Details for: MYOG

Gene ID: 4656

Symbol: MYOG

Ensembl ID: ENSG00000122180

Description: myogenin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 2.1197
    Cell Significance Index: 51.7200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.6622
    Cell Significance Index: 18.0700
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.8689
    Cell Significance Index: 14.0200
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.2436
    Cell Significance Index: 2.3300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.1997
    Cell Significance Index: 2.7700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1445
    Cell Significance Index: 2.0700
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.1313
    Cell Significance Index: 1.7200
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.0682
    Cell Significance Index: 1.0200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0506
    Cell Significance Index: 1.0600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0417
    Cell Significance Index: 0.6000
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.0408
    Cell Significance Index: 0.4500
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.0369
    Cell Significance Index: 0.2100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0087
    Cell Significance Index: 0.1100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0054
    Cell Significance Index: 0.1400
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.0019
    Cell Significance Index: 0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0007
    Cell Significance Index: -1.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0010
    Cell Significance Index: -1.9200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0012
    Cell Significance Index: -1.8500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0012
    Cell Significance Index: -1.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0018
    Cell Significance Index: -1.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0029
    Cell Significance Index: -1.0400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0032
    Cell Significance Index: -0.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0036
    Cell Significance Index: -0.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0045
    Cell Significance Index: -1.2900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0066
    Cell Significance Index: -1.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0079
    Cell Significance Index: -1.1500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0091
    Cell Significance Index: -1.2500
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.0102
    Cell Significance Index: -0.1000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0103
    Cell Significance Index: -0.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0107
    Cell Significance Index: -1.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0186
    Cell Significance Index: -1.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0203
    Cell Significance Index: -1.2500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0227
    Cell Significance Index: -1.1800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0254
    Cell Significance Index: -0.6800
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0289
    Cell Significance Index: -0.3700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0297
    Cell Significance Index: -0.8800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0314
    Cell Significance Index: -1.0900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0328
    Cell Significance Index: -1.8400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0339
    Cell Significance Index: -1.7800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0343
    Cell Significance Index: -1.5200
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.0355
    Cell Significance Index: -0.3800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0365
    Cell Significance Index: -1.2800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0393
    Cell Significance Index: -1.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0396
    Cell Significance Index: -1.8600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0402
    Cell Significance Index: -1.3200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0408
    Cell Significance Index: -1.3000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0456
    Cell Significance Index: -1.3000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0460
    Cell Significance Index: -1.1500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0491
    Cell Significance Index: -1.0800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0491
    Cell Significance Index: -1.3100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0501
    Cell Significance Index: -1.2500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0502
    Cell Significance Index: -1.3200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0508
    Cell Significance Index: -0.8500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0514
    Cell Significance Index: -1.3100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0534
    Cell Significance Index: -1.2800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0573
    Cell Significance Index: -1.1200
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: -0.0585
    Cell Significance Index: -0.4500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0589
    Cell Significance Index: -0.9900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0592
    Cell Significance Index: -1.2800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0598
    Cell Significance Index: -1.2700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0607
    Cell Significance Index: -1.2100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0616
    Cell Significance Index: -0.9100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0617
    Cell Significance Index: -0.6100
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0625
    Cell Significance Index: -0.7200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0632
    Cell Significance Index: -1.3200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0643
    Cell Significance Index: -1.2900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0668
    Cell Significance Index: -1.3200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0670
    Cell Significance Index: -0.9800
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0672
    Cell Significance Index: -0.6500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0673
    Cell Significance Index: -1.3300
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0691
    Cell Significance Index: -0.6700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0704
    Cell Significance Index: -0.8800
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0705
    Cell Significance Index: -0.6800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0743
    Cell Significance Index: -0.9900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0746
    Cell Significance Index: -0.8500
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0748
    Cell Significance Index: -1.0100
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0748
    Cell Significance Index: -0.8100
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.0751
    Cell Significance Index: -0.4600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0755
    Cell Significance Index: -1.2900
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0755
    Cell Significance Index: -1.0600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0769
    Cell Significance Index: -1.3300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0775
    Cell Significance Index: -1.0300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0777
    Cell Significance Index: -1.3200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0778
    Cell Significance Index: -1.2600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0781
    Cell Significance Index: -0.8800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0796
    Cell Significance Index: -0.8400
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0817
    Cell Significance Index: -1.0500
  • Cell Name: secondary lymphoid organ macrophage (CL0000867)
    Fold Change: -0.0817
    Cell Significance Index: -0.6000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0817
    Cell Significance Index: -1.3100
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.0818
    Cell Significance Index: -0.7700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0823
    Cell Significance Index: -0.7800
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0830
    Cell Significance Index: -1.1400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0835
    Cell Significance Index: -0.9100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0843
    Cell Significance Index: -1.0300
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0861
    Cell Significance Index: -0.9400
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0863
    Cell Significance Index: -0.9600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0872
    Cell Significance Index: -0.9000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0879
    Cell Significance Index: -2.1300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0880
    Cell Significance Index: -1.0400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0882
    Cell Significance Index: -1.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Myogenin is a member of the MyoD family of transcription factors, which are key regulators of muscle development and differentiation. It is a potent activator of muscle-specific gene expression, and its expression is tightly regulated during embryonic development and muscle differentiation. Myogenin is also involved in the regulation of cell cycle progression, apoptosis, and cellular differentiation, highlighting its multifaceted role in muscle biology. **Pathways and Functions:** Myogenin plays a central role in the regulation of muscle development and differentiation through several key pathways: 1. **Muscle cell fate commitment:** Myogenin is required for the differentiation of precursor cells into muscle fibers, ensuring the proper development of skeletal muscle tissue. 2. **Myogenesis:** Myogenin regulates the expression of muscle-specific genes, including those involved in muscle contraction, growth, and differentiation. 3. **Cell cycle regulation:** Myogenin inhibits cell cycle progression, preventing the proliferation of muscle precursor cells and ensuring proper muscle development. 4. **Apoptosis regulation:** Myogenin regulates apoptosis in muscle cells, preventing excessive cell death and maintaining tissue homeostasis. 5. **Transcriptional regulation:** Myogenin acts as a transcriptional activator, regulating the expression of muscle-specific genes and influencing the development of skeletal muscle tissue. **Clinical Significance:** Dysregulation of myogenin has been implicated in various muscular disorders, including: 1. **Muscular dystrophy:** Mutations in the MYOG gene have been associated with Duchenne muscular dystrophy and Becker muscular dystrophy, highlighting the critical role of myogenin in muscle development and differentiation. 2. **Myopathies:** Myogenin dysregulation has been implicated in various myopathies, including limb-girdle muscular dystrophy and desmin-related myopathy. 3. **Muscle wasting:** Myogenin dysregulation has been linked to muscle wasting disorders, such as cancer cachexia and sarcopenia. In conclusion, myogenin is a critical transcription factor involved in the regulation of muscle development, differentiation, and maintenance. Its dysregulation has significant clinical implications, highlighting the importance of myogenin in maintaining proper muscle function and preventing muscular disorders. Further studies on myogenin are necessary to elucidate its role in muscle biology and to develop novel therapeutic strategies for muscular disorders.

