Details for: BTG2

Gene ID: 7832

Symbol: BTG2

Ensembl ID: ENSG00000159388

Description: BTG anti-proliferation factor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 431.7072
    Cell Significance Index: -67.1500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 272.0749
    Cell Significance Index: -69.0100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 196.9425
    Cell Significance Index: -81.1300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 165.3172
    Cell Significance Index: -78.0500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 155.9920
    Cell Significance Index: -80.2400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 116.0617
    Cell Significance Index: -77.8800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 58.8910
    Cell Significance Index: -72.6100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.7970
    Cell Significance Index: -61.0700
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 20.4296
    Cell Significance Index: 10.2600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 19.5233
    Cell Significance Index: -77.0400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 18.0273
    Cell Significance Index: -55.3700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.2146
    Cell Significance Index: -31.1100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 7.2998
    Cell Significance Index: 168.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 6.5311
    Cell Significance Index: 177.7700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 5.3341
    Cell Significance Index: 655.8800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 5.0964
    Cell Significance Index: 918.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.6229
    Cell Significance Index: 188.2000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.5594
    Cell Significance Index: 62.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.2631
    Cell Significance Index: 152.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 3.2431
    Cell Significance Index: 2025.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.5261
    Cell Significance Index: 188.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.5202
    Cell Significance Index: 346.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.5160
    Cell Significance Index: 114.0400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 2.3796
    Cell Significance Index: 58.0600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.0721
    Cell Significance Index: 337.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.9864
    Cell Significance Index: 196.5000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.8536
    Cell Significance Index: 819.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.7698
    Cell Significance Index: 50.9900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.7537
    Cell Significance Index: 224.8100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.5630
    Cell Significance Index: 100.8400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.5549
    Cell Significance Index: 12.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.3587
    Cell Significance Index: 96.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3117
    Cell Significance Index: 716.3400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3056
    Cell Significance Index: 78.3800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1972
    Cell Significance Index: 227.8300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.1722
    Cell Significance Index: 200.1600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.1375
    Cell Significance Index: 30.4800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.1136
    Cell Significance Index: 10.2600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.0246
    Cell Significance Index: 120.8400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.6426
    Cell Significance Index: 7.3000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6347
    Cell Significance Index: 48.7100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5856
    Cell Significance Index: 40.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5331
    Cell Significance Index: 68.8800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5111
    Cell Significance Index: 14.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4516
    Cell Significance Index: 89.6200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3543
    Cell Significance Index: 319.9000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3003
    Cell Significance Index: 4.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2815
    Cell Significance Index: 13.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2168
    Cell Significance Index: 408.1200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1445
    Cell Significance Index: 2.6700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1370
    Cell Significance Index: 4.7600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1154
    Cell Significance Index: 73.2700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0649
    Cell Significance Index: 7.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0566
    Cell Significance Index: 41.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0031
    Cell Significance Index: -2.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0037
    Cell Significance Index: -0.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0338
    Cell Significance Index: -62.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0371
    Cell Significance Index: -27.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0407
    Cell Significance Index: -62.6500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0624
    Cell Significance Index: -43.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0630
    Cell Significance Index: -85.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0747
    Cell Significance Index: -26.7900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1011
    Cell Significance Index: -57.0200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1084
    Cell Significance Index: -2.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1135
    Cell Significance Index: -51.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1347
    Cell Significance Index: -27.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1369
    Cell Significance Index: -7.1900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1646
    Cell Significance Index: -34.6700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1666
    Cell Significance Index: -4.3800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2322
    Cell Significance Index: -6.2000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2544
    Cell Significance Index: -73.1900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.3016
    Cell Significance Index: -32.8000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3109
    Cell Significance Index: -45.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3870
    Cell Significance Index: -44.3400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4369
    Cell Significance Index: -13.9900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4577
    Cell Significance Index: -6.4200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4662
    Cell Significance Index: -12.4700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4672
    Cell Significance Index: -23.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5167
    Cell Significance Index: -60.2100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.6193
    Cell Significance Index: -6.5800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6325
    Cell Significance Index: -8.6300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.6817
    Cell Significance Index: -27.9300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7135
    Cell Significance Index: -74.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7645
    Cell Significance Index: -42.9000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.8334
    Cell Significance Index: -18.0600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9128
    Cell Significance Index: -72.2900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.9424
    Cell Significance Index: -5.8000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.9507
    Cell Significance Index: -27.9200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.9766
    Cell Significance Index: -16.3500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.0370
    Cell Significance Index: -69.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.0556
    Cell Significance Index: -64.8800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1349
    Cell Significance Index: -69.5800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.1690
    Cell Significance Index: -32.6700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -1.4394
    Cell Significance Index: -30.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.5125
    Cell Significance Index: -95.3300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.6202
    Cell Significance Index: -40.5000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.6244
    Cell Significance Index: -59.6300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.7257
    Cell Significance Index: -76.3300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -1.7270
    Cell Significance Index: -26.7200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.8102
    Cell Significance Index: -35.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Antiproliferative Function:** BTG2 exhibits anti-proliferative properties, inhibiting the progression of cells through the cell cycle and promoting cell death in response to DNA damage. 2. **Transcriptional Regulation:** BTG2 acts as a transcriptional regulator, modulating the expression of genes involved in cell cycle progression, DNA repair, and apoptosis. 3. **Tissue-Specific Expression:** BTG2 is significantly expressed in epithelial cells, immune cells, and stem cells, indicating its importance in maintaining tissue integrity and immune function. 4. **Interactions with Tp53:** BTG2 interacts with the tumor suppressor protein Tp53, modulating its transcriptional activity and regulating the expression of cell cycle genes. **Pathways and Functions:** 1. **Anterior/Posterior Pattern Specification:** BTG2 regulates the specification of anterior/posterior patterns in development, influencing the expression of genes involved in embryonic development. 2. **Negative Regulation of Cell Population Proliferation:** BTG2 inhibits the proliferation of cell populations, preventing excessive cell growth and maintaining tissue homeostasis. 3. **Negative Regulation of Mitotic Cell Cycle:** BTG2 regulates the mitotic cell cycle, inhibiting the progression of cells through the cell cycle and promoting cell death in response to DNA damage. 4. **Negative Regulation of Neuroblast Proliferation:** BTG2 inhibits the proliferation of neuroblasts, regulating the development and maturation of neurons. 5. **Negative Regulation of Transcription by RNA Polymerase II:** BTG2 regulates the expression of genes involved in transcription, modulating the activity of RNA polymerase II. **Clinical Significance:** 1. **Cancer Prevention:** BTG2's anti-proliferative properties make it a potential target for cancer prevention and therapy, as its dysregulation is associated with tumorigenesis. 2. **Immune System Regulation:** BTG2's expression in immune cells highlights its importance in maintaining immune function and preventing autoimmune diseases. 3. **Neurological Disorders:** BTG2's regulation of neuroblast proliferation and differentiation suggests its potential involvement in neurological disorders, such as neurodegenerative diseases. 4. **Tissue Repair and Regeneration:** BTG2's role in regulating stem cell proliferation and differentiation makes it a potential target for tissue repair and regeneration therapies. In conclusion, the BTG2 gene plays a critical role in regulating cell proliferation, differentiation, and survival, highlighting its importance in maintaining tissue integrity and immune function. Further research is needed to fully elucidate the mechanisms by which BTG2 regulates cellular processes and its potential applications in cancer prevention, immune system regulation, and neurological disorders.

