Details for: NDUFS5

Gene ID: 4725

Symbol: NDUFS5

Ensembl ID: ENSG00000168653

Description: NADH:ubiquinone oxidoreductase subunit S5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 656.9150
    Cell Significance Index: -102.1800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 387.4337
    Cell Significance Index: -98.2700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 321.2302
    Cell Significance Index: -132.3300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 286.4073
    Cell Significance Index: -116.3600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 268.7649
    Cell Significance Index: -126.8900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 247.2272
    Cell Significance Index: -127.1700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 190.0682
    Cell Significance Index: -127.5400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 99.3061
    Cell Significance Index: -122.4400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 33.2343
    Cell Significance Index: -89.0300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 33.0837
    Cell Significance Index: -130.5500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 27.6351
    Cell Significance Index: -84.8800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 17.4816
    Cell Significance Index: -38.2600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 5.3946
    Cell Significance Index: 141.8500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 4.9126
    Cell Significance Index: 131.4100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 4.8378
    Cell Significance Index: 111.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.3908
    Cell Significance Index: 204.7200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.2154
    Cell Significance Index: 114.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 4.0660
    Cell Significance Index: 2220.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 4.0463
    Cell Significance Index: 190.1700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.9247
    Cell Significance Index: 206.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.9044
    Cell Significance Index: 480.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.8651
    Cell Significance Index: 696.7600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.7399
    Cell Significance Index: 34.4400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 3.6402
    Cell Significance Index: 257.4500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 3.6217
    Cell Significance Index: 1601.2500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.5265
    Cell Significance Index: 455.6000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.3614
    Cell Significance Index: 70.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.0936
    Cell Significance Index: 424.8400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.8230
    Cell Significance Index: 30.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.7813
    Cell Significance Index: 207.2900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.4902
    Cell Significance Index: 160.6600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.3879
    Cell Significance Index: 68.4500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.2601
    Cell Significance Index: 28.9500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.1575
    Cell Significance Index: 276.5900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.1102
    Cell Significance Index: 73.3300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.0910
    Cell Significance Index: 61.4100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.8380
    Cell Significance Index: 14.6800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.7807
    Cell Significance Index: 20.2300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.5653
    Cell Significance Index: 184.6000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4588
    Cell Significance Index: 75.7800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.2263
    Cell Significance Index: 21.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0270
    Cell Significance Index: 29.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.0013
    Cell Significance Index: 288.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.8520
    Cell Significance Index: 145.4800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5996
    Cell Significance Index: 16.0100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5399
    Cell Significance Index: 487.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5129
    Cell Significance Index: 102.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4711
    Cell Significance Index: 46.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4676
    Cell Significance Index: 92.8100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.4287
    Cell Significance Index: 324.5000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3166
    Cell Significance Index: 14.3500
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.2933
    Cell Significance Index: 2.5200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2739
    Cell Significance Index: 52.1200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2586
    Cell Significance Index: 189.6200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1890
    Cell Significance Index: 30.7400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1353
    Cell Significance Index: 2.5000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0962
    Cell Significance Index: 1.6100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0285
    Cell Significance Index: 0.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0224
    Cell Significance Index: 8.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0069
    Cell Significance Index: -5.1200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0102
    Cell Significance Index: -0.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0278
    Cell Significance Index: -2.8400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0334
    Cell Significance Index: -62.8700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0647
    Cell Significance Index: -40.3900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0707
    Cell Significance Index: -130.3100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0833
    Cell Significance Index: -128.2900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0970
    Cell Significance Index: -131.8900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1358
    Cell Significance Index: -76.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1446
    Cell Significance Index: -91.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2183
    Cell Significance Index: -99.0600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2327
    Cell Significance Index: -49.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2846
    Cell Significance Index: -32.6100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.3077
    Cell Significance Index: -18.4700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4341
    Cell Significance Index: -26.6800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4775
    Cell Significance Index: -37.8200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.5621
    Cell Significance Index: -19.7500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5684
    Cell Significance Index: -15.8900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6001
    Cell Significance Index: -68.5000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6931
    Cell Significance Index: -80.7700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7028
    Cell Significance Index: -22.5100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7089
    Cell Significance Index: -18.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.7113
    Cell Significance Index: -103.3900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.9013
    Cell Significance Index: -13.5100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.9799
    Cell Significance Index: -21.2300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -1.0042
    Cell Significance Index: -6.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.0199
    Cell Significance Index: -78.2700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.2347
    Cell Significance Index: -128.5600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.3868
    Cell Significance Index: -34.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.4343
    Cell Significance Index: -96.4500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.4723
    Cell Significance Index: -101.8200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.5090
    Cell Significance Index: -84.6800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.6073
    Cell Significance Index: -21.9300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.8924
    Cell Significance Index: -116.0200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -2.0268
    Cell Significance Index: -17.0300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -2.2249
    Cell Significance Index: -115.8900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -2.2391
    Cell Significance Index: -38.6000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.2588
    Cell Significance Index: -66.5300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -2.2746
    Cell Significance Index: -38.9800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -2.5775
    Cell Significance Index: -69.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.6786
    Cell Significance Index: -118.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit of Complex I**: NDUFS5 is a subunit of Complex I, the first enzyme in the respiratory electron transport chain. 2. **Iron-sulfur protein**: It is an iron-sulfur protein, essential for the catalytic activity of Complex I. 3. **Mitochondrial localization**: NDUFS5 is localized to the mitochondrial intermembrane space and inner membrane. 4. **High expression levels**: NDUFS5 is highly expressed in various cell types, including mesenchymal stem cells, renal intercalated cells, and mature T cells. **Pathways and Functions:** 1. **Aerobic respiration**: NDUFS5 is essential for the electron transport chain, which generates energy through the transfer of electrons from NADH to ubiquinone. 2. **Mitochondrial electron transport**: NDUFS5 participates in the mitochondrial electron transport chain, contributing to the production of the proton motive force. 3. **ATP synthesis**: The proton motive force generated by Complex I drives ATP synthesis through chemiosmotic coupling. 4. **Heat production**: NDUFS5 is involved in the production of heat by uncoupling proteins, which can have implications for thermoregulation. **Clinical Significance:** 1. **Neurodegenerative disorders**: Mutations in NDUFS5 have been linked to neurodegenerative diseases, such as Parkinson's disease, Alzheimer's disease, and Huntington's disease. 2. **Metabolic disorders**: Dysregulation of NDUFS5 has been implicated in metabolic disorders, including diabetes and obesity. 3. **Cancer**: NDUFS5 has been shown to be overexpressed in various types of cancer, including breast cancer and prostate cancer. 4. **Immunological research**: NDUFS5 has been identified as a potential target for immunotherapeutic interventions, particularly in the context of cancer immunotherapy. In conclusion, NDUFS5 plays a critical role in mitochondrial function and has significant implications for various diseases. Further research on NDUFS5 and its dysregulation is crucial for understanding the underlying mechanisms of disease and developing novel therapeutic strategies. As an immunologist, it is essential to consider the potential applications of NDUFS5 in immunological research, particularly in the context of cancer immunotherapy.

