Details for: CYP26A1

Gene ID: 1592

Symbol: CYP26A1

Ensembl ID: ENSG00000095596

Description: cytochrome P450 family 26 subfamily A member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 16.7164
    Cell Significance Index: -4.2400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 9.5998
    Cell Significance Index: -3.9000
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 6.7608
    Cell Significance Index: 5.1600
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 5.4534
    Cell Significance Index: 43.3900
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 1.3035
    Cell Significance Index: 9.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5336
    Cell Significance Index: 7.2800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.4654
    Cell Significance Index: 7.2000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.3429
    Cell Significance Index: 5.4400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.3027
    Cell Significance Index: 4.3400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.2227
    Cell Significance Index: 3.1700
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.1881
    Cell Significance Index: 1.4200
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.0302
    Cell Significance Index: 0.2600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0103
    Cell Significance Index: 0.4500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0065
    Cell Significance Index: 4.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0063
    Cell Significance Index: 9.6400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0003
    Cell Significance Index: -0.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0009
    Cell Significance Index: -0.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0013
    Cell Significance Index: -1.8000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0021
    Cell Significance Index: -3.9100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0057
    Cell Significance Index: -3.6200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0069
    Cell Significance Index: -0.8800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0078
    Cell Significance Index: -4.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0079
    Cell Significance Index: -5.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0096
    Cell Significance Index: -3.4500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0117
    Cell Significance Index: -1.6000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0130
    Cell Significance Index: -5.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0132
    Cell Significance Index: -2.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0137
    Cell Significance Index: -3.9500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0144
    Cell Significance Index: -1.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0148
    Cell Significance Index: -0.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0186
    Cell Significance Index: -3.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0197
    Cell Significance Index: -3.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0208
    Cell Significance Index: -2.5600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0228
    Cell Significance Index: -3.3200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0248
    Cell Significance Index: -1.3000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0276
    Cell Significance Index: -3.2200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0336
    Cell Significance Index: -2.1200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0373
    Cell Significance Index: -2.2900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0381
    Cell Significance Index: -6.5000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0428
    Cell Significance Index: -1.4000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0433
    Cell Significance Index: -4.9600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0443
    Cell Significance Index: -5.7200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0501
    Cell Significance Index: -2.6100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0590
    Cell Significance Index: -3.9700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0613
    Cell Significance Index: -1.6400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0614
    Cell Significance Index: -1.6400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0645
    Cell Significance Index: -1.6100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0704
    Cell Significance Index: -0.7300
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: -0.0741
    Cell Significance Index: -0.8000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0750
    Cell Significance Index: -2.3900
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0767
    Cell Significance Index: -0.5900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0780
    Cell Significance Index: -5.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0819
    Cell Significance Index: -3.8500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0829
    Cell Significance Index: -1.6400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0869
    Cell Significance Index: -2.2300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0871
    Cell Significance Index: -4.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0931
    Cell Significance Index: -4.1200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1087
    Cell Significance Index: -3.4800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1091
    Cell Significance Index: -4.1300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1133
    Cell Significance Index: -3.9700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1192
    Cell Significance Index: -3.5100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1194
    Cell Significance Index: -3.2000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1227
    Cell Significance Index: -2.6100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1233
    Cell Significance Index: -2.7000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1258
    Cell Significance Index: -2.5600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1272
    Cell Significance Index: -3.6300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1318
    Cell Significance Index: -3.1600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1327
    Cell Significance Index: -4.8700
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1329
    Cell Significance Index: -1.1300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1347
    Cell Significance Index: -4.2600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1377
    Cell Significance Index: -2.3200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1388
    Cell Significance Index: -3.6500
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.1470
    Cell Significance Index: -1.4800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1551
    Cell Significance Index: -1.8100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1559
    Cell Significance Index: -8.1000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1578
    Cell Significance Index: -4.0300
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1585
    Cell Significance Index: -0.8300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1606
    Cell Significance Index: -4.0100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1705
    Cell Significance Index: -2.8100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1740
    Cell Significance Index: -3.7200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1746
    Cell Significance Index: -2.4500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1781
    Cell Significance Index: -2.0200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1824
    Cell Significance Index: -2.3600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1843
    Cell Significance Index: -2.7200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1858
    Cell Significance Index: -2.2200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1902
    Cell Significance Index: -4.1100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1919
    Cell Significance Index: -4.8900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1938
    Cell Significance Index: -2.2300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1957
    Cell Significance Index: -5.6100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1962
    Cell Significance Index: -4.1000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1989
    Cell Significance Index: -2.5200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2032
    Cell Significance Index: -4.0800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2049
    Cell Significance Index: -3.4300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2069
    Cell Significance Index: -4.3300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2087
    Cell Significance Index: -4.0800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2098
    Cell Significance Index: -5.1200
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.2118
    Cell Significance Index: -1.5400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2139
    Cell Significance Index: -4.2100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2217
    Cell Significance Index: -4.4200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2235
    Cell Significance Index: -4.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Substrate specificity:** CYP26A1 is a 4-hydroxylase and 18-hydroxylase, responsible for converting RA into 4-hydroxyretinonic acid and 18-hydroxyretinonic acid, respectively. 2. **Tissue distribution:** CYP26A1 is highly expressed in tissues involved in immune responses, such as dendritic cells and granulocytes, as well as in tissues involved in development and differentiation, including the respiratory epithelium and the nervous system. 3. **Regulatory mechanisms:** CYP26A1 is negatively regulated by RA, indicating a feedback mechanism to prevent excessive RA-mediated effects. 4. **Metabolic pathways:** CYP26A1 is involved in various metabolic pathways, including the RA biosynthesis pathway, RA catabolic process, and xenobiotic metabolism. **Pathways and Functions:** 1. **Retinoic acid metabolism:** CYP26A1 is responsible for the 4-hydroxylation and 18-hydroxylation of RA, converting it into inactive metabolites. 2. **Developmental processes:** RA signaling is crucial for embryonic development, and CYP26A1 plays a role in regulating RA levels during development. 3. **Immune responses:** CYP26A1 is involved in immune responses, particularly in dendritic cells and granulocytes, where it helps regulate RA-mediated effects. 4. **Neurological functions:** CYP26A1 is expressed in the nervous system, where it may play a role in regulating RA-mediated effects in neural development and function. **Clinical Significance:** 1. **Cancer:** Abnormal expression of CYP26A1 has been implicated in various cancers, where RA signaling is often dysregulated. 2. **Developmental disorders:** Alterations in CYP26A1 expression have been linked to developmental disorders, such as craniosynostosis and retinoblastoma. 3. **Immunological disorders:** CYP26A1 may play a role in immunological disorders, such as autoimmune diseases, where RA signaling is often dysregulated. 4. **Neurological disorders:** CYP26A1 may be involved in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where RA signaling is often dysregulated. In conclusion, CYP26A1 is a critical enzyme involved in the metabolism of retinoic acid, playing a key role in regulating RA levels during development, immune responses, and neurological functions. Abnormal expression of CYP26A1 has been implicated in various diseases, highlighting the importance of this enzyme in maintaining tissue homeostasis and preventing excessive RA-mediated effects.

