PAK2 | ENSG00000180370 | NCBI 5062

Details for: PAK2

Gene ID: 5062

Symbol: PAK2

Ensembl ID: ENSG00000180370

Description: p21 (RAC1) activated kinase 2

Associated with

Activation of rac1
(R-HSA-428540)
Adaptive immune system
(R-HSA-1280218)
Apoptosis
(R-HSA-109581)
Apoptotic execution phase
(R-HSA-75153)
Axon guidance
(R-HSA-422475)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cd28 co-stimulation
(R-HSA-389356)
Cd28 dependent vav1 pathway
(R-HSA-389359)
Cd209 (dc-sign) signaling
(R-HSA-5621575)
Cdc42 gtpase cycle
(R-HSA-9013148)
Costimulation by the cd28 family
(R-HSA-388841)
Cytokine signaling in immune system
(R-HSA-1280215)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eph-ephrin signaling
(R-HSA-2682334)
Ephrin signaling
(R-HSA-3928664)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated mapk activation
(R-HSA-2871796)
Gene and protein expression by jak-stat signaling after interleukin-12 stimulation
(R-HSA-8950505)
Generation of second messenger molecules
(R-HSA-202433)
Hiv infection
(R-HSA-162906)
Host interactions of hiv factors
(R-HSA-162909)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-12 family signaling
(R-HSA-447115)
Interleukin-12 signaling
(R-HSA-9020591)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Muscle contraction
(R-HSA-397014)
Nef and signal transduction
(R-HSA-164944)
Nervous system development
(R-HSA-9675108)
Programmed cell death
(R-HSA-5357801)
Rac1 gtpase cycle
(R-HSA-9013149)
Rac2 gtpase cycle
(R-HSA-9013404)
Rac3 gtpase cycle
(R-HSA-9013423)
Regulation of activated pak-2p34 by proteasome mediated degradation
(R-HSA-211733)
Regulation of apoptosis
(R-HSA-169911)
Regulation of pak-2p34 activity by ps-gap/rhg10
(R-HSA-211728)
Rhog gtpase cycle
(R-HSA-9013408)
Rho gtpase cycle
(R-HSA-9012999)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate paks
(R-HSA-5627123)
Rhoh gtpase cycle
(R-HSA-9013407)
Rhoj gtpase cycle
(R-HSA-9013409)
Rhoq gtpase cycle
(R-HSA-9013406)
Rhou gtpase cycle
(R-HSA-9013420)
Rhov gtpase cycle
(R-HSA-9013424)
Sema3a pak dependent axon repulsion
(R-HSA-399954)
Semaphorin interactions
(R-HSA-373755)
Signaling by interleukins
(R-HSA-449147)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by robo receptors
(R-HSA-376176)
Signaling by vegf
(R-HSA-194138)
Smooth muscle contraction
(R-HSA-445355)
Stimulation of the cell death response by pak-2p34
(R-HSA-211736)
Tcr signaling
(R-HSA-202403)
The role of nef in hiv-1 replication and disease pathogenesis
(R-HSA-164952)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Vegfr2 mediated vascular permeability
(R-HSA-5218920)
Viral infection pathways
(R-HSA-9824446)
Adherens junction assembly
(GO:0034333)
Apoptotic process
(GO:0006915)
Atp binding
(GO:0005524)
Cadherin binding
(GO:0045296)
Cardiac muscle hypertrophy
(GO:0003300)
Cell migration
(GO:0016477)
Cellular response to starvation
(GO:0009267)
Chromatin remodeling
(GO:0006338)
Histone h2as1 kinase activity
(GO:0044024)
Identical protein binding
(GO:0042802)
Intracellular signal transduction
(GO:0035556)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of protein kinase activity
(GO:0006469)
Negative regulation of stress fiber assembly
(GO:0051497)
Peptidyl-serine phosphorylation
(GO:0018105)
Phosphorylation
(GO:0016310)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein kinase binding
(GO:0019901)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Protein tyrosine kinase activator activity
(GO:0030296)
Regulation of axonogenesis
(GO:0050770)
Regulation of cytoskeleton organization
(GO:0051493)
Regulation of mapk cascade
(GO:0043408)
Signal transduction
(GO:0007165)
Small gtpase binding
(GO:0031267)
Stimulatory c-type lectin receptor signaling pathway
(GO:0002223)
Vascular endothelial growth factor receptor signaling pathway
(GO:0048010)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 531.0353
Cell Significance Index: -82.6000
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 303.7730
Cell Significance Index: -77.0500
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 219.0570
Cell Significance Index: -90.2400
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 187.1336
Cell Significance Index: -88.3500
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 178.6553
Cell Significance Index: -72.5800
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 160.3079
Cell Significance Index: -82.4600
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 76.7851
Cell Significance Index: -73.3100
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 69.9052
Cell Significance Index: -86.1900
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 29.6693
Cell Significance Index: -79.4800
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 22.1031
Cell Significance Index: -87.2200
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 19.8438
Cell Significance Index: -43.4300
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 19.2189
Cell Significance Index: -59.0300
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.1334
Cell Significance Index: 39.4300
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.8324
Cell Significance Index: 225.3200
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.7921
Cell Significance Index: 355.6400
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.7100
Cell Significance Index: 110.3200
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.6353
Cell Significance Index: 294.8000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.1880
Cell Significance Index: 238.3200
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.1783
Cell Significance Index: 161.8200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.1628
Cell Significance Index: 31.0500
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.1114
Cell Significance Index: 32.6400
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.0879
Cell Significance Index: 594.1200
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 1.0842
Cell Significance Index: 66.6400
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.9899
Cell Significance Index: 51.5600
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.9393
Cell Significance Index: 336.9200
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.9295
Cell Significance Index: 71.3300
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.8982
Cell Significance Index: 105.9200
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.8197
Cell Significance Index: 46.0000
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.6291
Cell Significance Index: 278.1300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5489
Cell Significance Index: 15.8200
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.5334
Cell Significance Index: 25.0700
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.4972
Cell Significance Index: 343.8900
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.4530
Cell Significance Index: 12.6600
Cell Name: odontoblast (CL0000060)
Fold Change: 0.4326
Cell Significance Index: 55.4600
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.3641
Cell Significance Index: 9.9100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3009
Cell Significance Index: 6.5200
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2891
Cell Significance Index: 13.4800
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2657
Cell Significance Index: 28.9000
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.2091
Cell Significance Index: 14.7900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1637
Cell Significance Index: 7.4200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1542
Cell Significance Index: 290.3000
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.1388
Cell Significance Index: 3.9800
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0811
Cell Significance Index: 8.0300
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0511
Cell Significance Index: 9.7300
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0508
Cell Significance Index: 78.2400
