Details for: ID2

Gene ID: 3398

Symbol: ID2

Ensembl ID: ENSG00000115738

Description: inhibitor of DNA binding 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 498.5045
    Cell Significance Index: -77.5400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 281.8524
    Cell Significance Index: -71.4900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 209.2742
    Cell Significance Index: -86.2100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 188.8890
    Cell Significance Index: -76.7400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 179.7414
    Cell Significance Index: -84.8600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 165.5180
    Cell Significance Index: -85.1400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 126.6128
    Cell Significance Index: -84.9600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 82.3782
    Cell Significance Index: -78.6500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 63.4654
    Cell Significance Index: -78.2500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 21.0877
    Cell Significance Index: -64.7700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 20.9703
    Cell Significance Index: -82.7500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.3602
    Cell Significance Index: -29.2400
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 9.6365
    Cell Significance Index: 25.8200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 9.2996
    Cell Significance Index: 74.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 7.1339
    Cell Significance Index: 914.5200
  • Cell Name: theca cell (CL0000503)
    Fold Change: 5.8144
    Cell Significance Index: 34.1600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.2711
    Cell Significance Index: 89.4000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 3.2654
    Cell Significance Index: 113.4700
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 3.0078
    Cell Significance Index: 11.2100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.4247
    Cell Significance Index: 71.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.4165
    Cell Significance Index: 331.8500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.2307
    Cell Significance Index: 41.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.8732
    Cell Significance Index: 337.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.6002
    Cell Significance Index: 873.9100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3710
    Cell Significance Index: 135.6200
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 1.3184
    Cell Significance Index: 22.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2969
    Cell Significance Index: 159.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.2294
    Cell Significance Index: 64.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0195
    Cell Significance Index: 202.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0162
    Cell Significance Index: 52.7900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.9430
    Cell Significance Index: 15.8900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9328
    Cell Significance Index: 42.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8023
    Cell Significance Index: 51.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7938
    Cell Significance Index: 350.9700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7610
    Cell Significance Index: 82.7800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7537
    Cell Significance Index: 151.1900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.7382
    Cell Significance Index: 13.0500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7377
    Cell Significance Index: 666.1300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7256
    Cell Significance Index: 51.3200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4849
    Cell Significance Index: 13.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4264
    Cell Significance Index: 20.0400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4201
    Cell Significance Index: 68.3300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3820
    Cell Significance Index: 17.8100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3115
    Cell Significance Index: 8.9300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2974
    Cell Significance Index: 56.5900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2423
    Cell Significance Index: 5.2500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2152
    Cell Significance Index: 2.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2145
    Cell Significance Index: 76.9600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2056
    Cell Significance Index: 3.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1690
    Cell Significance Index: 21.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0988
    Cell Significance Index: 72.4300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0440
    Cell Significance Index: 82.8600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0230
    Cell Significance Index: 2.6300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0193
    Cell Significance Index: 14.6400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0098
    Cell Significance Index: 0.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0078
    Cell Significance Index: -4.8500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0143
    Cell Significance Index: -1.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0197
    Cell Significance Index: -30.3300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0400
    Cell Significance Index: -54.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0510
    Cell Significance Index: -37.7700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0520
    Cell Significance Index: -95.9400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0752
    Cell Significance Index: -12.8500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0810
    Cell Significance Index: -0.9200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0872
    Cell Significance Index: -1.4600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.1000
    Cell Significance Index: -69.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1123
    Cell Significance Index: -63.3500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1152
    Cell Significance Index: -73.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1612
    Cell Significance Index: -73.1700
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.1710
    Cell Significance Index: -0.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2042
    Cell Significance Index: -43.0200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2171
    Cell Significance Index: -5.9100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2286
    Cell Significance Index: -6.1100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2404
    Cell Significance Index: -6.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2524
    Cell Significance Index: -72.6100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2527
    Cell Significance Index: -18.8300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2805
    Cell Significance Index: -4.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3159
    Cell Significance Index: -37.2600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3438
    Cell Significance Index: -19.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3588
    Cell Significance Index: -41.1100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3928
    Cell Significance Index: -8.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4150
    Cell Significance Index: -60.3300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4268
    Cell Significance Index: -33.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4447
    Cell Significance Index: -51.8300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5302
    Cell Significance Index: -16.9800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.7173
    Cell Significance Index: -44.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7837
    Cell Significance Index: -81.6100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.9172
    Cell Significance Index: -13.9300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.9493
    Cell Significance Index: -49.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.0095
    Cell Significance Index: -77.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.0631
    Cell Significance Index: -29.7100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1188
    Cell Significance Index: -68.5900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.2738
    Cell Significance Index: -85.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.3171
    Cell Significance Index: -28.0500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.3701
    Cell Significance Index: -86.3600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.3805
    Cell Significance Index: -36.3000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.6152
    Cell Significance Index: -47.5800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.7609
    Cell Significance Index: -72.1600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.8697
    Cell Significance Index: -65.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.9142
    Cell Significance Index: -84.6700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.9154
    Cell Significance Index: -47.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ID2 is a DNA-binding protein inhibitor that belongs to the ID family of transcriptional regulators. It is characterized by its ability to inhibit the activity of DNA-binding transcription factors, thereby regulating gene expression. ID2 is highly expressed in various cell types, including immune cells, epithelial cells, and neural cells. Its expression is tightly regulated by post-translational modifications, including phosphorylation and ubiquitination. **Pathways and Functions:** ID2 regulates various biological processes, including: 1. **Immune Response:** ID2 is highly expressed in immune cells, including natural killer cells, T cells, and dendritic cells. It regulates the activity of transcription factors involved in immune cell development and function. 2. **Cell Differentiation:** ID2 regulates the differentiation of various cell types, including epithelial cells, neural cells, and muscle cells. 3. **Circadian Rhythm:** ID2 is involved in the regulation of the circadian rhythm, which is essential for maintaining homeostasis and regulating various physiological processes. 4. **Gene Expression:** ID2 regulates the expression of genes involved in various biological processes, including cell growth, differentiation, and survival. **Mechanism of Action:** ID2 regulates the activity of DNA-binding transcription factors by inhibiting their ability to bind to DNA. This is achieved through the interaction of ID2 with specific transcription factors, resulting in the recruitment of histone deacetylases and other regulatory proteins. The inhibition of transcription factors by ID2 leads to the suppression of gene expression, thereby regulating various biological processes. **Clinical Significance:** Dysregulation of ID2 has been implicated in various diseases, including: 1. **Cancer:** ID2 is overexpressed in various types of cancer, including breast cancer, lung cancer, and colon cancer. Its overexpression is associated with poor prognosis and reduced survival. 2. **Autoimmune Disorders:** ID2 is highly expressed in autoimmune diseases, including rheumatoid arthritis and multiple sclerosis. Its dysregulation is associated with immune cell dysfunction and disease progression. 3. **Cardiovascular Diseases:** ID2 is involved in the regulation of cardiovascular function, and its dysregulation is associated with cardiovascular disease. In conclusion, ID2 is a critical regulator of various biological processes, including immune response, cell differentiation, and development. Its dysregulation has been implicated in various diseases, highlighting the importance of its regulation in maintaining homeostasis and preventing disease. Further research is needed to fully understand the mechanisms of ID2 regulation and its clinical significance.

