Details for: LAMA2

Gene ID: 3908

Symbol: LAMA2

Ensembl ID: ENSG00000196569

Description: laminin subunit alpha 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 83.7071
    Cell Significance Index: -39.5200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 41.4153
    Cell Significance Index: 280.6100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 32.0191
    Cell Significance Index: -30.5700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 22.2622
    Cell Significance Index: 319.6900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 21.6075
    Cell Significance Index: -47.2900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 14.2316
    Cell Significance Index: 277.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 10.8868
    Cell Significance Index: 835.4400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 8.7311
    Cell Significance Index: 186.6300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 6.6634
    Cell Significance Index: 171.2800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 5.4563
    Cell Significance Index: 275.7500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.7652
    Cell Significance Index: 26.0600
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.4023
    Cell Significance Index: 14.6400
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 1.1785
    Cell Significance Index: 14.8400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.1635
    Cell Significance Index: 2190.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0373
    Cell Significance Index: 142.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.0273
    Cell Significance Index: 62.9900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.0120
    Cell Significance Index: 12.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.8721
    Cell Significance Index: 48.9400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8405
    Cell Significance Index: 168.6100
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.7881
    Cell Significance Index: 3.7700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.6721
    Cell Significance Index: 16.4000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4508
    Cell Significance Index: 12.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.4479
    Cell Significance Index: 46.6400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2714
    Cell Significance Index: 7.7800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1735
    Cell Significance Index: 156.6200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.1606
    Cell Significance Index: 2.3100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1457
    Cell Significance Index: 27.7200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0926
    Cell Significance Index: 33.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0442
    Cell Significance Index: 28.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0416
    Cell Significance Index: 56.5300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0066
    Cell Significance Index: 4.1000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0015
    Cell Significance Index: -1.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0091
    Cell Significance Index: -6.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0157
    Cell Significance Index: -24.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0160
    Cell Significance Index: -29.5100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0210
    Cell Significance Index: -3.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0296
    Cell Significance Index: -1.0400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0311
    Cell Significance Index: -17.5500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0383
    Cell Significance Index: -6.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0415
    Cell Significance Index: -18.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0494
    Cell Significance Index: -36.2200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0548
    Cell Significance Index: -41.4700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0634
    Cell Significance Index: -34.6200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0683
    Cell Significance Index: -13.5500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0756
    Cell Significance Index: -1.1700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0763
    Cell Significance Index: -7.5500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0810
    Cell Significance Index: -35.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1166
    Cell Significance Index: -33.5500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1214
    Cell Significance Index: -25.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1312
    Cell Significance Index: -22.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1343
    Cell Significance Index: -21.8500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1766
    Cell Significance Index: -21.7200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2017
    Cell Significance Index: -25.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2081
    Cell Significance Index: -24.2500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2731
    Cell Significance Index: -35.2800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.2843
    Cell Significance Index: -3.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2884
    Cell Significance Index: -19.3900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.2904
    Cell Significance Index: -31.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3021
    Cell Significance Index: -18.5700
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.3093
    Cell Significance Index: -4.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3217
    Cell Significance Index: -14.5800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3376
    Cell Significance Index: -38.5400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3425
    Cell Significance Index: -17.8400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3466
    Cell Significance Index: -40.8800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3566
    Cell Significance Index: -36.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3655
    Cell Significance Index: -41.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4292
    Cell Significance Index: -20.1700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4480
    Cell Significance Index: -10.3500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4617
    Cell Significance Index: -11.5400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4712
    Cell Significance Index: -37.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.4810
    Cell Significance Index: -33.2700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4880
    Cell Significance Index: -34.5100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4986
    Cell Significance Index: -14.3700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5159
    Cell Significance Index: -38.4500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.5792
    Cell Significance Index: -8.3000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6715
    Cell Significance Index: -42.3200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7516
    Cell Significance Index: -39.4600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7725
    Cell Significance Index: -40.1300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.7761
    Cell Significance Index: -13.3000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7851
    Cell Significance Index: -20.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.7934
    Cell Significance Index: -36.9900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7951
    Cell Significance Index: -35.1700
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.7963
    Cell Significance Index: -9.2500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.8221
    Cell Significance Index: -21.9500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.8482
    Cell Significance Index: -14.2000
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.8525
    Cell Significance Index: -10.5500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8762
    Cell Significance Index: -30.7000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.9375
    Cell Significance Index: -35.5000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.9585
    Cell Significance Index: -20.7700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.9858
    Cell Significance Index: -15.6400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.9859
    Cell Significance Index: -23.8800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9982
    Cell Significance Index: -32.6800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.0229
    Cell Significance Index: -9.4200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0424
    Cell Significance Index: -33.2000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.0580
    Cell Significance Index: -38.8400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.0676
    Cell Significance Index: -6.4500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.0835
    Cell Significance Index: -37.6500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.0929
    Cell Significance Index: -26.2100
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -1.1154
    Cell Significance Index: -15.0400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.1765
    Cell Significance Index: -23.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural role:** LAMA2 is a subunit of laminin, a high-molecular-weight protein that forms a network of fibers in the ECM. It interacts with other ECM components, such as laminin beta 2 (LAMB2) and collagen type IV (COL4A3), to create a complex network that provides structural support and facilitates cell adhesion. 2. **Cell adhesion:** LAMA2 binds to integrins, which are transmembrane receptors that facilitate cell adhesion to the ECM. This interaction is essential for cell migration, differentiation, and survival. 3. **Signaling pathways:** LAMA2 interacts with various signaling molecules, including the MET receptor tyrosine kinase, which activates the PI3K/AKT and MAPK/ERK pathways. These pathways regulate cell proliferation, differentiation, and survival. 4. **Expression patterns:** LAMA2 is expressed in multiple cell types, including skeletal muscle, cardiac muscle, skin fibroblasts, and hematopoietic stem cells. **Pathways and Functions:** 1. **Axon guidance:** LAMA2 interacts with the axon guidance protein, L1, to regulate axon growth and guidance. 2. **Basement membrane organization:** LAMA2 plays a critical role in maintaining the integrity and organization of the basement membrane, which separates the epithelial and endothelial cells from the underlying connective tissue. 3. **Cell migration:** LAMA2 facilitates cell migration by interacting with integrins and the MET receptor tyrosine kinase. 4. **Muscle organ development:** LAMA2 is involved in the development and maintenance of skeletal and cardiac muscle tissue. 5. **Neurological development:** LAMA2 is expressed in the nervous system and plays a role in axon guidance, dendritic spine formation, and synaptic transmission. **Clinical Significance:** 1. **Muscular dystrophy:** Mutations in the LAMA2 gene have been associated with muscular dystrophy, a group of genetic disorders characterized by progressive muscle weakness and degeneration. 2. **Cancer:** LAMA2 is overexpressed in various types of cancer, including breast, lung, and colon cancer. Its overexpression is associated with tumor progression, metastasis, and poor prognosis. 3. **Neurological disorders:** LAMA2 has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 4. **Cardiovascular disease:** LAMA2 plays a role in the development and maintenance of cardiac muscle tissue, and its dysregulation has been associated with cardiovascular disease. In conclusion, LAMA2 is a critical component of the ECM that plays a vital role in various biological processes, including cell adhesion, migration, and development. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding the functions and regulation of this gene.

