Details for: HMGN2

Gene ID: 3151

Symbol: HMGN2

Ensembl ID: ENSG00000198830

Description: high mobility group nucleosomal binding domain 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.31
    Marker Score: 56792
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.7
    Marker Score: 2649
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.62
    Marker Score: 23537
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.59
    Marker Score: 35539
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.54
    Marker Score: 3160
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.51
    Marker Score: 40746
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 3.49
    Marker Score: 2123
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.47
    Marker Score: 4190
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 3.43
    Marker Score: 1265
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 3.38
    Marker Score: 45448
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.35
    Marker Score: 9567
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.3
    Marker Score: 9107.5
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 3.25
    Marker Score: 171808
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.21
    Marker Score: 3432
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.21
    Marker Score: 179359.5
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.18
    Marker Score: 3002
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 3.16
    Marker Score: 6631
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.14
    Marker Score: 9919
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.13
    Marker Score: 13414.5
  • Cell Name: centroblast (CL0009112)
    Fold Change: 3.12
    Marker Score: 1535
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 3.08
    Marker Score: 1934
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 3.08
    Marker Score: 5045
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 3.07
    Marker Score: 4348.5
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.02
    Marker Score: 8958.5
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.02
    Marker Score: 2970
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 3.01
    Marker Score: 17872
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3
    Marker Score: 987
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.94
    Marker Score: 1013
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.92
    Marker Score: 2821.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.91
    Marker Score: 25319.5
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.9
    Marker Score: 4470.5
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.88
    Marker Score: 5610
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.85
    Marker Score: 10970
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 2.84
    Marker Score: 1879
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.84
    Marker Score: 4510
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.83
    Marker Score: 21066
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.82
    Marker Score: 2653
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 2.82
    Marker Score: 2515
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.79
    Marker Score: 3287
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.78
    Marker Score: 2102
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.77
    Marker Score: 5790
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.77
    Marker Score: 11348
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.76
    Marker Score: 1427
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.75
    Marker Score: 4790
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.75
    Marker Score: 7477
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.72
    Marker Score: 92562
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 2.7
    Marker Score: 629
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.69
    Marker Score: 1962
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.69
    Marker Score: 1016
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.68
    Marker Score: 6538.5
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.67
    Marker Score: 68342
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.65
    Marker Score: 1195
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.65
    Marker Score: 17251
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.64
    Marker Score: 26595
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.64
    Marker Score: 5364
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.64
    Marker Score: 2817
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.63
    Marker Score: 629
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.63
    Marker Score: 2954
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.62
    Marker Score: 1744
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.62
    Marker Score: 6174.5
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.62
    Marker Score: 7654
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 2.62
    Marker Score: 2174
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.61
    Marker Score: 1066
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.61
    Marker Score: 777
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.61
    Marker Score: 1547
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.6
    Marker Score: 969
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.58
    Marker Score: 1871.5
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.58
    Marker Score: 11117
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.58
    Marker Score: 2864.5
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 2.57
    Marker Score: 623.5
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.57
    Marker Score: 6726
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.56
    Marker Score: 1489
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.56
    Marker Score: 19966
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.55
    Marker Score: 3669
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.55
    Marker Score: 16316.5
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 2.55
    Marker Score: 4371
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.54
    Marker Score: 7122
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.54
    Marker Score: 3738
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.54
    Marker Score: 6399
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 2.53
    Marker Score: 877.5
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.53
    Marker Score: 9803
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.53
    Marker Score: 25650.5
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.53
    Marker Score: 1455
  • Cell Name: PP cell (CL0000696)
    Fold Change: 2.52
    Marker Score: 568
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.52
    Marker Score: 4930
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.51
    Marker Score: 86963
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.51
    Marker Score: 2510
  • Cell Name: basophil (CL0000767)
    Fold Change: 2.5
    Marker Score: 1186
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.49
    Marker Score: 1663.5
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.48
    Marker Score: 876
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.47
    Marker Score: 5614
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 2.47
    Marker Score: 1784
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.46
    Marker Score: 790
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.46
    Marker Score: 1481.5
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.45
    Marker Score: 1609
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.43
    Marker Score: 2159
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 2.42
    Marker Score: 846
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.42
    Marker Score: 1756.5
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.42
    Marker Score: 3890.5
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 2.41
    Marker Score: 1194

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Other Information

**Key characteristics:** * HMGN2 is a large protein with a molecular weight of approximately 170 kDa. * It is a nuclear protein that is found in the nucleus of cells. * It is involved in the regulation of the innate immune response. **Pathways and functions:** * HMGN2 is involved in the activation of antimicrobial peptides. * It is a key regulator of the innate immune response to bacterial infection. * It is expressed in a variety of cell types, including mesodermal cells, theca cells, interstitial cells of the ovary, mature T cells, extravillous trophoblast, blood cells, germinal center B cells, glycinergic neurons, radial glial cells, and malignant cells. * HMGN2 is involved in the regulation of inflammation by binding to chromatin and regulating the expression of inflammatory genes. * It is also involved in the regulation of cell migration and differentiation. **Clinical significance:** HMGN2 is a potential therapeutic target for the treatment of inflammatory diseases. It can inhibit the activity of antimicrobial peptides and promote inflammation. This could lead to the development of new treatments for inflammatory diseases such as sepsis and rheumatoid arthritis.

Genular Protein ID: 2950708452

Symbol: HMGN2_HUMAN

Name: Non-histone chromosomal protein HMG-17

UniProtKB Accession Codes:

P05204 Q0VGD5 Q6FGI5 Q96C64

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 EPD 1 Ensembl 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3754870

Title: Chromosomal protein HMG-17. Complete human cDNA sequence and evidence for a multigene family.

PubMed ID: 3754870

DOI: 10.1016/s0021-9258(17)38417-x

PubMed ID: 2565024

Title: Human non-histone chromosomal protein HMG-17: identification, characterization, chromosome localization and RFLPs of a functional gene from the large multigene family.

PubMed ID: 2565024

DOI: 10.1093/nar/17.6.2301

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2040281

Title: Comparison of multiple forms of the high mobility group I proteins in rodent and human cells. Identification of the human high mobility group I-C protein.

PubMed ID: 2040281

DOI: 10.1111/j.1432-1033.1991.tb16003.x

PubMed ID: 10739259

Title: Phosphorylation and subcellular redistribution of high mobility group proteins 14 and 17, analyzed by mass spectrometry.

PubMed ID: 10739259

DOI: 10.1110/ps.9.1.170

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 28190768

Title: Serine ADP-ribosylation depends on HPF1.

PubMed ID: 28190768

DOI: 10.1016/j.molcel.2017.01.003

Sequence Information:

  • Length: 90
  • Mass: 9393
  • Checksum: B1C58E52200422C8
  • Sequence:
    • MPKRKAEGDA KGDKAKVKDE PQRRSARLSA KPAPPKPEPK PKKAPAKKGE KVPKGKKGKA 
DAGKEGNNPA ENGDAKTDQA QKAEGAGDAK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.