Details for: SOX6
Gene ID: 55553
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: SOX6
Ensembl ID: ENSG00000110693
Description: SRY-box transcription factor 6
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 51.86rCSI 64.52%PRS 62.09
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CSI 50.75rCSI 65.43%PRS 65.39
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CSI 41.01rCSI 74.52%PRS 73.47
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CSI 40.53rCSI 58.15%PRS 71.68
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CSI 36.15rCSI 79.54%PRS 63.89
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CSI 36.12rCSI 73.3%PRS 60.53
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CSI 32.35rCSI 44.26%PRS 73.11
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CSI 23.32rCSI 31.86%PRS 81.2
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CSI 22.68rCSI 52.36%PRS 69.96
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CSI 22.49rCSI 37.76%PRS 64.23
-
CSI 22.18rCSI 31.43%PRS 78.51
-
CSI 21.01rCSI 44.76%PRS 57.45
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CSI 20.44rCSI 45.83%PRS 65.03
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CSI 20.21rCSI 51.26%PRS 72.36
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CSI 20.01rCSI 25.69%PRS 72.07
-
CSI 18.87rCSI 59.01%PRS 68.2
-
CSI 17.06rCSI 45.59%PRS 73.7
-
CSI 14.79rCSI 47.32%PRS 79.2
-
CSI 14.5rCSI 32.9%PRS 82
-
CSI 14.29rCSI 23.39%PRS 71.49
-
CSI 14rCSI 13.48%PRS 80.98
-
CSI 13.51rCSI 21.54%PRS 73.32
-
CSI 13.08rCSI 18.11%PRS 78.62
-
CSI 12.13rCSI 33.43%PRS 76.93
-
CSI 11.34rCSI 21.24%PRS 70.36
-
CSI 10.96rCSI 16.75%PRS 85.03
-
CSI 10.74rCSI 9.45%PRS 71.17
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CSI 10.71rCSI 40.42%PRS 65.11
-
CSI 10.4rCSI 20.87%PRS 72.45
-
CSI 10.38rCSI 30.63%PRS 82.56
-
CSI 10.04rCSI 22.11%PRS 85.18
-
CSI 9.25rCSI 7.31%PRS 71.04
-
CSI 9.14rCSI 22.33%PRS 74.05
-
CSI 8.87rCSI 28.56%PRS 78.47
-
CSI 8.65rCSI 12.02%PRS 80.02
-
CSI 8.47rCSI 12.14%PRS 81.94
-
CSI 8.42rCSI 44.27%PRS 82.92
-
CSI 8.32rCSI 41.85%PRS 78.83
-
CSI 8.13rCSI 62.96%PRS 75.38
-
CSI 8.06rCSI 16.57%PRS 69.07
-
CSI 8rCSI 19.07%PRS 81.66
-
CSI 7.92rCSI 12.77%PRS 80.5
