CNBP | ENSG00000169714 | NCBI 7555

Details for: CNBP

Gene ID: 7555

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: CNBP

Ensembl ID: ENSG00000169714

Description: CCHC-type zinc finger nucleic acid binding protein

Cell Significance Landscape

Display Count:

Associated with

Disease
(R-HSA-1643685)
Infectious disease
(R-HSA-5663205)
Sars-cov-2 activates/modulates innate and adaptive immune responses
(R-HSA-9705671)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Viral infection pathways
(R-HSA-9824446)
Cholesterol homeostasis
(GO:0042632)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endoplasmic reticulum
(GO:0005783)
G-quadruplex dna binding
(GO:0051880)
G-quadruplex dna formation
(GO:0071919)
Mrna binding
(GO:0003729)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleus
(GO:0005634)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cytoplasmic translation
(GO:2000767)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of dna-templated transcription
(GO:0006355)
Rna binding
(GO:0003723)
Single-stranded rna binding
(GO:0003727)
Translation regulator activity
(GO:0045182)
Zinc ion binding
(GO:0008270)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

hematopoietic stem cell CL0000037

CSI 121.42

rCSI 80.7%

PRS 7.09
megakaryocyte-erythroid progenitor cell CL0000050

CSI 98.92

rCSI 89.33%

PRS 5.25
keratinocyte CL0000312

CSI 97.92

rCSI 82.08%

PRS 7.13
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 92.03

rCSI 62%

PRS 7.18
common myeloid progenitor CL0000049

CSI 83.22

rCSI 67.29%

PRS 5.84
fallopian tube secretory epithelial cell CL4030006

CSI 79.66

rCSI 76.68%

PRS 6.17
granulocyte monocyte progenitor cell CL0000557

CSI 75.99

rCSI 65.8%

PRS 6.61
early lymphoid progenitor CL0000936

CSI 73.94

rCSI 64.94%

PRS 6.68
intestinal epithelial cell CL0002563

CSI 72.09

rCSI 75.35%

PRS 6.26
fraction A pre-pro B cell CL0002045

CSI 68.88

rCSI 78.85%

PRS 12.36
stem cell CL0000034

CSI 68.25

rCSI 65.8%

PRS 3.49
double-positive, alpha-beta thymocyte CL0000809

CSI 67.45

rCSI 68.74%

PRS 8.6
epithelial cell of lung CL0000082

CSI 64.04

rCSI 53.09%

PRS 5.68
pro-B cell CL0000826

CSI 62.84

rCSI 52.04%

PRS 5.96
common dendritic progenitor CL0001029

CSI 59.58

rCSI 74.77%

PRS 7.57
CD4-positive helper T cell CL0000492

CSI 58.61

rCSI 44.33%

PRS 8.29
colon epithelial cell CL0011108

CSI 57.37

rCSI 60.09%

PRS 5.53
mature B cell CL0000785

CSI 53.72

rCSI 46.7%

PRS 7.33
ciliated epithelial cell CL0000067

CSI 52.76

rCSI 46.4%

PRS 4.3
transit amplifying cell of colon CL0009011

CSI 48.16

rCSI 56.56%

PRS 7.13
neural crest cell CL0011012

CSI 47.05

rCSI 37.19%

PRS 4.11
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 46.44

rCSI 92.57%

PRS 10.19
extravillous trophoblast CL0008036

CSI 44.83

rCSI 55.46%

PRS 5.21
CD14-low, CD16-positive monocyte CL0002396

CSI 44.63

rCSI 34.39%

PRS 5.38
plasmablast CL0000980

CSI 44.51

rCSI 35.02%

PRS 7.08
promyelocyte CL0000836

CSI 42.95

rCSI 61.95%

PRS 8.3
pancreatic acinar cell CL0002064

CSI 42.35

rCSI 56.29%

PRS 6.47
OFF-bipolar cell CL0000750

CSI 41.71

rCSI 57.04%

PRS 10.38
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 37.88

rCSI 64.81%

PRS 12.87
