Details for: IGF2

Gene ID: 3481

Symbol: IGF2

Ensembl ID: ENSG00000167244

Description: insulin like growth factor 2

Associated with

  • Hemostasis
    (R-HSA-109582)
  • Igf1r signaling cascade
    (R-HSA-2428924)
  • Irs-related events triggered by igf1r
    (R-HSA-2428928)
  • Metabolism of proteins
    (R-HSA-392499)
  • Platelet activation, signaling and aggregation
    (R-HSA-76002)
  • Platelet degranulation
    (R-HSA-114608)
  • Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
    (R-HSA-381426)
  • Response to elevated platelet cytosolic ca2+
    (R-HSA-76005)
  • Shc-related events triggered by igf1r
    (R-HSA-2428933)
  • Signaling by receptor tyrosine kinases
    (R-HSA-9006934)
  • Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
    (R-HSA-2404192)
  • Signal transduction
    (R-HSA-162582)
  • Animal organ morphogenesis
    (GO:0009887)
  • Embryonic placenta development
    (GO:0001892)
  • Embryonic placenta morphogenesis
    (GO:0060669)
  • Exocrine pancreas development
    (GO:0031017)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Genomic imprinting
    (GO:0071514)
  • Glucose metabolic process
    (GO:0006006)
  • Growth factor activity
    (GO:0008083)
  • Hormone activity
    (GO:0005179)
  • Insulin-like growth factor receptor binding
    (GO:0005159)
  • Insulin-like growth factor receptor signaling pathway
    (GO:0048009)
  • Insulin receptor binding
    (GO:0005158)
  • Insulin receptor signaling pathway
    (GO:0008286)
  • Integrin binding
    (GO:0005178)
  • In utero embryonic development
    (GO:0001701)
  • Negative regulation of muscle cell differentiation
    (GO:0051148)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Osteoblast differentiation
    (GO:0001649)
  • Platelet alpha granule lumen
    (GO:0031093)
  • Positive regulation of activated t cell proliferation
    (GO:0042104)
  • Positive regulation of cell division
    (GO:0051781)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of glycogen biosynthetic process
    (GO:0045725)
  • Positive regulation of insulin receptor signaling pathway
    (GO:0046628)
  • Positive regulation of mapk cascade
    (GO:0043410)
  • Positive regulation of mitotic nuclear division
    (GO:0045840)
  • Positive regulation of multicellular organism growth
    (GO:0040018)
  • Positive regulation of organ growth
    (GO:0046622)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of skeletal muscle tissue growth
    (GO:0048633)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of vascular endothelial cell proliferation
    (GO:1905564)
  • Protein binding
    (GO:0005515)
  • Protein serine/threonine kinase activator activity
    (GO:0043539)
  • Receptor ligand activity
    (GO:0048018)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of muscle cell differentiation
    (GO:0051147)
  • Striated muscle cell differentiation
    (GO:0051146)
  • Transmembrane receptor protein tyrosine kinase activator activity
    (GO:0030297)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 20.17
    Marker Score: 24348
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 16.48
    Marker Score: 54002
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 14.77
    Marker Score: 262154
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 9.49
    Marker Score: 7221.5
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 9.03
    Marker Score: 6422
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 6.91
    Marker Score: 5677
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 6.54
    Marker Score: 2162
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 6.33
    Marker Score: 4232
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 5.15
    Marker Score: 7249.5
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 4.91
    Marker Score: 2541
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.48
    Marker Score: 22616
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 3.07
    Marker Score: 1915
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 2.81
    Marker Score: 1059
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.79
    Marker Score: 2412
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.76
    Marker Score: 24238
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.7
    Marker Score: 4165
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.65
    Marker Score: 4505
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.58
    Marker Score: 2746
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.56
    Marker Score: 11028
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.43
    Marker Score: 27402
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.35
    Marker Score: 2529
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.34
    Marker Score: 9214
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.29
    Marker Score: 23047.5
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.04
    Marker Score: 578
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 2.01
    Marker Score: 697
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.9
    Marker Score: 5163
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.81
    Marker Score: 785
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.73
    Marker Score: 1223
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.65
    Marker Score: 800
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.65
    Marker Score: 931
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.59
    Marker Score: 877
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.56
    Marker Score: 1392
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.55
    Marker Score: 1562
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.51
    Marker Score: 19932
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.45
    Marker Score: 1368
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.44
    Marker Score: 956
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.43
    Marker Score: 3356
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.36
    Marker Score: 907
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.35
    Marker Score: 653
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.35
    Marker Score: 2074
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.34
    Marker Score: 263
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.25
    Marker Score: 5198
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.25
    Marker Score: 500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.2
    Marker Score: 619
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.18
    Marker Score: 1250
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.15
    Marker Score: 2011.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.11
    Marker Score: 702.5
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.09
    Marker Score: 277
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.04
    Marker Score: 36012
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.03
    Marker Score: 270
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71798
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48023
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.99
    Marker Score: 1032
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.97
    Marker Score: 350
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5340
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.94
    Marker Score: 1519
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.93
    Marker Score: 240
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.92
    Marker Score: 298
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.91
    Marker Score: 838.5
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.91
    Marker Score: 785
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.89
    Marker Score: 1231
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.86
    Marker Score: 13399
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.86
    Marker Score: 653.5
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.81
    Marker Score: 207
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.81
    Marker Score: 2120
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.79
    Marker Score: 194
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 698
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.75
    Marker Score: 176
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.73
    Marker Score: 24987
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.72
    Marker Score: 325.5
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.7
    Marker Score: 4181
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.69
    Marker Score: 223
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.69
    Marker Score: 687
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.68
    Marker Score: 237
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.68
    Marker Score: 974
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.68
    Marker Score: 198
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.67
    Marker Score: 602.5
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.66
    Marker Score: 362
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.64
    Marker Score: 510
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.64
    Marker Score: 179
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.63
    Marker Score: 147
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.62
    Marker Score: 154
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.62
    Marker Score: 1256
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.61
    Marker Score: 137
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.6
    Marker Score: 639
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.6
    Marker Score: 3974
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.6
    Marker Score: 333
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.59
    Marker Score: 693
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.57
    Marker Score: 549
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.57
    Marker Score: 1186
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.57
    Marker Score: 372
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.56
    Marker Score: 131
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.54
    Marker Score: 157

