SLA | ENSG00000155926 | NCBI 6503

Details for: SLA

Gene ID: 6503

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: SLA

Ensembl ID: ENSG00000155926

Description: Src like adaptor

Cell Significance Landscape

Display Count:

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Flt3 signaling
(R-HSA-9607240)
Immune system
(R-HSA-168256)
Negative regulation of flt3
(R-HSA-9706369)
Cop9 signalosome
(GO:0008180)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endosome
(GO:0005768)
Epidermal growth factor receptor binding
(GO:0005154)
Nucleoplasm
(GO:0005654)
Phosphotyrosine residue binding
(GO:0001784)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Regulation of mapk cascade
(GO:0043408)
Signal transduction
(GO:0007165)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

CD4-positive helper T cell CL0000492

CSI 29.75

rCSI 22.5%

PRS 67.99
group 3 innate lymphoid cell CL0001071

CSI 22.98

rCSI 17.27%

PRS 59.1
alpha-beta T cell CL0000789

CSI 13.02

rCSI 15.26%

PRS 70.58
Langerhans cell CL0000453

CSI 12.28

rCSI 18.76%

PRS 71.02
precursor B cell CL0000817

CSI 11.67

rCSI 10.22%

PRS 64.53
Kupffer cell CL0000091

CSI 11.61

rCSI 26.56%

PRS 53.81
central nervous system macrophage CL0000878

CSI 11.56

rCSI 38.32%

PRS 56.41
double negative thymocyte CL0002489

CSI 10.42

rCSI 7.25%

PRS 64.67
Hofbauer cell CL3000001

CSI 8.72

rCSI 16.46%

PRS 64.74
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 8.54

rCSI 17.02%

PRS 72.62
alternatively activated macrophage CL0000890

CSI 8.5

rCSI 10.69%

PRS 67.09
intermediate monocyte CL0002393

CSI 8.19

rCSI 12.36%

PRS 57.45
helper T cell CL0000912

CSI 6.61

rCSI 9.35%

PRS 60.94
mature T cell CL0002419

CSI 6.6

rCSI 5.14%

PRS 72.19
megakaryocyte-erythroid progenitor cell CL0000050

CSI 6.27

rCSI 5.66%

PRS 51.16
hematopoietic stem cell CL0000037

CSI 6.27

rCSI 4.16%

PRS 57.94
CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human CL0001074

CSI 6.2

rCSI 72.02%

PRS 83.67
myeloid dendritic cell CL0000782

CSI 6.04

rCSI 8.76%

PRS 70.38
activated type II NK T cell CL0000931

CSI 6.01

rCSI 6.76%

PRS 70.8
CD4-positive, alpha-beta thymocyte CL0000810

CSI 5.8

rCSI 4.64%

PRS 75.55
forebrain radial glial cell CL0013000

CSI 5.76

rCSI 18.47%

PRS 60.58
microglial cell CL0000129

CSI 5.71

rCSI 22.99%

PRS 60.97
thymocyte CL0000893

CSI 5.46

rCSI 19.39%

PRS 86.43
CD1c-positive myeloid dendritic cell CL0002399

CSI 5.06

rCSI 6.11%

PRS 62.73
glutamatergic neuron CL0000679

CSI 4.67

rCSI 9.6%

PRS 45.98
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 4.49

rCSI 3.37%

PRS 83.1
natural T-regulatory cell CL0000903

CSI 4.46

rCSI 8.45%

PRS 85.13
naive T cell CL0000898

CSI 4.44

rCSI 3.09%

PRS 68.61
CD14-positive monocyte CL0001054

CSI 4.15

rCSI 5.17%

PRS 65.15
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 4.1

rCSI 2.76%

PRS 66.69
erythrocyte CL0000232

CSI 4.02

rCSI 9.13%

PRS 59.48
neuroblast (sensu Vertebrata) CL0000031

CSI 3.87

rCSI 4.96%

PRS 52
