Details for: FILIP1

Gene ID: 27145

Symbol: FILIP1

Ensembl ID: ENSG00000118407

Description: filamin A interacting protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 117.7835
    Cell Significance Index: -29.8800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 61.0451
    Cell Significance Index: -24.8000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 59.0736
    Cell Significance Index: -27.8900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.9546
    Cell Significance Index: -24.7800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 10.1644
    Cell Significance Index: 248.0100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.3074
    Cell Significance Index: -20.3700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.5569
    Cell Significance Index: -29.8200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 6.9491
    Cell Significance Index: 533.2600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 6.6249
    Cell Significance Index: 170.2900
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 6.1877
    Cell Significance Index: 99.8400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 5.5827
    Cell Significance Index: 82.4200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.9110
    Cell Significance Index: 56.8200
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.8234
    Cell Significance Index: 9.6000
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 1.4814
    Cell Significance Index: 6.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.1215
    Cell Significance Index: 509.0200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.0480
    Cell Significance Index: 15.0500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9499
    Cell Significance Index: 20.5800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.8712
    Cell Significance Index: 12.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7513
    Cell Significance Index: 142.9700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.6700
    Cell Significance Index: 45.0500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.6192
    Cell Significance Index: 64.4700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4279
    Cell Significance Index: 386.3700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3051
    Cell Significance Index: 574.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2965
    Cell Significance Index: 29.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2732
    Cell Significance Index: 54.8000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2513
    Cell Significance Index: 13.0900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1924
    Cell Significance Index: 31.2900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1667
    Cell Significance Index: 8.4200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1333
    Cell Significance Index: 7.4800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0925
    Cell Significance Index: 64.0100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0789
    Cell Significance Index: 1.2200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0530
    Cell Significance Index: 0.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0472
    Cell Significance Index: 25.7800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0387
    Cell Significance Index: 4.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0217
    Cell Significance Index: 7.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0204
    Cell Significance Index: 15.4600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0185
    Cell Significance Index: 11.7500
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.0113
    Cell Significance Index: 0.0700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0026
    Cell Significance Index: 0.0900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0021
    Cell Significance Index: 0.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0014
    Cell Significance Index: 2.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0011
    Cell Significance Index: -0.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0013
    Cell Significance Index: -1.9700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0144
    Cell Significance Index: -19.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0233
    Cell Significance Index: -2.9900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0269
    Cell Significance Index: -0.7800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0326
    Cell Significance Index: -14.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0340
    Cell Significance Index: -24.9300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0396
    Cell Significance Index: -0.9900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0414
    Cell Significance Index: -30.6900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0495
    Cell Significance Index: -30.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0507
    Cell Significance Index: -7.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0534
    Cell Significance Index: -30.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0718
    Cell Significance Index: -12.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0756
    Cell Significance Index: -13.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0896
    Cell Significance Index: -3.9700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0901
    Cell Significance Index: -25.9300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0909
    Cell Significance Index: -4.1200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1053
    Cell Significance Index: -7.2900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1393
    Cell Significance Index: -1.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1499
    Cell Significance Index: -31.5800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1514
    Cell Significance Index: -18.6200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1528
    Cell Significance Index: -5.7900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1705
