Gene LAMA2 - ENSG00000196569 | NCBI Gene ID: 3908

Details for: LAMA2

Gene ID: 3908

Symbol: LAMA2

Ensembl ID: ENSG00000196569

Description: laminin subunit alpha 2

Associated with

Developmental biology
(R-HSA-1266738)
Ecm proteoglycans
(R-HSA-3000178)
Egr2 and sox10-mediated initiation of schwann cell myelination
(R-HSA-9619665)
Extracellular matrix organization
(R-HSA-1474244)
Laminin interactions
(R-HSA-3000157)
Met activates ptk2 signaling
(R-HSA-8874081)
Met promotes cell motility
(R-HSA-8875878)
Nervous system development
(R-HSA-9675108)
Non-integrin membrane-ecm interactions
(R-HSA-3000171)
Signaling by met
(R-HSA-6806834)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Axon guidance
(GO:0007411)
Basement membrane
(GO:0005604)
Cell adhesion
(GO:0007155)
Collagen-containing extracellular matrix
(GO:0062023)
Dendritic spine
(GO:0043197)
Extracellular matrix structural constituent
(GO:0005201)
Extracellular region
(GO:0005576)
Maintenance of blood-brain barrier
(GO:0035633)
Muscle organ development
(GO:0007517)
Neuromuscular junction
(GO:0031594)
Positive regulation of cell adhesion
(GO:0045785)
Positive regulation of integrin-mediated signaling pathway
(GO:2001046)
Positive regulation of muscle cell differentiation
(GO:0051149)
Positive regulation of synaptic transmission, cholinergic
(GO:0032224)
Protein complex involved in cell-matrix adhesion
(GO:0098637)
Regulation of basement membrane organization
(GO:0110011)
Regulation of cell migration
(GO:0030334)
Regulation of embryonic development
(GO:0045995)
Sarcolemma
(GO:0042383)
Schwann cell differentiation
(GO:0014037)
Signaling receptor binding
(GO:0005102)
Structural molecule activity
(GO:0005198)
Synaptic cleft
(GO:0043083)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 8.79
Marker Score: 5787
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 6.65
Marker Score: 3699
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 5.42
Marker Score: 121097
Cell Name: cardiac neuron (CL0010022)
Fold Change: 5.37
Marker Score: 6696
Cell Name: skin fibroblast (CL0002620)
Fold Change: 5.09
Marker Score: 1319
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 3.79
Marker Score: 13475
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 3.71
Marker Score: 1953
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 3.61
Marker Score: 4152
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.31
Marker Score: 3532
Cell Name: fat cell (CL0000136)
Fold Change: 3.15
Marker Score: 1760.5
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 2.95
Marker Score: 2247
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 2.84
Marker Score: 11894
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 2.51
Marker Score: 4832
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 2.32
Marker Score: 1148
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 2.29
Marker Score: 723
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 2.09
Marker Score: 27847
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.94
Marker Score: 4856
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.84
Marker Score: 4825
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.82
Marker Score: 3693
Cell Name: keratocyte (CL0002363)
Fold Change: 1.77
Marker Score: 408
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 1.73
Marker Score: 1156
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.6
Marker Score: 395
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.6
Marker Score: 1160
Cell Name: Leydig cell (CL0000178)
Fold Change: 1.6
Marker Score: 1720
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.59
Marker Score: 28300
Cell Name: contractile cell (CL0000183)
Fold Change: 1.59
Marker Score: 863
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.51
Marker Score: 9845
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.49
Marker Score: 896
Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168203
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 1.46
Marker Score: 768
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 1.43
Marker Score: 376
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.37
Marker Score: 21513
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.36
Marker Score: 813
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.36
Marker Score: 863
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 1.3
Marker Score: 1792
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 1.29
Marker Score: 3096
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.28
Marker Score: 748
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.24
Marker Score: 2921
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.22
Marker Score: 13797
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 1.21
Marker Score: 354
Cell Name: meningeal macrophage (CL0000879)
Fold Change: 1.17
Marker Score: 329
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.17
Marker Score: 440
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.16
Marker Score: 483
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Marker Score: 4796
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 1.12
Marker Score: 6751
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.09
Marker Score: 499
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.06
Marker Score: 8133
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 1.06
Marker Score: 603
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.05
Marker Score: 266
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251776
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.04
Marker Score: 702
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.03
Marker Score: 35182
Cell Name: photoreceptor cell (CL0000210)
Fold Change: 1.03
Marker Score: 776
Cell Name: Schwann cell (CL0002573)
Fold Change: 1.01
Marker Score: 351
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71796
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48021
Cell Name: mesangial cell (CL0000650)
Fold Change: 1
Marker Score: 1203
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30406
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 505
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 459
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 372
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5279
Cell Name: lactocyte (CL0002325)
Fold Change: 0.92
Marker Score: 14777
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2736
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.91
Marker Score: 284
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 324
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 0.88
Marker Score: 557
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.87
Marker Score: 335
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5280
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.87
Marker Score: 1333
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.84
Marker Score: 219
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.84
Marker Score: 31816
Cell Name: astrocyte (CL0000127)
Fold Change: 0.82
Marker Score: 708
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.81
Marker Score: 332
Cell Name: CNS interneuron (CL0000402)
Fold Change: 0.81
Marker Score: 390
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.81
Marker Score: 2205
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.81
Marker Score: 771
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.8
Marker Score: 608
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.79
Marker Score: 379
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1259
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.77
Marker Score: 47639
Cell Name: brush cell (CL0002204)
Fold Change: 0.76
Marker Score: 698
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.76
Marker Score: 385
Cell Name: stromal cell (CL0000499)
Fold Change: 0.76
Marker Score: 893
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 394
Cell Name: fibroblast (CL0000057)
Fold Change: 0.74
Marker Score: 714
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.74
Marker Score: 488
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.74
Marker Score: 489
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.73
Marker Score: 325
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.72
Marker Score: 229
Cell Name: neuronal brush cell (CL0000555)
Fold Change: 0.71
Marker Score: 2380
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.7
Marker Score: 339
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.7
Marker Score: 237
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 178
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.68
Marker Score: 6892.5
Cell Name: decidual cell (CL2000002)
Fold Change: 0.68
Marker Score: 2919
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.65
Marker Score: 189
Cell Name: fast muscle cell (CL0000190)
Fold Change: 0.64
Marker Score: 193
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 0.62
Marker Score: 768

