Details for: ENO3

Gene ID: 2027

Symbol: ENO3

Ensembl ID: ENSG00000108515

Description: enolase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 23.5301
    Cell Significance Index: -3.6600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 13.5623
    Cell Significance Index: -3.4400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 10.9698
    Cell Significance Index: 177.0000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 8.6891
    Cell Significance Index: -3.5300
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 6.6788
    Cell Significance Index: 19.1400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 5.0760
    Cell Significance Index: 123.8500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 3.7497
    Cell Significance Index: -3.5800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.0171
    Cell Significance Index: -3.7200
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 2.4239
    Cell Significance Index: 1.8500
  • Cell Name: secondary lymphoid organ macrophage (CL0000867)
    Fold Change: 1.8581
    Cell Significance Index: 13.6400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.4054
    Cell Significance Index: -3.7700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.3494
    Cell Significance Index: 14.6700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2730
    Cell Significance Index: 242.2600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.0714
    Cell Significance Index: 18.0200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9797
    Cell Significance Index: 26.2500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 0.9592
    Cell Significance Index: -3.7900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7844
    Cell Significance Index: 77.5900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6019
    Cell Significance Index: 46.1900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5966
    Cell Significance Index: 538.7000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.4647
    Cell Significance Index: 6.8600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4173
    Cell Significance Index: 45.3900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4072
    Cell Significance Index: 66.2300
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.3766
    Cell Significance Index: 3.8500
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.3483
    Cell Significance Index: 1.9800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3330
    Cell Significance Index: 19.9900
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.2540
    Cell Significance Index: 3.8000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2200
    Cell Significance Index: 15.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2180
    Cell Significance Index: 6.2800
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.1985
    Cell Significance Index: 2.6000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1977
    Cell Significance Index: 2.7800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1925
    Cell Significance Index: 38.2000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1861
    Cell Significance Index: 3.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1772
    Cell Significance Index: 8.0300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1403
    Cell Significance Index: 3.0400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1358
    Cell Significance Index: 3.4900
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.0810
    Cell Significance Index: 0.6700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.0651
    Cell Significance Index: 0.5200
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.0649
    Cell Significance Index: 0.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0647
    Cell Significance Index: 7.5400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0600
    Cell Significance Index: 2.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0506
    Cell Significance Index: 22.9600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0449
    Cell Significance Index: 0.7200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0301
    Cell Significance Index: 0.8400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0267
    Cell Significance Index: 1.7200
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.0192
    Cell Significance Index: 0.1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0184
    Cell Significance Index: 0.6500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0138
    Cell Significance Index: 2.4900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0135
    Cell Significance Index: 20.7400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0132
    Cell Significance Index: 0.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0106
    Cell Significance Index: 5.8100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0104
    Cell Significance Index: 0.1800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0087
    Cell Significance Index: 11.7700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0048
    Cell Significance Index: 2.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0021
    Cell Significance Index: 3.8800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0019
    Cell Significance Index: 3.5300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0014
    Cell Significance Index: 0.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0002
    Cell Significance Index: -0.1400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0009
    Cell Significance Index: -0.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0022
    Cell Significance Index: -0.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0024
    Cell Significance Index: -0.3500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0026
    Cell Significance Index: -0.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0028
    Cell Significance Index: -2.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0029
    Cell Significance Index: -2.2000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0039
    Cell Significance Index: -0.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0042
    Cell Significance Index: -1.5000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0044
    Cell Significance Index: -3.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0052
    Cell Significance Index: -1.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0052
    Cell Significance Index: -0.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0055
    Cell Significance Index: -3.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0070
    Cell Significance Index: -4.3500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0085
    Cell Significance Index: -2.4400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0093
    Cell Significance Index: -0.1600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0105
    Cell Significance Index: -0.1500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0122
    Cell Significance Index: -0.3200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0128
    Cell Significance Index: -1.5700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0140
    Cell Significance Index: -2.3900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0144
    Cell Significance Index: -0.1500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0147
    Cell Significance Index: -0.2100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0149
    Cell Significance Index: -0.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0174
    Cell Significance Index: -0.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0179
    Cell Significance Index: -0.8400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0179
    Cell Significance Index: -0.4800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0182
    Cell Significance Index: -2.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0190
    Cell Significance Index: -4.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0213
    Cell Significance Index: -2.4400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0214
    Cell Significance Index: -0.6300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0227
    Cell Significance Index: -1.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0237
    Cell Significance Index: -1.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0290
    Cell Significance Index: -1.7800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0304
    Cell Significance Index: -3.1700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0314
    Cell Significance Index: -0.3300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0390
    Cell Significance Index: -2.4600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0397
    Cell Significance Index: -1.2700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0398
    Cell Significance Index: -3.1500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0398
    Cell Significance Index: -1.0800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0415
    Cell Significance Index: -1.2200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0424
    Cell Significance Index: -0.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0447
    Cell Significance Index: -2.5100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0475
    Cell Significance Index: -2.4700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0479
    Cell Significance Index: -3.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subcellular localization:** ENO3 is predominantly found in the cytosol, where it participates in the glycolytic pathway. 2. **Protein structure:** ENO3 consists of four subunits, each containing a beta-enolase domain, which is responsible for the catalytic activity. 3. **Regulation:** ENO3 expression is tightly regulated by various signaling pathways, including those involved in energy metabolism, cell growth, and differentiation. 4. **Tissue specificity:** ENO3 is significantly expressed in cells of skeletal muscle, cardiac muscle, and other tissues, highlighting its importance in various cellular processes. **Pathways and Functions:** ENO3 plays a central role in the glycolytic pathway, which is a key energy-producing process in cells. The enzyme facilitates the conversion of 2-phosphoglycerate to enolpyruvate, a step that is essential for the production of pyruvate, which can be further metabolized to produce energy. Additionally, ENO3 is involved in other cellular processes, including: 1. **Gluconeogenesis:** ENO3 participates in the gluconeogenic pathway, which is responsible for the generation of glucose from non-carbohydrate sources. 2. **Glycolytic process:** ENO3 is a key enzyme in the glycolytic process, which is a crucial energy-producing pathway in cells. 3. **Extracellular exosome:** ENO3 is also found in the extracellular exosome, where it plays a role in the regulation of cellular signaling and metabolism. **Clinical Significance:** ENO3 has been implicated in various diseases and disorders, including: 1. **Metabolic disorders:** ENO3 has been linked to metabolic disorders, such as diabetes and obesity, where impaired glycolytic function can contribute to disease progression. 2. **Cardiovascular disease:** ENO3 has been shown to play a role in cardiovascular disease, where altered glycolytic function can contribute to cardiac dysfunction and disease progression. 3. **Cancer:** ENO3 has been implicated in cancer, where altered glycolytic function can contribute to tumor growth and progression. In conclusion, ENO3 is a critical component of the glycolytic pathway, playing a pivotal role in glucose metabolism. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of ENO3 in maintaining cellular homeostasis and overall health. Further research is needed to fully elucidate the functions and clinical significance of ENO3 in human disease.

