subcomplex like a molecular chaperone.

PubMed ID: 15244466

DOI: 10.1021/bm049957a

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 14998988

Title: The proteasome alpha-subunit XAPC7 interacts specifically with Rab7 and late endosomes.

PubMed ID: 14998988

DOI: 10.1074/jbc.m401022200

PubMed ID: 15987638

Title: Parkin interacts with the proteasome subunit alpha4.

PubMed ID: 15987638

DOI: 10.1016/j.febslet.2005.06.003

PubMed ID: 16251969

Title: A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes.

PubMed ID: 16251969

DOI: 10.1038/nature04106

PubMed ID: 16678104

Title: Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation.

PubMed ID: 16678104

DOI: 10.1016/j.molcel.2006.04.007

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 18202793

Title: The proteasome subunit PSMA7 located on the 20q13 amplicon is overexpressed and associated with liver metastasis in colorectal cancer.

PubMed ID: 18202793

PubMed ID: 19362550

Title: Endothelial monocyte activating polypeptide-II modulates endothelial cell responses by degrading hypoxia-inducible factor-1alpha through interaction with PSMA7, a component of the proteasome.

PubMed ID: 19362550

DOI: 10.1016/j.yexcr.2009.03.021

PubMed ID: 19734229

Title: Negative regulation of MAVS-mediated innate immune response by PSMA7.

PubMed ID: 19734229

DOI: 10.4049/jimmunol.0901646

PubMed ID: 19442227

Title: PSMA7, a potential biomarker of diseases.

PubMed ID: 19442227

DOI: 10.2174/092986609788167824

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23495936

Title: Molecular architecture and assembly of the eukaryotic proteasome.

PubMed ID: 23495936

DOI: 10.1146/annurev-biochem-060410-150257

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27176742

Title: Human 20S proteasome activity towards fluorogenic peptides of various chain lengths.

PubMed ID: 27176742

DOI: 10.1515/hsz-2016-0176

PubMed ID: 26133119

Title: Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core.

PubMed ID: 26133119

DOI: 10.1038/ncomms8573

PubMed ID: 25599644

Title: Crystal structure of the human 20S proteasome in complex with carfilzomib.

PubMed ID: 25599644

DOI: 10.1016/j.str.2014.11.017

PubMed ID: 27428775

Title: An atomic structure of the human 26S proteasome.

PubMed ID: 27428775

DOI: 10.1038/nsmb.3273

PubMed ID: 27342858

Title: Structure of the human 26S proteasome at a resolution of 3.9 Aa.

PubMed ID: 27342858

DOI: 10.1073/pnas.1608050113

PubMed ID: 27493187

Title: The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design.

PubMed ID: 27493187

DOI: 10.1126/science.aaf8993

PubMed ID: 34711951

Title: AKIRIN2 controls the nuclear import of proteasomes in vertebrates.

PubMed ID: 34711951

DOI: 10.1038/s41586-021-04035-8

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

Sequence Information:

Length: 248
Mass: 27887
Checksum: 5DD0276A1C2DEF91
Sequence:

MSYDRAITVF SPDGHLFQVE YAQEAVKKGS TAVGVRGRDI VVLGVEKKSV AKLQDERTVR 
KICALDDNVC MAFAGLTADA RIVINRARVE CQSHRLTVED PVTVEYITRY IASLKQRYTQ 
SNGRRPFGIS ALIVGFDFDG TPRLYQTDPS GTYHAWKANA IGRGAKSVRE FLEKNYTDEA 
IETDDLTIKL VIKALLEVVQ SGGKNIELAV MRRDQSLKIL NPEEIEKYVA EIEKEKEENE 
KKKQKKAS