Genular Protein ID: 1983753075

Symbol: NDUS5_HUMAN

Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

UniProtKB Accession Codes:

O43920

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9653160

Title: Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning.

PubMed ID: 9653160

DOI: 10.1073/pnas.95.14.8175

PubMed ID: 10070614

Title: The human NADH:ubiquinone oxidoreductase NDUFS5 (15 kDa) subunit: cDNA cloning, chromosomal localization, tissue distribution and the absence of mutations in isolated complex I-deficient patients.

PubMed ID: 10070614

DOI: 10.1023/a:1005434912463

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12611891

Title: The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.

PubMed ID: 12611891

DOI: 10.1074/jbc.c300064200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21310150

Title: NDUFB7 and NDUFA8 are located at the intermembrane surface of complex I.

PubMed ID: 21310150

DOI: 10.1016/j.febslet.2011.01.046

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27626371

Title: Accessory subunits are integral for assembly and function of human mitochondrial complex I.

PubMed ID: 27626371

DOI: 10.1038/nature19754

PubMed ID: 20818383

Title: High-throughput, pooled sequencing identifies mutations in NUBPL and FOXRED1 in human complex I deficiency.

PubMed ID: 20818383

DOI: 10.1038/ng.659

Sequence Information:

  • Length: 106
  • Mass: 12518
  • Checksum: 3D55402837DD99EE
  • Sequence:
    • MPFLDIQKRF GLNIDRWLTI QSGEQPYKMA GRCHAFEKEW IECAHGIGYT RAEKECKIEY 
DDFVECLLRQ KTMRRAGTIR KQRDKLIKEG KYTPPPHHIG KGEPRP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.