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 37.03

rCSI 21.87%

PRS 8.26
memory B cell CL0000787

CSI 36.91

rCSI 36.45%

PRS 25.51
common lymphoid progenitor CL0000051

CSI 36.63

rCSI 48.95%

PRS 11.41
mesodermal cell CL0000222

CSI 36.43

rCSI 43.72%

PRS 5.91
enteric smooth muscle cell CL0002504

CSI 36.33

rCSI 51.84%

PRS 6.74
double negative thymocyte CL0002489

CSI 35.3

rCSI 24.54%

PRS 6.98
promonocyte CL0000559

CSI 35.22

rCSI 60.34%

PRS 7.98
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 34.73

rCSI 24.39%

PRS 17.31
retinal cone cell CL0000573

CSI 34.01

rCSI 54.74%

PRS 4.56
skin fibroblast CL0002620

CSI 33.65

rCSI 29.01%

PRS 9.87
epithelial cell of lower respiratory tract CL0002632

CSI 33.47

rCSI 25.95%

PRS 5.69
radial glial cell CL0000681

CSI 33.04

rCSI 45.9%

PRS 6.21
activated CD4-positive, alpha-beta T cell CL0000896

CSI 32.9

rCSI 30.42%

PRS 10.91
class switched memory B cell CL0000972

CSI 32.48

rCSI 24.25%

PRS 10.1
placental villous trophoblast CL2000060

CSI 32.02

rCSI 49.47%

PRS 5.59
stromal cell of ovary CL0002132

CSI 31.39

rCSI 86.25%

PRS 9.91
mucous neck cell CL0000651

CSI 30.79

rCSI 44.38%

PRS 9.66
group 3 innate lymphoid cell CL0001071

CSI 29.31

rCSI 22.02%

PRS 6.13
large pre-B-II cell CL0000957

CSI 29.18

rCSI 83.31%

PRS 10.59
bronchus fibroblast of lung CL2000093

CSI 28.89

rCSI 23.47%

PRS 6.38
microcirculation associated smooth muscle cell CL0008035

CSI 28.88

rCSI 83.62%

PRS 6.77
elicited macrophage CL0000861

CSI 28.48

rCSI 26.15%

PRS 6.83
T-helper 1 cell CL0000545

CSI 28.14

rCSI 50.8%

PRS 17.54
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 27.86

rCSI 33.76%

PRS 8.73
muscle cell CL0000187

CSI 27.82

rCSI 57.13%

PRS 14.45
T-helper 17 cell CL0000899

CSI 26.9

rCSI 21.36%

PRS 10.52
naive thymus-derived CD4-positive, alpha-beta T cell CL0000895

CSI 26.68

rCSI 33.53%

PRS 30.62
pancreatic A cell CL0000171

CSI 26.35

rCSI 27.61%

PRS 6.35
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 26.28

rCSI 17.51%

PRS 16.55
mucosal invariant T cell CL0000940

CSI 26

rCSI 21.01%

PRS 12.78
peripheral nervous system neuron CL2000032

CSI 25.56

rCSI 34.83%

PRS 5.35
forebrain radial glial cell CL0013000

CSI 24.16

rCSI 77.53%

PRS 8.94
colon goblet cell CL0009039

CSI 24.12

rCSI 57.35%

PRS 8.98
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 24.04

rCSI 32.75%

PRS 14.89
conjunctival epithelial cell CL1000432

CSI 23.96

rCSI 36.6%

PRS 5.97
pancreatic ductal cell CL0002079

CSI 23.36

rCSI 45.43%

PRS 6.07
basal-myoepithelial cell of mammary gland CL0002324

CSI 23.03

rCSI 43.53%

PRS 13.32
luminal epithelial cell of mammary gland CL0002326

CSI 22.85

rCSI 41.51%

PRS 9.1
mesenchymal cell CL0008019

CSI 22.2

rCSI 56.37%

PRS 6.09
kidney epithelial cell CL0002518

CSI 22.09

rCSI 42.16%

PRS 14.49
dendritic cell, human CL0001056

CSI 21.85

rCSI 33.56%

PRS 6.92
conventional dendritic cell CL0000990

CSI 21.78

rCSI 18.18%

PRS 19.26
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 21.32

rCSI 24.62%

PRS 5.37
naive B cell CL0000788

CSI 21.06

rCSI 18.07%

PRS 14.22
CD4-positive, alpha-beta memory T cell CL0000897

CSI 20.63

rCSI 14.81%

PRS 8.1
melanocyte CL0000148

CSI 20.6

rCSI 15.26%

PRS 5.48