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Other Information

**Key characteristics:** * IGF2 is a glycoprotein with a molecular weight of approximately 125 kDa. * It is a secreted protein that can be found in plasma and other bodily fluids. * IGF2 is a potent activator of the IGF1 receptor. * It has been shown to play a role in a variety of biological processes, including cell growth, differentiation, and metabolism. **Pathways and functions:** * IGF2 binds to the IGF1 receptor, which is expressed on a variety of cell types. * Binding of IGF2 to the IGF1 receptor triggers a signaling cascade that involves the activation of the PI3K/Akt pathway. * The PI3K/Akt pathway is a major signaling pathway in cells. It is involved in a wide range of cellular processes, including cell growth, differentiation, and metabolism. * IGF2 also has a number of other effects on cells, including promoting cell proliferation, differentiation, and survival. **Clinical significance:** * Mutations in the IGF2 gene have been linked to a number of human diseases, including cancer, cardiovascular disease, and diabetes. * IGF2 is a potential therapeutic target for a variety of diseases. * Studies of IGF2 and its signaling pathway have led to the development of new diagnostic and therapeutic tools for cancer and other diseases. **Additional information:** * IGF2 is a highly conserved protein. It is found in humans, mice, and rats. * It is produced by a variety of cell types, including mesangial cells, hepatoblasts, and skeletal muscle cells. * It is a secreted protein that can be found in plasma and other bodily fluids. * It is a potent activator of the IGF1 receptor. * It has been shown to play a role in a variety of biological processes, including cell growth, differentiation, and metabolism.

Genular Protein ID: 2134801756

Symbol: IGF2_HUMAN

Name: Insulin-like growth factor II

UniProtKB Accession Codes:

P01344 B3KX48 B7WP08 C9JAF2 E3UN45 P78449 Q14299 Q1WM26 Q9UC68 Q9UC69

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 24 EMDB 3 Ensembl 9 EvolutionaryTrace 1 GO 41 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 5 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 11 PIR 3 PRINTS 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 5 RefSeq 5 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6382022

Title: Insulin-like growth factor II precursor gene organization in relation to insulin gene family.

