Details for: CNBP

Gene ID: 7555

Symbol: CNBP

Ensembl ID: ENSG00000169714

Description: CCHC-type zinc finger nucleic acid binding protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 640.3925
    Cell Significance Index: -99.6100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 338.4279
    Cell Significance Index: -85.8400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 297.4893
    Cell Significance Index: -122.5500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 256.3211
    Cell Significance Index: -121.0200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 237.9005
    Cell Significance Index: -122.3700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 181.1118
    Cell Significance Index: -121.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 90.3033
    Cell Significance Index: -111.3400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 30.3620
    Cell Significance Index: -119.8100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 27.2802
    Cell Significance Index: -83.7900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.2885
    Cell Significance Index: -54.3500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 18.8980
    Cell Significance Index: -41.3600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 5.8396
    Cell Significance Index: 403.8400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.8703
    Cell Significance Index: 42.0800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.7832
    Cell Significance Index: 48.4500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.7352
    Cell Significance Index: 101.6700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.4211
    Cell Significance Index: 179.6200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.4198
    Cell Significance Index: 469.6300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.0801
    Cell Significance Index: 90.4600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.0301
    Cell Significance Index: 63.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.8427
    Cell Significance Index: 133.6100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.8023
    Cell Significance Index: 49.5200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.7390
    Cell Significance Index: 204.1300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.7377
    Cell Significance Index: 50.6000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.7189
    Cell Significance Index: 94.4800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.5777
    Cell Significance Index: 67.7800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.5283
    Cell Significance Index: 1117.8200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.4875
    Cell Significance Index: 318.8800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.3257
    Cell Significance Index: 164.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.3212
    Cell Significance Index: 299.8900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.3195
    Cell Significance Index: 66.4900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.3087
    Cell Significance Index: 375.4800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.2306
    Cell Significance Index: 143.9100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.2235
    Cell Significance Index: 273.4000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.1368
    Cell Significance Index: 385.2000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.8881
    Cell Significance Index: 1031.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.8219
    Cell Significance Index: 214.8600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.5003
    Cell Significance Index: 69.9500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.9693
    Cell Significance Index: 165.5200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9265
    Cell Significance Index: 24.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9132
    Cell Significance Index: 181.2400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.8670
    Cell Significance Index: 9.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8584
    Cell Significance Index: 172.2000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5816
    Cell Significance Index: 63.2600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5420
    Cell Significance Index: 489.3600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4736
    Cell Significance Index: 10.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3511
    Cell Significance Index: 125.9200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3019
    Cell Significance Index: 29.8600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3007
    Cell Significance Index: 7.7300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2640
    Cell Significance Index: 16.6400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2608
    Cell Significance Index: 7.5200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1625
    Cell Significance Index: 112.3900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1572
    Cell Significance Index: 118.9700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.1223
    Cell Significance Index: 2.9900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1084
    Cell Significance Index: 1.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0561
    Cell Significance Index: 105.7000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0043
    Cell Significance Index: 3.1500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0030
    Cell Significance Index: -0.5800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0220
    Cell Significance Index: -33.9400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0276
    Cell Significance Index: -50.8500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0329
    Cell Significance Index: -0.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0366
    Cell Significance Index: -3.7400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0456
    Cell Significance Index: -33.7500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0654
    Cell Significance Index: -40.8600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0666
    Cell Significance Index: -90.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0756
    Cell Significance Index: -5.8000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0766
    Cell Significance Index: -48.6300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1105
    Cell Significance Index: -5.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1136
    Cell Significance Index: -64.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1267
    Cell Significance Index: -57.5100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1704
    Cell Significance Index: -8.8500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2465
    Cell Significance Index: -51.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3203
    Cell Significance Index: -37.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3684
    Cell Significance Index: -106.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4895
    Cell Significance Index: -71.1500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5428
    Cell Significance Index: -61.9600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5805
    Cell Significance Index: -14.8300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6041
    Cell Significance Index: -16.1600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6849
    Cell Significance Index: -19.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.7143
    Cell Significance Index: -81.8400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.7515
    Cell Significance Index: -6.0000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.9383
    Cell Significance Index: -52.6500
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -1.0542
    Cell Significance Index: -17.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.0554
    Cell Significance Index: -64.8700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.0755
    Cell Significance Index: -111.9800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.0967
    Cell Significance Index: -86.8600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.1291
    Cell Significance Index: -15.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.1324
    Cell Significance Index: -76.1400
  • Cell Name: theca cell (CL0000503)
    Fold Change: -1.1438
    Cell Significance Index: -6.7200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -1.1560
    Cell Significance Index: -8.9100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.1744
    Cell Significance Index: -10.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.3213
    Cell Significance Index: -42.3200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.3241
    Cell Significance Index: -8.0000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.5218
    Cell Significance Index: -91.3600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.6779
    Cell Significance Index: -44.9600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.7196
    Cell Significance Index: -50.6500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.7405
    Cell Significance Index: -14.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.7957
    Cell Significance Index: -110.1000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.9756
    Cell Significance Index: -23.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.0842
    Cell Significance Index: -92.1900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.1442
    Cell Significance Index: -53.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Zinc finger protein structure**: CNBP contains a CCHC-type zinc finger domain, which is a type of DNA-binding motif that recognizes specific sequences of nucleic acids. 2. **Transcription regulation**: CNBP acts as a transcriptional regulator, influencing the expression of genes involved in immune responses, cell proliferation, and DNA-templated transcription. 3. **Immune cell regulation**: CNBP is highly expressed in immune cells, such as T cells, B cells, and hematopoietic stem cells, where it plays a critical role in modulating immune responses. 4. **Viral interaction**: CNBP has been shown to interact with SARS-CoV-2, influencing its ability to activate and modulate innate and adaptive immune responses. **Pathways and Functions** 1. **Transcriptional regulation**: CNBP interacts with RNA polymerase II to regulate the expression of genes involved in immune responses, cell proliferation, and DNA-templated transcription. 2. **Immune cell signaling**: CNBP modulates signaling pathways in immune cells, influencing their ability to recognize and respond to pathogens. 3. **Viral infection pathways**: CNBP interacts with SARS-CoV-2, influencing its ability to infect cells and modulate the host immune response. 4. **Cell proliferation**: CNBP regulates cell proliferation in muscle cells and other cell types, influencing tissue development and repair. **Clinical Significance** 1. **Viral infections**: CNBP's interaction with SARS-CoV-2 highlights its potential role in modulating the host immune response to viral infections. 2. **Immune-mediated diseases**: CNBP's involvement in immune cell regulation and transcriptional regulation may contribute to the development of immune-mediated diseases. 3. **Cancer research**: CNBP's role in regulating cell proliferation and DNA-templated transcription may have implications for cancer research and treatment. 4. **Neurological disorders**: CNBP's expression in the brain and its potential involvement in neurological disorders, such as Alzheimer's disease, warrant further investigation. In conclusion, CNBP is a critical protein involved in various cellular processes, including transcription regulation, immune cell regulation, and viral infection pathways. Its clinical significance lies in its potential role in modulating the host immune response to viral infections and its involvement in immune-mediated diseases, cancer, and neurological disorders. Further research is necessary to fully elucidate the functions and clinical significance of CNBP.

