Gene ID2 - ENSG00000115738 | NCBI Gene ID: 3398

Details for: ID2

Gene ID: 3398

Symbol: ID2

Ensembl ID: ENSG00000115738

Description: inhibitor of DNA binding 2

Associated with

Ngf-stimulated transcription
(R-HSA-9031628)
Nuclear events (kinase and transcription factor activation)
(R-HSA-198725)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Bundle of his development
(GO:0003166)
Cell differentiation
(GO:0030154)
Cellular senescence
(GO:0090398)
Circadian regulation of gene expression
(GO:0032922)
Circadian rhythm
(GO:0007623)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Embryonic digestive tract morphogenesis
(GO:0048557)
Endodermal digestive tract morphogenesis
(GO:0061031)
Entrainment of circadian clock by photoperiod
(GO:0043153)
Enucleate erythrocyte differentiation
(GO:0043353)
Epithelial cell differentiation involved in mammary gland alveolus development
(GO:0061030)
Euchromatin
(GO:0000791)
Heart development
(GO:0007507)
Locomotor rhythm
(GO:0045475)
Mammary gland alveolus development
(GO:0060749)
Mammary gland epithelial cell proliferation
(GO:0033598)
Negative regulation of b cell differentiation
(GO:0045578)
Negative regulation of dna-binding transcription factor activity
(GO:0043433)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of muscle cell differentiation
(GO:0051148)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neuron fate commitment
(GO:0048663)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Olfactory bulb development
(GO:0021772)
Positive regulation of astrocyte differentiation
(GO:0048711)
Positive regulation of blood pressure
(GO:0045777)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of fat cell differentiation
(GO:0045600)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of macrophage differentiation
(GO:0045651)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Regulation of circadian rhythm
(GO:0042752)
Regulation of g1/s transition of mitotic cell cycle
(GO:2000045)
Regulation of lipid metabolic process
(GO:0019216)
Regulation of neural precursor cell proliferation
(GO:2000177)
Regulation of neuron differentiation
(GO:0045664)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Transcription regulator activity
(GO:0140110)
Transcription regulator inhibitor activity
(GO:0140416)
Transmembrane transporter binding
(GO:0044325)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 4.37
Marker Score: 12741.5
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 4.25
Marker Score: 11728.5
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 4.08
Marker Score: 3196.5
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 3.38
Marker Score: 2455
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 3.38
Marker Score: 1802.5
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 3.34
Marker Score: 3707.5
Cell Name: mature T cell (CL0002419)
Fold Change: 3.15
Marker Score: 31171
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 2.98
Marker Score: 1530
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 2.98
Marker Score: 1643
Cell Name: memory T cell (CL0000813)
Fold Change: 2.88
Marker Score: 1239
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 2.85
Marker Score: 2399
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 2.83
Marker Score: 7936
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 2.81
Marker Score: 4328
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 2.79
Marker Score: 1638
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 2.74
Marker Score: 880.5
Cell Name: basophil (CL0000767)
Fold Change: 2.72
Marker Score: 1291
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 2.65
Marker Score: 3455
Cell Name: granulocyte (CL0000094)
Fold Change: 2.64
Marker Score: 1182
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 2.64
Marker Score: 1076.5
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 2.59
Marker Score: 2308
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 2.58
Marker Score: 5388
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 2.57
Marker Score: 1108
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 2.53
Marker Score: 785
Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 2.53
Marker Score: 833
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 2.49
Marker Score: 6529
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.44
Marker Score: 136674
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 2.44
Marker Score: 5752
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 2.43
Marker Score: 7661
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 2.43
Marker Score: 789
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 2.43
Marker Score: 747
Cell Name: Kupffer cell (CL0000091)
Fold Change: 2.4
Marker Score: 2398
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 2.38
Marker Score: 2033
Cell Name: Mueller cell (CL0000636)
Fold Change: 2.37
Marker Score: 3281
Cell Name: kidney cell (CL1000497)
Fold Change: 2.33
Marker Score: 1553
Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 2.3
Marker Score: 534
Cell Name: exhausted T cell (CL0011025)
Fold Change: 2.29
Marker Score: 1320
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 2.29
Marker Score: 4580.5
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 2.29
Marker Score: 3888
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 2.27
Marker Score: 2744
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 2.26
Marker Score: 5465
Cell Name: chondrocyte (CL0000138)
Fold Change: 2.24
Marker Score: 1010
Cell Name: theca cell (CL0000503)
Fold Change: 2.23
Marker Score: 1597
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 2.21
Marker Score: 2114
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 2.17
Marker Score: 4890
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 2.17
Marker Score: 2292
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 2.17
Marker Score: 3525
Cell Name: dendritic cell (CL0000451)
Fold Change: 2.13
Marker Score: 1462
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 2.12
Marker Score: 4136
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.11
Marker Score: 13480
Cell Name: lung secretory cell (CL1000272)
Fold Change: 2.1
Marker Score: 1872.5
Cell Name: natural killer cell (CL0000623)
Fold Change: 2.08
Marker Score: 2697
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 2.08
Marker Score: 787
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 2.08
Marker Score: 747
Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
Fold Change: 2.05
Marker Score: 463.5
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.05
Marker Score: 3013.5
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 2.03
Marker Score: 2802
Cell Name: mature astrocyte (CL0002627)
Fold Change: 2.02
Marker Score: 1326
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 2
Marker Score: 1101
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.98
Marker Score: 7798
Cell Name: blood cell (CL0000081)
Fold Change: 1.98
Marker Score: 23032
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 1.98
Marker Score: 1680
Cell Name: enterocyte (CL0000584)
Fold Change: 1.97
Marker Score: 9478
Cell Name: type I NK T cell (CL0000921)
Fold Change: 1.97
Marker Score: 1545.5
Cell Name: hepatocyte (CL0000182)
Fold Change: 1.97
Marker Score: 1344
Cell Name: decidual cell (CL2000002)
Fold Change: 1.96
Marker Score: 8434
Cell Name: papillary tips cell (CL1000597)
Fold Change: 1.95
Marker Score: 394.5
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.95
Marker Score: 21962
Cell Name: lymphocyte (CL0000542)
Fold Change: 1.94
Marker Score: 982
Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 1.94
Marker Score: 427
Cell Name: myelocyte (CL0002193)
Fold Change: 1.94
Marker Score: 838
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 1.9
Marker Score: 1194
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 1.9
Marker Score: 3391
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 1.89
Marker Score: 5950
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.89
Marker Score: 452.5
Cell Name: B-1b B cell (CL0000821)
Fold Change: 1.89
Marker Score: 435.5
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 1.89
Marker Score: 1342
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 1.89
Marker Score: 1624
Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.88
Marker Score: 4271
Cell Name: stromal cell (CL0000499)
Fold Change: 1.88
Marker Score: 2202
Cell Name: lung macrophage (CL1001603)
Fold Change: 1.88
Marker Score: 2148
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 1.86
Marker Score: 1342
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 1.86
Marker Score: 1248
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.85
Marker Score: 64126
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.85
Marker Score: 2073
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 1.85
Marker Score: 47266
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 1.85
Marker Score: 1627
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.84
Marker Score: 432
Cell Name: ependymal cell (CL0000065)
Fold Change: 1.83
Marker Score: 639
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.82
Marker Score: 1815
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 1.81
Marker Score: 1612
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 1.81
Marker Score: 1245
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 1.8
Marker Score: 1196
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: 1.79
Marker Score: 754
Cell Name: B-1a B cell (CL0000820)
Fold Change: 1.79
Marker Score: 429.5
Cell Name: pre-B-I cell (CL0000956)
Fold Change: 1.79
Marker Score: 457.5
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 1.79
Marker Score: 567
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 1.79
Marker Score: 350
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 1.79
Marker Score: 2454
Cell Name: astrocyte (CL0000127)
Fold Change: 1.78
Marker Score: 1546.5
Cell Name: leukocyte (CL0000738)
Fold Change: 1.78
Marker Score: 1023

