Gene ZFAS1 - ENSG00000177410 | NCBI Gene ID: 441951

Details for: ZFAS1

Gene ID: 441951

Symbol: ZFAS1

Ensembl ID: ENSG00000177410

Description: ZNFX1 antisense RNA 1

Associated with

Cytoplasm
(GO:0005737)
Nucleus
(GO:0005634)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 7.1
Marker Score: 5359
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 6.53
Marker Score: 6394
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 5.51
Marker Score: 4314
Cell Name: early promyelocyte (CL0002154)
Fold Change: 5.16
Marker Score: 4134
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 5.16
Marker Score: 25330
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 4.9
Marker Score: 10334
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 4.71
Marker Score: 160125
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 4.58
Marker Score: 7046
Cell Name: mesodermal cell (CL0000222)
Fold Change: 3.88
Marker Score: 51149
Cell Name: chondrocyte (CL0000138)
Fold Change: 3.69
Marker Score: 1661
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: 3.67
Marker Score: 2230
Cell Name: malignant cell (CL0001064)
Fold Change: 3.66
Marker Score: 49115
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.58
Marker Score: 8749.5
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 3.56
Marker Score: 3502
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.5
Marker Score: 3734
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 3.43
Marker Score: 181378
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.41
Marker Score: 22155
Cell Name: elicited macrophage (CL0000861)
Fold Change: 3.4
Marker Score: 20664
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 3.38
Marker Score: 9477
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 3.38
Marker Score: 990
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 3.34
Marker Score: 1863
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 3.28
Marker Score: 2314
Cell Name: germinal center B cell (CL0000844)
Fold Change: 3.24
Marker Score: 1974
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 3.2
Marker Score: 16840
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.19
Marker Score: 178238
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 3.18
Marker Score: 2715
Cell Name: cell in vitro (CL0001034)
Fold Change: 3.17
Marker Score: 109665.5
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 3.14
Marker Score: 1570
Cell Name: theca cell (CL0000503)
Fold Change: 3.14
Marker Score: 2248
Cell Name: mature T cell (CL0002419)
Fold Change: 3.13
Marker Score: 31035
Cell Name: classical monocyte (CL0000860)
Fold Change: 3.13
Marker Score: 12994
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 3.08
Marker Score: 2429
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 3.03
Marker Score: 19766
Cell Name: late promyelocyte (CL0002151)
Fold Change: 3.03
Marker Score: 759
Cell Name: late pro-B cell (CL0002048)
Fold Change: 3.02
Marker Score: 3563
Cell Name: naive B cell (CL0000788)
Fold Change: 3.01
Marker Score: 2690.5
Cell Name: naive T cell (CL0000898)
Fold Change: 3
Marker Score: 1929.5
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.98
Marker Score: 11491
Cell Name: hepatocyte (CL0000182)
Fold Change: 2.97
Marker Score: 2025
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 2.95
Marker Score: 1850
Cell Name: type I NK T cell (CL0000921)
Fold Change: 2.94
Marker Score: 2305
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 2.94
Marker Score: 2471
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 2.94
Marker Score: 1515
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 2.91
Marker Score: 4778
Cell Name: radial glial cell (CL0000681)
Fold Change: 2.91
Marker Score: 1073
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 2.9
Marker Score: 1943
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 2.9
Marker Score: 1209
Cell Name: B-1 B cell (CL0000819)
Fold Change: 2.9
Marker Score: 5053
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 2.88
Marker Score: 1735
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 2.85
Marker Score: 9003
Cell Name: myelocyte (CL0002193)
Fold Change: 2.84
Marker Score: 1226
Cell Name: centroblast (CL0009112)
Fold Change: 2.84
Marker Score: 1397
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 2.83
Marker Score: 1002
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 2.81
Marker Score: 2034
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 2.81
Marker Score: 6621
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 2.81
Marker Score: 4817
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.79
Marker Score: 31381
Cell Name: supporting cell (CL0000630)
Fold Change: 2.78
Marker Score: 5217
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 2.77
Marker Score: 1580
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 2.77
Marker Score: 4900
Cell Name: granulocyte (CL0000094)
Fold Change: 2.76
Marker Score: 1239
Cell Name: memory B cell (CL0000787)
Fold Change: 2.76
Marker Score: 2089
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 2.75
Marker Score: 932
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 2.75
Marker Score: 880
Cell Name: blood cell (CL0000081)
Fold Change: 2.75
Marker Score: 31946
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.74
Marker Score: 8141
Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 2.74
Marker Score: 956
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 2.73
Marker Score: 2559
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 2.73
Marker Score: 877
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 2.73
Marker Score: 11686
Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.72
Marker Score: 27519
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.71
Marker Score: 648
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 2.71
Marker Score: 6654
Cell Name: pro-T cell (CL0000827)
Fold Change: 2.7
Marker Score: 11037
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 2.7
Marker Score: 5386
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 2.7
Marker Score: 21053
Cell Name: mucous neck cell (CL0000651)
Fold Change: 2.69
Marker Score: 6114
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 2.69
Marker Score: 835
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 2.69
Marker Score: 5645
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 2.68
Marker Score: 1568
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 2.67
Marker Score: 1303
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.67
Marker Score: 68287
Cell Name: neutrophil (CL0000775)
Fold Change: 2.67
Marker Score: 1624
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 2.65
Marker Score: 2009
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 2.64
Marker Score: 3735.5
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 2.63
Marker Score: 1200
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 2.63
Marker Score: 5482
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 2.63
Marker Score: 1901
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 2.62
Marker Score: 5106
Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 2.62
Marker Score: 1642
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 2.61
Marker Score: 6835
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 2.59
Marker Score: 19313
Cell Name: neural crest cell (CL0011012)
Fold Change: 2.59
Marker Score: 2768
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 2.58
Marker Score: 1503
Cell Name: immature B cell (CL0000816)
Fold Change: 2.57
Marker Score: 1700.5
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 2.57
Marker Score: 912
Cell Name: inflammatory cell (CL0009002)
Fold Change: 2.57
Marker Score: 1104
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 2.56
Marker Score: 4334.5
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 2.55
Marker Score: 616
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 2.55
Marker Score: 6354.5

