Details for: MYF6

Gene ID: 4618

Symbol: MYF6

Ensembl ID: ENSG00000111046

Description: myogenic factor 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 10.3814
    Cell Significance Index: 253.3000
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 9.6070
    Cell Significance Index: 155.0100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.8599
    Cell Significance Index: 20.2200
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.4866
    Cell Significance Index: 15.5200
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.9639
    Cell Significance Index: 6.5900
  • Cell Name: tongue muscle cell (CL0002673)
    Fold Change: 0.6650
    Cell Significance Index: 4.9800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.4836
    Cell Significance Index: 12.4300
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.3371
    Cell Significance Index: 4.4200
  • Cell Name: secondary lymphoid organ macrophage (CL0000867)
    Fold Change: 0.2765
    Cell Significance Index: 2.0300
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.2159
    Cell Significance Index: 3.2300
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.0554
    Cell Significance Index: 0.4100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0366
    Cell Significance Index: 0.5800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0084
    Cell Significance Index: 0.4400
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0008
    Cell Significance Index: -1.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0018
    Cell Significance Index: -1.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0025
    Cell Significance Index: -1.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0035
    Cell Significance Index: -1.0000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0035
    Cell Significance Index: -1.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0042
    Cell Significance Index: -0.8400
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: -0.0044
    Cell Significance Index: -0.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0045
    Cell Significance Index: -0.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0046
    Cell Significance Index: -0.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0120
    Cell Significance Index: -1.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0123
    Cell Significance Index: -1.2600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0139
    Cell Significance Index: -1.6400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0149
    Cell Significance Index: -1.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0183
    Cell Significance Index: -1.4500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0190
    Cell Significance Index: -1.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0206
    Cell Significance Index: -1.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0220
    Cell Significance Index: -1.4800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0234
    Cell Significance Index: -1.0900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0255
    Cell Significance Index: -1.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0264
    Cell Significance Index: -1.3700
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0306
    Cell Significance Index: -0.4300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0307
    Cell Significance Index: -1.3600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0311
    Cell Significance Index: -0.6500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0318
    Cell Significance Index: -0.3900
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.0322
    Cell Significance Index: -0.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0324
    Cell Significance Index: -1.7000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0377
    Cell Significance Index: -0.5400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0380
    Cell Significance Index: -1.0000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0388
    Cell Significance Index: -0.8500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0400
    Cell Significance Index: -0.3200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0404
    Cell Significance Index: -1.1900
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0414
    Cell Significance Index: -0.4600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0425
    Cell Significance Index: -1.4900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0444
    Cell Significance Index: -1.1900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0462
    Cell Significance Index: -1.7500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0468
    Cell Significance Index: -1.4900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0477
    Cell Significance Index: -1.1900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0492
    Cell Significance Index: -1.6100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0513
    Cell Significance Index: -1.3700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0514
    Cell Significance Index: -1.3100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0571
    Cell Significance Index: -0.9600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0579
    Cell Significance Index: -1.4500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0583
    Cell Significance Index: -0.9600
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.0598
    Cell Significance Index: -0.5700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0609
    Cell Significance Index: -3.0800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0613
    Cell Significance Index: -1.0500
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0640
    Cell Significance Index: -0.6600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0642
    Cell Significance Index: -1.5400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0658
    Cell Significance Index: -1.7600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0667
    Cell Significance Index: -1.3300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0669
    Cell Significance Index: -1.6700
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.0679
    Cell Significance Index: -0.6500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0701
    Cell Significance Index: -1.5200
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0709
    Cell Significance Index: -0.5900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0716
    Cell Significance Index: -1.4000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0731
    Cell Significance Index: -1.2500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0733
    Cell Significance Index: -1.3600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0735
    Cell Significance Index: -0.9800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0740
    Cell Significance Index: -1.5700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0771
    Cell Significance Index: -1.6100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0777
    Cell Significance Index: -1.5600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0799
    Cell Significance Index: -1.5800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0803
    Cell Significance Index: -1.1600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0806
    Cell Significance Index: -2.3100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0820
    Cell Significance Index: -1.3800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0829
    Cell Significance Index: -1.1500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0889
    Cell Significance Index: -1.4400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0889
    Cell Significance Index: -1.7500
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: -0.0893
    Cell Significance Index: -0.8100
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0936
    Cell Significance Index: -1.4000
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0943
    Cell Significance Index: -1.2900
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0950
    Cell Significance Index: -1.1300
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0979
    Cell Significance Index: -1.2400
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0989
    Cell Significance Index: -1.2800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0991
    Cell Significance Index: -1.5900
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0992
    Cell Significance Index: -1.3600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0995
    Cell Significance Index: -2.4100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1001
    Cell Significance Index: -1.7300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1002
    Cell Significance Index: -1.4800
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.1007
    Cell Significance Index: -1.1700
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.1013
    Cell Significance Index: -1.1500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1015
    Cell Significance Index: -1.3000
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.1028
    Cell Significance Index: -1.1700
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.1034
    Cell Significance Index: -1.1400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1041
    Cell Significance Index: -1.4600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1062
    Cell Significance Index: -1.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MYF6 is a member of the myogenic factor family, which includes other transcriptional regulators such as MyoD and Myf5. It is characterized by its ability to bind to specific DNA sequences, including E-box motifs, and to interact with RNA polymerase II and other transcription factors. MYF6 is also known to be involved in the regulation of protein dimerization and sequence-specific double-stranded DNA binding. **Pathways and Functions:** MYF6 is involved in several signaling pathways that regulate muscle development and differentiation. These include: 1. **Myogenesis:** MYF6 regulates the expression of genes involved in muscle cell differentiation, including the transcriptional activation of myosin heavy chain (MHC) and other muscle-specific genes. 2. **Skeletal muscle tissue development:** MYF6 is involved in the regulation of skeletal muscle fiber development, including the expression of genes involved in muscle fiber formation and differentiation. 3. **Somitogenesis:** MYF6 plays a role in the development of somites, which are precursor structures that give rise to skeletal muscle, vertebrae, and other tissues. 4. **Muscle cell fate commitment:** MYF6 regulates the expression of genes involved in muscle cell fate determination, including the transcriptional activation of muscle-specific genes. **Clinical Significance:** Dysregulation of MYF6 has been implicated in various muscle-related disorders, including: 1. **Muscular dystrophy:** Mutations in the MYF6 gene have been associated with certain types of muscular dystrophy, including limb-girdle muscular dystrophy type 1B. 2. **Skeletal muscle disorders:** MYF6 has been implicated in the regulation of skeletal muscle function and may play a role in the development of skeletal muscle disorders, such as myasthenia gravis. 3. **Muscle development disorders:** MYF6 is involved in the regulation of muscle development and may play a role in the development of muscle development disorders, such as achondroplasia. In conclusion, MYF6 is a critical regulator of muscle development and differentiation, and its dysregulation has been implicated in various muscle-related disorders. Further research is needed to fully understand the role of MYF6 in regulating muscle development and differentiation, and to explore its potential as a therapeutic target for muscle-related disorders.

