Details for: NFIA
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 73.08rCSI 100%PRS 69.22
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CSI 72.37rCSI 92.93%PRS 67.61
-
CSI 64.29rCSI 100%PRS 66.66
-
CSI 63.99rCSI 94.07%PRS 70.05
-
CSI 49.92rCSI 100%PRS 55.49
-
CSI 49.77rCSI 90.44%PRS 68.56
-
CSI 47.71rCSI 68.46%PRS 66.97
-
CSI 47.58rCSI 75.9%PRS 68.92
-
CSI 46.48rCSI 99.04%PRS 52
-
CSI 45.85rCSI 100%PRS 74.62
-
CSI 45.18rCSI 62.76%PRS 75.98
-
CSI 42.83rCSI 96.03%PRS 59.7
-
CSI 42.4rCSI 71.18%PRS 59
-
CSI 38.57rCSI 84.86%PRS 60.14
-
CSI 35.2rCSI 40.66%PRS 69.56
-
CSI 35.08rCSI 61.51%PRS 70.64
-
CSI 31.99rCSI 33.38%PRS 76.63
-
CSI 31.07rCSI 39.88%PRS 73.53
-
CSI 31.06rCSI 42.44%PRS 77.66
-
CSI 31rCSI 27.26%PRS 66.12
-
CSI 29.5rCSI 41.81%PRS 73.99
-
CSI 28.67rCSI 30.72%PRS 78.3
-
CSI 27.96rCSI 87.39%PRS 60.69
-
CSI 27.84rCSI 35.43%PRS 82.37
-
CSI 27.35rCSI 65.75%PRS 81.1
-
CSI 26.98rCSI 23.95%PRS 75.07
-
CSI 23.64rCSI 47.46%PRS 67.01
-
CSI 23.54rCSI 95.94%PRS 69.52
-
CSI 23.31rCSI 37.77%PRS 72.48
-
CSI 23.15rCSI 76.09%PRS 63.53
-
CSI 22.24rCSI 100%PRS 77.14
-
CSI 22.1rCSI 19.96%PRS 75.35
-
CSI 21.98rCSI 58.73%PRS 68.61
-
CSI 21.01rCSI 16.34%PRS 91.21
-
CSI 20.06rCSI 68.72%PRS 63.81
-
CSI 19.87rCSI 18.34%PRS 78.75
-
CSI 19.61rCSI 37.39%PRS 87.26
-
CSI 19.48rCSI 15.4%PRS 65.52
-
CSI 19.41rCSI 63.16%PRS 75
-
CSI 18.69rCSI 22.33%PRS 58.96
-
CSI 18.19rCSI 58.36%PRS 79.66
-
CSI 18.14rCSI 49.99%PRS 72.3
-
CSI 18.03rCSI 31.19%PRS 68.49
-
CSI 17.98rCSI 27.46%PRS 77.62
-
CSI 17.93rCSI 27.56%PRS 67.58
-
CSI 16.94rCSI 44.02%PRS 85.04
-
CSI 16.79rCSI 23.26%PRS 74.87
-
CSI 16.46rCSI 48.66%PRS 68.33
-
CSI 16.04rCSI 36.38%PRS 78.25
-
CSI 15.94rCSI 80.23%PRS 75
-
CSI 15.51rCSI 18.73%PRS 85.08
-
CSI 15.5rCSI 19.27%PRS 78.62
-
CSI 15.34rCSI 45.29%PRS 78.45
-
CSI 15.22rCSI 18.27%PRS 75
-
CSI 15.18rCSI 48.56%PRS 74.31
-
CSI 15.1rCSI 27.68%PRS 82.35
-
CSI 14.98rCSI 14.45%PRS 70.14
-
CSI 14.53rCSI 28.84%PRS 73.33
-
CSI 14.27rCSI 32.63%PRS 78.14
-
CSI 13.89rCSI 36.2%PRS 72.36
-
CSI 13.85rCSI 37.33%PRS 82.68
-
CSI 13.84rCSI 91.88%PRS 72.75
-
CSI 13.76rCSI 65.89%PRS 73.98
-
CSI 13.49rCSI 13.47%PRS 70.97
-
CSI 13.31rCSI 24.94%PRS 65.3
-
CSI 13.31rCSI 12.39%PRS 77.84
-
CSI 13.19rCSI 10.22%PRS 80.86
-
CSI 13.09rCSI 77.1%PRS 59.8
-
CSI 13.08rCSI 10.63%PRS 76.69
-
CSI 13.04rCSI 37.78%PRS 66.5
-
CSI 12.8rCSI 18.93%PRS 81.72
-
CSI 12.72rCSI 10.66%PRS 80.35
-
CSI 12.71rCSI 15.47%PRS 83.86
-
CSI 12.35rCSI 12.91%PRS 74.99
-
CSI 12.25rCSI 10.56%PRS 78.69
-
CSI 12.15rCSI 35.17%PRS 76.95
-
CSI 12.12rCSI 45.73%PRS 60.14
-
CSI 12.03rCSI 21.45%PRS 86.35
-
CSI 11.88rCSI 42.76%PRS 56.96
