Details for: IGF2

Gene ID: 3481

Symbol: IGF2

Ensembl ID: ENSG00000167244

Description: insulin like growth factor 2

Associated with

  • Hemostasis
    (R-HSA-109582)
  • Igf1r signaling cascade
    (R-HSA-2428924)
  • Irs-related events triggered by igf1r
    (R-HSA-2428928)
  • Metabolism of proteins
    (R-HSA-392499)
  • Platelet activation, signaling and aggregation
    (R-HSA-76002)
  • Platelet degranulation
    (R-HSA-114608)
  • Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
    (R-HSA-381426)
  • Response to elevated platelet cytosolic ca2+
    (R-HSA-76005)
  • Shc-related events triggered by igf1r
    (R-HSA-2428933)
  • Signaling by receptor tyrosine kinases
    (R-HSA-9006934)
  • Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
    (R-HSA-2404192)
  • Signal transduction
    (R-HSA-162582)
  • Animal organ morphogenesis
    (GO:0009887)
  • Embryonic placenta development
    (GO:0001892)
  • Embryonic placenta morphogenesis
    (GO:0060669)
  • Exocrine pancreas development
    (GO:0031017)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Genomic imprinting
    (GO:0071514)
  • Glucose metabolic process
    (GO:0006006)
  • Growth factor activity
    (GO:0008083)
  • Hormone activity
    (GO:0005179)
  • Insulin-like growth factor receptor binding
    (GO:0005159)
  • Insulin-like growth factor receptor signaling pathway
    (GO:0048009)
  • Insulin receptor binding
    (GO:0005158)
  • Insulin receptor signaling pathway
    (GO:0008286)
  • Integrin binding
    (GO:0005178)
  • In utero embryonic development
    (GO:0001701)
  • Negative regulation of muscle cell differentiation
    (GO:0051148)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Osteoblast differentiation
    (GO:0001649)
  • Platelet alpha granule lumen
    (GO:0031093)
  • Positive regulation of activated t cell proliferation
    (GO:0042104)
  • Positive regulation of cell division
    (GO:0051781)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of glycogen biosynthetic process
    (GO:0045725)
  • Positive regulation of insulin receptor signaling pathway
    (GO:0046628)
  • Positive regulation of mapk cascade
    (GO:0043410)
  • Positive regulation of mitotic nuclear division
    (GO:0045840)
  • Positive regulation of multicellular organism growth
    (GO:0040018)
  • Positive regulation of organ growth
    (GO:0046622)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of skeletal muscle tissue growth
    (GO:0048633)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of vascular endothelial cell proliferation
    (GO:1905564)
  • Protein binding
    (GO:0005515)
  • Protein serine/threonine kinase activator activity
    (GO:0043539)
  • Receptor ligand activity
    (GO:0048018)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of muscle cell differentiation
    (GO:0051147)
  • Striated muscle cell differentiation
    (GO:0051146)
  • Transmembrane receptor protein tyrosine kinase activator activity
    (GO:0030297)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 45.1931
    Cell Significance Index: -18.3600
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 22.6769
    Cell Significance Index: 130.5900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 21.0253
    Cell Significance Index: 354.1700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.1779
    Cell Significance Index: -18.3100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 18.9214
    Cell Significance Index: 242.3200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 15.0924
    Cell Significance Index: 404.4100
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 11.7994
    Cell Significance Index: 58.8700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 8.7722
    Cell Significance Index: 304.8300
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 6.1375
    Cell Significance Index: 29.8500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 5.8460
    Cell Significance Index: 304.5100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 5.6433
    Cell Significance Index: 61.3500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.1305
    Cell Significance Index: 25.0000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.3481
    Cell Significance Index: 49.1500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.3009
    Cell Significance Index: 8.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9099
    Cell Significance Index: 496.9100
  • Cell Name: obsolete somatic cell (CL0002371)
    Fold Change: 0.7077
    Cell Significance Index: 5.3600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.6534
    Cell Significance Index: 4.0600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5518
    Cell Significance Index: 10.7700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3087
    Cell Significance Index: 8.8500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.2898
    Cell Significance Index: 4.8500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2637
    Cell Significance Index: 4.0800
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.2252
    Cell Significance Index: 1.0400
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.2223
    Cell Significance Index: 1.1700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1802
    Cell Significance Index: 23.1100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1777
    Cell Significance Index: 1.8400
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.1652
    Cell Significance Index: 0.9700
  • Cell Name: myoblast (CL0000056)
    Fold Change: 0.1130
    Cell Significance Index: 1.1100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0848
    Cell Significance Index: 11.6400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0296
    Cell Significance Index: 0.7900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0228
    Cell Significance Index: 0.9900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0043
    Cell Significance Index: 0.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0287
    Cell Significance Index: -21.2600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0314
    Cell Significance Index: -23.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0315
    Cell Significance Index: -17.7600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0446
    Cell Significance Index: -27.8400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0507
    Cell Significance Index: -1.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0711
    Cell Significance Index: -20.4600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0725
    Cell Significance Index: -26.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0757
    Cell Significance Index: -15.9500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0884
    Cell Significance Index: -15.9400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0896
    Cell Significance Index: -1.9200
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: -0.1047
    Cell Significance Index: -0.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1055
    Cell Significance Index: -21.1700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1125
    Cell Significance Index: -1.6400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1168
    Cell Significance Index: -3.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1286
    Cell Significance Index: -21.9600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1404
    Cell Significance Index: -3.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1467
    Cell Significance Index: -18.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1476
    Cell Significance Index: -16.9100
