Details for: TNNT1

Gene ID: 7138

Symbol: TNNT1

Ensembl ID: ENSG00000105048

Description: troponin T1, slow skeletal type

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.2
    Marker Score: 706
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.17
    Marker Score: 8418
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169083
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.45
    Marker Score: 359
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.38
    Marker Score: 1730.5
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 849
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.17
    Marker Score: 26255
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4805
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.15
    Marker Score: 330
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.14
    Marker Score: 2830
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.1
    Marker Score: 2999
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.09
    Marker Score: 268
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251795
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 790
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.03
    Marker Score: 922
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71816
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48040
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.96
    Marker Score: 1376
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.94
    Marker Score: 3345
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.94
    Marker Score: 14650
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.93
    Marker Score: 387
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5267
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 369
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2736
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.82
    Marker Score: 279
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.82
    Marker Score: 11066.5
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.81
    Marker Score: 403
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1257
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 705
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.68
    Marker Score: 177
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.68
    Marker Score: 1709
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.68
    Marker Score: 515
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.67
    Marker Score: 432
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.61
    Marker Score: 648
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.59
    Marker Score: 139
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.55
    Marker Score: 205
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.53
    Marker Score: 339
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.47
    Marker Score: 806
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.47
    Marker Score: 156
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.43
    Marker Score: 894
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.41
    Marker Score: 191
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.4
    Marker Score: 256
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.4
    Marker Score: 4616
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.39
    Marker Score: 790
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 0.38
    Marker Score: 122
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.38
    Marker Score: 21227
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.38
    Marker Score: 314
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.37
    Marker Score: 120
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.36
    Marker Score: 475
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.36
    Marker Score: 239
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.35
    Marker Score: 660
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.34
    Marker Score: 359.5
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.34
    Marker Score: 90
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.34
    Marker Score: 441
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.34
    Marker Score: 167
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.33
    Marker Score: 1758
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.33
    Marker Score: 134
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.32
    Marker Score: 1182
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.32
    Marker Score: 229
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.31
    Marker Score: 386
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.3
    Marker Score: 213
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.29
    Marker Score: 314
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.29
    Marker Score: 567
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.28
    Marker Score: 194
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.26
    Marker Score: 421
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.26
    Marker Score: 269
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.26
    Marker Score: 138
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.26
    Marker Score: 113
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.26
    Marker Score: 120
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.26
    Marker Score: 491
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.25
    Marker Score: 152
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.25
    Marker Score: 247
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.24
    Marker Score: 112
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.24
    Marker Score: 508
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.24
    Marker Score: 3138
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.23
    Marker Score: 83
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.23
    Marker Score: 112
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.22
    Marker Score: 1921
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.22
    Marker Score: 218
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.22
    Marker Score: 665
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.21
    Marker Score: 98
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.21
    Marker Score: 891
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.21
    Marker Score: 89
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.21
    Marker Score: 66
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.21
    Marker Score: 125
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.21
    Marker Score: 80
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.2
    Marker Score: 201
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.2
    Marker Score: 491

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Other Information

**Key Characteristics** TNNT1 is a member of the troponin family of proteins, which are characterized by their ability to bind to actin and regulate muscle contraction. The slow skeletal isoform of TNNT1 is distinct from the other isoforms, which are found in fast-twitch skeletal muscle and cardiac muscle. TNNT1 is a calcium-binding protein that interacts with tropomyosin and tropomyosin-binding protein to regulate muscle contraction. The slow skeletal isoform of TNNT1 is specifically expressed in slow-twitch skeletal muscle fibers, where it plays a critical role in regulating contraction. **Pathways and Functions** TNNT1 is involved in several key pathways, including: 1. **Muscle contraction**: TNNT1 regulates muscle contraction by interacting with tropomyosin and tropomyosin-binding protein to modulate the interaction between actin and myosin. 2. **Negative regulation of muscle contraction**: TNNT1 helps to regulate muscle contraction by binding to tropomyosin and inhibiting its interaction with actin, thereby reducing muscle contraction. 3. **Sarcomere organization**: TNNT1 plays a critical role in the organization of sarcomeres, the functional units of striated muscle tissue. 4. **Protein binding**: TNNT1 interacts with various proteins, including tropomyosin, tropomyosin-binding protein, and actin, to regulate muscle contraction. 5. **Muscle fiber type switching**: TNNT1 is involved in the transition between fast and slow fiber types, which is critical for muscle function and adaptation to exercise. **Clinical Significance** TNNT1 has been implicated in several human diseases, including: 1. **Muscle disorders**: Mutations in TNNT1 have been associated with various muscle disorders, including muscular dystrophy and myotonia. 2. **Cardiac disease**: TNNT1 has been implicated in cardiac disease, including hypertrophic cardiomyopathy and arrhythmias. 3. **Neurological disorders**: TNNT1 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Cancer**: TNNT1 has been implicated in cancer, including colon cancer and breast cancer. In summary, TNNT1 is a critical component of the troponin complex that plays a vital role in regulating muscle contraction and organization. Its pleiotropic functions and high degree of conservation across species make it an important target for understanding muscle function and disease.