granulocyte CL0000094

CSI 3.85

rCSI 5.88%

PRS 63.77
colon macrophage CL0009038

CSI 3.49

rCSI 16.13%

PRS 74.51
cerebral cortex GABAergic interneuron CL0010011

CSI 3.45

rCSI 10.19%

PRS 57.98
CD4-positive, alpha-beta memory T cell CL0000897

CSI 3.43

rCSI 2.46%

PRS 68.3
early lymphoid progenitor CL0000936

CSI 3.41

rCSI 2.99%

PRS 59.63
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 3.28

rCSI 3.91%

PRS 74.33
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 3.26

rCSI 2.17%

PRS 76.63
hematopoietic precursor cell CL0008001

CSI 3.24

rCSI 3.34%

PRS 72.21
myeloid leukocyte CL0000766

CSI 3.23

rCSI 2.98%

PRS 55.51
mononuclear phagocyte CL0000113

CSI 3.08

rCSI 6.78%

PRS 58.18
monocyte CL0000576

CSI 2.99

rCSI 5.41%

PRS 71.56
elicited macrophage CL0000861

CSI 2.97

rCSI 2.72%

PRS 62.71
effector CD8-positive, alpha-beta T cell CL0001050

CSI 2.9

rCSI 2.2%

PRS 66.95
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 2.86

rCSI 1.69%

PRS 71.13
common dendritic progenitor CL0001029

CSI 2.83

rCSI 3.55%

PRS 64.73
neural cell CL0002319

CSI 2.72

rCSI 10.27%

PRS 42.64
activated CD4-positive, alpha-beta T cell CL0000896

CSI 2.67

rCSI 2.47%

PRS 74.47
CD8-positive, alpha-beta thymocyte CL0000811

CSI 2.62

rCSI 4.08%

PRS 79.81
regulatory T cell CL0000815

CSI 2.58

rCSI 2.99%

PRS 68.9
CD8-positive, alpha-beta memory T cell CL0000909

CSI 2.56

rCSI 2.67%

PRS 79.08
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 2.44

rCSI 2.22%

PRS 68.66
double-positive, alpha-beta thymocyte CL0000809

CSI 2.41

rCSI 2.45%

PRS 67.93
lung interstitial macrophage CL4033043

CSI 2.3

rCSI 5.15%

PRS 72.79
CD14-low, CD16-positive monocyte CL0002396

CSI 2.21

rCSI 1.7%

PRS 54.01
effector CD4-positive, alpha-beta T cell CL0001044

CSI 2.18

rCSI 6.24%

PRS 73.71
CD14-positive, CD16-positive monocyte CL0002397

CSI 2.17

rCSI 2.85%

PRS 67.82
myeloid lineage restricted progenitor cell CL0000839

CSI 2.16

rCSI 11.15%

PRS 77.33
activated CD8-positive, alpha-beta T cell CL0000906

CSI 2.15

rCSI 2.11%

PRS 77.92
inflammatory macrophage CL0000863

CSI 2.11

rCSI 3.6%

PRS 79.16
macrophage CL0000235

CSI 1.97

rCSI 3.58%

PRS 76.45
basophil CL0000767

CSI 1.92

rCSI 4.06%

PRS 73.21
T follicular helper cell CL0002038

CSI 1.89

rCSI 1.42%

PRS 69.58
granulocyte monocyte progenitor cell CL0000557

CSI 1.86

rCSI 1.61%

PRS 59.03
mature alpha-beta T cell CL0000791

CSI 1.85

rCSI 6.71%

PRS 74.13
tissue-resident macrophage CL0000864

CSI 1.84

rCSI 8.61%

PRS 70.89
lung macrophage CL1001603

CSI 1.83

rCSI 4.08%

PRS 61.72
common lymphoid progenitor CL0000051

CSI 1.78

rCSI 2.38%

PRS 76.73
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 1.75

rCSI 2.4%

PRS 74.53
lung resident memory CD8-positive, alpha-beta T cell CL4033039

CSI 1.75

rCSI 4.52%

PRS 81.81
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 1.71

rCSI 1.68%

PRS 70.15
kidney interstitial alternatively activated macrophage CL1000695

CSI 1.71

rCSI 4.46%

PRS 53.58
