Details for: MMP9

Gene ID: 4318

Symbol: MMP9

Ensembl ID: ENSG00000100985

Description: matrix metallopeptidase 9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 14.9291
    Cell Significance Index: -6.1500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 12.3813
    Cell Significance Index: -5.0300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 5.3103
    Cell Significance Index: -5.0700
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 2.4046
    Cell Significance Index: 41.3100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.4174
    Cell Significance Index: 21.9300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.1344
    Cell Significance Index: 30.3500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.8407
    Cell Significance Index: -1.8400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.3964
    Cell Significance Index: 45.2500
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.2286
    Cell Significance Index: 0.6800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0649
    Cell Significance Index: 40.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0366
    Cell Significance Index: 7.2700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0248
    Cell Significance Index: 17.1800
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.0169
    Cell Significance Index: 0.2000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0154
    Cell Significance Index: 0.3000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0147
    Cell Significance Index: 0.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0026
    Cell Significance Index: -4.9400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0033
    Cell Significance Index: -2.4100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0042
    Cell Significance Index: -7.7800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0043
    Cell Significance Index: -0.5600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0050
    Cell Significance Index: -7.6300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0051
    Cell Significance Index: -2.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0057
    Cell Significance Index: -7.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0061
    Cell Significance Index: -3.4600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0066
    Cell Significance Index: -4.9700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0075
    Cell Significance Index: -4.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0078
    Cell Significance Index: -1.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0096
    Cell Significance Index: -5.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0104
    Cell Significance Index: -2.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0114
    Cell Significance Index: -5.1800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0121
    Cell Significance Index: -4.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0129
    Cell Significance Index: -1.4800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0156
    Cell Significance Index: -0.8100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0158
    Cell Significance Index: -4.5500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0176
    Cell Significance Index: -1.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0204
    Cell Significance Index: -4.0900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0234
    Cell Significance Index: -1.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0247
    Cell Significance Index: -2.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0257
    Cell Significance Index: -4.6400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0329
    Cell Significance Index: -4.7800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0331
    Cell Significance Index: -1.3600
  • Cell Name: precursor cell (CL0011115)
    Fold Change: -0.0356
    Cell Significance Index: -0.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0376
    Cell Significance Index: -5.1600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0394
    Cell Significance Index: -4.8500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0399
    Cell Significance Index: -5.1500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0406
    Cell Significance Index: -4.7900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0464
    Cell Significance Index: -5.4100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0493
    Cell Significance Index: -0.3800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0556
    Cell Significance Index: -0.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0586
    Cell Significance Index: -2.7600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0587
    Cell Significance Index: -0.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0737
    Cell Significance Index: -5.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0775
    Cell Significance Index: -5.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0779
    Cell Significance Index: -2.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0784
    Cell Significance Index: -6.0200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0793
    Cell Significance Index: -4.8600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0820
    Cell Significance Index: -4.2600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0851
    Cell Significance Index: -5.4900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0866
    Cell Significance Index: -5.3200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0870
    Cell Significance Index: -4.5700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0940
    Cell Significance Index: -4.1600
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.1030
    Cell Significance Index: -0.9000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1031
    Cell Significance Index: -2.6500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1040
    Cell Significance Index: -3.9400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1091