-
CSI 11.75rCSI 62.45%PRS 67.62
-
CSI 11.74rCSI 28.04%PRS 81.77
-
CSI 11.73rCSI 17.18%PRS 84.65
-
CSI 11.72rCSI 20.98%PRS 76.6
-
CSI 11.69rCSI 15.08%PRS 60.21
-
CSI 11.59rCSI 9.61%PRS 77.83
-
CSI 11.52rCSI 12.61%PRS 79.43
-
CSI 11.49rCSI 17.34%PRS 82.6
-
CSI 11.47rCSI 58.01%PRS 91.85
-
CSI 11.33rCSI 67.88%PRS 80.52
-
CSI 11.31rCSI 34.85%PRS 82.1
-
CSI 11.21rCSI 25.88%PRS 65.2
-
CSI 11.12rCSI 33.01%PRS 86.25
-
CSI 10.95rCSI 26.75%PRS 69.95
-
CSI 10.63rCSI 72.32%PRS 70.65
-
CSI 10.31rCSI 26.86%PRS 78.11
-
CSI 10.3rCSI 11.91%PRS 69.13
-
CSI 10.17rCSI 32.75%PRS 74.16
-
CSI 10.17rCSI 78.76%PRS 72.13
-
CSI 10.02rCSI 10.37%PRS 81.81
-
CSI 9.92rCSI 14.74%PRS 77.55
-
CSI 0.2rCSI 1.6%PRS 88.5%
-
CSI 0.2rCSI 3.1%PRS 84.8%
-
CSI 0.4rCSI 3.9%PRS 87.2%
-
CSI 0.5rCSI 2.6%PRS 87.9%
-
CSI 0.6rCSI 3.3%PRS 81.7%
-
CSI 0.6rCSI 3.0%PRS 85.3%
-
CSI 0.6rCSI 9.2%PRS 82.3%
-
CSI 0.6rCSI 15.5%PRS 86.9%
-
CSI 0.6rCSI 3.2%PRS 86.3%
-
CSI 0.8rCSI 14.7%PRS 85.9%
-
CSI 0.8rCSI 6.0%PRS 86.1%
-
CSI 0.9rCSI 15.1%PRS 88.4%
-
CSI 0.9rCSI 14.3%PRS 87.9%
-
CSI 1.0rCSI 4.1%PRS 86.0%
-
CSI 1.0rCSI 7.6%PRS 64.3%
-
CSI 1.0rCSI 7.5%PRS 68.7%
-
CSI 1.1rCSI 26.7%PRS 58.0%
-
CSI 1.1rCSI 2.7%PRS 64.1%
-
CSI 1.1rCSI 27.2%PRS 57.4%
-
CSI 1.2rCSI 8.9%PRS 79.4%
-
CSI 1.2rCSI 8.1%PRS 84.7%
-
CSI 1.2rCSI 6.0%PRS 85.4%
-
CSI 1.2rCSI 5.6%PRS 85.4%
-
CSI 1.4rCSI 29.3%PRS 68.4%
-
CSI 1.5rCSI 2.7%PRS 88.1%
-
CSI 1.5rCSI 8.0%PRS 84.4%
-
CSI 1.5rCSI 11.7%PRS 83.3%
-
CSI 1.5rCSI 6.7%PRS 65.8%
-
CSI 1.6rCSI 4.9%PRS 63.1%
-
CSI 1.6rCSI 9.4%PRS 83.7%
-
CSI 1.7rCSI 9.5%PRS 83.3%
-
CSI 1.7rCSI 4.9%PRS 90.3%
-
CSI 1.7rCSI 18.5%PRS 85.9%
-
CSI 1.7rCSI 3.3%PRS 88.7%
-
CSI 1.8rCSI 35.6%PRS 67.1%
-
CSI 1.8rCSI 5.1%PRS 84.4%
-
CSI 1.8rCSI 2.6%PRS 88.3%
-
CSI 1.9rCSI 19.6%PRS 73.9%
-
CSI 1.9rCSI 17.3%PRS 79.9%
-
CSI 1.9rCSI 2.9%PRS 86.2%
-
CSI 1.9rCSI 15.4%PRS 71.0%
-
CSI 1.9rCSI 8.5%PRS 87.2%
-
CSI 1.9rCSI 28.8%PRS 86.5%
-
CSI 1.9rCSI 3.8%PRS 86.8%
-
CSI 2.0rCSI 2.1%PRS 80.8%
-
CSI 2.0rCSI 5.8%PRS 84.9%
-
CSI 2.1rCSI 11.4%PRS 87.2%
-
CSI 2.1rCSI 2.2%PRS 74.5%
-
CSI 2.1rCSI 14.6%PRS 83.6%
-
CSI 2.1rCSI 10.9%PRS 69.8%
-
CSI 2.2rCSI 9.1%PRS 83.1%
-
CSI 2.2rCSI 8.6%PRS 92.5%
-
CSI 2.2rCSI 8.5%PRS 59.5%
-
CSI 2.3rCSI 2.1%PRS 89.2%
-
CSI 2.3rCSI 8.1%PRS 85.9%
-
CSI 2.4rCSI 5.7%PRS 82.3%
-
CSI 2.4rCSI 5.7%PRS 83.3%
-
CSI 2.4rCSI 5.1%PRS 84.2%
-
CSI 2.5rCSI 1.9%PRS 79.9%
-
CSI 2.5rCSI 27.3%PRS 83.3%
-
CSI 2.6rCSI 8.8%PRS 76.1%
-
CSI 2.6rCSI 6.7%PRS 72.6%
-
CSI 2.6rCSI 3.5%PRS 83.1%
-
CSI 2.6rCSI 23.4%PRS 86.0%
-
CSI 2.7rCSI 11.5%PRS 85.1%
-
CSI 2.7rCSI 12.5%PRS 69.7%
-
CSI 2.7rCSI 16.7%PRS 57.9%
-
CSI 2.7rCSI 6.8%PRS 76.7%
-