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**Key characteristics:** - LAMA2 is a large protein with a molecular weight of approximately 130 kDa. - It is a transmembrane protein that is expressed in a variety of cell types. - It is a key component of the ECM, where it helps to organize and maintain the structural integrity of cell adhesion junctions. - It is involved in cell migration, adhesion, and differentiation. - It is a regulator of cell migration and migration-related processes. **Pathways and functions:** - LAMA2 is involved in cell adhesion by binding to other ECM proteins, such as collagen and fibronectin. - It is involved in cell migration by binding to integrins on the surface of cells and facilitating their interaction with the ECM. - It is involved in cell differentiation by promoting the migration and differentiation of neural stem cells. - It is involved in tissue repair by promoting the migration and differentiation of stem cells to the injured site. **Clinical significance:** - Mutations in the LAMA2 gene have been linked to a number of human diseases, including Marfan syndrome, psoriasis, and atherosclerosis. - LAMA2 is a promising target for therapeutic interventions in these diseases. - LAMA2 inhibitors are being investigated as potential treatments for cancer and other diseases that are characterized by abnormal cell adhesion and migration. **Additional information:** - LAMA2 is a secreted protein that is produced by a variety of cell types. - It is a highly conserved protein that is found in all vertebrates. - It is a member of the laminin family of ECM proteins.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Laminin subunit alpha-2
Q59H37_HUMAN

Genular Protein ID: 2205407426

Symbol: LAMA2_HUMAN

Name: Laminin subunit alpha-2

UniProtKB Accession Codes:

P24043 Q14736 Q5VUM2 Q93022

Database IDs:

Citations:

PubMed ID: 8294519

Title: Human laminin M chain (merosin): complete primary structure, chromosomal assignment, and expression of the M and A chain in human fetal tissues.

