Details for: LAMA2

Gene ID: 3908

Symbol: LAMA2

Ensembl ID: ENSG00000196569

Description: laminin subunit alpha 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 8.79
    Marker Score: 5,787
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 6.65
    Marker Score: 3,699
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 5.42
    Marker Score: 121,097
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 5.37
    Marker Score: 6,696
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 5.09
    Marker Score: 1,319
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 3.79
    Marker Score: 13,475
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 3.71
    Marker Score: 1,953
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 3.61
    Marker Score: 4,152
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.31
    Marker Score: 3,532
  • Cell Name: fat cell (CL0000136)
    Fold Change: 3.15
    Marker Score: 1,761
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 2.95
    Marker Score: 2,247
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.84
    Marker Score: 11,894
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.51
    Marker Score: 4,832
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.32
    Marker Score: 1,148
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.29
    Marker Score: 723
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 2.09
    Marker Score: 27,847
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.94
    Marker Score: 4,856
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.84
    Marker Score: 4,825
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.82
    Marker Score: 3,693
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.77
    Marker Score: 408
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.73
    Marker Score: 1,156
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.6
    Marker Score: 395
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1,160
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.6
    Marker Score: 1,720
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.59
    Marker Score: 28,300
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.59
    Marker Score: 863
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.51
    Marker Score: 9,845
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.49
    Marker Score: 896
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,203
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.46
    Marker Score: 768
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.43
    Marker Score: 376
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.37
    Marker Score: 21,513
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.36
    Marker Score: 813
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 863
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.3
    Marker Score: 1,792
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.29
    Marker Score: 3,096
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.28
    Marker Score: 748
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.24
    Marker Score: 2,921
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.22
    Marker Score: 13,797
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.21
    Marker Score: 354
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 1.17
    Marker Score: 329
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.17
    Marker Score: 440
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 483
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4,796
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.12
    Marker Score: 6,751
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 499
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.06
    Marker Score: 8,133
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.06
    Marker Score: 603
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.05
    Marker Score: 266
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,776
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.04
    Marker Score: 702
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.03
    Marker Score: 35,182
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.03
    Marker Score: 776
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.01
    Marker Score: 351
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,796
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,021
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1
    Marker Score: 1,203
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,279
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.92
    Marker Score: 14,777
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,736
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.91
    Marker Score: 284
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.88
    Marker Score: 557
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.87
    Marker Score: 335
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,280
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.87
    Marker Score: 1,333
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.84
    Marker Score: 219
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.84
    Marker Score: 31,816
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.82
    Marker Score: 708
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.81
    Marker Score: 332
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.81
    Marker Score: 390
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.81
    Marker Score: 2,205
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.81
    Marker Score: 771
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 608
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.79
    Marker Score: 379
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,259
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.77
    Marker Score: 47,639
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 698
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.76
    Marker Score: 385
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.76
    Marker Score: 893
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.74
    Marker Score: 714
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.74
    Marker Score: 488
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.74
    Marker Score: 489
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.73
    Marker Score: 325
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.72
    Marker Score: 229
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.71
    Marker Score: 2,380
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.7
    Marker Score: 339
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.7
    Marker Score: 237
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.68
    Marker Score: 6,893
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.68
    Marker Score: 2,919
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.65
    Marker Score: 189
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.64
    Marker Score: 193
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.62
    Marker Score: 768

