Details for: NDUFS5

Gene ID: 4725

Symbol: NDUFS5

Ensembl ID: ENSG00000168653

Description: NADH:ubiquinone oxidoreductase subunit S5

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 4.21
    Marker Score: 6481
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 4.13
    Marker Score: 2202
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.81
    Marker Score: 37736
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 3.58
    Marker Score: 1318.5
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.55
    Marker Score: 3698.5
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.49
    Marker Score: 3727
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.48
    Marker Score: 45921
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.44
    Marker Score: 116973
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.37
    Marker Score: 8224
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.36
    Marker Score: 9015
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 3.34
    Marker Score: 4346
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.31
    Marker Score: 2594
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.3
    Marker Score: 5466
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.3
    Marker Score: 2810
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.29
    Marker Score: 17301
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.27
    Marker Score: 11609
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.27
    Marker Score: 1076
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.23
    Marker Score: 6074
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.21
    Marker Score: 111155
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.16
    Marker Score: 20524
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.15
    Marker Score: 36564
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.14
    Marker Score: 3790
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.12
    Marker Score: 7878
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 3.12
    Marker Score: 1296
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 3.11
    Marker Score: 2345
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.08
    Marker Score: 2746
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 3.08
    Marker Score: 18250
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 3.07
    Marker Score: 5037
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 3.07
    Marker Score: 5601
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.05
    Marker Score: 2876
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 3.05
    Marker Score: 2167
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.04
    Marker Score: 4839
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 3.04
    Marker Score: 971
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.02
    Marker Score: 23617.5
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3
    Marker Score: 8297
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.98
    Marker Score: 19419
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 2.97
    Marker Score: 1990
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.96
    Marker Score: 1183
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.92
    Marker Score: 154566
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.88
    Marker Score: 6568
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.88
    Marker Score: 21446
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.87
    Marker Score: 160425
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.86
    Marker Score: 683
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.84
    Marker Score: 1181
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.84
    Marker Score: 18093
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.83
    Marker Score: 10922
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.83
    Marker Score: 5055
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.83
    Marker Score: 1860
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.82
    Marker Score: 2865
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.81
    Marker Score: 1263
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.8
    Marker Score: 31545
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.78
    Marker Score: 4476
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.78
    Marker Score: 6312
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.76
    Marker Score: 1731
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.75
    Marker Score: 3896
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.75
    Marker Score: 27676
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.74
    Marker Score: 23796
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.73
    Marker Score: 13112.5
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.73
    Marker Score: 1598
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.72
    Marker Score: 11735
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.72
    Marker Score: 2882
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.71
    Marker Score: 2133
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.7
    Marker Score: 3339
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.7
    Marker Score: 69268
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.69
    Marker Score: 927
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.69
    Marker Score: 1384
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.68
    Marker Score: 7024
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.68
    Marker Score: 3797
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.68
    Marker Score: 5442
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.67
    Marker Score: 2098
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.67
    Marker Score: 23007
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.67
    Marker Score: 3444
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.67
    Marker Score: 2993
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.66
    Marker Score: 5322
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.66
    Marker Score: 5561
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.66
    Marker Score: 1330
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.66
    Marker Score: 2241
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.66
    Marker Score: 3652
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.63
    Marker Score: 1498
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.62
    Marker Score: 3000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.62
    Marker Score: 7347
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.62
    Marker Score: 1356
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.62
    Marker Score: 11223
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 2.62
    Marker Score: 693
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.61
    Marker Score: 3051
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.61
    Marker Score: 2504
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.6
    Marker Score: 6110
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.59
    Marker Score: 1230
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.59
    Marker Score: 831
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.58
    Marker Score: 7022
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.57
    Marker Score: 8067
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 2.56
    Marker Score: 1646
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.55
    Marker Score: 2389
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.55
    Marker Score: 12533.5
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.55
    Marker Score: 1158
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.54
    Marker Score: 2542
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 2.54
    Marker Score: 4357
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.54
    Marker Score: 16230
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 2.53
    Marker Score: 1831
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.53
    Marker Score: 2754

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Other Information

**Key characteristics:** * NDUFS5 is a protein of the NADH:ubiquinone oxidoreductase family. * It is a multi-functional protein with activities in both the TCA cycle and respiratory electron transport. * It is involved in the regulation of cellular respiration and energy production. **Pathways and functions:** * NDUFS5 is involved in the TCA cycle, where it catalyzes the transfer of electrons from NADH to coenzyme Q. * It is also involved in the respiratory electron transport pathway, where it transfers electrons to the electron transport chain. * It plays a role in the regulation of cellular respiration by controlling the flow of electrons and protons through the mitochondrial electron transport chain. **Clinical significance:** NDUFS5 gene mutations have been linked to several human diseases, including mitochondrial disorders and metabolic syndromes. Mutations in NDUFS5 have been shown to cause defects in mitochondrial function, leading to energy deficiencies and impaired metabolism. These diseases can be treated with drugs that target NDUFS5, suggesting that the gene plays an important role in maintaining mitochondrial health and preventing disease.

Genular Protein ID: 1983753075

Symbol: NDUS5_HUMAN

Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

UniProtKB Accession Codes:

O43920

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 3 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 9 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9653160

Title: Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning.

PubMed ID: 9653160

DOI: 10.1073/pnas.95.14.8175

PubMed ID: 10070614

Title: The human NADH:ubiquinone oxidoreductase NDUFS5 (15 kDa) subunit: cDNA cloning, chromosomal localization, tissue distribution and the absence of mutations in isolated complex I-deficient patients.

PubMed ID: 10070614

DOI: 10.1023/a:1005434912463

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12611891

Title: The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.

PubMed ID: 12611891

DOI: 10.1074/jbc.c300064200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21310150

Title: NDUFB7 and NDUFA8 are located at the intermembrane surface of complex I.

PubMed ID: 21310150

DOI: 10.1016/j.febslet.2011.01.046

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27626371

Title: Accessory subunits are integral for assembly and function of human mitochondrial complex I.

PubMed ID: 27626371

DOI: 10.1038/nature19754

PubMed ID: 20818383

Title: High-throughput, pooled sequencing identifies mutations in NUBPL and FOXRED1 in human complex I deficiency.

PubMed ID: 20818383

DOI: 10.1038/ng.659

Sequence Information:

  • Length: 106
  • Mass: 12518
  • Checksum: 3D55402837DD99EE
  • Sequence:
    • MPFLDIQKRF GLNIDRWLTI QSGEQPYKMA GRCHAFEKEW IECAHGIGYT RAEKECKIEY 
DDFVECLLRQ KTMRRAGTIR KQRDKLIKEG KYTPPPHHIG KGEPRP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.