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0501
Cell Significance Index: 1.7600
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0463
Cell Significance Index: 29.4300
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0455
Cell Significance Index: 83.9400
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.0281
Cell Significance Index: 0.1700
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0094
Cell Significance Index: 4.2500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0128
Cell Significance Index: -17.3600
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0203
Cell Significance Index: -3.4700
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0447
Cell Significance Index: -32.7800
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0641
Cell Significance Index: -47.5100
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0735
Cell Significance Index: -45.9100
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0852
Cell Significance Index: -64.5000
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1019
Cell Significance Index: -13.1600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1195
Cell Significance Index: -67.4100
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1228
Cell Significance Index: -12.5400
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1309
Cell Significance Index: -6.8000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1556
Cell Significance Index: -11.6000
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2627
Cell Significance Index: -75.6000
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2631
Cell Significance Index: -30.6600
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2922
Cell Significance Index: -42.4700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.3041
Cell Significance Index: -64.0500
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.3642
Cell Significance Index: -6.1400
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.4078
Cell Significance Index: -46.7300
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.4101
Cell Significance Index: -24.6200
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.4622
Cell Significance Index: -52.7600
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.5065
Cell Significance Index: -13.0200
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.5366
Cell Significance Index: -12.8700
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.6611
Cell Significance Index: -41.6700
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.6768
Cell Significance Index: -18.1100
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.6992
Cell Significance Index: -72.8000
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.7120
Cell Significance Index: -47.8800
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.8287
Cell Significance Index: -21.7900
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.8510
Cell Significance Index: -16.6100
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.8597
Cell Significance Index: -11.7300
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.8654
Cell Significance Index: -68.5400
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.9179
Cell Significance Index: -15.7300
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.9192
Cell Significance Index: -13.9600
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.9667
Cell Significance Index: -42.7600
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -1.0321
Cell Significance Index: -54.1900
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.0991
Cell Significance Index: -38.2000
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -1.1284
Cell Significance Index: -23.6200
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -1.1288
Cell Significance Index: -10.4000
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.1907
Cell Significance Index: -29.7700
Cell Name: peg cell (CL4033014)
Fold Change: -1.2154
Cell Significance Index: -28.0800
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -1.2169
Cell Significance Index: -46.0800
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -1.2189
Cell Significance Index: -20.4000
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -1.2290
Cell Significance Index: -18.1400
Cell Name: pro-T cell (CL0000827)
Fold Change: -1.3841
Cell Significance Index: -35.3600
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.4163
Cell Significance Index: -86.8300
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.4569
Cell Significance Index: -46.6600
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -1.5866
Cell Significance Index: -22.8200
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -1.6641
Cell Significance Index: -84.1000
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -1.7106
Cell Significance Index: -36.4300
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -1.7415
Cell Significance Index: -37.2300
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -1.7726
Cell Significance Index: -26.1700
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -1.9471
Cell Significance Index: -22.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Serine/threonine-protein kinase**: PAK2 belongs to the protein kinase family, catalyzing the phosphorylation of serine and threonine residues on target proteins. 2. **Rho GTPase regulator**: PAK2 interacts with Rho GTPases, modulating their activity and influencing downstream signaling cascades. 3. **Cell signaling**: PAK2 is involved in various signaling pathways, including those mediated by interleukins, receptor tyrosine kinases, and G-protein coupled receptors. 4. **Cytoskeleton organization**: PAK2 regulates cytoskeleton dynamics, affecting cell migration, adhesion, and morphology. 5. **Apoptosis**: PAK2 modulates apoptosis, either promoting or inhibiting cell death depending on the context and cellular environment. **Pathways and Functions** 1. **Adaptive immune system**: PAK2 is expressed in immune cells, such as T cells and dendritic cells, and regulates their activation, proliferation, and cytokine production. 2. **Innate immune system**: PAK2 is involved in the regulation of innate immune responses, including the activation of macrophages and neutrophils. 3. **Cell migration and adhesion**: PAK2 regulates cytoskeleton dynamics, influencing cell migration, adhesion, and the formation of adherens junctions. 4. **Apoptosis and programmed cell death**: PAK2 modulates apoptosis, either promoting or inhibiting cell death depending on the context and cellular environment. 5. **Vascular endothelial growth factor (VEGF) signaling**: PAK2 is involved in VEGF-mediated signaling, regulating angiogenesis and vascular permeability. **Clinical Significance** 1. **Immune-mediated diseases**: PAK2 dysregulation has been implicated in various immune-mediated diseases, including rheumatoid arthritis, multiple sclerosis, and autoimmune hemolytic anemia. 2. **Cancer**: PAK2 overexpression has been observed in several types of cancer, including breast, lung, and colon cancer, suggesting its potential as a prognostic biomarker or therapeutic target. 3. **Neurological disorders**: PAK2 has been implicated in the pathogenesis of neurological disorders, such as Parkinson's disease, Alzheimer's disease, and Huntington's disease. 4. **Vascular diseases**: PAK2 regulates vascular endothelial growth factor signaling, influencing angiogenesis and vascular permeability, which may contribute to the development of vascular diseases, such as atherosclerosis and hypertension. In conclusion, PAK2 is a multifunctional protein kinase that plays a crucial role in various cellular processes, including cell signaling, cytoskeleton organization, and apoptosis. Its dysregulation has been implicated in various diseases, highlighting its potential as a therapeutic target or prognostic biomarker.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Serine/threonine-protein kinase PAK 2
A8K5M4_HUMAN