basal cell of prostate epithelium CL0002341

CSI 20.54

rCSI 59.44%

PRS 13.54
transit amplifying cell CL0009010

CSI 20.41

rCSI 31.22%

PRS 9.74
mammary gland epithelial cell CL0002327

CSI 20.24

rCSI 71.01%

PRS 10.89
intestine goblet cell CL0019031

CSI 20.19

rCSI 17.92%

PRS 5.96
CD8-positive, alpha-beta memory T cell CL0000909

CSI 20.11

rCSI 21%

PRS 18.99
lymphoid lineage restricted progenitor cell CL0000838

CSI 19.83

rCSI 77.21%

PRS 9.85
glandular epithelial cell CL0000150

CSI 19.5

rCSI 51.34%

PRS 11.64
tendon cell CL0000388

CSI 19.42

rCSI 50.47%

PRS 18.19
late pro-B cell CL0002048

CSI 19.35

rCSI 48.48%

PRS 19.51
secretory cell CL0000151

CSI 19.27

rCSI 20.11%

PRS 6.1
pancreatic D cell CL0000173

CSI 19.2

rCSI 18.88%

PRS 6.47
immature B cell CL0000816

CSI 19.2

rCSI 14.26%

PRS 8.92
progenitor cell CL0011026

CSI 19.04

rCSI 40.49%

PRS 11.25
glioblast CL0000030

CSI 18.98

rCSI 30.28%

PRS 5.16
intestinal crypt stem cell of small intestine CL0009017

CSI 18.75

rCSI 50.54%

PRS 7.68
plasmacytoid dendritic cell, human CL0001058

CSI 18.52

rCSI 12.93%

PRS 6.26
alveolar type 1 fibroblast cell CL4028004

CSI 18.44

rCSI 20.2%

PRS 6.94
T follicular helper cell CL0002038

CSI 18.35

rCSI 13.73%

PRS 9.73
lung ciliated cell CL1000271

CSI 18.08

rCSI 20.9%

PRS 4.35
gamma-delta T cell CL0000798

CSI 18.07

rCSI 21.22%

PRS 49.58
CD1c-positive myeloid dendritic cell CL0002399

CSI 17.55

rCSI 21.2%

PRS 7.03
respiratory suprabasal cell CL4033048

CSI 17.51

rCSI 22.46%

PRS 6.87
keratocyte CL0002363

CSI 17.36

rCSI 41.74%

PRS 9.25
activated CD8-positive, alpha-beta T cell CL0000906

CSI 17.28

rCSI 16.99%

PRS 17.67
intrahepatic cholangiocyte CL0002538

CSI 17.22

rCSI 41.31%

PRS 11.24

renal interstitial pericyte CL1001318

CSI -17.6

rCSI -48.4%

PRS 6.5%
astrocyte of the cerebral cortex CL0002605

CSI -15.4

rCSI -34.4%

PRS 3.7%
lung interstitial macrophage CL4033043

CSI -11.3

rCSI -25.3%

PRS 14.6%
pulmonary capillary endothelial cell CL4028001

CSI -10.1

rCSI -19.3%

PRS 9.6%
platelet CL0000233

CSI -9.2

rCSI -38.2%

PRS 16.4%
vascular leptomeningeal cell CL4023051

CSI -7.9

rCSI -13.9%

PRS 4.5%
retinal bipolar neuron CL0000748

CSI -6.8

rCSI -12.8%

PRS 4.5%
near-projecting glutamatergic cortical neuron CL4023012

CSI -6.0

rCSI -22.8%

PRS 3.7%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI -6.0

rCSI -18.8%

PRS 4.1%
inhibitory interneuron CL0000498

CSI -5.9

rCSI -13.7%

PRS 5.2%
periportal region hepatocyte CL0019026

CSI -5.5

rCSI -21.2%

PRS 9.6%
Kupffer cell CL0000091

CSI -5.4

rCSI -12.4%

PRS 5.8%
fibroblast of cardiac tissue CL0002548

CSI -5.0

rCSI -23.9%

PRS 3.7%
neural cell CL0002319

CSI -4.9

rCSI -18.7%

PRS 11.4%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI -4.5

rCSI -16.1%

PRS 3.2%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI -3.9

rCSI -9.5%

PRS 3.4%
alpha-beta T cell CL0000789

CSI -3.8

rCSI -4.5%

PRS 9.2%
sncg GABAergic cortical interneuron CL4023015

CSI -3.6

rCSI -5.8%

PRS 3.9%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI -3.5

rCSI -20.4%

PRS 3.7%
endothelial cell of periportal hepatic sinusoid CL0019021

CSI -2.9

rCSI -13.5%

PRS 21.2%
immature innate lymphoid cell CL0001082