neutrophil CL0000775

CSI 1.68

rCSI 9.41%

PRS 63
myelocyte CL0002193

CSI 1.62

rCSI 10.64%

PRS 82.99
T-helper 1 cell CL0000545

CSI 1.61

rCSI 2.9%

PRS 78.07
lymphoid lineage restricted progenitor cell CL0000838

CSI 1.57

rCSI 6.1%

PRS 74.97
exhausted T cell CL0011025

CSI 1.57

rCSI 26.49%

PRS 80
alveolar macrophage CL0000583

CSI 1.54

rCSI 2.54%

PRS 59.65
common myeloid progenitor CL0000049

CSI 1.52

rCSI 1.23%

PRS 55.53
metallothionein-positive alveolar macrophage CL4033042

CSI 1.41

rCSI 15.3%

PRS 79.05
fraction A pre-pro B cell CL0002045

CSI 1.4

rCSI 1.6%

PRS 75.38
T-helper 17 cell CL0000899

CSI 1.29

rCSI 1.02%

PRS 76.39
innate lymphoid cell CL0001065

CSI 1.2

rCSI 2.48%

PRS 57.56
renal interstitial pericyte CL1001318

CSI 1.15

rCSI 3.18%

PRS 50.21
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 1.1

rCSI 1.94%

PRS 36.04
dendritic cell, human CL0001056

CSI 1.08

rCSI 1.66%

PRS 62.66
mature B cell CL0000785

CSI 1.05

rCSI 0.91%

PRS 65
promonocyte CL0000559

CSI 1.05

rCSI 1.79%

PRS 63.82
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 1.03

rCSI 1.77%

PRS 73.52
promyelocyte CL0000836

CSI 0.97

rCSI 1.4%

PRS 64.11
memory T cell CL0000813

CSI 0.82

rCSI 1.58%

PRS 81.76
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 0.79

rCSI 0.96%

PRS 44.55
hematopoietic multipotent progenitor cell CL0000837

CSI 0.72

rCSI 1.73%

PRS 73.03
CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell CL0000915

CSI 0.67

rCSI 3.04%

PRS 84.41
immature innate lymphoid cell CL0001082

CSI 0.63

rCSI 19.57%

PRS 92.46
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 0.52

rCSI 3.16%

PRS 75.62
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 0.42

rCSI 2.11%

PRS 66.68
progenitor cell CL0011026

CSI 0.4

rCSI 0.86%

PRS 55.61
cytotoxic T cell CL0000910

CSI 0.23

rCSI 1.34%

PRS 64.89

megakaryocyte progenitor cell CL0000553

CSI 0.2

rCSI 3.9%

PRS 85.5%
cytotoxic T cell CL0000910

CSI 0.2

rCSI 1.3%

PRS 64.9%
progenitor cell CL0011026

CSI 0.4

rCSI 0.9%

PRS 55.6%
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 0.4

rCSI 2.1%

PRS 66.7%
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 0.5

rCSI 3.2%

PRS 75.6%
immature innate lymphoid cell CL0001082

CSI 0.6

rCSI 19.6%

PRS 92.5%
CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell CL0000915

CSI 0.7

rCSI 3.0%

PRS 84.4%
hematopoietic multipotent progenitor cell CL0000837

CSI 0.7

rCSI 1.7%

PRS 73.0%
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 0.8

rCSI 1.0%

PRS 44.6%
memory T cell CL0000813

CSI 0.8

rCSI 1.6%

PRS 81.8%
promyelocyte CL0000836

CSI 1.0

rCSI 1.4%

PRS 64.1%
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 1.0

rCSI 1.8%

PRS 73.5%
promonocyte CL0000559

CSI 1.1

rCSI 1.8%

PRS 63.8%
mature B cell CL0000785

CSI 1.1

rCSI 0.9%

PRS 65.0%
dendritic cell, human CL0001056

CSI 1.1

rCSI 1.7%

PRS 62.7%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 1.1

rCSI 1.9%

PRS 36.0%
renal interstitial pericyte CL1001318

