Details for: SERPINB7

Gene ID: 8710

Symbol: SERPINB7

Ensembl ID: ENSG00000166396

Description: serpin family B member 7

Associated with

  • Cytoplasm
    (GO:0005737)
  • Extracellular space
    (GO:0005615)
  • Negative regulation of endopeptidase activity
    (GO:0010951)
  • Positive regulation of collagen biosynthetic process
    (GO:0032967)
  • Positive regulation of glomerular mesangial cell proliferation
    (GO:0072126)
  • Positive regulation of platelet-derived growth factor production
    (GO:0090362)
  • Positive regulation of transforming growth factor beta1 production
    (GO:0032914)
  • Serine-type endopeptidase inhibitor activity
    (GO:0004867)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 8.24
    Marker Score: 53,085
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 3.82
    Marker Score: 4,766
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 2.26
    Marker Score: 7,251
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.95
    Marker Score: 1,967
  • Cell Name: T cell (CL0000084)
    Fold Change: 1.71
    Marker Score: 2,956
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.66
    Marker Score: 1,477
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.53
    Marker Score: 3,162
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.37
    Marker Score: 1,525
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.35
    Marker Score: 858
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.16
    Marker Score: 1,102
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 785
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,791
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,016
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.95
    Marker Score: 322
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.95
    Marker Score: 1,109
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.94
    Marker Score: 642
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.94
    Marker Score: 2,727
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,288
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,737
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.88
    Marker Score: 1,662
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,285
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.86
    Marker Score: 7,263
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.85
    Marker Score: 2,513
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.8
    Marker Score: 1,465
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,263
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 703
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.75
    Marker Score: 495
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.68
    Marker Score: 303
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.66
    Marker Score: 1,338
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.64
    Marker Score: 631
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 450
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 232
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.53
    Marker Score: 321
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.52
    Marker Score: 501
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.49
    Marker Score: 134
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 469
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.48
    Marker Score: 7,436
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.47
    Marker Score: 422
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.47
    Marker Score: 270
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 276
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.45
    Marker Score: 504
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.43
    Marker Score: 206
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.43
    Marker Score: 246
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.42
    Marker Score: 680
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.4
    Marker Score: 942
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.39
    Marker Score: 169
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.39
    Marker Score: 504
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 368
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.33
    Marker Score: 481
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.31
    Marker Score: 397
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.27
    Marker Score: 447
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.27
    Marker Score: 130
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.27
    Marker Score: 921
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 91
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.25
    Marker Score: 321
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.24
    Marker Score: 61
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.24
    Marker Score: 1,796
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.24
    Marker Score: 236
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.24
    Marker Score: 139
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.23
    Marker Score: 195
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.23
    Marker Score: 206
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.23
    Marker Score: 120
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.22
    Marker Score: 506
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.22
    Marker Score: 357
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.22
    Marker Score: 56
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.22
    Marker Score: 55
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.21
    Marker Score: 62
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.21
    Marker Score: 94
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.21
    Marker Score: 231
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.21
    Marker Score: 61
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.2
    Marker Score: 847
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.2
    Marker Score: 175
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.2
    Marker Score: 80
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.2
    Marker Score: 63
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.2
    Marker Score: 60
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.2
    Marker Score: 556
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.19
    Marker Score: 59
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.19
    Marker Score: 60
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.19
    Marker Score: 67
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.19
    Marker Score: 59
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.17
    Marker Score: 63
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.17
    Marker Score: 51
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.17
    Marker Score: 526
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.16
    Marker Score: 43
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.16
    Marker Score: 60
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.16
    Marker Score: 56
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.16
    Marker Score: 58
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.16
    Marker Score: 78
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.16
    Marker Score: 56
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.16
    Marker Score: 51
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.15
    Marker Score: 57
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.15
    Marker Score: 119
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.15
    Marker Score: 105
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.15
    Marker Score: 211
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.15
    Marker Score: 101

