Details for: HMGN2

Gene ID: 3151

Symbol: HMGN2

Ensembl ID: ENSG00000198830

Description: high mobility group nucleosomal binding domain 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 306.9847
    Cell Significance Index: -47.7500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 290.0529
    Cell Significance Index: -73.5700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 263.5287
    Cell Significance Index: -108.5600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 228.6906
    Cell Significance Index: -107.9700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 212.9532
    Cell Significance Index: -109.5400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 162.0066
    Cell Significance Index: -108.7100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 76.0368
    Cell Significance Index: -93.7500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 27.2500
    Cell Significance Index: -107.5300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 24.7082
    Cell Significance Index: -75.8900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.0411
    Cell Significance Index: -59.0500
  • Cell Name: theca cell (CL0000503)
    Fold Change: 14.4953
    Cell Significance Index: 85.1600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.3504
    Cell Significance Index: -27.0300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 11.3589
    Cell Significance Index: 145.4700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 10.5202
    Cell Significance Index: 281.4100
  • Cell Name: centroblast (CL0009112)
    Fold Change: 8.4888
    Cell Significance Index: 19.8100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 8.4829
    Cell Significance Index: 67.7300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 8.4139
    Cell Significance Index: 91.4700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 8.1417
    Cell Significance Index: 282.9200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 7.8709
    Cell Significance Index: 164.7500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 7.2082
    Cell Significance Index: 850.0700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 6.3415
    Cell Significance Index: 166.7500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 5.4503
    Cell Significance Index: 42.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 5.0554
    Cell Significance Index: 265.4300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.9307
    Cell Significance Index: 115.4400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.2656
    Cell Significance Index: 75.4500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.0973
    Cell Significance Index: 199.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.0846
    Cell Significance Index: 229.8900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.0667
    Cell Significance Index: 56.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.0594
    Cell Significance Index: 420.1400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.9865
    Cell Significance Index: 81.2900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.9009
    Cell Significance Index: 371.8800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.8870
    Cell Significance Index: 204.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.8594
    Cell Significance Index: 1264.2300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.7417
    Cell Significance Index: 29.1300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.6264
    Cell Significance Index: 322.9400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.4544
    Cell Significance Index: 1340.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.3822
    Cell Significance Index: 111.9600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.1538
    Cell Significance Index: 388.2600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.0343
    Cell Significance Index: 23.1100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.6978
    Cell Significance Index: 219.3400
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.6891
    Cell Significance Index: 8.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.6286
    Cell Significance Index: 75.9400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.5928
    Cell Significance Index: 100.3900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.5628
    Cell Significance Index: 41.7300
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.4903
    Cell Significance Index: 9.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.1215
    Cell Significance Index: 62.9300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.9415
    Cell Significance Index: 26.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9388
    Cell Significance Index: 186.3100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6665
    Cell Significance Index: 108.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5425
    Cell Significance Index: 15.1600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5099
    Cell Significance Index: 23.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5041
    Cell Significance Index: 86.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4628
    Cell Significance Index: 88.0800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3740
    Cell Significance Index: 37.0000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.3049
    Cell Significance Index: 2.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2911
    Cell Significance Index: 15.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2824
    Cell Significance Index: 56.6400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2495
    Cell Significance Index: 89.5000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.2402
    Cell Significance Index: 4.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2125
    Cell Significance Index: 160.8300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1358
    Cell Significance Index: 4.3500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.0666
    Cell Significance Index: 0.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0457
    Cell Significance Index: 33.4900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0051
    Cell Significance Index: -9.6300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0121
    Cell Significance Index: -22.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0172
    Cell Significance Index: -1.7600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0179
    Cell Significance Index: -27.5800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0252
    Cell Significance Index: -18.6400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0325
    Cell Significance Index: -44.2000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0554
    Cell Significance Index: -38.3300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0795
    Cell Significance Index: -49.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0893
    Cell Significance Index: -50.3600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0939
    Cell Significance Index: -1.6600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1251
    Cell Significance Index: -79.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1399
    Cell Significance Index: -40.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1514
    Cell Significance Index: -31.8800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1747
    Cell Significance Index: -79.2700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2869
    Cell Significance Index: -7.3300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2872
    Cell Significance Index: -19.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3120
    Cell Significance Index: -8.9900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3944
    Cell Significance Index: -13.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4232
    Cell Significance Index: -49.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4302
    Cell Significance Index: -26.4400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4790
    Cell Significance Index: -5.7100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5260
    Cell Significance Index: -60.2600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5884
    Cell Significance Index: -85.5300
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.6271
    Cell Significance Index: -3.3000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.7050
    Cell Significance Index: -80.4800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7611
    Cell Significance Index: -60.2800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.9910
    Cell Significance Index: -107.7900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.9999
    Cell Significance Index: -104.1100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.0831
    Cell Significance Index: -83.1200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.2292
    Cell Significance Index: -82.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.2562
    Cell Significance Index: -26.7500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.4551
    Cell Significance Index: -13.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.6215
    Cell Significance Index: -35.1300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.7472
    Cell Significance Index: -26.1800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.7548
    Cell Significance Index: -14.7400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.7617
    Cell Significance Index: -108.0100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.9170
    Cell Significance Index: -56.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HMGN2 is a member of the high mobility group (HMG) protein family, which is characterized by its ability to bind to DNA and alter chromatin structure. This protein is specifically involved in nucleosomal DNA binding, chromatin organization, and protein binding. HMGN2 is highly expressed in various cell types, including mesodermal cells, theca cells, and mature T cells, suggesting its involvement in multiple cellular processes. **Pathways and Functions:** HMGN2 is implicated in several key pathways, including: 1. **Antimicrobial Humoral Immune Response Mediated by Antimicrobial Peptide:** HMGN2 has been shown to interact with antimicrobial peptides, which are crucial for the innate immune response against pathogens. 2. **Chromatin Organization:** HMGN2 plays a role in chromatin organization, influencing gene expression and transcriptional regulation. 3. **Chromatin Binding:** HMGN2 binds to chromatin, modulating the structure and function of chromatin. 4. **Nucleosomal DNA Binding:** HMGN2 specifically binds to nucleosomal DNA, influencing chromatin dynamics and transcriptional regulation. 5. **Protein Binding:** HMGN2 interacts with various proteins, including histones, transcription factors, and other chromatin-associated proteins. **Clinical Significance:** HMGN2 has been implicated in several human diseases, including: 1. **Autoimmune Disorders:** HMGN2 has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus, where its dysregulation can contribute to immune system dysfunction. 2. **Cancer:** HMGN2 has been found to be overexpressed in various types of cancer, including breast, lung, and colon cancer, suggesting its potential as a diagnostic or therapeutic target. 3. **Neurological Disorders:** HMGN2 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where its dysregulation can contribute to neuronal dysfunction. In conclusion, HMGN2 is a multifaceted protein with far-reaching implications in immune response, chromatin organization, and cell regulation. Its dysregulation can contribute to various human diseases, highlighting the need for further research into the mechanisms underlying HMGN2's functions and its potential as a therapeutic target.

