Details for: TTN

Gene ID: 7273

Symbol: TTN

Ensembl ID: ENSG00000155657

Description: titin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 164.3895
    Cell Significance Index: -25.5700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 103.2946
    Cell Significance Index: -26.2000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 50.7560
    Cell Significance Index: -20.6200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 27.1999
    Cell Significance Index: 663.6600
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 27.1903
    Cell Significance Index: 438.7200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.7550
    Cell Significance Index: -25.5900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 20.2753
    Cell Significance Index: 521.1700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 18.9385
    Cell Significance Index: 312.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 17.0778
    Cell Significance Index: 1310.5300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 14.7566
    Cell Significance Index: 217.8600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.7643
    Cell Significance Index: -21.3700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 9.3961
    Cell Significance Index: 135.1400
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 7.8128
    Cell Significance Index: 22.3900
  • Cell Name: secondary lymphoid organ macrophage (CL0000867)
    Fold Change: 6.5238
    Cell Significance Index: 47.8900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.5002
    Cell Significance Index: -25.6500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 4.8729
    Cell Significance Index: 37.5600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.6330
    Cell Significance Index: -14.2300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 3.9028
    Cell Significance Index: 56.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.8733
    Cell Significance Index: 356.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.2468
    Cell Significance Index: 39.9300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.2456
    Cell Significance Index: 33.3800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.2227
    Cell Significance Index: 46.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.1450
    Cell Significance Index: 70.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1132
    Cell Significance Index: 223.3000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.9870
    Cell Significance Index: 23.6700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9313
    Cell Significance Index: 184.8100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.7023
    Cell Significance Index: 202.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.6224
    Cell Significance Index: 27.5300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5072
    Cell Significance Index: 9.9000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.4414
    Cell Significance Index: 275.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4019
    Cell Significance Index: 39.7600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4019
    Cell Significance Index: 362.8800
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.2997
    Cell Significance Index: 4.5600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2579
    Cell Significance Index: 30.4200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2487
    Cell Significance Index: 89.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2260
    Cell Significance Index: 12.6800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2070
    Cell Significance Index: 33.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.1651
    Cell Significance Index: 17.1900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1296
    Cell Significance Index: 58.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1213
    Cell Significance Index: 14.1400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1196
    Cell Significance Index: 13.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1094
    Cell Significance Index: 205.9600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0977
    Cell Significance Index: 150.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0966
    Cell Significance Index: 178.2000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0879
    Cell Significance Index: 1.3600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0354
    Cell Significance Index: 48.1700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0324
    Cell Significance Index: 2.1800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0272
    Cell Significance Index: 4.9000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0255
    Cell Significance Index: 17.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0254
    Cell Significance Index: 2.9100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0168
    Cell Significance Index: 10.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0166
    Cell Significance Index: 12.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0085
    Cell Significance Index: -1.4600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0108
    Cell Significance Index: -7.9900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0133
    Cell Significance Index: -5.9000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0134
    Cell Significance Index: -0.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0165
    Cell Significance Index: -2.4000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0213
    Cell Significance Index: -1.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0276
    Cell Significance Index: -0.9700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0279
    Cell Significance Index: -15.7400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0310
    Cell Significance Index: -22.7100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0337
    Cell Significance Index: -18.3900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0415
    Cell Significance Index: -2.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0498
    Cell Significance Index: -10.4800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0612
    Cell Significance Index: -1.5300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0660
    Cell Significance Index: -2.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0830
    Cell Significance Index: -10.2100
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0863
    Cell Significance Index: -0.7600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0875
    Cell Significance Index: -2.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0966
    Cell Significance Index: -12.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1094
    Cell Significance Index: -2.3700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1097
    Cell Significance Index: -15.0700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1265
    Cell Significance Index: -7.7600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1473
    Cell Significance Index: -6.8700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1840
    Cell Significance Index: -2.3600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1931
    Cell Significance Index: -13.6600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1976
    Cell Significance Index: -25.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2185
    Cell Significance Index: -22.3200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2226
    Cell Significance Index: -25.4100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2245
    Cell Significance Index: -2.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2795
    Cell Significance Index: -18.0400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2900
    Cell Significance Index: -4.3700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2927
    Cell Significance Index: -3.6500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2946
    Cell Significance Index: -23.3300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3064
    Cell Significance Index: -19.3100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3073
    Cell Significance Index: -6.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3198
    Cell Significance Index: -15.0300
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.3361
    Cell Significance Index: -4.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3423
    Cell Significance Index: -25.5100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3662
    Cell Significance Index: -3.9900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3673
    Cell Significance Index: -7.6200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3703
    Cell Significance Index: -7.8600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3746
    Cell Significance Index: -19.5100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3835
    Cell Significance Index: -4.8400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3986
    Cell Significance Index: -13.0500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4000
    Cell Significance Index: -20.7800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4070
    Cell Significance Index: -21.3700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.4156
    Cell Significance Index: -3.9400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.4191
    Cell Significance Index: -5.0800
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.4256
    Cell Significance Index: -5.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Titin is a giant protein with a molecular weight of approximately 3,000 kDa. It is composed of three main domains: the N-terminal globular head, the central rod domain, and the C-terminal globular tail. The rod domain is the most critical region, as it provides elasticity to the protein. Titin's unique structure allows it to interact with multiple proteins, including actin, myosin, and calmodulin, which are essential for muscle contraction and relaxation. **Pathways and Functions** Titin's functions can be categorized into several pathways: 1. **Muscle Contraction and Relaxation**: Titin's elasticity allows muscle cells to contract and relax. During contraction, titin stretches, and during relaxation, it recoils, enabling muscle cells to return to their original length. 2. **Sarcomere Organization**: Titin's interaction with actin and myosin filaments is crucial for sarcomere organization and function. 3. **Cardiac Muscle Function**: Titin plays a critical role in cardiac muscle contraction and relaxation, particularly in the ventricular heart. 4. **Skeletal Muscle Function**: Titin also contributes to skeletal muscle contraction and relaxation. **Clinical Significance** Mutations in the TTN gene have been associated with various cardiomyopathies, including: 1. **Dilated Cardiomyopathy**: A condition characterized by an enlarged heart and reduced cardiac function. 2. **Hypertrophic Cardiomyopathy**: A condition characterized by thickened heart muscle and reduced cardiac function. 3. **Arrhythmogenic Right Ventricular Cardiomyopathy**: A condition characterized by abnormal heart rhythm and reduced cardiac function. 4. **Skeletal Muscle Disorders**: Mutations in the TTN gene have also been associated with skeletal muscle disorders, such as myofibrillar myopathies. In addition to its clinical significance, titin is also an important therapeutic target for the treatment of cardiomyopathies. Research has focused on developing therapies that target titin's structure and function to improve cardiac function and reduce the risk of cardiac arrhythmias. In conclusion, titin is a critical protein that plays a central role in muscle contraction and relaxation. Mutations in the TTN gene have significant clinical implications, particularly in cardiomyopathies. Further research is necessary to fully understand the mechanisms of titin's function and to develop effective therapies for the treatment of these diseases.

Genular Protein ID: 3734189958

Symbol: TITIN_HUMAN

Name: Titin

UniProtKB Accession Codes:

Q8WZ42 A6NKB1 E7EQE6 E7ET18 K7ENY1 Q10465 Q10466 Q15598 Q2XUS3 Q32Q60 Q4U1Z6 Q4ZG20 Q6NSG0 Q6PDB1 Q6PJP0 Q7KYM2 Q7KYN4 Q7KYN5 Q7LDM3 Q7Z2X3 Q8TCG8 Q8WZ51 Q8WZ52 Q8WZ53 Q8WZB3 Q92761 Q92762 Q9UD97 Q9UP84 Q9Y6L9

Database IDs:

ABCD 1 AGR 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CDD 9 CORUM 1 CTD 1 CarbonylDB 1 ChEBI 13 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 DisProt 1 EC 3 EMBL 27 EMDB 2 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 43 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 15 KEGG 1 MIM 13 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 12 OrthoDB 1 PANTHER 2 PDB 64 PDBsum 64 PIR 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 11 Pumba 1 Reactome 2 RefSeq 5 Rhea 6 SASBDB 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7569978

Title: Titins, giant proteins in charge of muscle ultrastructure and elasticity.

PubMed ID: 7569978

DOI: 10.1126/science.270.5234.293

PubMed ID: 10850961

Title: Series of exon-skipping events in the elastic spring region of titin as the structural basis for myofibrillar elastic diversity.

PubMed ID: 10850961

DOI: 10.1161/01.res.86.11.1114

PubMed ID: 11717165

Title: The complete gene sequence of titin, expression of an unusual ~700 kDa titin isoform and its interaction with obscurin identify a novel Z-line to I-band linking system.

PubMed ID: 11717165

DOI: 10.1161/hh2301.100981

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8937992

Title: The central Z-disk region of titin is assembled from a novel repeat in variable copy numbers.

PubMed ID: 8937992

DOI: 10.1242/jcs.109.11.2747

PubMed ID: 7819249

Title: Dissecting titin into its structural motifs: identification of an alpha helix near the N-terminus.

PubMed ID: 7819249

DOI: 10.1021/bi00002a021

PubMed ID: 10051295

Title: Familial dilated cardiomyopathy locus maps to chromosome 2q31.

PubMed ID: 10051295

DOI: 10.1161/01.cir.99.8.1022

PubMed ID: 12785098

Title: Species variations in cDNA sequence and exon splicing patterns in the extensible I-band region of cardiac titin: relation to passive tension.

PubMed ID: 12785098

DOI: 10.1023/a:1023410523184

PubMed ID: 8351016

Title: Titin antibodies in myasthenia gravis: identification of a major immunogenic region of titin.

PubMed ID: 8351016

DOI: 10.1212/wnl.43.8.1581

PubMed ID: 1582406

Title: Towards a molecular understanding of titin.

PubMed ID: 1582406

DOI: 10.1002/j.1460-2075.1992.tb05222.x

PubMed ID: 8404852

Title: Phosphorylation of KSF motifs in the C-terminal region of titin in differentiating myoblasts.

PubMed ID: 8404852

DOI: 10.1002/j.1460-2075.1993.tb06061.x

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 9645487

Title: Two immunoglobulin-like domains of the Z-disc portion of titin interact in a conformation-dependent way with telethonin.

PubMed ID: 9645487

DOI: 10.1016/s0014-5793(98)00501-8

PubMed ID: 12482578

Title: Interaction of nebulin SH3 domain with titin PEVK and myopalladin: implications for the signaling and assembly role of titin and nebulin.

PubMed ID: 12482578

DOI: 10.1016/s0014-5793(02)03655-4

PubMed ID: 12432079

Title: Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2.

PubMed ID: 12432079

DOI: 10.1242/jcs.00181

PubMed ID: 12444090

Title: The hydrophilic domain of small ankyrin-1 interacts with the two N-terminal immunoglobulin domains of titin.

PubMed ID: 12444090

DOI: 10.1074/jbc.m209012200

PubMed ID: 14583192

Title: The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules.

PubMed ID: 14583192

DOI: 10.1016/j.jmb.2003.09.012

PubMed ID: 14676215

Title: Association of the chaperone alphaB-crystallin with titin in heart muscle.

PubMed ID: 14676215

DOI: 10.1074/jbc.m307473200

PubMed ID: 15967462

Title: MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination.

PubMed ID: 15967462

DOI: 10.1016/j.jmb.2005.05.021

PubMed ID: 16410549

Title: Nuclear titin interacts with A- and B-type lamins in vitro and in vivo.

PubMed ID: 16410549

DOI: 10.1242/jcs.02728

PubMed ID: 16537787

Title: Mechanical stress-strain sensors embedded in cardiac cytoskeleton: Z disk, titin, and associated structures.

PubMed ID: 16537787

DOI: 10.1152/ajpheart.00816.2005

PubMed ID: 20634290

Title: Interactions with M-band titin and calpain 3 link myospryn (CMYA5) to tibial and limb-girdle muscular dystrophies.

PubMed ID: 20634290

DOI: 10.1074/jbc.m110.108720

PubMed ID: 7613868

Title: Tertiary structure of an immunoglobulin-like domain from the giant muscle protein titin: a new member of the I set.

PubMed ID: 7613868

DOI: 10.1016/s0969-2126(01)00170-8

PubMed ID: 9804419

Title: Structural basis for activation of the titin kinase domain during myofibrillogenesis.

PubMed ID: 9804419

DOI: 10.1038/27603

PubMed ID: 9782056

Title: The three-dimensional structure of a type I module from titin: a prototype of intracellular fibronectin type III domains.

PubMed ID: 9782056

DOI: 10.1016/s0969-2126(98)00129-4

PubMed ID: 11525170

Title: Structural evidence for a possible role of reversible disulphide bridge formation in the elasticity of the muscle protein titin.

PubMed ID: 11525170

DOI: 10.1016/s0969-2126(01)00591-3

PubMed ID: 16407954

Title: Palindromic assembly of the giant muscle protein titin in the sarcomeric Z-disk.

PubMed ID: 16407954

DOI: 10.1038/nature04343

PubMed ID: 10462489

Title: Structural analysis of the titin gene in hypertrophic cardiomyopathy: identification of a novel disease gene.

PubMed ID: 10462489

DOI: 10.1006/bbrc.1999.1221

PubMed ID: 12145747

Title: Tibial muscular dystrophy is a titinopathy caused by mutations in TTN, the gene encoding the giant skeletal-muscle protein titin.

PubMed ID: 12145747

DOI: 10.1086/342380

PubMed ID: 11846417

Title: Titin mutations as the molecular basis for dilated cardiomyopathy.

PubMed ID: 11846417

DOI: 10.1006/bbrc.2002.6448

PubMed ID: 11788824

Title: Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy.

PubMed ID: 11788824

DOI: 10.1038/ng815

PubMed ID: 12891679

Title: Tibial muscular dystrophy in a Belgian family.

PubMed ID: 12891679

DOI: 10.1002/ana.10647

PubMed ID: 16465475

Title: Functional analysis of titin/connectin N2-B mutations found in cardiomyopathy.

PubMed ID: 16465475

DOI: 10.1007/s10974-005-9018-5

PubMed ID: 15802564

Title: The kinase domain of titin controls muscle gene expression and protein turnover.

PubMed ID: 15802564

DOI: 10.1126/science.1110463

PubMed ID: 17444505

Title: C-terminal titin deletions cause a novel early-onset myopathy with fatal cardiomyopathy.

PubMed ID: 17444505

DOI: 10.1002/ana.21089

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

PubMed ID: 25173926

Title: Novel alpha-actinin 2 variant associated with familial hypertrophic cardiomyopathy and juvenile atrial arrhythmias: a massively parallel sequencing study.

PubMed ID: 25173926

DOI: 10.1161/circgenetics.113.000486

Sequence Information:

  • Length: 34350
  • Mass: 3816030
  • Checksum: DEB216410AD560D9
  • Sequence:
    • MTTQAPTFTQ PLQSVVVLEG STATFEAHIS GFPVPEVSWF RDGQVISTST LPGVQISFSD 
GRAKLTIPAV TKANSGRYSL KATNGSGQAT STAELLVKAE TAPPNFVQRL QSMTVRQGSQ 
VRLQVRVTGI PTPVVKFYRD GAEIQSSLDF QISQEGDLYS LLIAEAYPED SGTYSVNATN 
SVGRATSTAE LLVQGEEEVP AKKTKTIVST AQISESRQTR IEKKIEAHFD ARSIATVEMV 
IDGAAGQQLP HKTPPRIPPK PKSRSPTPPS IAAKAQLARQ QSPSPIRHSP SPVRHVRAPT 
PSPVRSVSPA ARISTSPIRS VRSPLLMRKT QASTVATGPE VPPPWKQEGY VASSSEAEMR 
ETTLTTSTQI RTEERWEGRY GVQEQVTISG AAGAAASVSA SASYAAEAVA TGAKEVKQDA 
DKSAAVATVV AAVDMARVRE PVISAVEQTA QRTTTTAVHI QPAQEQVRKE AEKTAVTKVV 
VAADKAKEQE LKSRTKEVIT TKQEQMHVTH EQIRKETEKT FVPKVVISAA KAKEQETRIS 
EEITKKQKQV TQEAIRQETE ITAASMVVVA TAKSTKLETV PGAQEETTTQ QDQMHLSYEK 
IMKETRKTVV PKVIVATPKV KEQDLVSRGR EGITTKREQV QITQEKMRKE AEKTALSTIA 
VATAKAKEQE TILRTRETMA TRQEQIQVTH GKVDVGKKAE AVATVVAAVD QARVREPREP 
GHLEESYAQQ TTLEYGYKER ISAAKVAEPP QRPASEPHVV PKAVKPRVIQ APSETHIKTT 
DQKGMHISSQ IKKTTDLTTE RLVHVDKRPR TASPHFTVSK ISVPKTEHGY EASIAGSAIA 
TLQKELSATS SAQKITKSVK APTVKPSETR VRAEPTPLPQ FPFADTPDTY KSEAGVEVKK 
EVGVSITGTT VREERFEVLH GREAKVTETA RVPAPVEIPV TPPTLVSGLK NVTVIEGESV 
TLECHISGYP SPTVTWYRED YQIESSIDFQ ITFQSGIARL MIREAFAEDS GRFTCSAVNE 
AGTVSTSCYL AVQVSEEFEK ETTAVTEKFT TEEKRFVESR DVVMTDTSLT EEQAGPGEPA 
APYFITKPVV QKLVEGGSVV FGCQVGGNPK PHVYWKKSGV PLTTGYRYKV SYNKQTGECK 
LVISMTFADD AGEYTIVVRN KHGETSASAS LLEEADYELL MKSQQEMLYQ TQVTAFVQEP 
KVGETAPGFV YSEYEKEYEK EQALIRKKMA KDTVVVRTYV EDQEFHISSF EERLIKEIEY 
RIIKTTLEEL LEEDGEEKMA VDISESEAVE SGFDSRIKNY RILEGMGVTF HCKMSGYPLP 
KIAWYKDGKR IKHGERYQMD FLQDGRASLR IPVVLPEDEG IYTAFASNIK GNAICSGKLY 
VEPAAPLGAP TYIPTLEPVS RIRSLSPRSV SRSPIRMSPA RMSPARMSPA RMSPARMSPG 
RRLEETDESQ LERLYKPVFV LKPVSFKCLE GQTARFDLKV VGRPMPETFW FHDGQQIVND 
YTHKVVIKED GTQSLIIVPA TPSDSGEWTV VAQNRAGRSS ISVILTVEAV EHQVKPMFVE 
KLKNVNIKEG SRLEMKVRAT GNPNPDIVWL KNSDIIVPHK YPKIRIEGTK GEAALKIDST 
VSQDSAWYTA TAINKAGRDT TRCKVNVEVE FAEPEPERKL IIPRGTYRAK EIAAPELEPL 
HLRYGQEQWE EGDLYDKEKQ QKPFFKKKLT SLRLKRFGPA HFECRLTPIG DPTMVVEWLH 
DGKPLEAANR LRMINEFGYC SLDYGVAYSR DSGIITCRAT NKYGTDHTSA TLIVKDEKSL 
VEESQLPEGR KGLQRIEELE RMAHEGALTG VTTDQKEKQK PDIVLYPEPV RVLEGETARF 
RCRVTGYPQP KVNWYLNGQL IRKSKRFRVR YDGIHYLDIV DCKSYDTGEV KVTAENPEGV 
IEHKVKLEIQ QREDFRSVLR RAPEPRPEFH VHEPGKLQFE VQKVDRPVDT TETKEVVKLK 
RAERITHEKV PEESEELRSK FKRRTEEGYY EAITAVELKS RKKDESYEEL LRKTKDELLH 
WTKELTEEEK KALAEEGKIT IPTFKPDKIE LSPSMEAPKI FERIQSQTVG QGSDAHFRVR 
VVGKPDPECE WYKNGVKIER SDRIYWYWPE DNVCELVIRD VTAEDSASIM VKAINIAGET 
SSHAFLLVQA KQLITFTQEL QDVVAKEKDT MATFECETSE PFVKVKWYKD GMEVHEGDKY 
RMHSDRKVHF LSILTIDTSD AEDYSCVLVE DENVKTTAKL IVEGAVVEFV KELQDIEVPE 
SYSGELECIV SPENIEGKWY HNDVELKSNG KYTITSRRGR QNLTVKDVTK EDQGEYSFVI 
DGKKTTCKLK MKPRPIAILQ GLSDQKVCEG DIVQLEVKVS LESVEGVWMK DGQEVQPSDR 
VHIVIDKQSH MLLIEDMTKE DAGNYSFTIP ALGLSTSGRV SVYSVDVITP LKDVNVIEGT 
KAVLECKVSV PDVTSVKWYL NDEQIKPDDR VQAIVKGTKQ RLVINRTHAS DEGPYKLIVG 
RVETNCNLSV EKIKIIRGLR DLTCTETQNV VFEVELSHSG IDVLWNFKDK EIKPSSKYKI 
EAHGKIYKLT VLNMMKDDEG KYTFYAGENM TSGKLTVAGG AISKPLTDQT VAESQEAVFE 
CEVANPDSKG EWLRDGKHLP LTNNIRSESD GHKRRLIIAA TKLDDIGEYT YKVATSKTSA 
KLKVEAVKIK KTLKNLTVTE TQDAVFTVEL THPNVKGVQW IKNGVVLESN EKYAISVKGT 
IYSLRIKNCA IVDESVYGFR LGRLGASARL HVETVKIIKK PKDVTALENA TVAFEVSVSH 
DTVPVKWFHK SVEIKPSDKH RLVSERKVHK LMLQNISPSD AGEYTAVVGQ LECKAKLFVE 
TLHITKTMKN IEVPETKTAS FECEVSHFNV PSMWLKNGVE IEMSEKFKIV VQGKLHQLII 
MNTSTEDSAE YTFVCGNDQV SATLTVTPIM ITSMLKDINA EEKDTITFEV TVNYEGISYK 
WLKNGVEIKS TDKCQMRTKK LTHSLNIRNV HFGDAADYTF VAGKATSTAT LYVEARHIEF 
RKHIKDIKVL EKKRAMFECE VSEPDITVQW MKDDQELQIT DRIKIQKEKY VHRLLIPSTR 
MSDAGKYTVV AGGNVSTAKL FVEGRDVRIR SIKKEVQVIE KQRAVVEFEV NEDDVDAHWY 
KDGIEINFQV QERHKYVVER RIHRMFISET RQSDAGEYTF VAGRNRSSVT LYVNAPEPPQ 
VLQELQPVTV QSGKPARFCA VISGRPQPKI SWYKEEQLLS TGFKCKFLHD GQEYTLLLIE 
AFPEDAAVYT CEAKNDYGVA TTSASLSVEV PEVVSPDQEM PVYPPAIITP LQDTVTSEGQ 
PARFQCRVSG TDLKVSWYSK DKKIKPSRFF RMTQFEDTYQ LEIAEAYPED EGTYTFVASN 
AVGQVSSTAN LSLEAPESIL HERIEQEIEM EMKEFSSSFL SAEEEGLHSA ELQLSKINET 
LELLSESPVY PTKFDSEKEG TGPIFIKEVS NADISMGDVA TLSVTVIGIP KPKIQWFFNG 
VLLTPSADYK FVFDGDDHSL IILFTKLEDE GEYTCMASND YGKTICSAYL KINSKGEGHK 
DTETESAVAK SLEKLGGPCP PHFLKELKPI RCAQGLPAIF EYTVVGEPAP TVTWFKENKQ 
LCTSVYYTII HNPNGSGTFI VNDPQREDSG LYICKAENML GESTCAAELL VLLEDTDMTD 
TPCKAKSTPE APEDFPQTPL KGPAVEALDS EQEIATFVKD TILKAALITE ENQQLSYEHI 
AKANELSSQL PLGAQELQSI LEQDKLTPES TREFLCINGS IHFQPLKEPS PNLQLQIVQS 
QKTFSKEGIL MPEEPETQAV LSDTEKIFPS AMSIEQINSL TVEPLKTLLA EPEGNYPQSS 
IEPPMHSYLT SVAEEVLSPK EKTVSDTNRE QRVTLQKQEA QSALILSQSL AEGHVESLQS 
PDVMISQVNY EPLVPSEHSC TEGGKILIES ANPLENAGQD SAVRIEEGKS LRFPLALEEK 
QVLLKEEHSD NVVMPPDQII ESKREPVAIK KVQEVQGRDL LSKESLLSGI PEEQRLNLKI 
QICRALQAAV ASEQPGLFSE WLRNIEKVEV EAVNITQEPR HIMCMYLVTS AKSVTEEVTI 
IIEDVDPQMA NLKMELRDAL CAIIYEEIDI LTAEGPRIQQ GAKTSLQEEM DSFSGSQKVE 
PITEPEVESK YLISTEEVSY FNVQSRVKYL DATPVTKGVA SAVVSDEKQD ESLKPSEEKE 
ESSSESGTEE VATVKIQEAE GGLIKEDGPM IHTPLVDTVS EEGDIVHLTT SITNAKEVNW 
YFENKLVPSD EKFKCLQDQN TYTLVIDKVN TEDHQGEYVC EALNDSGKTA TSAKLTVVKR 
AAPVIKRKIE PLEVALGHLA KFTCEIQSAP NVRFQWFKAG REIYESDKCS IRSSKYISSL 
EILRTQVVDC GEYTCKASNE YGSVSCTATL TVTEAYPPTF LSRPKSLTTF VGKAAKFICT 
VTGTPVIETI WQKDGAALSP SPNWRISDAE NKHILELSNL TIQDRGVYSC KASNKFGADI 
CQAELIIIDK PHFIKELEPV QSAINKKVHL ECQVDEDRKV TVTWSKDGQK LPPGKDYKIC 
FEDKIATLEI PLAKLKDSGT YVCTASNEAG SSSCSATVTV REPPSFVKKV DPSYLMLPGE 
SARLHCKLKG SPVIQVTWFK NNKELSESNT VRMYFVNSEA ILDITDVKVE DSGSYSCEAV 
NDVGSDSCST EIVIKEPPSF IKTLEPADIV RGTNALLQCE VSGTGPFEIS WFKDKKQIRS 
SKKYRLFSQK SLVCLEIFSF NSADVGEYEC VVANEVGKCG CMATHLLKEP PTFVKKVDDL 
IALGGQTVTL QAAVRGSEPI SVTWMKGQEV IREDGKIKMS FSNGVAVLII PDVQISFGGK 
YTCLAENEAG SQTSVGELIV KEPAKIIERA ELIQVTAGDP ATLEYTVAGT PELKPKWYKD 
GRPLVASKKY RISFKNNVAQ LKFYSAELHD SGQYTFEISN EVGSSSCETT FTVLDRDIAP 
FFTKPLRNVD SVVNGTCRLD CKIAGSLPMR VSWFKDGKEI AASDRYRIAF VEGTASLEII 
RVDMNDAGNF TCRATNSVGS KDSSGALIVQ EPPSFVTKPG SKDVLPGSAV CLKSTFQGST 
PLTIRWFKGN KELVSGGSCY ITKEALESSL ELYLVKTSDS GTYTCKVSNV AGGVECSANL 
FVKEPATFVE KLEPSQLLKK GDATQLACKV TGTPPIKITW FANDREIKES SKHRMSFVES 
TAVLRLTDVG IEDSGEYMCE AQNEAGSDHC SSIVIVKESP YFTKEFKPIE VLKEYDVMLL 
AEVAGTPPFE ITWFKDNTIL RSGRKYKTFI QDHLVSLQIL KFVAADAGEY QCRVTNEVGS 
SICSARVTLR EPPSFIKKIE STSSLRGGTA AFQATLKGSL PITVTWLKDS DEITEDDNIR 
MTFENNVASL YLSGIEVKHD GKYVCQAKND AGIQRCSALL SVKEPATITE EAVSIDVTQG 
DPATLQVKFS GTKEITAKWF KDGQELTLGS KYKISVTDTV SILKIISTEK KDSGEYTFEV 
QNDVGRSSCK ARINVLDLII PPSFTKKLKK MDSIKGSFID LECIVAGSHP ISIQWFKDDQ 
EISASEKYKF SFHDNTAFLE ISQLEGTDSG TYTCSATNKA GHNQCSGHLT VKEPPYFVEK 
PQSQDVNPNT RVQLKALVGG TAPMTIKWFK DNKELHSGAA RSVWKDDTST SLELFAAKAT 
DSGTYICQLS NDVGTATSKA TLFVKEPPQF IKKPSPVLVL RNGQSTTFEC QITGTPKIRV 
SWYLDGNEIT AIQKHGISFI DGLATFQISG ARVENSGTYV CEARNDAGTA SCSIELKVKE 
PPTFIRELKP VEVVKYSDVE LECEVTGTPP FEVTWLKNNR EIRSSKKYTL TDRVSVFNLH 
ITKCDPSDTG EYQCIVSNEG GSCSCSTRVA LKEPPSFIKK IENTTTVLKS SATFQSTVAG 
SPPISITWLK DDQILDEDDN VYISFVDSVA TLQIRSVDNG HSGRYTCQAK NESGVERCYA 
FLLVQEPAQI VEKAKSVDVT EKDPMTLECV VAGTPELKVK WLKDGKQIVP SRYFSMSFEN 
NVASFRIQSV MKQDSGQYTF KVENDFGSSS CDAYLRVLDQ NIPPSFTKKL TKMDKVLGSS 
IHMECKVSGS LPISAQWFKD GKEISTSAKY RLVCHERSVS LEVNNLELED TANYTCKVSN 
VAGDDACSGI LTVKEPPSFL VKPGRQQAIP DSTVEFKAIL KGTPPFKIKW FKDDVELVSG 
PKCFIGLEGS TSFLNLYSVD ASKTGQYTCH VTNDVGSDSC TTMLLVTEPP KFVKKLEASK 
IVKAGDSSRL ECKIAGSPEI RVVWFRNEHE LPASDKYRMT FIDSVAVIQM NNLSTEDSGD 
FICEAQNPAG STSCSTKVIV KEPPVFSSFP PIVETLKNAE VSLECELSGT PPFEVVWYKD 
KRQLRSSKKY KIASKNFHTS IHILNVDTSD IGEYHCKAQN EVGSDTCVCT VKLKEPPRFV 
SKLNSLTVVA GEPAELQASI EGAQPIFVQW LKEKEEVIRE SENIRITFVE NVATLQFAKA 
EPANAGKYIC QIKNDGGMRE NMATLMVLEP AVIVEKAGPM TVTVGETCTL ECKVAGTPEL 
SVEWYKDGKL LTSSQKHKFS FYNKISSLRI LSVERQDAGT YTFQVQNNVG KSSCTAVVDV 
SDRAVPPSFT RRLKNTGGVL GASCILECKV AGSSPISVAW FHEKTKIVSG AKYQTTFSDN 
VCTLQLNSLD SSDMGNYTCV AANVAGSDEC RAVLTVQEPP SFVKEPEPLE VLPGKNVTFT 
SVIRGTPPFK VNWFRGAREL VKGDRCNIYF EDTVAELELF NIDISQSGEY TCVVSNNAGQ 
ASCTTRLFVK EPAAFLKRLS DHSVEPGKSI ILESTYTGTL PISVTWKKDG FNITTSEKCN 
IVTTEKTCIL EILNSTKRDA GQYSCEIENE AGRDVCGALV STLEPPYFVT ELEPLEAAVG 
DSVSLQCQVA GTPEITVSWY KGDTKLRPTP EYRTYFTNNV ATLVFNKVNI NDSGEYTCKA 
ENSIGTASSK TVFRIQERQL PPSFARQLKD IEQTVGLPVT LTCRLNGSAP IQVCWYRDGV 
LLRDDENLQT SFVDNVATLK ILQTDLSHSG QYSCSASNPL GTASSSARLT AREPKKSPFF 
DIKPVSIDVI AGESADFECH VTGAQPMRIT WSKDNKEIRP GGNYTITCVG NTPHLRILKV 
GKGDSGQYTC QATNDVGKDM CSAQLSVKEP PKFVKKLEAS KVAKQGESIQ LECKISGSPE 
IKVSWFRNDS ELHESWKYNM SFINSVALLT INEASAEDSG DYICEAHNGV GDASCSTALT 
VKAPPVFTQK PSPVGALKGS DVILQCEISG TPPFEVVWVK DRKQVRNSKK FKITSKHFDT 
SLHILNLEAS DVGEYHCKAT NEVGSDTCSC SVKFKEPPRF VKKLSDTSTL IGDAVELRAI 
VEGFQPISVV WLKDRGEVIR ESENTRISFI DNIATLQLGS PEASNSGKYI CQIKNDAGMR 
ECSAVLTVLE PARIIEKPEP MTVTTGNPFA LECVVTGTPE LSAKWFKDGR ELSADSKHHI 
TFINKVASLK IPCAEMSDKG LYSFEVKNSV GKSNCTVSVH VSDRIVPPSF IRKLKDVNAI 
LGASVVLECR VSGSAPISVG WFQDGNEIVS GPKCQSSFSE NVCTLNLSLL EPSDTGIYTC 
VAANVAGSDE CSAVLTVQEP PSFEQTPDSV EVLPGMSLTF TSVIRGTPPF KVKWFKGSRE 
LVPGESCNIS LEDFVTELEL FEVQPLESGD YSCLVTNDAG SASCTTHLFV KEPATFVKRL 
ADFSVETGSP IVLEATYTGT PPISVSWIKD EYLISQSERC SITMTEKSTI LEILESTIED 
YAQYSCLIEN EAGQDICEAL VSVLEPPYFI EPLEHVEAVI GEPATLQCKV DGTPEIRISW 
YKEHTKLRSA PAYKMQFKNN VASLVINKVD HSDVGEYSCK ADNSVGAVAS SAVLVIKARK 
LPPFFARKLK DVHETLGFPV AFECRINGSE PLQVSWYKDG VLLKDDANLQ TSFVHNVATL 
QILQTDQSHI GQYNCSASNP LGTASSSAKL ILSEHEVPPF FDLKPVSVDL ALGESGTFKC 
HVTGTAPIKI TWAKDNREIR PGGNYKMTLV ENTATLTVLK VGKGDAGQYT CYASNIAGKD 
SCSAQLGVQE PPRFIKKLEP SRIVKQDEFT RYECKIGGSP EIKVLWYKDE TEIQESSKFR 
MSFVDSVAVL EMHNLSVEDS GDYTCEAHNA AGSASSSTSL KVKEPPIFRK KPHPIETLKG 
ADVHLECELQ GTPPFHVSWY KDKRELRSGK KYKIMSENFL TSIHILNVDA ADIGEYQCKA 
TNDVGSDTCV GSIALKAPPR FVKKLSDIST VVGKEVQLQT TIEGAEPISV VWFKDKGEIV 
RESDNIWISY SENIATLQFS RVEPANAGKY TCQIKNDAGM QECFATLSVL EPATIVEKPE 
SIKVTTGDTC TLECTVAGTP ELSTKWFKDG KELTSDNKYK ISFFNKVSGL KIINVAPSDS 
GVYSFEVQNP VGKDSCTASL QVSDRTVPPS FTRKLKETNG LSGSSVVMEC KVYGSPPISV 
SWFHEGNEIS SGRKYQTTLT DNTCALTVNM LEESDSGDYT CIATNMAGSD ECSAPLTVRE 
PPSFVQKPDP MDVLTGTNVT FTSIVKGTPP FSVSWFKGSS ELVPGDRCNV SLEDSVAELE 
LFDVDTSQSG EYTCIVSNEA GKASCTTHLY IKAPAKFVKR LNDYSIEKGK PLILEGTFTG 
TPPISVTWKK NGINVTPSQR CNITTTEKSA ILEIPSSTVE DAGQYNCYIE NASGKDSCSA 
QILILEPPYF VKQLEPVKVS VGDSASLQCQ LAGTPEIGVS WYKGDTKLRP TTTYKMHFRN 
NVATLVFNQV DINDSGEYIC KAENSVGEVS ASTFLTVQEQ KLPPSFSRQL RDVQETVGLP 
VVFDCAISGS EPISVSWYKD GKPLKDSPNV QTSFLDNTAT LNIFKTDRSL AGQYSCTATN 
PIGSASSSAR LILTEGKNPP FFDIRLAPVD AVVGESADFE CHVTGTQPIK VSWAKDSREI 
RSGGKYQISY LENSAHLTVL KVDKGDSGQY TCYAVNEVGK DSCTAQLNIK ERLIPPSFTK 
RLSETVEETE GNSFKLEGRV AGSQPITVAW YKNNIEIQPT SNCEITFKNN TLVLQVRKAG 
MNDAGLYTCK VSNDAGSALC TSSIVIKEPK KPPVFDQHLT PVTVSEGEYV QLSCHVQGSE 
PIRIQWLKAG REIKPSDRCS FSFASGTAVL ELRDVAKADS GDYVCKASNV AGSDTTKSKV 
TIKDKPAVAP ATKKAAVDGR LFFVSEPQSI RVVEKTTATF IAKVGGDPIP NVKWTKGKWR 
QLNQGGRVFI HQKGDEAKLE IRDTTKTDSG LYRCVAFNEH GEIESNVNLQ VDERKKQEKI 
EGDLRAMLKK TPILKKGAGE EEEIDIMELL KNVDPKEYEK YARMYGITDF RGLLQAFELL 
KQSQEEETHR LEIEEIERSE RDEKEFEELV SFIQQRLSQT EPVTLIKDIE NQTVLKDNDA 
VFEIDIKINY PEIKLSWYKG TEKLEPSDKF EISIDGDRHT LRVKNCQLKD QGNYRLVCGP 
HIASAKLTVI EPAWERHLQD VTLKEGQTCT MTCQFSVPNV KSEWFRNGRI LKPQGRHKTE 
VEHKVHKLTI ADVRAEDQGQ YTCKYEDLET SAELRIEAEP IQFTKRIQNI VVSEHQSATF 
ECEVSFDDAI VTWYKGPTEL TESQKYNFRN DGRCHYMTIH NVTPDDEGVY SVIARLEPRG 
EARSTAELYL TTKEIKLELK PPDIPDSRVP IPTMPIRAVP PEEIPPVVAP PIPLLLPTPE 
EKKPPPKRIE VTKKAVKKDA KKVVAKPKEM TPREEIVKKP PPPTTLIPAK APEIIDVSSK 
AEEVKIMTIT RKKEVQKEKE AVYEKKQAVH KEKRVFIESF EEPYDELEVE PYTEPFEQPY 
YEEPDEDYEE IKVEAKKEVH EEWEEDFEEG QEYYEREEGY DEGEEEWEEA YQEREVIQVQ 
KEVYEESHER KVPAKVPEKK APPPPKVIKK PVIEKIEKTS RRMEEEKVQV TKVPEVSKKI 
VPQKPSRTPV QEEVIEVKVP AVHTKKMVIS EEKMFFASHT EEEVSVTVPE VQKEIVTEEK 
IHVAISKRVE PPPKVPELPE KPAPEEVAPV PIPKKVEPPA PKVPEVPKKP VPEEKKPVPV 
PKKEPAAPPK VPEVPKKPVP EEKIPVPVAK KKEAPPAKVP EVQKGVVTEE KITIVTQREE 
SPPPAVPEIP KKKVPEERKP VPRKEEEVPP PPKVPALPKK PVPEEKVAVP VPVAKKAPPP 
RAEVSKKTVV EEKRFVAEEK LSFAVPQRVE VTRHEVSAEE EWSYSEEEEG VSISVYREEE 
REEEEEAEVT EYEVMEEPEE YVVEEKLHII SKRVEAEPAE VTERQEKKIV LKPKIPAKIE 
EPPPAKVPEA PKKIVPEKKV PAPVPKKEKV PPPKVPEEPK KPVPEKKVPP KVIKMEEPLP 
AKVTERHMQI TQEEKVLVAV TKKEAPPKAR VPEEPKRAVP EEKVLKLKPK REEEPPAKVT 
EFRKRVVKEE KVSIEAPKRE PQPIKEVTIM EEKERAYTLE EEAVSVQREE EYEEYEEYDY 
KEFEEYEPTE EYDQYEEYEE REYERYEEHE EYITEPEKPI PVKPVPEEPV PTKPKAPPAK 
VLKKAVPEEK VPVPIPKKLK PPPPKVPEEP KKVFEEKIRI SITKREKEQV TEPAAKVPMK 
PKRVVAEEKV PVPRKEVAPP VRVPEVPKEL EPEEVAFEEE VVTHVEEYLV EEEEEYIHEE 
EEFITEEEVV PVIPVKVPEV PRKPVPEEKK PVPVPKKKEA PPAKVPEVPK KPEEKVPVLI 
PKKEKPPPAK VPEVPKKPVP EEKVPVPVPK KVEAPPAKVP EVPKKPVPEK KVPVPAPKKV 
EAPPAKVPEV PKKLIPEEKK PTPVPKKVEA PPPKVPKKRE PVPVPVALPQ EEEVLFEEEI 
VPEEEVLPEE EEVLPEEEEV LPEEEEVLPE EEEIPPEEEE VPPEEEYVPE EEEFVPEEEV 
LPEVKPKVPV PAPVPEIKKK VTEKKVVIPK KEEAPPAKVP EVPKKVEEKR IILPKEEEVL 
PVEVTEEPEE EPISEEEIPE EPPSIEEVEE VAPPRVPEVI KKAVPEAPTP VPKKVEAPPA 
KVSKKIPEEK VPVPVQKKEA PPAKVPEVPK KVPEKKVLVP KKEAVPPAKG RTVLEEKVSV 
AFRQEVVVKE RLELEVVEAE VEEIPEEEEF HEVEEYFEEG EFHEVEEFIK LEQHRVEEEH 
RVEKVHRVIE VFEAEEVEVF EKPKAPPKGP EISEKIIPPK KPPTKVVPRK EPPAKVPEVP 
KKIVVEEKVR VPEEPRVPPT KVPEVLPPKE VVPEKKVPVP PAKKPEAPPP KVPEAPKEVV 
PEKKVPVPPP KKPEVPPTKV PEVPKAAVPE KKVPEAIPPK PESPPPEVPE APKEVVPEKK 
VPAAPPKKPE VTPVKVPEAP KEVVPEKKVP VPPPKKPEVP PTKVPEVPKV AVPEKKVPEA 
IPPKPESPPP EVFEEPEEVA LEEPPAEVVE EPEPAAPPQV TVPPKKPVPE KKAPAVVAKK 
PELPPVKVPE VPKEVVPEKK VPLVVPKKPE APPAKVPEVP KEVVPEKKVA VPKKPEVPPA 
KVPEVPKKPV LEEKPAVPVP ERAESPPPEV YEEPEEIAPE EEIAPEEEKP VPVAEEEEPE 
VPPPAVPEEP KKIIPEKKVP VIKKPEAPPP KEPEPEKVIE KPKLKPRPPP PPPAPPKEDV 
KEKIFQLKAI PKKKVPEKPQ VPEKVELTPL KVPGGEKKVR KLLPERKPEP KEEVVLKSVL 
RKRPEEEEPK VEPKKLEKVK KPAVPEPPPP KPVEEVEVPT VTKRERKIPE PTKVPEIKPA 
IPLPAPEPKP KPEAEVKTIK PPPVEPEPTP IAAPVTVPVV GKKAEAKAPK EEAAKPKGPI 
KGVPKKTPSP IEAERRKLRP GSGGEKPPDE APFTYQLKAV PLKFVKEIKD IILTESEFVG 
SSAIFECLVS PSTAITTWMK DGSNIRESPK HRFIADGKDR KLHIIDVQLS DAGEYTCVLR 
LGNKEKTSTA KLVVEELPVR FVKTLEEEVT VVKGQPLYLS CELNKERDVV WRKDGKIVVE 
KPGRIVPGVI GLMRALTIND ADDTDAGTYT VTVENANNLE CSSCVKVVEV IRDWLVKPIR 
DQHVKPKGTA IFACDIAKDT PNIKWFKGYD EIPAEPNDKT EILRDGNHLY LKIKNAMPED 
IAEYAVEIEG KRYPAKLTLG EREVELLKPI EDVTIYEKES ASFDAEISEA DIPGQWKLKG 
ELLRPSPTCE IKAEGGKRFL TLHKVKLDQA GEVLYQALNA ITTAILTVKE IELDFAVPLK 
DVTVPERRQA RFECVLTREA NVIWSKGPDI IKSSDKFDII ADGKKHILVI NDSQFDDEGV 
YTAEVEGKKT SARLFVTGIR LKFMSPLEDQ TVKEGETATF VCELSHEKMH VVWFKNDAKL 
HTSRTVLISS EGKTHKLEMK EVTLDDISQI KAQVKELSST AQLKVLEADP YFTVKLHDKT 
AVEKDEITLK CEVSKDVPVK WFKDGEEIVP SPKYSIKADG LRRILKIKKA DLKDKGEYVC 
DCGTDKTKAN VTVEARLIKV EKPLYGVEVF VGETAHFEIE LSEPDVHGQW KLKGQPLTAS 
PDCEIIEDGK KHILILHNCQ LGMTGEVSFQ AANAKSAANL KVKELPLIFI TPLSDVKVFE 
KDEAKFECEV SREPKTFRWL KGTQEITGDD RFELIKDGTK HSMVIKSAAF EDEAKYMFEA 
EDKHTSGKLI IEGIRLKFLT PLKDVTAKEK ESAVFTVELS HDNIRVKWFK NDQRLHTTRS 
VSMQDEGKTH SITFKDLSID DTSQIRVEAM GMSSEAKLTV LEGDPYFTGK LQDYTGVEKD 
EVILQCEISK ADAPVKWFKD GKEIKPSKNA VIKADGKKRM LILKKALKSD IGQYTCDCGT 
DKTSGKLDIE DREIKLVRPL HSVEVMETET ARFETEISED DIHANWKLKG EALLQTPDCE 
IKEEGKIHSL VLHNCRLDQT GGVDFQAANV KSSAHLRVKP RVIGLLRPLK DVTVTAGETA 
TFDCELSYED IPVEWYLKGK KLEPSDKVVP RSEGKVHTLT LRDVKLEDAG EVQLTAKDFK 
THANLFVKEP PVEFTKPLED QTVEEGATAV LECEVSRENA KVKWFKNGTE ILKSKKYEIV 
ADGRVRKLVI HDCTPEDIKT YTCDAKDFKT SCNLNVVPPH VEFLRPLTDL QVREKEMARF 
ECELSRENAK VKWFKDGAEI KKGKKYDIIS KGAVRILVIN KCLLDDEAEY SCEVRTARTS 
GMLTVLEEEA VFTKNLANIE VSETDTIKLV CEVSKPGAEV IWYKGDEEII ETGRYEILTE 
GRKRILVIQN AHLEDAGNYN CRLPSSRTDG KVKVHELAAE FISKPQNLEI LEGEKAEFVC 
SISKESFPVQ WKRDDKTLES GDKYDVIADG KKRVLVVKDA TLQDMGTYVV MVGAARAAAH 
LTVIEKLRIV VPLKDTRVKE QQEVVFNCEV NTEGAKAKWF RNEEAIFDSS KYIILQKDLV 
YTLRIRDAHL DDQANYNVSL TNHRGENVKS AANLIVEEED LRIVEPLKDI ETMEKKSVTF 
WCKVNRLNVT LKWTKNGEEV PFDNRVSYRV DKYKHMLTIK DCGFPDEGEY IVTAGQDKSV 
AELLIIEAPT EFVEHLEDQT VTEFDDAVFS CQLSREKANV KWYRNGREIK EGKKYKFEKD 
GSIHRLIIKD CRLDDECEYA CGVEDRKSRA RLFVEEIPVE IIRPPQDILE APGADVVFLA 
ELNKDKVEVQ WLRNNMVVVQ GDKHQMMSEG KIHRLQICDI KPRDQGEYRF IAKDKEARAK 
LELAAAPKIK TADQDLVVDV GKPLTMVVPY DAYPKAEAEW FKENEPLSTK TIDTTAEQTS 
FRILEAKKGD KGRYKIVLQN KHGKAEGFIN LKVIDVPGPV RNLEVTETFD GEVSLAWEEP 
LTDGGSKIIG YVVERRDIKR KTWVLATDRA ESCEFTVTGL QKGGVEYLFR VSARNRVGTG 
EPVETDNPVE ARSKYDVPGP PLNVTITDVN RFGVSLTWEP PEYDGGAEIT NYVIELRDKT 
SIRWDTAMTV RAEDLSATVT DVVEGQEYSF RVRAQNRIGV GKPSAATPFV KVADPIERPS 
PPVNLTSSDQ TQSSVQLKWE PPLKDGGSPI LGYIIERCEE GKDNWIRCNM KLVPELTYKV 
TGLEKGNKYL YRVSAENKAG VSDPSEILGP LTADDAFVEP TMDLSAFKDG LEVIVPNPIT 
ILVPSTGYPR PTATWCFGDK VLETGDRVKM KTLSAYAELV ISPSERSDKG IYTLKLENRV 
KTISGEIDVN VIARPSAPKE LKFGDITKDS VHLTWEPPDD DGGSPLTGYV VEKREVSRKT 
WTKVMDFVTD LEFTVPDLVQ GKEYLFKVCA RNKCGPGEPA YVDEPVNMST PATVPDPPEN 
VKWRDRTANS IFLTWDPPKN DGGSRIKGYI VERCPRGSDK WVACGEPVAE TKMEVTGLEE 
GKWYAYRVKA LNRQGASKPS RPTEEIQAVD TQEAPEIFLD VKLLAGLTVK AGTKIELPAT 
VTGKPEPKIT WTKADMILKQ DKRITIENVP KKSTVTIVDS KRSDTGTYII EAVNVCGRAT 
AVVEVNVLDK PGPPAAFDIT DVTNESCLLT WNPPRDDGGS KITNYVVERR ATDSEVWHKL 
SSTVKDTNFK ATKLIPNKEY IFRVAAENMY GVGEPVQASP ITAKYQFDPP GPPTRLEPSD 
ITKDAVTLTW CEPDDDGGSP ITGYWVERLD PDTDKWVRCN KMPVKDTTYR VKGLTNKKKY 
RFRVLAENLA GPGKPSKSTE PILIKDPIDP PWPPGKPTVK DVGKTSVRLN WTKPEHDGGA 
KIESYVIEML KTGTDEWVRV AEGVPTTQHL LPGLMEGQEY SFRVRAVNKA GESEPSEPSD 
PVLCREKLYP PSPPRWLEVI NITKNTADLK WTVPEKDGGS PITNYIVEKR DVRRKGWQTV 
DTTVKDTKCT VTPLTEGSLY VFRVAAENAI GQSDYTEIED SVLAKDTFTT PGPPYALAVV 
DVTKRHVDLK WEPPKNDGGR PIQRYVIEKK ERLGTRWVKA GKTAGPDCNF RVTDVIEGTE 
VQFQVRAENE AGVGHPSEPT EILSIEDPTS PPSPPLDLHV TDAGRKHIAI AWKPPEKNGG 
SPIIGYHVEM CPVGTEKWMR VNSRPIKDLK FKVEEGVVPD KEYVLRVRAV NAIGVSEPSE 
ISENVVAKDP DCKPTIDLET HDIIVIEGEK LSIPVPFRAV PVPTVSWHKD GKEVKASDRL 
TMKNDHISAH LEVPKSVRAD AGIYTITLEN KLGSATASIN VKVIGLPGPC KDIKASDITK 
SSCKLTWEPP EFDGGTPILH YVLERREAGR RTYIPVMSGE NKLSWTVKDL IPNGEYFFRV 
KAVNKVGGGE YIELKNPVIA QDPKQPPDPP VDVEVHNPTA EAMTITWKPP LYDGGSKIMG 
YIIEKIAKGE ERWKRCNEHL VPILTYTAKG LEEGKEYQFR VRAENAAGIS EPSRATPPTK 
AVDPIDAPKV ILRTSLEVKR GDEIALDASI SGSPYPTITW IKDENVIVPE EIKKRAAPLV 
RRRKGEVQEE EPFVLPLTQR LSIDNSKKGE SQLRVRDSLR PDHGLYMIKV ENDHGIAKAP 
CTVSVLDTPG PPINFVFEDI RKTSVLCKWE PPLDDGGSEI INYTLEKKDK TKPDSEWIVV 
TSTLRHCKYS VTKLIEGKEY LFRVRAENRF GPGPPCVSKP LVAKDPFGPP DAPDKPIVED 
VTSNSMLVKW NEPKDNGSPI LGYWLEKREV NSTHWSRVNK SLLNALKANV DGLLEGLTYV 
FRVCAENAAG PGKFSPPSDP KTAHDPISPP GPPIPRVTDT SSTTIELEWE PPAFNGGGEI 
VGYFVDKQLV GTNEWSRCTE KMIKVRQYTV KEIREGADYK LRVSAVNAAG EGPPGETQPV 
TVAEPQEPPA VELDVSVKGG IQIMAGKTLR IPAVVTGRPV PTKVWTKEEG ELDKDRVVID 
NVGTKSELII KDALRKDHGR YVITATNSCG SKFAAARVEV FDVPGPVLDL KPVVTNRKMC 
LLNWSDPEDD GGSEITGFII ERKDAKMHTW RQPIETERSK CDITGLLEGQ EYKFRVIAKN 
KFGCGPPVEI GPILAVDPLG PPTSPERLTY TERTKSTITL DWKEPRSNGG SPIQGYIIEK 
RRHDKPDFER VNKRLCPTTS FLVENLDEHQ MYEFRVKAVN EIGESEPSLP LNVVIQDDEV 
PPTIKLRLSV RGDTIKVKAG EPVHIPADVT GLPMPKIEWS KNETVIEKPT DALQITKEEV 
SRSEAKTELS IPKAVREDKG TYTVTASNRL GSVFRNVHVE VYDRPSPPRN LAVTDIKAES 
CYLTWDAPLD NGGSEITHYV IDKRDASRKK AEWEEVTNTA VEKRYGIWKL IPNGQYEFRV 
RAVNKYGISD ECKSDKVVIQ DPYRLPGPPG KPKVLARTKG SMLVSWTPPL DNGGSPITGY 
WLEKREEGSP YWSRVSRAPI TKVGLKGVEF NVPRLLEGVK YQFRAMAINA AGIGPPSEPS 
DPEVAGDPIF PPGPPSCPEV KDKTKSSISL GWKPPAKDGG SPIKGYIVEM QEEGTTDWKR 
VNEPDKLITT CECVVPNLKE LRKYRFRVKA VNEAGESEPS DTTGEIPATD IQEEPEVFID 
IGAQDCLVCK AGSQIRIPAV IKGRPTPKSS WEFDGKAKKA MKDGVHDIPE DAQLETAENS 
SVIIIPECKR SHTGKYSITA KNKAGQKTAN CRVKVMDVPG PPKDLKVSDI TRGSCRLSWK 
MPDDDGGDRI KGYVIEKRTI DGKAWTKVNP DCGSTTFVVP DLLSEQQYFF RVRAENRFGI 
GPPVETIQRT TARDPIYPPD PPIKLKIGLI TKNTVHLSWK PPKNDGGSPV THYIVECLAW 
DPTGTKKEAW RQCNKRDVEE LQFTVEDLVE GGEYEFRVKA VNAAGVSKPS ATVGPVTVKD 
QTCPPSIDLK EFMEVEEGTN VNIVAKIKGV PFPTLTWFKA PPKKPDNKEP VLYDTHVNKL 
VVDDTCTLVI PQSRRSDTGL YTITAVNNLG TASKEMRLNV LGRPGPPVGP IKFESVSADQ 