    Cell Significance Index: -6.1200
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.1160
    Cell Significance Index: -0.9400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1180
    Cell Significance Index: -5.5000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1205
    Cell Significance Index: -4.2200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1264
    Cell Significance Index: -1.6800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1285
    Cell Significance Index: -1.8800
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.1311
    Cell Significance Index: -0.9900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1409
    Cell Significance Index: -2.0500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1512
    Cell Significance Index: -4.9500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1515
    Cell Significance Index: -4.0600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1523
    Cell Significance Index: -5.5900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1524
    Cell Significance Index: -3.1900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1579
    Cell Significance Index: -5.0300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1634
    Cell Significance Index: -2.7800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1652
    Cell Significance Index: -4.8700
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.1664
    Cell Significance Index: -1.4300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1664
    Cell Significance Index: -4.5300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1699
    Cell Significance Index: -3.1400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1737
    Cell Significance Index: -4.9800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1818
    Cell Significance Index: -5.3400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1833
    Cell Significance Index: -5.2300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1841
    Cell Significance Index: -4.6900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1876
    Cell Significance Index: -4.6800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1879
    Cell Significance Index: -4.9400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1890
    Cell Significance Index: -2.8700
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.1940
    Cell Significance Index: -1.9800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1979
    Cell Significance Index: -8.6000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2010
    Cell Significance Index: -5.0200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2043
    Cell Significance Index: -5.1000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2137
    Cell Significance Index: -3.0600
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: -0.2160
    Cell Significance Index: -1.9600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2186
    Cell Significance Index: -4.6400
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.2212
    Cell Significance Index: -2.0000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2219
    Cell Significance Index: -5.6700
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.2226
    Cell Significance Index: -2.5200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2236
    Cell Significance Index: -4.8300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2238
    Cell Significance Index: -3.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MMP9 is a 92-kDa protein that belongs to the subfamily of matrix metalloproteinases (MMPs) that are characterized by their ability to degrade the ECM. It is produced by various cell types, including osteoclasts, enterocytes, and GABAergic interneurons, and is highly expressed in conditions such as cancer, inflammation, and tissue repair. MMP9 is a secreted enzyme that is typically produced as an inactive proenzyme, which is then activated by proteolytic cleavage. **Pathways and Functions** MMP9's activity is regulated by multiple signaling pathways, including: 1. **Apoptotic process**: MMP9 can regulate apoptosis by degrading pro-apoptotic proteins and promoting cell survival. 2. **Cell migration**: MMP9 can facilitate cell migration by degrading the ECM and creating a permissive environment for cell movement. 3. **Cytokine signaling**: MMP9 can modulate cytokine signaling by degrading cytokine receptors and promoting the release of cytokines. 4. **Extracellular matrix organization**: MMP9 can regulate ECM organization by degrading and remodelling the ECM. MMP9's functions include: 1. **Collagen degradation**: MMP9 can degrade collagen, a major component of the ECM, to facilitate tissue remodeling and repair. 2. **Cellular response to stress**: MMP9 can regulate the cellular response to stress by degrading pro-inflammatory proteins and promoting cell survival. 3. **Developmental biology**: MMP9 can play a role in developmental processes, such as embryonic implantation and tissue patterning. 4. **Immune system regulation**: MMP9 can modulate the immune response by regulating the activity of immune cells, such as macrophages and neutrophils. **Clinical Significance** MMP9's dysregulation has been implicated in various diseases, including: 1. **Cancer**: MMP9 overexpression is associated with cancer progression and metastasis. 2. **Inflammatory diseases**: MMP9 overexpression is associated with inflammatory diseases, such as rheumatoid arthritis and atherosclerosis. 3. **Neurodegenerative diseases**: MMP9 dysregulation has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 4. **Wound healing**: MMP9 dysregulation can impair wound healing by disrupting the ECM and promoting inflammation. In conclusion, MMP9 is a multifunctional enzyme that plays a crucial role in various physiological and pathological processes. Its dysregulation has significant clinical implications, and further research is needed to fully understand its role in human disease.