Genular Protein ID: 2205407426

Symbol: LAMA2_HUMAN

Name: Laminin subunit alpha-2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8294519

Title: Human laminin M chain (merosin): complete primary structure, chromosomal assignment, and expression of the M and A chain in human fetal tissues.

PubMed ID: 8294519

DOI: 10.1083/jcb.124.3.381

PubMed ID: 8910357

Title: Structure of the human laminin alpha2-chain gene (LAMA2), which is affected in congenital muscular dystrophy.

PubMed ID: 8910357

DOI: 10.1074/jbc.271.44.27664

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 7535762

Title: Human laminin M chain: epitope analysis of its monoclonal antibodies by immunoscreening of cDNA clones and tissue expression.

PubMed ID: 7535762

DOI: 10.1093/oxfordjournals.jbchem.a124666

PubMed ID: 2185464

Title: Merosin, a tissue-specific basement membrane protein, is a laminin-like protein.

PubMed ID: 2185464

DOI: 10.1073/pnas.87.9.3264

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21953594

Title: Clinical and molecular characterization of limb-girdle muscular dystrophy due to LAMA2 mutations.

PubMed ID: 21953594

DOI: 10.1002/mus.22132

PubMed ID: 24957499

Title: Limb girdle muscular dystrophy due to LAMA2 mutations: diagnostic difficulties due to associated peripheral neuropathy.

PubMed ID: 24957499

DOI: 10.1016/j.nmd.2014.05.008

PubMed ID: 24611677

Title: Genotype/phenotype analysis in Chinese laminin-alpha2 deficient congenital muscular dystrophy patients.

