Details for: MYH2

Gene ID: 4620

Symbol: MYH2

Ensembl ID: ENSG00000125414

Description: myosin heavy chain 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 5.08
    Marker Score: 32736
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3181
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.63
    Marker Score: 10813
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.24
    Marker Score: 7544
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3647
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32730
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 1.03
    Marker Score: 787
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71837
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48062
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2404
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5346
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.82
    Marker Score: 1548
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 739
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.62
    Marker Score: 186
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 438
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.52
    Marker Score: 1060
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.46
    Marker Score: 7268
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.35
    Marker Score: 2078
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.3
    Marker Score: 179
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.29
    Marker Score: 137
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.2
    Marker Score: 119.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.19
    Marker Score: 401
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.19
    Marker Score: 61
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.16
    Marker Score: 69
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.15
    Marker Score: 48
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.08
    Marker Score: 99
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.08
    Marker Score: 113
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.08
    Marker Score: 50
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.07
    Marker Score: 170.5
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.07
    Marker Score: 126
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.07
    Marker Score: 34.5
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.06
    Marker Score: 71
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.06
    Marker Score: 91
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.05
    Marker Score: 57
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.05
    Marker Score: 52
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.04
    Marker Score: 51
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.04
    Marker Score: 10
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.04
    Marker Score: 142
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.04
    Marker Score: 40
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.04
    Marker Score: 27
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.03
    Marker Score: 175
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.03
    Marker Score: 44
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.03
    Marker Score: 30
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.03
    Marker Score: 24
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.03
    Marker Score: 44
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.02
    Marker Score: 34
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.02
    Marker Score: 41
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.01
    Marker Score: 28
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.01
    Marker Score: 116
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.01
    Marker Score: 21

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Other Information

**Key characteristics:** * MYH2 is a large protein with a molecular weight of approximately 120 kDa. * It is expressed in a variety of cell types, including progenitor cells, blood vessel endothelial cells, goblet cells, neoplastic cells, abnormal cells, absorptive cells, skeletal muscle cells, cerebral cortex GABAergic interneurons, forebrain radial glial cells, and intestinal crypt stem cells of the colon. * It is a highly dynamic protein that undergoes significant conformational changes during the process of phagocytosis. **Pathways and functions:** * MYH2 is involved in actin filament binding, which is essential for the assembly and stability of actin filaments. * It is also involved in the regulation of phagocytosis, a process by which cells internalize foreign particles. * MYH2 is a key regulator of the immune system, where it is expressed on immune cells such as macrophages and dendritic cells. * It is involved in the regulation of inflammation and cell migration. * It is also involved in the regulation of muscle contraction. **Clinical significance:** * Mutations in the MYH2 gene have been linked to a number of human diseases, including cancer, cardiovascular disease, and inflammatory diseases. * Targeting MYH2 has been explored as a therapeutic strategy for these diseases. * In preclinical studies, inhibitors of MYH2 have shown promise in treating cancer and inflammatory diseases. **Additional information:** * MYH2 is a highly conserved gene, with a similar gene found in other mammals. * It is expressed in a variety of cell types, suggesting that it has a vital role in mammalian physiology. * It is a well-studied gene, with a wealth of information available on its structure and function.

Genular Protein ID: 2922942378

Symbol: MYH2_HUMAN

Name: Myosin-2

UniProtKB Accession Codes:

Q9UKX2 A0AVL4 Q14322 Q16229 Q567P6 Q86T56

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 15 Gene3D 9 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10388558

Title: Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity.

PubMed ID: 10388558

DOI: 10.1006/jmbi.1999.2865

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7545970

Title: Type IIx myosin heavy chain transcripts are expressed in type IIb fibers of human skeletal muscle.

PubMed ID: 7545970

DOI: 10.1152/ajpcell.1994.267.6.c1723

PubMed ID: 7751403

Title: Characterization of human skeletal muscle fibres according to the myosin heavy chains they express.

PubMed ID: 7751403

DOI: 10.1007/bf00125308

PubMed ID: 17823310

Title: HGAL, a lymphoma prognostic biomarker, interacts with the cytoskeleton and mediates the effects of IL-6 on cell migration.

PubMed ID: 17823310

DOI: 10.1182/blood-2007-04-087775

PubMed ID: 11114175

Title: Autosomal dominant myopathy: missense mutation (Glu-706 --> Lys) in the myosin heavy chain IIa gene.

PubMed ID: 11114175

DOI: 10.1073/pnas.250289597

PubMed ID: 15741996

Title: Mutations and sequence variation in the human myosin heavy chain IIa gene (MYH2).

