PDE4D | ENSG00000113448 | NCBI 5144

Details for: PDE4D

Gene ID: 5144

Symbol: PDE4D

Ensembl ID: ENSG00000113448

Description: phosphodiesterase 4D

Associated with

Cellular responses to mechanical stimuli
(R-HSA-9855142)
Cellular responses to stimuli
(R-HSA-8953897)
Darpp-32 events
(R-HSA-180024)
G alpha (i) signalling events
(R-HSA-418594)
G alpha (s) signalling events
(R-HSA-418555)
Gpcr downstream signalling
(R-HSA-388396)
Opioid signalling
(R-HSA-111885)
Response of endothelial cells to shear stress
(R-HSA-9860931)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by piezo1 and integrins in endothelial cells
(R-HSA-9860927)
3',5'-cyclic-amp phosphodiesterase activity
(GO:0004115)
3',5'-cyclic-gmp phosphodiesterase activity
(GO:0047555)
3',5'-cyclic-nucleotide phosphodiesterase activity
(GO:0004114)
Adrenergic receptor signaling pathway
(GO:0071875)
Apical plasma membrane
(GO:0016324)
Atpase binding
(GO:0051117)
Beta-2 adrenergic receptor binding
(GO:0031698)
Calcium channel complex
(GO:0034704)
Calcium channel regulator activity
(GO:0005246)
Camp-mediated signaling
(GO:0019933)
Camp binding
(GO:0030552)
Camp catabolic process
(GO:0006198)
Cellular response to camp
(GO:0071320)
Cellular response to epinephrine stimulus
(GO:0071872)
Centrosome
(GO:0005813)
Cytosol
(GO:0005829)
Enzyme binding
(GO:0019899)
Establishment of endothelial barrier
(GO:0061028)
Heterocyclic compound binding
(GO:1901363)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Negative regulation of adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0106072)
Negative regulation of heart contraction
(GO:0045822)
Negative regulation of peptidyl-serine phosphorylation
(GO:0033137)
Negative regulation of relaxation of cardiac muscle
(GO:1901898)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Positive regulation of heart rate
(GO:0010460)
Positive regulation of interleukin-2 production
(GO:0032743)
Positive regulation of interleukin-5 production
(GO:0032754)
Positive regulation of type ii interferon production
(GO:0032729)
Protein binding
(GO:0005515)
Regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
(GO:1902514)
Regulation of cardiac muscle cell contraction
(GO:0086004)
Regulation of cell communication by electrical coupling involved in cardiac conduction
(GO:1901844)
Regulation of heart rate
(GO:0002027)
Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
(GO:0010880)
Scaffold protein binding
(GO:0097110)
Signaling receptor regulator activity
(GO:0030545)
T cell receptor signaling pathway
(GO:0050852)
Transmembrane transporter binding
(GO:0044325)
Voltage-gated calcium channel complex
(GO:0005891)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 661.5439
Cell Significance Index: -102.9000
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 401.7846
Cell Significance Index: -101.9100
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 218.6296
Cell Significance Index: -103.2200
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 210.8763
Cell Significance Index: -85.6700
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 154.3913
Cell Significance Index: -103.6000
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 89.9823
Cell Significance Index: -85.9100
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 83.5391
Cell Significance Index: -103.0000
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 36.3550
Cell Significance Index: -97.3900
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 33.2817
Cell Significance Index: -72.8400
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 31.1286
Cell Significance Index: -95.6100
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 26.2541
Cell Significance Index: -103.6000
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 17.6436
Cell Significance Index: 108.8600
Cell Name: type I muscle cell (CL0002211)
Fold Change: 15.0951
Cell Significance Index: 368.3100
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 11.6902
Cell Significance Index: 103.7700
Cell Name: type II muscle cell (CL0002212)
Fold Change: 11.4198
Cell Significance Index: 184.2600
Cell Name: cortical interneuron (CL0008031)
Fold Change: 10.8349
Cell Significance Index: 259.8500
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 8.6057
Cell Significance Index: 528.9500
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 8.5821
Cell Significance Index: 220.6000
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 8.2191
Cell Significance Index: 3730.4000
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 7.3901
Cell Significance Index: 210.8900
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 6.7806
Cell Significance Index: 2432.0800
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 5.6289
Cell Significance Index: 248.9800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 4.8042
Cell Significance Index: 368.6700
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 4.6639
Cell Significance Index: 313.6000
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 4.4055
Cell Significance Index: 3047.0000
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 4.3127
Cell Significance Index: 163.3100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 4.1210
Cell Significance Index: 826.6600
Cell Name: neoplastic cell (CL0001063)
Fold Change: 3.9182
Cell Significance Index: 777.5800
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 3.6941
Cell Significance Index: 6955.5600
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 3.2430
Cell Significance Index: 90.6300
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 3.2152
Cell Significance Index: 32.4400
Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: 3.1635
Cell Significance Index: 42.2000
Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
Fold Change: 2.6241
Cell Significance Index: 26.2600
Cell Name: hippocampal interneuron (CL1001569)
Fold Change: 2.4783
Cell Significance Index: 32.1400
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 2.4692
Cell Significance Index: 25.5800
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 2.3657
Cell Significance Index: 35.9900
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.9944
Cell Significance Index: 1266.6800
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 1.7191
Cell Significance Index: 29.4600
Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: 1.6694
Cell Significance Index: 17.3900
Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.6076
Cell Significance Index: 35.2000
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.4727
Cell Significance Index: 82.6400
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 1.3119
Cell Significance Index: 136.6000
Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.2848
Cell Significance Index: 2369.4800
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.1632
Cell Significance Index: 189.1900
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.9277
Cell Significance Index: 19.8300
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.5894
Cell Significance Index: 8.7000
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.3730
Cell Significance Index: 507.1100
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3295
Cell Significance Index: 35.8500
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3136
