Details for: EPHA1

Gene ID: 2041

Symbol: EPHA1

Ensembl ID: ENSG00000146904

Description: EPH receptor A1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.11
    Marker Score: 4117
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1
    Marker Score: 8660
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71818
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48043
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2736
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5193
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5283
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 551.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 651
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.71
    Marker Score: 5534.5
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.7
    Marker Score: 2250
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.7
    Marker Score: 279
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2754
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.62
    Marker Score: 680
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.57
    Marker Score: 603
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.49
    Marker Score: 153
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.47
    Marker Score: 3476
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.47
    Marker Score: 318
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 272
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.44
    Marker Score: 1048
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.43
    Marker Score: 705.5
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.43
    Marker Score: 104
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.4
    Marker Score: 3937
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.39
    Marker Score: 1887.5
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.39
    Marker Score: 213
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.38
    Marker Score: 315
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.37
    Marker Score: 249
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.37
    Marker Score: 118
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.34
    Marker Score: 11781
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.34
    Marker Score: 87
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.33
    Marker Score: 88
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.32
    Marker Score: 335
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.32
    Marker Score: 470
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.32
    Marker Score: 358
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.31
    Marker Score: 105
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.3
    Marker Score: 551
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.3
    Marker Score: 385
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.29
    Marker Score: 185
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.28
    Marker Score: 66
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.27
    Marker Score: 251
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.27
    Marker Score: 1710
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.26
    Marker Score: 65
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.26
    Marker Score: 176
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.25
    Marker Score: 94.5
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.25
    Marker Score: 780
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.24
    Marker Score: 578
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.24
    Marker Score: 664
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.23
    Marker Score: 106
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.23
    Marker Score: 412
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.23
    Marker Score: 86
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.23
    Marker Score: 114
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.23
    Marker Score: 226
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.22
    Marker Score: 241
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.22
    Marker Score: 100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.22
    Marker Score: 254
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.22
    Marker Score: 236
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.22
    Marker Score: 307
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.22
    Marker Score: 101
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.22
    Marker Score: 62
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.21
    Marker Score: 925
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.21
    Marker Score: 54
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.21
    Marker Score: 355
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.2
    Marker Score: 79.5
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.2
    Marker Score: 176
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.2
    Marker Score: 61
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.2
    Marker Score: 1287
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2
    Marker Score: 83
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.2
    Marker Score: 138
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.19
    Marker Score: 333
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.19
    Marker Score: 92
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.19
    Marker Score: 191
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.19
    Marker Score: 125
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.17
    Marker Score: 65
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.17
    Marker Score: 61
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.17
    Marker Score: 8971
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.17
    Marker Score: 427
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.17
    Marker Score: 77
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.17
    Marker Score: 545
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.17
    Marker Score: 84
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.16
    Marker Score: 132
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.16
    Marker Score: 94
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.16
    Marker Score: 33
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.16
    Marker Score: 47
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.16
    Marker Score: 336
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.16
    Marker Score: 66
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.16
    Marker Score: 34
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.16
    Marker Score: 77
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.16
    Marker Score: 354
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.16
    Marker Score: 118

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Other Information

## Summary EPHA1 is a cell surface receptor protein that plays a crucial role in various physiological processes, including angiogenesis, cell migration, and tissue development. It is a member of the Eph family of cell surface receptors, which are known for their ability to regulate cell adhesion, migration, and signaling pathways. ## Key characteristics * EPHA1 is a transmembrane protein with a single extracellular domain and a cytoplasmic domain that is involved in signaling. * It is expressed on various cell types, including endothelial cells, epithelial cells, and neurons. * EPHA1 is a key regulator of angiogenesis, as it is expressed in high levels in endothelial cells and is involved in the formation and maintenance of blood vessels. * It is also involved in cell migration, as it is expressed on cells that are migrating along the growth factor EGF. * EPHA1 is a regulator of cell-matrix adhesion, as it is expressed on cells that are in contact with the extracellular matrix. * It is also involved in the regulation of cell proliferation, as it is expressed in cells that are proliferating. ## Pathways and functions * EPHA1 signaling pathway is involved in the regulation of angiogenesis, cell migration, and tissue development. * It is a key regulator of the formation and maintenance of blood vessels, as it is expressed in high levels in endothelial cells. * It is also involved in cell migration, as it is expressed on cells that are migrating along the growth factor EGF. * EPHA1 is also involved in cell-matrix adhesion, as it is expressed on cells that are in contact with the extracellular matrix. * It is also involved in the regulation of cell proliferation, as it is expressed in cells that are proliferating. ## Clinical significance EPHA1 gene mutations have been linked to a number of human diseases, including cancer, cardiovascular disease, and developmental disorders. For example, mutations in the EPHA1 gene have been linked to the development of lung cancer, breast cancer, and leukemia. EPHA1 is an important target for cancer therapy, as it is expressed on cancer cells and is involved in their proliferation and survival. Antibodies against EPHA1 have been shown to be effective in inhibiting cancer growth in preclinical models.