Genular Protein ID: 1311924124

Symbol: CP26A_HUMAN

Name: Cytochrome P450 26A1

UniProtKB Accession Codes:

O43174 B3KNI4 Q5VXH9 Q5VXI0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 24 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 Rhea 12 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9228017

Title: cDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450.

PubMed ID: 9228017

DOI: 10.1074/jbc.272.30.18538

PubMed ID: 9716180

Title: Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific for all-trans-RA and can be induced through RA receptors in human breast and colon carcinoma cells.

PubMed ID: 9716180

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 9826557

Title: Expression of cytochrome P450RAI (CYP26) in human fetal hepatic and cephalic tissues.

PubMed ID: 9826557

DOI: 10.1006/bbrc.1998.9659

PubMed ID: 22020119

Title: Comparison of the function and expression of CYP26A1 and CYP26B1, the two retinoic acid hydroxylases.

PubMed ID: 22020119

DOI: 10.1016/j.bcp.2011.10.007

PubMed ID: 26937021

Title: Identification of tazarotenic acid as the first xenobiotic substrate of human retinoic acid hydroxylase CYP26A1 and CYP26B1.

PubMed ID: 26937021

DOI: 10.1124/jpet.116.232637

Sequence Information:

  • Length: 497
  • Mass: 56199
  • Checksum: 834318FA493E76D4
  • Sequence:
    • MGLPALLASA LCTFVLPLLL FLAAIKLWDL YCVSGRDRSC ALPLPPGTMG FPFFGETLQM 
VLQRRKFLQM KRRKYGFIYK THLFGRPTVR VMGADNVRRI LLGEHRLVSV HWPASVRTIL 
GSGCLSNLHD SSHKQRKKVI MRAFSREALE CYVPVITEEV GSSLEQWLSC GERGLLVYPE 
VKRLMFRIAM RILLGCEPQL AGDGDSEQQL VEAFEEMTRN LFSLPIDVPF SGLYRGMKAR 
NLIHARIEQN IRAKICGLRA SEAGQGCKDA LQLLIEHSWE RGERLDMQAL KQSSTELLFG 
GHETTASAAT SLITYLGLYP HVLQKVREEL KSKGLLCKSN QDNKLDMEIL EQLKYIGCVI 
KETLRLNPPV PGGFRVALKT FELNGYQIPK GWNVIYSICD THDVAEIFTN KEEFNPDRFM 
LPHPEDASRF SFIPFGGGLR SCVGKEFAKI LLKIFTVELA RHCDWQLLNG PPTMKTSPTV 
YPVDNLPARF THFHGEI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.