Details for: PDLIM3

Gene ID: 27295

Symbol: PDLIM3

Ensembl ID: ENSG00000154553

Description: PDZ and LIM domain 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 90.9218
    Cell Significance Index: -37.4600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 70.2148
    Cell Significance Index: -33.1500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.7931
    Cell Significance Index: -27.4900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 18.2988
    Cell Significance Index: 446.4800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 18.1981
    Cell Significance Index: 293.6300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.5371
    Cell Significance Index: -33.5900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 6.5377
    Cell Significance Index: 168.0500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 5.0813
    Cell Significance Index: 55.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 3.5332
    Cell Significance Index: 271.1300
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.0432
    Cell Significance Index: 31.7700
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 1.9904
    Cell Significance Index: 9.1900
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.7731
    Cell Significance Index: 9.3300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.1129
    Cell Significance Index: 16.4300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0858
    Cell Significance Index: 140.2800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.9833
    Cell Significance Index: 102.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.9373
    Cell Significance Index: 69.8600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.5630
    Cell Significance Index: 1059.9900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.4941
    Cell Significance Index: 224.2700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3886
    Cell Significance Index: 24.4900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3807
    Cell Significance Index: 17.7500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.3605
    Cell Significance Index: 6.3700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2997
    Cell Significance Index: 8.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2273
    Cell Significance Index: 10.6900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.1602
    Cell Significance Index: 2.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1163
    Cell Significance Index: 13.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1120
    Cell Significance Index: 172.4100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0952
    Cell Significance Index: 0.8000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0898
    Cell Significance Index: 39.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0891
    Cell Significance Index: 56.6000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0789
    Cell Significance Index: 54.5500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0705
    Cell Significance Index: 1.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0346
    Cell Significance Index: 47.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0192
    Cell Significance Index: 35.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0163
    Cell Significance Index: -2.7900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0165
    Cell Significance Index: -12.2400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0301
    Cell Significance Index: -18.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0332
    Cell Significance Index: -18.7500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0382
    Cell Significance Index: -28.9400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0406
    Cell Significance Index: -22.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0424
    Cell Significance Index: -31.1000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0574
    Cell Significance Index: -0.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0592
    Cell Significance Index: -8.6000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0665
    Cell Significance Index: -8.5300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0722
    Cell Significance Index: -0.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0779
    Cell Significance Index: -27.9400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0877
    Cell Significance Index: -17.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0976
    Cell Significance Index: -17.6000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1092
    Cell Significance Index: -22.9900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1160
    Cell Significance Index: -33.3700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1257
    Cell Significance Index: -8.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1387
    Cell Significance Index: -27.5200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1438
    Cell Significance Index: -19.7500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1729
    Cell Significance Index: -19.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1916
    Cell Significance Index: -23.5600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1961
    Cell Significance Index: -31.9000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2497
    Cell Significance Index: -12.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2554
    Cell Significance Index: -26.0900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2623
    Cell Significance Index: -5.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2717
    Cell Significance Index: -31.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2836
    Cell Significance Index: -33.4500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3220
    Cell Significance Index: -9.0000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3440
    Cell Significance Index: -7.2000
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.3567
    Cell Significance Index: -2.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3756
    Cell Significance Index: -21.0800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3830
    Cell Significance Index: -23.5400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4371
    Cell Significance Index: -17.9100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4396
    Cell Significance Index: -5.2400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.4812
    Cell Significance Index: -28.8900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4824
    Cell Significance Index: -25.1300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5051
    Cell Significance Index: -33.9600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.5071
    Cell Significance Index: -6.5300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5528
    Cell Significance Index: -19.2100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5759
    Cell Significance Index: -9.8700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.5833
    Cell Significance Index: -7.4800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.5915
    Cell Significance Index: -3.5100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6210
    Cell Significance Index: -38.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6748
    Cell Significance Index: -35.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7030
    Cell Significance Index: -36.5200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.7412
    Cell Significance Index: -10.6600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.7422
    Cell Significance Index: -33.6400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7490
    Cell Significance Index: -26.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7978
    Cell Significance Index: -35.2900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8041
    Cell Significance Index: -26.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.8201
    Cell Significance Index: -17.4700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8447
    Cell Significance Index: -31.0100
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.9138
    Cell Significance Index: -13.6700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.9462
    Cell Significance Index: -35.8300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.9902
    Cell Significance Index: -17.1200
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -1.0197
    Cell Significance Index: -9.7600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.0393
    Cell Significance Index: -27.7500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.0564
    Cell Significance Index: -33.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.0614
    Cell Significance Index: -28.8900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.1008
    Cell Significance Index: -35.0600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -1.1287
    Cell Significance Index: -35.7000
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -1.1369
    Cell Significance Index: -15.7200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.1486
    Cell Significance Index: -33.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.1732
    Cell Significance Index: -30.8500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.1901
    Cell Significance Index: -26.0600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -1.1942
    Cell Significance Index: -29.7800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -1.1976
    Cell Significance Index: -29.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PDLIM3 is a 33-kDa protein that contains two distinct domains: a PDZ (Postsynaptic Density-Zone) domain and a LIM (Lin-11, Islet-1, and Mec-3) domain. The PDZ domain is responsible for protein-protein interactions, while the LIM domain mediates interactions with actin filaments. PDLIM3 is expressed in various tissues, including skeletal muscle, smooth muscle, cardiac muscle, and epithelial cells, highlighting its widespread cellular distribution. **Pathways and Functions:** PDLIM3 is involved in several key cellular processes, including: 1. **Actin Cytoskeleton Organization:** PDLIM3 interacts with actin filaments and regulates their dynamics, influencing cell shape, motility, and intracellular signaling. 2. **Adherens Junctions:** PDLIM3 interacts with cadherins and other adhesion molecules, maintaining the integrity of cell-cell contacts and tissue architecture. 3. **Cell Signaling:** PDLIM3 serves as a scaffold for signaling proteins, modulating the activity of various receptors and kinases. 4. **Muscle Development and Structure:** PDLIM3 is essential for the development and maintenance of muscle structure, including the organization of sarcomeres and the regulation of muscle contraction. **Clinical Significance:** Dysregulation of PDLIM3 has been implicated in various diseases, including: 1. **Cardiovascular Disease:** Mutations in PDLIM3 have been associated with hypertrophic cardiomyopathy and arrhythmias. 2. **Cancer:** PDLIM3 is overexpressed in several types of cancer, including breast, lung, and colon cancer, and is associated with tumor progression and metastasis. 3. **Muscular Disorders:** PDLIM3 mutations have been linked to muscular dystrophy and other muscle disorders. 4. **Neurological Disorders:** PDLIM3 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. In conclusion, PDLIM3 is a critical regulator of actin cytoskeleton organization and cellular function, with far-reaching implications for human health and disease. Further research is needed to fully elucidate the mechanisms by which PDLIM3 regulates cellular processes and to develop therapeutic strategies for the treatment of PDLIM3-related diseases.