CSI 1.2

rCSI 3.2%

PRS 50.2%
innate lymphoid cell CL0001065

CSI 1.2

rCSI 2.5%

PRS 57.6%
T-helper 17 cell CL0000899

CSI 1.3

rCSI 1.0%

PRS 76.4%
fraction A pre-pro B cell CL0002045

CSI 1.4

rCSI 1.6%

PRS 75.4%
metallothionein-positive alveolar macrophage CL4033042

CSI 1.4

rCSI 15.3%

PRS 79.1%
common myeloid progenitor CL0000049

CSI 1.5

rCSI 1.2%

PRS 55.5%
alveolar macrophage CL0000583

CSI 1.5

rCSI 2.5%

PRS 59.7%
exhausted T cell CL0011025

CSI 1.6

rCSI 26.5%

PRS 80.0%
lymphoid lineage restricted progenitor cell CL0000838

CSI 1.6

rCSI 6.1%

PRS 75.0%
T-helper 1 cell CL0000545

CSI 1.6

rCSI 2.9%

PRS 78.1%
myelocyte CL0002193

CSI 1.6

rCSI 10.6%

PRS 83.0%
neutrophil CL0000775

CSI 1.7

rCSI 9.4%

PRS 63.0%
kidney interstitial alternatively activated macrophage CL1000695

CSI 1.7

rCSI 4.5%

PRS 53.6%
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 1.7

rCSI 1.7%

PRS 70.2%
lung resident memory CD8-positive, alpha-beta T cell CL4033039

CSI 1.8

rCSI 4.5%

PRS 81.8%
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 1.8

rCSI 2.4%

PRS 74.5%
common lymphoid progenitor CL0000051

CSI 1.8

rCSI 2.4%

PRS 76.7%
lung macrophage CL1001603

CSI 1.8

rCSI 4.1%

PRS 61.7%
tissue-resident macrophage CL0000864

CSI 1.8

rCSI 8.6%

PRS 70.9%
mature alpha-beta T cell CL0000791

CSI 1.9

rCSI 6.7%

PRS 74.1%
granulocyte monocyte progenitor cell CL0000557

CSI 1.9

rCSI 1.6%

PRS 59.0%
T follicular helper cell CL0002038

CSI 1.9

rCSI 1.4%

PRS 69.6%
basophil CL0000767

CSI 1.9

rCSI 4.1%

PRS 73.2%
macrophage CL0000235

CSI 2.0

rCSI 3.6%

PRS 76.5%
inflammatory macrophage CL0000863

CSI 2.1

rCSI 3.6%

PRS 79.2%
activated CD8-positive, alpha-beta T cell CL0000906

CSI 2.2

rCSI 2.1%

PRS 77.9%
myeloid lineage restricted progenitor cell CL0000839

CSI 2.2

rCSI 11.2%

PRS 77.3%
CD14-positive, CD16-positive monocyte CL0002397

CSI 2.2

rCSI 2.9%

PRS 67.8%
effector CD4-positive, alpha-beta T cell CL0001044

CSI 2.2

rCSI 6.2%

PRS 73.7%
CD14-low, CD16-positive monocyte CL0002396

CSI 2.2

rCSI 1.7%

PRS 54.0%
lung interstitial macrophage CL4033043

CSI 2.3

rCSI 5.2%

PRS 72.8%
double-positive, alpha-beta thymocyte CL0000809

CSI 2.4

rCSI 2.5%

PRS 67.9%
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 2.4

rCSI 2.2%

PRS 68.7%
CD8-positive, alpha-beta memory T cell CL0000909

CSI 2.6

rCSI 2.7%

PRS 79.1%
regulatory T cell CL0000815

CSI 2.6

rCSI 3.0%

PRS 68.9%
CD8-positive, alpha-beta thymocyte CL0000811

CSI 2.6

rCSI 4.1%

PRS 79.8%
activated CD4-positive, alpha-beta T cell CL0000896

CSI 2.7

rCSI 2.5%

PRS 74.5%
neural cell CL0002319

CSI 2.7

rCSI 10.3%

PRS 42.6%
common dendritic progenitor CL0001029

CSI 2.8

rCSI 3.6%

PRS 64.7%
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 2.9

rCSI 1.7%

PRS 71.1%
effector CD8-positive, alpha-beta T cell CL0001050

CSI 2.9

rCSI 2.2%

PRS 67.0%
elicited macrophage CL0000861

CSI 3.0

rCSI 2.7%

PRS 62.7%
monocyte CL0000576

CSI 3.0

rCSI 5.4%

PRS 71.6%
mononuclear phagocyte CL0000113