Genular Protein ID: 3964615718

Symbol: MYF6_HUMAN

Name: Myogenic factor 6

UniProtKB Accession Codes:

P23409 B2R898 Q53X80 Q6FHI9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2311584

Title: Myf-6, a new member of the human gene family of myogenic determination factors: evidence for a gene cluster on chromosome 12.

PubMed ID: 2311584

DOI: 10.1002/j.1460-2075.1990.tb08179.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11053684

Title: Heterozygous myogenic factor 6 mutation associated with myopathy and severe course of Becker muscular dystrophy.

PubMed ID: 11053684

DOI: 10.1016/s0960-8966(00)00150-4

Sequence Information:

  • Length: 242
  • Mass: 26953
  • Checksum: 33FA8E5E54317241
  • Sequence:
    • MMMDLFETGS YFFYLDGENV TLQPLEVAEG SPLYPGSDGT LSPCQDQMPP EAGSDSSGEE 
HVLAPPGLQP PHCPGQCLIW ACKTCKRKSA PTDRRKAATL RERRRLKKIN EAFEALKRRT 
VANPNQRLPK VEILRSAISY IERLQDLLHR LDQQEKMQEL GVDPFSYRPK QENLEGADFL 
RTCSSQWPSV SDHSRGLVIT AKEGGASIDS SASSSLRCLS SIVDSISSEE RKLPCVEEVV 
EK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.