PubMed ID: 8294519

DOI: 10.1083/jcb.124.3.381

PubMed ID: 8910357

Title: Structure of the human laminin alpha2-chain gene (LAMA2), which is affected in congenital muscular dystrophy.

PubMed ID: 8910357

DOI: 10.1074/jbc.271.44.27664

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 7535762

Title: Human laminin M chain: epitope analysis of its monoclonal antibodies by immunoscreening of cDNA clones and tissue expression.

PubMed ID: 7535762

DOI: 10.1093/oxfordjournals.jbchem.a124666

PubMed ID: 2185464

Title: Merosin, a tissue-specific basement membrane protein, is a laminin-like protein.

PubMed ID: 2185464

DOI: 10.1073/pnas.87.9.3264

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21953594

Title: Clinical and molecular characterization of limb-girdle muscular dystrophy due to LAMA2 mutations.

PubMed ID: 21953594

DOI: 10.1002/mus.22132

PubMed ID: 24957499

Title: Limb girdle muscular dystrophy due to LAMA2 mutations: diagnostic difficulties due to associated peripheral neuropathy.

PubMed ID: 24957499

DOI: 10.1016/j.nmd.2014.05.008

PubMed ID: 24611677

Title: Genotype/phenotype analysis in Chinese laminin-alpha2 deficient congenital muscular dystrophy patients.

PubMed ID: 24611677

DOI: 10.1111/cge.12366

PubMed ID: 11591858

Title: Congenital muscular dystrophy with primary partial laminin alpha-2 chain deficiency: molecular study.

PubMed ID: 11591858

DOI: 10.1212/wnl.57.7.1319

PubMed ID: 12552556

Title: Clinical and molecular study in congenital muscular dystrophy with partial laminin alpha-2 (LAMA2) deficiency.

PubMed ID: 12552556

DOI: 10.1002/humu.10157

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 27234031

Title: Improved diagnostic yield of neuromuscular disorders applying clinical exome sequencing in patients arising from a consanguineous population.

PubMed ID: 27234031

DOI: 10.1111/cge.12810

Sequence Information:

Length: 3122
Mass: 343905
Checksum: E2C13BD6FC1B7BAC
Sequence:

MPGAAGVLLL LLLSGGLGGV QAQRPQQQRQ SQAHQQRGLF PAVLNLASNA LITTNATCGE 
KGPEMYCKLV EHVPGQPVRN PQCRICNQNS SNPNQRHPIT NAIDGKNTWW QSPSIKNGIE 
YHYVTITLDL QQVFQIAYVI VKAANSPRPG NWILERSLDD VEYKPWQYHA VTDTECLTLY 
NIYPRTGPPS YAKDDEVICT SFYSKIHPLE NGEIHISLIN GRPSADDPSP ELLEFTSARY 
IRLRFQRIRT LNADLMMFAH KDPREIDPIV TRRYYYSVKD ISVGGMCICY GHARACPLDP 
ATNKSRCECE HNTCGDSCDQ CCPGFHQKPW RAGTFLTKTE CEACNCHGKA EECYYDENVA 
RRNLSLNIRG KYIGGGVCIN CTQNTAGINC ETCTDGFFRP KGVSPNYPRP CQPCHCDPIG 
SLNEVCVKDE KHARRGLAPG SCHCKTGFGG VSCDRCARGY TGYPDCKACN CSGLGSKNED 
PCFGPCICKE NVEGGDCSRC KSGFFNLQED NWKGCDECFC SGVSNRCQSS YWTYGKIQDM 
SGWYLTDLPG RIRVAPQQDD LDSPQQISIS NAEARQALPH SYYWSAPAPY LGNKLPAVGG 
QLTFTISYDL EEEEEDTERV LQLMIILEGN DLSISTAQDE VYLHPSEEHT NVLLLKEESF 
TIHGTHFPVR RKEFMTVLAN LKRVLLQITY SFGMDAIFRL SSVNLESAVS YPTDGSIAAA 
VEVCQCPPGY TGSSCESCWP RHRRVNGTIF GGICEPCQCF GHAESCDDVT GECLNCKDHT 
GGPYCDKCLP GFYGEPTKGT SEDCQPCACP LNIPSNNFSP TCHLDRSLGL ICDGCPVGYT 
GPRCERCAEG YFGQPSVPGG SCQPCQCNDN LDFSIPGSCD SLSGSCLICK PGTTGRYCEL 
CADGYFGDAV DAKNCQPCRC NAGGSFSEVC HSQTGQCECR ANVQGQRCDK CKAGTFGLQS 
ARGCVPCNCN SFGSKSFDCE ESGQCWCQPG VTGKKCDRCA HGYFNFQEGG CTACECSHLG 
NNCDPKTGRC ICPPNTIGEK CSKCAPNTWG HSITTGCKAC NCSTVGSLDF QCNVNTGQCN 
CHPKFSGAKC TECSRGHWNY PRCNLCDCFL PGTDATTCDS ETKKCSCSDQ TGQCTCKVNV 
EGIHCDRCRP GKFGLDAKNP LGCSSCYCFG TTTQCSEAKG LIRTWVTLKA EQTILPLVDE 
ALQHTTTKGI VFQHPEIVAH MDLMREDLHL EPFYWKLPEQ FEGKKLMAYG GKLKYAIYFE 
AREETGFSTY NPQVIIRGGT PTHARIIVRH MAAPLIGQLT RHEIEMTEKE WKYYGDDPRV 
HRTVTREDFL DILYDIHYIL IKATYGNFMR QSRISEISME VAEQGRGTTM TPPADLIEKC 
DCPLGYSGLS CEACLPGFYR LRSQPGGRTP GPTLGTCVPC QCNGHSSLCD PETSICQNCQ 
HHTAGDFCER CALGYYGIVK GLPNDCQQCA CPLISSSNNF SPSCVAEGLD DYRCTACPRG 
YEGQYCERCA PGYTGSPGNP GGSCQECECD PYGSLPVPCD PVTGFCTCRP GATGRKCDGC 
