Details for: NFIB

Gene ID: 4781

Symbol: NFIB

Ensembl ID: ENSG00000147862

Description: nuclear factor I B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 1045.9016
    Cell Significance Index: -162.6900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 642.9894
    Cell Significance Index: -163.0900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 416.3515
    Cell Significance Index: -171.5200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 328.5375
    Cell Significance Index: -155.1100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 319.9575
    Cell Significance Index: -129.9900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 136.6232
    Cell Significance Index: -130.4400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 131.9958
    Cell Significance Index: -162.7500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 44.7092
    Cell Significance Index: -97.8500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 41.2108
    Cell Significance Index: -162.6200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 40.7218
    Cell Significance Index: -125.0800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 7.2019
    Cell Significance Index: 140.5600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 6.5520
    Cell Significance Index: 99.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 5.0785
    Cell Significance Index: 1821.5600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 4.8442
    Cell Significance Index: 297.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 3.8409
    Cell Significance Index: 294.7500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 3.6176
    Cell Significance Index: 1599.4200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 3.6002
    Cell Significance Index: 51.7800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.3919
    Cell Significance Index: 176.6800
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 3.1994
    Cell Significance Index: 28.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.0568
    Cell Significance Index: 356.2400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.5789
    Cell Significance Index: 121.2100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.4538
    Cell Significance Index: 173.5400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.3259
    Cell Significance Index: 55.7800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.1090
    Cell Significance Index: 58.9400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.0867
    Cell Significance Index: 97.2900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.9607
    Cell Significance Index: 1770.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8854
    Cell Significance Index: 378.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.8130
    Cell Significance Index: 121.9100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.5709
    Cell Significance Index: 26.9200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.4434
    Cell Significance Index: 998.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.0039
    Cell Significance Index: 1890.2700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.8775
    Cell Significance Index: 21.9400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.8136
    Cell Significance Index: 13.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7902
    Cell Significance Index: 102.0900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7395
    Cell Significance Index: 80.4400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6017
    Cell Significance Index: 328.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4883
    Cell Significance Index: 88.0200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4279
    Cell Significance Index: 9.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.4068
    Cell Significance Index: 626.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.4043
    Cell Significance Index: 745.5900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.3873
    Cell Significance Index: 526.6200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.3452
    Cell Significance Index: 219.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3054
    Cell Significance Index: 37.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1999
    Cell Significance Index: 11.2200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1500
    Cell Significance Index: 3.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0148
    Cell Significance Index: 0.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0363
    Cell Significance Index: -6.2000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0517
    Cell Significance Index: -5.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0524
    Cell Significance Index: -9.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0704
    Cell Significance Index: -10.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0809
    Cell Significance Index: -50.5100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0851
    Cell Significance Index: -38.6100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.1375
    Cell Significance Index: -100.7900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1439
    Cell Significance Index: -106.6200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1647
    Cell Significance Index: -4.7400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1855
    Cell Significance Index: -140.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2088
    Cell Significance Index: -28.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2819
    Cell Significance Index: -158.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.4015
    Cell Significance Index: -18.2000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.5454
    Cell Significance Index: -156.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.6589
    Cell Significance Index: -130.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.6899
    Cell Significance Index: -70.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.7759
    Cell Significance Index: -88.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.7868
    Cell Significance Index: -165.7300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.8000
    Cell Significance Index: -22.8300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.9164
    Cell Significance Index: -13.1600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.9384
    Cell Significance Index: -120.3000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.9980
    Cell Significance Index: -6.0300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.0490
    Cell Significance Index: -72.5500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.0551
    Cell Significance Index: -27.1200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -1.0827
    Cell Significance Index: -80.6900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.2315
    Cell Significance Index: -140.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.2506
    Cell Significance Index: -34.0400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.2830
    Cell Significance Index: -133.5900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.3346
    Cell Significance Index: -81.8300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -1.3359
    Cell Significance Index: -157.5400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.3922
    Cell Significance Index: -23.3000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.4488
    Cell Significance Index: -21.3900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.4914
    Cell Significance Index: -78.3100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.5396
    Cell Significance Index: -22.7300
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -1.6584
    Cell Significance Index: -23.1900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.7643
    Cell Significance Index: -139.7300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.8776
    Cell Significance Index: -40.1400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -2.2165
    Cell Significance Index: -70.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -2.2985
    Cell Significance Index: -119.4000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -2.4357
    Cell Significance Index: -157.1400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -2.5534
    Cell Significance Index: -83.6000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -2.6513
    Cell Significance Index: -84.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.7133
    Cell Significance Index: -171.0100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -2.9673
    Cell Significance Index: -85.0600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -3.5007
    Cell Significance Index: -92.0500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -3.5637
    Cell Significance Index: -62.9800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -3.5712
    Cell Significance Index: -125.1100
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -3.6326
    Cell Significance Index: -26.4100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -3.7167
    Cell Significance Index: -164.4000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -3.9041
    Cell Significance Index: -78.3800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -3.9713
    Cell Significance Index: -68.6700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -3.9812
    Cell Significance Index: -106.3100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -4.0006
    Cell Significance Index: -146.8600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -4.1231
    Cell Significance Index: -89.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NFIB is a member of the Nuclear Factor I (NFI) family of transcription factors, which are characterized by their ability to bind to specific DNA sequences and regulate gene expression. NFIB is specifically involved in the regulation of transcription by RNA polymerase II, a key enzyme responsible for transcribing protein-coding genes. NFIB's expression is tightly regulated by various transcriptional and post-transcriptional mechanisms, ensuring its precise temporal and spatial regulation during development and tissue homeostasis. **Pathways and Functions** NFIB's functions can be broadly categorized into several key pathways, including: 1. **Developmental Pathways**: NFIB is involved in the regulation of various developmental processes, including brain development, salivary gland development, and lung morphogenesis. Its expression is tightly regulated during embryonic development, and its dysregulation can lead to developmental abnormalities. 2. **Cell Differentiation**: NFIB plays a crucial role in the regulation of cell differentiation, particularly in the development of epithelial and neuronal cells. Its expression is required for the specification of cell fate and the maintenance of tissue homeostasis. 3. **Cell Proliferation**: NFIB is involved in the regulation of cell proliferation, particularly in the development of epithelial and immune cells. Its expression is required for the control of cell growth and differentiation during development and tissue homeostasis. 4. **Transcriptional Regulation**: NFIB is a transcriptional activator that regulates the expression of numerous genes involved in various cellular processes. Its ability to bind to specific DNA sequences and regulate gene expression ensures its precise temporal and spatial regulation during development and tissue homeostasis. **Clinical Significance** Dysregulation of NFIB has been implicated in various diseases and disorders, including: 1. **Neurodevelopmental Disorders**: NFIB's dysregulation has been linked to neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 2. **Cancer**: NFIB's dysregulation has been implicated in various types of cancer, including lung and breast cancer. 3. **Lung Disease**: NFIB's dysregulation has been linked to lung disease, including chronic obstructive pulmonary disease (COPD) and asthma. 4. **Immune Disorders**: NFIB's dysregulation has been implicated in immune disorders, including autoimmune diseases and immunodeficiency disorders. In conclusion, NFIB is a critical transcription factor that plays a central role in various developmental and physiological processes. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of its precise regulation during development and tissue homeostasis. Further study of NFIB's functions and dysregulation is necessary to understand its role in human disease and to develop effective therapeutic strategies.

