Details for: FOLR1

Gene ID: 2348

Symbol: FOLR1

Ensembl ID: ENSG00000110195

Description: folate receptor alpha

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 3.94
    Marker Score: 4745
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.93
    Marker Score: 1542
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.92
    Marker Score: 7362
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.88
    Marker Score: 15162
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.59
    Marker Score: 820
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 2.31
    Marker Score: 634
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.31
    Marker Score: 3716
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.24
    Marker Score: 1006
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.22
    Marker Score: 8742
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.17
    Marker Score: 868
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.17
    Marker Score: 14153
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.1
    Marker Score: 607
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.02
    Marker Score: 5417
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.99
    Marker Score: 930
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.92
    Marker Score: 4384
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.89
    Marker Score: 1510
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.8
    Marker Score: 2551
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.71
    Marker Score: 436
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.71
    Marker Score: 27395
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.67
    Marker Score: 1767.5
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1162
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.59
    Marker Score: 1861
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 1.57
    Marker Score: 573
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.56
    Marker Score: 1388
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.55
    Marker Score: 1541
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.42
    Marker Score: 5032
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.4
    Marker Score: 12123
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 865
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.26
    Marker Score: 1277
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.26
    Marker Score: 2291
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.22
    Marker Score: 958
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.19
    Marker Score: 16037
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.18
    Marker Score: 1963
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.14
    Marker Score: 756.5
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4795
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.09
    Marker Score: 1731
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.09
    Marker Score: 269
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.07
    Marker Score: 447
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.02
    Marker Score: 484
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.01
    Marker Score: 420.5
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.01
    Marker Score: 237
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71787.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48013.5
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.99
    Marker Score: 240
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.94
    Marker Score: 1221
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5339
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.93
    Marker Score: 573.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5278
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.87
    Marker Score: 427
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.85
    Marker Score: 1734
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 635.5
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.82
    Marker Score: 451
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.81
    Marker Score: 1322
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.8
    Marker Score: 536
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.78
    Marker Score: 1205
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 705
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.75
    Marker Score: 344
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.73
    Marker Score: 1650
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 462
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.7
    Marker Score: 1329
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.7
    Marker Score: 201
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.68
    Marker Score: 1213
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.68
    Marker Score: 1287
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.65
    Marker Score: 157895.5
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.64
    Marker Score: 22016
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 466.5
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.56
    Marker Score: 378
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.56
    Marker Score: 296
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.55
    Marker Score: 254
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.55
    Marker Score: 1897
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.55
    Marker Score: 2284
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.54
    Marker Score: 227
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.54
    Marker Score: 556
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.51
    Marker Score: 895
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.5
    Marker Score: 561
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.5
    Marker Score: 645
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.5
    Marker Score: 456.5
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 471
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.49
    Marker Score: 435
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.48
    Marker Score: 95
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.47
    Marker Score: 144
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.47
    Marker Score: 1100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.46
    Marker Score: 7212
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 275
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.45
    Marker Score: 489
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.45
    Marker Score: 479
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.45
    Marker Score: 135
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.44
    Marker Score: 226
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.44
    Marker Score: 2791

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - Folate receptor alpha is a single-pass transmembrane protein with a molecular weight of approximately 120 kDa. - It is expressed in high levels in the liver, kidney, and lung. - Folate receptor alpha is a member of the folate receptor family, which are involved in the transport and metabolism of folate and its derivatives. - Folate receptor alpha is a ligand for folatoxin, a protein that is essential for the synthesis of DNA. **Pathways and functions:** - Folate receptor alpha is involved in several important biological processes, including cardiac neural crest cell migration, cargo concentration in the endoplasmic reticulum (ER), and protein trafficking. - It is also involved in the regulation of heart looping and the development of the cardiovascular system. - Folate receptor alpha is a key regulator of liver function, as it is involved in the production of DNA, which is a necessary precursor for the synthesis of proteins. **Clinical significance:** - Mutations in the FOLR1 gene have been linked to several human diseases, including megaloblastic anemia, which is characterized by a low level of red blood cells. - Folate receptor alpha is a potential therapeutic target for treating megaloblastic anemia. **Additional notes:** - Folate receptor alpha is a highly conserved protein, with similar sequences found in animals and humans. - It is a key regulator of cell growth, differentiation, and migration. - Folate receptor alpha is a promising target for cancer therapy, as it is frequently overexpressed on cancer cells.

