Details for: FGL1

Gene ID: 2267

Symbol: FGL1

Ensembl ID: ENSG00000104760

Description: fibrinogen like 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 241.0140
    Cell Significance Index: 121.0400
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 69.5805
    Cell Significance Index: 183.5500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 16.2265
    Cell Significance Index: 273.3400
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 4.1686
    Cell Significance Index: 15.7000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.5956
    Cell Significance Index: 713.5500
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 3.4662
    Cell Significance Index: 40.9700
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 3.1517
    Cell Significance Index: 18.1500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.3687
    Cell Significance Index: 19.3200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.8239
    Cell Significance Index: 26.9200
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 1.6350
    Cell Significance Index: 4.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.5706
    Cell Significance Index: 268.1900
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.5493
    Cell Significance Index: 15.2900
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.4480
    Cell Significance Index: 5.0400
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 1.3344
    Cell Significance Index: 15.7000
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.0121
    Cell Significance Index: 7.9900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.9124
    Cell Significance Index: 22.1000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.7712
    Cell Significance Index: 11.2400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.6638
    Cell Significance Index: 75.7700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4110
    Cell Significance Index: 11.0000
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.2546
    Cell Significance Index: 3.5600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1061
    Cell Significance Index: 66.2800
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.0899
    Cell Significance Index: 0.8600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0868
    Cell Significance Index: 11.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0835
    Cell Significance Index: 6.2200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.0642
    Cell Significance Index: 1.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0425
    Cell Significance Index: 4.8700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0161
    Cell Significance Index: 12.1600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0115
    Cell Significance Index: 0.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0095
    Cell Significance Index: 7.0400
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.0092
    Cell Significance Index: 0.1000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0073
    Cell Significance Index: 0.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0059
    Cell Significance Index: 3.2300
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.0058
    Cell Significance Index: 0.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0046
    Cell Significance Index: 1.6600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0034
    Cell Significance Index: 2.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0005
    Cell Significance Index: -0.9400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0012
    Cell Significance Index: -0.2500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0016
    Cell Significance Index: -0.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0017
    Cell Significance Index: -3.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0019
    Cell Significance Index: -2.9600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0023
    Cell Significance Index: -1.3000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0025
    Cell Significance Index: -3.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0058
    Cell Significance Index: -1.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0066
    Cell Significance Index: -1.9000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0071
    Cell Significance Index: -0.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0073
    Cell Significance Index: -4.6300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0092
    Cell Significance Index: -4.1600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0109
    Cell Significance Index: -0.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0125
    Cell Significance Index: -1.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0146
    Cell Significance Index: -2.6400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0168
    Cell Significance Index: -0.2400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0193
    Cell Significance Index: -0.7900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0194
    Cell Significance Index: -0.3200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0194
    Cell Significance Index: -0.5200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0238
    Cell Significance Index: -0.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0243
    Cell Significance Index: -2.5400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0250
    Cell Significance Index: -3.6400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0276
    Cell Significance Index: -3.5600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0309
    Cell Significance Index: -0.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0319
    Cell Significance Index: -3.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0320
    Cell Significance Index: -3.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0357
    Cell Significance Index: -2.4000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0375
    Cell Significance Index: -1.8900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0379
    Cell Significance Index: -0.5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0392
    Cell Significance Index: -3.0100
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0393
    Cell Significance Index: -0.3600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0439
    Cell Significance Index: -0.9100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0441
    Cell Significance Index: -1.6700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0461
    Cell Significance Index: -2.0400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0476
    Cell Significance Index: -0.6600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0486
    Cell Significance Index: -4.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0522
    Cell Significance Index: -2.9300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0542
    Cell Significance Index: -3.3300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0674
    Cell Significance Index: -2.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0679
    Cell Significance Index: -3.1900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0737
    Cell Significance Index: -3.8300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0761
    Cell Significance Index: -2.4900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0761
    Cell Significance Index: -3.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0772
    Cell Significance Index: -3.6000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0786
    Cell Significance Index: -0.9000
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0792
    Cell Significance Index: -0.9800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0798
    Cell Significance Index: -2.5400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0810
    Cell Significance Index: -4.2200
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0862
    Cell Significance Index: -0.8000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0869
    Cell Significance Index: -3.1900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0875
    Cell Significance Index: -1.2700
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0917
    Cell Significance Index: -0.9500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0939
    Cell Significance Index: -2.9700
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: -0.0963
    Cell Significance Index: -1.0700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0985
    Cell Significance Index: -3.4600
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0993
    Cell Significance Index: -0.5200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0996
    Cell Significance Index: -2.8700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1002
    Cell Significance Index: -2.5000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1006
    Cell Significance Index: -2.1000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1006
    Cell Significance Index: -2.8700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1020
    Cell Significance Index: -2.6000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1042
    Cell Significance Index: -0.7100
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1068
    Cell Significance Index: -0.9100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1082
    Cell Significance Index: -1.4000
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.1098
    Cell Significance Index: -1.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FGL1 is a member of the fibrinogen-like family of proteins, characterized by its ability to bind to collagen, fibrinogen, and other proteins. The FGL1 protein has a unique structure, comprising two domains, each with a specific binding site. This protein is primarily expressed in the liver, pancreas, and immune cells, suggesting its involvement in tissue-specific functions. **Pathways and Functions:** FGL1 is implicated in several biological pathways, including: 1. **Adaptive Immune Response:** FGL1 is expressed on the surface of immune cells, such as macrophages and granulocytes, and plays a role in modulating T-cell activation. It can bind to CD4+ T cells, influencing their proliferation and differentiation. 2. **Cell-Matrix Adhesion:** FGL1 interacts with collagen, facilitating cell adhesion and migration. This process is crucial for tissue repair, wound healing, and cancer metastasis. 3. **Hepatocyte Proliferation:** FGL1 is overexpressed in the periportal region of hepatocytes, suggesting its involvement in liver regeneration and fibrosis. 4. **Platelet Aggregation:** Although FGL1 does not directly participate in coagulation, it can bind to platelets, influencing their activation and aggregation. **Clinical Significance:** The dysregulation of FGL1 has been implicated in various diseases, including: 1. **Liver Diseases:** FGL1 expression is altered in liver fibrosis, cirrhosis, and hepatocellular carcinoma, suggesting its role in liver regeneration and tumor progression. 2. **Immune-Mediated Disorders:** FGL1 is involved in autoimmune diseases, such as rheumatoid arthritis and lupus, where its dysregulation contributes to immune dysbalance. 3. **Cancer:** FGL1 expression is elevated in various types of cancer, including breast, lung, and colon cancer, where it may promote tumor progression and metastasis. 4. **Cardiovascular Diseases:** FGL1 is also involved in cardiovascular diseases, such as atherosclerosis and hypertension, where its dysregulation contributes to vascular dysfunction. In conclusion, FGL1 is a multifunctional gene with significant implications in immune response, cell adhesion, and tissue repair. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying FGL1's functions and its potential therapeutic applications.

