Details for: NFIA

Gene ID: 4774

Symbol: NFIA

Ensembl ID: ENSG00000162599

Description: nuclear factor I A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 859.2999
    Cell Significance Index: -133.6600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 598.9906
    Cell Significance Index: -151.9300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 314.6110
    Cell Significance Index: -148.5400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 282.2104
    Cell Significance Index: -114.6500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 269.8367
    Cell Significance Index: -138.8000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 221.8630
    Cell Significance Index: -148.8800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 122.5754
    Cell Significance Index: -151.1300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 119.9904
    Cell Significance Index: -114.5600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 53.5097
    Cell Significance Index: -143.3500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 46.9435
    Cell Significance Index: -102.7400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 39.1480
    Cell Significance Index: -154.4800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 8.1277
    Cell Significance Index: 158.6300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 7.6139
    Cell Significance Index: 130.4800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 5.9190
    Cell Significance Index: 165.4200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 4.8175
    Cell Significance Index: 102.9800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 4.7657
    Cell Significance Index: 365.7200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 3.9205
    Cell Significance Index: 66.0400
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 3.3082
    Cell Significance Index: 46.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 3.2350
    Cell Significance Index: 217.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.9805
    Cell Significance Index: 591.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.8689
    Cell Significance Index: 160.9900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.3490
    Cell Significance Index: 60.3800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.2567
    Cell Significance Index: 15.2900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 2.0147
    Cell Significance Index: 30.3600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.7796
    Cell Significance Index: 123.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.5378
    Cell Significance Index: 189.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.4366
    Cell Significance Index: 258.9700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.2469
    Cell Significance Index: 2347.8500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1650
    Cell Significance Index: 54.3200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.0861
    Cell Significance Index: 27.1500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0179
    Cell Significance Index: 919.0700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9170
    Cell Significance Index: 634.2000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9138
    Cell Significance Index: 404.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8184
    Cell Significance Index: 164.1800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7831
    Cell Significance Index: 55.3900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7548
    Cell Significance Index: 82.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.7230
    Cell Significance Index: 459.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.6772
    Cell Significance Index: 1042.5700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.6386
    Cell Significance Index: 9.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6154
    Cell Significance Index: 84.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.6075
    Cell Significance Index: 826.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.4474
    Cell Significance Index: 203.0600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3841
    Cell Significance Index: 23.0600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3724
    Cell Significance Index: 10.7300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3688
    Cell Significance Index: 132.3000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.2344
    Cell Significance Index: 3.4600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1720
    Cell Significance Index: 27.9700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1710
    Cell Significance Index: 10.5100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1688
    Cell Significance Index: 311.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0396
    Cell Significance Index: 21.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1027
    Cell Significance Index: -17.5300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1029
    Cell Significance Index: -2.9500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1291
    Cell Significance Index: -95.6500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.1322
    Cell Significance Index: -96.9200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1454
    Cell Significance Index: -14.3800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1491
    Cell Significance Index: -5.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1666
    Cell Significance Index: -126.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1841
    Cell Significance Index: -114.9400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1895
    Cell Significance Index: -106.8800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3389
    Cell Significance Index: -49.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3894
    Cell Significance Index: -29.0200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4545
    Cell Significance Index: -10.5000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4683
    Cell Significance Index: -134.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.4930
    Cell Significance Index: -50.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.5434
    Cell Significance Index: -114.4500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.5460
    Cell Significance Index: -69.9900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.5806
    Cell Significance Index: -75.0200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.6215
    Cell Significance Index: -118.2800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.7213
    Cell Significance Index: -17.6000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7773
    Cell Significance Index: -40.4900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.7812
    Cell Significance Index: -11.5300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.7876
    Cell Significance Index: -35.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.7908
    Cell Significance Index: -37.1700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.8257
    Cell Significance Index: -11.8800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.9393
    Cell Significance Index: -109.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.9604
    Cell Significance Index: -110.0300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.9653
    Cell Significance Index: -16.1600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.0330
    Cell Significance Index: -107.5600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.1409
    Cell Significance Index: -59.9000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -1.1763
    Cell Significance Index: -138.7200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.2928
    Cell Significance Index: -147.5700
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -1.4366
    Cell Significance Index: -18.0900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.4849
    Cell Significance Index: -20.2600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.5330
    Cell Significance Index: -93.9900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.5677
    Cell Significance Index: -124.1600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.8703
    Cell Significance Index: -40.5200
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -2.0721
    Cell Significance Index: -15.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -2.0883
    Cell Significance Index: -108.4800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -2.1136
    Cell Significance Index: -69.2000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -2.2107
    Cell Significance Index: -142.6300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -2.2923
    Cell Significance Index: -62.4000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -2.4590
    Cell Significance Index: -78.3200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -2.4773
    Cell Significance Index: -21.9900
  • Cell Name: glioblast (CL0000030)
    Fold Change: -2.4986
    Cell Significance Index: -15.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.5949
    Cell Significance Index: -163.5500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -2.6095
    Cell Significance Index: -83.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.6919
    Cell Significance Index: -119.0700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -2.8808
    Cell Significance Index: -49.8100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -2.9473
    Cell Significance Index: -77.5000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -2.9572
    Cell Significance Index: -37.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NFIA is a transcription factor that belongs to the NFI family of proteins. It is characterized by its ability to bind to specific DNA sequences, thereby regulating gene expression. NFIA is specifically expressed in neuron-associated cells, stellate neurons, mature astrocytes, granule cells, skeletal muscle fibroblasts, macroglial cells, and epithelial cells of the tracheobronchial tree and prostate. Its expression is highly conserved across vertebrates, suggesting its importance in evolution. **Pathways and Functions** NFIA is involved in various signaling pathways, including the BMP (Bone Morphogenetic Protein) signaling pathway, which regulates cell growth, differentiation, and patterning. NFIA also plays a critical role in chromatin remodeling, chromatin binding, and DNA replication. Its functions include: 1. **Positive regulation of transcription**: NFIA acts as a transcriptional activator by binding to specific DNA sequences and recruiting RNA polymerase II. 2. **Chromatin remodeling**: NFIA regulates chromatin structure and accessibility, thereby influencing gene expression. 3. **Cellular differentiation**: NFIA is involved in the differentiation of neuron-associated cells and epithelial cells. 4. **Wound response**: NFIA is activated in response to tissue injury, promoting the expression of genes involved in tissue repair and regeneration. **Clinical Significance** Dysregulation of NFIA has been implicated in various diseases, including: 1. **Cancer**: NFIA has been shown to be overexpressed in certain types of cancer, including prostate cancer and glioblastoma. 2. **Neurological disorders**: NFIA has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Cardiovascular disease**: NFIA has been shown to play a role in the development of cardiovascular disease, including atherosclerosis and heart failure. In conclusion, NFIA is a critical transcription factor that regulates gene expression in various cell types, including neurons and epithelial cells. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its functions and mechanisms of action. Further studies are needed to elucidate the role of NFIA in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 2830633130