Cell Significance Index: 283.1400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2811
Cell Significance Index: 50.6800
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.2654
Cell Significance Index: 408.6200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1864
Cell Significance Index: 22.9200
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1227
Cell Significance Index: 23.3500
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.0953
Cell Significance Index: 1.3700
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.0217
Cell Significance Index: -0.3200
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.0497
Cell Significance Index: -0.3000
Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.0526
Cell Significance Index: -5.2000
Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: -0.0551
Cell Significance Index: -0.7700
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0566
Cell Significance Index: -1.6300
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0699
Cell Significance Index: -51.7600
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0831
Cell Significance Index: -2.9200
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0859
Cell Significance Index: -65.0400
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0948
Cell Significance Index: -59.1900
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0961
Cell Significance Index: -42.5000
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.1065
Cell Significance Index: -58.1500
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.1066
Cell Significance Index: -78.1700
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1102
Cell Significance Index: -13.0000
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1118
Cell Significance Index: -63.0300
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.1521
Cell Significance Index: -3.3000
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.1713
Cell Significance Index: -2.4600
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2177
Cell Significance Index: -31.6400
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2259
Cell Significance Index: -26.3300
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.2478
Cell Significance Index: -4.9000
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.3056
Cell Significance Index: -87.9200
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.3462
Cell Significance Index: -72.9200
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.4282
Cell Significance Index: -19.4100
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.4837
Cell Significance Index: -82.6000
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.4935
Cell Significance Index: -29.6300
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.5140
Cell Significance Index: -52.5100
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.5904
Cell Significance Index: -8.4600
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.5997
Cell Significance Index: -82.3500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.6179
Cell Significance Index: -28.8100
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.6436
Cell Significance Index: -21.0700
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.6870
Cell Significance Index: -21.8800
Cell Name: lactocyte (CL0002325)
Fold Change: -0.7139
Cell Significance Index: -92.2300
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.7517
Cell Significance Index: -8.1900
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.7903
Cell Significance Index: -49.8100
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.7921
Cell Significance Index: -54.7800
Cell Name: odontoblast (CL0000060)
Fold Change: -0.8299
Cell Significance Index: -106.3900
Cell Name: chandelier cell (CL4023083)
Fold Change: -0.8793
Cell Significance Index: -7.1000
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.9102
Cell Significance Index: -11.3500
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.9414
Cell Significance Index: -19.9800
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.9553
Cell Significance Index: -23.8800
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.9554
Cell Significance Index: -109.4600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.9847
Cell Significance Index: -51.1500
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.9945
Cell Significance Index: -113.5200
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -1.0727
Cell Significance Index: -21.5400
Cell Name: early pro-B cell (CL0002046)
Fold Change: -1.0773
Cell Significance Index: -69.5000
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -1.1622
Cell Significance Index: -54.6200
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.1648
Cell Significance Index: -92.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Enzymatic Activity:** PDE4D is a 3',5'-cyclic-nucleotide phosphodiesterase, which degrades cAMP and cGMP, thereby regulating their levels and downstream signaling pathways. 2. **Cellular Expression:** PDE4D is highly expressed in immune cells, neurons, skeletal muscle fibers, macroglial cells, and cardiac muscle cells, suggesting its widespread involvement in various physiological processes. 3. **Regulation of Signaling Pathways:** PDE4D modulates signaling pathways involved in cardiovascular function, immune response, and cellular communication, including the adrenergic receptor signaling pathway, G-protein coupled receptor (GPCR) signaling, and T-cell receptor signaling. **Pathways and Functions:** 1. **Cardiovascular Function:** PDE4D regulates heart rate, cardiac muscle cell contraction, and relaxation, highlighting its role in cardiovascular homeostasis. 2. **Immune Response:** PDE4D modulates immune cell function, including the regulation of interleukin-2, interleukin-5, and type II interferon production, suggesting its involvement in immune regulation. 3. **Neurological Function:** PDE4D is expressed in neuronal cells, where it may regulate synaptic plasticity, neuronal excitability, and neurotransmitter release. 4. **Cellular Signaling:** PDE4D interacts with various signaling molecules, including adrenergic receptors, GPCRs, and scaffold proteins, to regulate cellular responses. **Clinical Significance:** 1. **Cardiovascular Diseases:** Alterations in PDE4D expression or activity may contribute to cardiovascular diseases, such as hypertension, heart failure, and arrhythmias. 2. **Immune-Related Disorders:** Dysregulation of PDE4D may be involved in immune-related disorders, including rheumatoid arthritis, multiple sclerosis, and asthma. 3. **Neurological Disorders:** PDE4D may play a role in the pathogenesis of neurological disorders, such as Alzheimer's disease, Parkinson's disease, and epilepsy. 4. **Therapeutic Applications:** PDE4D inhibitors have been explored as potential therapeutic agents for cardiovascular and immune-related diseases, including hypertension, heart failure, and inflammatory disorders. In conclusion, PDE4D is a complex gene that plays a critical role in regulating various physiological and pathological processes, including cardiovascular function, immune response, and cellular signaling. Further research is needed to fully understand the mechanisms by which PDE4D influences these processes and to explore its therapeutic potential.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