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.1600
    Cell Significance Index: -0.9800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1639
    Cell Significance Index: -1.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1710
    Cell Significance Index: -19.9300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1714
    Cell Significance Index: -4.4100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1734
    Cell Significance Index: -2.5600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1781
    Cell Significance Index: -25.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1831
    Cell Significance Index: -18.7000
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1979
    Cell Significance Index: -1.8800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2012
    Cell Significance Index: -1.7100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2294
    Cell Significance Index: -3.6400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2658
    Cell Significance Index: -7.8300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3277
    Cell Significance Index: -20.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3440
    Cell Significance Index: -26.4000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3633
    Cell Significance Index: -6.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3701
    Cell Significance Index: -22.6900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3736
    Cell Significance Index: -10.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3936
    Cell Significance Index: -18.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4595
    Cell Significance Index: -23.8700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4600
    Cell Significance Index: -25.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5137
    Cell Significance Index: -26.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5147
    Cell Significance Index: -24.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.5218
    Cell Significance Index: -23.6500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.5504
    Cell Significance Index: -7.7200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5617
    Cell Significance Index: -4.5800
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.6355
    Cell Significance Index: -3.0400
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.6367
    Cell Significance Index: -9.5300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.6420
    Cell Significance Index: -10.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.6856
    Cell Significance Index: -24.0900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7115
    Cell Significance Index: -26.1200
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.7156
    Cell Significance Index: -4.4800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.7239
    Cell Significance Index: -9.6500
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.7256
    Cell Significance Index: -8.4400
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: -0.7308
    Cell Significance Index: -1.6100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.7357
    Cell Significance Index: -23.2700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7418
    Cell Significance Index: -25.9900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.7451
    Cell Significance Index: -18.5800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.7638
    Cell Significance Index: -22.4300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7857
    Cell Significance Index: -25.7300
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.7895
    Cell Significance Index: -11.2300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8046
    Cell Significance Index: -25.6300
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.8187
    Cell Significance Index: -11.3200
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.8190
    Cell Significance Index: -8.9400
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.8458
    Cell Significance Index: -14.5300
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.8646
    Cell Significance Index: -9.5500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.8647
    Cell Significance Index: -22.0300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.8836
    Cell Significance Index: -22.0700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8913
    Cell Significance Index: -12.1600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.9176
    Cell Significance Index: -13.1400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.9407
    Cell Significance Index: -22.5600
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.9498
    Cell Significance Index: -10.2700
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.9678
    Cell Significance Index: -9.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IGF2 is characterized by its unique expression profile, which is primarily restricted to the placenta and fetal tissues during embryonic development. It is also highly expressed in certain cell types, such as mesangial cells, hepatoblasts, and skeletal muscle cells. IGF2 is a non-coding gene, meaning that it does not encode a protein that can be translated into a protein product. Instead, it regulates gene expression through its binding to a specific RNA-binding protein, which modulates the translation of target mRNAs. **Pathways and Functions** IGF2 is involved in several key signaling pathways that regulate cell growth, differentiation, and survival. These pathways include: 1. **IGF1R signaling cascade**: IGF2 binds to the IGF1 receptor (IGF1R), which activates a signaling cascade that regulates cell growth, differentiation, and survival. 2. **Insulin-like growth factor receptor signaling pathway**: IGF2 also binds to the insulin receptor (IR), which activates a signaling cascade that regulates glucose metabolism and insulin sensitivity. 3. **Growth factor activity**: IGF2 is a growth factor that regulates cell growth and differentiation by binding to its receptor, which activates a signaling cascade that regulates cell proliferation and survival. IGF2 has several key functions, including: 1. **Regulation of cell growth and differentiation**: IGF2 regulates cell growth and differentiation by binding to its receptor, which activates a signaling cascade that regulates cell proliferation and survival. 2. **Regulation of tissue homeostasis**: IGF2 regulates tissue homeostasis by maintaining the balance between cell growth and differentiation. 3. **Regulation of glucose metabolism**: IGF2 regulates glucose metabolism by binding to its receptor, which activates a signaling cascade that regulates insulin sensitivity. **Clinical Significance** IGF2 has been implicated in various diseases, including: 1. **Growth disorders**: IGF2 deficiency or overexpression has been associated with growth disorders, such as growth hormone deficiency and gigantism. 2. **Cancer**: IGF2 has been implicated in the development and progression of certain cancers, such as hepatocellular carcinoma and colon cancer. 3. **Neurological disorders**: IGF2 has been implicated in the development and progression of certain neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Diabetes**: IGF2 has been implicated in the development and progression of insulin resistance and type 2 diabetes. In conclusion, IGF2 is a critical regulator of growth and development, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the complex role of IGF2 in human disease and to develop effective therapeutic strategies to target this gene.

