Details for: TNNI1

Gene ID: 7135

Symbol: TNNI1

Ensembl ID: ENSG00000159173

Description: troponin I1, slow skeletal type

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 5.46
    Marker Score: 4157
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.85
    Marker Score: 1267
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.7
    Marker Score: 710
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1165
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.48
    Marker Score: 3492
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 865
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.26
    Marker Score: 321
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.17
    Marker Score: 1241
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.13
    Marker Score: 17756
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.11
    Marker Score: 356
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.02
    Marker Score: 1938
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71817
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48042
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.98
    Marker Score: 661
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.96
    Marker Score: 399
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5277
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.92
    Marker Score: 12202
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1259
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 309
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.77
    Marker Score: 506
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 685
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 553
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3028
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.72
    Marker Score: 1685
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.69
    Marker Score: 462
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.61
    Marker Score: 1274
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.58
    Marker Score: 370.5
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.58
    Marker Score: 334
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.56
    Marker Score: 250
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 446
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.56
    Marker Score: 315
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.54
    Marker Score: 1105
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.51
    Marker Score: 205
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.5
    Marker Score: 564
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.48
    Marker Score: 126
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.48
    Marker Score: 808
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.47
    Marker Score: 148
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 275
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.45
    Marker Score: 164
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.45
    Marker Score: 147
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.42
    Marker Score: 155
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.42
    Marker Score: 199
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.4
    Marker Score: 118
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.39
    Marker Score: 206
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.39
    Marker Score: 454
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 369
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.34
    Marker Score: 207
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.34
    Marker Score: 80
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.32
    Marker Score: 2138
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.3
    Marker Score: 96
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.28
    Marker Score: 130
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.28
    Marker Score: 3655
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.28
    Marker Score: 68
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.27
    Marker Score: 112
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.27
    Marker Score: 189
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.26
    Marker Score: 171
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.23
    Marker Score: 88
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.23
    Marker Score: 73
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.21
    Marker Score: 239
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.21
    Marker Score: 67
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.21
    Marker Score: 200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.2
    Marker Score: 62
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.19
    Marker Score: 1902
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.19
    Marker Score: 57
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.19
    Marker Score: 67
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.18
    Marker Score: 1196
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.18
    Marker Score: 280
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.18
    Marker Score: 83
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.18
    Marker Score: 104
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.18
    Marker Score: 46
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.17
    Marker Score: 84
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.16
    Marker Score: 40
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.16
    Marker Score: 150
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.15
    Marker Score: 31
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.15
    Marker Score: 146
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.15
    Marker Score: 146
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.15
    Marker Score: 51
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.15
    Marker Score: 66
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.15
    Marker Score: 241
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.15
    Marker Score: 100
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.14
    Marker Score: 446
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.14
    Marker Score: 146
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.13
    Marker Score: 76
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.13
    Marker Score: 83
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.13
    Marker Score: 117
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.13
    Marker Score: 45
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.13
    Marker Score: 138
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.13
    Marker Score: 32

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Other Information

**Key Characteristics:** TNNI1 is a slow skeletal type troponin I protein, which differs from the fast skeletal type troponin I. The slow skeletal type is primarily expressed in slow-twitch skeletal muscles, whereas the fast skeletal type is predominantly found in fast-twitch muscles. TNNI1 is a calcium-binding protein that interacts with troponin C and tropomyosin to regulate muscle contraction. Its slow skeletal type is characterized by a unique amino acid sequence and structural features that distinguish it from its fast skeletal counterpart. **Pathways and Functions:** TNNI1 is involved in various signaling pathways that regulate muscle contraction, including: 1. **Actin binding:** TNNI1 interacts with actin filaments to regulate muscle contraction. 2. **Cardiac muscle contraction:** TNNI1 plays a critical role in regulating cardiac muscle contraction, particularly in the fast-twitch cardiac muscle cells. 3. **Cytosol:** TNNI1 is involved in regulating cytosolic calcium levels, which is essential for muscle contraction. 4. **Muscle contraction:** TNNI1 regulates muscle contraction by interacting with troponin C and tropomyosin to modulate the interaction between actin and myosin. 5. **Regulation of striated muscle contraction:** TNNI1 is essential for regulating striated muscle contraction in skeletal and cardiac muscles. 6. **Transition between fast and slow fiber:** TNNI1 is involved in regulating the transition between fast-twitch and slow-twitch muscle fibers. 7. **Troponin complex:** TNNI1 is a key component of the troponin complex, which regulates muscle contraction. **Clinical Significance:** Dysregulation of TNNI1 has been implicated in various diseases, including: 1. **Muscular dystrophy:** Mutations in the TNNI1 gene have been associated with muscular dystrophy, a group of genetic disorders characterized by progressive muscle weakness and degeneration. 2. **Cardiac arrhythmias:** Abnormalities in TNNI1 expression have been linked to cardiac arrhythmias, including atrial fibrillation and ventricular tachycardia. 3. **Skeletal muscle disorders:** TNNI1 mutations have been associated with skeletal muscle disorders, including myopathies and muscle weakness. 4. **Cancer:** TNNI1 has been implicated in cancer development and progression, particularly in colon cancer and other epithelial cancers. In conclusion, TNNI1 is a critical protein component of the troponin complex, essential for regulating muscle contraction in skeletal and cardiac muscles. Its dysregulation has been implicated in various diseases, highlighting the importance of TNNI1 in maintaining muscle function and integrity. Further research is needed to elucidate the mechanisms underlying TNNI1 dysfunction and to develop effective therapeutic strategies for diseases associated with TNNI1 abnormalities.

Genular Protein ID: 2958874039

Symbol: TNNI1_HUMAN

Name: Troponin I, slow skeletal muscle

UniProtKB Accession Codes:

P19237 A6NEH3 A8MSJ0 Q659A5 Q6FGS7 Q6FGW1 Q6ICU2 Q86T57 Q96DT9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 17 Ensembl 3 ExpressionAtlas 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2365354

Title: cDNA sequence, tissue-specific expression, and chromosomal mapping of the human slow-twitch skeletal muscle isoform of troponin I.

PubMed ID: 2365354

DOI: 10.1016/0888-7543(90)90168-t

PubMed ID: 8144655

Title: Structure and expression of the human slow twitch skeletal muscle troponin I gene.

PubMed ID: 8144655

DOI: 10.1016/s0021-9258(17)34109-1

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 187
  • Mass: 21692
  • Checksum: 7A8363CC7559B962
  • Sequence:
    • MPEVERKPKI TASRKLLLKS LMLAKAKECW EQEHEEREAE KVRYLAERIP TLQTRGLSLS 
ALQDLCRELH AKVEVVDEER YDIEAKCLHN TREIKDLKLK VMDLRGKFKR PPLRRVRVSA 
DAMLRALLGS KHKVSMDLRA NLKSVKKEDT EKERPVEVGD WRKNVEAMSG MEGRKKMFDA 
AKSPTSQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.