MTLSWFPPKD DGGSKITNYV IEKREANRKT WVHVSSEPKE CTYTIPKLLE GHEYVFRIMA 
QNKYGIGEPL DSEPETARNL FSVPGAPDKP TVSSVTRNSM TVNWEEPEYD GGSPVTGYWL 
EMKDTTSKRW KRVNRDPIKA MTLGVSYKVT GLIEGSDYQF RVYAINAAGV GPASLPSDPA 
TARDPIAPPG PPFPKVTDWT KSSADLEWSP PLKDGGSKVT GYIVEYKEEG KEEWEKGKDK 
EVRGTKLVVT GLKEGAFYKF RVRAVNIAGI GEPGEVTDVI EMKDRLVSPD LQLDASVRDR 
IVVHAGGVIR IIAYVSGKPP PTVTWNMNER TLPQEATIET TAISSSMVIK NCQRSHQGVY 
SLLAKNEAGE RKKTIIVDVL DVPGPVGTPF LAHNLTNESC KLTWFSPEDD GGSPITNYVI 
EKRESDRRAW TPVTYTVTRQ NATVQGLIQG KAYFFRIAAE NSIGMGPFVE TSEALVIREP 
ITVPERPEDL EVKEVTKNTV TLTWNPPKYD GGSEIINYVL ESRLIGTEKF HKVTNDNLLS 
RKYTVKGLKE GDTYEYRVSA VNIVGQGKPS FCTKPITCKD ELAPPTLHLD FRDKLTIRVG 
EAFALTGRYS GKPKPKVSWF KDEADVLEDD RTHIKTTPAT LALEKIKAKR SDSGKYCVVV 
ENSTGSRKGF CQVNVVDRPG PPVGPVSFDE VTKDYMVISW KPPLDDGGSK ITNYIIEKKE 
VGKDVWMPVT SASAKTTCKV SKLLEGKDYI FRIHAENLYG ISDPLVSDSM KAKDRFRVPD 
APDQPIVTEV TKDSALVTWN KPHDGGKPIT NYILEKRETM SKRWARVTKD PIHPYTKFRV 
PDLLEGCQYE FRVSAENEIG IGDPSPPSKP VFAKDPIAKP SPPVNPEAID TTCNSVDLTW 
QPPRHDGGSK ILGYIVEYQK VGDEEWRRAN HTPESCPETK YKVTGLRDGQ TYKFRVLAVN 
AAGESDPAHV PEPVLVKDRL EPPELILDAN MAREQHIKVG DTLRLSAIIK GVPFPKVTWK 
KEDRDAPTKA RIDVTPVGSK LEIRNAAHED GGIYSLTVEN PAGSKTVSVK VLVLDKPGPP 
RDLEVSEIRK DSCYLTWKEP LDDGGSVITN YVVERRDVAS AQWSPLSATS KKKSHFAKHL 
NEGNQYLFRV AAENQYGRGP FVETPKPIKA LDPLHPPGPP KDLHHVDVDK TEVSLVWNKP 
DRDGGSPITG YLVEYQEEGT QDWIKFKTVT NLECVVTGLQ QGKTYRFRVK AENIVGLGLP 
DTTIPIECQE KLVPPSVELD VKLIEGLVVK AGTTVRFPAI IRGVPVPTAK WTTDGSEIKT 
DEHYTVETDN FSSVLTIKNC LRRDTGEYQI TVSNAAGSKT VAVHLTVLDV PGPPTGPINI 
LDVTPEHMTI SWQPPKDDGG SPVINYIVEK QDTRKDTWGV VSSGSSKTKL KIPHLQKGCE 
YVFRVRAENK IGVGPPLDST PTVAKHKFSP PSPPGKPVVT DITENAATVS WTLPKSDGGS 
PITGYYMERR EVTGKWVRVN KTPIADLKFR VTGLYEGNTY EFRVFAENLA GLSKPSPSSD 
PIKACRPIKP PGPPINPKLK DKSRETADLV WTKPLSDGGS PILGYVVECQ KPGTAQWNRI 
NKDELIRQCA FRVPGLIEGN EYRFRIKAAN IVGEGEPREL AESVIAKDIL HPPEVELDVT 
CRDVITVRVG QTIRILARVK GRPEPDITWT KEGKVLVREK RVDLIQDLPR VELQIKEAVR 
ADHGKYIISA KNSSGHAQGS AIVNVLDRPG PCQNLKVTNV TKENCTISWE NPLDNGGSEI 
TNFIVEYRKP NQKGWSIVAS DVTKRLIKAN LLANNEYYFR VCAENKVGVG PTIETKTPIL 
AINPIDRPGE PENLHIADKG KTFVYLKWRR PDYDGGSPNL SYHVERRLKG SDDWERVHKG 
SIKETHYMVD RCVENQIYEF RVQTKNEGGE SDWVKTEEVV VKEDLQKPVL DLKLSGVLTV 
KAGDTIRLEA GVRGKPFPEV AWTKDKDATD LTRSPRVKID TRADSSKFSL TKAKRSDGGK 
YVVTATNTAG SFVAYATVNV LDKPGPVRNL KIVDVSSDRC TVCWDPPEDD GGCEIQNYIL 
EKCETKRMVW STYSATVLTP GTTVTRLIEG NEYIFRVRAE NKIGTGPPTE SKPVIAKTKY 
DKPGRPDPPE VTKVSKEEMT VVWNPPEYDG GKSITGYFLE KKEKHSTRWV PVNKSAIPER 
RMKVQNLLPD HEYQFRVKAE NEIGIGEPSL PSRPVVAKDP IEPPGPPTNF RVVDTTKHSI 
TLGWGKPVYD GGAPIIGYVV EMRPKIADAS PDEGWKRCNA AAQLVRKEFT VTSLDENQEY 
EFRVCAQNQV GIGRPAELKE AIKPKEILEP PEIDLDASMR KLVIVRAGCP IRLFAIVRGR 
PAPKVTWRKV GIDNVVRKGQ VDLVDTMAFL VIPNSTRDDS GKYSLTLVNP AGEKAVFVNV 
RVLDTPGPVS DLKVSDVTKT SCHVSWAPPE NDGGSQVTHY IVEKREADRK TWSTVTPEVK 
KTSFHVTNLV PGNEYYFRVT AVNEYGPGVP TDVPKPVLAS DPLSEPDPPR KLEVTEMTKN 
SATLAWLPPL RDGGAKIDGY ITSYREEEQP ADRWTEYSVV KDLSLVVTGL KEGKKYKFRV 
AARNAVGVSL PREAEGVYEA KEQLLPPKIL MPEQITIKAG KKLRIEAHVY GKPHPTCKWK 
KGEDEVVTSS HLAVHKADSS SILIIKDVTR KDSGYYSLTA ENSSGTDTQK IKVVVMDAPG 
PPQPPFDISD IDADACSLSW HIPLEDGGSN ITNYIVEKCD VSRGDWVTAL ASVTKTSCRV 
GKLIPGQEYI FRVRAENRFG ISEPLTSPKM VAQFPFGVPS EPKNARVTKV NKDCIFVAWD 
RPDSDGGSPI IGYLIERKER NSLLWVKAND TLVRSTEYPC AGLVEGLEYS FRIYALNKAG 
SSPPSKPTEY VTARMPVDPP GKPEVIDVTK STVSLIWARP KHDGGSKIIG YFVEACKLPG 
DKWVRCNTAP HQIPQEEYTA TGLEEKAQYQ FRAIARTAVN ISPPSEPSDP VTILAENVPP 
RIDLSVAMKS LLTVKAGTNV CLDATVFGKP MPTVSWKKDG TLLKPAEGIK MAMQRNLCTL 
ELFSVNRKDS GDYTITAENS SGSKSATIKL KVLDKPGPPA SVKINKMYSD RAMLSWEPPL 
EDGGSEITNY IVDKRETSRP NWAQVSATVP ITSCSVEKLI EGHEYQFRIC AENKYGVGDP 
VFTEPAIAKN PYDPPGRCDP PVISNITKDH MTVSWKPPAD DGGSPITGYL LEKRETQAVN 
WTKVNRKPII ERTLKATGLQ EGTEYEFRVT AINKAGPGKP SDASKAAYAR DPQYPPGPPA 
FPKVYDTTRS SVSLSWGKPA YDGGSPIIGY LVEVKRADSD NWVRCNLPQN LQKTRFEVTG 
LMEDTQYQFR VYAVNKIGYS DPSDVPDKHY PKDILIPPEG ELDADLRKTL ILRAGVTMRL 
YVPVKGRPPP KITWSKPNVN LRDRIGLDIK STDFDTFLRC ENVNKYDAGK YILTLENSCG 
KKEYTIVVKV LDTPGPPVNV TVKEISKDSA YVTWEPPIID GGSPIINYVV QKRDAERKSW 
STVTTECSKT SFRVANLEEG KSYFFRVFAE NEYGIGDPGE TRDAVKASQT PGPVVDLKVR 
SVSKSSCSIG WKKPHSDGGS RIIGYVVDFL TEENKWQRVM KSLSLQYSAK DLTEGKEYTF 
RVSAENENGE GTPSEITVVA RDDVVAPDLD LKGLPDLCYL AKENSNFRLK IPIKGKPAPS 
VSWKKGEDPL ATDTRVSVES SAVNTTLIVY DCQKSDAGKY TITLKNVAGT KEGTISIKVV 
GKPGIPTGPI KFDEVTAEAM TLKWAPPKDD GGSEITNYIL EKRDSVNNKW VTCASAVQKT 
TFRVTRLHEG MEYTFRVSAE NKYGVGEGLK SEPIVARHPF DVPDAPPPPN IVDVRHDSVS 
LTWTDPKKTG GSPITGYHLE FKERNSLLWK RANKTPIRMR DFKVTGLTEG LEYEFRVMAI 
NLAGVGKPSL PSEPVVALDP IDPPGKPEVI NITRNSVTLI WTEPKYDGGH KLTGYIVEKR 
DLPSKSWMKA NHVNVPECAF TVTDLVEGGK YEFRIRAKNT AGAISAPSES TETIICKDEY 
EAPTIVLDPT IKDGLTIKAG DTIVLNAISI LGKPLPKSSW SKAGKDIRPS DITQITSTPT 
SSMLTIKYAT RKDAGEYTIT ATNPFGTKVE HVKVTVLDVP GPPGPVEISN VSAEKATLTW 
TPPLEDGGSP IKSYILEKRE TSRLLWTVVS EDIQSCRHVA TKLIQGNEYI FRVSAVNHYG 
KGEPVQSEPV KMVDRFGPPG PPEKPEVSNV TKNTATVSWK RPVDDGGSEI TGYHVERREK 
KSLRWVRAIK TPVSDLRCKV TGLQEGSTYE FRVSAENRAG IGPPSEASDS VLMKDAAYPP 
GPPSNPHVTD TTKKSASLAW GKPHYDGGLE ITGYVVEHQK VGDEAWIKDT TGTALRITQF 
VVPDLQTKEK YNFRISAIND AGVGEPAVIP DVEIVEREMA PDFELDAELR RTLVVRAGLS 
IRIFVPIKGR PAPEVTWTKD NINLKNRANI ENTESFTLLI IPECNRYDTG KFVMTIENPA 
GKKSGFVNVR VLDTPGPVLN LRPTDITKDS VTLHWDLPLI DGGSRITNYI VEKREATRKS 
YSTATTKCHK CTYKVTGLSE GCEYFFRVMA ENEYGIGEPT ETTEPVKASE APSPPDSLNI 
MDITKSTVSL AWPKPKHDGG SKITGYVIEA QRKGSDQWTH ITTVKGLECV VRNLTEGEEY 
TFQVMAVNSA GRSAPRESRP VIVKEQTMLP ELDLRGIYQK LVIAKAGDNI KVEIPVLGRP 
KPTVTWKKGD QILKQTQRVN FETTATSTIL NINECVRSDS GPYPLTARNI VGEVGDVITI 
QVHDIPGPPT GPIKFDEVSS DFVTFSWDPP ENDGGVPISN YVVEMRQTDS TTWVELATTV 
IRTTYKATRL TTGLEYQFRV KAQNRYGVGP GITSACIVAN YPFKVPGPPG TPQVTAVTKD 
SMTISWHEPL SDGGSPILGY HVERKERNGI LWQTVSKALV PGNIFKSSGL TDGIAYEFRV 
IAENMAGKSK PSKPSEPMLA LDPIDPPGKP VPLNITRHTV TLKWAKPEYT GGFKITSYIV 
EKRDLPNGRW LKANFSNILE NEFTVSGLTE DAAYEFRVIA KNAAGAISPP SEPSDAITCR 
DDVEAPKIKV DVKFKDTVIL KAGEAFRLEA DVSGRPPPTM EWSKDGKELE GTAKLEIKIA 
DFSTNLVNKD STRRDSGAYT LTATNPGGFA KHIFNVKVLD RPGPPEGPLA VTEVTSEKCV 
LSWFPPLDDG GAKIDHYIVQ KRETSRLAWT NVASEVQVTK LKVTKLLKGN EYIFRVMAVN 
KYGVGEPLES EPVLAVNPYG PPDPPKNPEV TTITKDSMVV CWGHPDSDGG SEIINYIVER 
RDKAGQRWIK CNKKTLTDLR YKVSGLTEGH EYEFRIMAEN AAGISAPSPT SPFYKACDTV 
FKPGPPGNPR VLDTSRSSIS IAWNKPIYDG GSEITGYMVE IALPEEDEWQ IVTPPAGLKA 
TSYTITGLTE NQEYKIRIYA MNSEGLGEPA LVPGTPKAED RMLPPEIELD ADLRKVVTIR 
ACCTLRLFVP IKGRPAPEVK WARDHGESLD KASIESTSSY TLLIVGNVNR FDSGKYILTV 
ENSSGSKSAF VNVRVLDTPG PPQDLKVKEV TKTSVTLTWD PPLLDGGSKI KNYIVEKRES 
TRKAYSTVAT NCHKTSWKVD QLQEGCSYYF RVLAENEYGI GLPAETAESV KASERPLPPG 
KITLMDVTRN SVSLSWEKPE HDGGSRILGY IVEMQTKGSD KWATCATVKV TEATITGLIQ 
GEEYSFRVSA QNEKGISDPR QLSVPVIAKD LVIPPAFKLL FNTFTVLAGE DLKVDVPFIG 
RPTPAVTWHK DNVPLKQTTR VNAESTENNS LLTIKDACRE DVGHYVVKLT NSAGEAIETL 
NVIVLDKPGP PTGPVKMDEV TADSITLSWG PPKYDGGSSI NNYIVEKRDT STTTWQIVSA 
TVARTTIKAC RLKTGCEYQF RIAAENRYGK STYLNSEPTV AQYPFKVPGP PGTPVVTLSS 
RDSMEVQWNE PISDGGSRVI GYHLERKERN SILWVKLNKT PIPQTKFKTT GLEEGVEYEF 
RVSAENIVGI GKPSKVSECY VARDPCDPPG RPEAIIVTRN SVTLQWKKPT YDGGSKITGY 
IVEKKELPEG RWMKASFTNI IDTHFEVTGL VEDHRYEFRV IARNAAGVFS EPSESTGAIT 
ARDEVDPPRI SMDPKYKDTI VVHAGESFKV DADIYGKPIP TIQWIKGDQE LSNTARLEIK 
STDFATSLSV KDAVRVDSGN YILKAKNVAG ERSVTVNVKV LDRPGPPEGP VVISGVTAEK 
CTLAWKPPLQ DGGSDIINYI VERRETSRLV WTVVDANVQT LSCKVTKLLE GNEYTFRIMA 
VNKYGVGEPL ESEPVVAKNP FVVPDAPKAP EVTTVTKDSM IVVWERPASD GGSEILGYVL 
EKRDKEGIRW TRCHKRLIGE LRLRVTGLIE NHDYEFRVSA ENAAGLSEPS PPSAYQKACD 
PIYKPGPPNN PKVIDITRSS VFLSWSKPIY DGGCEIQGYI VEKCDVSVGE WTMCTPPTGI 
NKTNIEVEKL LEKHEYNFRI CAINKAGVGE HADVPGPIIV EEKLEAPDID LDLELRKIIN 
IRAGGSLRLF VPIKGRPTPE VKWGKVDGEI RDAAIIDVTS SFTSLVLDNV NRYDSGKYTL 
TLENSSGTKS AFVTVRVLDT PSPPVNLKVT EITKDSVSIT WEPPLLDGGS KIKNYIVEKR 
EATRKSYAAV VTNCHKNSWK IDQLQEGCSY YFRVTAENEY GIGLPAQTAD PIKVAEVPQP 
PGKITVDDVT RNSVSLSWTK PEHDGGSKII QYIVEMQAKH SEKWSECARV KSLQAVITNL 
TQGEEYLFRV VAVNEKGRSD PRSLAVPIVA KDLVIEPDVK PAFSSYSVQV GQDLKIEVPI 
SGRPKPTITW TKDGLPLKQT TRINVTDSLD LTTLSIKETH KDDGGQYGIT VANVVGQKTA 
SIEIVTLDKP DPPKGPVKFD DVSAESITLS WNPPLYTGGC QITNYIVQKR DTTTTVWDVV 
SATVARTTLK VTKLKTGTEY QFRIFAENRY GQSFALESDP IVAQYPYKEP GPPGTPFATA 
ISKDSMVIQW HEPVNNGGSP VIGYHLERKE RNSILWTKVN KTIIHDTQFK AQNLEEGIEY 
EFRVYAENIV GVGKASKNSE CYVARDPCDP PGTPEPIMVK RNEITLQWTK PVYDGGSMIT 
GYIVEKRDLP DGRWMKASFT NVIETQFTVS GLTEDQRYEF RVIAKNAAGA ISKPSDSTGP 
ITAKDEVELP RISMDPKFRD TIVVNAGETF RLEADVHGKP LPTIEWLRGD KEIEESARCE 
IKNTDFKALL IVKDAIRIDG GQYILRASNV AGSKSFPVNV KVLDRPGPPE GPVQVTGVTS 
EKCSLTWSPP LQDGGSDISH YVVEKRETSR LAWTVVASEV VTNSLKVTKL LEGNEYVFRI 
MAVNKYGVGE PLESAPVLMK NPFVLPGPPK SLEVTNIAKD SMTVCWNRPD SDGGSEIIGY 
IVEKRDRSGI RWIKCNKRRI TDLRLRVTGL TEDHEYEFRV SAENAAGVGE PSPATVYYKA 
CDPVFKPGPP TNAHIVDTTK NSITLAWGKP IYDGGSEILG YVVEICKADE EEWQIVTPQT 
GLRVTRFEIS KLTEHQEYKI RVCALNKVGL GEATSVPGTV KPEDKLEAPE LDLDSELRKG 
IVVRAGGSAR IHIPFKGRPT PEITWSREEG EFTDKVQIEK GVNYTQLSID NCDRNDAGKY 
ILKLENSSGS KSAFVTVKVL DTPGPPQNLA VKEVRKDSAF LVWEPPIIDG GAKVKNYVID 
KRESTRKAYA NVSSKCSKTS FKVENLTEGA IYYFRVMAEN EFGVGVPVET VDAVKAAEPP 
SPPGKVTLTD VSQTSASLMW EKPEHDGGSR VLGYVVEMQP KGTEKWSIVA ESKVCNAVVT 
GLSSGQEYQF RVKAYNEKGK SDPRVLGVPV IAKDLTIQPS LKLPFNTYSI QAGEDLKIEI 
PVIGRPRPNI SWVKDGEPLK QTTRVNVEET ATSTVLHIKE GNKDDFGKYT VTATNSAGTA 
TENLSVIVLE KPGPPVGPVR FDEVSADFVV ISWEPPAYTG GCQISNYIVE KRDTTTTTWH 
MVSATVARTT IKITKLKTGT EYQFRIFAEN RYGKSAPLDS KAVIVQYPFK EPGPPGTPFV 
TSISKDQMLV QWHEPVNDGG TKIIGYHLEQ KEKNSILWVK LNKTPIQDTK FKTTGLDEGL 
EYEFKVSAEN IVGIGKPSKV SECFVARDPC DPPGRPEAIV ITRNNVTLKW KKPAYDGGSK 
ITGYIVEKKD LPDGRWMKAS FTNVLETEFT VSGLVEDQRY EFRVIARNAA GNFSEPSDSS 
GAITARDEID APNASLDPKY KDVIVVHAGE TFVLEADIRG KPIPDVVWSK DGKELEETAA 
RMEIKSTIQK TTLVVKDCIR TDGGQYILKL SNVGGTKSIP ITVKVLDRPG PPEGPLKVTG 
VTAEKCYLAW NPPLQDGGAN ISHYIIEKRE TSRLSWTQVS TEVQALNYKV TKLLPGNEYI 
FRVMAVNKYG IGEPLESGPV TACNPYKPPG PPSTPEVSAI TKDSMVVTWA RPVDDGGTEI 
EGYILEKRDK EGVRWTKCNK KTLTDLRLRV TGLTEGHSYE FRVAAENAAG VGEPSEPSVF 
YRACDALYPP GPPSNPKVTD TSRSSVSLAW SKPIYDGGAP VKGYVVEVKE AAADEWTTCT 
PPTGLQGKQF TVTKLKENTE YNFRICAINS EGVGEPATLP GSVVAQERIE PPEIELDADL 
RKVVVLRASA TLRLFVTIKG RPEPEVKWEK AEGILTDRAQ IEVTSSFTML VIDNVTRFDS 
GRYNLTLENN SGSKTAFVNV RVLDSPSAPV NLTIREVKKD SVTLSWEPPL IDGGAKITNY 
IVEKRETTRK AYATITNNCT KTTFRIENLQ EGCSYYFRVL ASNEYGIGLP AETTEPVKVS 
EPPLPPGRVT LVDVTRNTAT IKWEKPESDG GSKITGYVVE MQTKGSEKWS TCTQVKTLEA 
TISGLTAGEE YVFRVAAVNE KGRSDPRQLG VPVIARDIEI KPSVELPFHT FNVKAREQLK 
IDVPFKGRPQ ATVNWRKDGQ TLKETTRVNV SSSKTVTSLS IKEASKEDVG TYELCVSNSA 
GSITVPITII VLDRPGPPGP IRIDEVSCDS ITISWNPPEY DGGCQISNYI VEKKETTSTT 
WHIVSQAVAR TSIKIVRLTT GSEYQFRVCA ENRYGKSSYS ESSAVVAEYP FSPPGPPGTP 
KVVHATKSTM LVTWQVPVND GGSRVIGYHL EYKERSSILW SKANKILIAD TQMKVSGLDE 
GLMYEYRVYA ENIAGIGKCS KSCEPVPARD PCDPPGQPEV TNITRKSVSL KWSKPHYDGG 
AKITGYIVER RELPDGRWLK CNYTNIQETY FEVTELTEDQ RYEFRVFARN AADSVSEPSE 
STGPIIVKDD VEPPRVMMDV KFRDVIVVKA GEVLKINADI AGRPLPVISW AKDGIEIEER 
ARTEIISTDN HTLLTVKDCI RRDTGQYVLT LKNVAGTRSV AVNCKVLDKP GPPAGPLEIN 
GLTAEKCSLS WGRPQEDGGA DIDYYIVEKR ETSHLAWTIC EGELQMTSCK VTKLLKGNEY 
IFRVTGVNKY GVGEPLESVA IKALDPFTVP SPPTSLEITS VTKESMTLCW SRPESDGGSE 
ISGYIIERRE KNSLRWVRVN KKPVYDLRVK STGLREGCEY EYRVYAENAA GLSLPSETSP 
LIRAEDPVFL PSPPSKPKIV DSGKTTITIA WVKPLFDGGA PITGYTVEYK KSDDTDWKTS 
IQSLRGTEYT ISGLTTGAEY VFRVKSVNKV GASDPSDSSD PQIAKEREEE PLFDIDSEMR 
KTLIVKAGAS FTMTVPFRGR PVPNVLWSKP DTDLRTRAYV DTTDSRTSLT IENANRNDSG 
KYTLTIQNVL SAASLTLVVK VLDTPGPPTN ITVQDVTKES AVLSWDVPEN DGGAPVKNYH 
IEKREASKKA WVSVTNNCNR LSYKVTNLQE GAIYYFRVSG ENEFGVGIPA ETKEGVKITE 
KPSPPEKLGV TSISKDSVSL TWLKPEHDGG SRIVHYVVEA LEKGQKNWVK CAVAKSTHHV 
VSGLRENSEY FFRVFAENQA GLSDPRELLL PVLIKEQLEP PEIDMKNFPS HTVYVRAGSN 
LKVDIPISGK PLPKVTLSRD GVPLKATMRF NTEITAENLT INLKESVTAD AGRYEITAAN 
SSGTTKAFIN IVVLDRPGPP TGPVVISDIT EESVTLKWEP PKYDGGSQVT NYILLKRETS 
TAVWTEVSAT VARTMMKVMK LTTGEEYQFR IKAENRFGIS DHIDSACVTV KLPYTTPGPP 
STPWVTNVTR ESITVGWHEP VSNGGSAVVG YHLEMKDRNS ILWQKANKLV IRTTHFKVTT 
ISAGLIYEFR VYAENAAGVG KPSHPSEPVL AIDACEPPRN VRITDISKNS VSLSWQQPAF 
DGGSKITGYI VERRDLPDGR WTKASFTNVT ETQFIISGLT QNSQYEFRVF ARNAVGSISN 
PSEVVGPITC IDSYGGPVID LPLEYTEVVK YRAGTSVKLR AGISGKPAPT IEWYKDDKEL 
QTNALVCVEN TTDLASILIK DADRLNSGCY ELKLRNAMGS ASATIRVQIL DKPGPPGGPI 
EFKTVTAEKI TLLWRPPADD GGAKITHYIV EKRETSRVVW SMVSEHLEEC IITTTKIIKG 
NEYIFRVRAV NKYGIGEPLE SDSVVAKNAF VTPGPPGIPE VTKITKNSMT VVWSRPIADG 
GSDISGYFLE KRDKKSLGWF KVLKETIRDT RQKVTGLTEN SDYQYRVCAV NAAGQGPFSE 
PSEFYKAADP IDPPGPPAKI RIADSTKSSI TLGWSKPVYD GGSAVTGYVV EIRQGEEEEW 
TTVSTKGEVR TTEYVVSNLK PGVNYYFRVS AVNCAGQGEP IEMNEPVQAK DILEAPEIDL 
DVALRTSVIA KAGEDVQVLI PFKGRPPPTV TWRKDEKNLG SDARYSIENT DSSSLLTIPQ 
VTRNDTGKYI LTIENGVGEP KSSTVSVKVL DTPAACQKLQ VKHVSRGTVT LLWDPPLIDG 
GSPIINYVIE KRDATKRTWS VVSHKCSSTS FKLIDLSEKT PFFFRVLAEN EIGIGEPCET 
TEPVKAAEVP APIRDLSMKD STKTSVILSW TKPDFDGGSV ITEYVVERKG KGEQTWSHAG 
ISKTCEIEVS QLKEQSVLEF RVFAKNEKGL SDPVTIGPIT VKELIITPEV DLSDIPGAQV 
TVRIGHNVHL ELPYKGKPKP SISWLKDGLP LKESEFVRFS KTENKITLSI KNAKKEHGGK 
YTVILDNAVC RIAVPITVIT LGPPSKPKGP IRFDEIKADS VILSWDVPED NGGGEITCYS 
IEKRETSQTN WKMVCSSVAR TTFKVPNLVK DAEYQFRVRA ENRYGVSQPL VSSIIVAKHQ 
FRIPGPPGKP VIYNVTSDGM SLTWDAPVYD GGSEVTGFHV EKKERNSILW QKVNTSPISG 
REYRATGLVE GLDYQFRVYA ENSAGLSSPS DPSKFTLAVS PVDPPGTPDY IDVTRETITL 
KWNPPLRDGG SKIVGYSIEK RQGNERWVRC NFTDVSECQY TVTGLSPGDR YEFRIIARNA 
VGTISPPSQS SGIIMTRDEN VPPIVEFGPE YFDGLIIKSG ESLRIKALVQ GRPVPRVTWF 
KDGVEIEKRM NMEITDVLGS TSLFVRDATR DHRGVYTVEA KNASGSAKAE IKVKVQDTPG 
KVVGPIRFTN ITGEKMTLWW DAPLNDGCAP ITHYIIEKRE TSRLAWALIE DKCEAQSYTA 
IKLINGNEYQ FRVSAVNKFG VGRPLDSDPV VAQIQYTVPD APGIPEPSNI TGNSITLTWA 
RPESDGGSEI QQYILERREK KSTRWVKVIS KRPISETRFK VTGLTEGNEY EFHVMAENAA 
GVGPASGISR LIKCREPVNP PGPPTVVKVT DTSKTTVSLE WSKPVFDGGM EIIGYIIEMC 
KADLGDWHKV NAEACVKTRY TVTDLQAGEE YKFRVSAING AGKGDSCEVT GTIKAVDRLT 
APELDIDANF KQTHVVRAGA SIRLFIAYQG RPTPTAVWSK PDSNLSLRAD IHTTDSFSTL 
TVENCNRNDA GKYTLTVENN SGSKSITFTV KVLDTPGPPG PITFKDVTRG SATLMWDAPL 
LDGGARIHHY VVEKREASRR SWQVISEKCT RQIFKVNDLA EGVPYYFRVS AVNEYGVGEP 
YEMPEPIVAT EQPAPPRRLD VVDTSKSSAV LAWLKPDHDG GSRITGYLLE MRQKGSDFWV 
EAGHTKQLTF TVERLVEKTE YEFRVKAKND AGYSEPREAF SSVIIKEPQI EPTADLTGIT 
NQLITCKAGS PFTIDVPISG RPAPKVTWKL EEMRLKETDR VSITTTKDRT TLTVKDSMRG 
DSGRYFLTLE NTAGVKTFSV TVVVIGRPGP VTGPIEVSSV SAESCVLSWG EPKDGGGTEI 
TNYIVEKRES GTTAWQLVNS SVKRTQIKVT HLTKYMEYSF RVSSENRFGV SKPLESAPII 
AEHPFVPPSA PTRPEVYHVS ANAMSIRWEE PYHDGGSKII GYWVEKKERN TILWVKENKV 
PCLECNYKVT GLVEGLEYQF RTYALNAAGV SKASEASRPI MAQNPVDAPG RPEVTDVTRS 
TVSLIWSAPA YDGGSKVVGY IIERKPVSEV GDGRWLKCNY TIVSDNFFTV TALSEGDTYE 
FRVLAKNAAG VISKGSESTG PVTCRDEYAP PKAELDARLH GDLVTIRAGS DLVLDAAVGG 
KPEPKIIWTK GDKELDLCEK VSLQYTGKRA TAVIKFCDRS DSGKYTLTVK NASGTKAVSV 
MVKVLDSPGP CGKLTVSRVT QEKCTLAWSL PQEDGGAEIT HYIVERRETS RLNWVIVEGE 
CPTLSYVVTR LIKNNEYIFR VRAVNKYGPG VPVESEPIVA RNSFTIPSPP GIPEEVGTGK 
EHIIIQWTKP ESDGGNEISN YLVDKREKKS LRWTRVNKDY VVYDTRLKVT SLMEGCDYQF 
RVTAVNAAGN SEPSEASNFI SCREPSYTPG PPSAPRVVDT TKHSISLAWT KPMYDGGTDI 
VGYVLEMQEK DTDQWYRVHT NATIRNTEFT VPDLKMGQKY SFRVAAVNVK GMSEYSESIA 
EIEPVERIEI PDLELADDLK KTVTIRAGAS LRLMVSVSGR PPPVITWSKQ GIDLASRAII 
DTTESYSLLI VDKVNRYDAG KYTIEAENQS GKKSATVLVK VYDTPGPCPS VKVKEVSRDS 
VTITWEIPTI DGGAPVNNYI VEKREAAMRA FKTVTTKCSK TLYRISGLVE GTMYYFRVLP 
ENIYGIGEPC ETSDAVLVSE VPLVPAKLEV VDVTKSTVTL AWEKPLYDGG SRLTGYVLEA 
CKAGTERWMK VVTLKPTVLE HTVTSLNEGE QYLFRIRAQN EKGVSEPRET VTAVTVQDLR 
VLPTIDLSTM PQKTIHVPAG RPVELVIPIA GRPPPAASWF FAGSKLRESE RVTVETHTKV 
AKLTIRETTI RDTGEYTLEL KNVTGTTSET IKVIILDKPG PPTGPIKIDE IDATSITISW 
EPPELDGGAP LSGYVVEQRD AHRPGWLPVS ESVTRSTFKF TRLTEGNEYV FRVAATNRFG 
IGSYLQSEVI ECRSSIRIPG PPETLQIFDV SRDGMTLTWY PPEDDGGSQV TGYIVERKEV 
RADRWVRVNK VPVTMTRYRS TGLTEGLEYE HRVTAINARG SGKPSRPSKP IVAMDPIAPP 
GKPQNPRVTD TTRTSVSLAW SVPEDEGGSK VTGYLIEMQK VDQHEWTKCN TTPTKIREYT 
LTHLPQGAEY RFRVLACNAG GPGEPAEVPG TVKVTEMLEY PDYELDERYQ EGIFVRQGGV 
IRLTIPIKGK PFPICKWTKE GQDISKRAMI ATSETHTELV IKEADRGDSG TYDLVLENKC 
GKKAVYIKVR VIGSPNSPEG PLEYDDIQVR SVRVSWRPPA DDGGADILGY ILERREVPKA 
AWYTIDSRVR GTSLVVKGLK ENVEYHFRVS AENQFGISKP LKSEEPVTPK TPLNPPEPPS 
NPPEVLDVTK SSVSLSWSRP KDDGGSRVTG YYIERKETST DKWVRHNKTQ ITTTMYTVTG 
LVPDAEYQFR IIAQNDVGLS ETSPASEPVV CKDPFDKPSQ PGELEILSIS KDSVTLQWEK 
PECDGGKEIL GYWVEYRQSG DSAWKKSNKE RIKDKQFTIG GLLEATEYEF RVFAENETGL 
SRPRRTAMSI KTKLTSGEAP GIRKEMKDVT TKLGEAAQLS CQIVGRPLPD IKWYRFGKEL 
IQSRKYKMSS DGRTHTLTVM TEEQEDEGVY TCIATNEVGE VETSSKLLLQ ATPQFHPGYP 
LKEKYYGAVG STLRLHVMYI GRPVPAMTWF HGQKLLQNSE NITIENTEHY THLVMKNVQR 
KTHAGKYKVQ LSNVFGTVDA ILDVEIQDKP DKPTGPIVIE ALLKNSAVIS WKPPADDGGS 
WITNYVVEKC EAKEGAEWQL VSSAISVTTC RIVNLTENAG YYFRVSAQNT FGISDPLEVS 
SVVIIKSPFE KPGAPGKPTI TAVTKDSCVV AWKPPASDGG AKIRNYYLEK REKKQNKWIS 
VTTEEIRETV FSVKNLIEGL EYEFRVKCEN LGGESEWSEI SEPITPKSDV PIQAPHFKEE 
LRNLNVRYQS NATLVCKVTG HPKPIVKWYR QGKEIIADGL KYRIQEFKGG YHQLIIASVT 
DDDATVYQVR ATNQGGSVSG TASLEVEVPA KIHLPKTLEG MGAVHALRGE VVSIKIPFSG 
KPDPVITWQK GQDLIDNNGH YQVIVTRSFT SLVFPNGVER KDAGFYVVCA KNRFGIDQKT 
VELDVADVPD PPRGVKVSDV SRDSVNLTWT EPASDGGSKI TNYIVEKCAT TAERWLRVGQ 
ARETRYTVIN LFGKTSYQFR VIAENKFGLS KPSEPSEPTI TKEDKTRAMN YDEEVDETRE 
VSMTKASHSS TKELYEKYMI AEDLGRGEFG IVHRCVETSS KKTYMAKFVK VKGTDQVLVK 
KEISILNIAR HRNILHLHES FESMEELVMI FEFISGLDIF ERINTSAFEL NEREIVSYVH 
QVCEALQFLH SHNIGHFDIR PENIIYQTRR SSTIKIIEFG QARQLKPGDN FRLLFTAPEY 
YAPEVHQHDV VSTATDMWSL GTLVYVLLSG INPFLAETNQ QIIENIMNAE YTFDEEAFKE 
ISIEAMDFVD RLLVKERKSR MTASEALQHP WLKQKIERVS TKVIRTLKHR RYYHTLIKKD 
LNMVVSAARI SCGGAIRSQK GVSVAKVKVA SIEIGPVSGQ IMHAVGEEGG HVKYVCKIEN 
YDQSTQVTWY FGVRQLENSE KYEITYEDGV AILYVKDITK LDDGTYRCKV VNDYGEDSSY 
AELFVKGVRE VYDYYCRRTM KKIKRRTDTM RLLERPPEFT LPLYNKTAYV GENVRFGVTI 
TVHPEPHVTW YKSGQKIKPG DNDKKYTFES DKGLYQLTIN SVTTDDDAEY TVVARNKYGE 
DSCKAKLTVT LHPPPTDSTL RPMFKRLLAN AECQEGQSVC FEIRVSGIPP PTLKWEKDGQ 
PLSLGPNIEI IHEGLDYYAL HIRDTLPEDT GYYRVTATNT AGSTSCQAHL QVERLRYKKQ 
EFKSKEEHER HVQKQIDKTL RMAEILSGTE SVPLTQVAKE ALREAAVLYK PAVSTKTVKG 
EFRLEIEEKK EERKLRMPYD VPEPRKYKQT TIEEDQRIKQ FVPMSDMKWY KKIRDQYEMP 
GKLDRVVQKR PKRIRLSRWE QFYVMPLPRI TDQYRPKWRI PKLSQDDLEI VRPARRRTPS 
PDYDFYYRPR RRSLGDISDE ELLLPIDDYL AMKRTEEERL RLEEELELGF SASPPSRSPP 
HFELSSLRYS SPQAHVKVEE TRKDFRYSTY HIPTKAEAST SYAELRERHA QAAYRQPKQR 
QRIMAEREDE ELLRPVTTTQ HLSEYKSELD FMSKEEKSRK KSRRQREVTE ITEIEEEYEI 
SKHAQRESSS SASRLLRRRR SLSPTYIELM RPVSELIRSR PQPAEEYEDD TERRSPTPER 
TRPRSPSPVS SERSLSRFER SARFDIFSRY ESMKAALKTQ KTSERKYEVL SQQPFTLDHA 
PRITLRMRSH RVPCGQNTRF ILNVQSKPTA EVKWYHNGVE LQESSKIHYT NTSGVLTLEI 
LDCHTDDSGT YRAVCTNYKG EASDYATLDV TGGDYTTYAS QRRDEEVPRS VFPELTRTEA 
YAVSSFKKTS EMEASSSVRE VKSQMTETRE SLSSYEHSAS AEMKSAALEE KSLEEKSTTR 
KIKTTLAARI LTKPRSMTVY EGESARFSCD TDGEPVPTVT WLRKGQVLST SARHQVTTTK 
YKSTFEISSV QASDEGNYSV VVENSEGKQE AEFTLTIQKA RVTEKAVTSP PRVKSPEPRV 
KSPEAVKSPK RVKSPEPSHP KAVSPTETKP TPTEKVQHLP VSAPPKITQF LKAEASKEIA 
KLTCVVESSV LRAKEVTWYK DGKKLKENGH FQFHYSADGT YELKINNLTE SDQGEYVCEI 
SGEGGTSKTN LQFMGQAFKS IHEKVSKISE TKKSDQKTTE STVTRKTEPK APEPISSKPV 
IVTGLQDTTV SSDSVAKFAV KATGEPRPTA IWTKDGKAIT QGGKYKLSED KGGFFLEIHK 
TDTSDSGLYT CTVKNSAGSV SSSCKLTIKA IKDTEAQKVS TQKTSEITPQ KKAVVQEEIS 
QKALRSEEIK MSEAKSQEKL ALKEEASKVL ISEEVKKSAA TSLEKSIVHE EITKTSQASE 
EVRTHAEIKA FSTQMSINEG QRLVLKANIA GATDVKWVLN GVELTNSEEY RYGVSGSDQT 
LTIKQASHRD EGILTCISKT KEGIVKCQYD LTLSKELSDA PAFISQPRSQ NINEGQNVLF 
TCEISGEPSP EIEWFKNNLP ISISSNVSIS RSRNVYSLEI RNASVSDSGK YTIKAKNFRG 
QCSATASLMV LPLVEEPSRE VVLRTSGDTS LQGSFSSQSV QMSASKQEAS FSSFSSSSAS 
SMTEMKFASM SAQSMSSMQE SFVEMSSSSF MGISNMTQLE SSTSKMLKAG IRGIPPKIEA 
LPSDISIDEG KVLTVACAFT GEPTPEVTWS CGGRKIHSQE QGRFHIENTD DLTTLIIMDV 
QKQDGGLYTL SLGNEFGSDS ATVNIHIRSI

