Details for: EPHA1

Gene ID: 2041

Symbol: EPHA1

Ensembl ID: ENSG00000146904

Description: EPH receptor A1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 27.9661
    Cell Significance Index: -4.3500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 16.0067
    Cell Significance Index: -4.0600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 3.9785
    Cell Significance Index: 65.5600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.5362
    Cell Significance Index: -4.3600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.2746
    Cell Significance Index: 432.8800
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.8963
    Cell Significance Index: 14.3800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.8394
    Cell Significance Index: 45.8700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.5156
    Cell Significance Index: -4.0600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.4651
    Cell Significance Index: -4.5000
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 1.4647
    Cell Significance Index: 1.9000
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.3554
    Cell Significance Index: 11.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0989
    Cell Significance Index: 108.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9449
    Cell Significance Index: 20.4700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8112
    Cell Significance Index: 48.7000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7464
    Cell Significance Index: 81.1900
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.6802
    Cell Significance Index: 6.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6140
    Cell Significance Index: 31.9000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6042
    Cell Significance Index: 98.2800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.5541
    Cell Significance Index: 4.7100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4424
    Cell Significance Index: 10.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4362
    Cell Significance Index: 12.1900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3729
    Cell Significance Index: 25.7900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2845
    Cell Significance Index: 6.0600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2669
    Cell Significance Index: 7.6900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.2536
    Cell Significance Index: 3.6100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2275
    Cell Significance Index: 10.3100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1940
    Cell Significance Index: 5.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1885
    Cell Significance Index: 102.9400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1852
    Cell Significance Index: 167.2200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1745
    Cell Significance Index: 2.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1681
    Cell Significance Index: 30.3100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1628
    Cell Significance Index: 2.4400
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.1557
    Cell Significance Index: 1.8100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1207
    Cell Significance Index: 4.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1039
    Cell Significance Index: 12.7800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0988
    Cell Significance Index: 19.6100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0952
    Cell Significance Index: 0.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0841
    Cell Significance Index: 3.9200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0825
    Cell Significance Index: 36.4800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0673
    Cell Significance Index: 0.6200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0648
    Cell Significance Index: 1.6200
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.0531
    Cell Significance Index: 0.5900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0407
    Cell Significance Index: 1.3100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0376
    Cell Significance Index: 0.2500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0291
    Cell Significance Index: 2.0600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0252
    Cell Significance Index: 0.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0230
    Cell Significance Index: 1.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0209
    Cell Significance Index: 3.5700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0202
    Cell Significance Index: 0.4200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0181
    Cell Significance Index: 0.3100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0143
    Cell Significance Index: 0.2000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0098
    Cell Significance Index: 0.4900
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0072
    Cell Significance Index: 0.1000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0071
    Cell Significance Index: 0.1200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0053
    Cell Significance Index: 0.6900
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.0049
    Cell Significance Index: 0.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0015
    Cell Significance Index: 0.0400
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.0013
    Cell Significance Index: 0.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0006
    Cell Significance Index: 0.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0013
    Cell Significance Index: -0.9700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0013
    Cell Significance Index: -2.3100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0013
    Cell Significance Index: -2.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0025
    Cell Significance Index: -3.4400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0027
    Cell Significance Index: -1.9600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0042
    Cell Significance Index: -3.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0047
    Cell Significance Index: -0.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0047
    Cell Significance Index: -2.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0057
    Cell Significance Index: -3.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0068
    Cell Significance Index: -0.9900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0069
    Cell Significance Index: -3.1200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0096
    Cell Significance Index: -0.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0100
    Cell Significance Index: -3.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0103
    Cell Significance Index: -1.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0116
    Cell Significance Index: -1.3500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0117
    Cell Significance Index: -0.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0118
    Cell Significance Index: -3.3900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0152
    Cell Significance Index: -0.6200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0207
    Cell Significance Index: -4.3700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0214
    Cell Significance Index: -0.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0224
    Cell Significance Index: -3.0700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0278
    Cell Significance Index: -0.7100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0308
    Cell Significance Index: -3.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0388
    Cell Significance Index: -2.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0398
    Cell Significance Index: -4.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0401
    Cell Significance Index: -4.7300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0405
    Cell Significance Index: -0.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0511
    Cell Significance Index: -3.2200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0545
    Cell Significance Index: -0.7800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0556
    Cell Significance Index: -4.4000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0581
    Cell Significance Index: -4.4600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0637
    Cell Significance Index: -1.5900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0642
    Cell Significance Index: -1.8900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0736
    Cell Significance Index: -4.7500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0738
    Cell Significance Index: -2.7100
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0768
    Cell Significance Index: -0.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0772
    Cell Significance Index: -4.3300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0782
    Cell Significance Index: -2.4900
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0789
    Cell Significance Index: -1.0100
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.0805
    Cell Significance Index: -0.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Receptor Tyrosine Kinase (RTK):** EPHA1 belongs to the ephrin receptor family, which consists of 7 members. These receptors are characterized by their ability to bind ephrin ligands, leading to the activation of downstream signaling pathways. 2. **Ephrin-Ephrin Signaling:** EPHA1 interacts with ephrin ligands to initiate a signaling cascade that regulates various cellular processes, including cell migration, proliferation, and differentiation. 3. **Diverse Expression Patterns:** EPHA1 is expressed in a wide range of cell types, including epithelial cells, neurons, and stem cells, suggesting its involvement in various developmental and physiological processes. 4. **Regulation of Cell Migration and Proliferation:** EPHA1 plays a crucial role in regulating cell migration and proliferation, which are essential for tissue development, repair, and homeostasis. **Pathways and Functions:** 1. **Angiogenesis:** EPHA1 is involved in the regulation of angiogenesis, a process critical for tissue development and repair. 2. **Axon Guidance:** EPHA1 also plays a role in axon guidance, a process that regulates the migration and branching of axons during neural development. 3. **Cell Surface Receptor Signaling Pathway:** EPHA1 is part of the cell surface receptor signaling pathway, which involves the activation of downstream signaling molecules to regulate cellular responses. 4. **Developmental Biology:** EPHA1 is involved in various developmental processes, including neural development, epithelial development, and stem cell maintenance. 5. **Stress Fiber Assembly:** EPHA1 regulates stress fiber assembly, a process critical for cell migration and adhesion. **Clinical Significance:** 1. **Cancer:** Aberrant EPHA1 expression has been implicated in various cancers, including breast cancer, colon cancer, and leukemia. 2. **Neurological Disorders:** EPHA1 has been linked to neurological disorders, such as Alzheimer's disease, Parkinson's disease, and schizophrenia. 3. **Cardiovascular Diseases:** EPHA1 has been implicated in cardiovascular diseases, including atherosclerosis and hypertension. 4. **Regenerative Medicine:** EPHA1 has the potential to be used as a therapeutic target for regenerative medicine, particularly in the development of stem cell therapies. In conclusion, EPHA1 is a critical gene involved in regulating various cellular processes, including cell signaling, angiogenesis, and developmental biology. Its dysregulation has been implicated in various diseases, making it an important target for therapeutic interventions. Further research on EPHA1 is necessary to fully understand its mechanisms of action and its role in human disease.