Genular Protein ID: 3694161513

Symbol: MYOG_HUMAN

Name: Myogenin

UniProtKB Accession Codes:

P15173 Q53XW6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 38 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2583111

Title: Differential expression of myogenic determination genes in muscle cells: possible autoactivation by the Myf gene products.

PubMed ID: 2583111

DOI: 10.1002/j.1460-2075.1989.tb08535.x

PubMed ID: 1659574

Title: Transcription of the muscle regulatory gene Myf4 is regulated by serum components, peptide growth factors and signaling pathways involving G proteins.

PubMed ID: 1659574

DOI: 10.1083/jcb.115.4.905

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24860983

Title: Muscle lim protein isoform negatively regulates striated muscle actin dynamics and differentiation.

PubMed ID: 24860983

DOI: 10.1111/febs.12859

Sequence Information:

  • Length: 224
  • Mass: 25037
  • Checksum: 91421D69B57551FB
  • Sequence:
    • MELYETSPYF YQEPRFYDGE NYLPVHLQGF EPPGYERTEL TLSPEAPGPL EDKGLGTPEH 
CPGQCLPWAC KVCKRKSVSV DRRRAATLRE KRRLKKVNEA FEALKRSTLL NPNQRLPKVE 
ILRSAIQYIE RLQALLSSLN QEERDLRYRG GGGPQPGVPS ECSSHSASCS PEWGSALEFS 
ANPGDHLLTA DPTDAHNLHS LTSIVDSITV EDVSVAFPDE TMPN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.