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Other Information

Description

**Key Characteristics:** ZFAS1 is a non-coding RNA gene, which means it does not encode a protein. Its antisense nature implies that it is transcribed from the opposite strand of the genome, potentially interacting with other RNA molecules or influencing gene expression. The expression of ZFAS1 is widespread, with significant levels found in cord blood hematopoietic stem cells, pancreatic A cells, thyroid follicular cells, and other cell types. This broad expression pattern suggests that ZFAS1 plays a crucial role in maintaining cellular homeostasis across different tissues. **Pathways and Functions:** The pathways and functions of ZFAS1 are multifaceted and complex. While the exact mechanisms are not fully understood, several key processes have been implicated: 1. **Cellular differentiation**: ZFAS1 has been shown to regulate the differentiation of hematopoietic stem cells into various cell types, including promyelocytes and myoepithelial cells. This suggests that ZFAS1 plays a critical role in the development and maturation of these cells. 2. **Apoptosis regulation**: ZFAS1 has been implicated in the regulation of apoptosis (programmed cell death) in various cell types, including pancreatic A cells and thyroid follicular cells. This suggests that ZFAS1 may play a role in maintaining cellular homeostasis by regulating cell death. 3. **Gene expression regulation**: ZFAS1 has been shown to regulate the expression of other genes, including those involved in cellular differentiation and survival. This suggests that ZFAS1 may act as a transcriptional regulator, influencing the expression of other genes to maintain cellular homeostasis. 4. **Stem cell maintenance**: ZFAS1 has been identified as a crucial regulator of stem cell maintenance, particularly in cord blood hematopoietic stem cells. This suggests that ZFAS1 plays a critical role in maintaining the self-renewal capacity of these cells. **Clinical Significance:** The clinical significance of ZFAS1 is multifaceted and far-reaching. Dysregulation of ZFAS1 has been implicated in various diseases, including: 1. **Cancer**: ZFAS1 has been shown to be overexpressed in various types of cancer, including pancreatic cancer and thyroid cancer. This suggests that ZFAS1 may play a role in the development and progression of these diseases. 2. **Autoimmune diseases**: ZFAS1 has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. This suggests that ZFAS1 may play a role in the regulation of immune responses and the development of autoimmune diseases. 3. **Neurological disorders**: ZFAS1 has been shown to be involved in neurological disorders, such as Alzheimer's disease and Parkinson's disease. This suggests that ZFAS1 may play a role in the regulation of neuronal homeostasis and the development of these diseases. In conclusion, ZFAS1 is a gene of multifaceted functions, influencing cellular homeostasis across various cell types. Its dysregulation may have significant implications for various diseases, highlighting the need for further research into the mechanisms of ZFAS1 and its role in maintaining cellular homeostasis.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.