Details for: EPHA1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 27.9661
Cell Significance Index: -4.3500 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 16.0067
Cell Significance Index: -4.0600 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 3.9785
Cell Significance Index: 65.5600 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 3.5362
Cell Significance Index: -4.3600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 2.2746
Cell Significance Index: 432.8800 - Cell Name: precursor cell (CL0011115)
Fold Change: 1.8963
Cell Significance Index: 14.3800 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 1.8394
Cell Significance Index: 45.8700 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 1.5156
Cell Significance Index: -4.0600 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 1.4651
Cell Significance Index: -4.5000 - Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 1.4647
Cell Significance Index: 1.9000 - Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.3554
Cell Significance Index: 11.2100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.0989
Cell Significance Index: 108.7100 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.9449
Cell Significance Index: 20.4700 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.8112
Cell Significance Index: 48.7000 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.7464
Cell Significance Index: 81.1900 - Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.6802
Cell Significance Index: 6.8200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.6140
Cell Significance Index: 31.9000 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.6042
Cell Significance Index: 98.2800 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.5541
Cell Significance Index: 4.7100 - Cell Name: peg cell (CL4033014)
Fold Change: 0.4424
Cell Significance Index: 10.2200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.4362
Cell Significance Index: 12.1900 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3729
Cell Significance Index: 25.7900 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.2845
Cell Significance Index: 6.0600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2669
Cell Significance Index: 7.6900 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.2536
Cell Significance Index: 3.6100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2275
Cell Significance Index: 10.3100 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.1940
Cell Significance Index: 5.2800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1885
Cell Significance Index: 102.9400 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1852
Cell Significance Index: 167.2200 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.1745
Cell Significance Index: 2.5800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1681
Cell Significance Index: 30.3100 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.1628
Cell Significance Index: 2.4400 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.1557
Cell Significance Index: 1.8100 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1207
Cell Significance Index: 4.2400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1039
Cell Significance Index: 12.7800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0988
Cell Significance Index: 19.6100 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.0952
Cell Significance Index: 0.9900 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0841
Cell Significance Index: 3.9200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0825
Cell Significance Index: 36.4800 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.0673
Cell Significance Index: 0.6200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0648
Cell Significance Index: 1.6200 - Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 0.0531
Cell Significance Index: 0.5900 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0407
Cell Significance Index: 1.3100 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.0376
Cell Significance Index: 0.2500 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0291
Cell Significance Index: 2.0600 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.0252
Cell Significance Index: 0.3900 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0230
Cell Significance Index: 1.0800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0209
Cell Significance Index: 3.5700 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.0202
Cell Significance Index: 0.4200 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0181
Cell Significance Index: 0.3100 - Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.0143
Cell Significance Index: 0.2000 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.0098
Cell Significance Index: 0.4900 - Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.0072
Cell Significance Index: 0.1000 - Cell Name: hepatoblast (CL0005026)
Fold Change: 0.0071
Cell Significance Index: 0.1200 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.0053
Cell Significance Index: 0.6900 - Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.0049
Cell Significance Index: 0.0500 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0015
Cell Significance Index: 0.0400 - Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 0.0013
Cell Significance Index: 0.0000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0006
Cell Significance Index: 0.1300 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0004
Cell Significance Index: -0.7800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0013
Cell Significance Index: -0.9700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0013
Cell Significance Index: -2.3100 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0013
Cell Significance Index: -2.0200 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0025
Cell Significance Index: -3.4400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0027
Cell Significance Index: -1.9600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0042
Cell Significance Index: -3.0800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0047
Cell Significance Index: -0.3500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0047
Cell Significance Index: -2.6300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0057
Cell Significance Index: -3.6000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0068
Cell Significance Index: -0.9900 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0069
Cell Significance Index: -3.1200 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0096
Cell Significance Index: -0.2100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0100
Cell Significance Index: -3.5800 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0103
Cell Significance Index: -1.1800 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0116
Cell Significance Index: -1.3500 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0117
Cell Significance Index: -0.1600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0118
Cell Significance Index: -3.3900 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0152
Cell Significance Index: -0.6200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0207
Cell Significance Index: -4.3700 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.0214
Cell Significance Index: -0.3600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0224
Cell Significance Index: -3.0700 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0278
Cell Significance Index: -0.7100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0308
Cell Significance Index: -3.1500 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0388
Cell Significance Index: -2.3800 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0398
Cell Significance Index: -4.1400 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0401
Cell Significance Index: -4.7300 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0405
Cell Significance Index: -0.6100 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0511
Cell Significance Index: -3.2200 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0545
Cell Significance Index: -0.7800 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0556
Cell Significance Index: -4.4000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0581
Cell Significance Index: -4.4600 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0637
Cell Significance Index: -1.5900 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0642
Cell Significance Index: -1.8900 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0736
Cell Significance Index: -4.7500 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0738
Cell Significance Index: -2.7100 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: -0.0768
Cell Significance Index: -0.5100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0772
Cell Significance Index: -4.3300 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0782
Cell Significance Index: -2.4900 - Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: -0.0789
Cell Significance Index: -1.0100 - Cell Name: respiratory goblet cell (CL0002370)
Fold Change: -0.0805
Cell Significance Index: -0.8300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1810464171
Symbol: EPHA1_HUMAN
Name: Ephrin type-A receptor 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2825356
Title: A novel putative tyrosine kinase receptor encoded by the eph gene.
