Details for: RNASE1

Gene ID: 6035

Symbol: RNASE1

Ensembl ID: ENSG00000129538

Description: ribonuclease A family member 1, pancreatic

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 300.7485
    Cell Significance Index: -46.7800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 190.2868
    Cell Significance Index: -48.2700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 141.5957
    Cell Significance Index: -58.3300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 105.5981
    Cell Significance Index: -42.9000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 72.1586
    Cell Significance Index: -48.4200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 45.4049
    Cell Significance Index: -43.3500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 38.7605
    Cell Significance Index: -47.7900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.5041
    Cell Significance Index: -49.5700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 16.3141
    Cell Significance Index: 849.7800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 16.2659
    Cell Significance Index: -49.9600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.2173
    Cell Significance Index: -48.2100
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 11.7146
    Cell Significance Index: 43.6600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 11.7013
    Cell Significance Index: 149.8600
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 9.3709
    Cell Significance Index: 24.7200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 7.3903
    Cell Significance Index: 170.7400
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 6.5687
    Cell Significance Index: 32.7700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 6.2860
    Cell Significance Index: 88.1700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 6.0812
    Cell Significance Index: 69.0900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 4.5532
    Cell Significance Index: 80.4600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 4.1166
    Cell Significance Index: 702.9400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.9230
    Cell Significance Index: 23.8400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.0603
    Cell Significance Index: 224.1000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.8596
    Cell Significance Index: 1679.1100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.7516
    Cell Significance Index: 27.1000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.6372
    Cell Significance Index: 43.0500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.5098
    Cell Significance Index: 90.6400
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.2678
    Cell Significance Index: 7.4900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.1129
    Cell Significance Index: 27.8200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 1.0549
    Cell Significance Index: 798.4700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7100
    Cell Significance Index: 70.2300
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.6748
    Cell Significance Index: 4.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6627
    Cell Significance Index: 361.9300
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.3787
    Cell Significance Index: 2.7200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2134
    Cell Significance Index: 40.6200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2045
    Cell Significance Index: 26.2100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1622
    Cell Significance Index: 0.9800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1408
    Cell Significance Index: 6.3800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0480
    Cell Significance Index: 5.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0143
    Cell Significance Index: 2.8400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0136
    Cell Significance Index: 1.3900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0088
    Cell Significance Index: 5.5200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0209
    Cell Significance Index: -0.6700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0250
    Cell Significance Index: -47.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0377
    Cell Significance Index: -27.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0488
    Cell Significance Index: -7.9400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0554
    Cell Significance Index: -31.2500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0636
    Cell Significance Index: -46.6500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0706
    Cell Significance Index: -44.8700
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -0.0762
    Cell Significance Index: -0.2700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0985
    Cell Significance Index: -11.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1121
    Cell Significance Index: -50.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1213
    Cell Significance Index: -43.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1228
    Cell Significance Index: -22.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1434
    Cell Significance Index: -41.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1527
    Cell Significance Index: -30.6400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1614
    Cell Significance Index: -4.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1747
    Cell Significance Index: -3.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1887
    Cell Significance Index: -39.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2130
    Cell Significance Index: -29.2500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2173
    Cell Significance Index: -15.0300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2201
    Cell Significance Index: -27.0600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2631
    Cell Significance Index: -33.9900
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.2708
    Cell Significance Index: -2.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2970
    Cell Significance Index: -43.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2987
