Details for: TNNC2

Gene ID: 7125

Symbol: TNNC2

Ensembl ID: ENSG00000101470

Description: troponin C2, fast skeletal type

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 8.72
    Marker Score: 6631.5
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.83
    Marker Score: 2827
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.53
    Marker Score: 3160
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.1
    Marker Score: 1051
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71824.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48049
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5324
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.91
    Marker Score: 4390
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2736
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.88
    Marker Score: 3390
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8
    Marker Score: 12504
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 684
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.71
    Marker Score: 546
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.7
    Marker Score: 279
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.7
    Marker Score: 2185
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.69
    Marker Score: 218
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.66
    Marker Score: 314
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.66
    Marker Score: 198
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.65
    Marker Score: 1223
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.58
    Marker Score: 1173
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 232
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.55
    Marker Score: 1561
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 439
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.55
    Marker Score: 159
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.54
    Marker Score: 203
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.5
    Marker Score: 333
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.48
    Marker Score: 518
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.41
    Marker Score: 299
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.38
    Marker Score: 119
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.38
    Marker Score: 892
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.36
    Marker Score: 115
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.35
    Marker Score: 2107
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.35
    Marker Score: 829
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.34
    Marker Score: 524
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.34
    Marker Score: 78
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.33
    Marker Score: 400.5
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.32
    Marker Score: 106
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.32
    Marker Score: 1892
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.31
    Marker Score: 82
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.3
    Marker Score: 136
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.29
    Marker Score: 1946
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.28
    Marker Score: 77
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.28
    Marker Score: 963
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.27
    Marker Score: 188
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.27
    Marker Score: 123
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.26
    Marker Score: 113
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.25
    Marker Score: 66
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.24
    Marker Score: 70
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.24
    Marker Score: 63
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.24
    Marker Score: 78
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.24
    Marker Score: 147
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.24
    Marker Score: 61
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.23
    Marker Score: 56
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.23
    Marker Score: 146
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.22
    Marker Score: 271
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.22
    Marker Score: 221
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.21
    Marker Score: 231
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.21
    Marker Score: 247
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.21
    Marker Score: 141
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2
    Marker Score: 56
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.19
    Marker Score: 251
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.19
    Marker Score: 115
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.19
    Marker Score: 305
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.18
    Marker Score: 11234
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.18
    Marker Score: 1563
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.18
    Marker Score: 943
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.18
    Marker Score: 107
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.18
    Marker Score: 74
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.18
    Marker Score: 112
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.17
    Marker Score: 46
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.17
    Marker Score: 185
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.17
    Marker Score: 79
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.17
    Marker Score: 302
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.17
    Marker Score: 1628
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.17
    Marker Score: 40
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.17
    Marker Score: 86
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.16
    Marker Score: 60
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.16
    Marker Score: 150
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.16
    Marker Score: 385
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.15
    Marker Score: 76
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.15
    Marker Score: 148
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.15
    Marker Score: 248
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.15
    Marker Score: 42
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.14
    Marker Score: 267
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.14
    Marker Score: 141
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.14
    Marker Score: 58
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.14
    Marker Score: 1199
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.13
    Marker Score: 64
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.13
    Marker Score: 33
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.13
    Marker Score: 40

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Other Information

**Key Characteristics:** 1. **Isoform specificity**: TNNC2 is a fast skeletal isoform, distinct from its slow skeletal and cardiac isoforms, which have different regulatory properties. 2. **Calcium ion binding**: TNNC2 is known for its high affinity for calcium ions, which is essential for muscle contraction regulation. 3. **Protein interactions**: TNNC2 interacts with tropomyosin, actin, and troponin T to form the troponin complex, regulating muscle contraction. 4. **Expression in various tissues**: TNNC2 is highly expressed in skeletal muscle, enterocytes, kidney proximal convoluted tubule epithelial cells, and other tissues, indicating its wide-ranging roles. **Pathways and Functions:** 1. **Muscle contraction regulation**: TNNC2 plays a crucial role in regulating muscle contraction by binding to calcium ions and interacting with tropomyosin and actin. 2. **Actin binding**: TNNC2 binds to actin, which is essential for muscle contraction and relaxation. 3. **Calcium ion binding**: TNNC2 has a high affinity for calcium ions, which is necessary for muscle contraction regulation. 4. **Regulation of muscle contraction**: TNNC2, along with tropomyosin and troponin T, regulates muscle contraction by controlling the interaction between actin and myosin. **Clinical Significance:** 1. **Muscle disorders**: Mutations in the TNNC2 gene have been associated with muscle disorders, such as hypertrophic cardiomyopathy and skeletal muscle disorders. 2. **Muscle fatigue**: Abnormalities in TNNC2 expression and function may contribute to muscle fatigue and weakness in various conditions. 3. **Neurological disorders**: TNNC2 has been implicated in neurological disorders, such as epilepsy and autism, where disruptions in calcium ion homeostasis and muscle contraction regulation may play a role. 4. **Cancer**: TNNC2 expression has been observed in various types of cancer, including colon cancer, suggesting its potential role in cancer progression and metastasis. In conclusion, TNNC2 is a critical component of the troponin complex, regulating muscle contraction in skeletal muscle. Its unique characteristics, pathways, and functions highlight its importance in maintaining muscle homeostasis and overall health. Further research is necessary to fully elucidate the role of TNNC2 in various diseases and to explore its potential as a therapeutic target.

Genular Protein ID: 3484108681

Symbol: TNNC2_HUMAN

Name: Troponin C, skeletal muscle

UniProtKB Accession Codes:

P02585 Q6FH92

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 19 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 10 Ensembl 1 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3166492

Title: Differential expression of slow and fast skeletal muscle troponin C. Slow skeletal muscle troponin C is expressed in human fibroblasts.

PubMed ID: 3166492

DOI: 10.1016/0022-2836(88)90145-3

PubMed ID: 2373703

Title: Cloning, structural analysis, and expression of the human fast twitch skeletal muscle troponin C gene.

PubMed ID: 2373703

DOI: 10.1016/s0021-9258(19)38376-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 978749

Title: Human skeletal muscle proteins. The primary structure of troponin C.

PubMed ID: 978749

DOI: 10.1007/bf01730999

PubMed ID: 33755597

Title: Pathogenic variants in TNNC2 cause congenital myopathy due to an impaired force response to calcium.

PubMed ID: 33755597

DOI: 10.1172/jci145700

Sequence Information:

  • Length: 160
  • Mass: 18122
  • Checksum: EA93729732A0F916
  • Sequence:
    • MTDQQAEARS YLSEEMIAEF KAAFDMFDAD GGGDISVKEL GTVMRMLGQT PTKEELDAII 
EEVDEDGSGT IDFEEFLVMM VRQMKEDAKG KSEEELAECF RIFDRNADGY IDPEELAEIF 
RASGEHVTDE EIESLMKDGD KNNDGRIDFD EFLKMMEGVQ

Genular Protein ID: 3795363840

Symbol: C9J7T9_HUMAN

Name: N/A

UniProtKB Accession Codes:

C9J7T9

Database IDs:

ARBA 3 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 Ensembl 2 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 3 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 145
  • Mass: 16382
  • Checksum: AAD72C6EBC4CFFF2
  • Sequence:
    • MIAEFKAAFD MFDADGGGDI SVKELGTVMR MLGQTPTKEE LDAIIEEVDE DGSGTIDFEE 
FLVMMVRQMK EDAKGKSEEE LAECFRIFDR NADGYIDPEE LAEIFRASGE HVTDEEIESL 
MKDGDKNNDG RIDFDEFLKM MEGVQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.