Details for: TNNC2

Gene ID: 7125

Symbol: TNNC2

Ensembl ID: ENSG00000101470

Description: troponin C2, fast skeletal type

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 32.6593
    Cell Significance Index: -5.0800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 19.0031
    Cell Significance Index: -4.8200
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 17.1129
    Cell Significance Index: 276.1200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 10.2258
    Cell Significance Index: -5.2600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 7.4811
    Cell Significance Index: -5.0200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.1121
    Cell Significance Index: -5.0700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 3.4403
    Cell Significance Index: 83.9400
  • Cell Name: secondary lymphoid organ macrophage (CL0000867)
    Fold Change: 3.0378
    Cell Significance Index: 22.3000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.0195
    Cell Significance Index: -5.4100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.2950
    Cell Significance Index: -5.1100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2288
    Cell Significance Index: 73.7700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2243
    Cell Significance Index: 133.1700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.1935
    Cell Significance Index: 12.9800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.0785
    Cell Significance Index: 16.1600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0101
    Cell Significance Index: 164.2900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9422
    Cell Significance Index: 850.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6967
    Cell Significance Index: 31.5800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6715
    Cell Significance Index: 66.4300
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.3717
    Cell Significance Index: 3.8800
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.3054
    Cell Significance Index: 4.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2200
    Cell Significance Index: 41.8700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1978
    Cell Significance Index: 6.9500
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.1864
    Cell Significance Index: 2.0200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.1855
    Cell Significance Index: 1.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1843
    Cell Significance Index: 5.3100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1821
    Cell Significance Index: 1.8900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1598
    Cell Significance Index: 2.5400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1597
    Cell Significance Index: 4.2000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1426
    Cell Significance Index: 3.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1139
    Cell Significance Index: 22.8400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0845
    Cell Significance Index: 1.8000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0696
    Cell Significance Index: 1.7900
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.0515
    Cell Significance Index: 0.7700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0468
    Cell Significance Index: 1.5000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0358
    Cell Significance Index: 0.7500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0347
    Cell Significance Index: 0.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0326
    Cell Significance Index: 11.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0237
    Cell Significance Index: 1.0500
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.0226
    Cell Significance Index: 0.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0217
    Cell Significance Index: 11.8700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0197
    Cell Significance Index: 2.3000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0120
    Cell Significance Index: 1.4200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0092
    Cell Significance Index: 0.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0050
    Cell Significance Index: 0.6900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0048
    Cell Significance Index: 0.1800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0030
    Cell Significance Index: 0.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0027
    Cell Significance Index: 1.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0009
    Cell Significance Index: 0.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0009
    Cell Significance Index: 1.7700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0017
    Cell Significance Index: -3.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0020
    Cell Significance Index: -3.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0030
    Cell Significance Index: -4.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0031
    Cell Significance Index: -0.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0049
    Cell Significance Index: -3.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0056
    Cell Significance Index: -4.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0061
    Cell Significance Index: -4.5000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0066
    Cell Significance Index: -4.8600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0082
    Cell Significance Index: -4.6200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0086
    Cell Significance Index: -1.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0089
    Cell Significance Index: -4.0500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0090
    Cell Significance Index: -0.2400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0090
    Cell Significance Index: -1.1600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0119
    Cell Significance Index: -0.1000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0121
    Cell Significance Index: -0.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0141
    Cell Significance Index: -4.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0155
    Cell Significance Index: -1.9100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0170
    Cell Significance Index: -2.4700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0200
    Cell Significance Index: -0.9400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0212
    Cell Significance Index: -1.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0240
    Cell Significance Index: -5.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0252
    Cell Significance Index: -4.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0258
    Cell Significance Index: -0.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0298
    Cell Significance Index: -3.0400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0311
    Cell Significance Index: -1.9600
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0338
    Cell Significance Index: -0.2100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0352
    Cell Significance Index: -1.6400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0372
    Cell Significance Index: -4.2600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0398
    Cell Significance Index: -0.5700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0421
    Cell Significance Index: -2.8300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0432
    Cell Significance Index: -2.2700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0435
    Cell Significance Index: -3.0800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0465
    Cell Significance Index: -0.7000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0483
    Cell Significance Index: -5.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0601
    Cell Significance Index: -4.6100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0611
    Cell Significance Index: -4.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0618
    Cell Significance Index: -3.7900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0639
    Cell Significance Index: -4.7600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0677
    Cell Significance Index: -4.1600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0704
    Cell Significance Index: -1.7600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0747
    Cell Significance Index: -3.8900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0760
    Cell Significance Index: -3.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0766
    Cell Significance Index: -4.9400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0774
    Cell Significance Index: -2.6900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0844
    Cell Significance Index: -2.4200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0844
    Cell Significance Index: -1.7500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0845
    Cell Significance Index: -2.6900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0877
    Cell Significance Index: -4.9200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0881
    Cell Significance Index: -3.0900
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0931
    Cell Significance Index: -0.8200
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.0943
    Cell Significance Index: -1.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Isoform specificity**: TNNC2 is a fast skeletal isoform, distinct from its slow skeletal and cardiac isoforms, which have different regulatory properties. 2. **Calcium ion binding**: TNNC2 is known for its high affinity for calcium ions, which is essential for muscle contraction regulation. 3. **Protein interactions**: TNNC2 interacts with tropomyosin, actin, and troponin T to form the troponin complex, regulating muscle contraction. 4. **Expression in various tissues**: TNNC2 is highly expressed in skeletal muscle, enterocytes, kidney proximal convoluted tubule epithelial cells, and other tissues, indicating its wide-ranging roles. **Pathways and Functions:** 1. **Muscle contraction regulation**: TNNC2 plays a crucial role in regulating muscle contraction by binding to calcium ions and interacting with tropomyosin and actin. 2. **Actin binding**: TNNC2 binds to actin, which is essential for muscle contraction and relaxation. 3. **Calcium ion binding**: TNNC2 has a high affinity for calcium ions, which is necessary for muscle contraction regulation. 4. **Regulation of muscle contraction**: TNNC2, along with tropomyosin and troponin T, regulates muscle contraction by controlling the interaction between actin and myosin. **Clinical Significance:** 1. **Muscle disorders**: Mutations in the TNNC2 gene have been associated with muscle disorders, such as hypertrophic cardiomyopathy and skeletal muscle disorders. 2. **Muscle fatigue**: Abnormalities in TNNC2 expression and function may contribute to muscle fatigue and weakness in various conditions. 3. **Neurological disorders**: TNNC2 has been implicated in neurological disorders, such as epilepsy and autism, where disruptions in calcium ion homeostasis and muscle contraction regulation may play a role. 4. **Cancer**: TNNC2 expression has been observed in various types of cancer, including colon cancer, suggesting its potential role in cancer progression and metastasis. In conclusion, TNNC2 is a critical component of the troponin complex, regulating muscle contraction in skeletal muscle. Its unique characteristics, pathways, and functions highlight its importance in maintaining muscle homeostasis and overall health. Further research is necessary to fully elucidate the role of TNNC2 in various diseases and to explore its potential as a therapeutic target.

