Details for: TNNT1

Gene ID: 7138

Symbol: TNNT1

Ensembl ID: ENSG00000105048

Description: troponin T1, slow skeletal type

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 61.5255
    Cell Significance Index: -9.5700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 36.0743
    Cell Significance Index: -9.1500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 22.9502
    Cell Significance Index: 559.9700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 21.2427
    Cell Significance Index: -8.6300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.7456
    Cell Significance Index: -9.5500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 6.8962
    Cell Significance Index: 143.0600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 5.3128
    Cell Significance Index: 77.1400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.8845
    Cell Significance Index: 42.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 3.6282
    Cell Significance Index: 116.2100
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 3.5365
    Cell Significance Index: 30.5900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 3.3434
    Cell Significance Index: 48.7300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.4252
    Cell Significance Index: 62.3400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 1.6077
    Cell Significance Index: 25.9400
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.5853
    Cell Significance Index: 11.9700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3730
    Cell Significance Index: 105.3700
  • Cell Name: secondary lymphoid organ macrophage (CL0000867)
    Fold Change: 1.3691
    Cell Significance Index: 10.0500
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.3519
    Cell Significance Index: 6.5800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.2405
    Cell Significance Index: -2.7200
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.2242
    Cell Significance Index: 2.7600
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.9663
    Cell Significance Index: 4.1300
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.6355
    Cell Significance Index: 1.8900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.4678
    Cell Significance Index: 4.0200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3872
    Cell Significance Index: 38.3000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3708
    Cell Significance Index: 334.8200
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.3553
    Cell Significance Index: 4.9300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2739
    Cell Significance Index: 29.7900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2702
    Cell Significance Index: 5.7600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2482
    Cell Significance Index: 14.9000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2357
    Cell Significance Index: 38.3400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.1995
    Cell Significance Index: 3.0300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1640
    Cell Significance Index: 31.2100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1050
    Cell Significance Index: 7.2600
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.1003
    Cell Significance Index: 1.5000
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.0972
    Cell Significance Index: 1.0200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0795
    Cell Significance Index: 2.1300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0789
    Cell Significance Index: 43.0800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0576
    Cell Significance Index: 0.8500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0267
    Cell Significance Index: 11.7900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0029
    Cell Significance Index: 0.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0028
    Cell Significance Index: 0.1000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0009
    Cell Significance Index: -0.3200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0009
    Cell Significance Index: -1.6300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0037
    Cell Significance Index: -0.1000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0076
    Cell Significance Index: -0.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0090
    Cell Significance Index: -16.6200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0103
    Cell Significance Index: -2.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0110
    Cell Significance Index: -16.9100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0125
    Cell Significance Index: -9.4500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0126
    Cell Significance Index: -17.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0144
    Cell Significance Index: -9.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0167
    Cell Significance Index: -12.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0171
    Cell Significance Index: -0.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0192
    Cell Significance Index: -10.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0198
    Cell Significance Index: -2.3100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0239
    Cell Significance Index: -0.5000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0251
    Cell Significance Index: -11.4100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0254
    Cell Significance Index: -0.4700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0254
    Cell Significance Index: -1.1500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0264
    Cell Significance Index: -16.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0285
    Cell Significance Index: -5.6600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0305
    Cell Significance Index: -8.7700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0408
    Cell Significance Index: -1.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0409
    Cell Significance Index: -7.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0503
    Cell Significance Index: -5.1400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0506
    Cell Significance Index: -1.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0532
    Cell Significance Index: -11.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0576
    Cell Significance Index: -8.3700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0647
    Cell Significance Index: -11.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0652
    Cell Significance Index: -8.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0680
    Cell Significance Index: -9.3400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0700
    Cell Significance Index: -4.2900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0813
    Cell Significance Index: -5.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0843
    Cell Significance Index: -10.9000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0911
    Cell Significance Index: -9.4900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1006
    Cell Significance Index: -11.5300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1266
    Cell Significance Index: -4.4000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1337
    Cell Significance Index: -3.0900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1372
    Cell Significance Index: -9.2300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1446
    Cell Significance Index: -7.5300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1489
    Cell Significance Index: -9.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1504
    Cell Significance Index: -11.2100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1520
    Cell Significance Index: -5.5800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1593
    Cell Significance Index: -4.2600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1689
    Cell Significance Index: -10.9000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1699
    Cell Significance Index: -8.5800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1809
    Cell Significance Index: -9.5000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1840
    Cell Significance Index: -2.3600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1842
    Cell Significance Index: -2.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2023
    Cell Significance Index: -11.3500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2113
    Cell Significance Index: -8.6600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2139
    Cell Significance Index: -11.1100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2144
    Cell Significance Index: -3.0700
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.2237
    Cell Significance Index: -1.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2260
    Cell Significance Index: -10.6200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2303
    Cell Significance Index: -3.8600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2326
    Cell Significance Index: -3.2600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2370
    Cell Significance Index: -6.9800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2478
    Cell Significance Index: -8.6800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2667
    Cell Significance Index: -8.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2668
    Cell Significance Index: -7.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TNNT1 is a member of the troponin family of proteins, which are characterized by their ability to bind to actin and regulate muscle contraction. The slow skeletal isoform of TNNT1 is distinct from the other isoforms, which are found in fast-twitch skeletal muscle and cardiac muscle. TNNT1 is a calcium-binding protein that interacts with tropomyosin and tropomyosin-binding protein to regulate muscle contraction. The slow skeletal isoform of TNNT1 is specifically expressed in slow-twitch skeletal muscle fibers, where it plays a critical role in regulating contraction. **Pathways and Functions** TNNT1 is involved in several key pathways, including: 1. **Muscle contraction**: TNNT1 regulates muscle contraction by interacting with tropomyosin and tropomyosin-binding protein to modulate the interaction between actin and myosin. 2. **Negative regulation of muscle contraction**: TNNT1 helps to regulate muscle contraction by binding to tropomyosin and inhibiting its interaction with actin, thereby reducing muscle contraction. 3. **Sarcomere organization**: TNNT1 plays a critical role in the organization of sarcomeres, the functional units of striated muscle tissue. 4. **Protein binding**: TNNT1 interacts with various proteins, including tropomyosin, tropomyosin-binding protein, and actin, to regulate muscle contraction. 5. **Muscle fiber type switching**: TNNT1 is involved in the transition between fast and slow fiber types, which is critical for muscle function and adaptation to exercise. **Clinical Significance** TNNT1 has been implicated in several human diseases, including: 1. **Muscle disorders**: Mutations in TNNT1 have been associated with various muscle disorders, including muscular dystrophy and myotonia. 2. **Cardiac disease**: TNNT1 has been implicated in cardiac disease, including hypertrophic cardiomyopathy and arrhythmias. 3. **Neurological disorders**: TNNT1 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Cancer**: TNNT1 has been implicated in cancer, including colon cancer and breast cancer. In summary, TNNT1 is a critical component of the troponin complex that plays a vital role in regulating muscle contraction and organization. Its pleiotropic functions and high degree of conservation across species make it an important target for understanding muscle function and disease.