PubMed ID: 6382022

DOI: 10.1038/310777a0

PubMed ID: 6382021

Title: Sequence of a cDNA clone encoding human preproinsulin-like growth factor II.

PubMed ID: 6382021

DOI: 10.1038/310775a0

PubMed ID: 2450353

Title: Isolation of an insulin-like growth factor II cDNA with a unique 5' untranslated region from human placenta.

PubMed ID: 2450353

DOI: 10.1073/pnas.85.6.1947

PubMed ID: 3002851

Title: Organization of the human genes for insulin-like growth factors I and II.

PubMed ID: 3002851

DOI: 10.1016/0014-5793(86)80156-9

PubMed ID: 3476948

Title: Tissue-specific expression of insulin-like growth factor II mRNAs with distinct 5' untranslated regions.

PubMed ID: 3476948

DOI: 10.1073/pnas.84.18.6330

PubMed ID: 3683205

Title: Human insulin-like growth factor I and II messenger RNA: isolation of complementary DNA and analysis of expression.

PubMed ID: 3683205

DOI: 10.1016/s0076-6879(87)46026-6

PubMed ID: 3881277

Title: Nucleotide sequences of cDNAs encoding precursors of human insulin-like growth factor II (IGF-II) and an IGF-II variant.

PubMed ID: 3881277

DOI: 10.1016/0014-5793(85)80527-5

PubMed ID: 7730145

Title: Isolation of a cDNA for a growth factor of vascular endothelial cells from human lung cancer cells: its identity with insulin-like growth factor II.

PubMed ID: 7730145

DOI: 10.1111/j.1349-7006.1995.tb03040.x

PubMed ID: 16531418

Title: Imprinting of IGF2 P0 transcript and novel alternatively spliced INS-IGF2 isoforms show differences between mouse and human.

PubMed ID: 16531418

DOI: 10.1093/hmg/ddl041

PubMed ID: 20842449

Title: Down-regulation of achaete-scute complex homolog 1 (ASCL1) in neuroblastoma cells induces up-regulation of insulin-like growth factor 2 (IGF2).

PubMed ID: 20842449

DOI: 10.1007/s11033-010-0259-z

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3167054

Title: Differential expression of the human insulin-like growth factor II gene. Characterization of the IGF-II mRNAs and an mRNA encoding a putative IGF-II-associated protein.

PubMed ID: 3167054

DOI: 10.1016/0167-4781(88)90124-8

PubMed ID: 3653397

Title: A new 5'-non-coding region for human placental insulin-like growth factor II mRNA expression.

PubMed ID: 3653397

DOI: 10.1016/0014-5793(87)80216-8

PubMed ID: 3652904

Title: Tissue-specific and developmentally regulated transcription of the insulin-like growth factor 2 gene.

PubMed ID: 3652904

DOI: 10.1089/dna.1987.6.283

PubMed ID: 658418

Title: Primary structure of human insulin-like growth factor II.

PubMed ID: 658418

DOI: 10.1016/0014-5793(78)80237-3

PubMed ID: 2722836

Title: Structure and activity dependence of recombinant human insulin-like growth factor II on disulfide bond pairing.

PubMed ID: 2722836

DOI: 10.1016/s0021-9258(18)60533-2

PubMed ID: 7633596

Title: Purification and characterization of insulin-like growth factor II (IGF II) and an IGF II variant from human placenta.

PubMed ID: 7633596

DOI: 10.1016/0378-4347(94)00576-q

PubMed ID: 1569071

Title: The identification of O-glycosylated precursors of insulin-like growth factor II.

PubMed ID: 1569071

DOI: 10.1016/s0021-9258(18)42420-9

PubMed ID: 11448941

Title: Positive associations between single nucleotide polymorphisms in the IGF2 gene region and body mass index in adult males.

