Details for: SRSF7

Gene ID: 6432

Symbol: SRSF7

Ensembl ID: ENSG00000115875

Description: serine and arginine rich splicing factor 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 563.9357
    Cell Significance Index: -87.7200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 341.0300
    Cell Significance Index: -86.5000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 281.0552
    Cell Significance Index: -115.7800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 263.3062
    Cell Significance Index: -106.9700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 242.9665
    Cell Significance Index: -114.7100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 229.6917
    Cell Significance Index: -118.1500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 171.6188
    Cell Significance Index: -115.1600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 112.8157
    Cell Significance Index: -107.7100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 86.4346
    Cell Significance Index: -106.5700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 28.4132
    Cell Significance Index: -112.1200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 27.2281
    Cell Significance Index: -83.6300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 26.0895
    Cell Significance Index: -69.8900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 20.0951
    Cell Significance Index: -43.9800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 4.9111
    Cell Significance Index: 629.5800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.4722
    Cell Significance Index: 128.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.7211
    Cell Significance Index: 174.8900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 3.5566
    Cell Significance Index: 123.5900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.0282
    Cell Significance Index: 63.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.8979
    Cell Significance Index: 397.9600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.8969
    Cell Significance Index: 315.0900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.8562
    Cell Significance Index: 184.2700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.6896
    Cell Significance Index: 73.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.6053
    Cell Significance Index: 307.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.5664
    Cell Significance Index: 315.5700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.5323
    Cell Significance Index: 27.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.2468
    Cell Significance Index: 405.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.1531
    Cell Significance Index: 951.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.1250
    Cell Significance Index: 1160.5300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.9767
    Cell Significance Index: 26.9700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.9572
    Cell Significance Index: 138.4200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.9033
    Cell Significance Index: 86.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7787
    Cell Significance Index: 352.9900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.7764
    Cell Significance Index: 46.7100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.6918
    Cell Significance Index: 19.2200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.6591
    Cell Significance Index: 44.3000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.5913
    Cell Significance Index: 44.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3986
    Cell Significance Index: 280.5600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.3594
    Cell Significance Index: 175.6300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1733
    Cell Significance Index: 25.4200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1697
    Cell Significance Index: 33.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.1657
    Cell Significance Index: 86.8800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.0266
    Cell Significance Index: 30.1500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.7168
    Cell Significance Index: 16.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5488
    Cell Significance Index: 30.8000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5040
    Cell Significance Index: 455.1000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4242
    Cell Significance Index: 152.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3968
    Cell Significance Index: 18.5000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.3531
    Cell Significance Index: 6.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2860
    Cell Significance Index: 181.6100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2145
    Cell Significance Index: 11.2600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2006
    Cell Significance Index: 138.7200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1227
    Cell Significance Index: 4.3100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1074
    Cell Significance Index: 1.2800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1059
    Cell Significance Index: 199.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1028
    Cell Significance Index: 158.2800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1012
    Cell Significance Index: 19.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0722
    Cell Significance Index: 133.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0689
    Cell Significance Index: 52.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0565
    Cell Significance Index: 9.6400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0328
    Cell Significance Index: 14.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0012
    Cell Significance Index: 0.0600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0033
    Cell Significance Index: -0.0500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0234
    Cell Significance Index: -17.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0309
    Cell Significance Index: -42.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0325
    Cell Significance Index: -2.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0627
    Cell Significance Index: -46.4300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0805
    Cell Significance Index: -50.2900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0821
    Cell Significance Index: -8.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1520
    Cell Significance Index: -85.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1537
    Cell Significance Index: -15.2000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.2152
    Cell Significance Index: -35.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2791
    Cell Significance Index: -58.7800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3303
    Cell Significance Index: -48.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3549
    Cell Significance Index: -102.1200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3611
    Cell Significance Index: -9.6600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3909
    Cell Significance Index: -27.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4495
    Cell Significance Index: -51.5000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5102
    Cell Significance Index: -58.2400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5883
    Cell Significance Index: -8.8200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5950
    Cell Significance Index: -15.2000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5971
    Cell Significance Index: -69.5800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6234
    Cell Significance Index: -47.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7462
    Cell Significance Index: -47.0300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.9257
    Cell Significance Index: -11.8600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.9515
    Cell Significance Index: -49.5600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.9839
    Cell Significance Index: -66.1600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.0153
    Cell Significance Index: -105.7200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.2105
    Cell Significance Index: -53.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.2715
    Cell Significance Index: -100.7000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.4968
    Cell Significance Index: -47.9400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.5393
    Cell Significance Index: -58.2900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.5846
    Cell Significance Index: -29.2900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.7174
    Cell Significance Index: -42.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.7772
    Cell Significance Index: -37.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.8756
    Cell Significance Index: -114.9900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.8863
    Cell Significance Index: -36.8200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.9724
    Cell Significance Index: -99.6800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -2.2462
    Cell Significance Index: -20.6900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.2890
    Cell Significance Index: -13.8300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -2.3160
    Cell Significance Index: -39.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Serine and Arginine Rich Motif:** SRSF7 possesses a distinctive serine and arginine-rich motif, which confers its ability to interact with RNA-binding proteins and facilitate alternative splicing. 2. **Spliceosome Complex:** SRSF7 is a key component of the spliceosome complex, which is responsible for the precise processing of pre-mRNA in eukaryotic cells. 3. **Alternative Splicing Regulation:** SRSF7 plays a critical role in regulating alternative splicing, a process that allows for the generation of diverse isoforms of proteins from a single gene. 4. **Immune Cell Specificity:** The expression of SRSF7 is highly restricted to specific cell types, including CD8-positive, alpha-beta memory T cells, activated CD8-positive, alpha-beta T cells, and erythroid progenitor cells. **Pathways and Functions:** SRSF7 is involved in various cellular processes, including: 1. **Gene Expression (Transcription):** SRSF7 regulates the expression of genes by controlling alternative splicing, which can lead to changes in protein function and cellular behavior. 2. **mRNA 3'-end Processing:** SRSF7 participates in the 3'-end processing of mRNA, which involves the addition of a poly-A tail to mature mRNA. 3. **mRNA Splicing:** SRSF7 is a key regulator of alternative splicing, which allows for the generation of diverse isoforms of proteins from a single gene. 4. **Negative Regulation of mRNA Splicing:** SRSF7 can also act as a negative regulator of mRNA splicing, preventing the inclusion of alternative exons in mature mRNA. **Clinical Significance:** Dysregulation of SRSF7 has been implicated in various diseases, including: 1. **Cancer:** Altered expression of SRSF7 has been observed in several types of cancer, including leukemia and lymphoma. 2. **Autoimmune Diseases:** SRSF7 has been implicated in the regulation of immune cell function, and dysregulation of SRSF7 may contribute to autoimmune diseases, such as rheumatoid arthritis. 3. **Immune Cell Dysfunction:** SRSF7 plays a critical role in regulating immune cell function, and alterations in SRSF7 expression may contribute to immune cell dysfunction and impaired immune responses. In conclusion, SRSF7 is a critical regulator of alternative splicing in immune cells, and its dysregulation has been implicated in various diseases. Further research is needed to fully elucidate the functional significance of SRSF7 in immune cell biology and to explore its potential as a therapeutic target.

