Details for: IGFBP4

Gene ID: 3487

Symbol: IGFBP4

Ensembl ID: ENSG00000141753

Description: insulin like growth factor binding protein 4

Associated with

  • Metabolism of proteins
    (R-HSA-392499)
  • Post-translational protein modification
    (R-HSA-597592)
  • Post-translational protein phosphorylation
    (R-HSA-8957275)
  • Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
    (R-HSA-381426)
  • Endoplasmic reticulum lumen
    (GO:0005788)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Insulin-like growth factor i binding
    (GO:0031994)
  • Insulin-like growth factor ii binding
    (GO:0031995)
  • Mapk cascade
    (GO:0000165)
  • Negative regulation of canonical wnt signaling pathway
    (GO:0090090)
  • Positive regulation of insulin-like growth factor receptor signaling pathway
    (GO:0043568)
  • Positive regulation of mapk cascade
    (GO:0043410)
  • Protein binding
    (GO:0005515)
  • Regulation of cell growth
    (GO:0001558)
  • Regulation of glucose metabolic process
    (GO:0010906)
  • Regulation of insulin-like growth factor receptor signaling pathway
    (GO:0043567)
  • Response to organic cyclic compound
    (GO:0014070)
  • Signaling receptor binding
    (GO:0005102)
  • Signal transduction
    (GO:0007165)
  • Type b pancreatic cell proliferation
    (GO:0044342)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 4.57
    Marker Score: 2583
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 4.16
    Marker Score: 10576.5
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 3.95
    Marker Score: 11143
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.82
    Marker Score: 5529
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.6
    Marker Score: 23421
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.51
    Marker Score: 119272
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.12
    Marker Score: 2688
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.07
    Marker Score: 6123
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 3.05
    Marker Score: 4435.5
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.95
    Marker Score: 1226.5
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.92
    Marker Score: 5491
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.92
    Marker Score: 32864.5
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.91
    Marker Score: 12565
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.85
    Marker Score: 916
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.84
    Marker Score: 2424
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.79
    Marker Score: 3832
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.74
    Marker Score: 3563
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.57
    Marker Score: 598
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.55
    Marker Score: 6679
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.53
    Marker Score: 4281
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.51
    Marker Score: 2366
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 2.46
    Marker Score: 554
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.4
    Marker Score: 1236.5
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.35
    Marker Score: 6404
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.34
    Marker Score: 2489
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.33
    Marker Score: 1327
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.33
    Marker Score: 579
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.31
    Marker Score: 579
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.19
    Marker Score: 567
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.15
    Marker Score: 1186
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 2.12
    Marker Score: 514
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.11
    Marker Score: 21215.5
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 2.1
    Marker Score: 1324
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 2.07
    Marker Score: 1999
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 2.06
    Marker Score: 524
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.03
    Marker Score: 1939
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 2.03
    Marker Score: 432
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.97
    Marker Score: 454
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.94
    Marker Score: 735.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.94
    Marker Score: 6880.5
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.93
    Marker Score: 1045
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.91
    Marker Score: 7370
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.9
    Marker Score: 789
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.88
    Marker Score: 731
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.88
    Marker Score: 2020
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.86
    Marker Score: 1684
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.86
    Marker Score: 2299
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.86
    Marker Score: 1872
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.85
    Marker Score: 9941
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.82
    Marker Score: 4287
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.78
    Marker Score: 1266
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.75
    Marker Score: 10376
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 1.73
    Marker Score: 439
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.71
    Marker Score: 22511
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.68
    Marker Score: 8231.5
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.67
    Marker Score: 7228
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.66
    Marker Score: 2451
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.65
    Marker Score: 397
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.65
    Marker Score: 1777.5
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.65
    Marker Score: 361
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.63
    Marker Score: 1074
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.62
    Marker Score: 1009
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.61
    Marker Score: 2594
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.61
    Marker Score: 10370
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.6
    Marker Score: 452
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.59
    Marker Score: 1425
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.58
    Marker Score: 3049
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.55
    Marker Score: 384
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.55
    Marker Score: 11542
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.53
    Marker Score: 2357
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.53
    Marker Score: 1634
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.51
    Marker Score: 3681
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.48
    Marker Score: 986
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.48
    Marker Score: 1060
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.48
    Marker Score: 51228
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.46
    Marker Score: 1298
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.43
    Marker Score: 333
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.43
    Marker Score: 344
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.38
    Marker Score: 3256
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.38
    Marker Score: 593
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.37
    Marker Score: 435
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.37
    Marker Score: 7182
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.35
    Marker Score: 8832
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.33
    Marker Score: 459
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.33
    Marker Score: 471
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.32
    Marker Score: 642
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.31
    Marker Score: 20961
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.3
    Marker Score: 761
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.29
    Marker Score: 2444
  • Cell Name: adipose microvascular endothelial cell (CL2000072)
    Fold Change: 1.28
    Marker Score: 381
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.28
    Marker Score: 3149
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.27
    Marker Score: 2020
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 1.26
    Marker Score: 334
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.26
    Marker Score: 476
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.26
    Marker Score: 4131.5
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.25
    Marker Score: 985
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.24
    Marker Score: 1458
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.22
    Marker Score: 488
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.21
    Marker Score: 333
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.19
    Marker Score: 1373