Genular Protein ID: 1810464171

Symbol: EPHA1_HUMAN

Name: Ephrin type-A receptor 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2825356

Title: A novel putative tyrosine kinase receptor encoded by the eph gene.

PubMed ID: 2825356

DOI: 10.1126/science.2825356

PubMed ID: 10369740

Title: Genomic structure of the EPHA1 receptor tyrosine kinase gene.

PubMed ID: 10369740

DOI: 10.1006/mcpr.1999.0228

PubMed ID: 18593464

Title: Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.

PubMed ID: 18593464

DOI: 10.1186/ar2447

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9267020

Title: Unified nomenclature for Eph family receptors and their ligands, the ephrins.

PubMed ID: 9267020

DOI: 10.1016/s0092-8674(00)80500-0

PubMed ID: 17634955

Title: Ephrin-A1 stimulates migration of CD8+CCR7+ T lymphocytes.

PubMed ID: 17634955

DOI: 10.1002/eji.200737111

PubMed ID: 19118217

Title: EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility.

PubMed ID: 19118217

DOI: 10.1242/jcs.036467

PubMed ID: 20043122

Title: EphA1 receptor silencing by small interfering RNA has antiangiogenic and antitumor efficacy in hepatocellular carcinoma.

PubMed ID: 20043122

PubMed ID: 20596523

Title: Development and validation of a method for profiling post-translational modification activities using protein microarrays.

PubMed ID: 20596523

DOI: 10.1371/journal.pone.0011332

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 18728013

Title: Spatial structure and pH-dependent conformational diversity of dimeric transmembrane domain of the receptor tyrosine kinase EphA1.

PubMed ID: 18728013

DOI: 10.1074/jbc.m803089200

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

Sequence Information:

  • Length: 976
  • Mass: 108127
  • Checksum: 91EFCA69FFE17826
  • Sequence:
  • MERRWPLGLG LVLLLCAPLP PGARAKEVTL MDTSKAQGEL GWLLDPPKDG WSEQQQILNG 
    TPLYMYQDCP MQGRRDTDHW LRSNWIYRGE EASRVHVELQ FTVRDCKSFP GGAGPLGCKE 
    TFNLLYMESD QDVGIQLRRP LFQKVTTVAA DQSFTIRDLV SGSVKLNVER CSLGRLTRRG 
    LYLAFHNPGA CVALVSVRVF YQRCPETLNG LAQFPDTLPG PAGLVEVAGT CLPHARASPR 
    PSGAPRMHCS PDGEWLVPVG RCHCEPGYEE GGSGEACVAC PSGSYRMDMD TPHCLTCPQQ 
    STAESEGATI CTCESGHYRA PGEGPQVACT GPPSAPRNLS FSASGTQLSL RWEPPADTGG 
    RQDVRYSVRC SQCQGTAQDG GPCQPCGVGV HFSPGARGLT TPAVHVNGLE PYANYTFNVE 
    AQNGVSGLGS SGHASTSVSI SMGHAESLSG LSLRLVKKEP RQLELTWAGS RPRSPGANLT 
    YELHVLNQDE ERYQMVLEPR VLLTELQPDT TYIVRVRMLT PLGPGPFSPD HEFRTSPPVS 
    RGLTGGEIVA VIFGLLLGAA LLLGILVFRS RRAQRQRQQR QRDRATDVDR EDKLWLKPYV 
    DLQAYEDPAQ GALDFTRELD PAWLMVDTVI GEGEFGEVYR GTLRLPSQDC KTVAIKTLKD 
    TSPGGQWWNF LREATIMGQF SHPHILHLEG VVTKRKPIMI ITEFMENGAL DAFLREREDQ 
    LVPGQLVAML QGIASGMNYL SNHNYVHRDL AARNILVNQN LCCKVSDFGL TRLLDDFDGT 
    YETQGGKIPI RWTAPEAIAH RIFTTASDVW SFGIVMWEVL SFGDKPYGEM SNQEVMKSIE 
    DGYRLPPPVD CPAPLYELMK NCWAYDRARR PHFQKLQAHL EQLLANPHSL RTIANFDPRM 
    TLRLPSLSGS DGIPYRTVSE WLESIRMKRY ILHFHSAGLD TMECVLELTA EDLTQMGITL 
    PGHQKRILCS IQGFKD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.