Genular Protein ID: 1487668026

Symbol: NFIB_HUMAN

Name: Nuclear factor 1 B-type

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9484777

Title: Identification of NFIB as recurrent translocation partner gene of HMGIC in pleomorphic adenomas.

PubMed ID: 9484777

DOI: 10.1038/sj.onc.1201609

PubMed ID: 9099724

Title: NFI-B3, a novel transcriptional repressor of the nuclear factor I family, is generated by alternative RNA processing.

PubMed ID: 9099724

DOI: 10.1074/jbc.272.16.10739

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7590749

Title: Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH.

PubMed ID: 7590749

DOI: 10.1006/geno.1995.1107

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 31375868

Title: The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs.

PubMed ID: 31375868

DOI: 10.1007/s00018-019-03251-w

PubMed ID: 30388402

Title: NFIB haploinsufficiency is associated with intellectual disability and macrocephaly.

PubMed ID: 30388402

DOI: 10.1016/j.ajhg.2018.10.006

Sequence Information:

  • Length: 420
  • Mass: 47442
  • Checksum: 0F71635FE9D64FA4
  • Sequence:
  • MMYSPICLTQ DEFHPFIEAL LPHVRAIAYT WFNLQARKRK YFKKHEKRMS KDEERAVKDE 
    LLSEKPEIKQ KWASRLLAKL RKDIRQEYRE DFVLTVTGKK HPCCVLSNPD QKGKIRRIDC 
    LRQADKVWRL DLVMVILFKG IPLESTDGER LMKSPHCTNP ALCVQPHHIT VSVKELDLFL 
    AYYVQEQDSG QSGSPSHNDP AKNPPGYLED SFVKSGVFNV SELVRVSRTP ITQGTGVNFP 
    IGEIPSQPYY HDMNSGVNLQ RSLSSPPSSK RPKTISIDEN MEPSPTGDFY PSPSSPAAGS 
    RTWHERDQDM SSPTTMKKPE KPLFSSASPQ DSSPRLSTFP QHHHPGIPGV AHSVISTRTP 
    PPPSPLPFPT QAILPPAPSS YFSHPTIRYP PHLNPQDTLK NYVPSYDPSS PQTSQSWYLG

Genular Protein ID: 2727326291

Symbol: A0A0A0MRX8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 446
  • Mass: 50290
  • Checksum: 1EFD52F36D29368D
  • Sequence:
  • MERIPVSVDF WVVCCAVLKC NPGIPKRMST LCFGFSDEFH PFIEALLPHV RAIAYTWFNL 
    QARKRKYFKK HEKRMSKDEE RAVKDELLSE KPEIKQKWAS RLLAKLRKDI RQEYREDFVL 
    TVTGKKHPCC VLSNPDQKGK IRRIDCLRQA DKVWRLDLVM VILFKGIPLE STDGERLMKS 
    PHCTNPALCV QPHHITVSVK ELDLFLAYYV QEQDSGQSGS PSHNDPAKNP PGYLEDSFVK 
    SGVFNVSELV RVSRTPITQG TGVNFPIGEI PSQPYYHDMN SGVNLQRSLS SPPSSKRPKT 
    ISIDENMEPS PTGDFYPSPS SPAAGSRTWH ERDQDMSSPT TMKKPEKPLF SSASPQDSSP 
    RLSTFPQHHH PGIPGVAHSV ISTRTPPPPS PLPFPTQAIL PPAPSSYFSH PTIRYPPHLN 
    PQDTLKNYVP SYDPSSPQTS QSWYLG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.