Genular Protein ID: 2359417532

Symbol: C9JQJ2_HUMAN

Name: N/A

UniProtKB Accession Codes:

C9JQJ2 A0A0A0MTS7

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 9 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 3 ExpressionAtlas 2 GO 4 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 16 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 4 PROSITE 4 PeptideAtlas 1 Pfam 6 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMART 4 SMR 1 SUPFAM 3 UCSC 2 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

Sequence Information:

  • Length: 35991
  • Mass: 3994655
  • Checksum: 148BA98540A862E6
  • Sequence:
    • MTTQAPTFTQ PLQSVVVLEG STATFEAHIS GFPVPEVSWF RDGQVISTST LPGVQISFSD 
GRAKLTIPAV TKANSGRYSL KATNGSGQAT STAELLVKAE TAPPNFVQRL QSMTVRQGSQ 
VRLQVRVTGI PTPVVKFYRD GAEIQSSLDF QISQEGDLYS LLIAEAYPED SGTYSVNATN 
SVGRATSTAE LLVQGEEEVP AKKTKTIVST AQISESRQTR IEKKIEAHFD ARSIATVEMV 
IDGAAGQQLP HKTPPRIPPK PKSRSPTPPS IAAKAQLARQ QSPSPIRHSP SPVRHVRAPT 
PSPVRSVSPA ARISTSPIRS VRSPLLMRKT QASTVATGPE VPPPWKQEGY VASSSEAEMR 
ETTLTTSTQI RTEERWEGRY GVQEQVTISG AAGAAASVSA SASYAAEAVA TGAKEVKQDA 
DKSAAVATVV AAVDMARVRE PVISAVEQTA QRTTTTAVHI QPAQEQVRKE AEKTAVTKVV 
VAADKAKEQE LKSRTKEVIT TKQEQMHVTH EQIRKETEKT FVPKVVISAA KAKEQETRIS 
EEITKKQKQV TQEAIRQETE ITAASMVVVA TAKSTKLETV PGAQEETTTQ QDQMHLSYEK 
IMKETRKTVV PKVIVATPKV KEQDLVSRGR EGITTKREQV QITQEKMRKE AEKTALSTIA 
VATAKAKEQE TILRTRETMA TRQEQIQVTH GKVDVGKKAE AVATVVAAVD QARVREPREP 
GHLEESYAQQ TTLEYGYKER ISAAKVAEPP QRPASEPHVV PKAVKPRVIQ APSETHIKTT 
DQKGMHISSQ IKKTTDLTTE RLVHVDKRPR TASPHFTVSK ISVPKTEHGY EASIAGSAIA 
TLQKELSATS SAQKITKSVK APTVKPSETR VRAEPTPLPQ FPFADTPDTY KSEAGVEVKK 
EVGVSITGTT VREERFEVLH GREAKVTETA RVPAPVEIPV TPPTLVSGLK NVTVIEGESV 
TLECHISGYP SPTVTWYRED YQIESSIDFQ ITFQSGIARL MIREAFAEDS GRFTCSAVNE 
AGTVSTSCYL AVQVSEEFEK ETTAVTEKFT TEEKRFVESR DVVMTDTSLT EEQAGPGEPA 
APYFITKPVV QKLVEGGSVV FGCQVGGNPK PHVYWKKSGV PLTTGYRYKV SYNKQTGECK 
LVISMTFADD AGEYTIVVRN KHGETSASAS LLEEADYELL MKSQQEMLYQ TQVTAFVQEP 
KVGETAPGFV YSEYEKEYEK EQALIRKKMA KDTVVVRTYV EDQEFHISSF EERLIKEIEY 
RIIKTTLEEL LEEDGEEKMA VDISESEAVE SGFDSRIKNY RILEGMGVTF HCKMSGYPLP 
KIAWYKDGKR IKHGERYQMD FLQDGRASLR IPVVLPEDEG IYTAFASNIK GNAICSGKLY 
VEPAAPLGAP TYIPTLEPVS RIRSLSPRSV SRSPIRMSPA RMSPARMSPA RMSPARMSPG 
RRLEETDESQ LERLYKPVFV LKPVSFKCLE GQTARFDLKV VGRPMPETFW FHDGQQIVND 
YTHKVVIKED GTQSLIIVPA TPSDSGEWTV VAQNRAGRSS ISVILTVEAV EHQVKPMFVE 
KLKNVNIKEG SRLEMKVRAT GNPNPDIVWL KNSDIIVPHK YPKIRIEGTK GEAALKIDST 
VSQDSAWYTA TAINKAGRDT TRCKVNVEVE FAEPEPERKL IIPRGTYRAK EIAAPELEPL 
HLRYGQEQWE EGDLYDKEKQ QKPFFKKKLT SLRLKRFGPA HFECRLTPIG DPTMVVEWLH 
DGKPLEAANR LRMINEFGYC SLDYGVAYSR DSGIITCRAT NKYGTDHTSA TLIVKDEKSL 
VEESQLPEGR KGLQRIEELE RMAHEGALTG VTTDQKEKQK PDIVLYPEPV RVLEGETARF 
RCRVTGYPQP KVNWYLNGQL IRKSKRFRVR YDGIHYLDIV DCKSYDTGEV KVTAENPEGV 
IEHKVKLEIQ QREDFRSVLR RAPEPRPEFH VHEPGKLQFE VQKVDRPVDT TETKEVVKLK 
RAERITHEKV PEESEELRSK FKRRTEEGYY EAITAVELKS RKKDESYEEL LRKTKDELLH 
WTKELTEEEK KALAEEGKIT IPTFKPDKIE LSPSMEAPKI FERIQSQTVG QGSDAHFRVR 
VVGKPDPECE WYKNGVKIER SDRIYWYWPE DNVCELVIRD VTAEDSASIM VKAINIAGET 
SSHAFLLVQA KQLITFTQEL QDVVAKEKDT MATFECETSE PFVKVKWYKD GMEVHEGDKY 
RMHSDRKVHF LSILTIDTSD AEDYSCVLVE DENVKTTAKL IVEGAVVEFV KELQDIEVPE 
SYSGELECIV SPENIEGKWY HNDVELKSNG KYTITSRRGR QNLTVKDVTK EDQGEYSFVI 
DGKKTTCKLK MKPRPIAILQ GLSDQKVCEG DIVQLEVKVS LESVEGVWMK DGQEVQPSDR 
VHIVIDKQSH MLLIEDMTKE DAGNYSFTIP ALGLSTSGRV SVYSVDVITP LKDVNVIEGT 
KAVLECKVSV PDVTSVKWYL NDEQIKPDDR VQAIVKGTKQ RLVINRTHAS DEGPYKLIVG 
RVETNCNLSV EKIKIIRGLR DLTCTETQNV VFEVELSHSG IDVLWNFKDK EIKPSSKYKI 
EAHGKIYKLT VLNMMKDDEG KYTFYAGENM TSGKLTVAGG AISKPLTDQT VAESQEAVFE 
CEVANPDSKG EWLRDGKHLP LTNNIRSESD GHKRRLIIAA TKLDDIGEYT YKVATSKTSA 
KLKVEAVKIK KTLKNLTVTE TQDAVFTVEL THPNVKGVQW IKNGVVLESN EKYAISVKGT 
IYSLRIKNCA IVDESVYGFR LGRLGASARL HVETVKIIKK PKDVTALENA TVAFEVSVSH 
DTVPVKWFHK SVEIKPSDKH RLVSERKVHK LMLQNISPSD AGEYTAVVGQ LECKAKLFVE 
TLHITKTMKN IEVPETKTAS FECEVSHFNV PSMWLKNGVE IEMSEKFKIV VQGKLHQLII 
MNTSTEDSAE YTFVCGNDQV SATLTVTPIM ITSMLKDINA EEKDTITFEV TVNYEGISYK 
WLKNGVEIKS TDKCQMRTKK LTHSLNIRNV HFGDAADYTF VAGKATSTAT LYVEARHIEF 
RKHIKDIKVL EKKRAMFECE VSEPDITVQW MKDDQELQIT DRIKIQKEKY VHRLLIPSTR 
MSDAGKYTVV AGGNVSTAKL FVEGRDVRIR SIKKEVQVIE KQRAVVEFEV NEDDVDAHWY 
KDGIEINFQV QERHKYVVER RIHRMFISET RQSDAGEYTF VAGRNRSSVT LYVNAPEPPQ 
VLQELQPVTV QSGKPARFCA VISGRPQPKI SWYKEEQLLS TGFKCKFLHD GQEYTLLLIE 
AFPEDAAVYT CEAKNDYGVA TTSASLSVEV PEVVSPDQEM PVYPPAIITP LQDTVTSEGQ 
PARFQCRVSG TDLKVSWYSK DKKIKPSRFF RMTQFEDTYQ LEIAEAYPED EGTYTFVASN 
AVGQVSSTAN LSLEGFSKFE ENTSNSQWHV SLSVSFKKEP LGQKPSFIQP LSSLRVHNGE 
TVRFHARVSG IPKPEIQWFH NQQLILPTKD VVFHFEESTG MALMLIVDAY SEHAGQYSCK 
AANSAGEATC AATLTVTPKV QALDRQSSGK DVRESTKSQA VADSSFTKEE SKISQKEIKS 
FQGSSYEYEV QVFESVSQSS IHTAASVQDT QLCHTASLSQ IAESTELSKE CAKESTGEAP 
KIFLHLQDVT VKCGDTAQFL CVLKDDSFID VTWTHEGAKI EESERLKQSQ NGNIQFLTIC 
NVQLVDQGLY SCIVHNDCGE RTTSAVLSVE GAPESILHER IEQEIEMEMK EFSSSFLSAE 
EEGLHSAELQ LSKINETLEL LSESPVYPTK FDSEKEGTGP IFIKEVSNAD ISMGDVATLS 
VTVIGIPKPK IQWFFNGVLL TPSADYKFVF DGDDHSLIIL FTKLEDEGEY TCMASNDYGK 
TICSAYLKIN SKGEGHKDTE TESAVAKSLE KLGGPCPPHF LKELKPIRCA QGLPAIFEYT 
VVGEPAPTVT WFKENKQLCT SVYYTIIHNP NGSGTFIVND PQREDSGLYI CKAENMLGES 
TCAAELLVLL EDTDMTDTPC KAKSTPEAPE DFPQTPLKGP AVEALDSEQE IATFVKDTIL 
KAALITEENQ QLSYEHIAKA NELSSQLPLG AQELQSILEQ DKLTPESTRE FLCINGSIHF 
QPLKEPSPNL QLQIVQSQKT FSKEGILMPE EPETQAVLSD TEKIFPSAMS IEQINSLTVE 
PLKTLLAEPE GNYPQSSIEP PMHSYLTSVA EEVLSPKEKT VSDTNREQRV TLQKQEAQSA 
LILSQSLAEG HVESLQSPDV MISQVNYEPL VPSEHSCTEG GKILIESANP LENAGQDSAV 
RIEEGKSLRF PLALEEKQVL LKEEHSDNVV MPPDQIIESK REPVAIKKVQ EVQGRDLLSK 
ESLLSGIPEE QRLNLKIQIC RALQAAVASE QPGLFSEWLR NIEKVEVEAV NITQEPRHIM 
CMYLVTSAKS VTEEVTIIIE DVDPQMANLK MELRDALCAI IYEEIDILTA EGPRIQQGAK 
TSLQEEMDSF SGSQKVEPIT EPEVESKYLI STEEVSYFNV QSRVKYLDAT PVTKGVASAV 
VSDEKQDESL KPSEEKEESS SESGTEEVAT VKIQEAEGGL IKEDGPMIHT PLVDTVSEEG 
DIVHLTTSIT NAKEVNWYFE NKLVPSDEKF KCLQDQNTYT LVIDKVNTED HQGEYVCEAL 
NDSGKTATSA KLTVVKRAAP VIKRKIEPLE VALGHLAKFT CEIQSAPNVR FQWFKAGREI 
YESDKCSIRS SKYISSLEIL RTQVVDCGEY TCKASNEYGS VSCTATLTVT EAYPPTFLSR 
PKSLTTFVGK AAKFICTVTG TPVIETIWQK DGAALSPSPN WRISDAENKH ILELSNLTIQ 
DRGVYSCKAS NKFGADICQA ELIIIDKPHF IKELEPVQSA INKKVHLECQ VDEDRKVTVT 
WSKDGQKLPP GKDYKICFED KIATLEIPLA KLKDSGTYVC TASNEAGSSS CSATVTVREP 
PSFVKKVDPS YLMLPGESAR LHCKLKGSPV IQVTWFKNNK ELSESNTVRM YFVNSEAILD 
ITDVKVEDSG SYSCEAVNDV GSDSCSTEIV IKEPPSFIKT LEPADIVRGT NALLQCEVSG 
TGPFEISWFK DKKQIRSSKK YRLFSQKSLV CLEIFSFNSA DVGEYECVVA NEVGKCGCMA 
THLLKEPPTF VKKVDDLIAL GGQTVTLQAA VRGSEPISVT WMKGQEVIRE DGKIKMSFSN 
GVAVLIIPDV QISFGGKYTC LAENEAGSQT SVGELIVKEP AKIIERAELI QVTAGDPATL 
EYTVAGTPEL KPKWYKDGRP LVASKKYRIS FKNNVAQLKF YSAELHDSGQ YTFEISNEVG 
SSSCETTFTV LDRDIAPFFT KPLRNVDSVV NGTCRLDCKI AGSLPMRVSW FKDGKEIAAS 
DRYRIAFVEG TASLEIIRVD MNDAGNFTCR ATNSVGSKDS SGALIVQEPP SFVTKPGSKD 
VLPGSAVCLK STFQGSTPLT IRWFKGNKEL VSGGSCYITK EALESSLELY LVKTSDSGTY 
TCKVSNVAGG VECSANLFVK EPATFVEKLE PSQLLKKGDA TQLACKVTGT PPIKITWFAN 
DREIKESSKH RMSFVESTAV LRLTDVGIED SGEYMCEAQN EAGSDHCSSI VIVKESPYFT 
KEFKPIEVLK EYDVMLLAEV AGTPPFEITW FKDNTILRSG RKYKTFIQDH LVSLQILKFV 
AADAGEYQCR VTNEVGSSIC SARVTLREPP SFIKKIESTS SLRGGTAAFQ ATLKGSLPIT 
VTWLKDSDEI TEDDNIRMTF ENNVASLYLS GIEVKHDGKY VCQAKNDAGI QRCSALLSVK 
EPATITEEAV SIDVTQGDPA TLQVKFSGTK EITAKWFKDG QELTLGSKYK ISVTDTVSIL 
KIISTEKKDS GEYTFEVQND VGRSSCKARI NVLDLIIPPS FTKKLKKMDS IKGSFIDLEC 
IVAGSHPISI QWFKDDQEIS ASEKYKFSFH DNTAFLEISQ LEGTDSGTYT CSATNKAGHN 
QCSGHLTVKE PPYFVEKPQS QDVNPNTRVQ LKALVGGTAP MTIKWFKDNK ELHSGAARSV 
WKDDTSTSLE LFAAKATDSG TYICQLSNDV GTATSKATLF VKEPPQFIKK PSPVLVLRNG 
QSTTFECQIT GTPKIRVSWY LDGNEITAIQ KHGISFIDGL ATFQISGARV ENSGTYVCEA 
RNDAGTASCS IELKVKEPPT FIRELKPVEV VKYSDVELEC EVTGTPPFEV TWLKNNREIR 
SSKKYTLTDR VSVFNLHITK CDPSDTGEYQ CIVSNEGGSC SCSTRVALKE PPSFIKKIEN 
TTTVLKSSAT FQSTVAGSPP ISITWLKDDQ ILDEDDNVYI SFVDSVATLQ IRSVDNGHSG 
RYTCQAKNES GVERCYAFLL VQEPAQIVEK AKSVDVTEKD PMTLECVVAG TPELKVKWLK 
DGKQIVPSRY FSMSFENNVA SFRIQSVMKQ DSGQYTFKVE NDFGSSSCDA YLRVLDQNIP 
PSFTKKLTKM DKVLGSSIHM ECKVSGSLPI SAQWFKDGKE ISTSAKYRLV CHERSVSLEV 
NNLELEDTAN YTCKVSNVAG DDACSGILTV KEPPSFLVKP GRQQAIPDST VEFKAILKGT 
PPFKIKWFKD DVELVSGPKC FIGLEGSTSF LNLYSVDASK TGQYTCHVTN DVGSDSCTTM 
LLVTEPPKFV KKLEASKIVK AGDSSRLECK IAGSPEIRVV WFRNEHELPA SDKYRMTFID 
SVAVIQMNNL STEDSGDFIC EAQNPAGSTS CSTKVIVKEP PVFSSFPPIV ETLKNAEVSL 
ECELSGTPPF EVVWYKDKRQ LRSSKKYKIA SKNFHTSIHI LNVDTSDIGE YHCKAQNEVG 
SDTCVCTVKL KEPPRFVSKL NSLTVVAGEP AELQASIEGA QPIFVQWLKE KEEVIRESEN 
IRITFVENVA TLQFAKAEPA NAGKYICQIK NDGGMRENMA TLMVLEPAVI VEKAGPMTVT 
VGETCTLECK VAGTPELSVE WYKDGKLLTS SQKHKFSFYN KISSLRILSV ERQDAGTYTF 
QVQNNVGKSS CTAVVDVSDR AVPPSFTRRL KNTGGVLGAS CILECKVAGS SPISVAWFHE 
KTKIVSGAKY QTTFSDNVCT LQLNSLDSSD MGNYTCVAAN VAGSDECRAV LTVQEPPSFV 
KEPEPLEVLP GKNVTFTSVI RGTPPFKVNW FRGARELVKG DRCNIYFEDT VAELELFNID 
ISQSGEYTCV VSNNAGQASC TTRLFVKEPA AFLKRLSDHS VEPGKSIILE STYTGTLPIS 
VTWKKDGFNI TTSEKCNIVT TEKTCILEIL NSTKRDAGQY SCEIENEAGR DVCGALVSTL 
EPPYFVTELE PLEAAVGDSV SLQCQVAGTP EITVSWYKGD TKLRPTPEYR TYFTNNVATL 
VFNKVNINDS GEYTCKAENS IGTASSKTVF RIQERQLPPS FARQLKDIEQ TVGLPVTLTC 
RLNGSAPIQV CWYRDGVLLR DDENLQTSFV DNVATLKILQ TDLSHSGQYS CSASNPLGTA 
SSSARLTARE PKKSPFFDIK PVSIDVIAGE SADFECHVTG AQPMRITWSK DNKEIRPGGN 
YTITCVGNTP HLRILKVGKG DSGQYTCQAT NDVGKDMCSA QLSVKEPPKF VKKLEASKVA 
KQGESIQLEC KISGSPEIKV SWFRNDSELH ESWKYNMSFI NSVALLTINE ASAEDSGDYI 
CEAHNGVGDA SCSTALTVKA PPVFTQKPSP VGALKGSDVI LQCEISGTPP FEVVWVKDRK 
QVRNSKKFKI TSKHFDTSLH ILNLEASDVG EYHCKATNEV GSDTCSCSVK FKEPPRFVKK 
LSDTSTLIGD AVELRAIVEG FQPISVVWLK DRGEVIRESE NTRISFIDNI ATLQLGSPEA 
SNSGKYICQI KNDAGMRECS AVLTVLEPAR IIEKPEPMTV TTGNPFALEC VVTGTPELSA 
KWFKDGRELS ADSKHHITFI NKVASLKIPC AEMSDKGLYS FEVKNSVGKS NCTVSVHVSD 
RIVPPSFIRK LKDVNAILGA SVVLECRVSG SAPISVGWFQ DGNEIVSGPK CQSSFSENVC 
TLNLSLLEPS DTGIYTCVAA NVAGSDECSA VLTVQEPPSF EQTPDSVEVL PGMSLTFTSV 
IRGTPPFKVK WFKGSRELVP GESCNISLED FVTELELFEV QPLESGDYSC LVTNDAGSAS 
CTTHLFVKEP ATFVKRLADF SVETGSPIVL EATYTGTPPI SVSWIKDEYL ISQSERCSIT 
MTEKSTILEI LESTIEDYAQ YSCLIENEAG QDICEALVSV LEPPYFIEPL EHVEAVIGEP 
ATLQCKVDGT PEIRISWYKE HTKLRSAPAY KMQFKNNVAS LVINKVDHSD VGEYSCKADN 
SVGAVASSAV LVIKARKLPP FFARKLKDVH ETLGFPVAFE CRINGSEPLQ VSWYKDGVLL 
KDDANLQTSF VHNVATLQIL QTDQSHIGQY NCSASNPLGT ASSSAKLILS EHEVPPFFDL 
KPVSVDLALG ESGTFKCHVT GTAPIKITWA KDNREIRPGG NYKMTLVENT ATLTVLKVGK 
GDAGQYTCYA SNIAGKDSCS AQLGVQEPPR FIKKLEPSRI VKQDEFTRYE CKIGGSPEIK 
VLWYKDETEI QESSKFRMSF VDSVAVLEMH NLSVEDSGDY TCEAHNAAGS ASSSTSLKVK 
EPPIFRKKPH PIETLKGADV HLECELQGTP PFHVSWYKDK RELRSGKKYK IMSENFLTSI 
HILNVDAADI GEYQCKATND VGSDTCVGSI ALKAPPRFVK KLSDISTVVG KEVQLQTTIE 
GAEPISVVWF KDKGEIVRES DNIWISYSEN IATLQFSRVE PANAGKYTCQ IKNDAGMQEC 
FATLSVLEPA TIVEKPESIK VTTGDTCTLE CTVAGTPELS TKWFKDGKEL TSDNKYKISF 
FNKVSGLKII NVAPSDSGVY SFEVQNPVGK DSCTASLQVS DRTVPPSFTR KLKETNGLSG 
SSVVMECKVY GSPPISVSWF HEGNEISSGR KYQTTLTDNT CALTVNMLEE SDSGDYTCIA 
TNMAGSDECS APLTVREPPS FVQKPDPMDV LTGTNVTFTS IVKGTPPFSV SWFKGSSELV 
PGDRCNVSLE DSVAELELFD VDTSQSGEYT CIVSNEAGKA SCTTHLYIKA PAKFVKRLND 
YSIEKGKPLI LEGTFTGTPP ISVTWKKNGI NVTPSQRCNI TTTEKSAILE IPSSTVEDAG 
QYNCYIENAS GKDSCSAQIL ILEPPYFVKQ LEPVKVSVGD SASLQCQLAG TPEIGVSWYK 
GDTKLRPTTT YKMHFRNNVA TLVFNQVDIN DSGEYICKAE NSVGEVSAST FLTVQEQKLP 
PSFSRQLRDV QETVGLPVVF DCAISGSEPI SVSWYKDGKP LKDSPNVQTS FLDNTATLNI 
FKTDRSLAGQ YSCTATNPIG SASSSARLIL TEGKNPPFFD IRLAPVDAVV GESADFECHV 
TGTQPIKVSW AKDSREIRSG GKYQISYLEN SAHLTVLKVD KGDSGQYTCY AVNEVGKDSC 
TAQLNIKERL IPPSFTKRLS ETVEETEGNS FKLEGRVAGS QPITVAWYKN NIEIQPTSNC 
EITFKNNTLV LQVRKAGMND AGLYTCKVSN DAGSALCTSS IVIKEPKKPP VFDQHLTPVT 
VSEGEYVQLS CHVQGSEPIR IQWLKAGREI KPSDRCSFSF ASGTAVLELR DVAKADSGDY 
VCKASNVAGS DTTKSKVTIK DKPAVAPATK KAAVDGRLFF VSEPQSIRVV EKTTATFIAK 
VGGDPIPNVK WTKGKWRQLN QGGRVFIHQK GDEAKLEIRD TTKTDSGLYR CVAFNEHGEI 
ESNVNLQVDE RKKQEKIEGD LRAMLKKTPI LKKGAGEEEE IDIMELLKNV DPKEYEKYAR 
MYGITDFRGL LQAFELLKQS QEEETHRLEI EEIERSERDE KEFEELVSFI QQRLSQTEPV 
TLIKDIENQT VLKDNDAVFE IDIKINYPEI KLSWYKGTEK LEPSDKFEIS IDGDRHTLRV 
KNCQLKDQGN YRLVCGPHIA SAKLTVIEPA WERHLQDVTL KEGQTCTMTC QFSVPNVKSE 
WFRNGRILKP QGRHKTEVEH KVHKLTIADV RAEDQGQYTC KYEDLETSAE LRIEAEPIQF 
TKRIQNIVVS EHQSATFECE VSFDDAIVTW YKGPTELTES QKYNFRNDGR CHYMTIHNVT 
PDDEGVYSVI ARLEPRGEAR STAELYLTTK EIKLELKPPD IPDSRVPIPT MPIRAVPPEE 
IPPVVAPPIP LLLPTPEEKK PPPKRIEVTK KAVKKDAKKV VAKPKEMTPR EEIVKKPPPP 
TTLIPAKAPE IIDVSSKAEE VKIMTITRKK EVQKEKEAVY EKKQAVHKEK RVFIESFEEP 
YDELEVEPYT EPFEQPYYEE PDEDYEEIKV EAKKEVHEEW EEDFEEGQEY YEREEGYDEG 
EEEWEEAYQE REVIQVQKEV YEESHERKVP AKVPEKKAPP PPKVIKKPVI EKIEKTSRRM 
EEEKVQVTKV PEVSKKIVPQ KPSRTPVQEE VIEVKVPAVH TKKMVISEEK MFFASHTEEE 
VSVTVPEVQK EIVTEEKIHV AISKRVEPPP KVPELPEKPA PEEVAPVPIP KKVEPPAPKV 
PEVPKKPVPE EKKPVPVPKK EPAAPPKVPE VPKKPVPEEK IPVPVAKKKE APPAKVPEVQ 
KGVVTEEKIT IVTQREESPP PAVPEIPKKK VPEERKPVPR KEEEVPPPPK VPALPKKPVP 
EEKVAVPVPV AKKAPPPRAE VSKKTVVEEK RFVAEEKLSF AVPQRVEVTR HEVSAEEEWS 
YSEEEEGVSI SVYREEEREE EEEAEVTEYE VMEEPEEYVV EEKLHIISKR VEAEPAEVTE 
RQEKKIVLKP KIPAKIEEPP PAKVPEAPKK IVPEKKVPAP VPKKEKVPPP KVPEEPKKPV 
PEKKVPPKVI KMEEPLPAKV TERHMQITQE EKVLVAVTKK EAPPKARVPE EPKRAVPEEK 
VLKLKPKREE EPPAKVTEFR KRVVKEEKVS IEAPKREPQP IKEVTIMEEK ERAYTLEEEA 
VSVQREEEYE EYEEYDYKEF EEYEPTEEYD QYEEYEEREY ERYEEHEEYI TEPEKPIPVK 
PVPEEPVPTK PKAPPAKVLK KAVPEEKVPV PIPKKLKPPP PKVPEEPKKV FEEKIRISIT 
KREKEQVTEP AAKVPMKPKR VVAEEKVPVP RKEVAPPVRV PEVPKELEPE EVAFEEEVVT 
HVEEYLVEEE EEYIHEEEEF ITEEEVVPVI PVKVPEVPRK PVPEEKKPVP VPKKKEAPPA 
KVPEVPKKPE EKVPVLIPKK EKPPPAKVPE VPKKPVPEEK VPVPVPKKVE APPAKVPEVP 
KKPVPEKKVP VPAPKKVEAP PAKVPEVPKK LIPEEKKPTP VPKKVEAPPP KVPKKREPVP 
VPVALPQEEE VLFEEEIVPE EEVLPEEEEV LPEEEEVLPE EEEVLPEEEE IPPEEEEVPP 
EEEYVPEEEE FVPEEEVLPE VKPKVPVPAP VPEVPKKPVP EKKVPVPAPK KVEPPPPPKV 
PEIKKKVTEK KVVIPKKEEA PPAKVSVVPK KPEPEKKVPP PGLKKAVAPP AKVPEVPKKV 
EEKRIILPKE EEVLPVEVTE EPEEEPISEE EIPEEPPSIE EVEEVAPPRV PEVIKKAVPE 
APTPVPKKVE APPAKVSKKI PEEKVPVPVQ KKEAPPAKVP EVPKKVPEKK VLVPKKEAVP 
PAKGRTVLEE KVSVAFRQEV VVKERLELEV VEAEVEEIPE EEEFHEVEEY FEEGEFHEVE 
EFIKLEQHRV EEEHRVEKVH RVIEVFEAEE VEVFEKPKAP PKGPEISEKI IPPKKPPTKV 
VPRKEPPAKV PEVPKKIVVE EKVRVPEEPR VPPTKAPEVP KKIVPEEKVR EAVLKKPEVP 
PAKVPGMPKK SVQEEKSPIV ISEDTEMYIY EASEEAVLEE KVLVTQPQKT KPKLAKVPEP 
PKKVVPEDKI YVTIPKKRET PATKEPDTTR GIFPEVEPPE AIPEIPEHPP TEEFEVFKEV 
IPEGETPIVK RRKTPSPTVP ESPREIVPVK ETPMAAPLEI EIPPTKAPEA MKEVVPEMKI 
FEDVPEEPET PRMKTPEAPQ EIIPAKTVPS KKREPPSVKV PEALQEIVPE KKTLVVPLRK 
PEVLPDEVPE ALREVVPEKK VHPPQRAEVV PVKVHEAPKE IIPEKKVSVV PPKKPEVPPV 
KVPEASKEVI REEKVPLAPP KEPEVPPVKV PEPPKEVVPE KKAPVAPPKE PEVPPVKVPE 
APKEVVPEKK VPVPPPKKPE VPPTKVPEVP KAAVPEKKLP EAIPPKPESP PPEVPEVLPP 
KEVVPEKKVP VPPAKKPEAP PPKVPEAPKE VVLEKKASVA VPKKPEAPRA KVPEAAQEVV 
PEKKIPKAPI KKPEAPAVTV PEVPQEATEK EIPVAPPKKP EAPIVPVPEA QEVVPEKKVP 
KAPPTKPEAP PATVPEVPQE IVPEKKTLVL PKKPEVPPVT VPEAPKEVVL EKKVPSAPPK 
KPEVPPVKVP EAPKEVVPEK KVPVPPPKKP EVPPTKVPEV PKAAVPEKKV PEAIPPKPES 
PPPEVPEVLP PKEVVPEKKV PVPPAKKPEA PPPKVPEAPK EVVLEKKASV AVPKKPEAPR 
AKVPEAAQEV VPEKKIPKAP IKKPEAPAVT VPEVPQEAAE KEIPVAPPKK PEAPIVPVPE 
AQEVVPEKKV PKAPPTKPEA PPATVPEVPQ EIVPEKKTLV LPKKPEVPPV TVPEAPKEVV 
LEKKVPSTPP KKPEVPPVKV PEAPKEVVPE KKVPVPPPKK PEVPPTKVPE VPKAAVPEKK 
VPEAIPPKPE SPPPEVPEVL PPKEVVPEKK VPVPPAKKPE APPPKVPEAP KEVVLEKKVS 
VAVPKKPEAP RAKVPEAAQE VVPEKKIPKA PIKKPEAPAV TVPEVPQEAA EKEIPVAPPK 
KPEAPIVPVP EAQEVVPEKK VPKAPPTKPE APPATVPEVP QEIVPEKKTL VLPKKPEVPP 
VTVPEAPKEV VLEKKVPLAP PKKPEVPPVK VPEAPKEVVP EKKVPVTPPK KPEVPPVKVP 
EAPIEVVPEK KMPLAPPKKP EVPPVKVPEA PKEVVPEKKV PSAPPKKPEV PPVKVPEAPK 
EVVPEKKVPA APPKKPEVTP VKVPEAPKEV VPEKKVPVPP PKKPEVPPTK VPEVPKVAVP 
EKKVPEAIPP KPESPPPEVF EEPEEVALEE PPAEVVEEPE PAAPPQVTVP PKKPVPEKKA 
PAVVAKKPEL PPVKVPEVPK EVVPEKKVPL VVPKKPEAPP AKVPEVPKEV VPEKKVAVPK 
KPEVPPAKVP EVPKKPVLEE KPAVPVPERA ESPPPEVYEE PEEIAPEEEI APEEEKPVPV 
AEEEEPEVPP PAVPEEPKKI IPEKKVPVIK KPEAPPPKEP EMPKKVVPVK KVPTVKKPET 
PAAKVPEVPK KLVPVKKEPV PVTKKPEVLP EKVPKVPEKI IPEKEVSVPI PAEPEVPPAE 
VEETPEEIIY EEKASITIGR KETPPVEERE IEKYIKPEEP EPEPQPEEIP VKEPEPEKVI 
EKPKLKPRPP PPPPAPPKED VKEKIFQLKA IPKKKVPEKP QVPEKVELTP LKVPGGEKKV 
RKLLPERKPE PKEEVVLKSV LRKRPEEEEP KVEPKKLEKV KKPAVPEPPP PKPVEEVEVP 
TVTKRERKIP EPTKVPEIKP AIPLPAPEPK PKPEAEVKTI KPPPVEPEPT PIAAPVTVPV 
VGKKAEAKAP KEEAAKPKGP IKGVPKKTPS PIEAERRKLR PGSGGEKPPD EAPFTYQLKA 
VPLKFVKEIK DIILTESEFV GSSAIFECLV SPSTAITTWM KDGSNIRESP KHRFIADGKD 
RKLHIIDVQL SDAGEYTCVL RLGNKEKTST AKLVVEELPV RFVKTLEEEV TVVKGQPLYL 
SCELNKERDV VWRKDGKIVV EKPGRIVPGV IGLMRALTIN DADDTDAGTY TVTVENANNL 
ECSSCVKVVE VIRDWLVKPI RDQHVKPKGT AIFACDIAKD TPNIKWFKGY DEIPAEPNDK 
TEILRDGNHL YLKIKNAMPE DIAEYAVEIE GKRYPAKLTL GEREVELLKP IEDVTIYEKE 
SASFDAEISE ADIPGQWKLK GELLRPSPTC EIKAEGGKRF LTLHKVKLDQ AGEVLYQALN 
AITTAILTVK EIELDFAVPL KDVTVPERRQ ARFECVLTRE ANVIWSKGPD IIKSSDKFDI 
IADGKKHILV INDSQFDDEG VYTAEVEGKK TSARLFVTGI RLKFMSPLED QTVKEGETAT 
FVCELSHEKM HVVWFKNDAK LHTSRTVLIS SEGKTHKLEM KEVTLDDISQ IKAQVKELSS 
TAQLKVLEAD PYFTVKLHDK TAVEKDEITL KCEVSKDVPV KWFKDGEEIV PSPKYSIKAD 
GLRRILKIKK ADLKDKGEYV CDCGTDKTKA NVTVEARLIK VEKPLYGVEV FVGETAHFEI 
ELSEPDVHGQ WKLKGQPLTA SPDCEIIEDG KKHILILHNC QLGMTGEVSF QAANAKSAAN 
LKVKELPLIF ITPLSDVKVF EKDEAKFECE VSREPKTFRW LKGTQEITGD DRFELIKDGT 
KHSMVIKSAA FEDEAKYMFE AEDKHTSGKL IIEGIRLKFL TPLKDVTAKE KESAVFTVEL 
SHDNIRVKWF KNDQRLHTTR SVSMQDEGKT HSITFKDLSI DDTSQIRVEA MGMSSEAKLT 
VLEGDPYFTG KLQDYTGVEK DEVILQCEIS KADAPVKWFK DGKEIKPSKN AVIKADGKKR 
MLILKKALKS DIGQYTCDCG TDKTSGKLDI EDREIKLVRP LHSVEVMETE TARFETEISE 
DDIHANWKLK GEALLQTPDC EIKEEGKIHS LVLHNCRLDQ TGGVDFQAAN VKSSAHLRVK 
PRVIGLLRPL KDVTVTAGET ATFDCELSYE DIPVEWYLKG KKLEPSDKVV PRSEGKVHTL 
TLRDVKLEDA GEVQLTAKDF KTHANLFVKE PPVEFTKPLE DQTVEEGATA VLECEVSREN 
AKVKWFKNGT EILKSKKYEI VADGRVRKLV IHDCTPEDIK TYTCDAKDFK TSCNLNVVPP 
HVEFLRPLTD LQVREKEMAR FECELSRENA KVKWFKDGAE IKKGKKYDII SKGAVRILVI 
NKCLLDDEAE YSCEVRTART SGMLTVLEEE AVFTKNLANI EVSETDTIKL VCEVSKPGAE 
VIWYKGDEEI IETGRYEILT EGRKRILVIQ NAHLEDAGNY NCRLPSSRTD GKVKVHELAA 
EFISKPQNLE ILEGEKAEFV CSISKESFPV QWKRDDKTLE SGDKYDVIAD GKKRVLVVKD 
ATLQDMGTYV VMVGAARAAA HLTVIEKLRI VVPLKDTRVK EQQEVVFNCE VNTEGAKAKW 
FRNEEAIFDS SKYIILQKDL VYTLRIRDAH LDDQANYNVS LTNHRGENVK SAANLIVEEE 
DLRIVEPLKD IETMEKKSVT FWCKVNRLNV TLKWTKNGEE VPFDNRVSYR VDKYKHMLTI 
KDCGFPDEGE YIVTAGQDKS VAELLIIEAP TEFVEHLEDQ TVTEFDDAVF SCQLSREKAN 
VKWYRNGREI KEGKKYKFEK DGSIHRLIIK DCRLDDECEY ACGVEDRKSR ARLFVEEIPV 
EIIRPPQDIL EAPGADVVFL AELNKDKVEV QWLRNNMVVV QGDKHQMMSE GKIHRLQICD 
IKPRDQGEYR FIAKDKEARA KLELAAAPKI KTADQDLVVD VGKPLTMVVP YDAYPKAEAE 
WFKENEPLST KTIDTTAEQT SFRILEAKKG DKGRYKIVLQ NKHGKAEGFI NLKVIDVPGP 
VRNLEVTETF DGEVSLAWEE PLTDGGSKII GYVVERRDIK RKTWVLATDR AESCEFTVTG 
LQKGGVEYLF RVSARNRVGT GEPVETDNPV EARSKYDVPG PPLNVTITDV NRFGVSLTWE 
PPEYDGGAEI TNYVIELRDK TSIRWDTAMT VRAEDLSATV TDVVEGQEYS FRVRAQNRIG 
VGKPSAATPF VKVADPIERP SPPVNLTSSD QTQSSVQLKW EPPLKDGGSP ILGYIIERCE 
EGKDNWIRCN MKLVPELTYK VTGLEKGNKY LYRVSAENKA GVSDPSEILG PLTADDAFVE 
PTMDLSAFKD GLEVIVPNPI TILVPSTGYP RPTATWCFGD KVLETGDRVK MKTLSAYAEL 
VISPSERSDK GIYTLKLENR VKTISGEIDV NVIARPSAPK ELKFGDITKD SVHLTWEPPD 
DDGGSPLTGY VVEKREVSRK TWTKVMDFVT DLEFTVPDLV QGKEYLFKVC ARNKCGPGEP 
AYVDEPVNMS TPATVPDPPE NVKWRDRTAN SIFLTWDPPK NDGGSRIKGY IVERCPRGSD 
KWVACGEPVA ETKMEVTGLE EGKWYAYRVK ALNRQGASKP SRPTEEIQAV DTQEAPEIFL 
DVKLLAGLTV KAGTKIELPA TVTGKPEPKI TWTKADMILK QDKRITIENV PKKSTVTIVD 
SKRSDTGTYI IEAVNVCGRA TAVVEVNVLD KPGPPAAFDI TDVTNESCLL TWNPPRDDGG 
SKITNYVVER RATDSEVWHK LSSTVKDTNF KATKLIPNKE YIFRVAAENM YGVGEPVQAS 
PITAKYQFDP PGPPTRLEPS DITKDAVTLT WCEPDDDGGS PITGYWVERL DPDTDKWVRC 
NKMPVKDTTY RVKGLTNKKK YRFRVLAENL AGPGKPSKST EPILIKDPID PPWPPGKPTV 
KDVGKTSVRL NWTKPEHDGG AKIESYVIEM LKTGTDEWVR VAEGVPTTQH LLPGLMEGQE 
YSFRVRAVNK AGESEPSEPS DPVLCREKLY PPSPPRWLEV INITKNTADL KWTVPEKDGG 
SPITNYIVEK RDVRRKGWQT VDTTVKDTKC TVTPLTEGSL YVFRVAAENA IGQSDYTEIE 
DSVLAKDTFT TPGPPYALAV VDVTKRHVDL KWEPPKNDGG RPIQRYVIEK KERLGTRWVK 
AGKTAGPDCN FRVTDVIEGT EVQFQVRAEN EAGVGHPSEP TEILSIEDPT SPPSPPLDLH 
VTDAGRKHIA IAWKPPEKNG GSPIIGYHVE MCPVGTEKWM RVNSRPIKDL KFKVEEGVVP 
DKEYVLRVRA VNAIGVSEPS EISENVVAKD PDCKPTIDLE THDIIVIEGE KLSIPVPFRA 
VPVPTVSWHK DGKEVKASDR LTMKNDHISA HLEVPKSVRA DAGIYTITLE NKLGSATASI 
NVKVIGLPGP CKDIKASDIT KSSCKLTWEP PEFDGGTPIL HYVLERREAG RRTYIPVMSG 
ENKLSWTVKD LIPNGEYFFR VKAVNKVGGG EYIELKNPVI AQDPKQPPDP PVDVEVHNPT 
AEAMTITWKP PLYDGGSKIM GYIIEKIAKG EERWKRCNEH LVPILTYTAK GLEEGKEYQF 
RVRAENAAGI SEPSRATPPT KAVDPIDAPK VILRTSLEVK RGDEIALDAS ISGSPYPTIT 
WIKDENVIVP EEIKKRAAPL VRRRKGEVQE EEPFVLPLTQ RLSIDNSKKG ESQLRVRDSL 
RPDHGLYMIK VENDHGIAKA PCTVSVLDTP GPPINFVFED IRKTSVLCKW EPPLDDGGSE 
IINYTLEKKD KTKPDSEWIV VTSTLRHCKY SVTKLIEGKE YLFRVRAENR FGPGPPCVSK 
PLVAKDPFGP PDAPDKPIVE DVTSNSMLVK WNEPKDNGSP ILGYWLEKRE VNSTHWSRVN 
KSLLNALKAN VDGLLEGLTY VFRVCAENAA GPGKFSPPSD PKTAHDPISP PGPPIPRVTD 
TSSTTIELEW EPPAFNGGGE IVGYFVDKQL VGTNEWSRCT EKMIKVRQYT VKEIREGADY 
KLRVSAVNAA GEGPPGETQP VTVAEPQEPP AVELDVSVKG GIQIMAGKTL RIPAVVTGRP 
