Details for: CYP26A1

Gene ID: 1592

Symbol: CYP26A1

Ensembl ID: ENSG00000095596

Description: cytochrome P450 family 26 subfamily A member 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 7.62
    Marker Score: 10943
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.8
    Marker Score: 1244
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 1.63
    Marker Score: 4605
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 876
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.08
    Marker Score: 1890
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 802
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.03
    Marker Score: 2529
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71834
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48059
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.96
    Marker Score: 2434
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5349
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.87
    Marker Score: 1645
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 493
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.82
    Marker Score: 1175
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.8
    Marker Score: 2200
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.78
    Marker Score: 1205
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.72
    Marker Score: 1158
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 181
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.66
    Marker Score: 1336
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.63
    Marker Score: 501
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.58
    Marker Score: 339
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.56
    Marker Score: 8698
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.55
    Marker Score: 1580
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.53
    Marker Score: 3973
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.51
    Marker Score: 213
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.5
    Marker Score: 4310
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.46
    Marker Score: 279
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.46
    Marker Score: 945.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.42
    Marker Score: 443
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.4
    Marker Score: 2639
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.39
    Marker Score: 712
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.38
    Marker Score: 529
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.35
    Marker Score: 102
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.33
    Marker Score: 407
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.29
    Marker Score: 154.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.29
    Marker Score: 138
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.29
    Marker Score: 198
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.26
    Marker Score: 253.5
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.25
    Marker Score: 4951
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.23
    Marker Score: 140
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.22
    Marker Score: 137
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.21
    Marker Score: 120
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.21
    Marker Score: 98
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.21
    Marker Score: 184
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.2
    Marker Score: 134
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.18
    Marker Score: 81
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.17
    Marker Score: 1596
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.16
    Marker Score: 155
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.15
    Marker Score: 84
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.14
    Marker Score: 1344
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.14
    Marker Score: 166
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.14
    Marker Score: 151
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.13
    Marker Score: 85
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.13
    Marker Score: 149
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.13
    Marker Score: 206
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.13
    Marker Score: 132
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.12
    Marker Score: 40
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.12
    Marker Score: 80
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.12
    Marker Score: 103.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.12
    Marker Score: 236
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.12
    Marker Score: 117
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.12
    Marker Score: 111
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.11
    Marker Score: 88
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.11
    Marker Score: 141
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.11
    Marker Score: 257
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 0.1
    Marker Score: 33
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.1
    Marker Score: 51
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.1
    Marker Score: 131
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.1
    Marker Score: 68
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.1
    Marker Score: 486
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.09
    Marker Score: 96
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.09
    Marker Score: 268
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.09
    Marker Score: 101
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.09
    Marker Score: 163.5
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.09
    Marker Score: 27
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.08
    Marker Score: 953
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.08
    Marker Score: 33
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.08
    Marker Score: 224
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.07
    Marker Score: 990
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.07
    Marker Score: 37
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.07
    Marker Score: 68
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.07
    Marker Score: 15
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.07
    Marker Score: 15
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.07
    Marker Score: 59
  • Cell Name: CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human (CL0001074)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.06
    Marker Score: 2307
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.06
    Marker Score: 193
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.06
    Marker Score: 16

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Other Information

**Key characteristics:** - It is a member of the cytochrome P450 family, a superfamily of enzymes that play crucial roles in various metabolic pathways. - It is expressed in a wide range of cell types, including respiratory cells, dendritic cells, and epithelial cells. - It is responsible for the metabolism of ATRA and other retinoids, including retinoic acid 13-cis-retinoic acid (RAA). **Pathways and functions:** - CYP26A1 is involved in multiple pathways: - All-trans retinoic acid 4-hydrolase activity: It catalyzes the conversion of ATRA into 13-cis-RAA, which is a more potent form of ATRA that is involved in various cellular processes. - All-trans retinoic acid 18-hydroxylase activity: It catalyzes the conversion of ATRA into 11-cis-RAA, which is a less potent form of ATRA that is involved in differentiation and tissue development. - Biological oxidations: It participates in various biological oxidations, including the metabolism of other retinoids, such as 11-cis-RAA. - It plays a crucial role in maintaining the integrity and function of the eye, hair, and skin. **Clinical significance:** - Mutations in the CYP26A1 gene have been linked to several eye diseases, including retinitis pigmentosa, a degenerative eye disease that affects the retina and leads to night blindness. - Targeting CYP26A1 with drugs can be used as a therapeutic strategy for these eye diseases. **Other important points:** - CYP26A1 is a highly conserved protein, with a significant expression in the human retina. - It is a well-characterized protein that has been extensively studied for its role in eye development and function.

Genular Protein ID: 1311924124

Symbol: CP26A_HUMAN

Name: Cytochrome P450 26A1

UniProtKB Accession Codes:

O43174 B3KNI4 Q5VXH9 Q5VXI0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 24 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 5 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 Rhea 12 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SwissLipids 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9228017

Title: cDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450.

PubMed ID: 9228017

DOI: 10.1074/jbc.272.30.18538

PubMed ID: 9716180

Title: Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific for all-trans-RA and can be induced through RA receptors in human breast and colon carcinoma cells.

PubMed ID: 9716180

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 9826557

Title: Expression of cytochrome P450RAI (CYP26) in human fetal hepatic and cephalic tissues.

PubMed ID: 9826557

DOI: 10.1006/bbrc.1998.9659

PubMed ID: 22020119

Title: Comparison of the function and expression of CYP26A1 and CYP26B1, the two retinoic acid hydroxylases.

PubMed ID: 22020119

DOI: 10.1016/j.bcp.2011.10.007

PubMed ID: 26937021

Title: Identification of tazarotenic acid as the first xenobiotic substrate of human retinoic acid hydroxylase CYP26A1 and CYP26B1.

PubMed ID: 26937021

DOI: 10.1124/jpet.116.232637

Sequence Information:

  • Length: 497
  • Mass: 56199
  • Checksum: 834318FA493E76D4
  • Sequence:
    • MGLPALLASA LCTFVLPLLL FLAAIKLWDL YCVSGRDRSC ALPLPPGTMG FPFFGETLQM 
VLQRRKFLQM KRRKYGFIYK THLFGRPTVR VMGADNVRRI LLGEHRLVSV HWPASVRTIL 
GSGCLSNLHD SSHKQRKKVI MRAFSREALE CYVPVITEEV GSSLEQWLSC GERGLLVYPE 
VKRLMFRIAM RILLGCEPQL AGDGDSEQQL VEAFEEMTRN LFSLPIDVPF SGLYRGMKAR 
NLIHARIEQN IRAKICGLRA SEAGQGCKDA LQLLIEHSWE RGERLDMQAL KQSSTELLFG 
GHETTASAAT SLITYLGLYP HVLQKVREEL KSKGLLCKSN QDNKLDMEIL EQLKYIGCVI 
KETLRLNPPV PGGFRVALKT FELNGYQIPK GWNVIYSICD THDVAEIFTN KEEFNPDRFM 
LPHPEDASRF SFIPFGGGLR SCVGKEFAKI LLKIFTVELA RHCDWQLLNG PPTMKTSPTV 
YPVDNLPARF THFHGEI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.