Details for: SERPINB7

Gene ID: 8710

Symbol: SERPINB7

Ensembl ID: ENSG00000166396

Description: serpin family B member 7

Associated with

  • Cytoplasm
    (GO:0005737)
  • Extracellular space
    (GO:0005615)
  • Negative regulation of endopeptidase activity
    (GO:0010951)
  • Negative regulation of peptidase activity
    (GO:0010466)
  • Positive regulation of collagen biosynthetic process
    (GO:0032967)
  • Positive regulation of glomerular mesangial cell proliferation
    (GO:0072126)
  • Positive regulation of platelet-derived growth factor production
    (GO:0090362)
  • Positive regulation of transforming growth factor beta1 production
    (GO:0032914)
  • Serine-type endopeptidase inhibitor activity
    (GO:0004867)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 12.7723
    Cell Significance Index: 135.6800
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 6.0524
    Cell Significance Index: 18.0000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.3599
    Cell Significance Index: 32.9400
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.1488
    Cell Significance Index: 2.5900
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.8211
    Cell Significance Index: 8.4700
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.6832
    Cell Significance Index: 4.5400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.5620
    Cell Significance Index: -1.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.4143
    Cell Significance Index: 87.2700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1675
    Cell Significance Index: 19.1200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0931
    Cell Significance Index: 1.4400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.0901
    Cell Significance Index: 0.5600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0845
    Cell Significance Index: 1.2100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0682
    Cell Significance Index: 42.6000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0633
    Cell Significance Index: 8.1800
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.0503
    Cell Significance Index: 0.5500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0476
    Cell Significance Index: 0.6500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0303
    Cell Significance Index: 0.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0100
    Cell Significance Index: 1.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0001
    Cell Significance Index: 0.0000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0007
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0008
    Cell Significance Index: -1.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0015
    Cell Significance Index: -0.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0020
    Cell Significance Index: -3.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0023
    Cell Significance Index: -3.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0027
    Cell Significance Index: -3.6500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0030
    Cell Significance Index: -2.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0035
    Cell Significance Index: -0.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0041
    Cell Significance Index: -2.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0047
    Cell Significance Index: -2.9800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0047
    Cell Significance Index: -3.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0060
    Cell Significance Index: -1.2000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0061
    Cell Significance Index: -3.3200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0071
    Cell Significance Index: -1.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0078
    Cell Significance Index: -3.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0082
    Cell Significance Index: -2.3500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0088
    Cell Significance Index: -3.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0127
    Cell Significance Index: -1.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0183
    Cell Significance Index: -2.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0249
    Cell Significance Index: -3.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0255
    Cell Significance Index: -1.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0281
    Cell Significance Index: -3.2300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0336
    Cell Significance Index: -3.4400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0339
    Cell Significance Index: -0.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0340
    Cell Significance Index: -3.5400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0379
    Cell Significance Index: -0.8300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0449
    Cell Significance Index: -0.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0449
    Cell Significance Index: -3.3500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0484
    Cell Significance Index: -2.4500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0539
    Cell Significance Index: -2.2100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0555
    Cell Significance Index: -4.2600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0584
    Cell Significance Index: -3.5900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0584
    Cell Significance Index: -0.8300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0665
    Cell Significance Index: -1.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0687
    Cell Significance Index: -3.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0709
    Cell Significance Index: -3.9800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0771
    Cell Significance Index: -2.2700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0792
    Cell Significance Index: -2.2600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0796
    Cell Significance Index: -1.1800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0817
    Cell Significance Index: -1.6000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0853
    Cell Significance Index: -3.1300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0870
    Cell Significance Index: -2.3300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0879
    Cell Significance Index: -1.8400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0891
    Cell Significance Index: -3.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0927
    Cell Significance Index: -4.1000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0939
    Cell Significance Index: -2.9900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0955
    Cell Significance Index: -3.3200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0962
    Cell Significance Index: -3.1500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0963
    Cell Significance Index: -1.7800
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.0984
    Cell Significance Index: -1.6900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1012
    Cell Significance Index: -2.0600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1039
    Cell Significance Index: -1.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1096
    Cell Significance Index: -4.1500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1127
    Cell Significance Index: -3.2300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1130
    Cell Significance Index: -1.4600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1159
    Cell Significance Index: -1.2000
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.1222
    Cell Significance Index: -1.0100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1237
    Cell Significance Index: -2.0700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1238
    Cell Significance Index: -3.3700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1241
    Cell Significance Index: -3.3200
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1250
    Cell Significance Index: -1.8700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1255
    Cell Significance Index: -3.1300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1273
    Cell Significance Index: -5.5400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1354
    Cell Significance Index: -3.5600
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.1359
    Cell Significance Index: -1.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1371
    Cell Significance Index: -2.9700
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1382
    Cell Significance Index: -1.8100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1396
    Cell Significance Index: -2.7600
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.1405
    Cell Significance Index: -1.9100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1418
    Cell Significance Index: -3.0100
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.1437
    Cell Significance Index: -1.3300
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.1438
    Cell Significance Index: -1.8200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1458
    Cell Significance Index: -2.8500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1481
    Cell Significance Index: -3.2000
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.1484
    Cell Significance Index: -1.9000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1492
    Cell Significance Index: -3.7200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1492
    Cell Significance Index: -2.5100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1557
    Cell Significance Index: -1.0500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1570
    Cell Significance Index: -3.1300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1570
    Cell Significance Index: -4.9700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1582
    Cell Significance Index: -1.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SERPINB7, also known as Serpin B7, is a serpin protein that belongs to the serpin family, which is characterized by its ability to inhibit serine proteases. SERPINB7 is specifically involved in the negative regulation of endopeptidase activity, thereby modulating cellular processes such as cell growth, differentiation, and survival. Its expression is widespread, with significant levels detected in various cell types, including progenitor cells, retinal ganglion cells, and T cells. **Pathways and Functions:** SERPINB7 plays a pivotal role in regulating several cellular processes through its interaction with various signaling pathways. Some of the key pathways and functions of SERPINB7 include: 1. **Negative regulation of endopeptidase activity:** SERPINB7 inhibits the activity of serine proteases, thereby preventing excessive proteolytic activity and maintaining cellular homeostasis. 2. **Positive regulation of collagen biosynthetic process:** SERPINB7 stimulates the production of collagen, a crucial protein for maintaining tissue structure and integrity. 3. **Positive regulation of glomerular mesangial cell proliferation:** SERPINB7 promotes the proliferation of glomerular mesangial cells, which are essential for maintaining kidney function. 4. **Positive regulation of platelet-derived growth factor production:** SERPINB7 stimulates the production of platelet-derived growth factor, a potent mitogen that regulates cell growth and differentiation. 5. **Positive regulation of transforming growth factor beta1 production:** SERPINB7 enhances the production of transforming growth factor beta1, a cytokine involved in cell growth, differentiation, and immune responses. 6. **Serine-type endopeptidase inhibitor activity:** SERPINB7 inhibits the activity of serine proteases, thereby regulating cellular processes such as cell growth, differentiation, and survival. **Significantly Expressed Cells:** SERPINB7 is expressed in a wide range of cell types, including: 1. Progenitor cells 2. Retinal ganglion cells 3. Amacrine cells 4. Blood vessel endothelial cells 5. T cells 6. Lung secretory cells 7. Kidney proximal convoluted tubule epithelial cells 8. Plasma cells 9. Granulocyte monocyte progenitor cells 10. B cells **Clinical Significance:** The dysregulation of SERPINB7 has been implicated in various diseases, including: 1. **Kidney diseases:** Alterations in SERPINB7 expression have been linked to kidney diseases, such as glomerulonephritis and nephrotic syndrome. 2. **Cancer:** SERPINB7 has been identified as a tumor suppressor gene, and its dysregulation has been implicated in various types of cancer, including breast, lung, and colon cancer. 3. **Neurological disorders:** SERPINB7 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Autoimmune diseases:** SERPINB7 has been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. In conclusion, SERPINB7 is a multifunctional protein that plays a critical role in regulating various cellular processes. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying its function and the potential therapeutic applications of SERPINB7.