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural role:** LAMA2 is a subunit of laminin, a high-molecular-weight protein that forms a network of fibers in the ECM. It interacts with other ECM components, such as laminin beta 2 (LAMB2) and collagen type IV (COL4A3), to create a complex network that provides structural support and facilitates cell adhesion. 2. **Cell adhesion:** LAMA2 binds to integrins, which are transmembrane receptors that facilitate cell adhesion to the ECM. This interaction is essential for cell migration, differentiation, and survival. 3. **Signaling pathways:** LAMA2 interacts with various signaling molecules, including the MET receptor tyrosine kinase, which activates the PI3K/AKT and MAPK/ERK pathways. These pathways regulate cell proliferation, differentiation, and survival. 4. **Expression patterns:** LAMA2 is expressed in multiple cell types, including skeletal muscle, cardiac muscle, skin fibroblasts, and hematopoietic stem cells. **Pathways and Functions:** 1. **Axon guidance:** LAMA2 interacts with the axon guidance protein, L1, to regulate axon growth and guidance. 2. **Basement membrane organization:** LAMA2 plays a critical role in maintaining the integrity and organization of the basement membrane, which separates the epithelial and endothelial cells from the underlying connective tissue. 3. **Cell migration:** LAMA2 facilitates cell migration by interacting with integrins and the MET receptor tyrosine kinase. 4. **Muscle organ development:** LAMA2 is involved in the development and maintenance of skeletal and cardiac muscle tissue. 5. **Neurological development:** LAMA2 is expressed in the nervous system and plays a role in axon guidance, dendritic spine formation, and synaptic transmission. **Clinical Significance:** 1. **Muscular dystrophy:** Mutations in the LAMA2 gene have been associated with muscular dystrophy, a group of genetic disorders characterized by progressive muscle weakness and degeneration. 2. **Cancer:** LAMA2 is overexpressed in various types of cancer, including breast, lung, and colon cancer. Its overexpression is associated with tumor progression, metastasis, and poor prognosis. 3. **Neurological disorders:** LAMA2 has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 4. **Cardiovascular disease:** LAMA2 plays a role in the development and maintenance of cardiac muscle tissue, and its dysregulation has been associated with cardiovascular disease. In conclusion, LAMA2 is a critical component of the ECM that plays a vital role in various biological processes, including cell adhesion, migration, and development. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding the functions and regulation of this gene.

Genular Protein ID: 2205407426

Symbol: LAMA2_HUMAN

Name: Laminin subunit alpha-2

UniProtKB Accession Codes:

P24043 Q14736 Q5VUM2 Q93022

Database IDs:

ABCD 1 AGR 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 ChEMBL 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 100 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 22 Gene3D 4 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 7 PROSITE-ProRule 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 7 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 2 SAM 1 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8294519

Title: Human laminin M chain (merosin): complete primary structure, chromosomal assignment, and expression of the M and A chain in human fetal tissues.

PubMed ID: 8294519

DOI: 10.1083/jcb.124.3.381

PubMed ID: 8910357

Title: Structure of the human laminin alpha2-chain gene (LAMA2), which is affected in congenital muscular dystrophy.

PubMed ID: 8910357

DOI: 10.1074/jbc.271.44.27664

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 7535762

Title: Human laminin M chain: epitope analysis of its monoclonal antibodies by immunoscreening of cDNA clones and tissue expression.

PubMed ID: 7535762

DOI: 10.1093/oxfordjournals.jbchem.a124666

PubMed ID: 2185464

Title: Merosin, a tissue-specific basement membrane protein, is a laminin-like protein.

PubMed ID: 2185464

DOI: 10.1073/pnas.87.9.3264

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21953594

Title: Clinical and molecular characterization of limb-girdle muscular dystrophy due to LAMA2 mutations.

PubMed ID: 21953594

DOI: 10.1002/mus.22132

PubMed ID: 24957499

Title: Limb girdle muscular dystrophy due to LAMA2 mutations: diagnostic difficulties due to associated peripheral neuropathy.

PubMed ID: 24957499

DOI: 10.1016/j.nmd.2014.05.008

PubMed ID: 24611677

Title: Genotype/phenotype analysis in Chinese laminin-alpha2 deficient congenital muscular dystrophy patients.

PubMed ID: 24611677

DOI: 10.1111/cge.12366

PubMed ID: 11591858

Title: Congenital muscular dystrophy with primary partial laminin alpha-2 chain deficiency: molecular study.

PubMed ID: 11591858

DOI: 10.1212/wnl.57.7.1319

PubMed ID: 12552556

Title: Clinical and molecular study in congenital muscular dystrophy with partial laminin alpha-2 (LAMA2) deficiency.

PubMed ID: 12552556

DOI: 10.1002/humu.10157

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 27234031

Title: Improved diagnostic yield of neuromuscular disorders applying clinical exome sequencing in patients arising from a consanguineous population.

