Details for: NNAT

Gene ID: 4826

Symbol: NNAT

Ensembl ID: ENSG00000053438

Description: neuronatin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 174.7723
    Cell Significance Index: -27.1900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 107.4343
    Cell Significance Index: -27.2500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 62.9934
    Cell Significance Index: -25.9500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 49.6976
    Cell Significance Index: -20.1900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 45.9626
    Cell Significance Index: -21.7000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.2099
    Cell Significance Index: -20.2500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 14.9558
    Cell Significance Index: 246.4500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 11.8417
    Cell Significance Index: 128.7400
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 7.4787
    Cell Significance Index: 42.5100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 6.2867
    Cell Significance Index: 218.4600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 3.4748
    Cell Significance Index: 213.5800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.3416
    Cell Significance Index: 73.1700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.8880
    Cell Significance Index: 60.4500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.4072
    Cell Significance Index: 57.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.6074
    Cell Significance Index: 90.2000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.5770
    Cell Significance Index: 111.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.4824
    Cell Significance Index: 65.5700
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.4647
    Cell Significance Index: 7.7100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.2491
    Cell Significance Index: 47.3000
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: 1.0175
    Cell Significance Index: 9.2500
  • Cell Name: glioblast (CL0000030)
    Fold Change: 1.0160
    Cell Significance Index: 6.3800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.8421
    Cell Significance Index: 24.0300
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.7604
    Cell Significance Index: 5.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6925
    Cell Significance Index: 36.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6603
    Cell Significance Index: 132.4500
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.6542
    Cell Significance Index: 3.8400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.6147
    Cell Significance Index: 13.1400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.5928
    Cell Significance Index: 8.7500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3723
    Cell Significance Index: 133.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2255
    Cell Significance Index: 64.8700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1622
    Cell Significance Index: 8.4500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1136
    Cell Significance Index: 5.9000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1095
    Cell Significance Index: 6.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0937
    Cell Significance Index: 6.3000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0834
    Cell Significance Index: 36.8800
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.0721
    Cell Significance Index: 0.5600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0463
    Cell Significance Index: 0.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0258
    Cell Significance Index: 4.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0009
    Cell Significance Index: 0.1100
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0134
    Cell Significance Index: -25.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0156
    Cell Significance Index: -3.1000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0158
    Cell Significance Index: -0.2700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0201
    Cell Significance Index: -37.1400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0209
    Cell Significance Index: -0.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0249
    Cell Significance Index: -38.3000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0290
    Cell Significance Index: -39.3700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0329
    Cell Significance Index: -24.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0344
    Cell Significance Index: -26.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0364
    Cell Significance Index: -23.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0401
    Cell Significance Index: -29.6900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0413
    Cell Significance Index: -23.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0455
    Cell Significance Index: -28.4400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0480
    Cell Significance Index: -1.5700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0516
    Cell Significance Index: -28.1700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0549
    Cell Significance Index: -24.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0686
    Cell Significance Index: -8.8000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1062
    Cell Significance Index: -0.6300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1215
    Cell Significance Index: -3.8700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1239
    Cell Significance Index: -1.3500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1297
    Cell Significance Index: -17.8100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1369
    Cell Significance Index: -3.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1416
    Cell Significance Index: -29.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1507
    Cell Significance Index: -21.9000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1664
    Cell Significance Index: -21.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1712
    Cell Significance Index: -29.2300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1985
    Cell Significance Index: -23.1300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2089
    Cell Significance Index: -5.0600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2117
    Cell Significance Index: -2.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2307
    Cell Significance Index: -26.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2384
    Cell Significance Index: -24.3500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2692
    Cell Significance Index: -28.0300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2734
    Cell Significance Index: -7.6400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2867
    Cell Significance Index: -21.3700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3027
    Cell Significance Index: -7.9600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3161
    Cell Significance Index: -6.2500
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.3191
    Cell Significance Index: -2.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3270
    Cell Significance Index: -38.5600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.3281
    Cell Significance Index: -2.6200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.3286
    Cell Significance Index: -3.1200
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.3470
    Cell Significance Index: -2.8700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3492
    Cell Significance Index: -26.8000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3528
    Cell Significance Index: -10.3900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3721
    Cell Significance Index: -9.2800
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.3793
    Cell Significance Index: -3.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3865
    Cell Significance Index: -17.5200
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.3884
    Cell Significance Index: -4.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3971
    Cell Significance Index: -25.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4303
    Cell Significance Index: -26.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4345
    Cell Significance Index: -20.4200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4396
    Cell Significance Index: -15.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5817
    Cell Significance Index: -27.1200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5929
    Cell Significance Index: -14.7900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6118
    Cell Significance Index: -12.9900
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.6278
    Cell Significance Index: -6.5400
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.6286
    Cell Significance Index: -6.2200
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.6629
    Cell Significance Index: -4.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6657
    Cell Significance Index: -21.3200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.6883
    Cell Significance Index: -5.8500
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.7261
    Cell Significance Index: -7.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular expression:** NNAT is widely expressed in various cell types, including neuronal brush cells, Purkinje cells, kidney interstitial cells, and peripheral nervous system neurons. 2. **Protein structure:** The NNAT protein consists of 100 amino acids, with a molecular weight of approximately 11 kDa. 3. **Functionality:** NNAT has been implicated in positive regulation of insulin secretion, protein lipoylation, and brain development. 4. **Pathway involvement:** NNAT is involved in several signaling pathways, including those related to insulin secretion, protein lipoylation, and cell growth. **Pathways and Functions:** 1. **Positive regulation of insulin secretion:** NNAT has been shown to enhance insulin secretion in pancreatic beta cells, suggesting a potential role in glucose metabolism and diabetes. 2. **Protein lipoylation:** NNAT is involved in the lipoylation of proteins, a post-translational modification that plays a crucial role in protein function and stability. 3. **Brain development:** NNAT is expressed in the developing brain and has been implicated in neuronal differentiation and survival. 4. **Cell growth and survival:** NNAT may also regulate cell growth and survival through its involvement in signaling pathways related to cell proliferation and apoptosis. **Clinical Significance:** 1. **Neurological disorders:** NNAT has been linked to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. 2. **Diabetes:** NNAT's role in insulin secretion regulation suggests that it may be involved in the pathogenesis of diabetes and related metabolic disorders. 3. **Cancer:** NNAT's involvement in cell growth and survival pathways may also contribute to cancer development and progression. 4. **Neuroinflammatory diseases:** NNAT's expression in immune cells and its involvement in inflammatory signaling pathways suggest that it may play a role in neuroinflammatory diseases, such as multiple sclerosis and Alzheimer's disease. **Conclusion:** In conclusion, NNAT is a multifunctional protein with a wide range of cellular and physiological functions. Its involvement in insulin secretion regulation, protein lipoylation, and brain development highlights its importance in maintaining cellular homeostasis. The clinical significance of NNAT in various diseases, including neurological disorders, diabetes, cancer, and neuroinflammatory diseases, underscores the need for further research into its role in human health and disease.

