Details for: MYL11

Gene ID: 29895

Symbol: MYL11

Ensembl ID: ENSG00000180209

Description: myosin light chain 11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 37.8668
    Cell Significance Index: -5.8900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 19.4367
    Cell Significance Index: -4.9300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 13.7718
    Cell Significance Index: 222.2100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 11.8644
    Cell Significance Index: -4.8200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.8177
    Cell Significance Index: -5.9400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 2.3583
    Cell Significance Index: 57.5400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.1688
    Cell Significance Index: -5.8100
  • Cell Name: secondary lymphoid organ macrophage (CL0000867)
    Fold Change: 1.8240
    Cell Significance Index: 13.3900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.5281
    Cell Significance Index: -6.0300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.4754
    Cell Significance Index: 16.0400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7442
    Cell Significance Index: 73.6200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6005
    Cell Significance Index: 542.2300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.5600
    Cell Significance Index: 7.8600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4440
    Cell Significance Index: 48.3000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4003
    Cell Significance Index: 65.1100
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.3847
    Cell Significance Index: 3.2700
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.2711
    Cell Significance Index: 3.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2549
    Cell Significance Index: 13.2400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2343
    Cell Significance Index: 4.9100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2175
    Cell Significance Index: 15.0400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.2069
    Cell Significance Index: 3.3200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1848
    Cell Significance Index: 4.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1740
    Cell Significance Index: 31.3600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1518
    Cell Significance Index: 28.8800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1377
    Cell Significance Index: 75.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1205
    Cell Significance Index: 34.6600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1055
    Cell Significance Index: 4.7800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0974
    Cell Significance Index: 2.6500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0908
    Cell Significance Index: 2.4300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0873
    Cell Significance Index: 2.2300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0817
    Cell Significance Index: 10.0500
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.0699
    Cell Significance Index: 0.7300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0660
    Cell Significance Index: 23.6700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0651
    Cell Significance Index: 13.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0399
    Cell Significance Index: 1.8600
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.0301
    Cell Significance Index: 0.3100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0288
    Cell Significance Index: 0.8300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0270
    Cell Significance Index: 1.7400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0212
    Cell Significance Index: 2.7200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0204
    Cell Significance Index: 2.6300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0187
    Cell Significance Index: 0.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0166
    Cell Significance Index: 0.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0151
    Cell Significance Index: 0.7100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0068
    Cell Significance Index: 0.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0048
    Cell Significance Index: 0.6600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0033
    Cell Significance Index: 0.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0026
    Cell Significance Index: 4.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0022
    Cell Significance Index: 4.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0021
    Cell Significance Index: 0.9100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.3300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0018
    Cell Significance Index: -2.3800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0041
    Cell Significance Index: -0.1100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0042
    Cell Significance Index: -0.2100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0050
    Cell Significance Index: -3.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0055
    Cell Significance Index: -4.1300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0062
    Cell Significance Index: -4.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0070
    Cell Significance Index: -5.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0075
    Cell Significance Index: -0.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0080
    Cell Significance Index: -0.2800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0083
    Cell Significance Index: -4.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0101
    Cell Significance Index: -0.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0105
    Cell Significance Index: -4.7500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0126
    Cell Significance Index: -0.5200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0196
    Cell Significance Index: -0.2800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0216
    Cell Significance Index: -0.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0219
    Cell Significance Index: -4.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0224
    Cell Significance Index: -3.8300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0263
