Details for: FOLR1

Gene ID: 2348

Symbol: FOLR1

Ensembl ID: ENSG00000110195

Description: folate receptor alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 60.6631
    Cell Significance Index: -24.9900
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 14.8226
    Cell Significance Index: 63.7400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 7.6235
    Cell Significance Index: 176.1300
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 6.8450
    Cell Significance Index: 38.1000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 5.3753
    Cell Significance Index: 250.6200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 4.5911
    Cell Significance Index: 48.7800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 4.2748
    Cell Significance Index: 150.2100
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 4.2500
    Cell Significance Index: 43.8400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.8709
    Cell Significance Index: 91.9500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.5445
    Cell Significance Index: 63.6100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.6788
    Cell Significance Index: 216.9000
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 1.5449
    Cell Significance Index: 32.2200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.8933
    Cell Significance Index: 13.8200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6843
    Cell Significance Index: 130.2400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.6692
    Cell Significance Index: 4.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6204
    Cell Significance Index: 29.1600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.4415
    Cell Significance Index: 3.5300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3846
    Cell Significance Index: 44.8200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3662
    Cell Significance Index: 199.9900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3431
    Cell Significance Index: 9.1600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2733
    Cell Significance Index: 16.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2619
    Cell Significance Index: 198.2700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2476
    Cell Significance Index: 24.5000
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: 0.2284
    Cell Significance Index: 1.5300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2069
    Cell Significance Index: 186.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2038
    Cell Significance Index: 22.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1474
    Cell Significance Index: 108.0700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1341
    Cell Significance Index: 21.8100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0885
    Cell Significance Index: 3.8500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0761
    Cell Significance Index: 1.6200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0722
    Cell Significance Index: 9.2600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.0285
    Cell Significance Index: 0.6900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0150
    Cell Significance Index: 1.0400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0047
    Cell Significance Index: -0.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0078
    Cell Significance Index: -1.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0080
    Cell Significance Index: -15.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0103
    Cell Significance Index: -6.5500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0131
    Cell Significance Index: -24.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0157
    Cell Significance Index: -24.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0180
    Cell Significance Index: -24.5300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0187
    Cell Significance Index: -3.7100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0262
    Cell Significance Index: -2.6800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0277
    Cell Significance Index: -20.5500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0315
    Cell Significance Index: -17.7700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0391
    Cell Significance Index: -24.4300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0421
    Cell Significance Index: -19.1200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0423
    Cell Significance Index: -2.5900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0483
    Cell Significance Index: -2.1900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0507
    Cell Significance Index: -1.4600
  • Cell Name: airway submucosal gland collecting duct epithelial cell (CL4033023)
    Fold Change: -0.0531
    Cell Significance Index: -0.3700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0581
    Cell Significance Index: -2.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0620
    Cell Significance Index: -17.8300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0683
    Cell Significance Index: -1.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0806
    Cell Significance Index: -9.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0811
    Cell Significance Index: -14.6200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0929
    Cell Significance Index: -18.6400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1041
    Cell Significance Index: -14.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1104
    Cell Significance Index: -8.2300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1126
    Cell Significance Index: -13.8500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1161
    Cell Significance Index: -19.8200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1163
    Cell Significance Index: -24.4900
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1269
    Cell Significance Index: -1.0500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1529
    Cell Significance Index: -12.1100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1675
    Cell Significance Index: -17.4400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2208