Hover over a box to see details here...

**Key characteristics:** * ID2 is a protein that binds to DNA and inhibits its binding to RNA polymerase II. * ID2 is expressed in high levels in NKp46-positive innate lymphoid cells, human decidual natural killer cells, human thymic cells, and renal intercalated cells. * ID2 is a key regulator of the development of the heart. * ID2 is involved in the regulation of the circadian rhythm. **Pathways and functions:** * ID2 inhibits the binding of DNA to RNA polymerase II, which is essential for the initiation of transcription. * ID2 is involved in the negative regulation of transcription by RNA polymerase II. * ID2 is involved in the development of the heart. * ID2 is involved in the regulation of the circadian rhythm. **Clinical significance:** ID2 is a potential therapeutic target for a variety of diseases, including cancer, autoimmune disorders, and neurodegenerative diseases. ID2 inhibitors are being investigated as potential treatments for these diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

DNA-binding protein inhibitor ID-2

Genular Protein ID: 1920070823

Symbol: ID2_HUMAN

Name: DNA-binding protein inhibitor ID-2

UniProtKB Accession Codes:

Q02363

Database IDs:

Citations:

PubMed ID: 8294468

Title: Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts.

PubMed ID: 8294468

DOI: 10.1016/s0021-9258(17)42146-6

PubMed ID: 1741406

Title: A human Id-like helix-loop-helix protein expressed during early development.

PubMed ID: 1741406

DOI: 10.1073/pnas.89.4.1512

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10502414

Title: Dimerization of the docking/adaptor protein HEF1 via a carboxy-terminal helix-loop-helix domain.

PubMed ID: 10502414

DOI: 10.1006/excr.1999.4609

PubMed ID: 14752053

Title: Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD.

PubMed ID: 14752053

DOI: 10.1210/me.2003-0311

PubMed ID: 20861012

Title: The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression.

PubMed ID: 20861012

DOI: 10.1074/jbc.m110.175182

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

Length: 134
Mass: 14917
Checksum: A0D98B96396EB11E
Sequence:

MKAFSPVRSV RKNSLSDHSL GISRSKTPVD DPMSLLYNMN DCYSKLKELV PSIPQNKKVS 
KMEILQHVID YILDLQIALD SHPTIVSLHH QRPGQNQASR TPLTTLNTDI SILSLQASEF 
PSELMSNDSK ALCG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: ID2

Associated with

Cells (max top 100)

Other Information

Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts. PubMed ID: 8294468

A human Id-like helix-loop-helix protein expressed during early development. PubMed ID: 1741406

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Dimerization of the docking/adaptor protein HEF1 via a carboxy-terminal helix-loop-helix domain. PubMed ID: 10502414

Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD. PubMed ID: 14752053

The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression. PubMed ID: 20861012

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569