Genular Protein ID: 2384880133

Symbol: PAK2_HUMAN

Name: Serine/threonine-protein kinase PAK 2

UniProtKB Accession Codes:

Q13177 Q13154 Q6ISC3

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7744004

Title: A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20.

PubMed ID: 7744004

DOI: 10.1002/j.1460-2075.1995.tb07189.x

PubMed ID: 7556080

Title:

PubMed ID: 7556080

DOI: 10.1002/j.1460-2075.1995.tb00113.x

PubMed ID: 7673144

Title: Activation of an S6/H4 kinase (PAK 65) from human placenta by intramolecular and intermolecular autophosphorylation.

PubMed ID: 7673144

DOI: 10.1074/jbc.270.36.21121

PubMed ID: 9171063

Title: Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2.

PubMed ID: 9171063

DOI: 10.1126/science.276.5318.1571

PubMed ID: 9786869

Title: Cleavage and activation of p21-activated protein kinase gamma-PAK by CPP32 (caspase 3). Effects of autophosphorylation on activity.

PubMed ID: 9786869

DOI: 10.1074/jbc.273.44.28733

PubMed ID: 11070003

Title: Lentivirus Nef specifically activates Pak2.

PubMed ID: 11070003

DOI: 10.1128/jvi.74.23.11081-11087.2000

PubMed ID: 12853446

Title: Caspase-activated PAK-2 is regulated by subcellular targeting and proteasomal degradation.

