Details for: ENPP3

Gene ID: 5169

Symbol: ENPP3

Ensembl ID: ENSG00000154269

Description: ectonucleotide pyrophosphatase/phosphodiesterase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 20.9585
    Cell Significance Index: -3.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 12.9315
    Cell Significance Index: -3.2800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 7.4583
    Cell Significance Index: -3.0300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 6.0583
    Cell Significance Index: 162.3400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.5144
    Cell Significance Index: 215.4700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.7599
    Cell Significance Index: 29.6000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3849
    Cell Significance Index: 263.5600
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 1.1292
    Cell Significance Index: 11.3000
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.1184
    Cell Significance Index: 6.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0008
    Cell Significance Index: 198.6200
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 0.9863
    Cell Significance Index: 5.4900
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.8708
    Cell Significance Index: 7.7300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.8332
    Cell Significance Index: 17.8100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8100
    Cell Significance Index: 48.6300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.6075
    Cell Significance Index: 8.8200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5234
    Cell Significance Index: 472.5900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5204
    Cell Significance Index: 56.6100
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.4220
    Cell Significance Index: 3.4900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3244
    Cell Significance Index: 22.4400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.3210
    Cell Significance Index: 4.6000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2913
    Cell Significance Index: 47.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2742
    Cell Significance Index: 12.4300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.2048
    Cell Significance Index: 2.1200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1623
    Cell Significance Index: 3.7500
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.1622
    Cell Significance Index: 1.2400
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.1328
    Cell Significance Index: 1.3700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1325
    Cell Significance Index: 2.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1239
    Cell Significance Index: 3.5700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1209
    Cell Significance Index: 1.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1019
    Cell Significance Index: 20.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0995
    Cell Significance Index: 35.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0915
    Cell Significance Index: 9.0500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0850
    Cell Significance Index: 1.1600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0789
    Cell Significance Index: 3.6800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0629
    Cell Significance Index: 2.2100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0617
    Cell Significance Index: 1.3500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0611
    Cell Significance Index: 0.8700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0473
    Cell Significance Index: 6.8800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0406
    Cell Significance Index: 1.3000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0378
    Cell Significance Index: 0.5700
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: 0.0329
    Cell Significance Index: 0.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0243
    Cell Significance Index: 0.6800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0241
    Cell Significance Index: 0.4700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0209
    Cell Significance Index: 11.4300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0200
    Cell Significance Index: 0.5000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0162
    Cell Significance Index: 30.5000
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.0161
    Cell Significance Index: 0.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0145
    Cell Significance Index: 0.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0111
    Cell Significance Index: 2.0000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0082
    Cell Significance Index: 1.1300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0070
    Cell Significance Index: 0.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0060
    Cell Significance Index: 9.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0051
    Cell Significance Index: 9.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0047
    Cell Significance Index: 2.9800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0042
    Cell Significance Index: 0.0900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0039
    Cell Significance Index: 0.5000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0011
    Cell Significance Index: 0.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0009
    Cell Significance Index: 1.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0038
    Cell Significance Index: -2.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0039
    Cell Significance Index: -2.9700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0041
    Cell Significance Index: -2.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0051
    Cell Significance Index: -0.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0053
    Cell Significance Index: -3.0000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0056
    Cell Significance Index: -3.5100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0060
    Cell Significance Index: -2.6400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0061
    Cell Significance Index: -0.1300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0062
    Cell Significance Index: -1.7900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0063
    Cell Significance Index: -0.7400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0070
    Cell Significance Index: -0.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0083
    Cell Significance Index: -0.8500
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0087
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0089
    Cell Significance Index: -1.5200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0092
    Cell Significance Index: -1.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0104
    Cell Significance Index: -1.2800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0108
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0150
    Cell Significance Index: -3.1600
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0161
    Cell Significance Index: -0.1000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0172
    Cell Significance Index: -0.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0189
    Cell Significance Index: -1.4100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0225
    Cell Significance Index: -0.1800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0228
    Cell Significance Index: -0.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0229
    Cell Significance Index: -2.3800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0239
    Cell Significance Index: -2.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0243
    Cell Significance Index: -1.5300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0257
    Cell Significance Index: -2.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0302
    Cell Significance Index: -2.3200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0305
    Cell Significance Index: -0.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0324
    Cell Significance Index: -2.1800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0354
    Cell Significance Index: -1.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0413
    Cell Significance Index: -2.3200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0432
    Cell Significance Index: -2.2700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.0432
    Cell Significance Index: -0.9000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0437
    Cell Significance Index: -3.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0474
    Cell Significance Index: -2.2300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0490
    Cell Significance Index: -0.6800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0502
    Cell Significance Index: -1.6000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0508
    Cell Significance Index: -1.0200
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0521
    Cell Significance Index: -0.5900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0525
    Cell Significance Index: -1.2600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0532
    Cell Significance Index: -0.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ENPP3 is a glycoprotein enzyme that is characterized by its ability to bind to extracellular nucleotides and pyrophosphates, and to hydrolyze them into nucleosides and inorganic pyrophosphate. The enzyme is a member of the ectonucleotide pyrophosphatase/phosphodiesterase family and is known to be involved in various cellular processes, including: * Nucleotide metabolism: ENPP3 is involved in the hydrolysis of nucleotides, leading to the production of nucleosides and inorganic pyrophosphate. * Immune response: ENPP3 is involved in the regulation of immune responses, including the activation of basophils and the regulation of mast cell activation. * Cell signaling: ENPP3 is involved in cell signaling pathways, including the regulation of calcium ion binding and the modulation of phosphodiesterase activity. * Metabolism: ENPP3 is involved in the metabolism of various compounds, including inorganic diphosphate, nucleoside triphosphate, and pyrimidine nucleotides. **Pathways and Functions** ENPP3 is involved in various cellular pathways, including: * **Apical plasma membrane pathway**: ENPP3 is localized to the apical plasma membrane and is involved in the regulation of calcium ion binding and the modulation of phosphodiesterase activity. * **ATP metabolic process pathway**: ENPP3 is involved in the hydrolysis of ATP, leading to the production of ADP and inorganic pyrophosphate. * **Basophil activation involved in immune response pathway**: ENPP3 is involved in the regulation of basophil activation, leading to the production of pro-inflammatory cytokines. * **Negative regulation of inflammatory response pathway**: ENPP3 is involved in the negative regulation of inflammatory responses, including the regulation of mast cell activation and proliferation. * **Nucleoside triphosphate catabolic process pathway**: ENPP3 is involved in the hydrolysis of nucleoside triphosphates, leading to the production of nucleosides and inorganic pyrophosphate. **Clinical Significance** ENPP3 has been implicated in various diseases and disorders, including: * **Migraine**: ENPP3 has been shown to be involved in the pathophysiology of migraine, and has been proposed as a potential therapeutic target. * **Inflammatory disorders**: ENPP3 has been shown to be involved in the regulation of inflammatory responses, and has been proposed as a potential therapeutic target for inflammatory disorders. * **Neurodegenerative disorders**: ENPP3 has been shown to be involved in the regulation of cell signaling pathways, and has been proposed as a potential therapeutic target for neurodegenerative disorders. * **Cancer**: ENPP3 has been shown to be involved in the regulation of cell signaling pathways, and has been proposed as a potential therapeutic target for cancer. In conclusion, ENPP3 is a multifunctional enzyme that plays a crucial role in various cellular processes, including immune response, metabolism, and cell signaling. Its involvement in various diseases and disorders has significant clinical implications, and further research is needed to fully understand its role in human health and disease.