Genular Protein ID: 4140542070

Symbol: SPB7_HUMAN

Name: Serpin B7

UniProtKB Accession Codes:

O75635 B4DUW8 F5GZC0 Q1ED45 Q3KPG4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 4 ExpressionAtlas 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 4 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9182567

Title: Purification, cDNA cloning, and characterization of a new serpin with megakaryocyte maturation activity.

PubMed ID: 9182567

DOI: 10.1074/jbc.272.24.15373

PubMed ID: 9710452

Title: A mesangium-predominant gene, megsin, is a new serpin upregulated in IgA nephropathy.

PubMed ID: 9710452

DOI: 10.1172/jci2450

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 24207119

Title: Mutations in SERPINB7, encoding a member of the serine protease inhibitor superfamily, cause Nagashima-type palmoplantar keratosis.

PubMed ID: 24207119

DOI: 10.1016/j.ajhg.2013.09.015

Sequence Information:

  • Length: 380
  • Mass: 42905
  • Checksum: 9A2CDB6C63CFF605
  • Sequence:
    • MASLAAANAE FCFNLFREMD DNQGNGNVFF SSLSLFAALA LVRLGAQDDS LSQIDKLLHV 
NTASGYGNSS NSQSGLQSQL KRVFSDINAS HKDYDLSIVN GLFAEKVYGF HKDYIECAEK 
LYDAKVERVD FTNHLEDTRR NINKWVENET HGKIKNVIGE GGISSSAVMV LVNAVYFKGK 
WQSAFTKSET INCHFKSPKC SGKAVAMMHQ ERKFNLSVIE DPSMKILELR YNGGINMYVL 
LPENDLSEIE NKLTFQNLME WTNPRRMTSK YVEVFFPQFK IEKNYEMKQY LRALGLKDIF 
DESKADLSGI ASGGRLYISR MMHKSYIEVT EEGTEATAAT GSNIVEKQLP QSTLFRADHP 
FLFVIRKDDI ILFSGKVSCP

Genular Protein ID: 3333503390

Symbol: A8K3Q8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K3Q8

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 2 InterPro 6 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 380
  • Mass: 42929
  • Checksum: EC7E75D688615C10
  • Sequence:
    • MASLAAANAE FCFNLFREMD DNQGNGNVFF SSLSLFAALA LVRLGAQDDS LSQIDKLLHV 
NTASGYGNSS NSQSGLQSQL KRVFSDINAS HKDYDLSIVN GLFAEKVYGF HKDYIECAEK 
LYDAKVERVD FTNHLEDTRR NINKWVENEI HGKIKNVIGE GGISSSAVMV LVNAVYFKGK 
WQSAFTKSET INCHFKSPKC SGKAVAMMHQ ERKFNLSVIE DPSMKILELR YNGGINMYVL 
LPENDLSEIE NKLTFQNLME WTNPRRMISK YVEVFFPQFK IEKNYEMKQY LRALGLKDIF 
DESKADLSGI ASGGRLYISR MMHKSYIEVT EEGTEATAAT GSNIVEKQLP QSTLFRADHP 
FLFVIRKDDI ILFSGKVSCP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.