CSI 2.8rCSI 7.3%PRS 89.7%
-
CSI 2.8rCSI 17.9%PRS 83.1%
-
CSI 2.8rCSI 17.3%PRS 84.2%
-
CSI 2.9rCSI 7.4%PRS 76.6%
-
CSI 3.0rCSI 8.3%PRS 85.1%
-
CSI 3.0rCSI 22.5%PRS 68.8%
-
CSI 3.0rCSI 4.8%PRS 70.1%
-
CSI 3.1rCSI 13.5%PRS 77.7%
-
CSI 3.1rCSI 2.5%PRS 79.7%
-
CSI 3.1rCSI 7.9%PRS 70.6%
-
CSI 3.1rCSI 12.5%PRS 85.6%
-
CSI 3.2rCSI 7.5%PRS 78.2%
-
CSI 3.2rCSI 6.8%PRS 71.8%
-
CSI 3.2rCSI 3.8%PRS 79.1%
-
CSI 3.3rCSI 12.7%PRS 73.9%
-
CSI 3.4rCSI 78.5%PRS 90.1%
-
CSI 3.4rCSI 13.2%PRS 87.0%
-
CSI 3.4rCSI 29.7%PRS 72.6%
-
CSI 3.4rCSI 5.5%PRS 86.4%
-
CSI 3.5rCSI 15.9%PRS 82.2%
-
CSI 3.5rCSI 9.1%PRS 78.7%
-
CSI 3.7rCSI 6.9%PRS 85.7%
-
CSI 3.7rCSI 32.2%PRS 65.6%
-
CSI 3.7rCSI 17.5%PRS 88.9%
-
CSI 3.8rCSI 14.7%PRS 55.3%
-
CSI 3.8rCSI 19.8%PRS 79.0%
-
CSI 3.8rCSI 39.1%PRS 71.2%
-
CSI 4.0rCSI 24.0%PRS 88.9%
-
CSI 4.0rCSI 10.2%PRS 67.5%
-
CSI 4.0rCSI 5.2%PRS 80.9%
-
CSI 4.0rCSI 7.1%PRS 58.2%
-
CSI 4.1rCSI 44.2%PRS 86.3%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2830633130
Symbol: NFIA_HUMAN
Name: Nuclear factor 1 A-type
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10718198
Title: Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10718198
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7590749
Title: Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH.
PubMed ID: 7590749
PubMed ID: 18220336
Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
PubMed ID: 18220336
DOI: 10.1021/pr0705441
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24462883
Title: An intragenic deletion of the NFIA gene in a patient with a hypoplastic corpus callosum, craniofacial abnormalities and urinary tract defects.
PubMed ID: 24462883
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 27081522
Title: Truncating mutation in NFIA causes brain malformation and urinary tract defects.
PubMed ID: 27081522
DOI: 10.1038/hgv.2015.7
PubMed ID: 31375868
Title: The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs.
PubMed ID: 31375868
Sequence Information:
- Length: 509
- Mass: 55944
- Checksum: 42090C6B8B229F87
- Sequence:
MYSPLCLTQD EFHPFIEALL PHVRAFAYTW FNLQARKRKY FKKHEKRMSK EEERAVKDEL LSEKPEVKQK WASRLLAKLR KDIRPEYRED FVLTVTGKKP PCCVLSNPDQ KGKMRRIDCL RQADKVWRLD LVMVILFKGI PLESTDGERL VKSPQCSNPG LCVQPHHIGV SVKELDLYLA YFVHAADSSQ SESPSQPSDA DIKDQPENGH LGFQDSFVTS GVFSVTELVR VSQTPIAAGT GPNFSLSDLE SSSYYSMSPG AMRRSLPSTS STSSTKRLKS VEDEMDSPGE EPFYTGQGRS PGSGSQSSGW HEVEPGMPSP TTLKKSEKSG FSSPSPSQTS SLGTAFTQHH RPVITGPRAS PHATPSTLHF PTSPIIQQPG PYFSHPAIRY HPQETLKEFV QLVCPDAGQQ AGQVGFLNPN GSSQGKVHNP FLPTPMLPPP PPPPMARPVP LPVPDTKPPT TSTEGGAASP TSPTYSTPST SPANRFVSVG PRDPSFVNIP QQTQSWYLG