Details for: NFIA
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 859.2999
Cell Significance Index: -133.6600 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 598.9906
Cell Significance Index: -151.9300 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 314.6110
Cell Significance Index: -148.5400 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 282.2104
Cell Significance Index: -114.6500 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 269.8367
Cell Significance Index: -138.8000 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 221.8630
Cell Significance Index: -148.8800 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 122.5754
Cell Significance Index: -151.1300 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 119.9904
Cell Significance Index: -114.5600 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 53.5097
Cell Significance Index: -143.3500 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 46.9435
Cell Significance Index: -102.7400 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 39.1480
Cell Significance Index: -154.4800 - Cell Name: preadipocyte (CL0002334)
Fold Change: 8.1277
Cell Significance Index: 158.6300 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 7.6139
Cell Significance Index: 130.4800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 5.9190
Cell Significance Index: 165.4200 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 4.8175
Cell Significance Index: 102.9800 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 4.7657
Cell Significance Index: 365.7200 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 3.9205
Cell Significance Index: 66.0400 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: 3.3082
Cell Significance Index: 46.2600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 3.2350
Cell Significance Index: 217.5200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.9805
Cell Significance Index: 591.4900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 2.8689
Cell Significance Index: 160.9900 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 2.3490
Cell Significance Index: 60.3800 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 2.2567
Cell Significance Index: 15.2900 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 2.0147
Cell Significance Index: 30.3600 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.7796
Cell Significance Index: 123.0700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.5378
Cell Significance Index: 189.0900 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.4366
Cell Significance Index: 258.9700 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.2469
Cell Significance Index: 2347.8500 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.1650
Cell Significance Index: 54.3200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 1.0861
Cell Significance Index: 27.1500 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.0179
Cell Significance Index: 919.0700 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.9170
Cell Significance Index: 634.2000 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.9138
Cell Significance Index: 404.0200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.8184
Cell Significance Index: 164.1800 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.7831
Cell Significance Index: 55.3900 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.7548
Cell Significance Index: 82.1000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.7230
Cell Significance Index: 459.1900 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.6772
Cell Significance Index: 1042.5700 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.6386
Cell Significance Index: 9.1700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.6154
Cell Significance Index: 84.5100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.6075
Cell Significance Index: 826.0500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.4474
Cell Significance Index: 203.0600 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3841
Cell Significance Index: 23.0600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3724
Cell Significance Index: 10.7300 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3688
Cell Significance Index: 132.3000 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.2344
Cell Significance Index: 3.4600 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1720
Cell Significance Index: 27.9700 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.1710
Cell Significance Index: 10.5100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1688
Cell Significance Index: 311.3300 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0396
Cell Significance Index: 21.6300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1027
Cell Significance Index: -17.5300 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1029
Cell Significance Index: -2.9500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.1291
Cell Significance Index: -95.6500 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.1322
Cell Significance Index: -96.9200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.1454
Cell Significance Index: -14.3800 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1491
Cell Significance Index: -5.2400 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.1666
Cell Significance Index: -126.0900 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1841
Cell Significance Index: -114.9400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1895
Cell Significance Index: -106.8800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.3389
Cell Significance Index: -49.2600 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.3894
Cell Significance Index: -29.0200 - Cell Name: peg cell (CL4033014)
Fold Change: -0.4545
Cell Significance Index: -10.5000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.4683
Cell Significance Index: -134.7400 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.4930
Cell Significance Index: -50.3600 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.5434
Cell Significance Index: -114.4500 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.5460
Cell Significance Index: -69.9900 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.5806
Cell Significance Index: -75.0200 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: -0.6215
Cell Significance Index: -118.2800 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.7213
Cell Significance Index: -17.6000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.7773
Cell Significance Index: -40.4900 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.7812
Cell Significance Index: -11.5300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.7876
Cell Significance Index: -35.7000 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.7908
Cell Significance Index: -37.1700 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.8257
Cell Significance Index: -11.8800 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.9393
Cell Significance Index: -109.4600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.9604
Cell Significance Index: -110.0300 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.9653
Cell Significance Index: -16.1600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.0330
Cell Significance Index: -107.5600 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -1.1409
Cell Significance Index: -59.9000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -1.1763
Cell Significance Index: -138.7200 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -1.2928
Cell Significance Index: -147.5700 - Cell Name: adipocyte of breast (CL0002617)
Fold Change: -1.4366
Cell Significance Index: -18.0900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.4849
Cell Significance Index: -20.2600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.5330
Cell Significance Index: -93.9900 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.5677
Cell Significance Index: -124.1600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.8703
Cell Significance Index: -40.5200 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: -2.0721
Cell Significance Index: -15.0700 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -2.0883
Cell Significance Index: -108.4800 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -2.1136
Cell Significance Index: -69.2000 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -2.2107
Cell Significance Index: -142.6300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -2.2923
Cell Significance Index: -62.4000 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -2.4590
Cell Significance Index: -78.3200 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: -2.4773
Cell Significance Index: -21.9900 - Cell Name: glioblast (CL0000030)
Fold Change: -2.4986
Cell Significance Index: -15.6900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -2.5949
Cell Significance Index: -163.5500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -2.6095
Cell Significance Index: -83.5800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -2.6919
Cell Significance Index: -119.0700 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -2.8808
Cell Significance Index: -49.8100 - Cell Name: granulosa cell (CL0000501)
Fold Change: -2.9473
Cell Significance Index: -77.5000 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -2.9572
Cell Significance Index: -37.9200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2830633130
Symbol: NFIA_HUMAN
Name: Nuclear factor 1 A-type
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10718198
Title: Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10718198
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7590749
Title: Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH.
PubMed ID: 7590749
PubMed ID: 18220336
Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
PubMed ID: 18220336
DOI: 10.1021/pr0705441
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24462883
Title: An intragenic deletion of the NFIA gene in a patient with a hypoplastic corpus callosum, craniofacial abnormalities and urinary tract defects.
PubMed ID: 24462883
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 27081522
Title: Truncating mutation in NFIA causes brain malformation and urinary tract defects.
PubMed ID: 27081522
DOI: 10.1038/hgv.2015.7
PubMed ID: 31375868
Title: The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs.
PubMed ID: 31375868
Sequence Information:
- Length: 509
- Mass: 55944
- Checksum: 42090C6B8B229F87
- Sequence:
MYSPLCLTQD EFHPFIEALL PHVRAFAYTW FNLQARKRKY FKKHEKRMSK EEERAVKDEL LSEKPEVKQK WASRLLAKLR KDIRPEYRED FVLTVTGKKP PCCVLSNPDQ KGKMRRIDCL RQADKVWRLD LVMVILFKGI PLESTDGERL VKSPQCSNPG LCVQPHHIGV SVKELDLYLA YFVHAADSSQ SESPSQPSDA DIKDQPENGH LGFQDSFVTS GVFSVTELVR VSQTPIAAGT GPNFSLSDLE SSSYYSMSPG AMRRSLPSTS STSSTKRLKS VEDEMDSPGE EPFYTGQGRS PGSGSQSSGW HEVEPGMPSP TTLKKSEKSG FSSPSPSQTS SLGTAFTQHH RPVITGPRAS PHATPSTLHF PTSPIIQQPG PYFSHPAIRY HPQETLKEFV QLVCPDAGQQ AGQVGFLNPN GSSQGKVHNP FLPTPMLPPP PPPPMARPVP LPVPDTKPPT TSTEGGAASP TSPTYSTPST SPANRFVSVG PRDPSFVNIP QQTQSWYLG
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.