Details for: SLA

Gene ID: 6503

Symbol: SLA

Ensembl ID: ENSG00000155926

Description: Src like adaptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 128.5157
    Cell Significance Index: -19.9900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 59.0790
    Cell Significance Index: -14.9900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 56.4667
    Cell Significance Index: -22.9400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 46.3077
    Cell Significance Index: -23.8200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.2942
    Cell Significance Index: -20.0900
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 7.5927
    Cell Significance Index: 20.3400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.1855
    Cell Significance Index: -22.0700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.7786
    Cell Significance Index: -15.4800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.5829
    Cell Significance Index: -10.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.6622
    Cell Significance Index: 85.2700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.6183
    Cell Significance Index: 35.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3193
    Cell Significance Index: 59.8000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.1746
    Cell Significance Index: 21.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0044
    Cell Significance Index: 191.1500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8003
    Cell Significance Index: 79.1700
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.7914
    Cell Significance Index: 7.0300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6602
    Cell Significance Index: 19.3900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6435
    Cell Significance Index: 581.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5365
    Cell Significance Index: 34.6200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4407
    Cell Significance Index: 9.6500
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.4378
    Cell Significance Index: 4.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4012
    Cell Significance Index: 26.9800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3787
    Cell Significance Index: 61.5900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.3232
    Cell Significance Index: 68.0700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2222
    Cell Significance Index: 24.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.1797
    Cell Significance Index: 133.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0996
    Cell Significance Index: 11.6100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0376
    Cell Significance Index: 23.4800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0360
    Cell Significance Index: 2.4900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0239
    Cell Significance Index: 0.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0167
    Cell Significance Index: 3.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0091
    Cell Significance Index: 0.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0029
    Cell Significance Index: 1.0400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0015
    Cell Significance Index: 0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0007
    Cell Significance Index: 1.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0004
    Cell Significance Index: -0.2000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0097
    Cell Significance Index: -0.2800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0099
    Cell Significance Index: -18.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0117
    Cell Significance Index: -18.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0169
    Cell Significance Index: -23.0300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0188
    Cell Significance Index: -0.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0241
    Cell Significance Index: -18.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0248
    Cell Significance Index: -4.2300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0253
    Cell Significance Index: -17.4900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0318
    Cell Significance Index: -23.3100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0323
    Cell Significance Index: -20.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0368
    Cell Significance Index: -7.3000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0388
    Cell Significance Index: -0.5900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0393
    Cell Significance Index: -21.4700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0434
    Cell Significance Index: -19.6800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0446
    Cell Significance Index: -8.0400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0478
    Cell Significance Index: -21.1300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0544
    Cell Significance Index: -15.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0626
    Cell Significance Index: -6.3900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0643
    Cell Significance Index: -0.9400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0788
    Cell Significance Index: -11.4600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0867
    Cell Significance Index: -10.2300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1075
    Cell Significance Index: -6.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1129
    Cell Significance Index: -13.8800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1435
    Cell Significance Index: -19.7100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1514
    Cell Significance Index: -3.1400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1552
    Cell Significance Index: -9.3200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1660
    Cell Significance Index: -18.9500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1728
    Cell Significance Index: -3.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1780
    Cell Significance Index: -23.0000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1901
    Cell Significance Index: -21.7800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1908
    Cell Significance Index: -19.8700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2027
    Cell Significance Index: -25.9900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2196
    Cell Significance Index: -3.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2364
    Cell Significance Index: -11.1100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2413
    Cell Significance Index: -18.5200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2572
    Cell Significance Index: -6.5700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3040
    Cell Significance Index: -21.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3090
    Cell Significance Index: -23.0300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3300
    Cell Significance Index: -14.3500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3577
    Cell Significance Index: -5.3900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3583
    Cell Significance Index: -22.5800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.3672
    Cell Significance Index: -6.3300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3780
    Cell Significance Index: -16.7200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3887
    Cell Significance Index: -3.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3907
    Cell Significance Index: -10.9200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3940
    Cell Significance Index: -22.1100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4141
    Cell Significance Index: -15.6800
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.4176
    Cell Significance Index: -4.3300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.4181
    Cell Significance Index: -2.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4224
    Cell Significance Index: -21.9400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4272
    Cell Significance Index: -19.9200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4295
    Cell Significance Index: -22.5500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4383
    Cell Significance Index: -22.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4423
    Cell Significance Index: -11.3700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4683
    Cell Significance Index: -13.3700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.4997
    Cell Significance Index: -9.7700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5058
    Cell Significance Index: -16.5600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5234
    Cell Significance Index: -16.6700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.5234
    Cell Significance Index: -7.5000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5612
    Cell Significance Index: -19.6600
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.5630
    Cell Significance Index: -4.9600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.6080
    Cell Significance Index: -8.0800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6137
    Cell Significance Index: -22.5300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.6268
    Cell Significance Index: -9.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Src-like adaptor protein**: SLA is a member of the Src-like adaptor protein family, characterized by its ability to bind to phosphotyrosine residues and interact with various signaling proteins. 2. **Significant expression in immune cells**: SLA is expressed in a diverse range of immune cells, including decidual natural killer cells, mature T cells, and innate lymphoid cells, highlighting its importance in both innate and adaptive immunity. 3. **Involvement in multiple signaling pathways**: SLA is implicated in various signaling pathways, including the cop9 signalosome, cytokine signaling, and the regulation of the MAPK cascade, underscoring its central role in immune regulation. 4. **Regulation of immune responses**: SLA's expression is associated with the regulation of immune responses, including the modulation of cytokine production and the control of cell proliferation. **Pathways and Functions:** 1. **Cytokine signaling in the immune system**: SLA is involved in the regulation of cytokine signaling, which is crucial for the coordination of immune responses. 2. **Regulation of the MAPK cascade**: SLA's interaction with MAPK proteins modulates the activation of the MAPK cascade, a key signaling pathway involved in immune cell function. 3. **Endosomal trafficking**: SLA is localized to the endosome, where it regulates the trafficking of immune-related proteins, influencing immune cell function. 4. **Regulation of flt3 signaling**: SLA negatively regulates flt3 signaling, which is critical for the development and function of hematopoietic cells. **Clinical Significance:** 1. **Innate immunity**: SLA's expression in decidual natural killer cells highlights its importance in innate immunity, particularly in the context of pregnancy and immune tolerance. 2. **Adaptive immunity**: SLA's involvement in the regulation of T cell function underscores its role in adaptive immunity, where it modulates cytokine production and cell proliferation. 3. **Cancer immunology**: SLA's expression in certain cancer-associated immune cells, such as memory T cells, suggests its potential as a therapeutic target in cancer immunotherapy. 4. **Immunodeficiency disorders**: SLA's involvement in the regulation of immune responses implies its potential role in the pathogenesis of immunodeficiency disorders, where immune cell function is compromised. In conclusion, SLA is a multifaceted protein that plays a crucial role in regulating immune responses, particularly in the context of innate and adaptive immunity. Its involvement in multiple signaling pathways, including cytokine signaling and the regulation of the MAPK cascade, underscores its importance in immune regulation. Further research is necessary to elucidate the specific mechanisms by which SLA modulates immune responses and to explore its potential therapeutic applications in the context of immune-related disorders.