PubMed ID: 2825356
PubMed ID: 10369740
Title: Genomic structure of the EPHA1 receptor tyrosine kinase gene.
PubMed ID: 10369740
PubMed ID: 18593464
Title: Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.
PubMed ID: 18593464
DOI: 10.1186/ar2447
PubMed ID: 12853948
PubMed ID: 12690205
Title: Human chromosome 7: DNA sequence and biology.
PubMed ID: 12690205
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9267020
Title: Unified nomenclature for Eph family receptors and their ligands, the ephrins.
PubMed ID: 9267020
PubMed ID: 17634955
Title: Ephrin-A1 stimulates migration of CD8+CCR7+ T lymphocytes.
PubMed ID: 17634955
PubMed ID: 19118217
Title: EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility.
PubMed ID: 19118217
DOI: 10.1242/jcs.036467
PubMed ID: 20043122
Title: EphA1 receptor silencing by small interfering RNA has antiangiogenic and antitumor efficacy in hepatocellular carcinoma.
PubMed ID: 20043122
PubMed ID: 20596523
Title: Development and validation of a method for profiling post-translational modification activities using protein microarrays.
PubMed ID: 20596523
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 18728013
Title: Spatial structure and pH-dependent conformational diversity of dimeric transmembrane domain of the receptor tyrosine kinase EphA1.
PubMed ID: 18728013
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
Sequence Information:
- Length: 976
- Mass: 108127
- Checksum: 91EFCA69FFE17826
- Sequence:
MERRWPLGLG LVLLLCAPLP PGARAKEVTL MDTSKAQGEL GWLLDPPKDG WSEQQQILNG TPLYMYQDCP MQGRRDTDHW LRSNWIYRGE EASRVHVELQ FTVRDCKSFP GGAGPLGCKE TFNLLYMESD QDVGIQLRRP LFQKVTTVAA DQSFTIRDLV SGSVKLNVER CSLGRLTRRG LYLAFHNPGA CVALVSVRVF YQRCPETLNG LAQFPDTLPG PAGLVEVAGT CLPHARASPR PSGAPRMHCS PDGEWLVPVG RCHCEPGYEE GGSGEACVAC PSGSYRMDMD TPHCLTCPQQ STAESEGATI CTCESGHYRA PGEGPQVACT GPPSAPRNLS FSASGTQLSL RWEPPADTGG RQDVRYSVRC SQCQGTAQDG GPCQPCGVGV HFSPGARGLT TPAVHVNGLE PYANYTFNVE AQNGVSGLGS SGHASTSVSI SMGHAESLSG LSLRLVKKEP RQLELTWAGS RPRSPGANLT YELHVLNQDE ERYQMVLEPR VLLTELQPDT TYIVRVRMLT PLGPGPFSPD HEFRTSPPVS RGLTGGEIVA VIFGLLLGAA LLLGILVFRS RRAQRQRQQR QRDRATDVDR EDKLWLKPYV DLQAYEDPAQ GALDFTRELD PAWLMVDTVI GEGEFGEVYR GTLRLPSQDC KTVAIKTLKD TSPGGQWWNF LREATIMGQF SHPHILHLEG VVTKRKPIMI ITEFMENGAL DAFLREREDQ LVPGQLVAML QGIASGMNYL SNHNYVHRDL AARNILVNQN LCCKVSDFGL TRLLDDFDGT YETQGGKIPI RWTAPEAIAH RIFTTASDVW SFGIVMWEVL SFGDKPYGEM SNQEVMKSIE DGYRLPPPVD CPAPLYELMK NCWAYDRARR PHFQKLQAHL EQLLANPHSL RTIANFDPRM TLRLPSLSGS DGIPYRTVSE WLESIRMKRY ILHFHSAGLD TMECVLELTA EDLTQMGITL PGHQKRILCS IQGFKD
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.