Genular Protein ID: 2134801756

Symbol: IGF2_HUMAN

Name: Insulin-like growth factor II

UniProtKB Accession Codes:

P01344 B3KX48 B7WP08 C9JAF2 E3UN45 P78449 Q14299 Q1WM26 Q9UC68 Q9UC69

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 24 EMDB 7 Ensembl 9 EvolutionaryTrace 1 GO 40 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 5 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 15 PIR 3 PRINTS 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 5 RefSeq 5 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6382022

Title: Insulin-like growth factor II precursor gene organization in relation to insulin gene family.

PubMed ID: 6382022

DOI: 10.1038/310777a0

PubMed ID: 6382021

Title: Sequence of a cDNA clone encoding human preproinsulin-like growth factor II.

PubMed ID: 6382021

DOI: 10.1038/310775a0

PubMed ID: 2450353

Title: Isolation of an insulin-like growth factor II cDNA with a unique 5' untranslated region from human placenta.

PubMed ID: 2450353

DOI: 10.1073/pnas.85.6.1947

PubMed ID: 3002851

Title: Organization of the human genes for insulin-like growth factors I and II.

PubMed ID: 3002851

DOI: 10.1016/0014-5793(86)80156-9

PubMed ID: 3476948

Title: Tissue-specific expression of insulin-like growth factor II mRNAs with distinct 5' untranslated regions.

PubMed ID: 3476948

DOI: 10.1073/pnas.84.18.6330

PubMed ID: 3683205

Title: Human insulin-like growth factor I and II messenger RNA: isolation of complementary DNA and analysis of expression.

PubMed ID: 3683205

DOI: 10.1016/s0076-6879(87)46026-6

PubMed ID: 3881277

Title: Nucleotide sequences of cDNAs encoding precursors of human insulin-like growth factor II (IGF-II) and an IGF-II variant.

PubMed ID: 3881277

DOI: 10.1016/0014-5793(85)80527-5

PubMed ID: 7730145

Title: Isolation of a cDNA for a growth factor of vascular endothelial cells from human lung cancer cells: its identity with insulin-like growth factor II.

PubMed ID: 7730145

DOI: 10.1111/j.1349-7006.1995.tb03040.x

PubMed ID: 16531418

Title: Imprinting of IGF2 P0 transcript and novel alternatively spliced INS-IGF2 isoforms show differences between mouse and human.

PubMed ID: 16531418

DOI: 10.1093/hmg/ddl041

PubMed ID: 20842449

Title: Down-regulation of achaete-scute complex homolog 1 (ASCL1) in neuroblastoma cells induces up-regulation of insulin-like growth factor 2 (IGF2).

PubMed ID: 20842449

DOI: 10.1007/s11033-010-0259-z

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3167054

Title: Differential expression of the human insulin-like growth factor II gene. Characterization of the IGF-II mRNAs and an mRNA encoding a putative IGF-II-associated protein.

PubMed ID: 3167054

DOI: 10.1016/0167-4781(88)90124-8

PubMed ID: 3653397

Title: A new 5'-non-coding region for human placental insulin-like growth factor II mRNA expression.

PubMed ID: 3653397

DOI: 10.1016/0014-5793(87)80216-8

PubMed ID: 3652904

Title: Tissue-specific and developmentally regulated transcription of the insulin-like growth factor 2 gene.

PubMed ID: 3652904

DOI: 10.1089/dna.1987.6.283

PubMed ID: 658418

Title: Primary structure of human insulin-like growth factor II.

PubMed ID: 658418

DOI: 10.1016/0014-5793(78)80237-3

PubMed ID: 2722836

Title: Structure and activity dependence of recombinant human insulin-like growth factor II on disulfide bond pairing.

PubMed ID: 2722836

DOI: 10.1016/s0021-9258(18)60533-2

PubMed ID: 7633596

Title: Purification and characterization of insulin-like growth factor II (IGF II) and an IGF II variant from human placenta.

