Details for: JRK

Gene ID: 8629

Symbol: JRK

Ensembl ID: ENSG00000234616

Description: Jrk helix-turn-helix protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 22.5473
    Cell Significance Index: -9.1600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 9.6885
    Cell Significance Index: -9.2500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.5579
    Cell Significance Index: -12.2100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.6409
    Cell Significance Index: 27.0400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5761
    Cell Significance Index: 56.9900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4768
    Cell Significance Index: 430.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4727
    Cell Significance Index: 94.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4214
    Cell Significance Index: 21.8900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3968
    Cell Significance Index: 274.4400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3784
    Cell Significance Index: 41.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3361
    Cell Significance Index: 66.7100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3323
    Cell Significance Index: 15.0600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3139
    Cell Significance Index: 51.0500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2916
    Cell Significance Index: 52.5700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2784
    Cell Significance Index: 8.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2691
    Cell Significance Index: 7.5200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2396
    Cell Significance Index: 27.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2322
    Cell Significance Index: 5.0300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1713
    Cell Significance Index: 11.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1574
    Cell Significance Index: 56.4700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1403
    Cell Significance Index: 3.7600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1391
    Cell Significance Index: 8.7700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1255
    Cell Significance Index: 7.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1216
    Cell Significance Index: 16.7100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0974
    Cell Significance Index: 7.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0923
    Cell Significance Index: 11.3500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0909
    Cell Significance Index: 1.2400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0893
    Cell Significance Index: 1.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0891
    Cell Significance Index: 16.9500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0466
    Cell Significance Index: 25.4300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0446
    Cell Significance Index: 2.0800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0430
    Cell Significance Index: 1.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0429
    Cell Significance Index: 2.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0423
    Cell Significance Index: 4.3200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0401
    Cell Significance Index: 17.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0367
    Cell Significance Index: 1.2900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0292
    Cell Significance Index: 0.6400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0281
    Cell Significance Index: 51.7400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0196
    Cell Significance Index: 30.1800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0180
    Cell Significance Index: 0.6800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0172
    Cell Significance Index: 0.8700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0133
    Cell Significance Index: 25.0900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0052
    Cell Significance Index: 0.3500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0039
    Cell Significance Index: 0.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0018
    Cell Significance Index: 2.4300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0010
    Cell Significance Index: 0.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0009
    Cell Significance Index: -0.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0015
    Cell Significance Index: -0.9600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0032
    Cell Significance Index: -2.3800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0109
    Cell Significance Index: -4.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0111
    Cell Significance Index: -1.8900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0122
    Cell Significance Index: -1.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0135
    Cell Significance Index: -10.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0140
    Cell Significance Index: -10.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0143
    Cell Significance Index: -8.0600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0150
    Cell Significance Index: -0.4000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0159
    Cell Significance Index: -1.8700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0179
    Cell Significance Index: -0.9300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0227
    Cell Significance Index: -2.9300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0253
    Cell Significance Index: -1.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0294
    Cell Significance Index: -3.3700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0330
    Cell Significance Index: -9.5000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0331
    Cell Significance Index: -0.8700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0349
    Cell Significance Index: -1.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0435
    Cell Significance Index: -1.5100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0536
    Cell Significance Index: -1.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0585
    Cell Significance Index: -12.3200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0663
    Cell Significance Index: -0.9500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0749
    Cell Significance Index: -1.1200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0808
    Cell Significance Index: -1.7200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0820
    Cell Significance Index: -1.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0896
    Cell Significance Index: -4.2100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0975
    Cell Significance Index: -7.2700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1003
    Cell Significance Index: -10.4500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1061
    Cell Significance Index: -2.0700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1068
    Cell Significance Index: -3.4200
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.1198
    Cell Significance Index: -0.2700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1234
    Cell Significance Index: -9.7700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1325
    Cell Significance Index: -1.8600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1341
    Cell Significance Index: -8.2200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1621
    Cell Significance Index: -4.1400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1682
    Cell Significance Index: -3.5700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1741
    Cell Significance Index: -2.1600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1777
    Cell Significance Index: -5.6600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1810
    Cell Significance Index: -5.3300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1844
    Cell Significance Index: -4.7400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1935
    Cell Significance Index: -4.0500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2015
    Cell Significance Index: -2.8900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2046
    Cell Significance Index: -6.7000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2081
    Cell Significance Index: -7.2900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2134
    Cell Significance Index: -3.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2402
    Cell Significance Index: -4.0200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2406
    Cell Significance Index: -5.7700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2433
    Cell Significance Index: -4.8100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2473
    Cell Significance Index: -6.1700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2499
    Cell Significance Index: -7.1300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2525
    Cell Significance Index: -9.2700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2640
    Cell Significance Index: -5.3000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2777
    Cell Significance Index: -6.0000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.2815
    Cell Significance Index: -3.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The JRK protein belongs to the helix-turn-helix (HTH) family of transcription factors, which play a crucial role in regulating gene expression in response to environmental cues. The JRK protein's structure, comprising a DNA-binding domain and a transcriptional activation domain, enables it to interact with specific DNA sequences and modulate the expression of target genes. The protein's expression pattern, which includes various cell types involved in immune responses, suggests its potential role in regulating immune cell development and function. **Pathways and Functions:** The JRK protein is implicated in the positive regulation of the canonical Wnt signaling pathway, which is a critical signaling cascade involved in cell proliferation, differentiation, and survival. The Wnt pathway is also known to play a role in immune system development and homeostasis. The JRK protein's interaction with the Wnt signaling pathway suggests its involvement in regulating immune cell development, particularly in the context of stem cell maintenance and differentiation. Additionally, the JRK protein's expression in various cell types, including tracheal goblet cells and intestinal epithelial cells, highlights its potential role in maintaining epithelial barrier function and immune tolerance. **Clinical Significance:** Dysregulation of the JRK protein has been implicated in various immune-related disorders, including inflammatory bowel disease (IBD), autoimmune diseases, and cancer. The JRK protein's involvement in the Wnt signaling pathway and its expression in immune cells suggest its potential as a therapeutic target for modulating immune responses. Furthermore, the JRK protein's expression in epithelial cells highlights its potential role in maintaining epithelial barrier function and immune tolerance, underscoring the importance of this protein in preventing immune-mediated tissue damage. In conclusion, the JRK helix-turn-helix protein is a transcription factor that plays a critical role in regulating immune cell development, homeostasis, and function. Its involvement in the Wnt signaling pathway and expression in various cell types involved in immune responses underscores its potential as a therapeutic target for modulating immune responses and preventing immune-related disorders. Further research is needed to fully elucidate the JRK protein's role in the immune system and to explore its potential as a therapeutic target.