    Cell Significance Index: -34.2200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3013
    Cell Significance Index: -15.2300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3165
    Cell Significance Index: -8.4500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3923
    Cell Significance Index: -16.0800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4298
    Cell Significance Index: -50.6900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4386
    Cell Significance Index: -6.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4701
    Cell Significance Index: -48.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4764
    Cell Significance Index: -36.5600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4844
    Cell Significance Index: -22.5900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5356
    Cell Significance Index: -32.8400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5903
    Cell Significance Index: -46.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6190
    Cell Significance Index: -46.1300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6539
    Cell Significance Index: -30.7400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7149
    Cell Significance Index: -48.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.7736
    Cell Significance Index: -49.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7947
    Cell Significance Index: -41.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.8083
    Cell Significance Index: -22.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.8237
    Cell Significance Index: -50.6300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8333
    Cell Significance Index: -52.5200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8565
    Cell Significance Index: -22.9100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8707
    Cell Significance Index: -23.3300
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.8738
    Cell Significance Index: -4.2500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.9211
    Cell Significance Index: -40.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.0398
    Cell Significance Index: -58.3500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.0727
    Cell Significance Index: -56.3200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.1221
    Cell Significance Index: -41.1900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -1.1639
    Cell Significance Index: -19.1800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.1955
    Cell Significance Index: -41.8800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -1.2251
    Cell Significance Index: -17.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.2535
    Cell Significance Index: -55.4500
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -1.2654
    Cell Significance Index: -8.2500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.2736
    Cell Significance Index: -23.5400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -1.2824
    Cell Significance Index: -13.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.3235
    Cell Significance Index: -46.5100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.3594
    Cell Significance Index: -47.2400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.3601
    Cell Significance Index: -40.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNASE1 is a pancreatic ribonuclease that exhibits a unique combination of enzymatic activities, including: 1. **Ribonuclease activity:** RNASE1 possesses the ability to degrade RNA, which is essential for regulating RNA metabolism, particularly in the context of viral infections and cellular stress responses. 2. **Nucleic acid binding:** RNASE1 exhibits high affinity for nucleic acids, including RNA and DNA, which enables it to interact with various nucleic acid-binding proteins and influence their activities. 3. **Autophagy regulation:** RNASE1 is involved in the regulation of autophagy, a cellular process that involves the degradation and recycling of cellular components. 4. **Extracellular exosome activity:** RNASE1 is secreted into the extracellular environment, where it can interact with exosomes and influence their functions. **Pathways and Functions:** RNASE1 is involved in various cellular pathways, including: 1. **Autophagy:** RNASE1 regulates autophagy by interacting with autophagy-related proteins and influencing the degradation of cellular components. 2. **Defense response to Gram-positive bacteria:** RNASE1 is involved in the defense response against Gram-positive bacteria, where it can degrade bacterial RNA and inhibit their growth. 3. **Defense response to viruses:** RNASE1 plays a role in the defense response against viral infections, where it can degrade viral RNA and regulate the expression of viral genes. 4. **Chaperone-mediated autophagy:** RNASE1 interacts with chaperone-mediated autophagy proteins to regulate the degradation of protein aggregates. 5. **Late endosomal microautophagy:** RNASE1 is involved in the regulation of late endosomal microautophagy, a process that involves the degradation of cellular components. **Clinical Significance:** RNASE1 has significant implications in various diseases, including: 1. **Chronic obstructive pulmonary disease (COPD):** RNASE1 is upregulated in COPD patients, where it contributes to the degradation of lung tissue and exacerbation of the disease. 2. **Pulmonary fibrosis:** RNASE1 is involved in the regulation of autophagy and extracellular matrix degradation in pulmonary fibrosis, a disease characterized by scarring of lung tissue. 3. **Cancer:** RNASE1 is overexpressed in various types of cancer, where it can contribute to tumor growth and metastasis by regulating autophagy and nucleic acid metabolism. 4. **Neurodegenerative diseases:** RNASE1 is involved in the regulation of autophagy and nucleic acid metabolism in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, RNASE1 is a multifaceted enzyme that plays a critical role in various cellular processes, including defense against pathogens, autophagy, and regulation of RNA metabolism. Its dysregulation has significant implications in various diseases, highlighting the need for further research into the mechanisms of RNASE1 and its clinical significance.

