Details for: STRN3

Gene ID: 29966

Symbol: STRN3

Ensembl ID: ENSG00000196792

Description: striatin 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 413.1917
    Cell Significance Index: -64.2700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 265.6091
    Cell Significance Index: -67.3700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 146.2332
    Cell Significance Index: -69.0400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 138.2130
    Cell Significance Index: -56.1500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 58.9688
    Cell Significance Index: -56.3000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 54.5599
    Cell Significance Index: -67.2700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 24.4358
    Cell Significance Index: -65.4600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 19.1538
    Cell Significance Index: -58.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.3794
    Cell Significance Index: -68.5800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.3119
    Cell Significance Index: -35.7000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.6075
    Cell Significance Index: 92.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.5694
    Cell Significance Index: 144.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.5147
    Cell Significance Index: 499.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.4208
    Cell Significance Index: 185.7700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.3049
    Cell Significance Index: 462.3600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 2.2728
    Cell Significance Index: 55.4600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.9333
    Cell Significance Index: 693.4300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.8139
    Cell Significance Index: 1254.5700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.7312
    Cell Significance Index: 37.0100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.6514
    Cell Significance Index: 1491.1000
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 1.6411
    Cell Significance Index: 26.4800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.6192
    Cell Significance Index: 45.2500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.2994
    Cell Significance Index: 25.3600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.2069
    Cell Significance Index: 20.3300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9045
    Cell Significance Index: 147.1100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8307
    Cell Significance Index: 55.8600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7868
    Cell Significance Index: 85.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6739
    Cell Significance Index: 19.4200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.6258
    Cell Significance Index: 10.0400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6143
    Cell Significance Index: 32.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.6059
    Cell Significance Index: 1140.7800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.5483
    Cell Significance Index: 248.8400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5441
    Cell Significance Index: 24.6600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.5340
    Cell Significance Index: 7.6800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5017
    Cell Significance Index: 10.8700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5004
    Cell Significance Index: 18.9500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4709
    Cell Significance Index: 20.8300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4176
    Cell Significance Index: 75.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.3981
    Cell Significance Index: 252.8500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3956
    Cell Significance Index: 48.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3495
    Cell Significance Index: 48.0000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3331
    Cell Significance Index: 20.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3221
    Cell Significance Index: 175.9200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2810
    Cell Significance Index: 432.6100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2686
    Cell Significance Index: 118.7500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2519
    Cell Significance Index: 47.9400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2493
    Cell Significance Index: 459.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2488
    Cell Significance Index: 24.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1994
    Cell Significance Index: 271.1400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1958
    Cell Significance Index: 3.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1796
    Cell Significance Index: 6.3100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1034
    Cell Significance Index: 2.9500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0253
    Cell Significance Index: 1.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0041
    Cell Significance Index: 0.1100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0264
    Cell Significance Index: -0.3900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0365
    Cell Significance Index: -4.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0449
    Cell Significance Index: -4.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0523
    Cell Significance Index: -38.3800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0742
    Cell Significance Index: -55.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0778
    Cell Significance Index: -58.8600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1120
    Cell Significance Index: -63.1700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1220
    Cell Significance Index: -76.2100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1364
    Cell Significance Index: -6.4100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1478
    Cell Significance Index: -7.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1677
    Cell Significance Index: -21.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1923
    Cell Significance Index: -32.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1968
    Cell Significance Index: -28.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2071
    Cell Significance Index: -59.5800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2077
    Cell Significance Index: -14.3700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2096
    Cell Significance Index: -3.0100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2290
    Cell Significance Index: -14.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2716
    Cell Significance Index: -20.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3226
    Cell Significance Index: -32.9500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3356
    Cell Significance Index: -39.5800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3468
    Cell Significance Index: -40.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3470
    Cell Significance Index: -73.1000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3896
    Cell Significance Index: -5.3200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4107
    Cell Significance Index: -11.0100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4186
    Cell Significance Index: -11.4000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4316
    Cell Significance Index: -6.3700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4474
    Cell Significance Index: -31.6500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4606
    Cell Significance Index: -29.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4790
    Cell Significance Index: -54.8800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5105
    Cell Significance Index: -10.5900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5264
    Cell Significance Index: -15.0900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6240
    Cell Significance Index: -3.7700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6759
    Cell Significance Index: -14.8000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6912
    Cell Significance Index: -8.2400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7221
    Cell Significance Index: -57.1900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7282
    Cell Significance Index: -38.2400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.8084
    Cell Significance Index: -10.0800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.8870
    Cell Significance Index: -6.0100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.9181
    Cell Significance Index: -15.3700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.9433
    Cell Significance Index: -57.9800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.0722
    Cell Significance Index: -37.2600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -1.0818
    Cell Significance Index: -15.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0900
    Cell Significance Index: -66.8300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.1020
    Cell Significance Index: -36.0800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.1077
    Cell Significance Index: -35.2800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.1861
    Cell Significance Index: -14.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** STRN3 is a protein-coding gene that is highly expressed in various cell types, including GABAergic neurons, ciliary muscle cells, and smooth muscle cells of the sphincter of the pupil. The STRN3 protein is a member of the striatin family, which is characterized by the presence of armadillo repeat domains. These domains are involved in protein-protein interactions and are essential for the regulation of various cellular processes. **Pathways and Functions:** STRN3 is involved in several cellular pathways, including: 1. **Armadillo repeat domain binding:** STRN3 interacts with other proteins containing armadillo repeat domains, such as calmodulin and protein phosphatase 2a. These interactions are crucial for the regulation of various cellular processes, including cell signaling and transcription. 2. **Calmodulin binding:** STRN3 binds to calmodulin, a calcium-binding protein that regulates various cellular processes, including muscle contraction and neuronal function. 3. **Dendrite regulation:** STRN3 is involved in the regulation of dendritic morphology and function, which is essential for neuronal communication and learning. 4. **Negative regulation of DNA-templated transcription:** STRN3 inhibits the activity of transcription factors, such as estrogen receptor alpha, which are involved in the regulation of gene expression. 5. **Negative regulation of intracellular estrogen receptor signaling pathway:** STRN3 also inhibits the activity of estrogen receptors, which are involved in the regulation of various cellular processes, including cell growth and differentiation. **Clinical Significance:** STRN3 has been implicated in various immune-related disorders, including: 1. **Multiple sclerosis:** STRN3 has been shown to be involved in the regulation of immune responses in multiple sclerosis, a chronic autoimmune disease that affects the central nervous system. 2. **Rheumatoid arthritis:** STRN3 has been implicated in the regulation of immune responses in rheumatoid arthritis, a chronic autoimmune disease that affects the joints. 3. **Autoimmune disorders:** STRN3 has been shown to be involved in the regulation of immune responses in various autoimmune disorders, including lupus and type 1 diabetes. In conclusion, STRN3 is a protein-coding gene that plays a crucial role in immune regulation, neuronal function, and cell signaling. Its dysregulation has been implicated in various immune-related disorders, highlighting the importance of further research into the mechanisms of STRN3 in the immune system. **Recommendations:** Further research is needed to fully understand the mechanisms of STRN3 in the immune system and its implications in disease. Some potential areas of investigation include: 1. **Immunohistochemistry:** The use of immunohistochemistry to study the expression of STRN3 in various tissues and cell types. 2. **Cytokine analysis:** The analysis of cytokine levels in STRN3-deficient mice to understand the impact of STRN3 on immune responses. 3. **Cell culture studies:** The use of cell culture models to study the effects of STRN3 on immune cell function and cytokine production. By further investigating the mechanisms of STRN3, we can gain a better understanding of its role in the immune system and develop new therapeutic strategies for immune-related disorders.