VPTKVWTKEE GELDKDRVVI DNVGTKSELI IKDALRKDHG RYVITATNSC GSKFAAARVE 
VFDVPGPVLD LKPVVTNRKM CLLNWSDPED DGGSEITGFI IERKDAKMHT WRQPIETERS 
KCDITGLLEG QEYKFRVIAK NKFGCGPPVE IGPILAVDPL GPPTSPERLT YTERTKSTIT 
LDWKEPRSNG GSPIQGYIIE KRRHDKPDFE RVNKRLCPTT SFLVENLDEH QMYEFRVKAV 
NEIGESEPSL PLNVVIQDDE VPPTIKLRLS VRGDTIKVKA GEPVHIPADV TGLPMPKIEW 
SKNETVIEKP TDALQITKEE VSRSEAKTEL SIPKAVREDK GTYTVTASNR LGSVFRNVHV 
EVYDRPSPPR NLAVTDIKAE SCYLTWDAPL DNGGSEITHY VIDKRDASRK KAEWEEVTNT 
AVEKRYGIWK LIPNGQYEFR VRAVNKYGIS DECKSDKVVI QDPYRLPGPP GKPKVLARTK 
GSMLVSWTPP LDNGGSPITG YWLEKREEGS PYWSRVSRAP ITKVGLKGVE FNVPRLLEGV 
KYQFRAMAIN AAGIGPPSEP SDPEVAGDPI FPPGPPSCPE VKDKTKSSIS LGWKPPAKDG 
GSPIKGYIVE MQEEGTTDWK RVNEPDKLIT TCECVVPNLK ELRKYRFRVK AVNEAGESEP 
SDTTGEIPAT DIQEEPEVFI DIGAQDCLVC KAGSQIRIPA VIKGRPTPKS SWEFDGKAKK 
AMKDGVHDIP EDAQLETAEN SSVIIIPECK RSHTGKYSIT AKNKAGQKTA NCRVKVMDVP 
GPPKDLKVSD ITRGSCRLSW KMPDDDGGDR IKGYVIEKRT IDGKAWTKVN PDCGSTTFVV 
PDLLSEQQYF FRVRAENRFG IGPPVETIQR TTARDPIYPP DPPIKLKIGL ITKNTVHLSW 
KPPKNDGGSP VTHYIVECLA WDPTGTKKEA WRQCNKRDVE ELQFTVEDLV EGGEYEFRVK 
AVNAAGVSKP SATVGPVTVK DQTCPPSIDL KEFMEVEEGT NVNIVAKIKG VPFPTLTWFK 
APPKKPDNKE PVLYDTHVNK LVVDDTCTLV IPQSRRSDTG LYTITAVNNL GTASKEMRLN 
VLGRPGPPVG PIKFESVSAD QMTLSWFPPK DDGGSKITNY VIEKREANRK TWVHVSSEPK 
ECTYTIPKLL EGHEYVFRIM AQNKYGIGEP LDSEPETARN LFSVPGAPDK PTVSSVTRNS 
MTVNWEEPEY DGGSPVTGYW LEMKDTTSKR WKRVNRDPIK AMTLGVSYKV TGLIEGSDYQ 
FRVYAINAAG VGPASLPSDP ATARDPIAPP GPPFPKVTDW TKSSADLEWS PPLKDGGSKV 
TGYIVEYKEE GKEEWEKGKD KEVRGTKLVV TGLKEGAFYK FRVRAVNIAG IGEPGEVTDV 
IEMKDRLVSP DLQLDASVRD RIVVHAGGVI RIIAYVSGKP PPTVTWNMNE RTLPQEATIE 
TTAISSSMVI KNCQRSHQGV YSLLAKNEAG ERKKTIIVDV LDVPGPVGTP FLAHNLTNES 
CKLTWFSPED DGGSPITNYV IEKRESDRRA WTPVTYTVTR QNATVQGLIQ GKAYFFRIAA 
ENSIGMGPFV ETSEALVIRE PITVPERPED LEVKEVTKNT VTLTWNPPKY DGGSEIINYV 
LESRLIGTEK FHKVTNDNLL SRKYTVKGLK EGDTYEYRVS AVNIVGQGKP SFCTKPITCK 
DELAPPTLHL DFRDKLTIRV GEAFALTGRY SGKPKPKVSW FKDEADVLED DRTHIKTTPA 
TLALEKIKAK RSDSGKYCVV VENSTGSRKG FCQVNVVDRP GPPVGPVSFD EVTKDYMVIS 
WKPPLDDGGS KITNYIIEKK EVGKDVWMPV TSASAKTTCK VSKLLEGKDY IFRIHAENLY 
GISDPLVSDS MKAKDRFRVP DAPDQPIVTE VTKDSALVTW NKPHDGGKPI TNYILEKRET 
MSKRWARVTK DPIHPYTKFR VPDLLEGCQY EFRVSAENEI GIGDPSPPSK PVFAKDPIAK 
PSPPVNPEAI DTTCNSVDLT WQPPRHDGGS KILGYIVEYQ KVGDEEWRRA NHTPESCPET 
KYKVTGLRDG QTYKFRVLAV NAAGESDPAH VPEPVLVKDR LEPPELILDA NMAREQHIKV 
GDTLRLSAII KGVPFPKVTW KKEDRDAPTK ARIDVTPVGS KLEIRNAAHE DGGIYSLTVE 
NPAGSKTVSV KVLVLDKPGP PRDLEVSEIR KDSCYLTWKE PLDDGGSVIT NYVVERRDVA 
SAQWSPLSAT SKKKSHFAKH LNEGNQYLFR VAAENQYGRG PFVETPKPIK ALDPLHPPGP 
PKDLHHVDVD KTEVSLVWNK PDRDGGSPIT GYLVEYQEEG TQDWIKFKTV TNLECVVTGL 
QQGKTYRFRV KAENIVGLGL PDTTIPIECQ EKLVPPSVEL DVKLIEGLVV KAGTTVRFPA 
IIRGVPVPTA KWTTDGSEIK TDEHYTVETD NFSSVLTIKN CLRRDTGEYQ ITVSNAAGSK 
TVAVHLTVLD VPGPPTGPIN ILDVTPEHMT ISWQPPKDDG GSPVINYIVE KQDTRKDTWG 
VVSSGSSKTK LKIPHLQKGC EYVFRVRAEN KIGVGPPLDS TPTVAKHKFS PPSPPGKPVV 
TDITENAATV SWTLPKSDGG SPITGYYMER REVTGKWVRV NKTPIADLKF RVTGLYEGNT 
YEFRVFAENL AGLSKPSPSS DPIKACRPIK PPGPPINPKL KDKSRETADL VWTKPLSDGG 
SPILGYVVEC QKPGTAQWNR INKDELIRQC AFRVPGLIEG NEYRFRIKAA NIVGEGEPRE 
LAESVIAKDI LHPPEVELDV TCRDVITVRV GQTIRILARV KGRPEPDITW TKEGKVLVRE 
KRVDLIQDLP RVELQIKEAV RADHGKYIIS AKNSSGHAQG SAIVNVLDRP GPCQNLKVTN 
VTKENCTISW ENPLDNGGSE ITNFIVEYRK PNQKGWSIVA SDVTKRLIKA NLLANNEYYF 
RVCAENKVGV GPTIETKTPI LAINPIDRPG EPENLHIADK GKTFVYLKWR RPDYDGGSPN 
LSYHVERRLK GSDDWERVHK GSIKETHYMV DRCVENQIYE FRVQTKNEGG ESDWVKTEEV 
VVKEDLQKPV LDLKLSGVLT VKAGDTIRLE AGVRGKPFPE VAWTKDKDAT DLTRSPRVKI 
DTRADSSKFS LTKAKRSDGG KYVVTATNTA GSFVAYATVN VLDKPGPVRN LKIVDVSSDR 
CTVCWDPPED DGGCEIQNYI LEKCETKRMV WSTYSATVLT PGTTVTRLIE GNEYIFRVRA 
ENKIGTGPPT ESKPVIAKTK YDKPGRPDPP EVTKVSKEEM TVVWNPPEYD GGKSITGYFL 
EKKEKHSTRW VPVNKSAIPE RRMKVQNLLP DHEYQFRVKA ENEIGIGEPS LPSRPVVAKD 
PIEPPGPPTN FRVVDTTKHS ITLGWGKPVY DGGAPIIGYV VEMRPKIADA SPDEGWKRCN 
AAAQLVRKEF TVTSLDENQE YEFRVCAQNQ VGIGRPAELK EAIKPKEILE PPEIDLDASM 
RKLVIVRAGC PIRLFAIVRG RPAPKVTWRK VGIDNVVRKG QVDLVDTMAF LVIPNSTRDD 
SGKYSLTLVN PAGEKAVFVN VRVLDTPGPV SDLKVSDVTK TSCHVSWAPP ENDGGSQVTH 
YIVEKREADR KTWSTVTPEV KKTSFHVTNL VPGNEYYFRV TAVNEYGPGV PTDVPKPVLA 
SDPLSEPDPP RKLEVTEMTK NSATLAWLPP LRDGGAKIDG YITSYREEEQ PADRWTEYSV 
VKDLSLVVTG LKEGKKYKFR VAARNAVGVS LPREAEGVYE AKEQLLPPKI LMPEQITIKA 
GKKLRIEAHV YGKPHPTCKW KKGEDEVVTS SHLAVHKADS SSILIIKDVT RKDSGYYSLT 
AENSSGTDTQ KIKVVVMDAP GPPQPPFDIS DIDADACSLS WHIPLEDGGS NITNYIVEKC 
DVSRGDWVTA LASVTKTSCR VGKLIPGQEY IFRVRAENRF GISEPLTSPK MVAQFPFGVP 
SEPKNARVTK VNKDCIFVAW DRPDSDGGSP IIGYLIERKE RNSLLWVKAN DTLVRSTEYP 
CAGLVEGLEY SFRIYALNKA GSSPPSKPTE YVTARMPVDP PGKPEVIDVT KSTVSLIWAR 
PKHDGGSKII GYFVEACKLP GDKWVRCNTA PHQIPQEEYT ATGLEEKAQY QFRAIARTAV 
NISPPSEPSD PVTILAENVP PRIDLSVAMK SLLTVKAGTN VCLDATVFGK PMPTVSWKKD 
GTLLKPAEGI KMAMQRNLCT LELFSVNRKD SGDYTITAEN SSGSKSATIK LKVLDKPGPP 
ASVKINKMYS DRAMLSWEPP LEDGGSEITN YIVDKRETSR PNWAQVSATV PITSCSVEKL 
IEGHEYQFRI CAENKYGVGD PVFTEPAIAK NPYDPPGRCD PPVISNITKD HMTVSWKPPA 
DDGGSPITGY LLEKRETQAV NWTKVNRKPI IERTLKATGL QEGTEYEFRV TAINKAGPGK 
PSDASKAAYA RDPQYPPGPP AFPKVYDTTR SSVSLSWGKP AYDGGSPIIG YLVEVKRADS 
DNWVRCNLPQ NLQKTRFEVT GLMEDTQYQF RVYAVNKIGY SDPSDVPDKH YPKDILIPPE 
GELDADLRKT LILRAGVTMR LYVPVKGRPP PKITWSKPNV NLRDRIGLDI KSTDFDTFLR 
CENVNKYDAG KYILTLENSC GKKEYTIVVK VLDTPGPPVN VTVKEISKDS AYVTWEPPII 
DGGSPIINYV VQKRDAERKS WSTVTTECSK TSFRVANLEE GKSYFFRVFA ENEYGIGDPG 
ETRDAVKASQ TPGPVVDLKV RSVSKSSCSI GWKKPHSDGG SRIIGYVVDF LTEENKWQRV 
MKSLSLQYSA KDLTEGKEYT FRVSAENENG EGTPSEITVV ARDDVVAPDL DLKGLPDLCY 
LAKENSNFRL KIPIKGKPAP SVSWKKGEDP LATDTRVSVE SSAVNTTLIV YDCQKSDAGK 
YTITLKNVAG TKEGTISIKV VGKPGIPTGP IKFDEVTAEA MTLKWAPPKD DGGSEITNYI 
LEKRDSVNNK WVTCASAVQK TTFRVTRLHE GMEYTFRVSA ENKYGVGEGL KSEPIVARHP 
FDVPDAPPPP NIVDVRHDSV SLTWTDPKKT GGSPITGYHL EFKERNSLLW KRANKTPIRM 
RDFKVTGLTE GLEYEFRVMA INLAGVGKPS LPSEPVVALD PIDPPGKPEV INITRNSVTL 
IWTEPKYDGG HKLTGYIVEK RDLPSKSWMK ANHVNVPECA FTVTDLVEGG KYEFRIRAKN 
TAGAISAPSE STETIICKDE YEAPTIVLDP TIKDGLTIKA GDTIVLNAIS ILGKPLPKSS 
WSKAGKDIRP SDITQITSTP TSSMLTIKYA TRKDAGEYTI TATNPFGTKV EHVKVTVLDV 
PGPPGPVEIS NVSAEKATLT WTPPLEDGGS PIKSYILEKR ETSRLLWTVV SEDIQSCRHV 
ATKLIQGNEY IFRVSAVNHY GKGEPVQSEP VKMVDRFGPP GPPEKPEVSN VTKNTATVSW 
KRPVDDGGSE ITGYHVERRE KKSLRWVRAI KTPVSDLRCK VTGLQEGSTY EFRVSAENRA 
GIGPPSEASD SVLMKDAAYP PGPPSNPHVT DTTKKSASLA WGKPHYDGGL EITGYVVEHQ 
KVGDEAWIKD TTGTALRITQ FVVPDLQTKE KYNFRISAIN DAGVGEPAVI PDVEIVEREM 
APDFELDAEL RRTLVVRAGL SIRIFVPIKG RPAPEVTWTK DNINLKNRAN IENTESFTLL 
IIPECNRYDT GKFVMTIENP AGKKSGFVNV RVLDTPGPVL NLRPTDITKD SVTLHWDLPL 
IDGGSRITNY IVEKREATRK SYSTATTKCH KCTYKVTGLS EGCEYFFRVM AENEYGIGEP 
TETTEPVKAS EAPSPPDSLN IMDITKSTVS LAWPKPKHDG GSKITGYVIE AQRKGSDQWT 
HITTVKGLEC VVRNLTEGEE YTFQVMAVNS AGRSAPRESR PVIVKEQTML PELDLRGIYQ 
KLVIAKAGDN IKVEIPVLGR PKPTVTWKKG DQILKQTQRV NFETTATSTI LNINECVRSD 
SGPYPLTARN IVGEVGDVIT IQVHDIPGPP TGPIKFDEVS SDFVTFSWDP PENDGGVPIS 
NYVVEMRQTD STTWVELATT VIRTTYKATR LTTGLEYQFR VKAQNRYGVG PGITSACIVA 
NYPFKVPGPP GTPQVTAVTK DSMTISWHEP LSDGGSPILG YHVERKERNG ILWQTVSKAL 
VPGNIFKSSG LTDGIAYEFR VIAENMAGKS KPSKPSEPML ALDPIDPPGK PVPLNITRHT 
VTLKWAKPEY TGGFKITSYI VEKRDLPNGR WLKANFSNIL ENEFTVSGLT EDAAYEFRVI 
AKNAAGAISP PSEPSDAITC RDDVEAPKIK VDVKFKDTVI LKAGEAFRLE ADVSGRPPPT 
MEWSKDGKEL EGTAKLEIKI ADFSTNLVNK DSTRRDSGAY TLTATNPGGF AKHIFNVKVL 
DRPGPPEGPL AVTEVTSEKC VLSWFPPLDD GGAKIDHYIV QKRETSRLAW TNVASEVQVT 
KLKVTKLLKG NEYIFRVMAV NKYGVGEPLE SEPVLAVNPY GPPDPPKNPE VTTITKDSMV 
VCWGHPDSDG GSEIINYIVE RRDKAGQRWI KCNKKTLTDL RYKVSGLTEG HEYEFRIMAE 
NAAGISAPSP TSPFYKACDT VFKPGPPGNP RVLDTSRSSI SIAWNKPIYD GGSEITGYMV 
EIALPEEDEW QIVTPPAGLK ATSYTITGLT ENQEYKIRIY AMNSEGLGEP ALVPGTPKAE 
DRMLPPEIEL DADLRKVVTI RACCTLRLFV PIKGRPAPEV KWARDHGESL DKASIESTSS 
YTLLIVGNVN RFDSGKYILT VENSSGSKSA FVNVRVLDTP GPPQDLKVKE VTKTSVTLTW 
DPPLLDGGSK IKNYIVEKRE STRKAYSTVA TNCHKTSWKV DQLQEGCSYY FRVLAENEYG 
IGLPAETAES VKASERPLPP GKITLMDVTR NSVSLSWEKP EHDGGSRILG YIVEMQTKGS 
DKWATCATVK VTEATITGLI QGEEYSFRVS AQNEKGISDP RQLSVPVIAK DLVIPPAFKL 
LFNTFTVLAG EDLKVDVPFI GRPTPAVTWH KDNVPLKQTT RVNAESTENN SLLTIKDACR 
EDVGHYVVKL TNSAGEAIET LNVIVLDKPG PPTGPVKMDE VTADSITLSW GPPKYDGGSS 
INNYIVEKRD TSTTTWQIVS ATVARTTIKA CRLKTGCEYQ FRIAAENRYG KSTYLNSEPT 
VAQYPFKVPG PPGTPVVTLS SRDSMEVQWN EPISDGGSRV IGYHLERKER NSILWVKLNK 
TPIPQTKFKT TGLEEGVEYE FRVSAENIVG IGKPSKVSEC YVARDPCDPP GRPEAIIVTR 
NSVTLQWKKP TYDGGSKITG YIVEKKELPE GRWMKASFTN IIDTHFEVTG LVEDHRYEFR 
VIARNAAGVF SEPSESTGAI TARDEVDPPR ISMDPKYKDT IVVHAGESFK VDADIYGKPI 
PTIQWIKGDQ ELSNTARLEI KSTDFATSLS VKDAVRVDSG NYILKAKNVA GERSVTVNVK 
VLDRPGPPEG PVVISGVTAE KCTLAWKPPL QDGGSDIINY IVERRETSRL VWTVVDANVQ 
TLSCKVTKLL EGNEYTFRIM AVNKYGVGEP LESEPVVAKN PFVVPDAPKA PEVTTVTKDS 
MIVVWERPAS DGGSEILGYV LEKRDKEGIR WTRCHKRLIG ELRLRVTGLI ENHDYEFRVS 
AENAAGLSEP SPPSAYQKAC DPIYKPGPPN NPKVIDITRS SVFLSWSKPI YDGGCEIQGY 
IVEKCDVSVG EWTMCTPPTG INKTNIEVEK LLEKHEYNFR ICAINKAGVG EHADVPGPII 
VEEKLEAPDI DLDLELRKII NIRAGGSLRL FVPIKGRPTP EVKWGKVDGE IRDAAIIDVT 
SSFTSLVLDN VNRYDSGKYT LTLENSSGTK SAFVTVRVLD TPSPPVNLKV TEITKDSVSI 
TWEPPLLDGG SKIKNYIVEK REATRKSYAA VVTNCHKNSW KIDQLQEGCS YYFRVTAENE 
YGIGLPAQTA DPIKVAEVPQ PPGKITVDDV TRNSVSLSWT KPEHDGGSKI IQYIVEMQAK 
HSEKWSECAR VKSLQAVITN LTQGEEYLFR VVAVNEKGRS DPRSLAVPIV AKDLVIEPDV 
KPAFSSYSVQ VGQDLKIEVP ISGRPKPTIT WTKDGLPLKQ TTRINVTDSL DLTTLSIKET 
HKDDGGQYGI TVANVVGQKT ASIEIVTLDK PDPPKGPVKF DDVSAESITL SWNPPLYTGG 
CQITNYIVQK RDTTTTVWDV VSATVARTTL KVTKLKTGTE YQFRIFAENR YGQSFALESD 
PIVAQYPYKE PGPPGTPFAT AISKDSMVIQ WHEPVNNGGS PVIGYHLERK ERNSILWTKV 
NKTIIHDTQF KAQNLEEGIE YEFRVYAENI VGVGKASKNS ECYVARDPCD PPGTPEPIMV 
KRNEITLQWT KPVYDGGSMI TGYIVEKRDL PDGRWMKASF TNVIETQFTV SGLTEDQRYE 
FRVIAKNAAG AISKPSDSTG PITAKDEVEL PRISMDPKFR DTIVVNAGET FRLEADVHGK 
PLPTIEWLRG DKEIEESARC EIKNTDFKAL LIVKDAIRID GGQYILRASN VAGSKSFPVN 
VKVLDRPGPP EGPVQVTGVT SEKCSLTWSP PLQDGGSDIS HYVVEKRETS RLAWTVVASE 
VVTNSLKVTK LLEGNEYVFR IMAVNKYGVG EPLESAPVLM KNPFVLPGPP KSLEVTNIAK 
DSMTVCWNRP DSDGGSEIIG YIVEKRDRSG IRWIKCNKRR ITDLRLRVTG LTEDHEYEFR 
VSAENAAGVG EPSPATVYYK ACDPVFKPGP PTNAHIVDTT KNSITLAWGK PIYDGGSEIL 
GYVVEICKAD EEEWQIVTPQ TGLRVTRFEI SKLTEHQEYK IRVCALNKVG LGEATSVPGT 
VKPEDKLEAP ELDLDSELRK GIVVRAGGSA RIHIPFKGRP TPEITWSREE GEFTDKVQIE 
KGVNYTQLSI DNCDRNDAGK YILKLENSSG SKSAFVTVKV LDTPGPPQNL AVKEVRKDSA 
FLVWEPPIID GGAKVKNYVI DKRESTRKAY ANVSSKCSKT SFKVENLTEG AIYYFRVMAE 
NEFGVGVPVE TVDAVKAAEP PSPPGKVTLT DVSQTSASLM WEKPEHDGGS RVLGYVVEMQ 
PKGTEKWSIV AESKVCNAVV TGLSSGQEYQ FRVKAYNEKG KSDPRVLGVP VIAKDLTIQP 
SLKLPFNTYS IQAGEDLKIE IPVIGRPRPN ISWVKDGEPL KQTTRVNVEE TATSTVLHIK 
EGNKDDFGKY TVTATNSAGT ATENLSVIVL EKPGPPVGPV RFDEVSADFV VISWEPPAYT 
GGCQISNYIV EKRDTTTTTW HMVSATVART TIKITKLKTG TEYQFRIFAE NRYGKSAPLD 
SKAVIVQYPF KEPGPPGTPF VTSISKDQML VQWHEPVNDG GTKIIGYHLE QKEKNSILWV 
KLNKTPIQDT KFKTTGLDEG LEYEFKVSAE NIVGIGKPSK VSECFVARDP CDPPGRPEAI 
VITRNNVTLK WKKPAYDGGS KITGYIVEKK DLPDGRWMKA SFTNVLETEF TVSGLVEDQR 
YEFRVIARNA AGNFSEPSDS SGAITARDEI DAPNASLDPK YKDVIVVHAG ETFVLEADIR 
GKPIPDVVWS KDGKELEETA ARMEIKSTIQ KTTLVVKDCI RTDGGQYILK LSNVGGTKSI 
PITVKVLDRP GPPEGPLKVT GVTAEKCYLA WNPPLQDGGA NISHYIIEKR ETSRLSWTQV 
STEVQALNYK VTKLLPGNEY IFRVMAVNKY GIGEPLESGP VTACNPYKPP GPPSTPEVSA 
ITKDSMVVTW ARPVDDGGTE IEGYILEKRD KEGVRWTKCN KKTLTDLRLR VTGLTEGHSY 
EFRVAAENAA GVGEPSEPSV FYRACDALYP PGPPSNPKVT DTSRSSVSLA WSKPIYDGGA 
PVKGYVVEVK EAAADEWTTC TPPTGLQGKQ FTVTKLKENT EYNFRICAIN SEGVGEPATL 
PGSVVAQERI EPPEIELDAD LRKVVVLRAS ATLRLFVTIK GRPEPEVKWE KAEGILTDRA 
QIEVTSSFTM LVIDNVTRFD SGRYNLTLEN NSGSKTAFVN VRVLDSPSAP VNLTIREVKK 
DSVTLSWEPP LIDGGAKITN YIVEKRETTR KAYATITNNC TKTTFRIENL QEGCSYYFRV 
LASNEYGIGL PAETTEPVKV SEPPLPPGRV TLVDVTRNTA TIKWEKPESD GGSKITGYVV 
EMQTKGSEKW STCTQVKTLE ATISGLTAGE EYVFRVAAVN EKGRSDPRQL GVPVIARDIE 
IKPSVELPFH TFNVKAREQL KIDVPFKGRP QATVNWRKDG QTLKETTRVN VSSSKTVTSL 
SIKEASKEDV GTYELCVSNS AGSITVPITI IVLDRPGPPG PIRIDEVSCD SITISWNPPE 
YDGGCQISNY IVEKKETTST TWHIVSQAVA RTSIKIVRLT TGSEYQFRVC AENRYGKSSY 
SESSAVVAEY PFSPPGPPGT PKVVHATKST MLVTWQVPVN DGGSRVIGYH LEYKERSSIL 
WSKANKILIA DTQMKVSGLD EGLMYEYRVY AENIAGIGKC SKSCEPVPAR DPCDPPGQPE 
VTNITRKSVS LKWSKPHYDG GAKITGYIVE RRELPDGRWL KCNYTNIQET YFEVTELTED 
QRYEFRVFAR NAADSVSEPS ESTGPIIVKD DVEPPRVMMD VKFRDVIVVK AGEVLKINAD 
IAGRPLPVIS WAKDGIEIEE RARTEIISTD NHTLLTVKDC IRRDTGQYVL TLKNVAGTRS 
VAVNCKVLDK PGPPAGPLEI NGLTAEKCSL SWGRPQEDGG ADIDYYIVEK RETSHLAWTI 
CEGELQMTSC KVTKLLKGNE YIFRVTGVNK YGVGEPLESV AIKALDPFTV PSPPTSLEIT 
SVTKESMTLC WSRPESDGGS EISGYIIERR EKNSLRWVRV NKKPVYDLRV KSTGLREGCE 
YEYRVYAENA AGLSLPSETS PLIRAEDPVF LPSPPSKPKI VDSGKTTITI AWVKPLFDGG 
APITGYTVEY KKSDDTDWKT SIQSLRGTEY TISGLTTGAE YVFRVKSVNK VGASDPSDSS 
DPQIAKEREE EPLFDIDSEM RKTLIVKAGA SFTMTVPFRG RPVPNVLWSK PDTDLRTRAY 
VDTTDSRTSL TIENANRNDS GKYTLTIQNV LSAASLTLVV KVLDTPGPPT NITVQDVTKE 
SAVLSWDVPE NDGGAPVKNY HIEKREASKK AWVSVTNNCN RLSYKVTNLQ EGAIYYFRVS 
GENEFGVGIP AETKEGVKIT EKPSPPEKLG VTSISKDSVS LTWLKPEHDG GSRIVHYVVE 
ALEKGQKNWV KCAVAKSTHH VVSGLRENSE YFFRVFAENQ AGLSDPRELL LPVLIKEQLE 
PPEIDMKNFP SHTVYVRAGS NLKVDIPISG KPLPKVTLSR DGVPLKATMR FNTEITAENL 
TINLKESVTA DAGRYEITAA NSSGTTKAFI NIVVLDRPGP PTGPVVISDI TEESVTLKWE 
PPKYDGGSQV TNYILLKRET STAVWTEVSA TVARTMMKVM KLTTGEEYQF RIKAENRFGI 
SDHIDSACVT VKLPYTTPGP PSTPWVTNVT RESITVGWHE PVSNGGSAVV GYHLEMKDRN 
SILWQKANKL VIRTTHFKVT TISAGLIYEF RVYAENAAGV GKPSHPSEPV LAIDACEPPR 
NVRITDISKN SVSLSWQQPA FDGGSKITGY IVERRDLPDG RWTKASFTNV TETQFIISGL 
TQNSQYEFRV FARNAVGSIS NPSEVVGPIT CIDSYGGPVI DLPLEYTEVV KYRAGTSVKL 
RAGISGKPAP TIEWYKDDKE LQTNALVCVE NTTDLASILI KDADRLNSGC YELKLRNAMG 
SASATIRVQI LDKPGPPGGP IEFKTVTAEK ITLLWRPPAD DGGAKITHYI VEKRETSRVV 
WSMVSEHLEE CIITTTKIIK GNEYIFRVRA VNKYGIGEPL ESDSVVAKNA FVTPGPPGIP 
EVTKITKNSM TVVWSRPIAD GGSDISGYFL EKRDKKSLGW FKVLKETIRD TRQKVTGLTE 
NSDYQYRVCA VNAAGQGPFS EPSEFYKAAD PIDPPGPPAK IRIADSTKSS ITLGWSKPVY 
DGGSAVTGYV VEIRQGEEEE WTTVSTKGEV RTTEYVVSNL KPGVNYYFRV SAVNCAGQGE 
PIEMNEPVQA KDILEAPEID LDVALRTSVI AKAGEDVQVL IPFKGRPPPT VTWRKDEKNL 
GSDARYSIEN TDSSSLLTIP QVTRNDTGKY ILTIENGVGE PKSSTVSVKV LDTPAACQKL 
QVKHVSRGTV TLLWDPPLID GGSPIINYVI EKRDATKRTW SVVSHKCSST SFKLIDLSEK 
TPFFFRVLAE NEIGIGEPCE TTEPVKAAEV PAPIRDLSMK DSTKTSVILS WTKPDFDGGS 
VITEYVVERK GKGEQTWSHA GISKTCEIEV SQLKEQSVLE FRVFAKNEKG LSDPVTIGPI 
TVKELIITPE VDLSDIPGAQ VTVRIGHNVH LELPYKGKPK PSISWLKDGL PLKESEFVRF 
SKTENKITLS IKNAKKEHGG KYTVILDNAV CRIAVPITVI TLGPPSKPKG PIRFDEIKAD 
SVILSWDVPE DNGGGEITCY SIEKRETSQT NWKMVCSSVA RTTFKVPNLV KDAEYQFRVR 
AENRYGVSQP LVSSIIVAKH QFRIPGPPGK PVIYNVTSDG MSLTWDAPVY DGGSEVTGFH 
VEKKERNSIL WQKVNTSPIS GREYRATGLV EGLDYQFRVY AENSAGLSSP SDPSKFTLAV 
SPVDPPGTPD YIDVTRETIT LKWNPPLRDG GSKIVGYSIE KRQGNERWVR CNFTDVSECQ 
YTVTGLSPGD RYEFRIIARN AVGTISPPSQ SSGIIMTRDE NVPPIVEFGP EYFDGLIIKS 
GESLRIKALV QGRPVPRVTW FKDGVEIEKR MNMEITDVLG STSLFVRDAT RDHRGVYTVE 
AKNASGSAKA EIKVKVQDTP GKVVGPIRFT NITGEKMTLW WDAPLNDGCA PITHYIIEKR 
ETSRLAWALI EDKCEAQSYT AIKLINGNEY QFRVSAVNKF GVGRPLDSDP VVAQIQYTVP 
DAPGIPEPSN ITGNSITLTW ARPESDGGSE IQQYILERRE KKSTRWVKVI SKRPISETRF 
KVTGLTEGNE YEFHVMAENA AGVGPASGIS RLIKCREPVN PPGPPTVVKV TDTSKTTVSL 
EWSKPVFDGG MEIIGYIIEM CKADLGDWHK VNAEACVKTR YTVTDLQAGE EYKFRVSAIN 
GAGKGDSCEV TGTIKAVDRL TAPELDIDAN FKQTHVVRAG ASIRLFIAYQ GRPTPTAVWS 
KPDSNLSLRA DIHTTDSFST LTVENCNRND AGKYTLTVEN NSGSKSITFT VKVLDTPGPP 
GPITFKDVTR GSATLMWDAP LLDGGARIHH YVVEKREASR RSWQVISEKC TRQIFKVNDL 
AEGVPYYFRV SAVNEYGVGE PYEMPEPIVA TEQPAPPRRL DVVDTSKSSA VLAWLKPDHD 
GGSRITGYLL EMRQKGSDFW VEAGHTKQLT FTVERLVEKT EYEFRVKAKN DAGYSEPREA 
FSSVIIKEPQ IEPTADLTGI TNQLITCKAG SPFTIDVPIS GRPAPKVTWK LEEMRLKETD 
RVSITTTKDR TTLTVKDSMR GDSGRYFLTL ENTAGVKTFS VTVVVIGRPG PVTGPIEVSS 
VSAESCVLSW GEPKDGGGTE ITNYIVEKRE SGTTAWQLVN SSVKRTQIKV THLTKYMEYS 
FRVSSENRFG VSKPLESAPI IAEHPFVPPS APTRPEVYHV SANAMSIRWE EPYHDGGSKI 
IGYWVEKKER NTILWVKENK VPCLECNYKV TGLVEGLEYQ FRTYALNAAG VSKASEASRP 
IMAQNPVDAP GRPEVTDVTR STVSLIWSAP AYDGGSKVVG YIIERKPVSE VGDGRWLKCN 
YTIVSDNFFT VTALSEGDTY EFRVLAKNAA GVISKGSEST GPVTCRDEYA PPKAELDARL 
HGDLVTIRAG SDLVLDAAVG GKPEPKIIWT KGDKELDLCE KVSLQYTGKR ATAVIKFCDR 
SDSGKYTLTV KNASGTKAVS VMVKVLDSPG PCGKLTVSRV TQEKCTLAWS LPQEDGGAEI 
THYIVERRET SRLNWVIVEG ECPTLSYVVT RLIKNNEYIF RVRAVNKYGP GVPVESEPIV 
ARNSFTIPSP PGIPEEVGTG KEHIIIQWTK PESDGGNEIS NYLVDKREKK SLRWTRVNKD 
YVVYDTRLKV TSLMEGCDYQ FRVTAVNAAG NSEPSEASNF ISCREPSYTP GPPSAPRVVD 
TTKHSISLAW TKPMYDGGTD IVGYVLEMQE KDTDQWYRVH TNATIRNTEF TVPDLKMGQK 
YSFRVAAVNV KGMSEYSESI AEIEPVERIE IPDLELADDL KKTVTIRAGA SLRLMVSVSG 
RPPPVITWSK QGIDLASRAI IDTTESYSLL IVDKVNRYDA GKYTIEAENQ SGKKSATVLV 
KVYDTPGPCP SVKVKEVSRD SVTITWEIPT IDGGAPVNNY IVEKREAAMR AFKTVTTKCS 
KTLYRISGLV EGTMYYFRVL PENIYGIGEP CETSDAVLVS EVPLVPAKLE VVDVTKSTVT 
LAWEKPLYDG GSRLTGYVLE ACKAGTERWM KVVTLKPTVL EHTVTSLNEG EQYLFRIRAQ 
NEKGVSEPRE TVTAVTVQDL RVLPTIDLST MPQKTIHVPA GRPVELVIPI AGRPPPAASW 
FFAGSKLRES ERVTVETHTK VAKLTIRETT IRDTGEYTLE LKNVTGTTSE TIKVIILDKP 
GPPTGPIKID EIDATSITIS WEPPELDGGA PLSGYVVEQR DAHRPGWLPV SESVTRSTFK 
FTRLTEGNEY VFRVAATNRF GIGSYLQSEV IECRSSIRIP GPPETLQIFD VSRDGMTLTW 
YPPEDDGGSQ VTGYIVERKE VRADRWVRVN KVPVTMTRYR STGLTEGLEY EHRVTAINAR 
GSGKPSRPSK PIVAMDPIAP PGKPQNPRVT DTTRTSVSLA WSVPEDEGGS KVTGYLIEMQ 
KVDQHEWTKC NTTPTKIREY TLTHLPQGAE YRFRVLACNA GGPGEPAEVP GTVKVTEMLE 
YPDYELDERY QEGIFVRQGG VIRLTIPIKG KPFPICKWTK EGQDISKRAM IATSETHTEL 
VIKEADRGDS GTYDLVLENK CGKKAVYIKV RVIGSPNSPE GPLEYDDIQV RSVRVSWRPP 
ADDGGADILG YILERREVPK AAWYTIDSRV RGTSLVVKGL KENVEYHFRV SAENQFGISK 
PLKSEEPVTP KTPLNPPEPP SNPPEVLDVT KSSVSLSWSR PKDDGGSRVT GYYIERKETS 
TDKWVRHNKT QITTTMYTVT GLVPDAEYQF RIIAQNDVGL SETSPASEPV VCKDPFDKPS 
QPGELEILSI SKDSVTLQWE KPECDGGKEI LGYWVEYRQS GDSAWKKSNK ERIKDKQFTI 
GGLLEATEYE FRVFAENETG LSRPRRTAMS IKTKLTSGEA PGIRKEMKDV TTKLGEAAQL 
SCQIVGRPLP DIKWYRFGKE LIQSRKYKMS SDGRTHTLTV MTEEQEDEGV YTCIATNEVG 
EVETSSKLLL QATPQFHPGY PLKEKYYGAV GSTLRLHVMY IGRPVPAMTW FHGQKLLQNS 
ENITIENTEH YTHLVMKNVQ RKTHAGKYKV QLSNVFGTVD AILDVEIQDK PDKPTGPIVI 
EALLKNSAVI SWKPPADDGG SWITNYVVEK CEAKEGAEWQ LVSSAISVTT CRIVNLTENA 
GYYFRVSAQN TFGISDPLEV SSVVIIKSPF EKPGAPGKPT ITAVTKDSCV VAWKPPASDG 
GAKIRNYYLE KREKKQNKWI SVTTEEIRET VFSVKNLIEG LEYEFRVKCE NLGGESEWSE 
ISEPITPKSD VPIQAPHFKE ELRNLNVRYQ SNATLVCKVT GHPKPIVKWY RQGKEIIADG 
LKYRIQEFKG GYHQLIIASV TDDDATVYQV RATNQGGSVS GTASLEVEVP AKIHLPKTLE 
GMGAVHALRG EVVSIKIPFS GKPDPVITWQ KGQDLIDNNG HYQVIVTRSF TSLVFPNGVE 
RKDAGFYVVC AKNRFGIDQK TVELDVADVP DPPRGVKVSD VSRDSVNLTW TEPASDGGSK 
ITNYIVEKCA TTAERWLRVG QARETRYTVI NLFGKTSYQF RVIAENKFGL SKPSEPSEPT 
ITKEDKTRAM NYDEEVDETR EVSMTKASHS STKELYEKYM IAEDLGRGEF GIVHRCVETS 
SKKTYMAKFV KVKGTDQVLV KKEISILNIA RHRNILHLHE SFESMEELVM IFEFISGLDI 
FERINTSAFE LNEREIVSYV HQVCEALQFL HSHNIGHFDI RPENIIYQTR RSSTIKIIEF 
GQARQLKPGD NFRLLFTAPE YYAPEVHQHD VVSTATDMWS LGTLVYVLLS GINPFLAETN 
QQIIENIMNA EYTFDEEAFK EISIEAMDFV DRLLVKERKS RMTASEALQH PWLKQKIERV 
STKVIRTLKH RRYYHTLIKK DLNMVVSAAR ISCGGAIRSQ KGVSVAKVKV ASIEIGPVSG 
QIMHAVGEEG GHVKYVCKIE NYDQSTQVTW YFGVRQLENS EKYEITYEDG VAILYVKDIT 
KLDDGTYRCK VVNDYGEDSS YAELFVKGVR EVYDYYCRRT MKKIKRRTDT MRLLERPPEF 
TLPLYNKTAY VGENVRFGVT ITVHPEPHVT WYKSGQKIKP GDNDKKYTFE SDKGLYQLTI 
NSVTTDDDAE YTVVARNKYG EDSCKAKLTV TLHPPPTDST LRPMFKRLLA NAECQEGQSV 
CFEIRVSGIP PPTLKWEKDG QPLSLGPNIE IIHEGLDYYA LHIRDTLPED TGYYRVTATN 
TAGSTSCQAH LQVERLRYKK QEFKSKEEHE RHVQKQIDKT LRMAEILSGT ESVPLTQVAK 
EALREAAVLY KPAVSTKTVK GEFRLEIEEK KEERKLRMPY DVPEPRKYKQ TTIEEDQRIK 
QFVPMSDMKW YKKIRDQYEM PGKLDRVVQK RPKRIRLSRW EQFYVMPLPR ITDQYRPKWR 
IPKLSQDDLE IVRPARRRTP SPDYDFYYRP RRRSLGDISD EELLLPIDDY LAMKRTEEER 
LRLEEELELG FSASPPSRSP PHFELSSLRY SSPQAHVKVE ETRKDFRYST YHIPTKAEAS 
TSYAELRERH AQAAYRQPKQ RQRIMAERED EELLRPVTTT QHLSEYKSEL DFMSKEEKSR 
KKSRRQREVT EITEIEEEYE ISKHAQRESS SSASRLLRRR RSLSPTYIEL MRPVSELIRS 
RPQPAEEYED DTERRSPTPE RTRPRSPSPV SSERSLSRFE RSARFDIFSR YESMKAALKT 
QKTSERKYEV LSQQPFTLDH APRITLRMRS HRVPCGQNTR FILNVQSKPT AEVKWYHNGV 
ELQESSKIHY TNTSGVLTLE ILDCHTDDSG TYRAVCTNYK GEASDYATLD VTGGDYTTYA 
SQRRDEEVPR SVFPELTRTE AYAVSSFKKT SEMEASSSVR EVKSQMTETR ESLSSYEHSA 
SAEMKSAALE EKSLEEKSTT RKIKTTLAAR ILTKPRSMTV YEGESARFSC DTDGEPVPTV 
TWLRKGQVLS TSARHQVTTT KYKSTFEISS VQASDEGNYS VVVENSEGKQ EAEFTLTIQK 
ARVTEKAVTS PPRVKSPEPR VKSPEAVKSP KRVKSPEPSH PKAVSPTETK PTPTEKVQHL 
PVSAPPKITQ FLKAEASKEI AKLTCVVESS VLRAKEVTWY KDGKKLKENG HFQFHYSADG 
TYELKINNLT ESDQGEYVCE ISGEGGTSKT NLQFMGQAFK SIHEKVSKIS ETKKSDQKTT 
ESTVTRKTEP KAPEPISSKP VIVTGLQDTT VSSDSVAKFA VKATGEPRPT AIWTKDGKAI 
TQGGKYKLSE DKGGFFLEIH KTDTSDSGLY TCTVKNSAGS VSSSCKLTIK AIKDTEAQKV 
STQKTSEITP QKKAVVQEEI SQKALRSEEI KMSEAKSQEK LALKEEASKV LISEEVKKSA 
ATSLEKSIVH EEITKTSQAS EEVRTHAEIK AFSTQMSINE GQRLVLKANI AGATDVKWVL 
NGVELTNSEE YRYGVSGSDQ TLTIKQASHR DEGILTCISK TKEGIVKCQY DLTLSKELSD 
APAFISQPRS QNINEGQNVL FTCEISGEPS PEIEWFKNNL PISISSNVSI SRSRNVYSLE 
IRNASVSDSG KYTIKAKNFR GQCSATASLM VLPLVEEPSR EVVLRTSGDT SLQGSFSSQS 
VQMSASKQEA SFSSFSSSSA SSMTEMKFAS MSAQSMSSMQ ESFVEMSSSS FMGISNMTQL 
ESSTSKMLKA GIRGIPPKIE ALPSDISIDE GKVLTVACAF TGEPTPEVTW SCGGRKIHSQ 
EQGRFHIENT DDLTTLIIMD VQKQDGGLYT LSLGNEFGSD SATVNIHIRS I