PubMed ID: 11448941

DOI: 10.1093/hmg/10.14.1491

PubMed ID: 12586351

Title: Detection of bound and free IGF-1 and IGF-2 in human plasma via biomolecular interaction analysis mass spectrometry.

PubMed ID: 12586351

DOI: 10.1016/s0014-5793(03)00042-5

PubMed ID: 15359740

Title: Quantitative mass spectrometric immunoassay of insulin like growth factor 1.

PubMed ID: 15359740

DOI: 10.1021/pr0499388

PubMed ID: 16040806

Title: Role of pro-IGF-II processing by proprotein convertase 4 in human placental development.

PubMed ID: 16040806

DOI: 10.1073/pnas.0502357102

PubMed ID: 16912056

Title: Preptin, another peptide product of the pancreatic beta-cell, is osteogenic in vitro and in vivo.

PubMed ID: 16912056

DOI: 10.1152/ajpendo.00642.2005

PubMed ID: 19066168

Title: Epigenetic mutations of the imprinted IGF2-H19 domain in Silver-Russell syndrome (SRS): results from a large cohort of patients with SRS and SRS-like phenotypes.

PubMed ID: 19066168

DOI: 10.1136/jmg.2008.061820

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

PubMed ID: 24593700

Title: Insulin-like growth factor-II: its role in metabolic and endocrine disease.

PubMed ID: 24593700

DOI: 10.1111/cen.12446

PubMed ID: 26154720

Title: Paternally inherited IGF2 mutation and growth restriction.

PubMed ID: 26154720

DOI: 10.1056/nejmoa1415227

PubMed ID: 28873464

Title: Direct integrin binding to insulin-like growth factor-2 through the C-domain is required for insulin-like growth factor receptor type 1 (IGF1R) signaling.

PubMed ID: 28873464

DOI: 10.1371/journal.pone.0184285

PubMed ID: 6189745

Title: Tertiary structures, receptor binding, and antigenicity of insulinlike growth factors.

PubMed ID: 6189745

PubMed ID: 7527339

Title: Solution structure of human insulin-like growth factor II; recognition sites for receptors and binding proteins.

PubMed ID: 7527339

DOI: 10.1002/j.1460-2075.1994.tb06896.x

PubMed ID: 18046459

Title: Structure and functional analysis of the IGF-II/IGF2R interaction.

PubMed ID: 18046459

DOI: 10.1038/sj.emboj.7601938

PubMed ID: 28796236

Title: Genetic disruption of the oncogenic HMGA2-PLAG1-IGF2 pathway causes fetal growth restriction.

PubMed ID: 28796236

DOI: 10.1038/gim.2017.105

Sequence Information:

  • Length: 180
  • Mass: 20140
  • Checksum: C1B0EB1E016BA37A
  • Sequence:
    • MGIPMGKSML VLLTFLAFAS CCIAAYRPSE TLCGGELVDT LQFVCGDRGF YFSRPASRVS 
RRSRGIVEEC CFRSCDLALL ETYCATPAKS ERDVSTPPTV LPDNFPRYPV GKFFQYDTWK 
QSTQRLRRGL PALLRARRGH VLAKELEAFR EAKRHRPLIA LPTQDPAHGG APPEMASNRK

Genular Protein ID: 506551979

Symbol: E3UN46_HUMAN

Name: N/A

UniProtKB Accession Codes:

E3UN46

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 4 Gene3D 1 GenomeRNAi 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 3 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SAM 2 SMART 2 SMR 1 SUPFAM 1

Citations:

PubMed ID: 20842449

Title: Down-regulation of achaete-scute complex homolog 1 (ASCL1) in neuroblastoma cells induces up-regulation of insulin-like growth factor 2 (IGF2).

PubMed ID: 20842449

DOI: 10.1007/s11033-010-0259-z

Sequence Information:

  • Length: 109
  • Mass: 12029
  • Checksum: 55AF81E6017D70F9
  • Sequence:
    • MGIPMGKSML VLLTFLAFAS CCIAAYRPSE TLCGGELVDT LQFVCGDRGF YFSRPASRVS 
RRSRGIVEEC CFRSCDLALL ETYCATPAKS ERDVSTPPTV LPDNFPRYP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.