Genular Protein ID: 3783793382

Symbol: MMP9_HUMAN

Name: Matrix metalloproteinase-9

UniProtKB Accession Codes:

P14780 B2R7V9 Q3LR70 Q8N725 Q9H4Z1 Q9UCJ9 Q9UCL1 Q9UDK2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CTD 1 ChEBI 23 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 17 DrugCentral 1 EC 1 EMBL 20 Ensembl 1 EvolutionaryTrace 1 GO 44 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 14 KEGG 1 MANE-Select 1 MEROPS 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 29 PDBsum 29 PIR 1 PIRSF 1 PRIDE 1 PRINTS 2 PRO 1 PROSITE 6 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 9 RefSeq 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2551898

Title: SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages.

PubMed ID: 2551898

DOI: 10.1016/s0021-9258(18)71480-4

PubMed ID: 1653238

Title: Complete structure of the human gene for 92-kDa type IV collagenase. Divergent regulation of expression for the 92- and 72-kilodalton enzyme genes in HT-1080 cells.

PubMed ID: 1653238

DOI: 10.1016/s0021-9258(18)55326-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8426746

Title: Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells.

PubMed ID: 8426746

PubMed ID: 1464361

Title: Human neutrophil gelatinase: a marker for circulating blood neutrophils. Purification and quantitation by enzyme linked immunosorbent assay.

PubMed ID: 1464361

DOI: 10.1111/j.1600-0609.1992.tb00045.x

PubMed ID: 1653055

Title: The cytokine-protease connection: identification of a 96-kD THP-1 gelatinase and regulation by interleukin-1 and cytokine inducers.

PubMed ID: 1653055

DOI: 10.1016/1043-4666(91)90021-5

PubMed ID: 1371271

Title: Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9.

PubMed ID: 1371271

DOI: 10.1016/s0021-9258(19)50563-4

PubMed ID: 1400481

Title: Matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) from HT 1080 human fibrosarcoma cells. Purification and activation of the precursor and enzymic properties.

PubMed ID: 1400481

DOI: 10.1016/s0021-9258(19)36670-0

PubMed ID: 7669817

Title: Proteolytic and non-proteolytic activation of human neutrophil progelatinase B.

PubMed ID: 7669817

DOI: 10.1016/0167-4838(95)00086-a

PubMed ID: 1645657

Title: Purification and identification of 91-kDa neutrophil gelatinase. Release by the activating peptide interleukin-8.

PubMed ID: 1645657

DOI: 10.1111/j.1432-1033.1991.tb16027.x

PubMed ID: 1932376

Title: Cytokine-mediated regulation of human leukocyte gelatinases and role in arthritis.

PubMed ID: 1932376

PubMed ID: 1480034

Title: Latent collagenase and gelatinase from human neutrophils and their activation.

PubMed ID: 1480034

PubMed ID: 1281792

Title: A 25 kDa alpha 2-microglobulin-related protein is a component of the 125 kDa form of human gelatinase.

PubMed ID: 1281792

DOI: 10.1016/0014-5793(92)81511-j

PubMed ID: 7683678

Title: Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase.

PubMed ID: 7683678

DOI: 10.1016/s0021-9258(18)82217-7

PubMed ID: 10644727

Title: Characterization of the monomeric and dimeric forms of latent and active matrix metalloproteinase-9. Differential rates for activation by stromelysin 1.

PubMed ID: 10644727

DOI: 10.1074/jbc.275.4.2661

PubMed ID: 11179305

Title: Salivary histatin 5 is an inhibitor of both host and bacterial enzymes implicated in periodontal disease.

PubMed ID: 11179305

DOI: 10.1128/iai.69.3.1402-1408.2001

PubMed ID: 12879005

Title: Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases.

PubMed ID: 12879005

DOI: 10.1038/sj.onc.1206542

PubMed ID: 16512877

Title: Extracellular matrix protein 1 inhibits the activity of matrix metalloproteinase 9 through high-affinity protein/protein interactions.

PubMed ID: 16512877

DOI: 10.1111/j.0906-6705.2006.00409.x

PubMed ID: 18455130

Title: A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation.

PubMed ID: 18455130

DOI: 10.1016/j.ajhg.2008.03.013

PubMed ID: 19615667

Title: Mutations in MMP9 and MMP13 determine the mode of inheritance and the clinical spectrum of metaphyseal anadysplasia.