Genular Protein ID: 1528048593

Symbol: SRSF7_HUMAN

Name: Serine/arginine-rich splicing factor 7

UniProtKB Accession Codes:

Q16629 B4DLU6 G5E9M3 Q564D3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRIDE 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 6 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 4 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8013463

Title: Characterization and cloning of the human splicing factor 9G8: a novel 35 kDa factor of the serine/arginine protein family.

PubMed ID: 8013463

DOI: 10.1002/j.1460-2075.1994.tb06554.x

PubMed ID: 7629084

Title: The gene encoding human splicing factor 9G8. Structure, chromosomal localization, and expression of alternatively processed transcripts.

PubMed ID: 7629084

DOI: 10.1074/jbc.270.30.17830

PubMed ID: 20857263

Title: Novel cis-active structures in the coding region mediate CRM1-dependent nuclear export of IFN-alpha 1 mRNA.

PubMed ID: 20857263

DOI: 10.1007/s00795-010-0492-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11336712

Title: Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA.

PubMed ID: 11336712

DOI: 10.1016/s1097-2765(01)00233-7

PubMed ID: 12501247

Title: CDK11 complexes promote pre-mRNA splicing.

PubMed ID: 12501247

DOI: 10.1074/jbc.m210057200

PubMed ID: 12667464

Title: SR splicing factors serve as adapter proteins for TAP-dependent mRNA export.

PubMed ID: 12667464

DOI: 10.1016/s1097-2765(03)00089-3

PubMed ID: 14684736

Title: Cyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cells.

PubMed ID: 14684736

DOI: 10.1074/jbc.m312895200

PubMed ID: 15169763

Title: Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization.

PubMed ID: 15169763

DOI: 10.1074/jbc.m403927200

PubMed ID: 15009664

Title: Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors.

PubMed ID: 15009664

DOI: 10.1046/j.1471-4159.2003.02232.x

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18364396

Title: Mutually exclusive interactions drive handover of mRNA from export adaptors to TAP.

PubMed ID: 18364396

DOI: 10.1073/pnas.0709167105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 17036044

Title: Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8.

PubMed ID: 17036044

DOI: 10.1038/sj.emboj.7601385

Sequence Information:

  • Length: 238
  • Mass: 27367
  • Checksum: 49136754D9630853
  • Sequence:
    • MSRYGRYGGE TKVYVGNLGT GAGKGELERA FSYYGPLRTV WIARNPPGFA FVEFEDPRDA 
EDAVRGLDGK VICGSRVRVE LSTGMPRRSR FDRPPARRPF DPNDRCYECG EKGHYAYDCH 
RYSRRRRSRS RSRSHSRSRG RRYSRSRSRS RGRRSRSASP RRSRSISLRR SRSASLRRSR 
SGSIKGSRYF QSPSRSRSRS RSISRPRSSR SKSRSPSPKR SRSPSGSPRR SASPERMD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.