    Cell Significance Index: -3.8200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0284
    Cell Significance Index: -3.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0304
    Cell Significance Index: -6.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0312
    Cell Significance Index: -3.5700
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0388
    Cell Significance Index: -0.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0397
    Cell Significance Index: -4.0600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0424
    Cell Significance Index: -0.8800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0491
    Cell Significance Index: -0.6700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0496
    Cell Significance Index: -3.0400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0499
    Cell Significance Index: -2.6200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0499
    Cell Significance Index: -3.5300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0526
    Cell Significance Index: -3.5400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0547
    Cell Significance Index: -5.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0557
    Cell Significance Index: -4.2800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0571
    Cell Significance Index: -0.8600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0590
    Cell Significance Index: -0.6700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0645
    Cell Significance Index: -2.2400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0662
    Cell Significance Index: -5.2400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0687
    Cell Significance Index: -1.1500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0687
    Cell Significance Index: -1.9700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0868
    Cell Significance Index: -4.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0873
    Cell Significance Index: -4.9000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0974
    Cell Significance Index: -3.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1004
    Cell Significance Index: -4.4400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1032
    Cell Significance Index: -3.0400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1136
    Cell Significance Index: -4.1700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1210
    Cell Significance Index: -3.8600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1219
    Cell Significance Index: -4.2700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1222
    Cell Significance Index: -4.0000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1239
    Cell Significance Index: -4.6900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1252
    Cell Significance Index: -3.9600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1272
    Cell Significance Index: -2.7000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1278
    Cell Significance Index: -3.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene Location and Expression:** The MYL11 gene is located on chromosome 4q31.3 and is highly expressed in cells of the skeletal muscle, kidney, and immune system. 2. **Protein Structure:** MYL11 is a member of the myosin light chain family and consists of two heavy chains (β and α) and two light chains (LC2B and LC2A). 3. **Post-Translational Modifications:** MYL11 undergoes phosphorylation, which regulates its activity and interaction with other proteins. 4. **Cellular Localization:** MYL11 is primarily localized to the cytoskeleton, where it interacts with actin and myosin filaments. **Pathways and Functions:** 1. **Actin-Myosin Filament Sliding:** MYL11 plays a critical role in actin-myosin filament sliding, which is essential for muscle contraction, cell migration, and intracellular transport. 2. **Calcium Ion Binding:** MYL11 binds to calcium ions, regulating its activity and interaction with other proteins. 3. **Protein Binding:** MYL11 interacts with various proteins, including actin, myosin, and tropomyosin, to regulate its activity and subcellular localization. 4. **Immune Response:** MYL11 is involved in the regulation of immune responses, particularly in the context of lymphoid lineage restricted progenitor cells. 5. **Muscle Morphogenesis:** MYL11 is essential for muscle tissue morphogenesis, including skeletal muscle development and cardiac muscle myoblast formation. **Clinical Significance:** Dysregulation of MYL11 has been implicated in various diseases, including: 1. **Muscular Dystrophy:** Mutations in the MYL11 gene have been associated with muscular dystrophy, a group of genetic disorders characterized by progressive muscle weakness and degeneration. 2. **Immune System Disorders:** Alterations in MYL11 expression have been linked to immune system disorders, such as autoimmune diseases and lymphoma. 3. **Cancer:** MYL11 has been identified as a potential oncogene, with overexpression contributing to cancer progression and metastasis. In conclusion, the MYL11 gene is a critical regulator of immune function and muscle morphogenesis. Its dysregulation has significant implications for various diseases, highlighting the need for further research into the molecular mechanisms underlying MYL11 function.

Genular Protein ID: 3177261996

Symbol: MYL11_HUMAN

Name: MLC2B

UniProtKB Accession Codes:

Q96A32 A0A024QZG6 B2RA83 Q14843 Q6IB41

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14756420

Title: Human fast skeletal myosin light chain 2 cDNA: isolation, tissue specific expression of the single copy gene, comparative sequence analysis of isoforms and evolutionary relationships.

PubMed ID: 14756420

DOI: 10.1080/1042517031000154952

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 32707087

Title: Mutations in MYLPF Cause a Novel Segmental Amyoplasia that Manifests as Distal Arthrogryposis.

PubMed ID: 32707087

DOI: 10.1016/j.ajhg.2020.06.014

Sequence Information:

  • Length: 169
  • Mass: 19015
  • Checksum: 2CE585D6B1F8769D
  • Sequence:
    • MAPKRAKRRT VEGGSSSVFS MFDQTQIQEF KEAFTVIDQN RDGIIDKEDL RDTFAAMGRL 
NVKNEELDAM MKEASGPINF TVFLTMFGEK LKGADPEDVI TGAFKVLDPE GKGTIKKKFL 
EELLTTQCDR FSQEEIKNMW AAFPPDVGGN VDYKNICYVI THGDAKDQE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.