PubMed ID: 24611677

DOI: 10.1111/cge.12366

PubMed ID: 11591858

Title: Congenital muscular dystrophy with primary partial laminin alpha-2 chain deficiency: molecular study.

PubMed ID: 11591858

DOI: 10.1212/wnl.57.7.1319

PubMed ID: 12552556

Title: Clinical and molecular study in congenital muscular dystrophy with partial laminin alpha-2 (LAMA2) deficiency.

PubMed ID: 12552556

DOI: 10.1002/humu.10157

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 27234031

Title: Improved diagnostic yield of neuromuscular disorders applying clinical exome sequencing in patients arising from a consanguineous population.

PubMed ID: 27234031

DOI: 10.1111/cge.12810

Sequence Information:

  • Length: 3122
  • Mass: 343905
  • Checksum: E2C13BD6FC1B7BAC
  • Sequence:
  • MPGAAGVLLL LLLSGGLGGV QAQRPQQQRQ SQAHQQRGLF PAVLNLASNA LITTNATCGE 
    KGPEMYCKLV EHVPGQPVRN PQCRICNQNS SNPNQRHPIT NAIDGKNTWW QSPSIKNGIE 
    YHYVTITLDL QQVFQIAYVI VKAANSPRPG NWILERSLDD VEYKPWQYHA VTDTECLTLY 
    NIYPRTGPPS YAKDDEVICT SFYSKIHPLE NGEIHISLIN GRPSADDPSP ELLEFTSARY 
    IRLRFQRIRT LNADLMMFAH KDPREIDPIV TRRYYYSVKD ISVGGMCICY GHARACPLDP 
    ATNKSRCECE HNTCGDSCDQ CCPGFHQKPW RAGTFLTKTE CEACNCHGKA EECYYDENVA 
    RRNLSLNIRG KYIGGGVCIN CTQNTAGINC ETCTDGFFRP KGVSPNYPRP CQPCHCDPIG 
    SLNEVCVKDE KHARRGLAPG SCHCKTGFGG VSCDRCARGY TGYPDCKACN CSGLGSKNED 
    PCFGPCICKE NVEGGDCSRC KSGFFNLQED NWKGCDECFC SGVSNRCQSS YWTYGKIQDM 
    SGWYLTDLPG RIRVAPQQDD LDSPQQISIS NAEARQALPH SYYWSAPAPY LGNKLPAVGG 
    QLTFTISYDL EEEEEDTERV LQLMIILEGN DLSISTAQDE VYLHPSEEHT NVLLLKEESF 
    TIHGTHFPVR RKEFMTVLAN LKRVLLQITY SFGMDAIFRL SSVNLESAVS YPTDGSIAAA 
    VEVCQCPPGY TGSSCESCWP RHRRVNGTIF GGICEPCQCF GHAESCDDVT GECLNCKDHT 
    GGPYCDKCLP GFYGEPTKGT SEDCQPCACP LNIPSNNFSP TCHLDRSLGL ICDGCPVGYT 
    GPRCERCAEG YFGQPSVPGG SCQPCQCNDN LDFSIPGSCD SLSGSCLICK PGTTGRYCEL 
    CADGYFGDAV DAKNCQPCRC NAGGSFSEVC HSQTGQCECR ANVQGQRCDK CKAGTFGLQS 
    ARGCVPCNCN SFGSKSFDCE ESGQCWCQPG VTGKKCDRCA HGYFNFQEGG CTACECSHLG 
    NNCDPKTGRC ICPPNTIGEK CSKCAPNTWG HSITTGCKAC NCSTVGSLDF QCNVNTGQCN 
    CHPKFSGAKC TECSRGHWNY PRCNLCDCFL PGTDATTCDS ETKKCSCSDQ TGQCTCKVNV 
    EGIHCDRCRP GKFGLDAKNP LGCSSCYCFG TTTQCSEAKG LIRTWVTLKA EQTILPLVDE 
    ALQHTTTKGI VFQHPEIVAH MDLMREDLHL EPFYWKLPEQ FEGKKLMAYG GKLKYAIYFE 
