Details for: NFIA

Gene ID: 4774

Symbol: NFIA

Ensembl ID: ENSG00000162599

Description: nuclear factor I A

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 8.9
    Marker Score: 46,708
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 5.86
    Marker Score: 31,484
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 5.78
    Marker Score: 3,802
  • Cell Name: granule cell (CL0000120)
    Fold Change: 5.6
    Marker Score: 42,195
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 5.13
    Marker Score: 3,377
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 5.06
    Marker Score: 11,632
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 4.84
    Marker Score: 16,240
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 4.81
    Marker Score: 5,449
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 4.38
    Marker Score: 3,040
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 4.34
    Marker Score: 5,403
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 4.32
    Marker Score: 2,421
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 4.31
    Marker Score: 2,504
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 4.31
    Marker Score: 96,310
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 4.24
    Marker Score: 2,356
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 4.01
    Marker Score: 2,175
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 3.95
    Marker Score: 3,503
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 3.82
    Marker Score: 7,355
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 3.54
    Marker Score: 3,380
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 3.54
    Marker Score: 1,293
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 3.53
    Marker Score: 8,443
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 3.46
    Marker Score: 1,955
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 3.45
    Marker Score: 1,659
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 3.41
    Marker Score: 886
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.41
    Marker Score: 4,126
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 3.4
    Marker Score: 3,910
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.25
    Marker Score: 69,331
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 3.24
    Marker Score: 13,578
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 3.21
    Marker Score: 1,018
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 3.16
    Marker Score: 2,734
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.14
    Marker Score: 3,358
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 3.13
    Marker Score: 10,259
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 3.1
    Marker Score: 1,533
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.08
    Marker Score: 7,720
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 3.06
    Marker Score: 2,046
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 3.02
    Marker Score: 970
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.96
    Marker Score: 1,656
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.94
    Marker Score: 52,114
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.91
    Marker Score: 10,342
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.87
    Marker Score: 826
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.8
    Marker Score: 6,137
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.74
    Marker Score: 7,821
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.71
    Marker Score: 2,352
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.68
    Marker Score: 784
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.67
    Marker Score: 1,560
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.64
    Marker Score: 1,540
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.58
    Marker Score: 3,742
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.55
    Marker Score: 2,681
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.48
    Marker Score: 10,343
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.46
    Marker Score: 3,416
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.46
    Marker Score: 83,546
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.45
    Marker Score: 1,464
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.38
    Marker Score: 38,157
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.38
    Marker Score: 8,434
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.37
    Marker Score: 1,178
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.37
    Marker Score: 31,233
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.35
    Marker Score: 2,902
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.31
    Marker Score: 6,038
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.29
    Marker Score: 1,949
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 2.28
    Marker Score: 2,460
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 2.23
    Marker Score: 810
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 2.23
    Marker Score: 567
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.18
    Marker Score: 4,976
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.17
    Marker Score: 2,323
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.17
    Marker Score: 2,795
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.12
    Marker Score: 3,875
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.09
    Marker Score: 31,294
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.07
    Marker Score: 476
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 2.06
    Marker Score: 646
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.05
    Marker Score: 2,530
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.05
    Marker Score: 7,574
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.01
    Marker Score: 3,294
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.01
    Marker Score: 2,215
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.98
    Marker Score: 10,665
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.98
    Marker Score: 740
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.98
    Marker Score: 2,658
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.97
    Marker Score: 1,037
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.95
    Marker Score: 1,888
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.93
    Marker Score: 558
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.93
    Marker Score: 1,453
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.93
    Marker Score: 1,269
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.9
    Marker Score: 1,339
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.9
    Marker Score: 600
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.88
    Marker Score: 5,121
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.87
    Marker Score: 675
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.87
    Marker Score: 70,927
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.86
    Marker Score: 634
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.86
    Marker Score: 15,976
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.86
    Marker Score: 701
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.85
    Marker Score: 898
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.84
    Marker Score: 17,501
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.84
    Marker Score: 873
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.84
    Marker Score: 1,246
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.83
    Marker Score: 2,140
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.83
    Marker Score: 11,739
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.83
    Marker Score: 11,874
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.82
    Marker Score: 783
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.82
    Marker Score: 918
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.82
    Marker Score: 1,133
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.81
    Marker Score: 1,621
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.8
    Marker Score: 1,822