DPDE3

Genular Protein ID: 3376901266

Symbol: PDE4D_HUMAN

Name: DPDE3

UniProtKB Accession Codes:

Q08499 O43433 Q13549 Q13550 Q13551 Q7Z2L8 Q8IV84 Q8IVA9 Q8IVD2 Q8IVD3 Q96HL4 Q9HCX7

Database IDs:

Citations:

PubMed ID: 8413254

Title: A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.

PubMed ID: 8413254

DOI: 10.1128/mcb.13.10.6558-6571.1993

PubMed ID: 8797812

Title: Identification of cyclic AMP-phosphodiesterase variants from the PDE4D gene expressed in human peripheral mononuclear cells.

PubMed ID: 8797812

DOI: 10.1016/0014-5793(96)00300-6

PubMed ID: 8125310

Title: Isolation of a cDNA encoding a human rolipram-sensitive cyclic AMP phosphodiesterase (PDE IVD).

PubMed ID: 8125310

DOI: 10.1016/0378-1119(94)90818-4

PubMed ID: 9371713

Title: Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene.

PubMed ID: 9371713

DOI: 10.1042/bj3280539

PubMed ID: 10913353

Title: Phosphodiesterases 4D and 7A splice variants in the response of HUVEC cells to TNF-alpha1.

PubMed ID: 10913353

DOI: 10.1006/bbrc.2000.3146

PubMed ID: 12834813

Title: Cloning and characterization of novel PDE4D isoforms PDE4D6 and PDE4D7.

PubMed ID: 12834813

DOI: 10.1016/s0898-6568(03)00042-1

PubMed ID: 14517540

Title: The gene encoding phosphodiesterase 4D confers risk of ischemic stroke.

PubMed ID: 14517540

DOI: 10.1038/ng1245

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12193273

Title: Delineation of RAID1, the RACK1 interaction domain located within the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5.

PubMed ID: 12193273

DOI: 10.1186/1471-2091-3-24

PubMed ID: 14500724

Title: The unique amino-terminal region of the PDE4D5 cAMP phosphodiesterase isoform confers preferential interaction with beta-arrestins.

PubMed ID: 14500724

DOI: 10.1074/jbc.m303772200

PubMed ID: 15131123

Title: The oligomerization state determines regulatory properties and inhibitor sensitivity of type 4 cAMP-specific phosphodiesterases.

PubMed ID: 15131123

DOI: 10.1074/jbc.m312687200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17006457

Title: Many hypotheses but no replication for the association between PDE4D and stroke.

PubMed ID: 17006457

DOI: 10.1038/ng1006-1091

PubMed ID: 17244609

Title: Dynamic regulation of cystic fibrosis transmembrane conductance regulator by competitive interactions of molecular adaptors.