Genular Protein ID: 4027469456

Symbol: SLAP1_HUMAN

Name: Src-like-adapter

UniProtKB Accession Codes:

Q13239 B7Z4J2 B7Z4L6 Q6FI01 Q9UMQ8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 6 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8825655

Title: Chromosomal localization of the mouse Src-like adapter protein (Slap) gene and its putative human homolog SLA.

PubMed ID: 8825655

DOI: 10.1006/geno.1995.1289

PubMed ID: 9020066

Title: Expression of Src-like adapter protein mRNA is induced by all-trans retinoic acid.

PubMed ID: 9020066

DOI: 10.1006/bbrc.1996.5887

PubMed ID: 9660183

Title: The gene for the human Src-like adaptor protein (hSLAP) is located within the 64-kb intron of the thyroglobulin gene.

PubMed ID: 9660183

DOI: 10.1046/j.1432-1327.1998.2540297.x

PubMed ID: 11696592

Title: Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling.

PubMed ID: 11696592

DOI: 10.1084/jem.194.9.1263

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11179692

Title: Characterization of promoter region and genomic structure of the murine and human genes encoding Src like adapter protein.

PubMed ID: 11179692

DOI: 10.1016/s0378-1119(00)00516-3

PubMed ID: 10449770

Title: SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling.

PubMed ID: 10449770

DOI: 10.1073/pnas.96.17.9775

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 276
  • Mass: 31156
  • Checksum: B0FCC7D7B2ECA378
  • Sequence:
    • MGNSMKSTPA PAERPLPNPE GLDSDFLAVL SDYPSPDISP PIFRRGEKLR VISDEGGWWK 
AISLSTGRES YIPGICVARV YHGWLFEGLG RDKAEELLQL PDTKVGSFMI RESETKKGFY 
SLSVRHRQVK HYRIFRLPNN WYYISPRLTF QCLEDLVNHY SEVADGLCCV LTTPCLTQST 
AAPAVRASSS PVTLRQKTVD WRRVSRLQED PEGTENPLGV DESLFSYGLR ESIASYLSLT 
SEDNTSFDRK KKSISLMYGG SKRKSSFFSS PPYFED

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.