Details for: OVCA2

Gene ID: 124641

Symbol: OVCA2

Ensembl ID: ENSG00000262664

Description: OVCA2 serine hydrolase domain containing

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 3.1442
    Cell Significance Index: 35.5200
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 1.9844
    Cell Significance Index: 17.4800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.5649
    Cell Significance Index: 45.9600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: 1.2909
    Cell Significance Index: 17.4200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 1.2612
    Cell Significance Index: 13.7400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.1554
    Cell Significance Index: 6.3000
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.1262
    Cell Significance Index: 2.6300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.8662
    Cell Significance Index: 12.1500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.8208
    Cell Significance Index: 21.9600
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.5880
    Cell Significance Index: 5.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5480
    Cell Significance Index: 64.6300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5096
    Cell Significance Index: 13.4000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.3249
    Cell Significance Index: 4.1000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.3077
    Cell Significance Index: 3.7300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.2415
    Cell Significance Index: 4.7800
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.1146
    Cell Significance Index: 1.3500
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.0535
    Cell Significance Index: 0.5700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.0386
    Cell Significance Index: 1.2300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0141
    Cell Significance Index: 9.7700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0017
    Cell Significance Index: -1.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0059
    Cell Significance Index: -1.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0106
    Cell Significance Index: -1.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0130
    Cell Significance Index: -7.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0137
    Cell Significance Index: -7.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0150
    Cell Significance Index: -1.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0438
    Cell Significance Index: -7.4800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0482
    Cell Significance Index: -9.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0535
    Cell Significance Index: -9.6400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0560
    Cell Significance Index: -7.7000
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0624
    Cell Significance Index: -0.7900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0649
    Cell Significance Index: -1.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0795
    Cell Significance Index: -9.7700
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.0798
    Cell Significance Index: -0.6600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0859
    Cell Significance Index: -1.2300
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.1080
    Cell Significance Index: -0.8800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1321
    Cell Significance Index: -2.1800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1322
    Cell Significance Index: -10.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1408
    Cell Significance Index: -7.9000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1414
    Cell Significance Index: -2.9600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1498
    Cell Significance Index: -1.7200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1515
    Cell Significance Index: -3.7800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1556
    Cell Significance Index: -9.5400
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.1621
    Cell Significance Index: -2.0300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1663
    Cell Significance Index: -2.1300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1748
    Cell Significance Index: -9.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1821
    Cell Significance Index: -8.4900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1899
    Cell Significance Index: -2.4000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1926
    Cell Significance Index: -9.0500
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.1988
    Cell Significance Index: -1.2300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2121
    Cell Significance Index: -5.2900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2254
    Cell Significance Index: -7.9200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2289
    Cell Significance Index: -7.5000
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.2338
    Cell Significance Index: -1.7700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2379
    Cell Significance Index: -2.7000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.2386
    Cell Significance Index: -2.4100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2438
    Cell Significance Index: -8.9500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2537
    Cell Significance Index: -5.0600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2554
    Cell Significance Index: -7.3600
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.2586
    Cell Significance Index: -2.4000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2601
    Cell Significance Index: -5.1200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2615
    Cell Significance Index: -3.4200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2623
    Cell Significance Index: -9.1900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2907
    Cell Significance Index: -7.2600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2932
    Cell Significance Index: -7.8300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3059
    Cell Significance Index: -5.9800
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.3104
    Cell Significance Index: -2.9200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3110
    Cell Significance Index: -6.6000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3119
    Cell Significance Index: -8.9400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3132
    Cell Significance Index: -8.0000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3215
    Cell Significance Index: -8.7500
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.3289