Genular Protein ID: 2950708452

Symbol: HMGN2_HUMAN

Name: Non-histone chromosomal protein HMG-17

UniProtKB Accession Codes:

P05204 Q0VGD5 Q6FGI5 Q96C64

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 Ensembl 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3754870

Title: Chromosomal protein HMG-17. Complete human cDNA sequence and evidence for a multigene family.

PubMed ID: 3754870

DOI: 10.1016/s0021-9258(17)38417-x

PubMed ID: 2565024

Title: Human non-histone chromosomal protein HMG-17: identification, characterization, chromosome localization and RFLPs of a functional gene from the large multigene family.

PubMed ID: 2565024

DOI: 10.1093/nar/17.6.2301

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2040281

Title: Comparison of multiple forms of the high mobility group I proteins in rodent and human cells. Identification of the human high mobility group I-C protein.

PubMed ID: 2040281

DOI: 10.1111/j.1432-1033.1991.tb16003.x

PubMed ID: 10739259

Title: Phosphorylation and subcellular redistribution of high mobility group proteins 14 and 17, analyzed by mass spectrometry.

PubMed ID: 10739259

DOI: 10.1110/ps.9.1.170

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 28190768

Title: Serine ADP-ribosylation depends on HPF1.

PubMed ID: 28190768

DOI: 10.1016/j.molcel.2017.01.003

Sequence Information:

  • Length: 90
  • Mass: 9393
  • Checksum: B1C58E52200422C8
  • Sequence:
    • MPKRKAEGDA KGDKAKVKDE PQRRSARLSA KPAPPKPEPK PKKAPAKKGE KVPKGKKGKA 
DAGKEGNNPA ENGDAKTDQA QKAEGAGDAK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.