Details for: TNNI1

Gene ID: 7135

Symbol: TNNI1

Ensembl ID: ENSG00000159173

Description: troponin I1, slow skeletal type

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 20.4830
    Cell Significance Index: 58.7000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 11.0282
    Cell Significance Index: 269.0800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.0544
    Cell Significance Index: 33.2100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.9596
    Cell Significance Index: 23.6300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.4831
    Cell Significance Index: 282.2400
  • Cell Name: secondary lymphoid organ macrophage (CL0000867)
    Fold Change: 1.1947
    Cell Significance Index: 8.7700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0556
    Cell Significance Index: 104.4300
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.0509
    Cell Significance Index: 9.0900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.9609
    Cell Significance Index: 7.6800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.6501
    Cell Significance Index: 10.4900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5289
    Cell Significance Index: 86.0200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4796
    Cell Significance Index: 52.1700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4137
    Cell Significance Index: 14.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2753
    Cell Significance Index: 19.0400
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.2113
    Cell Significance Index: 2.0500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1863
    Cell Significance Index: 11.1900
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.1805
    Cell Significance Index: 2.7000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1715
    Cell Significance Index: 3.5900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1590
    Cell Significance Index: 4.1800
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.1286
    Cell Significance Index: 1.2300
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.0982
    Cell Significance Index: 0.5800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0922
    Cell Significance Index: 4.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0868
    Cell Significance Index: 2.5000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0555
    Cell Significance Index: 0.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0342
    Cell Significance Index: 1.5500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0319
    Cell Significance Index: 0.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0238
    Cell Significance Index: 2.7700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0190
    Cell Significance Index: 0.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0162
    Cell Significance Index: 0.3500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0116
    Cell Significance Index: 0.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0073
    Cell Significance Index: 1.4600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0064
    Cell Significance Index: 0.2300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0047
    Cell Significance Index: 0.1300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0019
    Cell Significance Index: 1.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0006
    Cell Significance Index: 0.3200
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0004
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0021
    Cell Significance Index: -3.9000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0030
    Cell Significance Index: -5.5200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0038
    Cell Significance Index: -5.8100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0044
    Cell Significance Index: -5.9800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0056
    Cell Significance Index: -0.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0062
    Cell Significance Index: -4.5800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0070
    Cell Significance Index: -5.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0073
    Cell Significance Index: -5.4300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0083
    Cell Significance Index: -5.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0084
    Cell Significance Index: -1.5100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0093
    Cell Significance Index: -5.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0118
    Cell Significance Index: -5.3500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0128
    Cell Significance Index: -4.6000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0141
    Cell Significance Index: -0.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0174
    Cell Significance Index: -5.0000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0181
    Cell Significance Index: -0.2800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0223
    Cell Significance Index: -1.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0229
    Cell Significance Index: -4.6000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0236
    Cell Significance Index: -0.9700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0264
    Cell Significance Index: -5.5500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0277
    Cell Significance Index: -0.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0286
    Cell Significance Index: -4.8800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0294
    Cell Significance Index: -0.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0298
    Cell Significance Index: -3.6600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0337
    Cell Significance Index: -4.9000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0337
    Cell Significance Index: -4.6300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0408
    Cell Significance Index: -3.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0457
    Cell Significance Index: -5.2400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0481
    Cell Significance Index: -0.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0484
    Cell Significance Index: -5.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0490
    Cell Significance Index: -6.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0509
    Cell Significance Index: -5.3100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0522
    Cell Significance Index: -0.9000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0538
    Cell Significance Index: -1.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0540
    Cell Significance Index: -5.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0612
    Cell Significance Index: -4.8500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0639
    Cell Significance Index: -0.7300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0643
    Cell Significance Index: -1.3700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0722
    Cell Significance Index: -3.7600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0723
    Cell Significance Index: -1.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0786
    Cell Significance Index: -1.3200
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.0797
    Cell Significance Index: -0.6100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0811
    Cell Significance Index: -5.4500
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0844
    Cell Significance Index: -0.7200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0855
    Cell Significance Index: -6.3700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0882
    Cell Significance Index: -5.4100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0911
    Cell Significance Index: -5.8800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0937
    Cell Significance Index: -2.5100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0963
    Cell Significance Index: -5.9200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1016
    Cell Significance Index: -5.7000
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.1045
    Cell Significance Index: -0.6400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1074
    Cell Significance Index: -5.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1101
    Cell Significance Index: -4.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1177
    Cell Significance Index: -5.4900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1199
    Cell Significance Index: -2.9900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1233
    Cell Significance Index: -1.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1270
    Cell Significance Index: -5.9700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1280
    Cell Significance Index: -4.1000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1287
    Cell Significance Index: -2.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1302
    Cell Significance Index: -4.9300
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.1309
    Cell Significance Index: -0.5700
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1328
    Cell Significance Index: -1.2800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1490
    Cell Significance Index: -5.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TNNI1 is a slow skeletal type troponin I protein, which differs from the fast skeletal type troponin I. The slow skeletal type is primarily expressed in slow-twitch skeletal muscles, whereas the fast skeletal type is predominantly found in fast-twitch muscles. TNNI1 is a calcium-binding protein that interacts with troponin C and tropomyosin to regulate muscle contraction. Its slow skeletal type is characterized by a unique amino acid sequence and structural features that distinguish it from its fast skeletal counterpart. **Pathways and Functions:** TNNI1 is involved in various signaling pathways that regulate muscle contraction, including: 1. **Actin binding:** TNNI1 interacts with actin filaments to regulate muscle contraction. 2. **Cardiac muscle contraction:** TNNI1 plays a critical role in regulating cardiac muscle contraction, particularly in the fast-twitch cardiac muscle cells. 3. **Cytosol:** TNNI1 is involved in regulating cytosolic calcium levels, which is essential for muscle contraction. 4. **Muscle contraction:** TNNI1 regulates muscle contraction by interacting with troponin C and tropomyosin to modulate the interaction between actin and myosin. 5. **Regulation of striated muscle contraction:** TNNI1 is essential for regulating striated muscle contraction in skeletal and cardiac muscles. 6. **Transition between fast and slow fiber:** TNNI1 is involved in regulating the transition between fast-twitch and slow-twitch muscle fibers. 7. **Troponin complex:** TNNI1 is a key component of the troponin complex, which regulates muscle contraction. **Clinical Significance:** Dysregulation of TNNI1 has been implicated in various diseases, including: 1. **Muscular dystrophy:** Mutations in the TNNI1 gene have been associated with muscular dystrophy, a group of genetic disorders characterized by progressive muscle weakness and degeneration. 2. **Cardiac arrhythmias:** Abnormalities in TNNI1 expression have been linked to cardiac arrhythmias, including atrial fibrillation and ventricular tachycardia. 3. **Skeletal muscle disorders:** TNNI1 mutations have been associated with skeletal muscle disorders, including myopathies and muscle weakness. 4. **Cancer:** TNNI1 has been implicated in cancer development and progression, particularly in colon cancer and other epithelial cancers. In conclusion, TNNI1 is a critical protein component of the troponin complex, essential for regulating muscle contraction in skeletal and cardiac muscles. Its dysregulation has been implicated in various diseases, highlighting the importance of TNNI1 in maintaining muscle function and integrity. Further research is needed to elucidate the mechanisms underlying TNNI1 dysfunction and to develop effective therapeutic strategies for diseases associated with TNNI1 abnormalities.

