Details for: FGL1

Gene ID: 2267

Symbol: FGL1

Ensembl ID: ENSG00000104760

Description: fibrinogen like 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 5.36
    Marker Score: 3,019
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 3.95
    Marker Score: 12,952
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 3.65
    Marker Score: 19,650
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.3
    Marker Score: 14,801
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 2.3
    Marker Score: 9,925
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.08
    Marker Score: 2,229
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 1.88
    Marker Score: 582
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 870
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.27
    Marker Score: 19,916
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.24
    Marker Score: 617
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.24
    Marker Score: 2,514
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.2
    Marker Score: 1,199
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.18
    Marker Score: 326
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.13
    Marker Score: 770
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.1
    Marker Score: 2,093
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.09
    Marker Score: 238
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.05
    Marker Score: 22,477
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 796
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.03
    Marker Score: 387
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,825
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,049
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,351
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,741
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.91
    Marker Score: 1,930
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.86
    Marker Score: 1,787
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.82
    Marker Score: 800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,262
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.77
    Marker Score: 423
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.68
    Marker Score: 214
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.59
    Marker Score: 280
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.59
    Marker Score: 388
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.55
    Marker Score: 544
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.54
    Marker Score: 327
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.54
    Marker Score: 173
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.53
    Marker Score: 963
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.52
    Marker Score: 229
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.51
    Marker Score: 316
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.5
    Marker Score: 266
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 475
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.48
    Marker Score: 249
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.48
    Marker Score: 315
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.47
    Marker Score: 354
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.43
    Marker Score: 186
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.4
    Marker Score: 223
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.38
    Marker Score: 5,063
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 372
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.37
    Marker Score: 282
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.35
    Marker Score: 566
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.35
    Marker Score: 161
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.34
    Marker Score: 129
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.34
    Marker Score: 120
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.31
    Marker Score: 111
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.27
    Marker Score: 193
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.27
    Marker Score: 121
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.27
    Marker Score: 298
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.26
    Marker Score: 269
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.25
    Marker Score: 149
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.25
    Marker Score: 145
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.24
    Marker Score: 74
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.24
    Marker Score: 593
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.24
    Marker Score: 151
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.24
    Marker Score: 82
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.23
    Marker Score: 140
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.22
    Marker Score: 106
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.22
    Marker Score: 148
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.22
    Marker Score: 88
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.2
    Marker Score: 476
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.2
    Marker Score: 117
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.19
    Marker Score: 173
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.19
    Marker Score: 167
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.19
    Marker Score: 79
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.19
    Marker Score: 601
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.18
    Marker Score: 206
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.18
    Marker Score: 107
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.18
    Marker Score: 101
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.17
    Marker Score: 89
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.17
    Marker Score: 186
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.16
    Marker Score: 58
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.15
    Marker Score: 56
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.15
    Marker Score: 988
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.15
    Marker Score: 34
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.13
    Marker Score: 123
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.13
    Marker Score: 61
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.12
    Marker Score: 37
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.12
    Marker Score: 42
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.11
    Marker Score: 103
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.11
    Marker Score: 439
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.11
    Marker Score: 29
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.11
    Marker Score: 40
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.11
    Marker Score: 44
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.1
    Marker Score: 72
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.1
    Marker Score: 26

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FGL1 is a member of the fibrinogen-like family of proteins, characterized by its ability to bind to collagen, fibrinogen, and other proteins. The FGL1 protein has a unique structure, comprising two domains, each with a specific binding site. This protein is primarily expressed in the liver, pancreas, and immune cells, suggesting its involvement in tissue-specific functions. **Pathways and Functions:** FGL1 is implicated in several biological pathways, including: 1. **Adaptive Immune Response:** FGL1 is expressed on the surface of immune cells, such as macrophages and granulocytes, and plays a role in modulating T-cell activation. It can bind to CD4+ T cells, influencing their proliferation and differentiation. 2. **Cell-Matrix Adhesion:** FGL1 interacts with collagen, facilitating cell adhesion and migration. This process is crucial for tissue repair, wound healing, and cancer metastasis. 3. **Hepatocyte Proliferation:** FGL1 is overexpressed in the periportal region of hepatocytes, suggesting its involvement in liver regeneration and fibrosis. 4. **Platelet Aggregation:** Although FGL1 does not directly participate in coagulation, it can bind to platelets, influencing their activation and aggregation. **Clinical Significance:** The dysregulation of FGL1 has been implicated in various diseases, including: 1. **Liver Diseases:** FGL1 expression is altered in liver fibrosis, cirrhosis, and hepatocellular carcinoma, suggesting its role in liver regeneration and tumor progression. 2. **Immune-Mediated Disorders:** FGL1 is involved in autoimmune diseases, such as rheumatoid arthritis and lupus, where its dysregulation contributes to immune dysbalance. 3. **Cancer:** FGL1 expression is elevated in various types of cancer, including breast, lung, and colon cancer, where it may promote tumor progression and metastasis. 4. **Cardiovascular Diseases:** FGL1 is also involved in cardiovascular diseases, such as atherosclerosis and hypertension, where its dysregulation contributes to vascular dysfunction. In conclusion, FGL1 is a multifunctional gene with significant implications in immune response, cell adhesion, and tissue repair. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying FGL1's functions and its potential therapeutic applications.

Genular Protein ID: 4183808665

Symbol: FGL1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q08830 A6NKU4 Q4PJH9 Q53YF1 Q8NG32 Q96KW6 Q96QM6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 7 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 5 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8390249

Title: Molecular cloning and initial characterization of a novel fibrinogen-related gene, HFREP-1.

PubMed ID: 8390249

DOI: 10.1006/bbrc.1993.1678

PubMed ID: 11470158

Title: Molecular cloning and functional expression analysis of a cDNA for human hepassocin, a liver-specific protein with hepatocyte mitogenic activity.

PubMed ID: 11470158

DOI: 10.1016/s0167-4781(01)00249-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18039467

Title: Fibrinogen-like protein 1, a hepatocyte derived protein is an acute phase reactant.

PubMed ID: 18039467

DOI: 10.1016/j.bbrc.2007.11.069

PubMed ID: 19880967

Title: Recombinant human hepassocin stimulates proliferation of hepatocytes in vivo and improves survival in rats with fulminant hepatic failure.

PubMed ID: 19880967

DOI: 10.1136/gut.2008.171124

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 30580966

Title: Fibrinogen-like protein 1 is a major immune inhibitory ligand of LAG-3.

PubMed ID: 30580966

DOI: 10.1016/j.cell.2018.11.010

Sequence Information:

  • Length: 312
  • Mass: 36379
  • Checksum: 9297153AEA746C31
  • Sequence:
    • MAKVFSFILV TTALTMGREI SALEDCAQEQ MRLRAQVRLL ETRVKQQQVK IKQLLQENEV 
QFLDKGDENT VIDLGSKRQY ADCSEIFNDG YKLSGFYKIK PLQSPAEFSV YCDMSDGGGW 
TVIQRRSDGS ENFNRGWKDY ENGFGNFVQK HGEYWLGNKN LHFLTTQEDY TLKIDLADFE 
KNSRYAQYKN FKVGDEKNFY ELNIGEYSGT AGDSLAGNFH PEVQWWASHQ RMKFSTWDRD 
HDNYEGNCAE EDQSGWWFNR CHSANLNGVY YSGPYTAKTD NGIVWYTWHG WWYSLKSVVM 
KIRPNDFIPN VI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.