Genular Protein ID: 4183808665

Symbol: FGL1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q08830 A6NKU4 Q4PJH9 Q53YF1 Q8NG32 Q96KW6 Q96QM6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 7 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 5 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8390249

Title: Molecular cloning and initial characterization of a novel fibrinogen-related gene, HFREP-1.

PubMed ID: 8390249

DOI: 10.1006/bbrc.1993.1678

PubMed ID: 11470158

Title: Molecular cloning and functional expression analysis of a cDNA for human hepassocin, a liver-specific protein with hepatocyte mitogenic activity.

PubMed ID: 11470158

DOI: 10.1016/s0167-4781(01)00249-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18039467

Title: Fibrinogen-like protein 1, a hepatocyte derived protein is an acute phase reactant.

PubMed ID: 18039467

DOI: 10.1016/j.bbrc.2007.11.069

PubMed ID: 19880967

Title: Recombinant human hepassocin stimulates proliferation of hepatocytes in vivo and improves survival in rats with fulminant hepatic failure.

PubMed ID: 19880967

DOI: 10.1136/gut.2008.171124

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 30580966

Title: Fibrinogen-like protein 1 is a major immune inhibitory ligand of LAG-3.

PubMed ID: 30580966

DOI: 10.1016/j.cell.2018.11.010

Sequence Information:

  • Length: 312
  • Mass: 36379
  • Checksum: 9297153AEA746C31
  • Sequence:
    • MAKVFSFILV TTALTMGREI SALEDCAQEQ MRLRAQVRLL ETRVKQQQVK IKQLLQENEV 
QFLDKGDENT VIDLGSKRQY ADCSEIFNDG YKLSGFYKIK PLQSPAEFSV YCDMSDGGGW 
TVIQRRSDGS ENFNRGWKDY ENGFGNFVQK HGEYWLGNKN LHFLTTQEDY TLKIDLADFE 
KNSRYAQYKN FKVGDEKNFY ELNIGEYSGT AGDSLAGNFH PEVQWWASHQ RMKFSTWDRD 
HDNYEGNCAE EDQSGWWFNR CHSANLNGVY YSGPYTAKTD NGIVWYTWHG WWYSLKSVVM 
KIRPNDFIPN VI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.