    Cell Significance Index: -4.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2662
    Cell Significance Index: -17.9000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2774
    Cell Significance Index: -4.1800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.2865
    Cell Significance Index: -1.7800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2907
    Cell Significance Index: -22.3100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3062
    Cell Significance Index: -9.0200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3148
    Cell Significance Index: -16.4000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3149
    Cell Significance Index: -11.5600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3304
    Cell Significance Index: -20.3100
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.4032
    Cell Significance Index: -3.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4079
    Cell Significance Index: -22.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4388
    Cell Significance Index: -23.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4618
    Cell Significance Index: -23.9900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4723
    Cell Significance Index: -20.8900
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.4746
    Cell Significance Index: -4.7000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5000
    Cell Significance Index: -17.3800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5004
    Cell Significance Index: -17.5300
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.5570
    Cell Significance Index: -6.2000
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.5816
    Cell Significance Index: -5.6900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5888
    Cell Significance Index: -22.3000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5977
    Cell Significance Index: -19.5700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5988
    Cell Significance Index: -19.0700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.6258
    Cell Significance Index: -17.0400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6269
    Cell Significance Index: -17.8900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6281
    Cell Significance Index: -16.8300
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.6473
    Cell Significance Index: -8.9500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6553
    Cell Significance Index: -17.5300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.6560
    Cell Significance Index: -6.9200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.6596
    Cell Significance Index: -10.8700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.6613
    Cell Significance Index: -16.4900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6779
    Cell Significance Index: -17.8300
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.7027
    Cell Significance Index: -6.6100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7179
    Cell Significance Index: -20.5800
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: -0.7476
    Cell Significance Index: -4.4800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.7567
    Cell Significance Index: -19.2800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.7649
    Cell Significance Index: -19.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FOLR1 is a type II transmembrane glycoprotein composed of four extracellular domains (ECDs) and a single transmembrane domain. The ECDs are rich in cysteine residues and contain a conserved motif (Cys-X-Cys-X-Cys-X-Cys) that is essential for the receptor's binding to folate. FOLR1 is a receptor-mediated endocytosis, where folate binds to the receptor, triggering the internalization of the receptor-ligand complex. The receptor undergoes a process of shedding and recycling, with the ECD being cleaved and released into the extracellular environment. FOLR1 is also associated with various signaling pathways, including the regulation of canonical Wnt signaling and transforming growth factor beta receptor signaling. The receptor's interaction with folate has been shown to modulate these pathways, influencing cellular processes such as proliferation, differentiation, and survival. **Pathways and Functions** FOLR1's primary function is to facilitate the uptake of folate into cells, which is essential for various cellular processes, including: 1. **Cellular proliferation and differentiation**: Folate is required for the synthesis of thymidylate, a nucleotide necessary for DNA synthesis and repair. 2. **Hematopoiesis**: FOLR1 plays a critical role in the development and maintenance of hematopoietic stem cells. 3. **Neural tube closure**: FOLR1 is involved in the regulation of anterior neural tube closure, a critical process in embryonic development. 4. **Heart formation**: FOLR1 is also involved in the regulation of cardiac neural crest cell migration, which is essential for heart formation. FOLR1's interaction with folate has also been shown to modulate various signaling pathways, including: 1. **Wnt/β-catenin signaling**: FOLR1's interaction with folate has been shown to regulate the activity of this pathway, influencing cellular processes such as proliferation and differentiation. 2. **TGF-β signaling**: FOLR1's interaction with folate has also been shown to regulate the activity of this pathway, influencing cellular processes such as proliferation and differentiation. **Clinical Significance** Dysregulation of FOLR1 has been implicated in various diseases, including: 1. **Cancer**: FOLR1 is overexpressed in certain types of cancer, including colorectal, breast, and ovarian cancer. 2. **Neurodegenerative diseases**: FOLR1 has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's and Parkinson's disease. 3. **Cardiovascular disease**: FOLR1 has been implicated in the regulation of cardiac neural crest cell migration, which is essential for heart formation. Targeting FOLR1 has been explored as a therapeutic strategy for the treatment of various diseases, including cancer and neurodegenerative diseases. However, further research is needed to fully understand the role of FOLR1 in human disease and to develop effective therapeutic strategies.