PubMed ID: 7633596

DOI: 10.1016/0378-4347(94)00576-q

PubMed ID: 1569071

Title: The identification of O-glycosylated precursors of insulin-like growth factor II.

PubMed ID: 1569071

DOI: 10.1016/s0021-9258(18)42420-9

PubMed ID: 11448941

Title: Positive associations between single nucleotide polymorphisms in the IGF2 gene region and body mass index in adult males.

PubMed ID: 11448941

DOI: 10.1093/hmg/10.14.1491

PubMed ID: 12586351

Title: Detection of bound and free IGF-1 and IGF-2 in human plasma via biomolecular interaction analysis mass spectrometry.

PubMed ID: 12586351

DOI: 10.1016/s0014-5793(03)00042-5

PubMed ID: 15359740

Title: Quantitative mass spectrometric immunoassay of insulin like growth factor 1.

PubMed ID: 15359740

DOI: 10.1021/pr0499388

PubMed ID: 16040806

Title: Role of pro-IGF-II processing by proprotein convertase 4 in human placental development.

PubMed ID: 16040806

DOI: 10.1073/pnas.0502357102

PubMed ID: 16912056

Title: Preptin, another peptide product of the pancreatic beta-cell, is osteogenic in vitro and in vivo.

PubMed ID: 16912056

DOI: 10.1152/ajpendo.00642.2005

PubMed ID: 19066168

Title: Epigenetic mutations of the imprinted IGF2-H19 domain in Silver-Russell syndrome (SRS): results from a large cohort of patients with SRS and SRS-like phenotypes.

PubMed ID: 19066168

DOI: 10.1136/jmg.2008.061820

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

PubMed ID: 24593700

Title: Insulin-like growth factor-II: its role in metabolic and endocrine disease.

PubMed ID: 24593700

DOI: 10.1111/cen.12446

PubMed ID: 26154720

Title: Paternally inherited IGF2 mutation and growth restriction.

PubMed ID: 26154720

DOI: 10.1056/nejmoa1415227

PubMed ID: 28873464

Title: Direct integrin binding to insulin-like growth factor-2 through the C-domain is required for insulin-like growth factor receptor type 1 (IGF1R) signaling.

PubMed ID: 28873464

DOI: 10.1371/journal.pone.0184285

PubMed ID: 6189745

Title: Tertiary structures, receptor binding, and antigenicity of insulinlike growth factors.

PubMed ID: 6189745

PubMed ID: 7527339

Title: Solution structure of human insulin-like growth factor II; recognition sites for receptors and binding proteins.

PubMed ID: 7527339

DOI: 10.1002/j.1460-2075.1994.tb06896.x

PubMed ID: 18046459

Title: Structure and functional analysis of the IGF-II/IGF2R interaction.

PubMed ID: 18046459

DOI: 10.1038/sj.emboj.7601938

PubMed ID: 28796236

Title: Genetic disruption of the oncogenic HMGA2-PLAG1-IGF2 pathway causes fetal growth restriction.

PubMed ID: 28796236

DOI: 10.1038/gim.2017.105

Sequence Information:

  • Length: 180
  • Mass: 20140
  • Checksum: C1B0EB1E016BA37A
  • Sequence:
    • MGIPMGKSML VLLTFLAFAS CCIAAYRPSE TLCGGELVDT LQFVCGDRGF YFSRPASRVS 
RRSRGIVEEC CFRSCDLALL ETYCATPAKS ERDVSTPPTV LPDNFPRYPV GKFFQYDTWK 
QSTQRLRRGL PALLRARRGH VLAKELEAFR EAKRHRPLIA LPTQDPAHGG APPEMASNRK

Genular Protein ID: 506551979

Symbol: E3UN46_HUMAN

Name: N/A

UniProtKB Accession Codes:

E3UN46

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 14 Gene3D 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 3 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SAM 2 SMART 2 SMR 1 SUPFAM 1

Citations:

PubMed ID: 20842449

Title: Down-regulation of achaete-scute complex homolog 1 (ASCL1) in neuroblastoma cells induces up-regulation of insulin-like growth factor 2 (IGF2).

PubMed ID: 20842449

DOI: 10.1007/s11033-010-0259-z

Sequence Information:

  • Length: 109
  • Mass: 12029
  • Checksum: 55AF81E6017D70F9
  • Sequence:
    • MGIPMGKSML VLLTFLAFAS CCIAAYRPSE TLCGGELVDT LQFVCGDRGF YFSRPASRVS 
RRSRGIVEEC CFRSCDLALL ETYCATPAKS ERDVSTPPTV LPDNFPRYP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.