Genular Protein ID: 1920070823

Symbol: ID2_HUMAN

Name: DNA-binding protein inhibitor ID-2

UniProtKB Accession Codes:

Q02363

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 ELM 1 EMBL 3 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 45 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8294468

Title: Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts.

PubMed ID: 8294468

DOI: 10.1016/s0021-9258(17)42146-6

PubMed ID: 1741406

Title: A human Id-like helix-loop-helix protein expressed during early development.

PubMed ID: 1741406

DOI: 10.1073/pnas.89.4.1512

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10502414

Title: Dimerization of the docking/adaptor protein HEF1 via a carboxy-terminal helix-loop-helix domain.

PubMed ID: 10502414

DOI: 10.1006/excr.1999.4609

PubMed ID: 14752053

Title: Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD.

PubMed ID: 14752053

DOI: 10.1210/me.2003-0311

PubMed ID: 20861012

Title: The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression.

PubMed ID: 20861012

DOI: 10.1074/jbc.m110.175182

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 134
  • Mass: 14917
  • Checksum: A0D98B96396EB11E
  • Sequence:
    • MKAFSPVRSV RKNSLSDHSL GISRSKTPVD DPMSLLYNMN DCYSKLKELV PSIPQNKKVS 
KMEILQHVID YILDLQIALD SHPTIVSLHH QRPGQNQASR TPLTTLNTDI SILSLQASEF 
PSELMSNDSK ALCG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.