-
CSI 7.8rCSI 20.33%PRS 82.78
-
CSI 7.71rCSI 51.15%PRS 76.24
-
CSI 7.29rCSI 21.11%PRS 81.04
-
CSI 7.22rCSI 24.2%PRS 65.76
-
CSI 7.07rCSI 26.48%PRS 74.44
-
CSI 6.87rCSI 68.64%PRS 40.23
-
CSI 6.67rCSI 4.94%PRS 75.46
-
CSI 6.48rCSI 7.49%PRS 73.93
-
CSI 6.45rCSI 8.02%PRS 82.35
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CSI 6.43rCSI 10.22%PRS 75.05
-
CSI 6.36rCSI 18.07%PRS 77.34
-
CSI 6.09rCSI 27.07%PRS 82.17
-
CSI 5.78rCSI 10%PRS 73.61
-
CSI 5.77rCSI 14.93%PRS 77.21
-
CSI 5.7rCSI 15.04%PRS 87.81
-
CSI 5.63rCSI 40.19%PRS 79.32
-
CSI 5.51rCSI 31.79%PRS 78.21
-
CSI 5.49rCSI 62.84%PRS 69.8
-
CSI 5.41rCSI 8.4%PRS 85.12
-
CSI 5.39rCSI 27.62%PRS 84.49
-
CSI 5.35rCSI 20.81%PRS 80.75
-
CSI 5.27rCSI 12.03%PRS 73.33
-
CSI 5.2rCSI 11.89%PRS 82.4
-
CSI 5.16rCSI 4.33%PRS 84.12
-
CSI 5.13rCSI 5.62%PRS 83.52
-
CSI 5.12rCSI 20%PRS 77.68
-
CSI 4.99rCSI 6.68%PRS 80.01
-
CSI 4.97rCSI 20.04%PRS 81.59
-
CSI 4.87rCSI 30.42%PRS 73.61
-
CSI 4.77rCSI 22.83%PRS 78.05
-
CSI 4.72rCSI 17.98%PRS 73.03
-
CSI 4.7rCSI 4.91%PRS 79.18
-
CSI 4.66rCSI 4.99%PRS 83.01
-
CSI 4.64rCSI 22.22%PRS 81.65
-
CSI 4.59rCSI 27.49%PRS 83.31
-
CSI 4.52rCSI 6.72%PRS 81.3
-
CSI 4.37rCSI 11.1%PRS 75.29
-
CSI 4.25rCSI 18.06%PRS 74.03
-
CSI 4.04rCSI 13.13%PRS 79.37
-
CSI 3.87rCSI 8.82%PRS 75.22
-
CSI 3.86rCSI 6.81%PRS 86.34
-
CSI 3.66rCSI 8.59%PRS 81.35
-
CSI 3.64rCSI 17.11%PRS 73.07
-
CSI 3.57rCSI 15.72%PRS 70.23
-
CSI 3.57rCSI 5.27%PRS 90.65
-
CSI 3.46rCSI 10.21%PRS 80.63
-
CSI 3.3rCSI 18.37%PRS 84.39
-
CSI 3.27rCSI 3.04%PRS 82.42
-
CSI 3.14rCSI 7.53%PRS 84.77
-
CSI 3.03rCSI 5.69%PRS 87.83
-
CSI 3.03rCSI 7.88%PRS 81.98
-
CSI 3.02rCSI 7.87%PRS 79.93
-
CSI 3rCSI 4.1%PRS 83.08
-
CSI 2.99rCSI 3.1%PRS 85.32
-
CSI 2.99rCSI 2.88%PRS 75.37
-
CSI 2.93rCSI 7.89%PRS 85.8
-
CSI 2.87rCSI 5.13%PRS 80.85
-
CSI 2.74rCSI 3.27%PRS 64.34
-
CSI 0.3rCSI 6.6%PRS 72.7%
-
CSI 0.5rCSI 2.7%PRS 85.1%
-
CSI 0.5rCSI 7.7%PRS 88.6%
-
CSI 0.8rCSI 1.5%PRS 84.4%
-
CSI 0.9rCSI 5.1%PRS 88.5%
-
CSI 1.0rCSI 3.9%PRS 88.0%
-
CSI 1.0rCSI 3.5%PRS 62.2%
-
CSI 1.0rCSI 4.8%PRS 89.0%
-
CSI 1.0rCSI 11.3%PRS 87.8%
-
CSI 1.0rCSI 4.6%PRS 88.6%
-
CSI 1.1rCSI 7.8%PRS 74.8%
-
CSI 1.1rCSI 3.1%PRS 87.9%
-
CSI 1.2rCSI 7.5%PRS 77.5%
-