PubMed ID: 17244609

DOI: 10.1074/jbc.m610857200

PubMed ID: 17519386

Title: PDE4B5, a novel, super-short, brain-specific cAMP phosphodiesterase-4 variant whose isoform-specifying N-terminal region is identical to that of cAMP phosphodiesterase-4D6 (PDE4D6).

PubMed ID: 17519386

DOI: 10.1124/jpet.107.122218

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20196770

Title: Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK.

PubMed ID: 20196770

DOI: 10.1042/bj20091672

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 12387865

Title: Crystal structure of phosphodiesterase 4D and inhibitor complex.

PubMed ID: 12387865

DOI: 10.1016/s0014-5793(02)03396-3

PubMed ID: 14609333

Title: The crystal structure of AMP-bound PDE4 suggests a mechanism for phosphodiesterase catalysis.

PubMed ID: 14609333

DOI: 10.1021/bi034653e

PubMed ID: 12842049

Title: Three-dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity.

PubMed ID: 12842049

DOI: 10.1016/s0969-2126(03)00123-0

PubMed ID: 14668322

Title: Crystal structures of phosphodiesterases 4 and 5 in complex with inhibitor 3-isobutyl-1-methylxanthine suggest a conformation determinant of inhibitor selectivity.

PubMed ID: 14668322

DOI: 10.1074/jbc.m311556200

PubMed ID: 15003452

Title: Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram.

PubMed ID: 15003452

DOI: 10.1016/j.jmb.2004.01.040

PubMed ID: 15260978

Title: A glutamine switch mechanism for nucleotide selectivity by phosphodiesterases.

PubMed ID: 15260978

DOI: 10.1016/j.molcel.2004.07.005

PubMed ID: 15576036

Title: Structural basis for the activity of drugs that inhibit phosphodiesterases.

PubMed ID: 15576036

DOI: 10.1016/j.str.2004.10.004

PubMed ID: 15685167

Title: A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design.

PubMed ID: 15685167

DOI: 10.1038/nbt1059

PubMed ID: 16539372

Title: Enantiomer discrimination illustrated by the high resolution crystal structures of type 4 phosphodiesterase.

PubMed ID: 16539372

DOI: 10.1021/jm051273d

PubMed ID: 17727341

Title: Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors.

PubMed ID: 17727341

DOI: 10.1042/bj20070970

PubMed ID: 17900862

Title: 1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, beta-arrestin and RACK1.

PubMed ID: 17900862

DOI: 10.1016/j.cellsig.2007.08.015

PubMed ID: 17582435

Title: The molecular basis for different recognition of substrates by phosphodiesterase families 4 and 10.

PubMed ID: 17582435

DOI: 10.1016/j.jmb.2007.05.060

PubMed ID: 22464250

Title: Exome sequencing identifies PDE4D mutations as another cause of acrodysostosis.

PubMed ID: 22464250

DOI: 10.1016/j.ajhg.2012.03.003

PubMed ID: 22464252

Title: Exome sequencing identifies PDE4D mutations in acrodysostosis.

PubMed ID: 22464252

DOI: 10.1016/j.ajhg.2012.03.004

PubMed ID: 23043190

Title: PRKAR1A and PDE4D mutations cause acrodysostosis but two distinct syndromes with or without GPCR-signaling hormone resistance.

PubMed ID: 23043190

DOI: 10.1210/jc.2012-2326

PubMed ID: 23033274

Title: Identification of novel mutations confirms Pde4d as a major gene causing acrodysostosis.

PubMed ID: 23033274

DOI: 10.1002/humu.22222

Sequence Information:

Length: 809
Mass: 91115
Checksum: 7A4773DD3A044F57
Sequence:

MEAEGSSAPA RAGSGEGSDS AGGATLKAPK HLWRHEQHHQ YPLRQPQFRL LHPHHHLPPP 
PPPSPQPQPQ CPLQPPPPPP LPPPPPPPGA ARGRYASSGA TGRVRHRGYS DTERYLYCRA 
MDRTSYAVET GHRPGLKKSR MSWPSSFQGL RRFDVDNGTS AGRSPLDPMT SPGSGLILQA 
NFVHSQRRES FLYRSDSDYD LSPKSMSRNS SIASDIHGDD LIVTPFAQVL ASLRTVRNNF 
AALTNLQDRA PSKRSPMCNQ PSINKATITE EAYQKLASET LEELDWCLDQ LETLQTRHSV 
SEMASNKFKR MLNRELTHLS EMSRSGNQVS EFISNTFLDK QHEVEIPSPT QKEKEKKKRP 
MSQISGVKKL MHSSSLTNSS IPRFGVKTEQ EDVLAKELED VNKWGLHVFR IAELSGNRPL 
TVIMHTIFQE RDLLKTFKIP VDTLITYLMT LEDHYHADVA YHNNIHAADV VQSTHVLLST 
PALEAVFTDL EILAAIFASA IHDVDHPGVS NQFLINTNSE LALMYNDSSV LENHHLAVGF 
KLLQEENCDI FQNLTKKQRQ SLRKMVIDIV LATDMSKHMN LLADLKTMVE TKKVTSSGVL 
LLDNYSDRIQ VLQNMVHCAD LSNPTKPLQL YRQWTDRIME EFFRQGDRER ERGMEISPMC 
DKHNASVEKS QVGFIDYIVH PLWETWADLV HPDAQDILDT LEDNREWYQS TIPQSPSPAP 
DDPEEGRQGQ TEKFQFELTL EEDGESDTEK DSGSQVEEDT SCSDSKTLCT QDSESTEIPL 
DEQVEEEAVG EEEESQPEAC VIDDRSPDT

Database document:

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Details for: PDE4D

Associated with

Cells (max top 100)

Other Information

A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs. PubMed ID: 8413254

Identification of cyclic AMP-phosphodiesterase variants from the PDE4D gene expressed in human peripheral mononuclear cells. PubMed ID: 8797812

Isolation of a cDNA encoding a human rolipram-sensitive cyclic AMP phosphodiesterase (PDE IVD). PubMed ID: 8125310

Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene. PubMed ID: 9371713

Phosphodiesterases 4D and 7A splice variants in the response of HUVEC cells to TNF-alpha1. PubMed ID: 10913353

Cloning and characterization of novel PDE4D isoforms PDE4D6 and PDE4D7. PubMed ID: 12834813

The gene encoding phosphodiesterase 4D confers risk of ischemic stroke. PubMed ID: 14517540

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Delineation of RAID1, the RACK1 interaction domain located within the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5. PubMed ID: 12193273

The unique amino-terminal region of the PDE4D5 cAMP phosphodiesterase isoform confers preferential interaction with beta-arrestins. PubMed ID: 14500724

The oligomerization state determines regulatory properties and inhibitor sensitivity of type 4 cAMP-specific phosphodiesterases. PubMed ID: 15131123

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Many hypotheses but no replication for the association between PDE4D and stroke. PubMed ID: 17006457

Dynamic regulation of cystic fibrosis transmembrane conductance regulator by competitive interactions of molecular adaptors. PubMed ID: 17244609

PDE4B5, a novel, super-short, brain-specific cAMP phosphodiesterase-4 variant whose isoform-specifying N-terminal region is identical to that of cAMP phosphodiesterase-4D6 (PDE4D6). PubMed ID: 17519386

Phosphoproteome of resting human platelets. PubMed ID: 18088087

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK. PubMed ID: 20196770

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Crystal structure of phosphodiesterase 4D and inhibitor complex. PubMed ID: 12387865

The crystal structure of AMP-bound PDE4 suggests a mechanism for phosphodiesterase catalysis. PubMed ID: 14609333

Three-dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity. PubMed ID: 12842049

Crystal structures of phosphodiesterases 4 and 5 in complex with inhibitor 3-isobutyl-1-methylxanthine suggest a conformation determinant of inhibitor selectivity. PubMed ID: 14668322

Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram. PubMed ID: 15003452

A glutamine switch mechanism for nucleotide selectivity by phosphodiesterases. PubMed ID: 15260978

Structural basis for the activity of drugs that inhibit phosphodiesterases. PubMed ID: 15576036

A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design. PubMed ID: 15685167

Enantiomer discrimination illustrated by the high resolution crystal structures of type 4 phosphodiesterase. PubMed ID: 16539372

Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors. PubMed ID: 17727341

1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, beta-arrestin and RACK1. PubMed ID: 17900862

The molecular basis for different recognition of substrates by phosphodiesterase families 4 and 10. PubMed ID: 17582435

Exome sequencing identifies PDE4D mutations as another cause of acrodysostosis. PubMed ID: 22464250

Exome sequencing identifies PDE4D mutations in acrodysostosis. PubMed ID: 22464252

PRKAR1A and PDE4D mutations cause acrodysostosis but two distinct syndromes with or without GPCR-signaling hormone resistance. PubMed ID: 23043190

Identification of novel mutations confirms Pde4d as a major gene causing acrodysostosis. PubMed ID: 23033274