CSI -2.9

rCSI -89.1%

PRS 72.1%
exhausted T cell CL0011025

CSI -2.9

rCSI -48.5%

PRS 29.6%
sst GABAergic cortical interneuron CL4023017

CSI -2.8

rCSI -3.5%

PRS 3.7%
airway submucosal gland duct basal cell CL4033024

CSI -2.7

rCSI -17.6%

PRS 25.3%
pulmonary alveolar type 1 cell CL0002062

CSI -2.7

rCSI -15.6%

PRS 8.7%
hepatic pit cell CL2000054

CSI -2.6

rCSI -34.9%

PRS 49.6%
cardiac neuron CL0010022

CSI -2.5

rCSI -7.8%

PRS 4.5%
lamp5 GABAergic cortical interneuron CL4023011

CSI -2.0

rCSI -3.4%

PRS 3.5%
central nervous system neuron CL2000029

CSI -1.9

rCSI -13.9%

PRS 2.9%
pvalb GABAergic cortical interneuron CL4023018

CSI -1.9

rCSI -2.4%

PRS 3.2%
cord blood hematopoietic stem cell CL2000095

CSI -1.5

rCSI -28.0%

PRS 46.1%
cerebral cortex endothelial cell CL1001602

CSI -1.2

rCSI -2.0%

PRS 4.6%
inflammatory macrophage CL0000863

CSI -1.0

rCSI -1.7%

PRS 12.4%
H2 horizontal cell CL0004218

CSI -0.3

rCSI -1.6%

PRS 8.2%
cardiac endothelial cell CL0010008

CSI -0.3

rCSI -1.1%

PRS 6.2%
Cajal-Retzius cell CL0000695

CSI -0.1

rCSI -0.6%

PRS 13.8%
collagen secreting cell CL0000667

CSI 0.0

rCSI -0.2%

PRS 29.2%
L6b glutamatergic cortical neuron CL4023038

CSI 0.2

rCSI 0.6%

PRS 3.7%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 0.2

rCSI 0.4%

PRS 3.5%
direct pathway medium spiny neuron CL4023026

CSI 0.2

rCSI 5.7%

PRS 2.5%
endocardial cell CL0002350

CSI 0.3

rCSI 1.2%

PRS 9.3%
regular ventricular cardiac myocyte CL0002131

CSI 0.3

rCSI 1.6%

PRS 4.9%
indirect pathway medium spiny neuron CL4023029

CSI 0.3

rCSI 6.8%

PRS 3.3%
brush cell CL0002204

CSI 0.3

rCSI 0.6%

PRS 17.0%
parietal cell CL0000162

CSI 0.3

rCSI 2.6%

PRS 38.0%
Schwann cell CL0002573

CSI 0.3

rCSI 1.0%

PRS 7.8%
kidney connecting tubule epithelial cell CL1000768

CSI 0.3

rCSI 0.9%

PRS 4.7%
kidney loop of Henle epithelial cell CL1000909

CSI 0.4

rCSI 8.2%

PRS 46.4%
small intestine goblet cell CL1000495

CSI 0.4

rCSI 0.9%

PRS 8.1%
differentiation-committed oligodendrocyte precursor CL4023059

CSI 0.4

rCSI 0.7%

PRS 5.5%
neuroplacodal cell CL0000032

CSI 0.4

rCSI 3.6%

PRS 22.3%
activated CD4-positive, alpha-beta T cell, human CL0001043

CSI 0.5

rCSI 1.3%

PRS 39.6%
cytotoxic T cell CL0000910

CSI 0.6

rCSI 3.3%

PRS 9.1%
renal intercalated cell CL0005010

CSI 0.6

rCSI 5.3%

PRS 48.4%
uterine smooth muscle cell CL0002601

CSI 0.6

rCSI 3.9%

PRS 42.5%
endothelial cell of venule CL1000414

CSI 0.6

rCSI 5.6%

PRS 33.3%
endothelial cell of arteriole CL1000412

CSI 0.7

rCSI 4.0%

PRS 25.1%
Bergmann glial cell CL0000644

CSI 0.7

rCSI 1.0%

PRS 6.5%
myelocyte CL0002193

CSI 0.7

rCSI 4.9%

PRS 20.6%
midzonal region hepatocyte CL0019028

CSI 0.8

rCSI 1.8%

PRS 10.2%
osteoblast CL0000062

CSI 0.8

rCSI 19.7%

PRS 49.4%
renal principal cell CL0005009

CSI 0.8

rCSI 2.2%

PRS 8.6%
cerebral cortex neuron CL0010012

CSI 0.9

rCSI 3.7%

PRS 6.7%
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 1.0

rCSI 3.0%

PRS 11.4%
cone retinal bipolar cell CL0000752

CSI 1.0

rCSI 13.0%

PRS 32.2%
immature alpha-beta T cell CL0000790

CSI 1.0

rCSI 14.9%

PRS 66.9%
follicular dendritic cell CL0000442

CSI 1.1

rCSI 18.0%

PRS 37.1%
cerebellar granule cell CL0001031

CSI 1.2

rCSI 1.7%