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NFIA is a transcription factor that belongs to the NFI family of proteins. It is characterized by its ability to bind to specific DNA sequences, thereby regulating gene expression. NFIA is specifically expressed in neuron-associated cells, stellate neurons, mature astrocytes, granule cells, skeletal muscle fibroblasts, macroglial cells, and epithelial cells of the tracheobronchial tree and prostate. Its expression is highly conserved across vertebrates, suggesting its importance in evolution. **Pathways and Functions** NFIA is involved in various signaling pathways, including the BMP (Bone Morphogenetic Protein) signaling pathway, which regulates cell growth, differentiation, and patterning. NFIA also plays a critical role in chromatin remodeling, chromatin binding, and DNA replication. Its functions include: 1. **Positive regulation of transcription**: NFIA acts as a transcriptional activator by binding to specific DNA sequences and recruiting RNA polymerase II. 2. **Chromatin remodeling**: NFIA regulates chromatin structure and accessibility, thereby influencing gene expression. 3. **Cellular differentiation**: NFIA is involved in the differentiation of neuron-associated cells and epithelial cells. 4. **Wound response**: NFIA is activated in response to tissue injury, promoting the expression of genes involved in tissue repair and regeneration. **Clinical Significance** Dysregulation of NFIA has been implicated in various diseases, including: 1. **Cancer**: NFIA has been shown to be overexpressed in certain types of cancer, including prostate cancer and glioblastoma. 2. **Neurological disorders**: NFIA has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Cardiovascular disease**: NFIA has been shown to play a role in the development of cardiovascular disease, including atherosclerosis and heart failure. In conclusion, NFIA is a critical transcription factor that regulates gene expression in various cell types, including neurons and epithelial cells. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its functions and mechanisms of action. Further studies are needed to elucidate the role of NFIA in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 2830633130

Symbol: NFIA_HUMAN

Name: Nuclear factor 1 A-type

UniProtKB Accession Codes:

Q12857 B4DRJ3 B4DS53 F5H0R0 F8W8W3 Q8TA97 Q9H3X9 Q9P2A9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 29 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 2 RefSeq 4 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10718198

Title: Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10718198

DOI: 10.1093/dnares/7.1.65

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7590749

Title: Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH.

PubMed ID: 7590749

DOI: 10.1006/geno.1995.1107

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24462883

Title: An intragenic deletion of the NFIA gene in a patient with a hypoplastic corpus callosum, craniofacial abnormalities and urinary tract defects.

PubMed ID: 24462883

DOI: 10.1016/j.ejmg.2013.12.011

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27081522

Title: Truncating mutation in NFIA causes brain malformation and urinary tract defects.

PubMed ID: 27081522

DOI: 10.1038/hgv.2015.7

PubMed ID: 31375868

Title: The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs.

PubMed ID: 31375868

DOI: 10.1007/s00018-019-03251-w

Sequence Information:

  • Length: 509
  • Mass: 55944
  • Checksum: 42090C6B8B229F87
  • Sequence:
    • MYSPLCLTQD EFHPFIEALL PHVRAFAYTW FNLQARKRKY FKKHEKRMSK EEERAVKDEL 
LSEKPEVKQK WASRLLAKLR KDIRPEYRED FVLTVTGKKP PCCVLSNPDQ KGKMRRIDCL 
RQADKVWRLD LVMVILFKGI PLESTDGERL VKSPQCSNPG LCVQPHHIGV SVKELDLYLA 
YFVHAADSSQ SESPSQPSDA DIKDQPENGH LGFQDSFVTS GVFSVTELVR VSQTPIAAGT 
GPNFSLSDLE SSSYYSMSPG AMRRSLPSTS STSSTKRLKS VEDEMDSPGE EPFYTGQGRS 
PGSGSQSSGW HEVEPGMPSP TTLKKSEKSG FSSPSPSQTS SLGTAFTQHH RPVITGPRAS 
PHATPSTLHF PTSPIIQQPG PYFSHPAIRY HPQETLKEFV QLVCPDAGQQ AGQVGFLNPN 
GSSQGKVHNP FLPTPMLPPP PPPPMARPVP LPVPDTKPPT TSTEGGAASP TSPTYSTPST 
SPANRFVSVG PRDPSFVNIP QQTQSWYLG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.