Genular Protein ID: 4114580341

Symbol: NNAT_HUMAN

Name: Neuronatin

UniProtKB Accession Codes:

Q16517 B2R558 E1P5V6 Q16596 Q5U0N3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 2 ExpressionAtlas 1 GO 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 3 SMR 1 STRING 1 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8813377

Title: Cloning of human neuronatin gene and its localization to chromosome-20q 11.2-12: the deduced protein is a novel 'proteolipid'.

PubMed ID: 8813377

DOI: 10.1016/0006-8993(96)00167-9

PubMed ID: 8660979

Title: Structure and organization of the human neuronatin gene.

PubMed ID: 8660979

DOI: 10.1006/geno.1996.0195

PubMed ID: 9356927

Title: cDNA cloning and mRNA expression analysis of the human neuronatin. High level expression in human pituitary gland and pituitary adenomas.

PubMed ID: 9356927

DOI: 10.1007/bf02789395

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 81
  • Mass: 9237
  • Checksum: 067086C7663E3D20
  • Sequence:
    • MAAVAAASAE LLIIGWYIFR VLLQVFLECC IYWVGFAFRN PPGTQPIARS EVFRYSLQKL 
AYTVSRTGRQ VLGERRQRAP N

Genular Protein ID: 2160105384

Symbol: A0A3B3ITN5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A3B3ITN5

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 2 GeneTree 1 HGNC 1 InterPro 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 125
  • Mass: 13390
  • Checksum: EDF2EA732A64B9BB
  • Sequence:
    • MAAVAAASAE LLIIGWYIFR VLLQVFLECC IYWVGFAFRN PPGTQPIARS VQVLPAEAGI 
HGVADRAAGV GGAQAASPQL RPQLPALGGR IIRCSCASRP AREPVPRRNV GSPVFPRQRS 
TWQGQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.