Genular Protein ID: 2921893806

Symbol: A0A0A0MRA3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MRA3

Database IDs:

ARBA 6 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 9 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 2 GeneTree 1 HGNC 1 InterPro 13 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 7 PeptideAtlas 2 Pfam 4 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 4 SUPFAM 3 UCSC 1 VEuPathDB 1 iPTMnet 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

Sequence Information:

  • Length: 27118
  • Mass: 3013987
  • Checksum: AE72600A05927F9D
  • Sequence:
    • MTTQAPTFTQ PLQSVVVLEG STATFEAHIS GFPVPEVSWF RDGQVISTST LPGVQISFSD 
GRAKLTIPAV TKANSGRYSL KATNGSGQAT STAELLVKAE TAPPNFVQRL QSMTVRQGSQ 
VRLQVRVTGI PTPVVKFYRD GAEIQSSLDF QISQEGDLYS LLIAEAYPED SGTYSVNATN 
SVGRATSTAE LLVQGEEEVP AKKTKTIVST AQISESRQTR IEKKIEAHFD ARSIATVEMV 
IDGAAGQQLP HKTPPRIPPK PKSRSPTPPS IAAKAQLARQ QSPSPIRHSP SPVRHVRAPT 
PSPVRSVSPA ARISTSPIRS VRSPLLMRKT QASTVATGPE VPPPWKQEGY VASSSEAEMR 
ETTLTTSTQI RTEERWEGRY GVQEQVTISG AAGAAASVSA SASYAAEAVA TGAKEVKQDA 
DKSAAVATVV AAVDMARVRE PVISAVEQTA QRTTTTAVHI QPAQEQVRKE AEKTAVTKVV 
VAADKAKEQE LKSRTKEVIT TKQEQMHVTH EQIRKETEKT FVPKVVISAA KAKEQETRIS 
EEITKKQKQV TQEAIMKETR KTVVPKVIVA TPKVKEQDLV SRGREGITTK REQVQITQEK 
MRKEAEKTAL STIAVATAKA KEQETILRTR ETMATRQEQI QVTHGKVDVG KKAEAVATVV 
AAVDQARVRE PREPGHLEES YAQQTTLEYG YKERISAAKV AEPPQRPASE PHVVPKAVKP 
RVIQAPSETH IKTTDQKGMH ISSQIKKTTD LTTERLVHVD KRPRTASPHF TVSKISVPKT 
EHGYEASIAG SAIATLQKEL SATSSAQKIT KSVKAPTVKP SETRVRAEPT PLPQFPFADT 
PDTYKSEAGV EVKKEVGVSI TGTTVREERF EVLHGREAKV TETARVPAPV EIPVTPPTLV 
SGLKNVTVIE GESVTLECHI SGYPSPTVTW YREDYQIESS IDFQITFQSG IARLMIREAF 
AEDSGRFTCS AVNEAGTVST SCYLAVQVSE EFEKETTAVT EKFTTEEKRF VESRDVVMTD 
TSLTEEQAGP GEPAAPYFIT KPVVQKLVEG GSVVFGCQVG GNPKPHVYWK KSGVPLTTGY 
RYKVSYNKQT GECKLVISMT FADDAGEYTI VVRNKHGETS ASASLLEEAD YELLMKSQQE 
MLYQTQVTAF VQEPKVGETA PGFVYSEYEK EYEKEQALIR KKMAKDTVVV RTYVEDQEFH 
ISSFEERLIK EIEYRIIKTT LEELLEEDGE EKMAVDISES EAVESGFDSR IKNYRILEGM 
GVTFHCKMSG YPLPKIAWYK DGKRIKHGER YQMDFLQDGR ASLRIPVVLP EDEGIYTAFA 
SNIKGNAICS GKLYVEPAAP LGAPTYIPTL EPVSRIRSLS PRSVSRSPIR MSPARMSPAR 
MSPARMSPAR MSPGRRLEET DESQLERLYK PVFVLKPVSF KCLEGQTARF DLKVVGRPMP 
ETFWFHDGQQ IVNDYTHKVV IKEDGTQSLI IVPATPSDSG EWTVVAQNRA GRSSISVILT 
VEAVEHQVKP MFVEKLKNVN IKEGSRLEMK VRATGNPNPD IVWLKNSDII VPHKYPKIRI 
EGTKGEAALK IDSTVSQDSA WYTATAINKA GRDTTRCKVN VEVEFAEPEP ERKLIIPRGT 
YRAKEIAAPE LEPLHLRYGQ EQWEEGDLYD KEKQQKPFFK KKLTSLRLKR FGPAHFECRL 
TPIGDPTMVV EWLHDGKPLE AANRLRMINE FGYCSLDYGV AYSRDSGIIT CRATNKYGTD 
HTSATLIVKD EKSLVEESQL PEGRKGLQRI EELERMAHEG ALTGVTTDQK EKQKPDIVLY 
PEPVRVLEGE TARFRCRVTG YPQPKVNWYL NGQLIRKSKR FRVRYDGIHY LDIVDCKSYD 
TGEVKVTAEN PEGVIEHKVK LEIQQREDFR SVLRRAPEPR PEFHVHEPGK LQFEVQKVDR 
PVDTTETKEV VKLKRAERIT HEKVPEESEE LRSKFKRRTE EGYYEAITAV ELKSRKKDES 
YEELLRKTKD ELLHWTKELT EEEKKALAEE GKITIPTFKP DKIELSPSME APKIFERIQS 
QTVGQGSDAH FRVRVVGKPD PECEWYKNGV KIERSDRIYW YWPEDNVCEL VIRDVTAEDS 
ASIMVKAINI AGETSSHAFL LVQAKQLITF TQELQDVVAK EKDTMATFEC ETSEPFVKVK 
WYKDGMEVHE GDKYRMHSDR KVHFLSILTI DTSDAEDYSC VLVEDENVKT TAKLIVEGAV 
VEFVKELQDI EVPESYSGEL ECIVSPENIE GKWYHNDVEL KSNGKYTITS RRGRQNLTVK 
DVTKEDQGEY SFVIDGKKTT CKLKMKPRPI AILQGLSDQK VCEGDIVQLE VKVSLESVEG 
VWMKDGQEVQ PSDRVHIVID KQSHMLLIED MTKEDAGNYS FTIPALGLST SGRVSVYSVD 
VITPLKDVNV IEGTKAVLEC KVSVPDVTSV KWYLNDEQIK PDDRVQAIVK GTKQRLVINR 
THASDEGPYK LIVGRVETNC NLSVEKIKII RGLRDLTCTE TQNVVFEVEL SHSGIDVLWN 
FKDKEIKPSS KYKIEAHGKI YKLTVLNMMK DDEGKYTFYA GENMTSGKLT VAGGAISKPL 
TDQTVAESQE AVFECEVANP DSKGEWLRDG KHLPLTNNIR SESDGHKRRL IIAATKLDDI 
GEYTYKVATS KTSAKLKVEA VKIKKTLKNL TVTETQDAVF TVELTHPNVK GVQWIKNGVV 
LESNEKYAIS VKGTIYSLRI KNCAIVDESV YGFRLGRLGA SARLHVETVK IIKKPKDVTA 
LENATVAFEV SVSHDTVPVK WFHKSVEIKP SDKHRLVSER KVHKLMLQNI SPSDAGEYTA 
VVGQLECKAK LFVETLHITK TMKNIEVPET KTASFECEVS HFNVPSMWLK NGVEIEMSEK 
FKIVVQGKLH QLIIMNTSTE DSAEYTFVCG NDQVSATLTV TPIMITSMLK DINAEEKDTI 
TFEVTVNYEG ISYKWLKNGV EIKSTDKCQM RTKKLTHSLN IRNVHFGDAA DYTFVAGKAT 
STATLYVEAR HIEFRKHIKD IKVLEKKRAM FECEVSEPDI TVQWMKDDQE LQITDRIKIQ 
KEKYVHRLLI PSTRMSDAGK YTVVAGGNVS TAKLFVEGRD VRIRSIKKEV QVIEKQRAVV 
EFEVNEDDVD AHWYKDGIEI NFQVQERHKY VVERRIHRMF ISETRQSDAG EYTFVAGRNR 
SSVTLYVNAP EPPQVLQELQ PVTVQSGKPA RFCAVISGRP QPKISWYKEE QLLSTGFKCK 
FLHDGQEYTL LLIEAFPEDA AVYTCEAKND YGVATTSASL SVEVPEVVSP DQEMPVYPPA 
IITPLQDTVT SEGQPARFQC RVSGTDLKVS WYSKDKKIKP SRFFRMTQFE DTYQLEIAEA 
YPEDEGTYTF VASNAVGQVS STANLSLEVQ ALDRQSSGKD VRESTKSQAV ADSSFTKEES 
KISQKEIKSF QGSSYEYEVQ VFESVSQSSI HTAASVQDTQ LCHTASLSQI AESTELSKEC 
AKESTGEAPK IFLHLQDVTV KCGDTAQFLC VLKDDSFIDV TWTHEGAKIE ESERLKQSQN 
GNIQFLTICN VQLVDQGLYS CIVHNDCGER TTSAVLSVEG APESILHERI EQEIEMEMKE 
FSSSFLSAEE EGLHSAELQL SKINETLELL SESPVYPTKF DSEKEGTGPI FIKEVSNADI 
SMGDVATLSV TVIGIPKPKI QWFFNGVLLT PSADYKFVFD GDDHSLIILF TKLEDEGEYT 
CMASNDYGKT ICSAYLKINS KGEGHKDTET ESAVAKSLEK LGGPCPPHFL KELKPIRCAQ 
GLPAIFEYTV VGEPAPTVTW FKENKQLCTS VYYTIIHNPN GSGTFIVNDP QREDSGLYIC 
KAENMLGEST CAAELLVLLE DTDMTDTPCK AKSTPEAPED FPQTPLKGPA VEALDSEQEI 
ATFVKDTILK AALITEENQQ LSYEHIAKAN ELSSQLPLGA QELQSILEQD KLTPESTREF 
LCINGSIHFQ PLKEPSPNLQ LQIVQSQKTF SKEGILMPEE PETQAVLSDT EKIFPSAMSI 
EQINSLTVEP LKTLLAEPEG NYPQSSIEPP MHSYLTSVAE EVLSPKEKTV SDTNREQRVT 
LQKQEAQSAL ILSQSLAEGH VESLQSPDVM ISQVNYEPLV PSEHSCTEGG KILIESANPL 
ENAGQDSAVR IEEGKSLRFP LALEEKQVLL KEEHSDNVVM PPDQIIESKR EPVAIKKVQE 
VQGRDLLSKE SLLSGIPEEQ RLNLKIQICR ALQAAVASEQ PGLFSEWLRN IEKVEVEAVN 
ITQEPRHIMC MYLVTSAKSV TEEVTIIIED VDPQMANLKM ELRDALCAII YEEIDILTAE 
GPRIQQGAKT SLQEEMDSFS GSQKVEPITE PEVESKYLIS TEEVSYFNVQ SRVKYLDATP 
VTKGVASAVV SDEKQDESLK PSEEKEESSS ESGTEEVATV KIQEAEGGLI KEDGPMIHTP 
LVDTVSEEGD IVHLTTSITN AKEVNWYFEN KLVPSDEKFK CLQDQNTYTL VIDKVNTEDH 
QGEYVCEALN DSGKTATSAK LTVVKRAAPV IKRKIEPLEV ALGHLAKFTC EIQSAPNVRF 
QWFKAGREIY ESDKCSIRSS KYISSLEILR TQVVDCGEYT CKASNEYGSV SCTATLTVTV 
PGGEKKVRKL LPERKPEPKE EVVLKSVLRK RPEEEEPKVE PKKLEKVKKP AVPEPPPPKP 
VEEVEVPTVT KRERKIPEPT KVPEIKPAIP LPAPEPKPKP EAEVKTIKPP PVEPEPTPIA 
APVTVPVVGK KAEAKAPKEE AAKPKGPIKG VPKKTPSPIE AERRKLRPGS GGEKPPDEAP 
FTYQLKAVPL KFVKEIKDII LTESEFVGSS AIFECLVSPS TAITTWMKDG SNIRESPKHR 
FIADGKDRKL HIIDVQLSDA GEYTCVLRLG NKEKTSTAKL VVEELPVRFV KTLEEEVTVV 
KGQPLYLSCE LNKERDVVWR KDGKIVVEKP GRIVPGVIGL MRALTINDAD DTDAGTYTVT 
VENANNLECS SCVKVVEVIR DWLVKPIRDQ HVKPKGTAIF ACDIAKDTPN IKWFKGYDEI 
PAEPNDKTEI LRDGNHLYLK IKNAMPEDIA EYAVEIEGKR YPAKLTLGER EVELLKPIED 
VTIYEKESAS FDAEISEADI PGQWKLKGEL LRPSPTCEIK AEGGKRFLTL HKVKLDQAGE 
VLYQALNAIT TAILTVKEIE LDFAVPLKDV TVPERRQARF ECVLTREANV IWSKGPDIIK 
SSDKFDIIAD GKKHILVIND SQFDDEGVYT AEVEGKKTSA RLFVTGIRLK FMSPLEDQTV 
KEGETATFVC ELSHEKMHVV WFKNDAKLHT SRTVLISSEG KTHKLEMKEV TLDDISQIKA 
QVKELSSTAQ LKVLEADPYF TVKLHDKTAV EKDEITLKCE VSKDVPVKWF KDGEEIVPSP 
KYSIKADGLR RILKIKKADL KDKGEYVCDC GTDKTKANVT VEARLIKVEK PLYGVEVFVG 
ETAHFEIELS EPDVHGQWKL KGQPLTASPD CEIIEDGKKH ILILHNCQLG MTGEVSFQAA 
NAKSAANLKV KELPLIFITP LSDVKVFEKD EAKFECEVSR EPKTFRWLKG TQEITGDDRF 
ELIKDGTKHS MVIKSAAFED EAKYMFEAED KHTSGKLIIE GIRLKFLTPL KDVTAKEKES 
AVFTVELSHD NIRVKWFKND QRLHTTRSVS MQDEGKTHSI TFKDLSIDDT SQIRVEAMGM 
SSEAKLTVLE GDPYFTGKLQ DYTGVEKDEV ILQCEISKAD APVKWFKDGK EIKPSKNAVI 
KADGKKRMLI LKKALKSDIG QYTCDCGTDK TSGKLDIEDR EIKLVRPLHS VEVMETETAR 
FETEISEDDI HANWKLKGEA LLQTPDCEIK EEGKIHSLVL HNCRLDQTGG VDFQAANVKS 
SAHLRVKPRV IGLLRPLKDV TVTAGETATF DCELSYEDIP VEWYLKGKKL EPSDKVVPRS 
EGKVHTLTLR DVKLEDAGEV QLTAKDFKTH ANLFVKEPPV EFTKPLEDQT VEEGATAVLE 
CEVSRENAKV KWFKNGTEIL KSKKYEIVAD GRVRKLVIHD CTPEDIKTYT CDAKDFKTSC 
NLNVVPPHVE FLRPLTDLQV REKEMARFEC ELSRENAKVK WFKDGAEIKK GKKYDIISKG 
AVRILVINKC LLDDEAEYSC EVRTARTSGM LTVLEEEAVF TKNLANIEVS ETDTIKLVCE 
VSKPGAEVIW YKGDEEIIET GRYEILTEGR KRILVIQNAH LEDAGNYNCR LPSSRTDGKV 
KVHELAAEFI SKPQNLEILE GEKAEFVCSI SKESFPVQWK RDDKTLESGD KYDVIADGKK 
RVLVVKDATL QDMGTYVVMV GAARAAAHLT VIEKLRIVVP LKDTRVKEQQ EVVFNCEVNT 
EGAKAKWFRN EEAIFDSSKY IILQKDLVYT LRIRDAHLDD QANYNVSLTN HRGENVKSAA 
NLIVEEEDLR IVEPLKDIET MEKKSVTFWC KVNRLNVTLK WTKNGEEVPF DNRVSYRVDK 
YKHMLTIKDC GFPDEGEYIV TAGQDKSVAE LLIIEAPTEF VEHLEDQTVT EFDDAVFSCQ 
LSREKANVKW YRNGREIKEG KKYKFEKDGS IHRLIIKDCR LDDECEYACG VEDRKSRARL 
FVEEIPVEII RPPQDILEAP GADVVFLAEL NKDKVEVQWL RNNMVVVQGD KHQMMSEGKI 
HRLQICDIKP RDQGEYRFIA KDKEARAKLE LAAAPKIKTA DQDLVVDVGK PLTMVVPYDA 
YPKAEAEWFK ENEPLSTKTI DTTAEQTSFR ILEAKKGDKG RYKIVLQNKH GKAEGFINLK 
VIDVPGPVRN LEVTETFDGE VSLAWEEPLT DGGSKIIGYV VERRDIKRKT WVLATDRAES 
CEFTVTGLQK GGVEYLFRVS ARNRVGTGEP VETDNPVEAR SKYDVPGPPL NVTITDVNRF 
GVSLTWEPPE YDGGAEITNY VIELRDKTSI RWDTAMTVRA EDLSATVTDV VEGQEYSFRV 
RAQNRIGVGK PSAATPFVKV ADPIERPSPP VNLTSSDQTQ SSVQLKWEPP LKDGGSPILG 
YIIERCEEGK DNWIRCNMKL VPELTYKVTG LEKGNKYLYR VSAENKAGVS DPSEILGPLT 
ADDAFVEPTM DLSAFKDGLE VIVPNPITIL VPSTGYPRPT ATWCFGDKVL ETGDRVKMKT 
LSAYAELVIS PSERSDKGIY TLKLENRVKT ISGEIDVNVI ARPSAPKELK FGDITKDSVH 
LTWEPPDDDG GSPLTGYVVE KREVSRKTWT KVMDFVTDLE FTVPDLVQGK EYLFKVCARN 
KCGPGEPAYV DEPVNMSTPA TVPDPPENVK WRDRTANSIF LTWDPPKNDG GSRIKGYIVE 
RCPRGSDKWV ACGEPVAETK MEVTGLEEGK WYAYRVKALN RQGASKPSRP TEEIQAVDTQ 
EAPEIFLDVK LLAGLTVKAG TKIELPATVT GKPEPKITWT KADMILKQDK RITIENVPKK 
STVTIVDSKR SDTGTYIIEA VNVCGRATAV VEVNVLDKPG PPAAFDITDV TNESCLLTWN 
PPRDDGGSKI TNYVVERRAT DSEVWHKLSS TVKDTNFKAT KLIPNKEYIF RVAAENMYGV 
GEPVQASPIT AKYQFDPPGP PTRLEPSDIT KDAVTLTWCE PDDDGGSPIT GYWVERLDPD 
TDKWVRCNKM PVKDTTYRVK GLTNKKKYRF RVLAENLAGP GKPSKSTEPI LIKDPIDPPW 
PPGKPTVKDV GKTSVRLNWT KPEHDGGAKI ESYVIEMLKT GTDEWVRVAE GVPTTQHLLP 
GLMEGQEYSF RVRAVNKAGE SEPSEPSDPV LCREKLYPPS PPRWLEVINI TKNTADLKWT 
VPEKDGGSPI TNYIVEKRDV RRKGWQTVDT TVKDTKCTVT PLTEGSLYVF RVAAENAIGQ 
SDYTEIEDSV LAKDTFTTPG PPYALAVVDV TKRHVDLKWE PPKNDGGRPI QRYVIEKKER 
LGTRWVKAGK TAGPDCNFRV TDVIEGTEVQ FQVRAENEAG VGHPSEPTEI LSIEDPTSPP 
SPPLDLHVTD AGRKHIAIAW KPPEKNGGSP IIGYHVEMCP VGTEKWMRVN SRPIKDLKFK 
VEEGVVPDKE YVLRVRAVNA IGVSEPSEIS ENVVAKDPDC KPTIDLETHD IIVIEGEKLS 
IPVPFRAVPV PTVSWHKDGK EVKASDRLTM KNDHISAHLE VPKSVRADAG IYTITLENKL 
GSATASINVK VIGLPGPCKD IKASDITKSS CKLTWEPPEF DGGTPILHYV LERREAGRRT 
YIPVMSGENK LSWTVKDLIP NGEYFFRVKA VNKVGGGEYI ELKNPVIAQD PKQPPDPPVD 
VEVHNPTAEA MTITWKPPLY DGGSKIMGYI IEKIAKGEER WKRCNEHLVP ILTYTAKGLE 
EGKEYQFRVR AENAAGISEP SRATPPTKAV DPIDAPKVIL RTSLEVKRGD EIALDASISG 
SPYPTITWIK DENVIVPEEI KKRAAPLVRR RKGEVQEEEP FVLPLTQRLS IDNSKKGESQ 
LRVRDSLRPD HGLYMIKVEN DHGIAKAPCT VSVLDTPGPP INFVFEDIRK TSVLCKWEPP 
LDDGGSEIIN YTLEKKDKTK PDSEWIVVTS TLRHCKYSVT KLIEGKEYLF RVRAENRFGP 
GPPCVSKPLV AKDPFGPPDA PDKPIVEDVT SNSMLVKWNE PKDNGSPILG YWLEKREVNS 
THWSRVNKSL LNALKANVDG LLEGLTYVFR VCAENAAGPG KFSPPSDPKT AHDPISPPGP 
PIPRVTDTSS TTIELEWEPP AFNGGGEIVG YFVDKQLVGT NEWSRCTEKM IKVRQYTVKE 
IREGADYKLR VSAVNAAGEG PPGETQPVTV AEPQEPPAVE LDVSVKGGIQ IMAGKTLRIP 
AVVTGRPVPT KVWTKEEGEL DKDRVVIDNV GTKSELIIKD ALRKDHGRYV ITATNSCGSK 
FAAARVEVFD VPGPVLDLKP VVTNRKMCLL NWSDPEDDGG SEITGFIIER KDAKMHTWRQ 
PIETERSKCD ITGLLEGQEY KFRVIAKNKF GCGPPVEIGP ILAVDPLGPP TSPERLTYTE 
RTKSTITLDW KEPRSNGGSP IQGYIIEKRR HDKPDFERVN KRLCPTTSFL VENLDEHQMY 
EFRVKAVNEI GESEPSLPLN VVIQDDEVPP TIKLRLSVRG DTIKVKAGEP VHIPADVTGL 
PMPKIEWSKN ETVIEKPTDA LQITKEEVSR SEAKTELSIP KAVREDKGTY TVTASNRLGS 
VFRNVHVEVY DRPSPPRNLA VTDIKAESCY LTWDAPLDNG GSEITHYVID KRDASRKKAE 
WEEVTNTAVE KRYGIWKLIP NGQYEFRVRA VNKYGISDEC KSDKVVIQDP YRLPGPPGKP 
KVLARTKGSM LVSWTPPLDN GGSPITGYWL EKREEGSPYW SRVSRAPITK VGLKGVEFNV 
PRLLEGVKYQ FRAMAINAAG IGPPSEPSDP EVAGDPIFPP GPPSCPEVKD KTKSSISLGW 
KPPAKDGGSP IKGYIVEMQE EGTTDWKRVN EPDKLITTCE CVVPNLKELR KYRFRVKAVN 
EAGESEPSDT TGEIPATDIQ EEPEVFIDIG AQDCLVCKAG SQIRIPAVIK GRPTPKSSWE 
FDGKAKKAMK DGVHDIPEDA QLETAENSSV IIIPECKRSH TGKYSITAKN KAGQKTANCR 
VKVMDVPGPP KDLKVSDITR GSCRLSWKMP DDDGGDRIKG YVIEKRTIDG KAWTKVNPDC 
GSTTFVVPDL LSEQQYFFRV RAENRFGIGP PVETIQRTTA RDPIYPPDPP IKLKIGLITK 
NTVHLSWKPP KNDGGSPVTH YIVECLAWDP TGTKKEAWRQ CNKRDVEELQ FTVEDLVEGG 
EYEFRVKAVN AAGVSKPSAT VGPVTVKDQT CPPSIDLKEF MEVEEGTNVN IVAKIKGVPF 
PTLTWFKAPP KKPDNKEPVL YDTHVNKLVV DDTCTLVIPQ SRRSDTGLYT ITAVNNLGTA 
SKEMRLNVLG RPGPPVGPIK FESVSADQMT LSWFPPKDDG GSKITNYVIE KREANRKTWV 
HVSSEPKECT YTIPKLLEGH EYVFRIMAQN KYGIGEPLDS EPETARNLFS VPGAPDKPTV 
SSVTRNSMTV NWEEPEYDGG SPVTGYWLEM KDTTSKRWKR VNRDPIKAMT LGVSYKVTGL 
IEGSDYQFRV YAINAAGVGP ASLPSDPATA RDPIAPPGPP FPKVTDWTKS SADLEWSPPL 
KDGGSKVTGY IVEYKEEGKE EWEKGKDKEV RGTKLVVTGL KEGAFYKFRV RAVNIAGIGE 
PGEVTDVIEM KDRLVSPDLQ LDASVRDRIV VHAGGVIRII AYVSGKPPPT VTWNMNERTL 
PQEATIETTA ISSSMVIKNC QRSHQGVYSL LAKNEAGERK KTIIVDVLDV PGPVGTPFLA 
HNLTNESCKL TWFSPEDDGG SPITNYVIEK RESDRRAWTP VTYTVTRQNA TVQGLIQGKA 
YFFRIAAENS IGMGPFVETS EALVIREPIT VPERPEDLEV KEVTKNTVTL TWNPPKYDGG 
SEIINYVLES RLIGTEKFHK VTNDNLLSRK YTVKGLKEGD TYEYRVSAVN IVGQGKPSFC 
TKPITCKDEL APPTLHLDFR DKLTIRVGEA FALTGRYSGK PKPKVSWFKD EADVLEDDRT 
HIKTTPATLA LEKIKAKRSD SGKYCVVVEN STGSRKGFCQ VNVVDRPGPP VGPVSFDEVT 
KDYMVISWKP PLDDGGSKIT NYIIEKKEVG KDVWMPVTSA SAKTTCKVSK LLEGKDYIFR 
IHAENLYGIS DPLVSDSMKA KDRFRVPDAP DQPIVTEVTK DSALVTWNKP HDGGKPITNY 
ILEKRETMSK RWARVTKDPI HPYTKFRVPD LLEGCQYEFR VSAENEIGIG DPSPPSKPVF 
AKDPIAKPSP PVNPEAIDTT CNSVDLTWQP PRHDGGSKIL GYIVEYQKVG DEEWRRANHT 
PESCPETKYK VTGLRDGQTY KFRVLAVNAA GESDPAHVPE PVLVKDRLEP PELILDANMA 
REQHIKVGDT LRLSAIIKGV PFPKVTWKKE DRDAPTKARI DVTPVGSKLE IRNAAHEDGG 
IYSLTVENPA GSKTVSVKVL VLDKPGPPRD LEVSEIRKDS CYLTWKEPLD DGGSVITNYV 
VERRDVASAQ WSPLSATSKK KSHFAKHLNE GNQYLFRVAA ENQYGRGPFV ETPKPIKALD 
PLHPPGPPKD LHHVDVDKTE VSLVWNKPDR DGGSPITGYL VEYQEEGTQD WIKFKTVTNL 
ECVVTGLQQG KTYRFRVKAE NIVGLGLPDT TIPIECQEKL VPPSVELDVK LIEGLVVKAG 
TTVRFPAIIR GVPVPTAKWT TDGSEIKTDE HYTVETDNFS SVLTIKNCLR RDTGEYQITV 
SNAAGSKTVA VHLTVLDVPG PPTGPINILD VTPEHMTISW QPPKDDGGSP VINYIVEKQD 
TRKDTWGVVS SGSSKTKLKI PHLQKGCEYV FRVRAENKIG VGPPLDSTPT VAKHKFSPPS 
PPGKPVVTDI TENAATVSWT LPKSDGGSPI TGYYMERREV TGKWVRVNKT PIADLKFRVT 
GLYEGNTYEF RVFAENLAGL SKPSPSSDPI KACRPIKPPG PPINPKLKDK SRETADLVWT 
KPLSDGGSPI LGYVVECQKP GTAQWNRINK DELIRQCAFR VPGLIEGNEY RFRIKAANIV 
GEGEPRELAE SVIAKDILHP PEVELDVTCR DVITVRVGQT IRILARVKGR PEPDITWTKE 
GKVLVREKRV DLIQDLPRVE LQIKEAVRAD HGKYIISAKN SSGHAQGSAI VNVLDRPGPC 
QNLKVTNVTK ENCTISWENP LDNGGSEITN FIVEYRKPNQ KGWSIVASDV TKRLIKANLL 
ANNEYYFRVC AENKVGVGPT IETKTPILAI NPIDRPGEPE NLHIADKGKT FVYLKWRRPD 
YDGGSPNLSY HVERRLKGSD DWERVHKGSI KETHYMVDRC VENQIYEFRV QTKNEGGESD 
WVKTEEVVVK EDLQKPVLDL KLSGVLTVKA GDTIRLEAGV RGKPFPEVAW TKDKDATDLT 
RSPRVKIDTR ADSSKFSLTK AKRSDGGKYV VTATNTAGSF VAYATVNVLD KPGPVRNLKI 
VDVSSDRCTV CWDPPEDDGG CEIQNYILEK CETKRMVWST YSATVLTPGT TVTRLIEGNE 
YIFRVRAENK IGTGPPTESK PVIAKTKYDK PGRPDPPEVT KVSKEEMTVV WNPPEYDGGK 
SITGYFLEKK EKHSTRWVPV NKSAIPERRM KVQNLLPDHE YQFRVKAENE IGIGEPSLPS 
RPVVAKDPIE PPGPPTNFRV VDTTKHSITL GWGKPVYDGG APIIGYVVEM RPKIADASPD 
EGWKRCNAAA QLVRKEFTVT SLDENQEYEF RVCAQNQVGI GRPAELKEAI KPKEILEPPE 
IDLDASMRKL VIVRAGCPIR LFAIVRGRPA PKVTWRKVGI DNVVRKGQVD LVDTMAFLVI 
PNSTRDDSGK YSLTLVNPAG EKAVFVNVRV LDTPGPVSDL KVSDVTKTSC HVSWAPPEND 
GGSQVTHYIV EKREADRKTW STVTPEVKKT SFHVTNLVPG NEYYFRVTAV NEYGPGVPTD 
VPKPVLASDP LSEPDPPRKL EVTEMTKNSA TLAWLPPLRD GGAKIDGYIT SYREEEQPAD 
RWTEYSVVKD LSLVVTGLKE GKKYKFRVAA RNAVGVSLPR EAEGVYEAKE QLLPPKILMP 
EQITIKAGKK LRIEAHVYGK PHPTCKWKKG EDEVVTSSHL AVHKADSSSI LIIKDVTRKD 
SGYYSLTAEN SSGTDTQKIK VVVMDAPGPP QPPFDISDID ADACSLSWHI PLEDGGSNIT 
NYIVEKCDVS RGDWVTALAS VTKTSCRVGK LIPGQEYIFR VRAENRFGIS EPLTSPKMVA 
QFPFGVPSEP KNARVTKVNK DCIFVAWDRP DSDGGSPIIG YLIERKERNS LLWVKANDTL 
VRSTEYPCAG LVEGLEYSFR IYALNKAGSS PPSKPTEYVT ARMPVDPPGK PEVIDVTKST 
VSLIWARPKH DGGSKIIGYF VEACKLPGDK WVRCNTAPHQ IPQEEYTATG LEEKAQYQFR 
AIARTAVNIS PPSEPSDPVT ILAENVPPRI DLSVAMKSLL TVKAGTNVCL DATVFGKPMP 
TVSWKKDGTL LKPAEGIKMA MQRNLCTLEL FSVNRKDSGD YTITAENSSG SKSATIKLKV 
LDKPGPPASV KINKMYSDRA MLSWEPPLED GGSEITNYIV DKRETSRPNW AQVSATVPIT 
SCSVEKLIEG HEYQFRICAE NKYGVGDPVF TEPAIAKNPY DPPGRCDPPV ISNITKDHMT 
VSWKPPADDG GSPITGYLLE KRETQAVNWT KVNRKPIIER TLKATGLQEG TEYEFRVTAI 