	Overall overall
	Acute kidney failure MONDO0002492
	Adrenal gland UBERON0002369
	Alzheimer disease MONDO0004975
	Amyotrophic lateral sclerosis MONDO0004976
	Ascending colon UBERON0001156
	\|— Ascending colon Healthy UBERON0001156_PATO0000461
	Atherosclerosis MONDO0005311
	Axilla UBERON0009472
	Basal cell carcinoma MONDO0020804
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	\|— Brain Healthy UBERON0000955_PATO0000461
	Breast UBERON0000310
	\|— Breast Breast cancer UBERON0000310_MONDO0007254
	\|— Breast Healthy UBERON0000310_PATO0000461
	\|— Breast cancer MONDO0007254
	Bronchus UBERON0002185
	Caecum UBERON0001153
	\|— Caecum Healthy UBERON0001153_PATO0000461
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Cerebrospinal fluid UBERON0001359
	Chronic kidney disease MONDO0005300
	Colon UBERON0001155
	\|— Colon Healthy UBERON0001155_PATO0000461
	\|— Colonic epithelium UBERON0000397
	\|— Colonic epithelium Healthy UBERON0000397_PATO0000461
	Colorectal cancer MONDO0005575
	Colorectum UBERON0012652
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	Duodenum UBERON0002114
	\|— Duodenum Healthy UBERON0002114_PATO0000461
	Fallopian tube UBERON0003889
	Fovea centralis UBERON0001786
	\|— Fovea centralis Healthy UBERON0001786_PATO0000461
	Frontal cortex UBERON0001870
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	\|— Heart right ventricle Healthy UBERON0002080_PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileal epithelium UBERON0008345
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	\|— Ileum lamina propria UBERON8600035
	Interventricular septum UBERON0002094
	Islet of Langerhans UBERON0000006
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Lamina propria of small intestine UBERON0001238
	Liver UBERON0002107
	\|— Liver Breast cancer UBERON0002107_MONDO0007254
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung Renal cell carcinoma UBERON0002048_MONDO0005086
	\|— Lung adenocarcinoma MONDO0005061
	\|— Lung parenchyma UBERON0008946
	Lymph node UBERON0000029
	\|— Lymph node Healthy UBERON0000029_PATO0000461
	\|— Lymph node Metastatic melanoma UBERON0000029_MONDO0005191
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Mesenteric lymph node UBERON0002509
	\|— Mesenteric lymph node Healthy UBERON0002509_PATO0000461
	Metastatic melanoma MONDO0005191
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neuroblastoma MONDO0005072
	Nonpapillary renal cell carcinoma MONDO0007763
	Occipital cortex UBERON0016540
	Ovary UBERON0000992
	\|— Ovary Healthy UBERON0000992_PATO0000461
	Pancreas UBERON0001264
	\|— Pancreas Healthy UBERON0001264_PATO0000461
	Parkinson disease MONDO0005180
	Peripheral region of retina UBERON0013682
	\|— Peripheral region of retina Healthy UBERON0013682_PATO0000461
	Placenta UBERON0001987
	\|— Placenta Healthy UBERON0001987_PATO0000461
	Pleural effusion UBERON0000175
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Prefrontal cortex UBERON0000451
	Primary motor cortex UBERON0001384
	Prostate gland UBERON0002367
	Renal cell carcinoma MONDO0005086
	Renal medulla UBERON0000362
	\|— Renal medulla Healthy UBERON0000362_PATO0000461
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Schizophrenia MONDO0005090
	Sigmoid colon UBERON0001159
	\|— Sigmoid colon Healthy UBERON0001159_PATO0000461
	Skin of body UBERON0002097
	\|— Skin of body Healthy UBERON0002097_PATO0000461
	Small cell lung carcinoma MONDO0008433
	Small intestine UBERON0002108
	\|— Small intestine Healthy UBERON0002108_PATO0000461
	Spleen UBERON0002106
	\|— Spleen Healthy UBERON0002106_PATO0000461
	Stomach UBERON0000945
	\|— Stomach Healthy UBERON0000945_PATO0000461
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	Thymus UBERON0002370
	\|— Thymus Healthy UBERON0002370_PATO0000461
	Trachea UBERON0003126
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Upper lobe of left lung UBERON0008952

Details for: PSMA7

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

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Other Information

Proteasome complex as a potential cellular target of hepatitis B virus X protein. PubMed ID: 8764072

Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. PubMed ID: 11042152

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A role for the proteasome regulator PA28alpha in antigen presentation. PubMed ID: 8610016

Structural and functional characterization of interaction between hepatitis B virus X protein and the proteasome complex. PubMed ID: 10748218

Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7. PubMed ID: 11389899

Involvement of proteasome alpha-subunit PSMA7 in hepatitis C virus internal ribosome entry site-mediated translation. PubMed ID: 11713272

C-SPACE (cleavage-specific amplification of cDNA ends): a novel method of ribozyme-mediated gene identification. PubMed ID: 11574696

Proteasome activity is required for androgen receptor transcriptional activity via regulation of androgen receptor nuclear translocation and interaction with coregulators in prostate cancer cells. PubMed ID: 12119296

Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome. PubMed ID: 12181345

Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits. PubMed ID: 14550573

20S proteasome prevents aggregation of heat-denatured proteins without PA700 regulatory subcomplex like a molecular chaperone. PubMed ID: 15244466

An unappreciated role for RNA surveillance. PubMed ID: 14759258

The proteasome alpha-subunit XAPC7 interacts specifically with Rab7 and late endosomes. PubMed ID: 14998988

Parkin interacts with the proteasome subunit alpha4. PubMed ID: 15987638

A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes. PubMed ID: 16251969

Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation. PubMed ID: 16678104

Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. PubMed ID: 17323924

The proteasome subunit PSMA7 located on the 20q13 amplicon is overexpressed and associated with liver metastasis in colorectal cancer. PubMed ID: 18202793

Endothelial monocyte activating polypeptide-II modulates endothelial cell responses by degrading hypoxia-inducible factor-1alpha through interaction with PSMA7, a component of the proteasome. PubMed ID: 19362550

Negative regulation of MAVS-mediated innate immune response by PSMA7. PubMed ID: 19734229

PSMA7, a potential biomarker of diseases. PubMed ID: 19442227

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Molecular architecture and assembly of the eukaryotic proteasome. PubMed ID: 23495936

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Human 20S proteasome activity towards fluorogenic peptides of various chain lengths. PubMed ID: 27176742

Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core. PubMed ID: 26133119

Crystal structure of the human 20S proteasome in complex with carfilzomib. PubMed ID: 25599644

An atomic structure of the human 26S proteasome. PubMed ID: 27428775

Structure of the human 26S proteasome at a resolution of 3.9 Aa. PubMed ID: 27342858

The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. PubMed ID: 27493187

AKIRIN2 controls the nuclear import of proteasomes in vertebrates. PubMed ID: 34711951

Diagnostic exome sequencing in persons with severe intellectual disability. PubMed ID: 23033978