Genular Protein ID: 3484108681

Symbol: TNNC2_HUMAN

Name: Troponin C, skeletal muscle

UniProtKB Accession Codes:

P02585 Q6FH92

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 19 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 10 Ensembl 1 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3166492

Title: Differential expression of slow and fast skeletal muscle troponin C. Slow skeletal muscle troponin C is expressed in human fibroblasts.

PubMed ID: 3166492

DOI: 10.1016/0022-2836(88)90145-3

PubMed ID: 2373703

Title: Cloning, structural analysis, and expression of the human fast twitch skeletal muscle troponin C gene.

PubMed ID: 2373703

DOI: 10.1016/s0021-9258(19)38376-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 978749

Title: Human skeletal muscle proteins. The primary structure of troponin C.

PubMed ID: 978749

DOI: 10.1007/bf01730999

PubMed ID: 33755597

Title: Pathogenic variants in TNNC2 cause congenital myopathy due to an impaired force response to calcium.

PubMed ID: 33755597

DOI: 10.1172/jci145700

Sequence Information:

  • Length: 160
  • Mass: 18122
  • Checksum: EA93729732A0F916
  • Sequence:
    • MTDQQAEARS YLSEEMIAEF KAAFDMFDAD GGGDISVKEL GTVMRMLGQT PTKEELDAII 
EEVDEDGSGT IDFEEFLVMM VRQMKEDAKG KSEEELAECF RIFDRNADGY IDPEELAEIF 
RASGEHVTDE EIESLMKDGD KNNDGRIDFD EFLKMMEGVQ

Genular Protein ID: 3795363840

Symbol: C9J7T9_HUMAN

Name: N/A

UniProtKB Accession Codes:

C9J7T9

Database IDs:

ARBA 4 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 GO 1 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 IntAct 1 InterPro 4 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 145
  • Mass: 16382
  • Checksum: AAD72C6EBC4CFFF2
  • Sequence:
    • MIAEFKAAFD MFDADGGGDI SVKELGTVMR MLGQTPTKEE LDAIIEEVDE DGSGTIDFEE 
FLVMMVRQMK EDAKGKSEEE LAECFRIFDR NADGYIDPEE LAEIFRASGE HVTDEEIESL 
MKDGDKNNDG RIDFDEFLKM MEGVQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.