PRS 5.9%
IgM plasma cell CL0000986

CSI 1.2

rCSI 5.3%

PRS 31.5%
slow muscle cell CL0000189

CSI 1.2

rCSI 16.3%

PRS 44.9%
colon macrophage CL0009038

CSI 1.2

rCSI 5.7%

PRS 13.0%
endothelial cell of vascular tree CL0002139

CSI 1.3

rCSI 6.9%

PRS 13.7%
stratified epithelial cell CL0000079

CSI 1.3

rCSI 7.9%

PRS 28.8%
adipocyte CL0000136

CSI 1.3

rCSI 1.7%

PRS 7.0%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 1.4

rCSI 3.6%

PRS 5.6%
antibody secreting cell CL0000946

CSI 1.4

rCSI 6.4%

PRS 26.8%
ventricular cardiac muscle cell CL2000046

CSI 1.5

rCSI 5.1%

PRS 26.1%
cardiac muscle cell CL0000746

CSI 1.5

rCSI 2.2%

PRS 4.8%
GABAergic neuron CL0000617

CSI 1.6

rCSI 5.2%

PRS 4.8%
paneth cell CL0000510

CSI 1.6

rCSI 2.3%

PRS 9.4%
eye photoreceptor cell CL0000287

CSI 1.7

rCSI 19.3%

PRS 19.5%
enterocyte of epithelium of small intestine CL1000334

CSI 1.8

rCSI 27.5%

PRS 15.3%
smooth muscle cell of the pulmonary artery CL0002591

CSI 1.9

rCSI 14.2%

PRS 31.3%
activated type II NK T cell CL0000931

CSI 1.9

rCSI 2.1%

PRS 9.8%
neural progenitor cell CL0011020

CSI 1.9

rCSI 8.5%

PRS 6.0%
epithelial cell of proximal tubule CL0002306

CSI 2.0

rCSI 4.8%

PRS 6.1%
duct epithelial cell CL0000068

CSI 2.0

rCSI 3.0%

PRS 6.3%
erythroblast CL0000765

CSI 2.1

rCSI 5.5%

PRS 10.1%
serous secreting cell CL0000313

CSI 2.1

rCSI 10.6%

PRS 28.7%
double negative T regulatory cell CL0011024

CSI 2.1

rCSI 40.6%

PRS 44.9%
deuterosomal cell CL4033044

CSI 2.2

rCSI 7.3%

PRS 10.2%
natural T-regulatory cell CL0000903

CSI 2.2

rCSI 4.1%

PRS 17.1%
mature alpha-beta T cell CL0000791

CSI 2.2

rCSI 7.9%

PRS 10.3%
tracheobronchial serous cell CL0019001

CSI 2.2

rCSI 9.6%

PRS 11.6%
colonocyte CL1000347

CSI 2.3

rCSI 3.3%

PRS 8.2%
epithelial cell of esophagus CL0002252

CSI 2.3

rCSI 22.6%

PRS 24.0%
B-1 B cell CL0000819

CSI 2.3

rCSI 59.6%

PRS 33.7%
lung microvascular endothelial cell CL2000016

CSI 2.4

rCSI 45.9%

PRS 21.3%
amacrine cell CL0000561

CSI 2.4

rCSI 6.9%

PRS 5.1%
type L enteroendocrine cell CL0002279

CSI 2.4

rCSI 4.6%

PRS 11.8%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary The CCHC-type zinc finger nucleic acid binding protein, encoded by the [CNBP](/details-gene/7555) gene, is a versatile regulator of gene expression with established roles in both transcription and translation. **Overall**, its expression profile indicates a fundamental role in cellular proliferation and differentiation, as it is a highly significant marker in various progenitor populations, including [hematopoietic stem cell](/details-cell/CL0000037) and [megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050), as well as in actively dividing epithelial tissues. Functionally, it binds to G-quadruplex DNA structures and G-rich elements in mRNA to modulate transcriptional and translational output ([Link](https://doi.org/10.1016/j.celrep.2017.02.080)). Clinically, intronic repeat expansions within the [CNBP](/details-gene/7555) gene are the cause of myotonic dystrophy type 2 ([116955](https://omim.org/entry/116955)), a multisystemic disorder ([Link](https://doi.org/10.1126/science.1062125)). ## Cellular Roles and Expression Landscape The expression landscape of [CNBP](/details-gene/7555) highlights its critical involvement in highly proliferative and developmental cellular contexts. **Overall**, it demonstrates high significance in a broad range of stem and progenitor cells, spanning both hematopoietic and lymphoid lineages. Key cell types include [hematopoietic stem cell](/details-cell/CL0000037) (CSI: 121.42), [megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050) (CSI: 98.92), [common myeloid progenitor](/details-cell/CL0000049) (CSI: 83.22), and [early lymphoid progenitor](/details-cell/CL0000936) (CSI: 73.94). This pattern extends to developing immune cells, such as [central memory CD8-positive, alpha-beta T cell](/details-cell/CL0000907) and [double-positive, alpha-beta thymocyte](/details-cell/CL0000809), suggesting a continuous role throughout hematopoiesis. Beyond the hematopoietic system, [CNBP](/details-gene/7555) is also a prominent marker in various epithelial tissues, with high significance in [keratinocyte](/details-cell/CL0000312), [fallopian tube secretory epithelial cell](/details-cell/CL4030006), and [intestinal epithelial cell](/details-cell/CL0002563). This broad expression in renewing tissues is consistent with a general function in maintaining cellular proliferation and tissue homeostasis. In stark contrast, [CNBP](/details-gene/7555) expression is notably low in terminally differentiated, post-mitotic cell populations. It is a significant anti-marker in diverse [neural cell](/details-cell/CL0002319) types, including [astrocyte of the cerebral cortex](/details-cell/CL0002605) (CSI: -15.36) and multiple neuronal subtypes. Furthermore, its low significance in cells like [pulmonary capillary endothelial cell](/details-cell/CL4028001) and [Kupffer cell](/details-cell/CL0000091) suggests a specialized function that is dispensable or downregulated in these mature, quiescent lineages. ## Pathways and Molecular Function [CNBP](/details-gene/7555) functions as a nucleic acid-binding protein with diverse regulatory activities. Its molecular functions are centered on its ability to bind various substrates, including [G-quadruplex dna binding](/details-go/GO:0051880), [mrna binding](/details-go/GO:0003729), and [single-stranded rna binding](/details-go/GO:0003727), facilitated by its zinc finger domains ([zinc ion binding](/details-go/GO:0008270)). This binding capability allows it to exert dual control over gene expression, participating in both [regulation of dna-templated transcription](/details-go/GO:0006355) and acting as a [translation regulator activity](/details-go/GO:0045182). At the biological process level, these molecular activities translate into a significant role in [positive regulation of cell population proliferation](/details-go/GO:0008284), which aligns perfectly with its high expression in stem and progenitor cells. Early research also identified its ability to bind sterol regulatory elements, linking it to [cholesterol homeostasis](/details-go/GO:0042632) ([Link](https://doi.org/10.1126/science.2562787)). Interestingly, pathway analysis strongly implicates [CNBP](/details-gene/7555) in the host response to viral infections, particularly [Sars-cov-2 infection](/details-pathway/R-HSA-9694516) and related pathways ([R-HSA-9705671](https://reactome.org/content/detail/R-HSA-9705671)). This suggests that its fundamental role in regulating cellular translation and transcription may be co-opted or modulated during viral pathogenesis. ## Research Directions The widespread significance of [CNBP](/details-gene/7555) in progenitor cells and its dual role in gene expression regulation present several avenues for future research. **Proposed Hypotheses:** 1. Given its high significance in hematopoietic precursors and its annotated function in [positive regulation of cell population proliferation](/details-go/GO:0008284), [CNBP](/details-gene/7555) likely functions as a master regulator of hematopoietic stem cell self-renewal and lineage commitment by controlling the translation of key mRNAs encoding cell cycle proteins and master transcription factors. 2. The strong enrichment for pathways related to [Sars-cov-2 infection](/details-pathway/R-HSA-9694516) and its high expression in [epithelial cell of lung](/details-cell/CL0000082) suggest that [CNBP](/details-gene/7555) may act as a critical host factor. It might be hijacked by the virus to enhance the translation of viral proteins or, alternatively, it may be part of an intrinsic host defense mechanism that regulates the expression of antiviral factors. **Experimental Approach:** To test the first hypothesis regarding the role of [CNBP](/details-gene/7555) in hematopoiesis, a conditional knockout mouse model using a Cre-Lox system to delete [CNBP](/details-gene/7555) specifically in the hematopoietic compartment (e.g., Vav-iCre) would be highly informative. Bone marrow from these mice could be analyzed using flow cytometry to assess changes in progenitor populations. *In vitro* colony-forming assays and competitive bone marrow transplantation experiments would directly test the self-renewal and differentiation capacity of [CNBP](/details-gene/7555)-deficient hematopoietic stem cells. Subsequently, techniques like RNA-immunoprecipitation followed by sequencing (RIP-seq) in isolated progenitor cells could identify the specific mRNA transcripts that [CNBP](/details-gene/7555) binds to and regulates. **Therapeutic Potential:** The therapeutic relevance of [CNBP](/details-gene/7555) is complex. In myotonic dystrophy type 2, the disease mechanism involves a toxic RNA gain-of-function from the intronic repeat expansion, rather than altered protein function, making the protein itself a difficult direct target for this condition ([Link](https://omim.org/entry/116955)). However, its critical role in cell proliferation suggests it could be a viable therapeutic target in malignancies characterized by uncontrolled growth. As such, **inhibition** of [CNBP](/details-gene/7555) function could be a strategy to curb cancer cell proliferation. A key challenge would be potential toxicity to healthy, highly proliferative tissues like hematopoietic progenitors and gut epithelium. Therefore, therapeutic strategies might require tumor-specific delivery mechanisms or could be most applicable in cancers where [CNBP](/details-gene/7555) is aberrantly overexpressed relative to essential normal tissues.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Zinc finger protein 9
A0A0S2Z4Q3_HUMAN