PubMed ID: 27234031

DOI: 10.1111/cge.12810

Sequence Information:

  • Length: 3122
  • Mass: 343905
  • Checksum: E2C13BD6FC1B7BAC
  • Sequence:
    • MPGAAGVLLL LLLSGGLGGV QAQRPQQQRQ SQAHQQRGLF PAVLNLASNA LITTNATCGE 
KGPEMYCKLV EHVPGQPVRN PQCRICNQNS SNPNQRHPIT NAIDGKNTWW QSPSIKNGIE 
YHYVTITLDL QQVFQIAYVI VKAANSPRPG NWILERSLDD VEYKPWQYHA VTDTECLTLY 
NIYPRTGPPS YAKDDEVICT SFYSKIHPLE NGEIHISLIN GRPSADDPSP ELLEFTSARY 
IRLRFQRIRT LNADLMMFAH KDPREIDPIV TRRYYYSVKD ISVGGMCICY GHARACPLDP 
ATNKSRCECE HNTCGDSCDQ CCPGFHQKPW RAGTFLTKTE CEACNCHGKA EECYYDENVA 
RRNLSLNIRG KYIGGGVCIN CTQNTAGINC ETCTDGFFRP KGVSPNYPRP CQPCHCDPIG 
SLNEVCVKDE KHARRGLAPG SCHCKTGFGG VSCDRCARGY TGYPDCKACN CSGLGSKNED 
PCFGPCICKE NVEGGDCSRC KSGFFNLQED NWKGCDECFC SGVSNRCQSS YWTYGKIQDM 
SGWYLTDLPG RIRVAPQQDD LDSPQQISIS NAEARQALPH SYYWSAPAPY LGNKLPAVGG 
QLTFTISYDL EEEEEDTERV LQLMIILEGN DLSISTAQDE VYLHPSEEHT NVLLLKEESF 
TIHGTHFPVR RKEFMTVLAN LKRVLLQITY SFGMDAIFRL SSVNLESAVS YPTDGSIAAA 
VEVCQCPPGY TGSSCESCWP RHRRVNGTIF GGICEPCQCF GHAESCDDVT GECLNCKDHT 
GGPYCDKCLP GFYGEPTKGT SEDCQPCACP LNIPSNNFSP TCHLDRSLGL ICDGCPVGYT 
GPRCERCAEG YFGQPSVPGG SCQPCQCNDN LDFSIPGSCD SLSGSCLICK PGTTGRYCEL 
CADGYFGDAV DAKNCQPCRC NAGGSFSEVC HSQTGQCECR ANVQGQRCDK CKAGTFGLQS 
ARGCVPCNCN SFGSKSFDCE ESGQCWCQPG VTGKKCDRCA HGYFNFQEGG CTACECSHLG 
NNCDPKTGRC ICPPNTIGEK CSKCAPNTWG HSITTGCKAC NCSTVGSLDF QCNVNTGQCN 
CHPKFSGAKC TECSRGHWNY PRCNLCDCFL PGTDATTCDS ETKKCSCSDQ TGQCTCKVNV 
EGIHCDRCRP GKFGLDAKNP LGCSSCYCFG TTTQCSEAKG LIRTWVTLKA EQTILPLVDE 
ALQHTTTKGI VFQHPEIVAH MDLMREDLHL EPFYWKLPEQ FEGKKLMAYG GKLKYAIYFE 
AREETGFSTY NPQVIIRGGT PTHARIIVRH MAAPLIGQLT RHEIEMTEKE WKYYGDDPRV 
HRTVTREDFL DILYDIHYIL IKATYGNFMR QSRISEISME VAEQGRGTTM TPPADLIEKC 
DCPLGYSGLS CEACLPGFYR LRSQPGGRTP GPTLGTCVPC QCNGHSSLCD PETSICQNCQ 
HHTAGDFCER CALGYYGIVK GLPNDCQQCA CPLISSSNNF SPSCVAEGLD DYRCTACPRG 