Genular Protein ID: 2930612675

Symbol: STRN3_HUMAN

Name: Striatin-3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7864889

Title: A cell-cycle nuclear autoantigen containing WD-40 motifs expressed mainly in S and G2 phase cells.

PubMed ID: 7864889

DOI: 10.1006/bbrc.1995.1288

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10748158

Title: Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain.

PubMed ID: 10748158

DOI: 10.1074/jbc.m909782199

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 18782753

Title: A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein.

PubMed ID: 18782753

DOI: 10.1074/mcp.m800266-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25743393

Title: CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling.

PubMed ID: 25743393

DOI: 10.1038/ncomms7449

PubMed ID: 26876214

Title: STRIPAK complexes in cell signaling and cancer.

PubMed ID: 26876214

DOI: 10.1038/onc.2016.9

PubMed ID: 30622739

Title: Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling.

PubMed ID: 30622739

DOI: 10.1038/s41421-018-0077-3

PubMed ID: 33633399

Title: Cryo-EM structure of the Hippo signaling integrator human STRIPAK.

PubMed ID: 33633399

DOI: 10.1038/s41594-021-00564-y

Sequence Information:

  • Length: 797
  • Mass: 87209
  • Checksum: 2179BD257186DFB0
  • Sequence:
  • MDELAGGGGG GPGMAAPPRQ QQGPGGNLGL SPGGNGAAGG GGPPASEGAG PAAGPELSRP 
    QQYTIPGILH YIQHEWARFE MERAHWEVER AELQARIAFL QGERKGQENL KKDLVRRIKM 
    LEYALKQERA KYHKLKYGTE LNQGDLKMPT FESEETKDTE APTAPQNSQL TWKQGRQLLR 
    QYLQEVGYTD TILDVRSQRV RSLLGLSNSE PNGSVETKNL EQILNGGESP KQKGQEIKRS 
    SGDVLETFNF LENADDSDED EENDMIEGIP EGKDKHRMNK HKIGNEGLAA DLTDDPDTEE 
    ALKEFDFLVT AEDGEGAGEA RSSGDGTEWD KDDLSPTAEV WDVDQGLISK LKEQYKKERK 
    GKKGVKRANR TKLYDMIADL GDDELPHIPS GIINQSRSAS TRMTDHEGAR AEEAEPITFP 
    SGGGKSFIMG SDDVLLSVLG LGDLADLTVT NDADYSYDLP ANKDAFRKTW NPKYTLRSHF 
    DGVRALAFHP VEPVLVTASE DHTLKLWNLQ KTVPAKKSAS LDVEPIYTFR AHIGPVLSLA 
    ISSNGEQCFS GGIDATIQWW NMPSPSVDPY DTYEPNVLAG TLVGHTDAVW GLAYSGIKNQ 
    LLSCSADGTV RLWNPQEKLP CICTYNGDKK HGIPTSVDFI GCDPAHMVTS FNTGSAVIYD 
    LETSQSLVIL SSQVDSGLQS NNHINRVVSH PTLPVTITAH EDRHIKFFDN KTGKMIHSMV 
    AHLDAVTSLA VDPNGIYLMS GSHDCSIRLW NLDSKTCVQE ITAHRKKLDE SIYDVAFHSS 
    KAYIASAGAD ALAKVFV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.