PubMed ID: 15741996

DOI: 10.1038/sj.ejhg.5201375

Sequence Information:

  • Length: 1941
  • Mass: 223044
  • Checksum: 681E866F83AEA83F
  • Sequence:
    • MSSDSELAVF GEAAPFLRKS ERERIEAQNR PFDAKTSVFV AEPKESFVKG TIQSREGGKV 
TVKTEGGATL TVKDDQVFPM NPPKYDKIED MAMMTHLHEP AVLYNLKERY AAWMIYTYSG 
LFCVTVNPYK WLPVYKPEVV TAYRGKKRQE APPHIFSISD NAYQFMLTDR ENQSILITGE 
SGAGKTVNTK RVIQYFATIA VTGEKKKEEI TSGKIQGTLE DQIISANPLL EAFGNAKTVR 
NDNSSRFGKF IRIHFGTTGK LASADIETYL LEKSRVVFQL KAERSYHIFY QITSNKKPEL 
IEMLLITTNP YDYPFVSQGE ISVASIDDQE ELMATDSAID ILGFTNEEKV SIYKLTGAVM 
HYGNLKFKQK QREEQAEPDG TEVADKAAYL QSLNSADLLK ALCYPRVKVG NEYVTKGQTV 
EQVSNAVGAL AKAVYEKMFL WMVARINQQL DTKQPRQYFI GVLDIAGFEI FDFNSLEQLC 
INFTNEKLQQ FFNHHMFVLE QEEYKKEGIE WTFIDFGMDL AACIELIEKP MGIFSILEEE 
CMFPKATDTS FKNKLYDQHL GKSANFQKPK VVKGKAEAHF ALIHYAGVVD YNITGWLEKN 
KDPLNETVVG LYQKSAMKTL AQLFSGAQTA EGEGAGGGAK KGGKKKGSSF QTVSALFREN 
LNKLMTNLRS THPHFVRCII PNETKTPGAM EHELVLHQLR CNGVLEGIRI CRKGFPSRIL 
YADFKQRYKV LNASAIPEGQ FIDSKKASEK LLASIDIDHT QYKFGHTKVF FKAGLLGLLE 
EMRDDKLAQL ITRTQARCRG FLARVEYQRM VERREAIFCI QYNIRSFMNV KHWPWMKLFF 
KIKPLLKSAE TEKEMATMKE EFQKIKDELA KSEAKRKELE EKMVTLLKEK NDLQLQVQAE 
AEGLADAEER CDQLIKTKIQ LEAKIKEVTE RAEDEEEINA ELTAKKRKLE DECSELKKDI 
DDLELTLAKV EKEKHATENK VKNLTEEMAG LDETIAKLTK EKKALQEAHQ QTLDDLQAEE 
DKVNTLTKAK IKLEQQVDDL EGSLEQEKKL RMDLERAKRK LEGDLKLAQE SIMDIENEKQ 
QLDEKLKKKE FEISNLQSKI EDEQALGIQL QKKIKELQAR IEELEEEIEA ERASRAKAEK 
QRSDLSRELE EISERLEEAG GATSAQIEMN KKREAEFQKM RRDLEEATLQ HEATAATLRK 
KHADSVAELG EQIDNLQRVK QKLEKEKSEM KMEIDDLASN VETVSKAKGN LEKMCRTLED 
QLSELKSKEE EQQRLINDLT AQRGRLQTES GEFSRQLDEK EALVSQLSRG KQAFTQQIEE 
LKRQLEEEIK AKNALAHALQ SSRHDCDLLR EQYEEEQESK AELQRALSKA NTEVAQWRTK 
YETDAIQRTE ELEEAKKKLA QRLQAAEEHV EAVNAKCASL EKTKQRLQNE VEDLMLDVER 
TNAACAALDK KQRNFDKILA EWKQKCEETH AELEASQKEA RSLGTELFKI KNAYEESLDQ 
LETLKRENKN LQQEISDLTE QIAEGGKRIH ELEKIKKQVE QEKCELQAAL EEAEASLEHE 
EGKILRIQLE LNQVKSEVDR KIAEKDEEID QLKRNHIRIV ESMQSTLDAE IRSRNDAIRL 
KKKMEGDLNE MEIQLNHANR MAAEALRNYR NTQGILKDTQ IHLDDALRSQ EDLKEQLAMV 
ERRANLLQAE IEELRATLEQ TERSRKIAEQ ELLDASERVQ LLHTQNTSLI NTKKKLETDI 
SQMQGEMEDI LQEARNAEEK AKKAITDAAM MAEELKKEQD TSAHLERMKK NMEQTVKDLQ 
LRLDEAEQLA LKGGKKQIQK LEARVRELEG EVESEQKRNA EAVKGLRKHE RRVKELTYQT 
EEDRKNILRL QDLVDKLQAK VKSYKRQAEE AEEQSNTNLA KFRKLQHELE EAEERADIAE 
SQVNKLRVKS REVHTKVISE E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.