PubMed ID: 12853446

DOI: 10.1074/jbc.m306494200

PubMed ID: 15234964

Title: Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk.

PubMed ID: 15234964

DOI: 10.1074/jbc.m407337200

PubMed ID: 15471851

Title: Identification and characterization of PS-GAP as a novel regulator of caspase-activated PAK-2.

PubMed ID: 15471851

DOI: 10.1074/jbc.m410530200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16374509

Title: Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome.

PubMed ID: 16374509

DOI: 10.1038/sj.embor.7400596

PubMed ID: 16617111

Title: Posttranslational myristoylation of caspase-activated p21-activated protein kinase 2 (PAK2) potentiates late apoptotic events.

PubMed ID: 16617111

DOI: 10.1073/pnas.0600824103

PubMed ID: 18716323

Title: Scrib regulates PAK activity during the cell migration process.

PubMed ID: 18716323

DOI: 10.1093/hmg/ddn248

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19273597

Title: Dual role of Cdc42 in spindle orientation control of adherent cells.

PubMed ID: 19273597

DOI: 10.1128/mcb.01713-08

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20696164

Title: POSH2 is a RING finger E3 ligase with Rac1 binding activity through a partial CRIB domain.

PubMed ID: 20696164

DOI: 10.1016/j.febslet.2010.07.060

PubMed ID: 19923322

Title: Identification of MYO18A as a novel interacting partner of the PAK2/betaPIX/GIT1 complex and its potential function in modulating epithelial cell migration.

PubMed ID: 19923322

DOI: 10.1091/mbc.e09-03-0232

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21098037

Title: Mechanistic studies of the autoactivation of PAK2: a two-step model of cis initiation followed by trans amplification.

PubMed ID: 21098037

DOI: 10.1074/jbc.m110.156505

PubMed ID: 21317288

Title: Identification of the atypical MAPK Erk3 as a novel substrate for p21-activated kinase (Pak) activity.

PubMed ID: 21317288

DOI: 10.1074/jbc.m110.181743

PubMed ID: 21555521

Title: Phosphorylation of caspase-7 by p21-activated protein kinase (PAK) 2 inhibits chemotherapeutic drug-induced apoptosis of breast cancer cell lines.

PubMed ID: 21555521

DOI: 10.1074/jbc.m111.236596

PubMed ID: 21177766

Title: P21-activated protein kinase (PAK2)-mediated c-Jun phosphorylation at 5 threonine sites promotes cell transformation.

PubMed ID: 21177766

DOI: 10.1093/carcin/bgq271

PubMed ID: 21724829

Title: Phosphorylation of H4 Ser 47 promotes HIRA-mediated nucleosome assembly.

PubMed ID: 21724829

DOI: 10.1101/gad.2055511

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27889207

Title: Dual site phosphorylation of caspase-7 by PAK2 blocks apoptotic activity by two distinct mechanisms.

PubMed ID: 27889207

DOI: 10.1016/j.str.2016.11.001

PubMed ID: 21170023

Title: The assembly of a GTPase-kinase signalling complex by a bacterial catalytic scaffold.

PubMed ID: 21170023

DOI: 10.1038/nature09593

PubMed ID: 33693784

Title: Dominant monoallelic variant in the PAK2 gene causes Knobloch syndrome type 2.

PubMed ID: 33693784

DOI: 10.1093/hmg/ddab026

Sequence Information:

Length: 524
Mass: 58043
Checksum: 00A7CD15F93D4180
Sequence:

MSDNGELEDK PPAPPVRMSS TIFSTGGKDP LSANHSLKPL PSVPEEKKPR HKIISIFSGT 
EKGSKKKEKE RPEISPPSDF EHTIHVGFDA VTGEFTGMPE QWARLLQTSN ITKLEQKKNP 
QAVLDVLKFY DSNTVKQKYL SFTPPEKDGF PSGTPALNAK GTEAPAVVTE EEDDDEETAP 
PVIAPRPDHT KSIYTRSVID PVPAPVGDSH VDGAAKSLDK QKKKTKMTDE EIMEKLRTIV 
SIGDPKKKYT RYEKIGQGAS GTVFTATDVA LGQEVAIKQI NLQKQPKKEL IINEILVMKE 
LKNPNIVNFL DSYLVGDELF VVMEYLAGGS LTDVVTETCM DEAQIAAVCR ECLQALEFLH 
ANQVIHRDIK SDNVLLGMEG SVKLTDFGFC AQITPEQSKR STMVGTPYWM APEVVTRKAY 
GPKVDIWSLG IMAIEMVEGE PPYLNENPLR ALYLIATNGT PELQNPEKLS PIFRDFLNRC 
LEMDVEKRGS AKELLQHPFL KLAKPLSSLT PLIMAAKEAM KSNR