    Cell Significance Index: -23.4100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1866
    Cell Significance Index: -4.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1949
    Cell Significance Index: -19.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1987
    Cell Significance Index: -23.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2271
    Cell Significance Index: -13.9600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2329
    Cell Significance Index: -30.0900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2411
    Cell Significance Index: -14.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2617
    Cell Significance Index: -29.9800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2638
    Cell Significance Index: -31.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2804
    Cell Significance Index: -17.1900
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.2864
    Cell Significance Index: -1.3700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.3221
    Cell Significance Index: -4.1300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3230
    Cell Significance Index: -9.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3393
    Cell Significance Index: -26.8800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.3587
    Cell Significance Index: -5.7600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3777
    Cell Significance Index: -10.1200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3806
    Cell Significance Index: -12.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4029
    Cell Significance Index: -30.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4432
    Cell Significance Index: -28.5900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4578
    Cell Significance Index: -14.5800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4637
    Cell Significance Index: -21.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4638
    Cell Significance Index: -29.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4667
    Cell Significance Index: -24.5100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4923
    Cell Significance Index: -8.7000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5013
    Cell Significance Index: -10.4000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5236
    Cell Significance Index: -10.9600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5283
    Cell Significance Index: -24.8300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5299
    Cell Significance Index: -17.3500
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.5333
    Cell Significance Index: -5.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5387
    Cell Significance Index: -27.9900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5437
    Cell Significance Index: -11.5400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5730
    Cell Significance Index: -6.5100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.6082
    Cell Significance Index: -8.7100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.6279
    Cell Significance Index: -9.4600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6616
    Cell Significance Index: -14.0900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6677
    Cell Significance Index: -23.3900
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.6678
    Cell Significance Index: -8.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular localization:** FILIP1 is widely expressed in various cell types, including cardiac myocytes, smooth muscle cells, epithelial cells, and pericytes. 2. **Protein interactions:** FILIP1 interacts with filamin A, a protein that regulates actin cytoskeleton dynamics. 3. **Rho GTPase regulation:** FILIP1 modulates the activity of Rho GTPases, a family of small GTP-binding proteins that regulate various cellular processes. 4. **Cytoskeletal dynamics:** FILIP1 plays a role in regulating actin cytoskeleton organization and dynamics, which is essential for cellular motility, structure, and function. **Pathways and Functions:** 1. **Actin cytoskeleton dynamics:** FILIP1 regulates actin cytoskeleton organization and dynamics, which is essential for cellular motility, structure, and function. 2. **Rho GTPase cycle:** FILIP1 modulates the activity of Rho GTPases, a family of small GTP-binding proteins that regulate various cellular processes, including cell migration, proliferation, and apoptosis. 3. **Signaling by Rho GTPases:** FILIP1 regulates the activity of Rho GTPases, which are involved in various signaling pathways, including the regulation of cytoskeletal dynamics, cell migration, and apoptosis. 4. **Cytosol and plasma membrane signaling:** FILIP1 regulates the activity of Rho GTPases, which are involved in signaling pathways that regulate cytoskeletal dynamics, cell migration, and apoptosis. **Clinical Significance:** 1. **Cardiovascular disorders:** Dysregulation of FILIP1 has been implicated in various cardiovascular disorders, including heart failure and arrhythmias. 2. **Cancer:** FILIP1 has been implicated in the regulation of cell proliferation and apoptosis in various types of cancer, including breast and lung cancer. 3. **Musculoskeletal disorders:** FILIP1 has been implicated in the regulation of muscle contraction and relaxation, which is essential for maintaining muscle function and preventing musculoskeletal disorders. 4. **Neurological disorders:** FILIP1 has been implicated in the regulation of neuronal motility and function, which is essential for maintaining neuronal health and preventing neurological disorders. In conclusion, FILIP1 is a multifunctional gene that plays a crucial role in regulating cytoskeletal dynamics and cellular signaling pathways. The dysregulation of FILIP1 has been implicated in various diseases, including cardiovascular disorders, cancer, and musculoskeletal disorders. Further research is needed to fully understand the role of FILIP1 in human health and disease.