CSI 3.1

rCSI 6.8%

PRS 58.2%
myeloid leukocyte CL0000766

CSI 3.2

rCSI 3.0%

PRS 55.5%
hematopoietic precursor cell CL0008001

CSI 3.2

rCSI 3.3%

PRS 72.2%
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 3.3

rCSI 2.2%

PRS 76.6%
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 3.3

rCSI 3.9%

PRS 74.3%
early lymphoid progenitor CL0000936

CSI 3.4

rCSI 3.0%

PRS 59.6%
CD4-positive, alpha-beta memory T cell CL0000897

CSI 3.4

rCSI 2.5%

PRS 68.3%
cerebral cortex GABAergic interneuron CL0010011

CSI 3.5

rCSI 10.2%

PRS 58.0%
colon macrophage CL0009038

CSI 3.5

rCSI 16.1%

PRS 74.5%
granulocyte CL0000094

CSI 3.9

rCSI 5.9%

PRS 63.8%
neuroblast (sensu Vertebrata) CL0000031

CSI 3.9

rCSI 5.0%

PRS 52.0%
erythrocyte CL0000232

CSI 4.0

rCSI 9.1%

PRS 59.5%
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 4.1

rCSI 2.8%

PRS 66.7%
CD14-positive monocyte CL0001054

CSI 4.2

rCSI 5.2%

PRS 65.2%
naive T cell CL0000898

CSI 4.4

rCSI 3.1%

PRS 68.6%
natural T-regulatory cell CL0000903

CSI 4.5

rCSI 8.5%

PRS 85.1%
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 4.5

rCSI 3.4%

PRS 83.1%
glutamatergic neuron CL0000679

CSI 4.7

rCSI 9.6%

PRS 46.0%
CD1c-positive myeloid dendritic cell CL0002399

CSI 5.1

rCSI 6.1%

PRS 62.7%
thymocyte CL0000893

CSI 5.5

rCSI 19.4%

PRS 86.4%
microglial cell CL0000129

CSI 5.7

rCSI 23.0%

PRS 61.0%
forebrain radial glial cell CL0013000

CSI 5.8

rCSI 18.5%

PRS 60.6%
CD4-positive, alpha-beta thymocyte CL0000810

CSI 5.8

rCSI 4.6%

PRS 75.6%
activated type II NK T cell CL0000931

CSI 6.0

rCSI 6.8%

PRS 70.8%
myeloid dendritic cell CL0000782

CSI 6.0

rCSI 8.8%

PRS 70.4%
CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human CL0001074

CSI 6.2

rCSI 72.0%

PRS 83.7%
hematopoietic stem cell CL0000037

CSI 6.3

rCSI 4.2%

PRS 57.9%
megakaryocyte-erythroid progenitor cell CL0000050

CSI 6.3

rCSI 5.7%

PRS 51.2%
mature T cell CL0002419

CSI 6.6

rCSI 5.1%

PRS 72.2%
helper T cell CL0000912

CSI 6.6

rCSI 9.4%

PRS 60.9%
intermediate monocyte CL0002393

CSI 8.2

rCSI 12.4%

PRS 57.5%
alternatively activated macrophage CL0000890

CSI 8.5

rCSI 10.7%

PRS 67.1%
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 8.5

rCSI 17.0%

PRS 72.6%
Hofbauer cell CL3000001

CSI 8.7

rCSI 16.5%

PRS 64.7%
double negative thymocyte CL0002489

CSI 10.4

rCSI 7.3%

PRS 64.7%
central nervous system macrophage CL0000878

CSI 11.6

rCSI 38.3%

PRS 56.4%
Kupffer cell CL0000091

CSI 11.6

rCSI 26.6%

PRS 53.8%
precursor B cell CL0000817

CSI 11.7

rCSI 10.2%

PRS 64.5%
Langerhans cell CL0000453

CSI 12.3

rCSI 18.8%

PRS 71.0%
alpha-beta T cell CL0000789

CSI 13.0

rCSI 15.3%

PRS 70.6%
group 3 innate lymphoid cell CL0001071

CSI 23.0

rCSI 17.3%

PRS 59.1%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

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Baseline Cell Context(s): Comma-separated if multiple.

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Target Cell Context(s): Comma-separated if multiple.