    AREETGFSTY NPQVIIRGGT PTHARIIVRH MAAPLIGQLT RHEIEMTEKE WKYYGDDPRV 
    HRTVTREDFL DILYDIHYIL IKATYGNFMR QSRISEISME VAEQGRGTTM TPPADLIEKC 
    DCPLGYSGLS CEACLPGFYR LRSQPGGRTP GPTLGTCVPC QCNGHSSLCD PETSICQNCQ 
    HHTAGDFCER CALGYYGIVK GLPNDCQQCA CPLISSSNNF SPSCVAEGLD DYRCTACPRG 
    YEGQYCERCA PGYTGSPGNP GGSCQECECD PYGSLPVPCD PVTGFCTCRP GATGRKCDGC 
    KHWHAREGWE CVFCGDECTG LLLGDLARLE QMVMSINLTG PLPAPYKMLY GLENMTQELK 
    HLLSPQRAPE RLIQLAEGNL NTLVTEMNEL LTRATKVTAD GEQTGQDAER TNTRAKSLGE 
    FIKELARDAE AVNEKAIKLN ETLGTRDEAF ERNLEGLQKE IDQMIKELRR KNLETQKEIA 
    EDELVAAEAL LKKVKKLFGE SRGENEEMEK DLREKLADYK NKVDDAWDLL REATDKIREA 
    NRLFAVNQKN MTALEKKKEA VESGKRQIEN TLKEGNDILD EANRLADEIN SIIDYVEDIQ 
    TKLPPMSEEL NDKIDDLSQE IKDRKLAEKV SQAESHAAQL NDSSAVLDGI LDEAKNISFN 
    ATAAFKAYSN IKDYIDEAEK VAKEAKDLAH EATKLATGPR GLLKEDAKGC LQKSFRILNE 
    AKKLANDVKE NEDHLNGLKT RIENADARNG DLLRTLNDTL GKLSAIPNDT AAKLQAVKDK 
    ARQANDTAKD VLAQITELHQ NLDGLKKNYN KLADSVAKTN AVVKDPSKNK IIADADATVK 
    NLEQEADRLI DKLKPIKELE DNLKKNISEI KELINQARKQ ANSIKVSVSS GGDCIRTYKP 
    EIKKGSYNNI VVNVKTAVAD NLLFYLGSAK FIDFLAIEMR KGKVSFLWDV GSGVGRVEYP 
    DLTIDDSYWY RIVASRTGRN GTISVRALDG PKASIVPSTH HSTSPPGYTI LDVDANAMLF 
    VGGLTGKLKK ADAVRVITFT GCMGETYFDN KPIGLWNFRE KEGDCKGCTV SPQVEDSEGT 
    IQFDGEGYAL VSRPIRWYPN ISTVMFKFRT FSSSALLMYL ATRDLRDFMS VELTDGHIKV 
    SYDLGSGMAS VVSNQNHNDG KWKSFTLSRI QKQANISIVD IDTNQEENIA TSSSGNNFGL 
    DLKADDKIYF GGLPTLRNLS MKARPEVNLK KYSGCLKDIE ISRTPYNILS SPDYVGVTKG 
    CSLENVYTVS FPKPGFVELS PVPIDVGTEI NLSFSTKNES GIILLGSGGT PAPPRRKRRQ 
    TGQAYYAILL NRGRLEVHLS TGARTMRKIV IRPEPNLFHD GREHSVHVER TRGIFTVQVD 
    ENRRYMQNLT VEQPIEVKKL FVGGAPPEFQ PSPLRNIPPF EGCIWNLVIN SVPMDFARPV 
    SFKNADIGRC AHQKLREDED GAAPAEIVIQ PEPVPTPAFP TPTPVLTHGP CAAESEPALL 
    IGSKQFGLSR NSHIAIAFDD TKVKNRLTIE LEVRTEAESG LLFYMARINH ADFATVQLRN 
    GLPYFSYDLG SGDTHTMIPT KINDGQWHKI KIMRSKQEGI LYVDGASNRT ISPKKADILD 
    VVGMLYVGGL PINYTTRRIG PVTYSIDGCV RNLHMAEAPA DLEQPTSSFH VGTCFANAQR 
    GTYFDGTGFA KAVGGFKVGL DLLVEFEFRT TTTTGVLLGI SSQKMDGMGI EMIDEKLMFH 
    VDNGAGRFTA VYDAGVPGHL CDGQWHKVTA NKIKHRIELT VDGNQVEAQS PNPASTSADT 
    NDPVFVGGFP DDLKQFGLTT SIPFRGCIRS LKLTKGTGKP LEVNFAKALE LRGVQPVSCP 
    AN