YEGQYCERCA PGYTGSPGNP GGSCQECECD PYGSLPVPCD PVTGFCTCRP GATGRKCDGC 
KHWHAREGWE CVFCGDECTG LLLGDLARLE QMVMSINLTG PLPAPYKMLY GLENMTQELK 
HLLSPQRAPE RLIQLAEGNL NTLVTEMNEL LTRATKVTAD GEQTGQDAER TNTRAKSLGE 
FIKELARDAE AVNEKAIKLN ETLGTRDEAF ERNLEGLQKE IDQMIKELRR KNLETQKEIA 
EDELVAAEAL LKKVKKLFGE SRGENEEMEK DLREKLADYK NKVDDAWDLL REATDKIREA 
NRLFAVNQKN MTALEKKKEA VESGKRQIEN TLKEGNDILD EANRLADEIN SIIDYVEDIQ 
TKLPPMSEEL NDKIDDLSQE IKDRKLAEKV SQAESHAAQL NDSSAVLDGI LDEAKNISFN 
ATAAFKAYSN IKDYIDEAEK VAKEAKDLAH EATKLATGPR GLLKEDAKGC LQKSFRILNE 
AKKLANDVKE NEDHLNGLKT RIENADARNG DLLRTLNDTL GKLSAIPNDT AAKLQAVKDK 
ARQANDTAKD VLAQITELHQ NLDGLKKNYN KLADSVAKTN AVVKDPSKNK IIADADATVK 
NLEQEADRLI DKLKPIKELE DNLKKNISEI KELINQARKQ ANSIKVSVSS GGDCIRTYKP 
EIKKGSYNNI VVNVKTAVAD NLLFYLGSAK FIDFLAIEMR KGKVSFLWDV GSGVGRVEYP 
DLTIDDSYWY RIVASRTGRN GTISVRALDG PKASIVPSTH HSTSPPGYTI LDVDANAMLF 
VGGLTGKLKK ADAVRVITFT GCMGETYFDN KPIGLWNFRE KEGDCKGCTV SPQVEDSEGT 
IQFDGEGYAL VSRPIRWYPN ISTVMFKFRT FSSSALLMYL ATRDLRDFMS VELTDGHIKV 
SYDLGSGMAS VVSNQNHNDG KWKSFTLSRI QKQANISIVD IDTNQEENIA TSSSGNNFGL 
DLKADDKIYF GGLPTLRNLS MKARPEVNLK KYSGCLKDIE ISRTPYNILS SPDYVGVTKG 
CSLENVYTVS FPKPGFVELS PVPIDVGTEI NLSFSTKNES GIILLGSGGT PAPPRRKRRQ 
TGQAYYAILL NRGRLEVHLS TGARTMRKIV IRPEPNLFHD GREHSVHVER TRGIFTVQVD 
ENRRYMQNLT VEQPIEVKKL FVGGAPPEFQ PSPLRNIPPF EGCIWNLVIN SVPMDFARPV 
SFKNADIGRC AHQKLREDED GAAPAEIVIQ PEPVPTPAFP TPTPVLTHGP CAAESEPALL 
IGSKQFGLSR NSHIAIAFDD TKVKNRLTIE LEVRTEAESG LLFYMARINH ADFATVQLRN 
GLPYFSYDLG SGDTHTMIPT KINDGQWHKI KIMRSKQEGI LYVDGASNRT ISPKKADILD 
VVGMLYVGGL PINYTTRRIG PVTYSIDGCV RNLHMAEAPA DLEQPTSSFH VGTCFANAQR 
GTYFDGTGFA KAVGGFKVGL DLLVEFEFRT TTTTGVLLGI SSQKMDGMGI EMIDEKLMFH 
VDNGAGRFTA VYDAGVPGHL CDGQWHKVTA NKIKHRIELT VDGNQVEAQS PNPASTSADT 
NDPVFVGGFP DDLKQFGLTT SIPFRGCIRS LKLTKGTGKP LEVNFAKALE LRGVQPVSCP 
AN