PubMed ID: 19615667

DOI: 10.1016/j.ajhg.2009.06.014

PubMed ID: 19893577

Title: The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice.

PubMed ID: 19893577

DOI: 10.1038/embor.2009.233

PubMed ID: 20800577

Title: Non-acylated Mycobacterium bovis glycoprotein MPB83 binds to TLR1/2 and stimulates production of matrix metalloproteinase 9.

PubMed ID: 20800577

DOI: 10.1016/j.bbrc.2010.08.085

PubMed ID: 20479083

Title: Staphylococcal superantigen-like protein 5 inhibits matrix metalloproteinase 9 from human neutrophils.

PubMed ID: 20479083

DOI: 10.1128/iai.00178-10

PubMed ID: 29328525

Title: Role of sialic acid-containing glycans of matrix metalloproteinase-9 (MMP-9) in the interaction between MMP-9 and staphylococcal superantigen-like protein 5.

PubMed ID: 29328525

DOI: 10.1111/1348-0421.12573

PubMed ID: 32883094

Title: Anti-inflammatory actions of soluble ninjurin-1 ameliorate atherosclerosis.

PubMed ID: 32883094

DOI: 10.1161/circulationaha.120.046907

PubMed ID: 12077439

Title: Structure of the C-terminally truncated human ProMMP9, a gelatin-binding matrix metalloproteinase.

PubMed ID: 12077439

DOI: 10.1107/s0907444902007849

PubMed ID: 12051944

Title: Crystal structure of human MMP9 in complex with a reverse hydroxamate inhibitor.

PubMed ID: 12051944

DOI: 10.1016/s0022-2836(02)00262-0

PubMed ID: 12126625

Title: Structural basis of the adaptive molecular recognition by MMP9.

PubMed ID: 12126625

DOI: 10.1016/s0022-2836(02)00558-2

PubMed ID: 10598806

Title: Genetic variation at the matrix metalloproteinase-9 locus on chromosome 20q12.2-13.1.

PubMed ID: 10598806

DOI: 10.1007/s004390051124

Sequence Information:

  • Length: 707
  • Mass: 78458
  • Checksum: 2165AC8CA1466209
  • Sequence:
    • MSLWQPLVLV LLVLGCCFAA PRQRQSTLVL FPGDLRTNLT DRQLAEEYLY RYGYTRVAEM 
RGESKSLGPA LLLLQKQLSL PETGELDSAT LKAMRTPRCG VPDLGRFQTF EGDLKWHHHN 
ITYWIQNYSE DLPRAVIDDA FARAFALWSA VTPLTFTRVY SRDADIVIQF GVAEHGDGYP 
FDGKDGLLAH AFPPGPGIQG DAHFDDDELW SLGKGVVVPT RFGNADGAAC HFPFIFEGRS 
YSACTTDGRS DGLPWCSTTA NYDTDDRFGF CPSERLYTQD GNADGKPCQF PFIFQGQSYS 
ACTTDGRSDG YRWCATTANY DRDKLFGFCP TRADSTVMGG NSAGELCVFP FTFLGKEYST 
CTSEGRGDGR LWCATTSNFD SDKKWGFCPD QGYSLFLVAA HEFGHALGLD HSSVPEALMY 
PMYRFTEGPP LHKDDVNGIR HLYGPRPEPE PRPPTTTTPQ PTAPPTVCPT GPPTVHPSER 
PTAGPTGPPS AGPTGPPTAG PSTATTVPLS PVDDACNVNI FDAIAEIGNQ LYLFKDGKYW 
RFSEGRGSRP QGPFLIADKW PALPRKLDSV FEERLSKKLF FFSGRQVWVY TGASVLGPRR 
LDKLGLGADV AQVTGALRSG RGKMLLFSGR RLWRFDVKAQ MVDPRSASEV DRMFPGVPLD 
THDVFQYREK AYFCQDRFYW RVSSRSELNQ VDQVGYVTYD ILQCPED

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.