Genular Protein ID: 2672880954

Symbol: Q59H37_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 1853
  • Mass: 204559
  • Checksum: 2E1351220FEB375B
  • Sequence:
  • GFSTYNPQVI IRGGTPTHAR IIVRHMAAPL IGQLTRHEIE MTEKEWKYYG DDPRVHRTVT 
    REDFLDILYD IHYILIKATY GNFMRQSRIS EISMEVAEQG RGTTMTPPAD LIEKCDCPLG 
    YSGLSCEACL PGFYRLRSQP GGRTPGPTLG TCVPCQCNGH SSLCDPETSI CQNCQHHTAG 
    DFCERCALGY YGIVKGLPND CQQCACPLIS SSNNFSPSCV AEGLDDYRCT ACPRGYEGQY 
    CERCAPGYTG SPGNPGGSCQ ECECDPYGSL PVPCDPVTGF CTCRPGATGR KCDGCKHWHA 
    REGWECVFCG DECTGLLLGD LARLEQMVMS INLTGPLPAP YKMLYGLENM TQELKHLLSP 
    QRAPERLIQL AEGNLNTLVT EMNELLTRAT KVTADGEQTG QDAERTNTRA KSLGEFIKEL 
    ARDAEAVNEK AIKLNETLGT RDEAFERNLE GLQKEIDQMI KELRRKNLET QKEIAEDELV 
    AAEALLKKVK KLFGESRGEN EEMEKDLREK LADYKNKVDD AWDLLREATD KIREANRLFA 
    VNQKNMTALE KKKEAVESGK RQIENTLKEG NDILDEANRL ADEINSIIDY VEDIQTKLPP 
    MSEELNDKID DLSQEIKDRK LAEKVSQAES HAAQLNDSSA VLDGILDEAK NISFNATAAF 
    KAYSNIKDYI DEAEKVAKEA KDLAHEATKL ATGPRGLLKE DAKGCLQKSF RILNEAKKLA 
    NDVKENEDHL NGLKTRIENA DARNGDLLRT LNDTLGKLSA IPNDTAAKLQ AVKDKARQAN 
    DTAKDVLAQI TELHQNLDGL KKNYNKLADS VAKTNAVVKD PSKNKIIADA DATVKNLEQE 
    ADRLIDKLKP IKELEDNLKK NISEIKELIN QARKQANSIK VSVSSGGDCI RTYKPEIKKG 
    SYNNIVVNVK TAVADNLLFY LGSAKFIDFL AIEMRKGKVS FLWDVGSGVG RVEYPDLTID 
    DSYWYRIVAS RTGRNGTISV RALDGPKASI VPSTHHSTSP PGYTILDVDA NAMLFVGGLT 
    GKLKKADAVR VITFTGCMGE TYFDNKPIGL WNFREKEGDC KGCTVSPQVE DSEGTIQFDG 
    EGYALVSRPI RWYPNISTVM FKFRTFSSSA LLMYLATRDL RDFMSVELTD GHIKVSYDLG 
    SGMASVVSNQ NHNDGKWKSF TLSRIQKQAN ISIVDIDTNQ EENIATSSSG NNFGLDLKAD 
    DKIYFGGLPT LRNLRPEVNL KKYSGCLKDI EISRTPYNIL SSPDYVGVTK GCSLENVYTV 
    SFPKPGFVEL SPVPIDVGTE INLSFSTKNE SGIILLGSGG TPAPPRRKRR QTGQAYYAIL 
    LNRGRLEVHL STGARTMRKI VIRPEPNLFH DGREHSVHVE RTRGIFTVQV DENRRYMQNL 
    TVEQPIEVKK LFVGGAPPEF QPSPLRNIPP FEGCIWNLVI NSVPMDFARP VSFKNADIGR 
    CAHQKLREDE DGAAPAEIVI QPEPVPTPAF PTPTPVLTHG PCAAESEPAL LIGSKQFGLS 
    RNSHIAIAFD DTKVKNRLTI ELEVRTEAES GLLFYMARIN HADFATVQLR NGLPYFSYDL 
    GSGDTHTMIP TKINDGQWHK IKIMRSKQEG ILYVDGASNR TISPKKADIL DVVGMLYVGG 
    LPINYTTRRI GPVTYSIDGC VRNLHMAEAP ADLEQPTSSF HVGTCFANAQ RGTYFDGTGF 
    AKAVGGFKVG LDLLVEFEFR TTTTTGVLLG ISSQKMDGMG IEMIDEKLMF HVDNGAGRFT 
    AVYDAGVPGH LCDGQWHKVT ANKIKHRIEL TVDGNQVEAQ SPNPASTSAD TNDPVFVGGF 
    PDDLKQFGLT TSIPFRGCIR SLKLTKGTGK PLEVNFAKAL ELRGVQPVSC PAN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.