KHWHAREGWE CVFCGDECTG LLLGDLARLE QMVMSINLTG PLPAPYKMLY GLENMTQELK 
HLLSPQRAPE RLIQLAEGNL NTLVTEMNEL LTRATKVTAD GEQTGQDAER TNTRAKSLGE 
FIKELARDAE AVNEKAIKLN ETLGTRDEAF ERNLEGLQKE IDQMIKELRR KNLETQKEIA 
EDELVAAEAL LKKVKKLFGE SRGENEEMEK DLREKLADYK NKVDDAWDLL REATDKIREA 
NRLFAVNQKN MTALEKKKEA VESGKRQIEN TLKEGNDILD EANRLADEIN SIIDYVEDIQ 
TKLPPMSEEL NDKIDDLSQE IKDRKLAEKV SQAESHAAQL NDSSAVLDGI LDEAKNISFN 
ATAAFKAYSN IKDYIDEAEK VAKEAKDLAH EATKLATGPR GLLKEDAKGC LQKSFRILNE 
AKKLANDVKE NEDHLNGLKT RIENADARNG DLLRTLNDTL GKLSAIPNDT AAKLQAVKDK 
ARQANDTAKD VLAQITELHQ NLDGLKKNYN KLADSVAKTN AVVKDPSKNK IIADADATVK 
NLEQEADRLI DKLKPIKELE DNLKKNISEI KELINQARKQ ANSIKVSVSS GGDCIRTYKP 
EIKKGSYNNI VVNVKTAVAD NLLFYLGSAK FIDFLAIEMR KGKVSFLWDV GSGVGRVEYP 
DLTIDDSYWY RIVASRTGRN GTISVRALDG PKASIVPSTH HSTSPPGYTI LDVDANAMLF 
VGGLTGKLKK ADAVRVITFT GCMGETYFDN KPIGLWNFRE KEGDCKGCTV SPQVEDSEGT 
IQFDGEGYAL VSRPIRWYPN ISTVMFKFRT FSSSALLMYL ATRDLRDFMS VELTDGHIKV 
SYDLGSGMAS VVSNQNHNDG KWKSFTLSRI QKQANISIVD IDTNQEENIA TSSSGNNFGL 
DLKADDKIYF GGLPTLRNLS MKARPEVNLK KYSGCLKDIE ISRTPYNILS SPDYVGVTKG 
CSLENVYTVS FPKPGFVELS PVPIDVGTEI NLSFSTKNES GIILLGSGGT PAPPRRKRRQ 
TGQAYYAILL NRGRLEVHLS TGARTMRKIV IRPEPNLFHD GREHSVHVER TRGIFTVQVD 
ENRRYMQNLT VEQPIEVKKL FVGGAPPEFQ PSPLRNIPPF EGCIWNLVIN SVPMDFARPV 
SFKNADIGRC AHQKLREDED GAAPAEIVIQ PEPVPTPAFP TPTPVLTHGP CAAESEPALL 
IGSKQFGLSR NSHIAIAFDD TKVKNRLTIE LEVRTEAESG LLFYMARINH ADFATVQLRN 
GLPYFSYDLG SGDTHTMIPT KINDGQWHKI KIMRSKQEGI LYVDGASNRT ISPKKADILD 
VVGMLYVGGL PINYTTRRIG PVTYSIDGCV RNLHMAEAPA DLEQPTSSFH VGTCFANAQR 
GTYFDGTGFA KAVGGFKVGL DLLVEFEFRT TTTTGVLLGI SSQKMDGMGI EMIDEKLMFH 
VDNGAGRFTA VYDAGVPGHL CDGQWHKVTA NKIKHRIELT VDGNQVEAQS PNPASTSADT 
NDPVFVGGFP DDLKQFGLTT SIPFRGCIRS LKLTKGTGKP LEVNFAKALE LRGVQPVSCP 
AN