Other Information

**Key Characteristics:** SERPINB7, also known as Serpin B7, is a serpin protein that belongs to the serpin family, which is characterized by its ability to inhibit serine proteases. SERPINB7 is specifically involved in the negative regulation of endopeptidase activity, thereby modulating cellular processes such as cell growth, differentiation, and survival. Its expression is widespread, with significant levels detected in various cell types, including progenitor cells, retinal ganglion cells, and T cells. **Pathways and Functions:** SERPINB7 plays a pivotal role in regulating several cellular processes through its interaction with various signaling pathways. Some of the key pathways and functions of SERPINB7 include: 1. **Negative regulation of endopeptidase activity:** SERPINB7 inhibits the activity of serine proteases, thereby preventing excessive proteolytic activity and maintaining cellular homeostasis. 2. **Positive regulation of collagen biosynthetic process:** SERPINB7 stimulates the production of collagen, a crucial protein for maintaining tissue structure and integrity. 3. **Positive regulation of glomerular mesangial cell proliferation:** SERPINB7 promotes the proliferation of glomerular mesangial cells, which are essential for maintaining kidney function. 4. **Positive regulation of platelet-derived growth factor production:** SERPINB7 stimulates the production of platelet-derived growth factor, a potent mitogen that regulates cell growth and differentiation. 5. **Positive regulation of transforming growth factor beta1 production:** SERPINB7 enhances the production of transforming growth factor beta1, a cytokine involved in cell growth, differentiation, and immune responses. 6. **Serine-type endopeptidase inhibitor activity:** SERPINB7 inhibits the activity of serine proteases, thereby regulating cellular processes such as cell growth, differentiation, and survival. **Significantly Expressed Cells:** SERPINB7 is expressed in a wide range of cell types, including: 1. Progenitor cells 2. Retinal ganglion cells 3. Amacrine cells 4. Blood vessel endothelial cells 5. T cells 6. Lung secretory cells 7. Kidney proximal convoluted tubule epithelial cells 8. Plasma cells 9. Granulocyte monocyte progenitor cells 10. B cells **Clinical Significance:** The dysregulation of SERPINB7 has been implicated in various diseases, including: 1. **Kidney diseases:** Alterations in SERPINB7 expression have been linked to kidney diseases, such as glomerulonephritis and nephrotic syndrome. 2. **Cancer:** SERPINB7 has been identified as a tumor suppressor gene, and its dysregulation has been implicated in various types of cancer, including breast, lung, and colon cancer. 3. **Neurological disorders:** SERPINB7 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Autoimmune diseases:** SERPINB7 has been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. In conclusion, SERPINB7 is a multifunctional protein that plays a critical role in regulating various cellular processes. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying its function and the potential therapeutic applications of SERPINB7.

Genular Protein ID: 4140542070

Symbol: SPB7_HUMAN

Name: Serpin B7

UniProtKB Accession Codes:

O75635 B4DUW8 F5GZC0 Q1ED45 Q3KPG4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 10 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 4 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9182567

Title: Purification, cDNA cloning, and characterization of a new serpin with megakaryocyte maturation activity.

PubMed ID: 9182567

DOI: 10.1074/jbc.272.24.15373

PubMed ID: 9710452

Title: A mesangium-predominant gene, megsin, is a new serpin upregulated in IgA nephropathy.

PubMed ID: 9710452

DOI: 10.1172/jci2450

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 24207119

Title: Mutations in SERPINB7, encoding a member of the serine protease inhibitor superfamily, cause Nagashima-type palmoplantar keratosis.

PubMed ID: 24207119

DOI: 10.1016/j.ajhg.2013.09.015

Sequence Information:

  • Length: 380
  • Mass: 42905
  • Checksum: 9A2CDB6C63CFF605
  • Sequence:
    • MASLAAANAE FCFNLFREMD DNQGNGNVFF SSLSLFAALA LVRLGAQDDS LSQIDKLLHV 
NTASGYGNSS NSQSGLQSQL KRVFSDINAS HKDYDLSIVN GLFAEKVYGF HKDYIECAEK 
LYDAKVERVD FTNHLEDTRR NINKWVENET HGKIKNVIGE GGISSSAVMV LVNAVYFKGK 
WQSAFTKSET INCHFKSPKC SGKAVAMMHQ ERKFNLSVIE DPSMKILELR YNGGINMYVL 
LPENDLSEIE NKLTFQNLME WTNPRRMTSK YVEVFFPQFK IEKNYEMKQY LRALGLKDIF 
DESKADLSGI ASGGRLYISR MMHKSYIEVT EEGTEATAAT GSNIVEKQLP QSTLFRADHP 
FLFVIRKDDI ILFSGKVSCP

Genular Protein ID: 3333503390

Symbol: A8K3Q8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K3Q8

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 2 GenomeRNAi 1 InterPro 6 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 380
  • Mass: 42929
  • Checksum: EC7E75D688615C10
  • Sequence:
    • MASLAAANAE FCFNLFREMD DNQGNGNVFF SSLSLFAALA LVRLGAQDDS LSQIDKLLHV 
NTASGYGNSS NSQSGLQSQL KRVFSDINAS HKDYDLSIVN GLFAEKVYGF HKDYIECAEK 
LYDAKVERVD FTNHLEDTRR NINKWVENEI HGKIKNVIGE GGISSSAVMV LVNAVYFKGK 
WQSAFTKSET INCHFKSPKC SGKAVAMMHQ ERKFNLSVIE DPSMKILELR YNGGINMYVL 
LPENDLSEIE NKLTFQNLME WTNPRRMISK YVEVFFPQFK IEKNYEMKQY LRALGLKDIF 
DESKADLSGI ASGGRLYISR MMHKSYIEVT EEGTEATAAT GSNIVEKQLP QSTLFRADHP 
FLFVIRKDDI ILFSGKVSCP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.