NKAGPGKPSD ASKAAYARDP QYPPGPPAFP KVYDTTRSSV SLSWGKPAYD GGSPIIGYLV 
EVKRADSDNW VRCNLPQNLQ KTRFEVTGLM EDTQYQFRVY AVNKIGYSDP SDVPDKHYPK 
DILIPPEGEL DADLRKTLIL RAGVTMRLYV PVKGRPPPKI TWSKPNVNLR DRIGLDIKST 
DFDTFLRCEN VNKYDAGKYI LTLENSCGKK EYTIVVKVLD TPGPPVNVTV KEISKDSAYV 
TWEPPIIDGG SPIINYVVQK RDAERKSWST VTTECSKTSF RVANLEEGKS YFFRVFAENE 
YGIGDPGETR DAVKASQTPG PVVDLKVRSV SKSSCSIGWK KPHSDGGSRI IGYVVDFLTE 
ENKWQRVMKS LSLQYSAKDL TEGKEYTFRV SAENENGEGT PSEITVVARD DVVAPDLDLK 
GLPDLCYLAK ENSNFRLKIP IKGKPAPSVS WKKGEDPLAT DTRVSVESSA VNTTLIVYDC 
QKSDAGKYTI TLKNVAGTKE GTISIKVVGK PGIPTGPIKF DEVTAEAMTL KWAPPKDDGG 
SEITNYILEK RDSVNNKWVT CASAVQKTTF RVTRLHEGME YTFRVSAENK YGVGEGLKSE 
PIVARHPFDV PDAPPPPNIV DVRHDSVSLT WTDPKKTGGS PITGYHLEFK ERNSLLWKRA 
NKTPIRMRDF KVTGLTEGLE YEFRVMAINL AGVGKPSLPS EPVVALDPID PPGKPEVINI 
TRNSVTLIWT EPKYDGGHKL TGYIVEKRDL PSKSWMKANH VNVPECAFTV TDLVEGGKYE 
FRIRAKNTAG AISAPSESTE TIICKDEYEA PTIVLDPTIK DGLTIKAGDT IVLNAISILG 
KPLPKSSWSK AGKDIRPSDI TQITSTPTSS MLTIKYATRK DAGEYTITAT NPFGTKVEHV 
KVTVLDVPGP PGPVEISNVS AEKATLTWTP PLEDGGSPIK SYILEKRETS RLLWTVVSED 
IQSCRHVATK LIQGNEYIFR VSAVNHYGKG EPVQSEPVKM VDRFGPPGPP EKPEVSNVTK 
NTATVSWKRP VDDGGSEITG YHVERREKKS LRWVRAIKTP VSDLRCKVTG LQEGSTYEFR 
VSAENRAGIG PPSEASDSVL MKDAAYPPGP PSNPHVTDTT KKSASLAWGK PHYDGGLEIT 
GYVVEHQKVG DEAWIKDTTG TALRITQFVV PDLQTKEKYN FRISAINDAG VGEPAVIPDV 
EIVEREMAPD FELDAELRRT LVVRAGLSIR IFVPIKGRPA PEVTWTKDNI NLKNRANIEN 
TESFTLLIIP ECNRYDTGKF VMTIENPAGK KSGFVNVRVL DTPGPVLNLR PTDITKDSVT 
LHWDLPLIDG GSRITNYIVE KREATRKSYS TATTKCHKCT YKVTGLSEGC EYFFRVMAEN 
EYGIGEPTET TEPVKASEAP SPPDSLNIMD ITKSTVSLAW PKPKHDGGSK ITGYVIEAQR 
KGSDQWTHIT TVKGLECVVR NLTEGEEYTF QVMAVNSAGR SAPRESRPVI VKEQTMLPEL 
DLRGIYQKLV IAKAGDNIKV EIPVLGRPKP TVTWKKGDQI LKQTQRVNFE TTATSTILNI 
NECVRSDSGP YPLTARNIVG EVGDVITIQV HDIPGPPTGP IKFDEVSSDF VTFSWDPPEN 
DGGVPISNYV VEMRQTDSTT WVELATTVIR TTYKATRLTT GLEYQFRVKA QNRYGVGPGI 
TSACIVANYP FKVPGPPGTP QVTAVTKDSM TISWHEPLSD GGSPILGYHV ERKERNGILW 
QTVSKALVPG NIFKSSGLTD GIAYEFRVIA ENMAGKSKPS KPSEPMLALD PIDPPGKPVP 
LNITRHTVTL KWAKPEYTGG FKITSYIVEK RDLPNGRWLK ANFSNILENE FTVSGLTEDA 
AYEFRVIAKN AAGAISPPSE PSDAITCRDD VEAPKIKVDV KFKDTVILKA GEAFRLEADV 
SGRPPPTMEW SKDGKELEGT AKLEIKIADF STNLVNKDST RRDSGAYTLT ATNPGGFAKH 
IFNVKVLDRP GPPEGPLAVT EVTSEKCVLS WFPPLDDGGA KIDHYIVQKR ETSRLAWTNV 
ASEVQVTKLK VTKLLKGNEY IFRVMAVNKY GVGEPLESEP VLAVNPYGPP DPPKNPEVTT 
ITKDSMVVCW GHPDSDGGSE IINYIVERRD KAGQRWIKCN KKTLTDLRYK VSGLTEGHEY 
EFRIMAENAA GISAPSPTSP FYKACDTVFK PGPPGNPRVL DTSRSSISIA WNKPIYDGGS 
EITGYMVEIA LPEEDEWQIV TPPAGLKATS YTITGLTENQ EYKIRIYAMN SEGLGEPALV 
PGTPKAEDRM LPPEIELDAD LRKVVTIRAC CTLRLFVPIK GRPAPEVKWA RDHGESLDKA 
SIESTSSYTL LIVGNVNRFD SGKYILTVEN SSGSKSAFVN VRVLDTPGPP QDLKVKEVTK 
TSVTLTWDPP LLDGGSKIKN YIVEKRESTR KAYSTVATNC HKTSWKVDQL QEGCSYYFRV 
LAENEYGIGL PAETAESVKA SERPLPPGKI TLMDVTRNSV SLSWEKPEHD GGSRILGYIV 
EMQTKGSDKW ATCATVKVTE ATITGLIQGE EYSFRVSAQN EKGISDPRQL SVPVIAKDLV 
IPPAFKLLFN TFTVLAGEDL KVDVPFIGRP TPAVTWHKDN VPLKQTTRVN AESTENNSLL 
TIKDACREDV GHYVVKLTNS AGEAIETLNV IVLDKPGPPT GPVKMDEVTA DSITLSWGPP 
KYDGGSSINN YIVEKRDTST TTWQIVSATV ARTTIKACRL KTGCEYQFRI AAENRYGKST 
YLNSEPTVAQ YPFKVPGPPG TPVVTLSSRD SMEVQWNEPI SDGGSRVIGY HLERKERNSI 
LWVKLNKTPI PQTKFKTTGL EEGVEYEFRV SAENIVGIGK PSKVSECYVA RDPCDPPGRP 
EAIIVTRNSV TLQWKKPTYD GGSKITGYIV EKKELPEGRW MKASFTNIID THFEVTGLVE 
DHRYEFRVIA RNAAGVFSEP SESTGAITAR DEVDPPRISM DPKYKDTIVV HAGESFKVDA 
DIYGKPIPTI QWIKGDQELS NTARLEIKST DFATSLSVKD AVRVDSGNYI LKAKNVAGER 
SVTVNVKVLD RPGPPEGPVV ISGVTAEKCT LAWKPPLQDG GSDIINYIVE RRETSRLVWT 
VVDANVQTLS CKVTKLLEGN EYTFRIMAVN KYGVGEPLES EPVVAKNPFV VPDAPKAPEV 
TTVTKDSMIV VWERPASDGG SEILGYVLEK RDKEGIRWTR CHKRLIGELR LRVTGLIENH 
DYEFRVSAEN AAGLSEPSPP SAYQKACDPI YKPGPPNNPK VIDITRSSVF LSWSKPIYDG 
GCEIQGYIVE KCDVSVGEWT MCTPPTGINK TNIEVEKLLE KHEYNFRICA INKAGVGEHA 
DVPGPIIVEE KLEAPDIDLD LELRKIINIR AGGSLRLFVP IKGRPTPEVK WGKVDGEIRD 
AAIIDVTSSF TSLVLDNVNR YDSGKYTLTL ENSSGTKSAF VTVRVLDTPS PPVNLKVTEI 
TKDSVSITWE PPLLDGGSKI KNYIVEKREA TRKSYAAVVT NCHKNSWKID QLQEGCSYYF 
RVTAENEYGI GLPAQTADPI KVAEVPQPPG KITVDDVTRN SVSLSWTKPE HDGGSKIIQY 
IVEMQAKHSE KWSECARVKS LQAVITNLTQ GEEYLFRVVA VNEKGRSDPR SLAVPIVAKD 
LVIEPDVKPA FSSYSVQVGQ DLKIEVPISG RPKPTITWTK DGLPLKQTTR INVTDSLDLT 
TLSIKETHKD DGGQYGITVA NVVGQKTASI EIVTLDKPDP PKGPVKFDDV SAESITLSWN 
PPLYTGGCQI TNYIVQKRDT TTTVWDVVSA TVARTTLKVT KLKTGTEYQF RIFAENRYGQ 
SFALESDPIV AQYPYKEPGP PGTPFATAIS KDSMVIQWHE PVNNGGSPVI GYHLERKERN 
SILWTKVNKT IIHDTQFKAQ NLEEGIEYEF RVYAENIVGV GKASKNSECY VARDPCDPPG 
TPEPIMVKRN EITLQWTKPV YDGGSMITGY IVEKRDLPDG RWMKASFTNV IETQFTVSGL 
TEDQRYEFRV IAKNAAGAIS KPSDSTGPIT AKDEVELPRI SMDPKFRDTI VVNAGETFRL 
EADVHGKPLP TIEWLRGDKE IEESARCEIK NTDFKALLIV KDAIRIDGGQ YILRASNVAG 
SKSFPVNVKV LDRPGPPEGP VQVTGVTSEK CSLTWSPPLQ DGGSDISHYV VEKRETSRLA 
WTVVASEVVT NSLKVTKLLE GNEYVFRIMA VNKYGVGEPL ESAPVLMKNP FVLPGPPKSL 
EVTNIAKDSM TVCWNRPDSD GGSEIIGYIV EKRDRSGIRW IKCNKRRITD LRLRVTGLTE 
DHEYEFRVSA ENAAGVGEPS PATVYYKACD PVFKPGPPTN AHIVDTTKNS ITLAWGKPIY 
DGGSEILGYV VEICKADEEE WQIVTPQTGL RVTRFEISKL TEHQEYKIRV CALNKVGLGE 
ATSVPGTVKP EDKLEAPELD LDSELRKGIV VRAGGSARIH IPFKGRPTPE ITWSREEGEF 
TDKVQIEKGV NYTQLSIDNC DRNDAGKYIL KLENSSGSKS AFVTVKVLDT PGPPQNLAVK 
EVRKDSAFLV WEPPIIDGGA KVKNYVIDKR ESTRKAYANV SSKCSKTSFK VENLTEGAIY 
YFRVMAENEF GVGVPVETVD AVKAAEPPSP PGKVTLTDVS QTSASLMWEK PEHDGGSRVL 
GYVVEMQPKG TEKWSIVAES KVCNAVVTGL SSGQEYQFRV KAYNEKGKSD PRVLGVPVIA 
KDLTIQPSLK LPFNTYSIQA GEDLKIEIPV IGRPRPNISW VKDGEPLKQT TRVNVEETAT 
STVLHIKEGN KDDFGKYTVT ATNSAGTATE NLSVIVLEKP GPPVGPVRFD EVSADFVVIS 
WEPPAYTGGC QISNYIVEKR DTTTTTWHMV SATVARTTIK ITKLKTGTEY QFRIFAENRY 
GKSAPLDSKA VIVQYPFKEP GPPGTPFVTS ISKDQMLVQW HEPVNDGGTK IIGYHLEQKE 
KNSILWVKLN KTPIQDTKFK TTGLDEGLEY EFKVSAENIV GIGKPSKVSE CFVARDPCDP 
PGRPEAIVIT RNNVTLKWKK PAYDGGSKIT GYIVEKKDLP DGRWMKASFT NVLETEFTVS 
GLVEDQRYEF RVIARNAAGN FSEPSDSSGA ITARDEIDAP NASLDPKYKD VIVVHAGETF 
VLEADIRGKP IPDVVWSKDG KELEETAARM EIKSTIQKTT LVVKDCIRTD GGQYILKLSN 
VGGTKSIPIT VKVLDRPGPP EGPLKVTGVT AEKCYLAWNP PLQDGGANIS HYIIEKRETS 
RLSWTQVSTE VQALNYKVTK LLPGNEYIFR VMAVNKYGIG EPLESGPVTA CNPYKPPGPP 
STPEVSAITK DSMVVTWARP VDDGGTEIEG YILEKRDKEG VRWTKCNKKT LTDLRLRVTG 
LTEGHSYEFR VAAENAAGVG EPSEPSVFYR ACDALYPPGP PSNPKVTDTS RSSVSLAWSK 
PIYDGGAPVK GYVVEVKEAA ADEWTTCTPP TGLQGKQFTV TKLKENTEYN FRICAINSEG 
VGEPATLPGS VVAQERIEPP EIELDADLRK VVVLRASATL RLFVTIKGRP EPEVKWEKAE 
GILTDRAQIE VTSSFTMLVI DNVTRFDSGR YNLTLENNSG SKTAFVNVRV LDSPSAPVNL 
TIREVKKDSV TLSWEPPLID GGAKITNYIV EKRETTRKAY ATITNNCTKT TFRIENLQEG 
CSYYFRVLAS NEYGIGLPAE TTEPVKVSEP PLPPGRVTLV DVTRNTATIK WEKPESDGGS 
KITGYVVEMQ TKGSEKWSTC TQVKTLEATI SGLTAGEEYV FRVAAVNEKG RSDPRQLGVP 
VIARDIEIKP SVELPFHTFN VKAREQLKID VPFKGRPQAT VNWRKDGQTL KETTRVNVSS 
SKTVTSLSIK EASKEDVGTY ELCVSNSAGS ITVPITIIVL DRPGPPGPIR IDEVSCDSIT 
ISWNPPEYDG GCQISNYIVE KKETTSTTWH IVSQAVARTS IKIVRLTTGS EYQFRVCAEN 
RYGKSSYSES SAVVAEYPFS PPGPPGTPKV VHATKSTMLV TWQVPVNDGG SRVIGYHLEY 
KERSSILWSK ANKILIADTQ MKVSGLDEGL MYEYRVYAEN IAGIGKCSKS CEPVPARDPC 
DPPGQPEVTN ITRKSVSLKW SKPHYDGGAK ITGYIVERRE LPDGRWLKCN YTNIQETYFE 
VTELTEDQRY EFRVFARNAA DSVSEPSEST GPIIVKDDVE PPRVMMDVKF RDVIVVKAGE 
VLKINADIAG RPLPVISWAK DGIEIEERAR TEIISTDNHT LLTVKDCIRR DTGQYVLTLK 
NVAGTRSVAV NCKVLDKPGP PAGPLEINGL TAEKCSLSWG RPQEDGGADI DYYIVEKRET 
SHLAWTICEG ELQMTSCKVT KLLKGNEYIF RVTGVNKYGV GEPLESVAIK ALDPFTVPSP 
PTSLEITSVT KESMTLCWSR PESDGGSEIS GYIIERREKN SLRWVRVNKK PVYDLRVKST 
GLREGCEYEY RVYAENAAGL SLPSETSPLI RAEDPVFLPS PPSKPKIVDS GKTTITIAWV 
KPLFDGGAPI TGYTVEYKKS DDTDWKTSIQ SLRGTEYTIS GLTTGAEYVF RVKSVNKVGA 
SDPSDSSDPQ IAKEREEEPL FDIDSEMRKT LIVKAGASFT MTVPFRGRPV PNVLWSKPDT 
DLRTRAYVDT TDSRTSLTIE NANRNDSGKY TLTIQNVLSA ASLTLVVKVL DTPGPPTNIT 
VQDVTKESAV LSWDVPENDG GAPVKNYHIE KREASKKAWV SVTNNCNRLS YKVTNLQEGA 
IYYFRVSGEN EFGVGIPAET KEGVKITEKP SPPEKLGVTS ISKDSVSLTW LKPEHDGGSR 
IVHYVVEALE KGQKNWVKCA VAKSTHHVVS GLRENSEYFF RVFAENQAGL SDPRELLLPV 
LIKEQLEPPE IDMKNFPSHT VYVRAGSNLK VDIPISGKPL PKVTLSRDGV PLKATMRFNT 
EITAENLTIN LKESVTADAG RYEITAANSS GTTKAFINIV VLDRPGPPTG PVVISDITEE 
SVTLKWEPPK YDGGSQVTNY ILLKRETSTA VWTEVSATVA RTMMKVMKLT TGEEYQFRIK 
AENRFGISDH IDSACVTVKL PYTTPGPPST PWVTNVTRES ITVGWHEPVS NGGSAVVGYH 
LEMKDRNSIL WQKANKLVIR TTHFKVTTIS AGLIYEFRVY AENAAGVGKP SHPSEPVLAI 
DACEPPRNVR ITDISKNSVS LSWQQPAFDG GSKITGYIVE RRDLPDGRWT KASFTNVTET 
QFIISGLTQN SQYEFRVFAR NAVGSISNPS EVVGPITCID SYGGPVIDLP LEYTEVVKYR 
AGTSVKLRAG ISGKPAPTIE WYKDDKELQT NALVCVENTT DLASILIKDA DRLNSGCYEL 
KLRNAMGSAS ATIRVQILDK PGPPGGPIEF KTVTAEKITL LWRPPADDGG AKITHYIVEK 
RETSRVVWSM VSEHLEECII TTTKIIKGNE YIFRVRAVNK YGIGEPLESD SVVAKNAFVT 
PGPPGIPEVT KITKNSMTVV WSRPIADGGS DISGYFLEKR DKKSLGWFKV LKETIRDTRQ 
KVTGLTENSD YQYRVCAVNA AGQGPFSEPS EFYKAADPID PPGPPAKIRI ADSTKSSITL 
GWSKPVYDGG SAVTGYVVEI RQGEEEEWTT VSTKGEVRTT EYVVSNLKPG VNYYFRVSAV 
NCAGQGEPIE MNEPVQAKDI LEAPEIDLDV ALRTSVIAKA GEDVQVLIPF KGRPPPTVTW 
RKDEKNLGSD ARYSIENTDS SSLLTIPQVT RNDTGKYILT IENGVGEPKS STVSVKVLDT 
PAACQKLQVK HVSRGTVTLL WDPPLIDGGS PIINYVIEKR DATKRTWSVV SHKCSSTSFK 
LIDLSEKTPF FFRVLAENEI GIGEPCETTE PVKAAEVPAP IRDLSMKDST KTSVILSWTK 
PDFDGGSVIT EYVVERKGKG EQTWSHAGIS KTCEIEVSQL KEQSVLEFRV FAKNEKGLSD 
PVTIGPITVK ELIITPEVDL SDIPGAQVTV RIGHNVHLEL PYKGKPKPSI SWLKDGLPLK 
ESEFVRFSKT ENKITLSIKN AKKEHGGKYT VILDNAVCRI AVPITVITLG PPSKPKGPIR 
FDEIKADSVI LSWDVPEDNG GGEITCYSIE KRETSQTNWK MVCSSVARTT FKVPNLVKDA 
EYQFRVRAEN RYGVSQPLVS SIIVAKHQFR IPGPPGKPVI YNVTSDGMSL TWDAPVYDGG 
SEVTGFHVEK KERNSILWQK VNTSPISGRE YRATGLVEGL DYQFRVYAEN SAGLSSPSDP 
SKFTLAVSPV DPPGTPDYID VTRETITLKW NPPLRDGGSK IVGYSIEKRQ GNERWVRCNF 
TDVSECQYTV TGLSPGDRYE FRIIARNAVG TISPPSQSSG IIMTRDENVP PIVEFGPEYF 
DGLIIKSGES LRIKALVQGR PVPRVTWFKD GVEIEKRMNM EITDVLGSTS LFVRDATRDH 
RGVYTVEAKN ASGSAKAEIK VKVQDTPGKV VGPIRFTNIT GEKMTLWWDA PLNDGCAPIT 
HYIIEKRETS RLAWALIEDK CEAQSYTAIK LINGNEYQFR VSAVNKFGVG RPLDSDPVVA 
QIQYTVPDAP GIPEPSNITG NSITLTWARP ESDGGSEIQQ YILERREKKS TRWVKVISKR 
PISETRFKVT GLTEGNEYEF HVMAENAAGV GPASGISRLI KCREPVNPPG PPTVVKVTDT 
SKTTVSLEWS KPVFDGGMEI IGYIIEMCKA DLGDWHKVNA EACVKTRYTV TDLQAGEEYK 
FRVSAINGAG KGDSCEVTGT IKAVDRLTAP ELDIDANFKQ THVVRAGASI RLFIAYQGRP 
TPTAVWSKPD SNLSLRADIH TTDSFSTLTV ENCNRNDAGK YTLTVENNSG SKSITFTVKV 
LDTPGPPGPI TFKDVTRGSA TLMWDAPLLD GGARIHHYVV EKREASRRSW QVISEKCTRQ 
IFKVNDLAEG VPYYFRVSAV NEYGVGEPYE MPEPIVATEQ PAPPRRLDVV DTSKSSAVLA 
WLKPDHDGGS RITGYLLEMR QKGSDFWVEA GHTKQLTFTV ERLVEKTEYE FRVKAKNDAG 
YSEPREAFSS VIIKEPQIEP TADLTGITNQ LITCKAGSPF TIDVPISGRP APKVTWKLEE 
MRLKETDRVS ITTTKDRTTL TVKDSMRGDS GRYFLTLENT AGVKTFSVTV VVIGRPGPVT 
GPIEVSSVSA ESCVLSWGEP KDGGGTEITN YIVEKRESGT TAWQLVNSSV KRTQIKVTHL 
TKYMEYSFRV SSENRFGVSK PLESAPIIAE HPFVPPSAPT RPEVYHVSAN AMSIRWEEPY 
HDGGSKIIGY WVEKKERNTI LWVKENKVPC LECNYKVTGL VEGLEYQFRT YALNAAGVSK 
ASEASRPIMA QNPVDAPGRP EVTDVTRSTV SLIWSAPAYD GGSKVVGYII ERKPVSEVGD 
GRWLKCNYTI VSDNFFTVTA LSEGDTYEFR VLAKNAAGVI SKGSESTGPV TCRDEYAPPK 
AELDARLHGD LVTIRAGSDL VLDAAVGGKP EPKIIWTKGD KELDLCEKVS LQYTGKRATA 
VIKFCDRSDS GKYTLTVKNA SGTKAVSVMV KVLDSPGPCG KLTVSRVTQE KCTLAWSLPQ 
EDGGAEITHY IVERRETSRL NWVIVEGECP TLSYVVTRLI KNNEYIFRVR AVNKYGPGVP 
VESEPIVARN SFTIPSPPGI PEEVGTGKEH IIIQWTKPES DGGNEISNYL VDKREKKSLR 
WTRVNKDYVV YDTRLKVTSL MEGCDYQFRV TAVNAAGNSE PSEASNFISC REPSYTPGPP 
SAPRVVDTTK HSISLAWTKP MYDGGTDIVG YVLEMQEKDT DQWYRVHTNA TIRNTEFTVP 
DLKMGQKYSF RVAAVNVKGM SEYSESIAEI EPVERIEIPD LELADDLKKT VTIRAGASLR 
LMVSVSGRPP PVITWSKQGI DLASRAIIDT TESYSLLIVD KVNRYDAGKY TIEAENQSGK 
KSATVLVKVY DTPGPCPSVK VKEVSRDSVT ITWEIPTIDG GAPVNNYIVE KREAAMRAFK 
TVTTKCSKTL YRISGLVEGT MYYFRVLPEN IYGIGEPCET SDAVLVSEVP LVPAKLEVVD 
VTKSTVTLAW EKPLYDGGSR LTGYVLEACK AGTERWMKVV TLKPTVLEHT VTSLNEGEQY 
LFRIRAQNEK GVSEPRETVT AVTVQDLRVL PTIDLSTMPQ KTIHVPAGRP VELVIPIAGR 
PPPAASWFFA GSKLRESERV TVETHTKVAK LTIRETTIRD TGEYTLELKN VTGTTSETIK 
VIILDKPGPP TGPIKIDEID ATSITISWEP PELDGGAPLS GYVVEQRDAH RPGWLPVSES 
VTRSTFKFTR LTEGNEYVFR VAATNRFGIG SYLQSEVIEC RSSIRIPGPP ETLQIFDVSR 
DGMTLTWYPP EDDGGSQVTG YIVERKEVRA DRWVRVNKVP VTMTRYRSTG LTEGLEYEHR 
VTAINARGSG KPSRPSKPIV AMDPIAPPGK PQNPRVTDTT RTSVSLAWSV PEDEGGSKVT 
GYLIEMQKVD QHEWTKCNTT PTKIREYTLT HLPQGAEYRF RVLACNAGGP GEPAEVPGTV 
KVTEMLEYPD YELDERYQEG IFVRQGGVIR LTIPIKGKPF PICKWTKEGQ DISKRAMIAT 
SETHTELVIK EADRGDSGTY DLVLENKCGK KAVYIKVRVI GSPNSPEGPL EYDDIQVRSV 
RVSWRPPADD GGADILGYIL ERREVPKAAW YTIDSRVRGT SLVVKGLKEN VEYHFRVSAE 
NQFGISKPLK SEEPVTPKTP LNPPEPPSNP PEVLDVTKSS VSLSWSRPKD DGGSRVTGYY 
IERKETSTDK WVRHNKTQIT TTMYTVTGLV PDAEYQFRII AQNDVGLSET SPASEPVVCK 
DPFDKPSQPG ELEILSISKD SVTLQWEKPE CDGGKEILGY WVEYRQSGDS AWKKSNKERI 
KDKQFTIGGL LEATEYEFRV FAENETGLSR PRRTAMSIKT KLTSGEAPGI RKEMKDVTTK 
LGEAAQLSCQ IVGRPLPDIK WYRFGKELIQ SRKYKMSSDG RTHTLTVMTE EQEDEGVYTC 
IATNEVGEVE TSSKLLLQAT PQFHPGYPLK EKYYGAVGST LRLHVMYIGR PVPAMTWFHG 
QKLLQNSENI TIENTEHYTH LVMKNVQRKT HAGKYKVQLS NVFGTVDAIL DVEIQDKPDK 
PTGPIVIEAL LKNSAVISWK PPADDGGSWI TNYVVEKCEA KEGAEWQLVS SAISVTTCRI 
VNLTENAGYY FRVSAQNTFG ISDPLEVSSV VIIKSPFEKP GAPGKPTITA VTKDSCVVAW 
KPPASDGGAK IRNYYLEKRE KKQNKWISVT TEEIRETVFS VKNLIEGLEY EFRVKCENLG 
GESEWSEISE PITPKSDVPI QAPHFKEELR NLNVRYQSNA TLVCKVTGHP KPIVKWYRQG 
KEIIADGLKY RIQEFKGGYH QLIIASVTDD DATVYQVRAT NQGGSVSGTA SLEVEVPAKI 
HLPKTLEGMG AVHALRGEVV SIKIPFSGKP DPVITWQKGQ DLIDNNGHYQ VIVTRSFTSL 
VFPNGVERKD AGFYVVCAKN RFGIDQKTVE LDVADVPDPP RGVKVSDVSR DSVNLTWTEP 
ASDGGSKITN YIVEKCATTA ERWLRVGQAR ETRYTVINLF GKTSYQFRVI AENKFGLSKP 
SEPSEPTITK EDKTRAMNYD EEVDETREVS MTKASHSSTK ELYEKYMIAE DLGRGEFGIV 
HRCVETSSKK TYMAKFVKVK GTDQVLVKKE ISILNIARHR NILHLHESFE SMEELVMIFE 
FISGLDIFER INTSAFELNE REIVSYVHQV CEALQFLHSH NIGHFDIRPE NIIYQTRRSS 
TIKIIEFGQA RQLKPGDNFR LLFTAPEYYA PEVHQHDVVS TATDMWSLGT LVYVLLSGIN 
PFLAETNQQI IENIMNAEYT FDEEAFKEIS IEAMDFVDRL LVKERKSRMT ASEALQHPWL 
KQKIERVSTK VIRTLKHRRY YHTLIKKDLN MVVSAARISC GGAIRSQKGV SVAKVKVASI 
EIGPVSGQIM HAVGEEGGHV KYVCKIENYD QSTQVTWYFG VRQLENSEKY EITYEDGVAI 
LYVKDITKLD DGTYRCKVVN DYGEDSSYAE LFVKGVREVY DYYCRRTMKK IKRRTDTMRL 
LERPPEFTLP LYNKTAYVGE NVRFGVTITV HPEPHVTWYK SGQKIKPGDN DKKYTFESDK 
GLYQLTINSV TTDDDAEYTV VARNKYGEDS CKAKLTVTLH PPPTDSTLRP MFKRLLANAE 
CQEGQSVCFE IRVSGIPPPT LKWEKDGQPL SLGPNIEIIH EGLDYYALHI RDTLPEDTGY 
YRVTATNTAG STSCQAHLQV ERLRYKKQEF KSKEEHERHV QKQIDKTLRM AEILSGTESV 
PLTQVAKEAL REAAVLYKPA VSTKTVKGEF RLEIEEKKEE RKLRMPYDVP EPRKYKQTTI 
EEDQRIKQFV PMSDMKWYKK IRDQYEMPGK LDRVVQKRPK RIRLSRWEQF YVMPLPRITD 
QYRPKWRIPK LSQDDLEIVR PARRRTPSPD YDFYYRPRRR SLGDISDEEL LLPIDDYLAM 
KRTEEERLRL EEELELGFSA SPPSRSPPHF ELSSLRYSSP QAHVKVEETR KDFRYSTYHI 
PTKAEASTSY AELRERHAQA AYRQPKQRQR IMAEREDEEL LRPVTTTQHL SEYKSELDFM 
SKEEKSRKKS RRQREVTEIT EIEEEYEISK HAQRESSSSA SRLLRRRRSL SPTYIELMRP 
VSELIRSRPQ PAEEYEDDTE RRSPTPERTR PRSPSPVSSE RSLSRFERSA RFDIFSRYES 
MKAALKTQKT SERKYEVLSQ QPFTLDHAPR ITLRMRSHRV PCGQNTRFIL NVQSKPTAEV 
KWYHNGVELQ ESSKIHYTNT SGVLTLEILD CHTDDSGTYR AVCTNYKGEA SDYATLDVTG 
GDYTTYASQR RDEEVPRSVF PELTRTEAYA VSSFKKTSEM EASSSVREVK SQMTETRESL 
SSYEHSASAE MKSAALEEKS LEEKSTTRKI KTTLAARILT KPRSMTVYEG ESARFSCDTD 
GEPVPTVTWL RKGQVLSTSA RHQVTTTKYK STFEISSVQA SDEGNYSVVV ENSEGKQEAE 
FTLTIQKARV TEKAVTSPPR VKSPEPRVKS PEAVKSPKRV KSPEPSHPKA VSPTETKPTP 
TEKVQHLPVS APPKITQFLK AEASKEIAKL TCVVESSVLR AKEVTWYKDG KKLKENGHFQ 
FHYSADGTYE LKINNLTESD QGEYVCEISG EGGTSKTNLQ FMGQAFKSIH EKVSKISETK 
KSDQKTTEST VTRKTEPKAP EPISSKPVIV TGLQDTTVSS DSVAKFAVKA TGEPRPTAIW 
TKDGKAITQG GKYKLSEDKG GFFLEIHKTD TSDSGLYTCT VKNSAGSVSS SCKLTIKAIK 
DTEAQKVSTQ KTSEITPQKK AVVQEEISQK ALRSEEIKMS EAKSQEKLAL KEEASKVLIS 
EEVKKSAATS LEKSIVHEEI TKTSQASEEV RTHAEIKAFS TQMSINEGQR LVLKANIAGA 
TDVKWVLNGV ELTNSEEYRY GVSGSDQTLT IKQASHRDEG ILTCISKTKE GIVKCQYDLT 
LSKELSDAPA FISQPRSQNI NEGQNVLFTC EISGEPSPEI EWFKNNLPIS ISSNVSISRS 
RNVYSLEIRN ASVSDSGKYT IKAKNFRGQC SATASLMVLP LVEEPSREVV LRTSGDTSLQ 
GSFSSQSVQM SASKQEASFS SFSSSSASSM TEMKFASMSA QSMSSMQESF VEMSSSSFMG 
ISNMTQLESS TSKMLKAGIR GIPPKIEALP SDISIDEGKV LTVACAFTGE PTPEVTWSCG 
GRKIHSQEQG RFHIENTDDL TTLIIMDVQK QDGGLYTLSL GNEFGSDSAT VNIHIRSI