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Node Size: Proportional to Target Cell CSI magnitude
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [SLA](/details-gene/6503), or Src like adaptor, is a protein-coding gene located on chromosome 8q24.22. As its name suggests, it functions as an adaptor protein in intracellular signaling cascades, particularly those involving tyrosine kinases. It plays a role in regulating the MAPK cascade and is implicated in cytokine signaling within the immune system. Expression data indicates that [SLA](/details-gene/6503) is a significant component of hematopoietic cells, showing prominent expression in various T cell subsets, including `[CD4-positive helper T cell](/details-cell/CL0000492)`, as well as in innate lymphoid cells and myeloid lineage cells such as macrophages and Langerhans cells. This expression pattern, combined with its known molecular functions in signal transduction and phosphotyrosine binding, positions [SLA](/details-gene/6503) as a key modulator of immune cell activation and response. ## Cellular Roles and Expression Landscape The expression profile of [SLA](/details-gene/6503) firmly establishes its importance within the hematopoietic system. **Overall**, its most significant expression is observed in lymphoid lineages. It is a top marker in `[CD4-positive helper T cell](/details-cell/CL0000492)` (CSI: 29.75), `[group 3 innate lymphoid cell](/details-cell/CL0001071)` (CSI: 22.98), and `[alpha-beta T cell](/details-cell/CL0000789)` (CSI: 13.02), highlighting a crucial role in the adaptive immune system. Its involvement in T cell biology is further supported by one study demonstrating its functional role in T cell receptor signaling ([Link](https://doi.org/10.1073/pnas.96.17.9775)). Beyond the adaptive lymphocyte compartment, [SLA](/details-gene/6503) also displays high significance in the myeloid lineage. It is highly expressed in professional antigen-presenting cells like `[Langerhans cell](/details-cell/CL0000453)` (CSI: 12.28) and various tissue-resident macrophage populations, including `[Kupffer cell](/details-cell/CL0000091)` (CSI: 11.61) and `[central nervous system macrophage](/details-cell/CL0000878)` (CSI: 11.56). This broad expression across both lymphoid and myeloid cells suggests that [SLA](/details-gene/6503) is a fundamental component of signaling pathways common to many types of immune responses. Furthermore, its expression in progenitor cells, such as `[megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050)`, is consistent with its annotated role in regulating Flt3 signaling, a key pathway in hematopoiesis. ## Pathways and Molecular Function Functionally, [SLA](/details-gene/6503) operates as an intracellular adaptor protein, facilitating signal transduction. Its molecular functions include `[Phosphotyrosine residue binding](https://www.ebi.ac.uk/QuickGO/term/GO:0001784)` and general `[Protein binding](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)`, which are characteristic of adaptor proteins that assemble larger signaling complexes. Through these interactions, it participates in the `[Regulation of mapk cascade](https://www.ebi.ac.uk/QuickGO/term/GO:0043408)`, a central pathway controlling cell proliferation, differentiation, and survival. The gene's involvement in broader biological systems is highlighted by its association with Reactome pathways. Its role in the `[Immune system](https://reactome.org/content/detail/R-HSA-168256)` and `[Cytokine signaling in immune system](https://reactome.org/content/detail/R-HSA-1280215)` is entirely consistent with its high expression in lymphocytes and macrophages. Furthermore, its specific annotation in `[Flt3 signaling](https://reactome.org/content/detail/R-HSA-9607240)` and, notably, the `[Negative regulation of flt3](https://reactome.org/content/detail/R-HSA-9706369)` pathway, suggests it can act as a molecular brake to fine-tune signaling output from this critical hematopoietic receptor tyrosine kinase. Cellular component annotations place the protein in multiple subcellular locations, including the `[Cytoplasm](https://www.ebi.ac.uk/QuickGO/term/GO:0005737)`, `[Plasma membrane](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)`, and `[Endosome](https://www.ebi.ac.uk/QuickGO/term/GO:0005768)`, reflecting the dynamic nature of signal transduction events. ## Research Directions The widespread and significant expression of [SLA](/details-gene/6503) across diverse immune cell types, coupled with its role as a signaling adaptor, suggests it is a central hub for regulating immune responses. Future research should focus on dissecting its specific, context-dependent functions in different cell lineages. Based on the available data, several testable hypotheses can be proposed: 1. Given its high significance in `[CD4-positive helper T cell](/details-cell/CL0000492)` and its role in T cell receptor signaling ([Link](https://doi.org/10.1073/pnas.96.17.9775)), [SLA](/details-gene/6503) likely plays a critical role in modulating the strength or duration of TCR signaling to direct the differentiation of naive T cells into specific helper subsets (e.g., Th1, Th2, Th17). 2. The high expression of [SLA](/details-gene/6503) in multiple macrophage populations (`[Kupffer cell](/details-cell/CL0000091)`, `[alternatively activated macrophage](/details-cell/CL0000890)`) and its link to the `[Negative regulation of flt3](https://reactome.org/content/detail/R-HSA-9706369)` pathway suggest that [SLA](/details-gene/6503) may function to dampen pro-inflammatory kinase signaling in macrophages, thereby contributing to the resolution of inflammation or the maintenance of a tissue-resident homeostatic state. A key experiment to test the first hypothesis would involve the use of CRISPR-Cas9 to knock out [SLA](/details-gene/6503) in primary human naive CD4+ T cells. These engineered cells, alongside wild-type controls, would then be cultured under polarizing conditions for Th1, Th2, and Th17 lineages. The impact of [SLA](/details-gene/6503) deletion on T cell differentiation would be assessed by measuring the expression of lineage-defining transcription factors (e.g., T-bet, GATA3, RORγt) by flow cytometry and quantifying the production of signature cytokines (e.g., IFN-γ, IL-4, IL-17) using ELISA or multiplex bead assays. As a therapeutic target, [SLA](/details-gene/6503) presents both opportunities and challenges. Being an intracellular adaptor protein, it is not readily targetable by antibodies, making small molecule inhibitors the more likely therapeutic modality. In autoimmune diseases characterized by T cell hyperactivity, a drug that enhances the negative regulatory functions of [SLA](/details-gene/6503) could be beneficial. Conversely, in oncology, inhibiting its potential suppressive roles might enhance anti-tumor immunity. However, its broad expression across many essential immune cells indicates a high risk of on-target, off-tissue side effects, which would require careful consideration in any therapeutic development program.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Src-like-adapter