CSI 1.4rCSI 3.6%PRS 86.6%
-
CSI 1.5rCSI 6.8%PRS 90.6%
-
CSI 1.6rCSI 3.5%PRS 81.0%
-
CSI 1.7rCSI 2.7%PRS 65.7%
-
CSI 1.7rCSI 4.9%PRS 76.8%
-
CSI 1.8rCSI 4.6%PRS 87.9%
-
CSI 1.9rCSI 2.8%PRS 81.7%
-
CSI 1.9rCSI 2.6%PRS 86.6%
-
CSI 1.9rCSI 4.3%PRS 88.4%
-
CSI 2.0rCSI 7.9%PRS 89.2%
-
CSI 2.1rCSI 13.2%PRS 89.4%
-
CSI 2.1rCSI 4.2%PRS 89.7%
-
CSI 2.1rCSI 2.0%PRS 84.0%
-
CSI 2.1rCSI 6.0%PRS 71.4%
-
CSI 2.1rCSI 5.1%PRS 84.4%
-
CSI 2.1rCSI 6.8%PRS 83.1%
-
CSI 2.2rCSI 3.8%PRS 63.7%
-
CSI 2.2rCSI 23.2%PRS 77.7%
-
CSI 2.3rCSI 8.2%PRS 85.3%
-
CSI 2.3rCSI 9.0%PRS 60.3%
-
CSI 2.3rCSI 2.4%PRS 84.6%
-
CSI 2.4rCSI 5.2%PRS 67.8%
-
CSI 2.4rCSI 2.8%PRS 74.2%
-
CSI 2.5rCSI 20.1%PRS 76.2%
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CSI 2.5rCSI 5.0%PRS 77.4%
-
CSI 2.5rCSI 5.5%PRS 86.5%
-
CSI 2.6rCSI 22.6%PRS 76.0%
-
CSI 2.7rCSI 7.0%PRS 78.3%
-
CSI 2.7rCSI 6.8%PRS 81.7%
-
CSI 2.7rCSI 3.3%PRS 64.3%
-
CSI 2.9rCSI 5.1%PRS 80.9%
-
CSI 2.9rCSI 7.9%PRS 85.8%
-
CSI 3.0rCSI 2.9%PRS 75.4%
-
CSI 3.0rCSI 3.1%PRS 85.3%
-
CSI 3.0rCSI 4.1%PRS 83.1%
-
CSI 3.0rCSI 7.9%PRS 79.9%
-
CSI 3.0rCSI 7.9%PRS 82.0%
-
CSI 3.0rCSI 5.7%PRS 87.8%
-
CSI 3.1rCSI 7.5%PRS 84.8%
-
CSI 3.3rCSI 3.0%PRS 82.4%
-
CSI 3.3rCSI 18.4%PRS 84.4%
-
CSI 3.5rCSI 10.2%PRS 80.6%
-
CSI 3.6rCSI 5.3%PRS 90.7%
-
CSI 3.6rCSI 15.7%PRS 70.2%
-
CSI 3.6rCSI 17.1%PRS 73.1%
-
CSI 3.7rCSI 8.6%PRS 81.4%
-
CSI 3.9rCSI 6.8%PRS 86.3%
-
CSI 3.9rCSI 8.8%PRS 75.2%
-
CSI 4.0rCSI 13.1%PRS 79.4%
-
CSI 4.3rCSI 18.1%PRS 74.0%
-
CSI 4.4rCSI 11.1%PRS 75.3%
-
CSI 4.5rCSI 6.7%PRS 81.3%
-
CSI 4.6rCSI 27.5%PRS 83.3%
-
CSI 4.6rCSI 22.2%PRS 81.7%
-
CSI 4.7rCSI 5.0%PRS 83.0%
-
CSI 4.7rCSI 4.9%PRS 79.2%
-
CSI 4.7rCSI 18.0%PRS 73.0%
-
CSI 4.8rCSI 22.8%PRS 78.1%
-
CSI 4.9rCSI 30.4%PRS 73.6%
-
CSI 5.0rCSI 20.0%PRS 81.6%
-
CSI 5.0rCSI 6.7%PRS 80.0%
-
CSI 5.1rCSI 20.0%PRS 77.7%
-
CSI 5.1rCSI 5.6%PRS 83.5%
-
CSI 5.2rCSI 4.3%PRS 84.1%
-
CSI 5.2rCSI 11.9%PRS 82.4%
-
CSI 5.3rCSI 12.0%PRS 73.3%
-
CSI 5.4rCSI 20.8%PRS 80.8%
-
CSI 5.4rCSI 27.6%PRS 84.5%
-
CSI 5.4rCSI 8.4%PRS 85.1%
-
CSI 5.5rCSI 62.8%PRS 69.8%
-
CSI 5.5rCSI 31.8%PRS 78.2%
-
CSI 5.6rCSI 40.2%PRS 79.3%
-
CSI 5.7rCSI 15.0%PRS 87.8%
-
CSI 5.8rCSI 14.9%PRS 77.2%
-
CSI 5.8rCSI 10.0%PRS 73.6%
-