Genular Protein ID: 3222137420

Symbol: JERKY_HUMAN

Name: N/A

UniProtKB Accession Codes:

O75564 D3DWI5 O75565 Q86XJ5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 4 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 6 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9675132

Title: JH8, a gene highly homologous to the mouse jerky gene, maps to the region for childhood absence epilepsy on 8q24.

PubMed ID: 9675132

DOI: 10.1006/bbrc.1998.8947

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 556
  • Mass: 61815
  • Checksum: B6D0E018C016335A
  • Sequence:
    • MASKPAAGKS RGEKRKRVVL TLKEKIDICT RLEKGESRKA LMQEYNVGMS TLYDIRAHKA 
QLLRFFASSD SNKALEQRRT LHTPKLEHLD RVLYEWFLGK RSEGVPVSGP MLIEKAKDFY 
EQMQLTEPCV FSGGWLWRFK ARHGIKKLDA SSEKQSADHQ AAEQFCAFFR SLAAEHGLSA 
EQVYNADETG LFWRCLPNPT PEGGAVPGPK QGKDRLTVLM CANATGSHRL KPLAIGKCSG 
PRAFKGIQHL PVAYKAQGNA WVDKEIFSDW FHHIFVPSVR EHFRTIGLPE DSKAVLLLDS 
SRAHPQEAEL VSSNVFTIFL PASVASLVQP MEQGIRRDFM RNFINPPVPL QGPHARYNMN 
DAIFSVACAW NAVPSHVFRR AWRKLWPSVA FAEGSSSEEE LEAECFPVKP HNKSFAHILE 
LVKEGSSCPG QLRQRQAASW GVAGREAEGG RPPAATSPAE VVWSSEKTPK ADQDGRGDPG 
EGEEVAWEQA AVAFDAVLRF AERQPCFSAQ EVGQLRALRA VFRSQQQETV GLEDVVVTSP 
EELAIPKCCL EASTET

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.