Genular Protein ID: 622875775

Symbol: CNBP_HUMAN

Name: Zinc finger protein 9

UniProtKB Accession Codes:

P62633 A8K7V4 B2RAV9 B4DP17 D3DNB9 D3DNC0 D3DNC1 E9PDR7 P20694 Q4JGY0 Q4JGY1 Q5QJR0 Q5U0E9 Q6PJI7 Q96NV3

Database IDs:

Citations:

PubMed ID: 2562787

Title: Identification of a zinc finger protein that binds to the sterol regulatory element.

PubMed ID: 2562787

DOI: 10.1126/science.2562787

PubMed ID: 7590281

Title: Organization of the gene encoding cellular nucleic acid-binding protein.

PubMed ID: 7590281

DOI: 10.1016/0378-1119(95)00421-2

PubMed ID: 11486088

Title: Myotonic dystrophy type 2 caused by a CCTG expansion in intron 1 of ZNF9.

PubMed ID: 11486088

DOI: 10.1126/science.1062125

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24726729

Title: Arginine methylation of the cellular nucleic acid binding protein does not affect its subcellular localization but impedes RNA binding.

PubMed ID: 24726729

DOI: 10.1016/j.febslet.2014.03.052

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28329689

Title: The Human CCHC-type Zinc Finger Nucleic Acid-Binding Protein Binds G-Rich Elements in Target mRNA Coding Sequences and Promotes Translation.

PubMed ID: 28329689

DOI: 10.1016/j.celrep.2017.02.080

Sequence Information:

Length: 177
Mass: 19463
Checksum: 996F398285F52618
Sequence:

MSSNECFKCG RSGHWARECP TGGGRGRGMR SRGRGGFTSD RGFQFVSSSL PDICYRCGES 
GHLAKDCDLQ EDACYNCGRG GHIAKDCKEP KREREQCCYN CGKPGHLARD CDHADEQKCY 
SCGEFGHIQK DCTKVKCYRC GETGHVAINC SKTSEVNCYR CGESGHLARE CTIEATA

Genular Protein ID: 2908733270

Symbol: A0A0S2Z4Q3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z4Q3

Database IDs:

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

Length: 170
Mass: 18742
Checksum: 152BEC42881358E8
Sequence:

MSSNECFKCG RSGHWARECP TGGGRGRGMR SRGRGFQFVS SSLPDICYRC GESGHLAKDC 
DLQEDACYNC GRGGHIAKDC KEPKREREQC CYNCGKPGHL ARDCDHADEQ KCYSCGEFGH 
IQKDCTKVKC YRCGETGHVA INCSKTSEVN CYRCGESGHL ARECTIEATA

Details for: CNBP

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Identification of a zinc finger protein that binds to the sterol regulatory element. PubMed ID: 2562787

Organization of the gene encoding cellular nucleic acid-binding protein. PubMed ID: 7590281

Myotonic dystrophy type 2 caused by a CCTG expansion in intron 1 of ZNF9. PubMed ID: 11486088

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Arginine methylation of the cellular nucleic acid binding protein does not affect its subcellular localization but impedes RNA binding. PubMed ID: 24726729

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

The Human CCHC-type Zinc Finger Nucleic Acid-Binding Protein Binds G-Rich Elements in Target mRNA Coding Sequences and Promotes Translation. PubMed ID: 28329689

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. PubMed ID: 26871637