Genular Protein ID: 2050380912

Symbol: TNNT1_HUMAN

Name: Troponin T, slow skeletal muscle

UniProtKB Accession Codes:

P13805 O95472 Q16061 Q5U0E1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 16 Ensembl 4 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 5 SAM 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2824479

Title: Alternative splicing generates variants in important functional domains of human slow skeletal troponin T.

PubMed ID: 2824479

DOI: 10.1016/s0021-9258(18)47705-8

PubMed ID: 8135831

Title: A new human slow skeletal troponin T (TnTs) mRNA isoform derived from alternative splicing of a single gene.

PubMed ID: 8135831

DOI: 10.1006/bbrc.1994.1305

PubMed ID: 10191089

Title: Close physical linkage of human troponin genes: organization, sequence, and expression of the locus encoding cardiac troponin I and slow skeletal troponin T.

PubMed ID: 10191089

DOI: 10.1006/geno.1998.5702

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8403232

Title: Isolation and cloning by a polymerase chain reaction of a genomic DNA fragment of the human slow skeletal troponin (TNNT1) gene.

PubMed ID: 8403232

DOI: 10.1002/cbf.290110306

PubMed ID: 10952871

Title: A novel nemaline myopathy in the Amish caused by a mutation in troponin T1.

PubMed ID: 10952871

DOI: 10.1086/303089

PubMed ID: 29178646

Title: Novel autosomal dominant TNNT1 mutation causing nemaline myopathy.

PubMed ID: 29178646

DOI: 10.1002/mgg3.325

PubMed ID: 31970803

Title: Novel Recessive TNNT1 Congenital Core-Rod Myopathy in French Canadians.

PubMed ID: 31970803

DOI: 10.1002/ana.25685

PubMed ID: 32994279

Title: Clinical phenotype and loss of the slow skeletal muscle troponin T in three new patients with recessive TNNT1 nemaline myopathy.

PubMed ID: 32994279

DOI: 10.1136/jmedgenet-2019-106714

PubMed ID: 35510366

Title: Autosomal dominantly inherited myopathy likely caused by the TNNT1 variant p.(Asp65Ala).

PubMed ID: 35510366

DOI: 10.1002/humu.24397

PubMed ID: 35165004

Title: TNNT1 myopathy with novel compound heterozygous mutations.

PubMed ID: 35165004

DOI: 10.1016/j.nmd.2021.12.003

Sequence Information:

  • Length: 278
  • Mass: 32948
  • Checksum: D94DB18BC5804E04
  • Sequence:
    • MSDTEEQEYE EEQPEEEAAE EEEEAPEEPE PVAEPEEERP KPSRPVVPPL IPPKIPEGER 
VDFDDIHRKR MEKDLLELQT LIDVHFEQRK KEEEELVALK ERIERRRSER AEQQRFRTEK 
ERERQAKLAE EKMRKEEEEA KKRAEDDAKK KKVLSNMGAH FGGYLVKAEQ KRGKRQTGRE 
MKVRILSERK KPLDIDYMGE EQLRARSAWL PPSQPSCPAR EKAQELSDWI HQLESEKFDL 
MAKLKQQKYE INVLYNRISH AQKFRKGAGK GRVGGRWK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.