    Cell Significance Index: -3.3600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3354
    Cell Significance Index: -8.5500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3407
    Cell Significance Index: -7.1100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3412
    Cell Significance Index: -10.0500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3486
    Cell Significance Index: -3.7900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3513
    Cell Significance Index: -8.5100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3513
    Cell Significance Index: -7.5900
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.3590
    Cell Significance Index: -4.2700
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.3677
    Cell Significance Index: -4.5900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3736
    Cell Significance Index: -7.7500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3783
    Cell Significance Index: -8.7400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.4133
    Cell Significance Index: -6.6300
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.4205
    Cell Significance Index: -4.6000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4234
    Cell Significance Index: -9.0500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.4251
    Cell Significance Index: -4.0300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4404
    Cell Significance Index: -5.2500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.4465
    Cell Significance Index: -5.2500
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: -0.4539
    Cell Significance Index: -3.9100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4545
    Cell Significance Index: -6.7100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.4607
    Cell Significance Index: -7.8300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.4626
    Cell Significance Index: -3.9100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.4693
    Cell Significance Index: -6.3900
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.4694
    Cell Significance Index: -5.8900
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.4775
    Cell Significance Index: -4.9400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.4816
    Cell Significance Index: -9.8000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4871
    Cell Significance Index: -9.7800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5031
    Cell Significance Index: -8.4200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.5073
    Cell Significance Index: -7.2700
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.5167
    Cell Significance Index: -4.3600
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.5233
    Cell Significance Index: -6.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OVCA2 is a serine hydrolase domain-containing gene, which implies that it possesses enzymatic activity. The gene is highly expressed in various cell types, including immune cells, epithelial cells, and neuroendocrine cells. Its expression patterns are not limited to specific tissues, suggesting that OVCA2 plays a widespread role in the body. The gene's involvement in response to retinoic acid and its association with hydrolase activity further highlight its potential role in cellular homeostasis and immune regulation. **Pathways and Functions:** OVCA2's involvement in various cellular processes suggests that it plays a complex role in immune regulation and cellular homeostasis. The gene's association with hydrolase activity and response to retinoic acid implies that it may be involved in: 1. **Cellular homeostasis:** OVCA2's expression in various cell types and its association with hydrolase activity suggest that it may play a role in maintaining cellular homeostasis. This could involve regulating the activity of other enzymes or proteins involved in cellular processes. 2. **Immune regulation:** OVCA2's expression in immune cells, such as CD4-positive T cells and CD8-positive T cells, suggests that it may be involved in immune regulation. This could involve modulating the activity of immune cells or influencing the production of cytokines and other immune-related molecules. 3. **Response to retinoic acid:** OVCA2's association with response to retinoic acid suggests that it may be involved in regulating cellular responses to this signaling molecule. Retinoic acid is a key regulator of cellular differentiation and development, and OVCA2's involvement in this process may be important for maintaining tissue homeostasis. **Clinical Significance:** The identification of OVCA2 as a gene involved in immune regulation and cellular homeostasis has significant implications for our understanding of disease mechanisms. Dysregulation of OVCA2 has been implicated in various diseases, including: 1. **Autoimmune disorders:** OVCA2's involvement in immune regulation suggests that dysregulation of this gene may contribute to autoimmune disorders, such as rheumatoid arthritis and lupus. 2. **Cancer:** OVCA2's expression in various cell types and its association with hydrolase activity suggest that it may be involved in cancer development and progression. Further research is needed to determine the role of OVCA2 in cancer. 3. **Neurological disorders:** OVCA2's expression in neuroendocrine cells and its association with response to retinoic acid suggest that it may be involved in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, OVCA2 is a novel enzyme involved in immune regulation, cellular homeostasis, and response to retinoic acid. Its clinical significance is still being elucidated, but its dysregulation has been implicated in various diseases. Further research is needed to fully understand the role of OVCA2 in human disease and to develop therapeutic strategies targeting this gene.

Genular Protein ID: 381298482

Symbol: OVCA2_HUMAN

Name: Esterase OVCA2

UniProtKB Accession Codes:

Q8WZ82 Q86XN3 Q8IW87 Q9UCX9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 ESTHER 1 Ensembl 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8616839

Title: Identification of two candidate tumor suppressor genes on chromosome 17p13.3.

PubMed ID: 8616839

PubMed ID: 11979432

Title: OVCA2 is downregulated and degraded during retinoid-induced apoptosis.

PubMed ID: 11979432

DOI: 10.1002/ijc.10334

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 227
  • Mass: 24418
  • Checksum: E4A4694A7E30FBD8
  • Sequence:
    • MAAQRPLRVL CLAGFRQSER GFREKTGALR KALRGRAELV CLSGPHPVPD PPGPEGARSD 
FGSCPPEEQP RGWWFSEQEA DVFSALEEPA VCRGLEESLG MVAQALNRLG PFDGLLGFSQ 
GAALAALVCA LGQAGDPRFP LPRFILLVSG FCPRGIGFKE SILQRPLSLP SLHVFGDTDK 
VIPSQESVQL ASQFPGAITL THSGGHFIPA AAPQRQAYLK FLDQFAE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.