Symbol: NFIA_HUMAN

Name: Nuclear factor 1 A-type

UniProtKB Accession Codes:

Q12857 B4DRJ3 B4DS53 F5H0R0 F8W8W3 Q8TA97 Q9H3X9 Q9P2A9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 Ensembl 4 ExpressionAtlas 1 GO 29 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 2 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10718198

Title: Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10718198

DOI: 10.1093/dnares/7.1.65

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7590749

Title: Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH.

PubMed ID: 7590749

DOI: 10.1006/geno.1995.1107

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24462883

Title: An intragenic deletion of the NFIA gene in a patient with a hypoplastic corpus callosum, craniofacial abnormalities and urinary tract defects.

PubMed ID: 24462883

DOI: 10.1016/j.ejmg.2013.12.011

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27081522

Title: Truncating mutation in NFIA causes brain malformation and urinary tract defects.

PubMed ID: 27081522

DOI: 10.1038/hgv.2015.7

PubMed ID: 31375868

Title: The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs.

PubMed ID: 31375868

DOI: 10.1007/s00018-019-03251-w

Sequence Information:

  • Length: 509
  • Mass: 55944
  • Checksum: 42090C6B8B229F87
  • Sequence:
    • MYSPLCLTQD EFHPFIEALL PHVRAFAYTW FNLQARKRKY FKKHEKRMSK EEERAVKDEL 
LSEKPEVKQK WASRLLAKLR KDIRPEYRED FVLTVTGKKP PCCVLSNPDQ KGKMRRIDCL 
RQADKVWRLD LVMVILFKGI PLESTDGERL VKSPQCSNPG LCVQPHHIGV SVKELDLYLA 
YFVHAADSSQ SESPSQPSDA DIKDQPENGH LGFQDSFVTS GVFSVTELVR VSQTPIAAGT 
GPNFSLSDLE SSSYYSMSPG AMRRSLPSTS STSSTKRLKS VEDEMDSPGE EPFYTGQGRS 
PGSGSQSSGW HEVEPGMPSP TTLKKSEKSG FSSPSPSQTS SLGTAFTQHH RPVITGPRAS 
PHATPSTLHF PTSPIIQQPG PYFSHPAIRY HPQETLKEFV QLVCPDAGQQ AGQVGFLNPN 
GSSQGKVHNP FLPTPMLPPP PPPPMARPVP LPVPDTKPPT TSTEGGAASP TSPTYSTPST 
SPANRFVSVG PRDPSFVNIP QQTQSWYLG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.