Genular Protein ID: 2796055235

Symbol: Q7Z3B7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7Z3B7

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Gene3D 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 1263
  • Mass: 142281
  • Checksum: A80DADEDB1D87D2E
  • Sequence:
    • TRPPTRPYGC EKTTEGQAEG KERHVSEKSK LHQAEGTVYP FVDDFSDVTI KKEIRNNFGK 
LGRSEKENVQ ECAQSDYLPN IHSERISDSY NTKDSSAIVY EESLGEEIHY PGKKVKHRII 
EFEKLHVEKG VLEKRPTRTS IVNPPQKKID DKAFSLKQRE SRSSNLNANM YQAEKMSPNT 
ESDSSNIAIN LKLLSSQTHK EFDAQEREQQ EKISLIDKPA ISKRAEHESP ITFDLKQLHT 
QIKHTDVKFQ ELDSGQPEEA YFKIQHPADT ENIVFDLKQM YSHIGDPALE FQGQETREQQ 
EIHYKEKIPS PETLQPDTHN ISKSVQNNVF ASQEISSSQE LSNRTMVEKS SIDENSISLE 
KEVRHVQEQN LDILKTDLSL KSFSEEIYSE SCALLPTSSA DIEETGLSEK SCPLENGGRS 
SISHLKKAAS EEKPLGVGEM EEECTLEPEL AAFPKQDGGT QECTDATLED HRGDVQEADT 
LHRQLSLSQC FPLLMTEEQQ NPGEQISTNI HASGEEKCYE EVQVQNEASF STLEGEMIET 
SFSQNIPKLD EAHTTEAAES ETSLTQYLLA AGKREVPETK DTRDQAKLVQ SESITSMEVE 
EVTFNTVYEY YNQKQESLGR PLSPESDISI GVGSTTSEEI SELDQFYTPP SSVEYFESPK 
SPDLYFNPSD ITKQSSIHSG GETVERYSTP LGEVAERYST PSEGEVGERY STPPGETLER 
YSTPPGETLE RYSTPPGETL ERYSTPPGET LERYSTPPGE TLERYSTPPG EALERYSIPT 
GGPNPTGTFK TYPSKIERED GTPNEHFYTP TEERGSAYEI WRSDSFGTPN EAIEPKDNEM 
PPSFIEPLTK RKVYENTTLG FIVEVEGLPV PGVKWYRNKS LLEPDERIKM ERVGNVCSLE 
ISNIQKGEGG EYMCHAVNII GEAKSFANVD IMPQEERVVA LPPPVTHQHV MEFDLEHTTS 
SRTPSPQEIV LEVELSEKDV KEFEKQVKIV TVPEFTPDHK SMIVSLDVLP FNFVDPNMDS 
REGEDKELKI DLEVFEMPPR FIMPICDFKI PENSDAVFKC SVIGIPTPEV KWYKEYMCIE 
PDNIKYVISE EKGSYTLKIR NVCLSDSATY RCRAVNCVGE AICRGFLTMG DSEIFAVIAK 
KSKVTLSSLM EELVLKSNYT DSFFEFQVVE GPPRFIKGIS DCYAPIGTAA YFQCLVRGSP 
RPTVYWYKDG KLVQGRRFTV EESGTGFHNL FITSLVKSDE GEYRCVATNK SGMAESFAAL 
TLT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.