Genular Protein ID: 1629768624

Symbol: ENOB_HUMAN

Name: Beta-enolase

UniProtKB Accession Codes:

P13929 B4DUI6 B4DUM6 D3DTL2 E7ENK8 Q96AE2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 7 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EC 1 EMBL 12 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PIRSF 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 2 RefSeq 5 Rhea 2 SABIO-RK 1 SFLD 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2587223

Title: Structure of human muscle (beta) enolase mRNA and protein deduced from a genomic clone.

PubMed ID: 2587223

DOI: 10.1093/nar/17.21.8862

PubMed ID: 2336366

Title: Nucleotide sequence of a cDNA encoding the human muscle-specific enolase (MSE).

PubMed ID: 2336366

DOI: 10.1093/nar/18.7.1893

PubMed ID: 1840492

Title: Molecular structure of the human muscle-specific enolase gene (ENO3).

PubMed ID: 1840492

DOI: 10.1042/bj2750427

PubMed ID: 8513787

Title: Structural features of the human gene for muscle-specific enolase. Differential splicing in the 5'-untranslated sequence generates two forms of mRNA.

PubMed ID: 8513787

DOI: 10.1111/j.1432-1033.1993.tb17932.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15188056

Title: Characterization of MR-1, a novel myofibrillogenesis regulator in human muscle.

PubMed ID: 15188056

DOI: 10.1093/abbs/36.6.412

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 11506403

Title: Beta-enolase deficiency, a new metabolic myopathy of distal glycolysis.

PubMed ID: 11506403

DOI: 10.1002/ana.1095

Sequence Information:

  • Length: 434
  • Mass: 46987
  • Checksum: 4D9D8DCF32CF153F
  • Sequence:
    • MAMQKIFARE ILDSRGNPTV EVDLHTAKGR FRAAVPSGAS TGIYEALELR DGDKGRYLGK 
GVLKAVENIN NTLGPALLQK KLSVVDQEKV DKFMIELDGT ENKSKFGANA ILGVSLAVCK 
AGAAEKGVPL YRHIADLAGN PDLILPVPAF NVINGGSHAG NKLAMQEFMI LPVGASSFKE 
AMRIGAEVYH HLKGVIKAKY GKDATNVGDE GGFAPNILEN NEALELLKTA IQAAGYPDKV 
VIGMDVAASE FYRNGKYDLD FKSPDDPARH ITGEKLGELY KSFIKNYPVV SIEDPFDQDD 
WATWTSFLSG VNIQIVGDDL TVTNPKRIAQ AVEKKACNCL LLKVNQIGSV TESIQACKLA 
QSNGWGVMVS HRSGETEDTF IADLVVGLCT GQIKTGAPCR SERLAKYNQL MRIEEALGDK 
AIFAGRKFRN PKAK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.