Genular Protein ID: 2958874039

Symbol: TNNI1_HUMAN

Name: Troponin I, slow skeletal muscle

UniProtKB Accession Codes:

P19237 A6NEH3 A8MSJ0 Q659A5 Q6FGS7 Q6FGW1 Q6ICU2 Q86T57 Q96DT9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 17 Ensembl 3 ExpressionAtlas 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2365354

Title: cDNA sequence, tissue-specific expression, and chromosomal mapping of the human slow-twitch skeletal muscle isoform of troponin I.

PubMed ID: 2365354

DOI: 10.1016/0888-7543(90)90168-t

PubMed ID: 8144655

Title: Structure and expression of the human slow twitch skeletal muscle troponin I gene.

PubMed ID: 8144655

DOI: 10.1016/s0021-9258(17)34109-1

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 187
  • Mass: 21692
  • Checksum: 7A8363CC7559B962
  • Sequence:
    • MPEVERKPKI TASRKLLLKS LMLAKAKECW EQEHEEREAE KVRYLAERIP TLQTRGLSLS 
ALQDLCRELH AKVEVVDEER YDIEAKCLHN TREIKDLKLK VMDLRGKFKR PPLRRVRVSA 
DAMLRALLGS KHKVSMDLRA NLKSVKKEDT EKERPVEVGD WRKNVEAMSG MEGRKKMFDA 
AKSPTSQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.