Genular Protein ID: 2672880954

Symbol: Q59H37_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59H37

Database IDs:

Sequence Information:

Length: 1853
Mass: 204559
Checksum: 2E1351220FEB375B
Sequence:

GFSTYNPQVI IRGGTPTHAR IIVRHMAAPL IGQLTRHEIE MTEKEWKYYG DDPRVHRTVT 
REDFLDILYD IHYILIKATY GNFMRQSRIS EISMEVAEQG RGTTMTPPAD LIEKCDCPLG 
YSGLSCEACL PGFYRLRSQP GGRTPGPTLG TCVPCQCNGH SSLCDPETSI CQNCQHHTAG 
DFCERCALGY YGIVKGLPND CQQCACPLIS SSNNFSPSCV AEGLDDYRCT ACPRGYEGQY 
CERCAPGYTG SPGNPGGSCQ ECECDPYGSL PVPCDPVTGF CTCRPGATGR KCDGCKHWHA 
REGWECVFCG DECTGLLLGD LARLEQMVMS INLTGPLPAP YKMLYGLENM TQELKHLLSP 
QRAPERLIQL AEGNLNTLVT EMNELLTRAT KVTADGEQTG QDAERTNTRA KSLGEFIKEL 
ARDAEAVNEK AIKLNETLGT RDEAFERNLE GLQKEIDQMI KELRRKNLET QKEIAEDELV 
AAEALLKKVK KLFGESRGEN EEMEKDLREK LADYKNKVDD AWDLLREATD KIREANRLFA 
VNQKNMTALE KKKEAVESGK RQIENTLKEG NDILDEANRL ADEINSIIDY VEDIQTKLPP 
MSEELNDKID DLSQEIKDRK LAEKVSQAES HAAQLNDSSA VLDGILDEAK NISFNATAAF 
KAYSNIKDYI DEAEKVAKEA KDLAHEATKL ATGPRGLLKE DAKGCLQKSF RILNEAKKLA 
NDVKENEDHL NGLKTRIENA DARNGDLLRT LNDTLGKLSA IPNDTAAKLQ AVKDKARQAN 
DTAKDVLAQI TELHQNLDGL KKNYNKLADS VAKTNAVVKD PSKNKIIADA DATVKNLEQE 
ADRLIDKLKP IKELEDNLKK NISEIKELIN QARKQANSIK VSVSSGGDCI RTYKPEIKKG 
SYNNIVVNVK TAVADNLLFY LGSAKFIDFL AIEMRKGKVS FLWDVGSGVG RVEYPDLTID 
DSYWYRIVAS RTGRNGTISV RALDGPKASI VPSTHHSTSP PGYTILDVDA NAMLFVGGLT 
GKLKKADAVR VITFTGCMGE TYFDNKPIGL WNFREKEGDC KGCTVSPQVE DSEGTIQFDG 
EGYALVSRPI RWYPNISTVM FKFRTFSSSA LLMYLATRDL RDFMSVELTD GHIKVSYDLG 
SGMASVVSNQ NHNDGKWKSF TLSRIQKQAN ISIVDIDTNQ EENIATSSSG NNFGLDLKAD 
DKIYFGGLPT LRNLRPEVNL KKYSGCLKDI EISRTPYNIL SSPDYVGVTK GCSLENVYTV 
SFPKPGFVEL SPVPIDVGTE INLSFSTKNE SGIILLGSGG TPAPPRRKRR QTGQAYYAIL 
LNRGRLEVHL STGARTMRKI VIRPEPNLFH DGREHSVHVE RTRGIFTVQV DENRRYMQNL 
TVEQPIEVKK LFVGGAPPEF QPSPLRNIPP FEGCIWNLVI NSVPMDFARP VSFKNADIGR 
CAHQKLREDE DGAAPAEIVI QPEPVPTPAF PTPTPVLTHG PCAAESEPAL LIGSKQFGLS 
RNSHIAIAFD DTKVKNRLTI ELEVRTEAES GLLFYMARIN HADFATVQLR NGLPYFSYDL 
GSGDTHTMIP TKINDGQWHK IKIMRSKQEG ILYVDGASNR TISPKKADIL DVVGMLYVGG 
LPINYTTRRI GPVTYSIDGC VRNLHMAEAP ADLEQPTSSF HVGTCFANAQ RGTYFDGTGF 
AKAVGGFKVG LDLLVEFEFR TTTTTGVLLG ISSQKMDGMG IEMIDEKLMF HVDNGAGRFT 
AVYDAGVPGH LCDGQWHKVT ANKIKHRIEL TVDGNQVEAQ SPNPASTSAD TNDPVFVGGF 
PDDLKQFGLT TSIPFRGCIR SLKLTKGTGK PLEVNFAKAL ELRGVQPVSC PAN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: LAMA2

Associated with

Cells (max top 100)

Other Information

Human laminin M chain (merosin): complete primary structure, chromosomal assignment, and expression of the M and A chain in human fetal tissues. PubMed ID: 8294519

Structure of the human laminin alpha2-chain gene (LAMA2), which is affected in congenital muscular dystrophy. PubMed ID: 8910357

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

Human laminin M chain: epitope analysis of its monoclonal antibodies by immunoscreening of cDNA clones and tissue expression. PubMed ID: 7535762

Merosin, a tissue-specific basement membrane protein, is a laminin-like protein. PubMed ID: 2185464

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. PubMed ID: 16335952

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

Clinical and molecular characterization of limb-girdle muscular dystrophy due to LAMA2 mutations. PubMed ID: 21953594

Limb girdle muscular dystrophy due to LAMA2 mutations: diagnostic difficulties due to associated peripheral neuropathy. PubMed ID: 24957499

Genotype/phenotype analysis in Chinese laminin-alpha2 deficient congenital muscular dystrophy patients. PubMed ID: 24611677

Congenital muscular dystrophy with primary partial laminin alpha-2 chain deficiency: molecular study. PubMed ID: 11591858

Clinical and molecular study in congenital muscular dystrophy with partial laminin alpha-2 (LAMA2) deficiency. PubMed ID: 12552556

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974

Improved diagnostic yield of neuromuscular disorders applying clinical exome sequencing in patients arising from a consanguineous population. PubMed ID: 27234031