CSI 6.1rCSI 27.1%PRS 82.2%
-
CSI 6.4rCSI 18.1%PRS 77.3%
-
CSI 6.4rCSI 10.2%PRS 75.1%
-
CSI 6.5rCSI 8.0%PRS 82.4%
-
CSI 6.5rCSI 7.5%PRS 73.9%
-
CSI 6.7rCSI 4.9%PRS 75.5%
-
CSI 6.9rCSI 68.6%PRS 40.2%
-
CSI 7.1rCSI 26.5%PRS 74.4%
-
CSI 7.2rCSI 24.2%PRS 65.8%
-
CSI 7.3rCSI 21.1%PRS 81.0%
-
CSI 7.7rCSI 51.2%PRS 76.2%
-
CSI 7.8rCSI 20.3%PRS 82.8%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 358693696
Symbol: SOX6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11255018
Title: Cloning, characterization and chromosome mapping of the human SOX6 gene.
PubMed ID: 11255018
PubMed ID: 11230166
Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
PubMed ID: 11230166
DOI: 10.1101/gr.gr1547r
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1614875
Title: A conserved family of genes related to the testis determining gene, SRY.
PubMed ID: 1614875
PubMed ID: 16442531
Title: Repression of SOX6 transcriptional activity by SUMO modification.
PubMed ID: 16442531
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 32442410
Title: De Novo SOX6 Variants Cause a Neurodevelopmental Syndrome Associated with ADHD, Craniosynostosis, and Osteochondromas.
PubMed ID: 32442410
Sequence Information:
- Length: 828
- Mass: 91921
- Checksum: 38CA781528C839CF
- Sequence:
MSSKQATSPF ACAADGEDAM TQDLTSREKE EGSDQHVASH LPLHPIMHNK PHSEELPTLV STIQQDADWD SVLSSQQRME SENNKLCSLY SFRNTSTSPH KPDEGSRDRE IMTSVTFGTP ERRKGSLADV VDTLKQKKLE EMTRTEQEDS SCMEKLLSKD WKEKMERLNT SELLGEIKGT PESLAEKERQ LSTMITQLIS LREQLLAAHD EQKKLAASQI EKQRQQMDLA RQQQEQIARQ QQQLLQQQHK INLLQQQIQV QGHMPPLMIP IFPHDQRTLA AAAAAQQGFL FPPGITYKPG DNYPVQFIPS TMAAAAASGL SPLQLQKGHV SHPQINQRLK GLSDRFGRNL DTFEHGGGHS YNHKQIEQLY AAQLASMQVS PGAKMPSTPQ PPNTAGTVSP TGIKNEKRGT SPVTQVKDEA AAQPLNLSSR PKTAEPVKSP TSPTQNLFPA SKTSPVNLPN KSSIPSPIGG SLGRGSSLDI LSSLNSPALF GDQDTVMKAI QEARKMREQI QREQQQQQPH GVDGKLSSIN NMGLNSCRNE KERTRFENLG PQLTGKSNED GKLGPGVIDL TRPEDAEGSK AMNGSAAKLQ QYYCWPTGGA TVAEARVYRD ARGRASSEPH IKRPMNAFMV WAKDERRKIL QAFPDMHNSN ISKILGSRWK SMSNQEKQPY YEEQARLSKI HLEKYPNYKY KPRPKRTCIV DGKKLRIGEY KQLMRSRRQE MRQFFTVGQQ PQIPITTGTG VVYPGAITMA TTTPSPQMTS DCSSTSASPE PSLPVIQSTY GMKTDGGSLA GNEMINGEDE MEMYDDYEDD PKSDYSSENE APEAVSAN