Genular Protein ID: 2672880954

Symbol: Q59H37_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59H37

Database IDs:

ARBA 5 BioGRID-ORCS 1 CDD 2 DNASU 1 EMBL 2 GO 7 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 7 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 6 PharmGKB 1 RefSeq 2 SAM 2 SMART 3 SUPFAM 3

Sequence Information:

  • Length: 1853
  • Mass: 204559
  • Checksum: 2E1351220FEB375B
  • Sequence:
    • GFSTYNPQVI IRGGTPTHAR IIVRHMAAPL IGQLTRHEIE MTEKEWKYYG DDPRVHRTVT 
REDFLDILYD IHYILIKATY GNFMRQSRIS EISMEVAEQG RGTTMTPPAD LIEKCDCPLG 
YSGLSCEACL PGFYRLRSQP GGRTPGPTLG TCVPCQCNGH SSLCDPETSI CQNCQHHTAG 
DFCERCALGY YGIVKGLPND CQQCACPLIS SSNNFSPSCV AEGLDDYRCT ACPRGYEGQY 
CERCAPGYTG SPGNPGGSCQ ECECDPYGSL PVPCDPVTGF CTCRPGATGR KCDGCKHWHA 
REGWECVFCG DECTGLLLGD LARLEQMVMS INLTGPLPAP YKMLYGLENM TQELKHLLSP 
QRAPERLIQL AEGNLNTLVT EMNELLTRAT KVTADGEQTG QDAERTNTRA KSLGEFIKEL 
ARDAEAVNEK AIKLNETLGT RDEAFERNLE GLQKEIDQMI KELRRKNLET QKEIAEDELV 
AAEALLKKVK KLFGESRGEN EEMEKDLREK LADYKNKVDD AWDLLREATD KIREANRLFA 
VNQKNMTALE KKKEAVESGK RQIENTLKEG NDILDEANRL ADEINSIIDY VEDIQTKLPP 
MSEELNDKID DLSQEIKDRK LAEKVSQAES HAAQLNDSSA VLDGILDEAK NISFNATAAF 
KAYSNIKDYI DEAEKVAKEA KDLAHEATKL ATGPRGLLKE DAKGCLQKSF RILNEAKKLA 
NDVKENEDHL NGLKTRIENA DARNGDLLRT LNDTLGKLSA IPNDTAAKLQ AVKDKARQAN 
DTAKDVLAQI TELHQNLDGL KKNYNKLADS VAKTNAVVKD PSKNKIIADA DATVKNLEQE 
ADRLIDKLKP IKELEDNLKK NISEIKELIN QARKQANSIK VSVSSGGDCI RTYKPEIKKG 
SYNNIVVNVK TAVADNLLFY LGSAKFIDFL AIEMRKGKVS FLWDVGSGVG RVEYPDLTID 
DSYWYRIVAS RTGRNGTISV RALDGPKASI VPSTHHSTSP PGYTILDVDA NAMLFVGGLT 
GKLKKADAVR VITFTGCMGE TYFDNKPIGL WNFREKEGDC KGCTVSPQVE DSEGTIQFDG 
EGYALVSRPI RWYPNISTVM FKFRTFSSSA LLMYLATRDL RDFMSVELTD GHIKVSYDLG 
SGMASVVSNQ NHNDGKWKSF TLSRIQKQAN ISIVDIDTNQ EENIATSSSG NNFGLDLKAD 
DKIYFGGLPT LRNLRPEVNL KKYSGCLKDI EISRTPYNIL SSPDYVGVTK GCSLENVYTV 
SFPKPGFVEL SPVPIDVGTE INLSFSTKNE SGIILLGSGG TPAPPRRKRR QTGQAYYAIL 
LNRGRLEVHL STGARTMRKI VIRPEPNLFH DGREHSVHVE RTRGIFTVQV DENRRYMQNL 
TVEQPIEVKK LFVGGAPPEF QPSPLRNIPP FEGCIWNLVI NSVPMDFARP VSFKNADIGR 
CAHQKLREDE DGAAPAEIVI QPEPVPTPAF PTPTPVLTHG PCAAESEPAL LIGSKQFGLS 
RNSHIAIAFD DTKVKNRLTI ELEVRTEAES GLLFYMARIN HADFATVQLR NGLPYFSYDL 
GSGDTHTMIP TKINDGQWHK IKIMRSKQEG ILYVDGASNR TISPKKADIL DVVGMLYVGG 
LPINYTTRRI GPVTYSIDGC VRNLHMAEAP ADLEQPTSSF HVGTCFANAQ RGTYFDGTGF 
AKAVGGFKVG LDLLVEFEFR TTTTTGVLLG ISSQKMDGMG IEMIDEKLMF HVDNGAGRFT 
AVYDAGVPGH LCDGQWHKVT ANKIKHRIEL TVDGNQVEAQ SPNPASTSAD TNDPVFVGGF 
PDDLKQFGLT TSIPFRGCIR SLKLTKGTGK PLEVNFAKAL ELRGVQPVSC PAN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.