Genular Protein ID: 502872171

Symbol: RNAS1_HUMAN

Name: Ribonuclease pancreatic

UniProtKB Accession Codes:

P07998 B2R589 D3DS06 Q16830 Q16869 Q1KHR2 Q6ICS5 Q9UCB4 Q9UCB5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 27 EC 3 EMBL 11 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PIR 2 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 4 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8049276

Title: Nucleotide sequence encoding human pancreatic ribonuclease.

PubMed ID: 8049276

DOI: 10.1016/0167-4781(94)90208-9

PubMed ID: 16751256

Title: Duplication and divergence of two distinct pancreatic ribonuclease genes in leaf-eating African and Asian colobine monkeys.

PubMed ID: 16751256

DOI: 10.1093/molbev/msl025

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8588814

Title: Primary structure of the coding part of the gene for human pancreatic ribonuclease and its chromosomal location.

PubMed ID: 8588814

PubMed ID: 7649283

Title: Expression in mammalian cells, purification and characterization of recombinant human pancreatic ribonuclease.

PubMed ID: 7649283

DOI: 10.1016/0014-5793(95)96890-g

PubMed ID: 1741299

Title: The DNA sequences of the human and hamster secretory ribonucleases determined with the polymerase chain reaction (PCR).

PubMed ID: 1741299

DOI: 10.1093/nar/20.3.612

PubMed ID: 6201087

Title: The amino acid sequence of human pancreatic ribonuclease.

PubMed ID: 6201087

DOI: 10.1016/0003-2697(84)90306-3

PubMed ID: 3202829

Title: Differences in glycosylation pattern of human secretory ribonucleases.

PubMed ID: 3202829

PubMed ID: 2383019

Title: Purification and characterization of three ribonucleases from human kidney: comparison with urine ribonucleases.

PubMed ID: 2383019

DOI: 10.1016/0003-9861(90)90424-w

PubMed ID: 2049798

Title: A putative mouse oocyte maturation inhibitory protein from urine of pregnant women: N-terminal sequence homology with human nonsecretory ribonuclease.

PubMed ID: 2049798

DOI: 10.1248/cpb.39.146

PubMed ID: 1587793

Title: Characterization of a unique nonsecretory ribonuclease from urine of pregnant women.

PubMed ID: 1587793

DOI: 10.1093/oxfordjournals.jbchem.a123757

PubMed ID: 8280059

Title: Two distinct secretory ribonucleases from human cerebrum: purification, characterization and relationships to other ribonucleases.

PubMed ID: 8280059

DOI: 10.1042/bj2960617

PubMed ID: 11021969

Title: Three-dimensional structure of a human pancreatic ribonuclease variant, a step forward in the design of cytotoxic ribonucleases.

PubMed ID: 11021969

DOI: 10.1006/jmbi.2000.4506

PubMed ID: 11264578

Title: Three-dimensional structure of human RNase 1 delta N7 at 1.9 A resolution.

PubMed ID: 11264578

DOI: 10.1107/s0907444901001147

PubMed ID: 11591351

Title: The structure of an engineered domain-swapped ribonuclease dimer and its implications for the evolution of proteins toward oligomerization.

PubMed ID: 11591351

DOI: 10.1016/s0969-2126(01)00659-1

PubMed ID: 17350650

Title: Inhibition of human pancreatic ribonuclease by the human ribonuclease inhibitor protein.

PubMed ID: 17350650

DOI: 10.1016/j.jmb.2007.02.005

PubMed ID: 17586772

Title: 'Crystal lattice engineering,' an approach to engineer protein crystal contacts by creating intermolecular symmetry: crystallization and structure determination of a mutant human RNase 1 with a hydrophobic interface of leucines.

PubMed ID: 17586772

DOI: 10.1110/ps.072851407

Sequence Information:

  • Length: 156
  • Mass: 17644
  • Checksum: F63B17B8B55115F9
  • Sequence:
    • MALEKSLVRL LLLVLILLVL GWVQPSLGKE SRAKKFQRQH MDSDSSPSSS STYCNQMMRR 
RNMTQGRCKP VNTFVHEPLV DVQNVCFQEK VTCKNGQGNC YKSNSSMHIT DCRLTNGSRY 
PNCAYRTSPK ERHIIVACEG SPYVPVHFDA SVEDST

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.