Genular Protein ID: 4027469456

Symbol: SLAP1_HUMAN

Name: Src-like-adapter

UniProtKB Accession Codes:

Q13239 B7Z4J2 B7Z4L6 Q6FI01 Q9UMQ8

Database IDs:

Citations:

PubMed ID: 8825655

Title: Chromosomal localization of the mouse Src-like adapter protein (Slap) gene and its putative human homolog SLA.

PubMed ID: 8825655

DOI: 10.1006/geno.1995.1289

PubMed ID: 9020066

Title: Expression of Src-like adapter protein mRNA is induced by all-trans retinoic acid.

PubMed ID: 9020066

DOI: 10.1006/bbrc.1996.5887

PubMed ID: 9660183

Title: The gene for the human Src-like adaptor protein (hSLAP) is located within the 64-kb intron of the thyroglobulin gene.

PubMed ID: 9660183

DOI: 10.1046/j.1432-1327.1998.2540297.x

PubMed ID: 11696592

Title: Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling.

PubMed ID: 11696592

DOI: 10.1084/jem.194.9.1263

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11179692

Title: Characterization of promoter region and genomic structure of the murine and human genes encoding Src like adapter protein.

PubMed ID: 11179692

DOI: 10.1016/s0378-1119(00)00516-3

PubMed ID: 10449770

Title: SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling.

PubMed ID: 10449770

DOI: 10.1073/pnas.96.17.9775

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

Length: 276
Mass: 31156
Checksum: B0FCC7D7B2ECA378
Sequence:

MGNSMKSTPA PAERPLPNPE GLDSDFLAVL SDYPSPDISP PIFRRGEKLR VISDEGGWWK 
AISLSTGRES YIPGICVARV YHGWLFEGLG RDKAEELLQL PDTKVGSFMI RESETKKGFY 
SLSVRHRQVK HYRIFRLPNN WYYISPRLTF QCLEDLVNHY SEVADGLCCV LTTPCLTQST 
AAPAVRASSS PVTLRQKTVD WRRVSRLQED PEGTENPLGV DESLFSYGLR ESIASYLSLT 
SEDNTSFDRK KKSISLMYGG SKRKSSFFSS PPYFED

Details for: SLA

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Chromosomal localization of the mouse Src-like adapter protein (Slap) gene and its putative human homolog SLA. PubMed ID: 8825655

Expression of Src-like adapter protein mRNA is induced by all-trans retinoic acid. PubMed ID: 9020066

The gene for the human Src-like adaptor protein (hSLAP) is located within the 64-kb intron of the thyroglobulin gene. PubMed ID: 9660183

Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling. PubMed ID: 11696592

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence and analysis of human chromosome 8. PubMed ID: 16421571

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of promoter region and genomic structure of the murine and human genes encoding Src like adapter protein. PubMed ID: 11179692

SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling. PubMed ID: 10449770

Phosphoproteome of resting human platelets. PubMed ID: 18088087

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569