Genular Protein ID: 1190848143

Symbol: FOLR1_HUMAN

Name: Folate receptor alpha

UniProtKB Accession Codes:

P15328 Q53EW2 Q6FGT8 Q6LC90 Q9UCT2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 5 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 DrugCentral 1 EMBL 12 EPD 1 Ensembl 5 ExpressionAtlas 1 GO 34 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 5 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2768245

Title: Molecular cloning and characterization of the human folate-binding protein cDNA from placenta and malignant tissue culture (KB) cells.

PubMed ID: 2768245

DOI: 10.1016/s0021-9258(18)63786-x

PubMed ID: 2527252

Title: Complementary DNA for the folate binding protein correctly predicts anchoring to the membrane by glycosyl-phosphatidylinositol.

PubMed ID: 2527252

DOI: 10.1172/jci114220

PubMed ID: 1717147

Title: Folate-binding protein is a marker for ovarian cancer.

PubMed ID: 1717147

PubMed ID: 1840502

Title: Cloning of a tumor-associated antigen: MOv18 and MOv19 antibodies recognize a folate-binding protein.

PubMed ID: 1840502

PubMed ID: 1581364

Title: Genomic organization of the gene and a related pseudogene for a human folate binding protein.

PubMed ID: 1581364

DOI: 10.1016/0167-4781(92)90103-7

PubMed ID: 9063895

Title: The divergent 5' termini of the alpha human folate receptor (hFR) mRNAs originate from two tissue-specific promoters and alternative splicing: characterization of the alpha hFR gene structure.

PubMed ID: 9063895

DOI: 10.1021/bi962070h

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2538429

Title: The complete amino acid sequence of a human folate binding protein from KB cells determined from the cDNA.

PubMed ID: 2538429

DOI: 10.1016/s0021-9258(18)83621-3

PubMed ID: 3476960

Title: Purified membrane and soluble folate binding proteins from cultured KB cells have similar amino acid compositions and molecular weights but differ in fatty acid acylation.

PubMed ID: 3476960

DOI: 10.1073/pnas.84.18.6546

PubMed ID: 8033114

Title: UMSCC38 cells amplified at 11q13 for the folate receptor synthesize a mutant nonfunctional folate receptor.

PubMed ID: 8033114

PubMed ID: 7578066

Title: Preferred sites of glycosylphosphatidylinositol modification in folate receptors and constraints in the primary structure of the hydrophobic portion of the signal.

PubMed ID: 7578066

DOI: 10.1021/bi00044a039

PubMed ID: 8567728

Title: Endocytosis of GPI-linked membrane folate receptor-alpha.

PubMed ID: 8567728

DOI: 10.1083/jcb.132.1.35

PubMed ID: 10787414

Title: Expression and differential polarization of the reduced-folate transporter-1 and the folate receptor alpha in mammalian retinal pigment epithelium.

PubMed ID: 10787414

DOI: 10.1074/jbc.m002328200

PubMed ID: 17566972

Title: Computational approach for identification and characterization of GPI-anchored peptides in proteomics experiments.

PubMed ID: 17566972

DOI: 10.1002/pmic.200700068

PubMed ID: 18780401

Title: Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry.

PubMed ID: 18780401

DOI: 10.1002/pmic.200701057

PubMed ID: 19732866

Title: Folate receptor alpha defect causes cerebral folate transport deficiency: a treatable neurodegenerative disorder associated with disturbed myelin metabolism.

PubMed ID: 19732866

DOI: 10.1016/j.ajhg.2009.08.005

PubMed ID: 19074442

Title: A role for the proton-coupled folate transporter (PCFT-SLC46A1) in folate receptor-mediated endocytosis.

PubMed ID: 19074442

DOI: 10.1074/jbc.m807665200

PubMed ID: 23851396

Title: Structural basis for molecular recognition of folic acid by folate receptors.

PubMed ID: 23851396

DOI: 10.1038/nature12327

PubMed ID: 23934049

Title: Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition.

PubMed ID: 23934049

DOI: 10.1073/pnas.1308827110

Sequence Information:

  • Length: 257
  • Mass: 29819
  • Checksum: D458D8BB047C96A6
  • Sequence:
    • MAQRMTTQLL LLLVWVAVVG EAQTRIAWAR TELLNVCMNA KHHKEKPGPE DKLHEQCRPW 
RKNACCSTNT SQEAHKDVSY LYRFNWNHCG EMAPACKRHF IQDTCLYECS PNLGPWIQQV 
DQSWRKERVL NVPLCKEDCE QWWEDCRTSY TCKSNWHKGW NWTSGFNKCA VGAACQPFHF 
YFPTPTVLCN EIWTHSYKVS NYSRGSGRCI QMWFDPAQGN PNEEVARFYA AAMSGAGPWA 
AWPFLLSLAL MLLWLLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.