Genular Protein ID: 3111485852

Symbol: BTG2_HUMAN

Name: Protein BTG2

UniProtKB Accession Codes:

P78543 A0A024R986 Q3KR25 Q5VUT0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 8 Ensembl 2 EvolutionaryTrace 1 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8944033

Title: Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway.

PubMed ID: 8944033

DOI: 10.1038/ng1296-482

PubMed ID: 11267995

Title: The gene PC3(TIS21/BTG2), prototype member of the PC3/BTG/TOB family: regulator in control of cell growth, differentiation, and DNA repair?

PubMed ID: 11267995

DOI: 10.1002/jcp.1062

PubMed ID: 11814693

Title: The human BTG2/TIS21/PC3 gene: genomic structure, transcriptional regulation and evaluation as a candidate tumor suppressor gene.

PubMed ID: 11814693

DOI: 10.1016/s0378-1119(01)00825-3

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9712883

Title: Interaction of BTG1 and p53-regulated BTG2 gene products with mCaf1, the murine homolog of a component of the yeast CCR4 transcriptional regulatory complex.

PubMed ID: 9712883

DOI: 10.1074/jbc.273.35.22563

PubMed ID: 11136725

Title: Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway.

PubMed ID: 11136725

DOI: 10.1074/jbc.m008201200

PubMed ID: 12771185

Title: BTG2 antiproliferative protein interacts with the human CCR4 complex existing in vivo in three cell-cycle-regulated forms.

PubMed ID: 12771185

DOI: 10.1242/jcs.00480

PubMed ID: 15788397

Title: Phosphorylation of serine 147 of tis21/BTG2/pc3 by p-Erk1/2 induces Pin-1 binding in cytoplasm and cell death.

PubMed ID: 15788397

DOI: 10.1074/jbc.m500318200

PubMed ID: 18337750

Title: The BTG2 protein is a general activator of mRNA deadenylation.

PubMed ID: 18337750

DOI: 10.1038/emboj.2008.43

PubMed ID: 18773938

Title: PRMT1 and Btg2 regulates neurite outgrowth of Neuro2a cells.

PubMed ID: 18773938

DOI: 10.1016/j.neulet.2008.08.065

PubMed ID: 23236473

Title: The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex.

PubMed ID: 23236473

DOI: 10.1371/journal.pone.0051331

PubMed ID: 18974182

Title: Crystal structures of human BTG2 and mouse TIS21 involved in suppression of CAF1 deadenylase activity.

PubMed ID: 18974182

DOI: 10.1093/nar/gkn825

Sequence Information:

  • Length: 158
  • Mass: 17416
  • Checksum: FFAA1844CC360209
  • Sequence:
    • MSHGKGTDML PEIAAAVGFL SSLLRTRGCV SEQRLKVFSG ALQEALTEHY KHHWFPEKPS 
KGSGYRCIRI NHKMDPIISR VASQIGLSQP QLHQLLPSEL TLWVDPYEVS YRIGEDGSIC 
VLYEEAPLAA SCGLLTCKNQ VLLGRSSPSK NYVMAVSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.