Genular Protein ID: 2593550362

Symbol: FLIP1_HUMAN

Name: Filamin-A-interacting protein 1

UniProtKB Accession Codes:

Q7Z7B0 B2RMU6 Q5VUL6 Q86TC3 Q8N8B9 Q96SK6 Q9NVI8 Q9ULE5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 2 ExpressionAtlas 1 GO 6 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 5 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10574462

Title: Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10574462

DOI: 10.1093/dnares/6.5.337

PubMed ID: 23087206

Title: RhoD regulates cytoskeletal dynamics via the actin nucleation-promoting factor WASp homologue associated with actin Golgi membranes and microtubules.

PubMed ID: 23087206

DOI: 10.1091/mbc.e12-07-0555

PubMed ID: 36943452

Title: Homozygous loss-of-function variants in FILIP1 cause autosomal recessive arthrogryposis multiplex congenita with microcephaly.

PubMed ID: 36943452

DOI: 10.1007/s00439-023-02528-2

PubMed ID: 37163662

Title: Bi-allelic variants of FILIP1 cause congenital myopathy, dysmorphism and neurological defects.

PubMed ID: 37163662

DOI: 10.1093/brain/awad152

Sequence Information:

  • Length: 1213
  • Mass: 138109
  • Checksum: EE4329B03516E6AF
  • Sequence:
    • MRSRNQGGES ASDGHISCPK PSIIGNAGEK SLSEDAKKKK KSNRKEDDVM ASGTVKRHLK 
TSGECERKTK KSLELSKEDL IQLLSIMEGE LQAREDVIHM LKTEKTKPEV LEAHYGSAEP 
EKVLRVLHRD AILAQEKSIG EDVYEKPISE LDRLEEKQKE TYRRMLEQLL LAEKCHRRTV 
YELENEKHKH TDYMNKSDDF TNLLEQERER LKKLLEQEKA YQARKEKENA KRLNKLRDEL 
VKLKSFALML VDERQMHIEQ LGLQSQKVQD LTQKLREEEE KLKAITSKSK EDRQKLLKLE 
VDFEHKASRF SQEHEEMNAK LANQESHNRQ LRLKLVGLTQ RIEELEETNK NLQKAEEELQ 
ELRDKIAKGE CGNSSLMAEV ENLRKRVLEM EGKDEEITKT ESQCRELRKK LQEEEHHSKE 
LRLEVEKLQK RMSELEKLEE AFSKSKSECT QLHLNLEKEK NLTKDLLNEL EVVKSRVKEL 
ECSESRLEKA ELSLKDDLTK LKSFTVMLVD ERKNMMEKIK QEERKVDGLN KNFKVEQGKV 
MDVTEKLIEE SKKLLKLKSE MEEKVYNLTR ERDELIGKLK SEEEKSSELS CSVDLLKKRL 
DGIEEVEREI TRGRSRKGSE LTCPEDNKIK ELTLEIERLK KRLQQLEVVE GDLMKTEDEY 
DQLEQKFRTE QDKANFLSQQ LEEIKHQIAK NKAIEKGEVV SQEAELRHRF RLEEAKSRDL 
KAEVQALKEK IHELMNKEDQ LSQLQVDYSV LQQRFMEEEN KNKNMGQEVL NLTKELELSK 
RYSRALRPSV NGRRMVDVPV TSTGVQTDAV SGEAAEEETP AVFIRKSFQE ENHIMSNLRQ 
VGLKKPVERS SVLDRYPPAA NELTMRKSWI PWMRKRENGP SITQEKGPRT NSSPGHPGEV 
VLSPKQGQPL HIRVTPDHEN STATLEITSP TSEEFFSSTT VIPTLGNQKP RITIIPSPNV 
MPQKQKSGDT TLGPERAMSP VTITTFSREK TPESGRGAFA DRPTSPIQIM TVSTSAAPAE 
IAVSPESQEM PMGRTILKVT PEKQTVPTPV RKYNSNANII TTEDNKIHIH LGSQFKRSPG 
TSGEGVSPVI TVRPVNVTAE KEVSTGTVLR SPRNHLSSRP GASKVTSTIT ITPVTTSSAR 
GTQSVSGQDG SSQRPTPTRI PMSKGMKAGK PVVAAPGAGN LTKFEPRAET QSMKIELKKS 
AASSTTSLGG GKG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.