Genular Protein ID: 622875775

Symbol: CNBP_HUMAN

Name: Zinc finger protein 9

UniProtKB Accession Codes:

P62633 A8K7V4 B2RAV9 B4DP17 D3DNB9 D3DNC0 D3DNC1 E9PDR7 P20694 Q4JGY0 Q4JGY1 Q5QJR0 Q5U0E9 Q6PJI7 Q96NV3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CPTAC 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 22 Ensembl 7 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 7 Pumba 1 RNAct 1 Reactome 1 RefSeq 6 SASBDB 1 SIGNOR 1 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2562787

Title: Identification of a zinc finger protein that binds to the sterol regulatory element.

PubMed ID: 2562787

DOI: 10.1126/science.2562787

PubMed ID: 7590281

Title: Organization of the gene encoding cellular nucleic acid-binding protein.

PubMed ID: 7590281

DOI: 10.1016/0378-1119(95)00421-2

PubMed ID: 11486088

Title: Myotonic dystrophy type 2 caused by a CCTG expansion in intron 1 of ZNF9.

PubMed ID: 11486088

DOI: 10.1126/science.1062125

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24726729

Title: Arginine methylation of the cellular nucleic acid binding protein does not affect its subcellular localization but impedes RNA binding.

PubMed ID: 24726729

DOI: 10.1016/j.febslet.2014.03.052

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28329689

Title: The Human CCHC-type Zinc Finger Nucleic Acid-Binding Protein Binds G-Rich Elements in Target mRNA Coding Sequences and Promotes Translation.

PubMed ID: 28329689

DOI: 10.1016/j.celrep.2017.02.080

Sequence Information:

  • Length: 177
  • Mass: 19463
  • Checksum: 996F398285F52618
  • Sequence:
    • MSSNECFKCG RSGHWARECP TGGGRGRGMR SRGRGGFTSD RGFQFVSSSL PDICYRCGES 
GHLAKDCDLQ EDACYNCGRG GHIAKDCKEP KREREQCCYN CGKPGHLARD CDHADEQKCY 
SCGEFGHIQK DCTKVKCYRC GETGHVAINC SKTSEVNCYR CGESGHLARE CTIEATA

Genular Protein ID: 2908733270

Symbol: A0A0S2Z4Q3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z4Q3

Database IDs:

ARBA 8 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 6 Gene3D 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 Pfam 1 RefSeq 1 SMART 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 170
  • Mass: 18742
  • Checksum: 152BEC42881358E8
  • Sequence:
    • MSSNECFKCG RSGHWARECP TGGGRGRGMR SRGRGFQFVS SSLPDICYRC GESGHLAKDC 
DLQEDACYNC GRGGHIAKDC KEPKREREQC CYNCGKPGHL ARDCDHADEQ KCYSCGEFGH 
IQKDCTKVKC YRCGETGHVA INCSKTSEVN CYRCGESGHL ARECTIEATA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.