Genular Protein ID: 1190848143

Symbol: FOLR1_HUMAN

Name: Folate receptor alpha

UniProtKB Accession Codes:

P15328 Q53EW2 Q6FGT8 Q6LC90 Q9UCT2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 5 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 DrugCentral 1 EMBL 12 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 34 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2768245

Title: Molecular cloning and characterization of the human folate-binding protein cDNA from placenta and malignant tissue culture (KB) cells.

PubMed ID: 2768245

DOI: 10.1016/s0021-9258(18)63786-x

PubMed ID: 2527252

Title: Complementary DNA for the folate binding protein correctly predicts anchoring to the membrane by glycosyl-phosphatidylinositol.

PubMed ID: 2527252

DOI: 10.1172/jci114220

PubMed ID: 1717147

Title: Folate-binding protein is a marker for ovarian cancer.

PubMed ID: 1717147

PubMed ID: 1840502

Title: Cloning of a tumor-associated antigen: MOv18 and MOv19 antibodies recognize a folate-binding protein.

PubMed ID: 1840502

PubMed ID: 1581364

Title: Genomic organization of the gene and a related pseudogene for a human folate binding protein.

PubMed ID: 1581364

DOI: 10.1016/0167-4781(92)90103-7

PubMed ID: 9063895

Title: The divergent 5' termini of the alpha human folate receptor (hFR) mRNAs originate from two tissue-specific promoters and alternative splicing: characterization of the alpha hFR gene structure.

PubMed ID: 9063895

DOI: 10.1021/bi962070h

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2538429

Title: The complete amino acid sequence of a human folate binding protein from KB cells determined from the cDNA.

PubMed ID: 2538429

DOI: 10.1016/s0021-9258(18)83621-3

PubMed ID: 3476960

Title: Purified membrane and soluble folate binding proteins from cultured KB cells have similar amino acid compositions and molecular weights but differ in fatty acid acylation.

PubMed ID: 3476960

DOI: 10.1073/pnas.84.18.6546

PubMed ID: 8033114

Title: UMSCC38 cells amplified at 11q13 for the folate receptor synthesize a mutant nonfunctional folate receptor.

PubMed ID: 8033114

PubMed ID: 7578066

Title: Preferred sites of glycosylphosphatidylinositol modification in folate receptors and constraints in the primary structure of the hydrophobic portion of the signal.

PubMed ID: 7578066

DOI: 10.1021/bi00044a039

PubMed ID: 8567728

Title: Endocytosis of GPI-linked membrane folate receptor-alpha.

PubMed ID: 8567728

DOI: 10.1083/jcb.132.1.35

PubMed ID: 10787414

Title: Expression and differential polarization of the reduced-folate transporter-1 and the folate receptor alpha in mammalian retinal pigment epithelium.

PubMed ID: 10787414

DOI: 10.1074/jbc.m002328200

PubMed ID: 17566972

Title: Computational approach for identification and characterization of GPI-anchored peptides in proteomics experiments.

PubMed ID: 17566972

DOI: 10.1002/pmic.200700068

PubMed ID: 18780401

Title: Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry.

PubMed ID: 18780401

DOI: 10.1002/pmic.200701057

PubMed ID: 19732866

Title: Folate receptor alpha defect causes cerebral folate transport deficiency: a treatable neurodegenerative disorder associated with disturbed myelin metabolism.

PubMed ID: 19732866

DOI: 10.1016/j.ajhg.2009.08.005

PubMed ID: 19074442

Title: A role for the proton-coupled folate transporter (PCFT-SLC46A1) in folate receptor-mediated endocytosis.

PubMed ID: 19074442

DOI: 10.1074/jbc.m807665200

PubMed ID: 23851396

Title: Structural basis for molecular recognition of folic acid by folate receptors.

PubMed ID: 23851396

DOI: 10.1038/nature12327

PubMed ID: 23934049

Title: Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition.

PubMed ID: 23934049

DOI: 10.1073/pnas.1308827110

Sequence Information:

  • Length: 257
  • Mass: 29819
  • Checksum: D458D8BB047C96A6
  • Sequence:
    • MAQRMTTQLL LLLVWVAVVG EAQTRIAWAR TELLNVCMNA KHHKEKPGPE DKLHEQCRPW 
RKNACCSTNT SQEAHKDVSY LYRFNWNHCG EMAPACKRHF IQDTCLYECS PNLGPWIQQV 
DQSWRKERVL NVPLCKEDCE QWWEDCRTSY TCKSNWHKGW NWTSGFNKCA VGAACQPFHF 
YFPTPTVLCN EIWTHSYKVS NYSRGSGRCI QMWFDPAQGN PNEEVARFYA AAMSGAGPWA 
AWPFLLSLAL MLLWLLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.