Genular Protein ID: 3139885055

Symbol: PDLI3_HUMAN

Name: PDZ and LIM domain protein 3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9334352

Title: Actinin-associated LIM protein: identification of a domain interaction between PDZ and spectrin-like repeat motifs.

PubMed ID: 9334352

DOI: 10.1083/jcb.139.2.507

PubMed ID: 10063829

Title: Exclusion of muscle specific actinin-associated LIM protein (ALP) gene from 4q35 facioscapulohumeral muscular dystrophy (FSHD) candidate genes.

PubMed ID: 10063829

DOI: 10.1016/s0960-8966(98)00087-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 364
  • Mass: 39232
  • Checksum: 083802DF22D7A237
  • Sequence:
  • MPQTVILPGP APWGFRLSGG IDFNQPLVIT RITPGSKAAA ANLCPGDVIL AIDGFGTESM 
    THADAQDRIK AAAHQLCLKI DRGETHLWSP QVSEDGKAHP FKINLESEPQ DGNYFEHKHN 
    IRPKPFVIPG RSSGCSTPSG IDCGSGRSTP SSVSTVSTIC PGDLKVAAKL APNIPLEMEL 
    PGVKIVHAQF NTPMQLYSDD NIMETLQGQV STALGETPLM SEPTASVPPE SDVYRMLHDN 
    RNEPTQPRQS GSFRVLQGMV DDGSDDRPAG TRSVRAPVTK VHGGSGGAQR MPLCDKCGSG 
    IVGAVVKARD KYRHPECFVC ADCNLNLKQK GYFFIEGELY CETHARARTK PPEGYDTVTL 
    YPKA

Genular Protein ID: 662694644

Symbol: A0A087WYF8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 276
  • Mass: 30157
  • Checksum: 2282B2253EB8934B
  • Sequence:
  • MPQTVILPGP APWGFRLSGG IDFNQPLVIT RITPGSKAAA ANLCPGDVIL AIDGFGTESM 
    THADAQDRIK AAAHQLCLKI DRGETHLWSP QVSEDGKAHP FKINLESEPQ DGNYFEHKHN 
    IRPKPFVIPG RSSEPTASVP PESDVYRMLH DNRNEPTQPR QSGSFRVLQG MVDDGSDDRP 
    AGTRSVRAPV TKVHGGSGGA QRMPLCDKCG SGIVGAVVKA RDKYRHPECF VCADCNLNLK 
    QKGYFFIEGE LYCETHARAR TKPPEGYDTV TLYPKA

Genular Protein ID: 1725030934

Symbol: A0A2U3TZH4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 197
  • Mass: 21755
  • Checksum: 6B42EAB52211710B
  • Sequence:
  • MPQTVILPGP APWGFRLSGG IDFNQPLVIT RDGNYFEHKH NIRPKPFVIP GRSSEPTASV 
    PPESDVYRML HDNRNEPTQP RQSGSFRVLQ GMVDDGSDDR PAGTRSVRAP VTKVHGGSGG 
    AQRMPLCDKC GSGIVGAVVK ARDKYRHPEC FVCADCNLNL KQKGYFFIEG ELYCETHARA 
    RTKPPEGYDT VTLYPKA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.