Genular Protein ID: 1810464171

Symbol: EPHA1_HUMAN

Name: Ephrin type-A receptor 1

UniProtKB Accession Codes:

P21709 A1L3V3 B5A966 B5A967 Q15405

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CORUM 1 CPTAC 1 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 2 EMBL 16 EPD 1 Ensembl 2 EvolutionaryTrace 1 GO 23 Gene3D 6 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 19 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 4 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 9 PROSITE-ProRule 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 1 Rhea 3 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 5 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2825356

Title: A novel putative tyrosine kinase receptor encoded by the eph gene.

PubMed ID: 2825356

DOI: 10.1126/science.2825356

PubMed ID: 10369740

Title: Genomic structure of the EPHA1 receptor tyrosine kinase gene.

PubMed ID: 10369740

DOI: 10.1006/mcpr.1999.0228

PubMed ID: 18593464

Title: Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.

PubMed ID: 18593464

DOI: 10.1186/ar2447

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9267020

Title: Unified nomenclature for Eph family receptors and their ligands, the ephrins.

PubMed ID: 9267020

DOI: 10.1016/s0092-8674(00)80500-0

PubMed ID: 17634955

Title: Ephrin-A1 stimulates migration of CD8+CCR7+ T lymphocytes.

PubMed ID: 17634955

DOI: 10.1002/eji.200737111

PubMed ID: 19118217

Title: EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility.

PubMed ID: 19118217

DOI: 10.1242/jcs.036467

PubMed ID: 20043122

Title: EphA1 receptor silencing by small interfering RNA has antiangiogenic and antitumor efficacy in hepatocellular carcinoma.

PubMed ID: 20043122

PubMed ID: 20596523

Title: Development and validation of a method for profiling post-translational modification activities using protein microarrays.

PubMed ID: 20596523

DOI: 10.1371/journal.pone.0011332

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 18728013

Title: Spatial structure and pH-dependent conformational diversity of dimeric transmembrane domain of the receptor tyrosine kinase EphA1.

PubMed ID: 18728013

DOI: 10.1074/jbc.m803089200

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

Sequence Information:

  • Length: 976
  • Mass: 108127
  • Checksum: 91EFCA69FFE17826
  • Sequence:
    • MERRWPLGLG LVLLLCAPLP PGARAKEVTL MDTSKAQGEL GWLLDPPKDG WSEQQQILNG 
TPLYMYQDCP MQGRRDTDHW LRSNWIYRGE EASRVHVELQ FTVRDCKSFP GGAGPLGCKE 
TFNLLYMESD QDVGIQLRRP LFQKVTTVAA DQSFTIRDLV SGSVKLNVER CSLGRLTRRG 
LYLAFHNPGA CVALVSVRVF YQRCPETLNG LAQFPDTLPG PAGLVEVAGT CLPHARASPR 
PSGAPRMHCS PDGEWLVPVG RCHCEPGYEE GGSGEACVAC PSGSYRMDMD TPHCLTCPQQ 
STAESEGATI CTCESGHYRA PGEGPQVACT GPPSAPRNLS FSASGTQLSL RWEPPADTGG 
RQDVRYSVRC SQCQGTAQDG GPCQPCGVGV HFSPGARGLT TPAVHVNGLE PYANYTFNVE 
AQNGVSGLGS SGHASTSVSI SMGHAESLSG LSLRLVKKEP RQLELTWAGS RPRSPGANLT 
YELHVLNQDE ERYQMVLEPR VLLTELQPDT TYIVRVRMLT PLGPGPFSPD HEFRTSPPVS 
RGLTGGEIVA VIFGLLLGAA LLLGILVFRS RRAQRQRQQR QRDRATDVDR EDKLWLKPYV 
DLQAYEDPAQ GALDFTRELD PAWLMVDTVI GEGEFGEVYR GTLRLPSQDC KTVAIKTLKD 
TSPGGQWWNF LREATIMGQF SHPHILHLEG VVTKRKPIMI ITEFMENGAL DAFLREREDQ 
LVPGQLVAML QGIASGMNYL SNHNYVHRDL AARNILVNQN LCCKVSDFGL TRLLDDFDGT 
YETQGGKIPI RWTAPEAIAH RIFTTASDVW SFGIVMWEVL SFGDKPYGEM SNQEVMKSIE 
DGYRLPPPVD CPAPLYELMK NCWAYDRARR PHFQKLQAHL EQLLANPHSL RTIANFDPRM 
TLRLPSLSGS DGIPYRTVSE WLESIRMKRY ILHFHSAGLD TMECVLELTA EDLTQMGITL 
PGHQKRILCS IQGFKD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.