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * The IGFBP4 gene is located on chromosome 17q25.1. * It is a large gene with a molecular weight of approximately 4.5 kb. * The protein is a transmembrane protein with a single IgV domain and a cytoplasmic domain. * It is a key regulator of cell growth and metabolism. **Pathways and functions:** * IGFBP4 is a ligand for the IGF-R. * It plays a role in regulating the expression of genes involved in cell growth, differentiation, and metabolism. * It is involved in the regulation of vascular development, tumor growth, and metastasis. * It is also involved in the regulation of inflammation and fibrosis. **Clinical significance:** * Mutations in the IGFBP4 gene have been linked to a number of human diseases, including cancer, cardiovascular disease, and diabetes. * Studies of IGFBP4 have led to the development of new diagnostic and therapeutic strategies for these diseases. **Additional information:** * The protein is also known as IGFBP-4, IGFB4, and CD115. * It is a highly conserved protein, with a similar sequence in mice and humans. * It is a well-studied protein that has been extensively characterized in model systems.

Genular Protein ID: 2807296251

Symbol: IBP4_HUMAN

Name: Insulin-like growth factor-binding protein 4

UniProtKB Accession Codes:

P22692 A0N9W2 B4E351 Q5U012 Q9UCL6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 11 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 4 PIR 1 PRINTS 2 PRO 1 PROSITE 4 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1704481

Title: Molecular cloning of the cDNAs encoding a novel insulin-like growth factor-binding protein from rat and human.

PubMed ID: 1704481

DOI: 10.1210/mend-4-10-1451

PubMed ID: 1707125

Title: Inhibitory insulin-like growth factor-binding protein: cloning, complete sequence, and physiological regulation.

PubMed ID: 1707125

DOI: 10.1210/mend-4-12-1806

PubMed ID: 1709161

Title: Identification and molecular cloning of two new 30-kDa insulin-like growth factor binding proteins isolated from adult human serum.

PubMed ID: 1709161

DOI: 10.1016/s0021-9258(18)31549-7

PubMed ID: 9048882

Title: Structural and functional analysis of the 5'-flanking region of the human insulin-like growth factor binding protein (IGFBP)-4 gene.

PubMed ID: 9048882

DOI: 10.1016/s0167-4781(96)00220-5

PubMed ID: 9615225

Title: Structure and transcription regulation of the human insulin-like growth factor binding protein 4 gene (IGFBP4).

PubMed ID: 9615225

DOI: 10.1006/geno.1998.5283

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1709585

Title: Purification of a colon cancer cell growth inhibitor and its identification as an insulin-like growth factor binding protein.

PubMed ID: 1709585

PubMed ID: 1726835

Title: Evidence that the inhibition of TE85 human bone cell proliferation by agents which stimulate cAMP production may in part be mediated by changes in the IGF-II regulatory system.

PubMed ID: 1726835

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 15642270

Title: Structural basis for the regulation of insulin-like growth factors by IGF binding proteins.

PubMed ID: 15642270

DOI: 10.1016/j.str.2004.11.009

PubMed ID: 16924115

Title: Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins.

PubMed ID: 16924115

DOI: 10.1073/pnas.0605652103

Sequence Information:

  • Length: 258
  • Mass: 27934
  • Checksum: 5E8F4638D99F0A94
  • Sequence:
    • MLPLCLVAAL LLAAGPGPSL GDEAIHCPPC SEEKLARCRP PVGCEELVRE PGCGCCATCA 
LGLGMPCGVY TPRCGSGLRC YPPRGVEKPL HTLMHGQGVC MELAEIEAIQ ESLQPSDKDE 
GDHPNNSFSP CSAHDRRCLQ KHFAKIRDRS TSGGKMKVNG APREDARPVP QGSCQSELHR 
ALERLAASQS RTHEDLYIIP IPNCDRNGNF HPKQCHPALD GQRGKCWCVD RKTGVKLPGG 
LEPKGELDCH QLADSFRE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.