Details for: ENO3

Gene ID: 2027

Symbol: ENO3

Ensembl ID: ENSG00000108515

Description: enolase 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 3.9
    Marker Score: 2966
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.67
    Marker Score: 880
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169757
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.43
    Marker Score: 2717
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.05
    Marker Score: 2142
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71815
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48040
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 498.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.96
    Marker Score: 15065
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 452
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5233
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2734
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5282
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.8
    Marker Score: 17814
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.79
    Marker Score: 1385
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.78
    Marker Score: 467
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1252
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 387
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 669
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.69
    Marker Score: 528
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.68
    Marker Score: 1601
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.67
    Marker Score: 216
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.67
    Marker Score: 8915
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.65
    Marker Score: 260
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.64
    Marker Score: 2701
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.62
    Marker Score: 1369.5
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.6
    Marker Score: 181
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.59
    Marker Score: 294
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.54
    Marker Score: 288
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.53
    Marker Score: 251
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.52
    Marker Score: 162
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.51
    Marker Score: 699
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.47
    Marker Score: 303
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.47
    Marker Score: 134
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.46
    Marker Score: 152
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.46
    Marker Score: 1620
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.43
    Marker Score: 203
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.42
    Marker Score: 264
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.41
    Marker Score: 107
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.39
    Marker Score: 1276
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.38
    Marker Score: 168
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.37
    Marker Score: 535
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.36
    Marker Score: 151
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.36
    Marker Score: 270
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.35
    Marker Score: 1295
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.33
    Marker Score: 1989
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.32
    Marker Score: 356
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.31
    Marker Score: 183
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.29
    Marker Score: 93
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.29
    Marker Score: 477
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.28
    Marker Score: 164
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.28
    Marker Score: 184
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.28
    Marker Score: 134
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.28
    Marker Score: 345
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.27
    Marker Score: 71
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.27
    Marker Score: 270
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.26
    Marker Score: 536
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.25
    Marker Score: 164
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.24
    Marker Score: 4304
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.24
    Marker Score: 228
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.23
    Marker Score: 124
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.22
    Marker Score: 217
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.22
    Marker Score: 269
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.22
    Marker Score: 952
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.22
    Marker Score: 233
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.21
    Marker Score: 61
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.21
    Marker Score: 257
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.21
    Marker Score: 140
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.21
    Marker Score: 79
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 70.5
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.2
    Marker Score: 99
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.2
    Marker Score: 344
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.2
    Marker Score: 100
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.2
    Marker Score: 103
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.19
    Marker Score: 51
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.19
    Marker Score: 125
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.19
    Marker Score: 109
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.19
    Marker Score: 185
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.18
    Marker Score: 196
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.18
    Marker Score: 981
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.18
    Marker Score: 292
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.18
    Marker Score: 75.5
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.18
    Marker Score: 695
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.17
    Marker Score: 104
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.17
    Marker Score: 350
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.17
    Marker Score: 77
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.17
    Marker Score: 306
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.16
    Marker Score: 112
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.16
    Marker Score: 110
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.16
    Marker Score: 139
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.16
    Marker Score: 207
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.16
    Marker Score: 35
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.16
    Marker Score: 446
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.15
    Marker Score: 88
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.15
    Marker Score: 35

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Other Information

**Key characteristics:** - ENOLA3 is a glycolytic enzyme that catalyzes the conversion of 3-phosphoglycerate to 2-phosphoglycerate. - It is a key enzyme in the citric acid cycle, which is a central pathway for the generation of energy in cells. - ENOLA3 is also involved in the regulation of calcium homeostasis, as it is a key regulator of calcium release from intracellular stores. **Pathways and functions:** - ENOLA3 is involved in both canonical and non-canonical glycolysis pathways. - In the canonical glycolysis pathway, ENOLA3 is responsible for the formation of 3-phosphoglycerate from phosphoenolpyruvate. - In the non-canonical glycolysis pathway, ENOLA3 is involved in the production of pyruvate from oxaloacetate. - ENOLA3 also plays a role in the metabolism of carbohydrates, as it is involved in the production of glucose from gluconeogenic precursors. - The protein is also involved in the metabolism of proteins and lipids. **Clinical significance:** - Mutations in ENOLA3 have been linked to a number of human diseases, including diabetes, heart disease, and cancer. - ENOLA3 is a potential therapeutic target for these diseases, as it is a key enzyme in the metabolic pathways that are affected by these conditions.

Genular Protein ID: 1629768624

Symbol: ENOB_HUMAN

Name: Beta-enolase

UniProtKB Accession Codes:

P13929 B4DUI6 B4DUM6 D3DTL2 E7ENK8 Q96AE2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 7 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EC 1 EMBL 12 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PIRSF 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 2 RefSeq 5 Rhea 2 SABIO-RK 1 SFLD 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2587223

Title: Structure of human muscle (beta) enolase mRNA and protein deduced from a genomic clone.

PubMed ID: 2587223

DOI: 10.1093/nar/17.21.8862

PubMed ID: 2336366

Title: Nucleotide sequence of a cDNA encoding the human muscle-specific enolase (MSE).

PubMed ID: 2336366

DOI: 10.1093/nar/18.7.1893

PubMed ID: 1840492

Title: Molecular structure of the human muscle-specific enolase gene (ENO3).

PubMed ID: 1840492

DOI: 10.1042/bj2750427

PubMed ID: 8513787

Title: Structural features of the human gene for muscle-specific enolase. Differential splicing in the 5'-untranslated sequence generates two forms of mRNA.

PubMed ID: 8513787

DOI: 10.1111/j.1432-1033.1993.tb17932.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15188056

Title: Characterization of MR-1, a novel myofibrillogenesis regulator in human muscle.

PubMed ID: 15188056

DOI: 10.1093/abbs/36.6.412

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 11506403

Title: Beta-enolase deficiency, a new metabolic myopathy of distal glycolysis.

PubMed ID: 11506403

DOI: 10.1002/ana.1095

Sequence Information:

  • Length: 434
  • Mass: 46987
  • Checksum: 4D9D8DCF32CF153F
  • Sequence:
    • MAMQKIFARE ILDSRGNPTV EVDLHTAKGR FRAAVPSGAS TGIYEALELR DGDKGRYLGK 
GVLKAVENIN NTLGPALLQK KLSVVDQEKV DKFMIELDGT ENKSKFGANA ILGVSLAVCK 
AGAAEKGVPL YRHIADLAGN PDLILPVPAF NVINGGSHAG NKLAMQEFMI LPVGASSFKE 
AMRIGAEVYH HLKGVIKAKY GKDATNVGDE GGFAPNILEN NEALELLKTA IQAAGYPDKV 
VIGMDVAASE FYRNGKYDLD FKSPDDPARH ITGEKLGELY KSFIKNYPVV SIEDPFDQDD 
WATWTSFLSG VNIQIVGDDL TVTNPKRIAQ AVEKKACNCL LLKVNQIGSV TESIQACKLA 
QSNGWGVMVS HRSGETEDTF IADLVVGLCT GQIKTGAPCR SERLAKYNQL MRIEEALGDK 
AIFAGRKFRN PKAK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.