Genular Protein ID: 2005842726

Symbol: A8K5M4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K5M4

Database IDs:

Sequence Information:

Length: 524
Mass: 58044
Checksum: 8352E6C271F5EF84
Sequence:

MSDNGELEDK PPAPPVRMSS TIFSTGGKDP LSANHSLKPL PSVPEEKKPR HKIISIFSGT 
EKGSKKKEKE RPEISPPSDF EHTIHVGFDA VTGEFTGMPE QWARLLQTSD ITKLEQKKNP 
QAVLDVLKFY DSNTVKQKYL SFTPPEKDGF PSGTPALNAK GTEAPAVVTE EEDDDEETAP 
PVIAPRPDHT KSIYTRSVID PVPAPVGDSH VDGAAKSLDK QKKKTKMTDE EIMEKLRTIV 
SIGDPKKKYT RYEKIGQGAS GTVFTATDVA LGQEVAIKQI NLQKQPKKEL IINEILVMKE 
LKNPNIVNFL DSYLVGDELF VVMEYLAGGS LTDVVTETCM DEAQIAAVCR ECLQALEFLH 
ANQVIHRDIK SDNVLLGMEG SVKLTDFGFC AQITPEQSKR STMVGTPYWM APEVVTRKAY 
GPKVDIWSLG IMAIEMVEGE PPYLNENPLR ALYLIATNGT PELQNPEKLS PIFRDFLNRC 
LEMDVEKRGS AKELLQHPFL KLAKPLSSLT PLIMAAKEAM KSNR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PAK2

Associated with

Cells (max top 100)

Other Information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20. PubMed ID: 7744004

PubMed ID: 7556080

Activation of an S6/H4 kinase (PAK 65) from human placenta by intramolecular and intermolecular autophosphorylation. PubMed ID: 7673144

Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2. PubMed ID: 9171063

Cleavage and activation of p21-activated protein kinase gamma-PAK by CPP32 (caspase 3). Effects of autophosphorylation on activity. PubMed ID: 9786869

Lentivirus Nef specifically activates Pak2. PubMed ID: 11070003

Caspase-activated PAK-2 is regulated by subcellular targeting and proteasomal degradation. PubMed ID: 12853446

Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk. PubMed ID: 15234964

Identification and characterization of PS-GAP as a novel regulator of caspase-activated PAK-2. PubMed ID: 15471851

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome. PubMed ID: 16374509

Posttranslational myristoylation of caspase-activated p21-activated protein kinase 2 (PAK2) potentiates late apoptotic events. PubMed ID: 16617111

Scrib regulates PAK activity during the cell migration process. PubMed ID: 18716323

Phosphoproteome of resting human platelets. PubMed ID: 18088087

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Dual role of Cdc42 in spindle orientation control of adherent cells. PubMed ID: 19273597

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

POSH2 is a RING finger E3 ligase with Rac1 binding activity through a partial CRIB domain. PubMed ID: 20696164

Identification of MYO18A as a novel interacting partner of the PAK2/betaPIX/GIT1 complex and its potential function in modulating epithelial cell migration. PubMed ID: 19923322

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Mechanistic studies of the autoactivation of PAK2: a two-step model of cis initiation followed by trans amplification. PubMed ID: 21098037

Identification of the atypical MAPK Erk3 as a novel substrate for p21-activated kinase (Pak) activity. PubMed ID: 21317288

Phosphorylation of caspase-7 by p21-activated protein kinase (PAK) 2 inhibits chemotherapeutic drug-induced apoptosis of breast cancer cell lines. PubMed ID: 21555521

P21-activated protein kinase (PAK2)-mediated c-Jun phosphorylation at 5 threonine sites promotes cell transformation. PubMed ID: 21177766

Phosphorylation of H4 Ser 47 promotes HIRA-mediated nucleosome assembly. PubMed ID: 21724829

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Dual site phosphorylation of caspase-7 by PAK2 blocks apoptotic activity by two distinct mechanisms. PubMed ID: 27889207

The assembly of a GTPase-kinase signalling complex by a bacterial catalytic scaffold. PubMed ID: 21170023

Dominant monoallelic variant in the PAK2 gene causes Knobloch syndrome type 2. PubMed ID: 33693784