Genular Protein ID: 2050380912

Symbol: TNNT1_HUMAN

Name: Troponin T, slow skeletal muscle

UniProtKB Accession Codes:

P13805 O95472 Q16061 Q5U0E1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 16 Ensembl 4 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 5 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2824479

Title: Alternative splicing generates variants in important functional domains of human slow skeletal troponin T.

PubMed ID: 2824479

DOI: 10.1016/s0021-9258(18)47705-8

PubMed ID: 8135831

Title: A new human slow skeletal troponin T (TnTs) mRNA isoform derived from alternative splicing of a single gene.

PubMed ID: 8135831

DOI: 10.1006/bbrc.1994.1305

PubMed ID: 10191089

Title: Close physical linkage of human troponin genes: organization, sequence, and expression of the locus encoding cardiac troponin I and slow skeletal troponin T.

PubMed ID: 10191089

DOI: 10.1006/geno.1998.5702

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8403232

Title: Isolation and cloning by a polymerase chain reaction of a genomic DNA fragment of the human slow skeletal troponin (TNNT1) gene.

PubMed ID: 8403232

DOI: 10.1002/cbf.290110306

PubMed ID: 10952871

Title: A novel nemaline myopathy in the Amish caused by a mutation in troponin T1.

PubMed ID: 10952871

DOI: 10.1086/303089

PubMed ID: 29178646

Title: Novel autosomal dominant TNNT1 mutation causing nemaline myopathy.

PubMed ID: 29178646

DOI: 10.1002/mgg3.325

PubMed ID: 31970803

Title: Novel Recessive TNNT1 Congenital Core-Rod Myopathy in French Canadians.

PubMed ID: 31970803

DOI: 10.1002/ana.25685

PubMed ID: 32994279

Title: Clinical phenotype and loss of the slow skeletal muscle troponin T in three new patients with recessive TNNT1 nemaline myopathy.

PubMed ID: 32994279

DOI: 10.1136/jmedgenet-2019-106714

PubMed ID: 35510366

Title: Autosomal dominantly inherited myopathy likely caused by the TNNT1 variant p.(Asp65Ala).

PubMed ID: 35510366

DOI: 10.1002/humu.24397

PubMed ID: 35165004

Title: TNNT1 myopathy with novel compound heterozygous mutations.

PubMed ID: 35165004

DOI: 10.1016/j.nmd.2021.12.003

Sequence Information:

  • Length: 278
  • Mass: 32948
  • Checksum: D94DB18BC5804E04
  • Sequence:
    • MSDTEEQEYE EEQPEEEAAE EEEEAPEEPE PVAEPEEERP KPSRPVVPPL IPPKIPEGER 
VDFDDIHRKR MEKDLLELQT LIDVHFEQRK KEEEELVALK ERIERRRSER AEQQRFRTEK 
ERERQAKLAE EKMRKEEEEA KKRAEDDAKK KKVLSNMGAH FGGYLVKAEQ KRGKRQTGRE 
MKVRILSERK KPLDIDYMGE EQLRARSAWL PPSQPSCPAR EKAQELSDWI HQLESEKFDL 
MAKLKQQKYE INVLYNRISH AQKFRKGAGK GRVGGRWK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.