Genular Protein ID: 3679958556

Symbol: ENPP3_HUMAN

Name: Phosphodiesterase I/nucleotide pyrophosphatase 3

UniProtKB Accession Codes:

O14638 Q5JTL3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 67 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 6 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 25 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 19 SABIO-RK 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9344668

Title: Molecular cloning and chromosomal localization of PD-Ibeta (PDNP3), a new member of the human phosphodiesterase I genes.

PubMed ID: 9344668

DOI: 10.1006/geno.1997.4949

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 11342463

Title: The basophil activation marker defined by antibody 97A6 is identical to the ectonucleotide pyrophosphatase/phosphodiesterase 3.

PubMed ID: 11342463

DOI: 10.1182/blood.v97.10.3303

PubMed ID: 12846830

Title: Hydrolysis of diadenosine polyphosphates by nucleotide pyrophosphatases/phosphodiesterases.

PubMed ID: 12846830

DOI: 10.1046/j.1432-1033.2003.03674.x

PubMed ID: 15072822

Title: Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-1 (E-NPP1/PC-1) and -3 (E-NPP3/CD203c/PD-Ibeta/B10/gp130(RB13-6)) in inflammatory and neoplastic bile duct diseases.

PubMed ID: 15072822

DOI: 10.1016/j.canlet.2003.11.002

PubMed ID: 15031605

Title: The basophil-specific ectoenzyme E-NPP3 (CD203c) as a marker for cell activation and allergy diagnosis.

PubMed ID: 15031605

DOI: 10.1159/000077351

PubMed ID: 29717535

Title: Structural basis for nucleotide recognition by the ectoenzyme CD203c.

PubMed ID: 29717535

DOI: 10.1111/febs.14489

Sequence Information:

  • Length: 875
  • Mass: 100124
  • Checksum: 629D2E33B4C45196
  • Sequence:
    • MESTLTLATE QPVKKNTLKK YKIACIVLLA LLVIMSLGLG LGLGLRKLEK QGSCRKKCFD 
ASFRGLENCR CDVACKDRGD CCWDFEDTCV ESTRIWMCNK FRCGETRLEA SLCSCSDDCL 
QRKDCCADYK SVCQGETSWL EENCDTAQQS QCPEGFDLPP VILFSMDGFR AEYLYTWDTL 
MPNINKLKTC GIHSKYMRAM YPTKTFPNHY TIVTGLYPES HGIIDNNMYD VNLNKNFSLS 
SKEQNNPAWW HGQPMWLTAM YQGLKAATYF WPGSEVAING SFPSIYMPYN GSVPFEERIS 
TLLKWLDLPK AERPRFYTMY FEEPDSSGHA GGPVSARVIK ALQVVDHAFG MLMEGLKQRN 
LHNCVNIILL ADHGMDQTYC NKMEYMTDYF PRINFFYMYE GPAPRIRAHN IPHDFFSFNS 
EEIVRNLSCR KPDQHFKPYL TPDLPKRLHY AKNVRIDKVH LFVDQQWLAV RSKSNTNCGG 
GNHGYNNEFR SMEAIFLAHG PSFKEKTEVE PFENIEVYNL MCDLLRIQPA PNNGTHGSLN 
HLLKVPFYEP SHAEEVSKFS VCGFANPLPT ESLDCFCPHL QNSTQLEQVN QMLNLTQEEI 
TATVKVNLPF GRPRVLQKNV DHCLLYHREY VSGFGKAMRM PMWSSYTVPQ LGDTSPLPPT 
VPDCLRADVR VPPSESQKCS FYLADKNITH GFLYPPASNR TSDSQYDALI TSNLVPMYEE 
FRKMWDYFHS VLLIKHATER NGVNVVSGPI FDYNYDGHFD APDEITKHLA NTDVPIPTHY 
FVVLTSCKNK SHTPENCPGW LDVLPFIIPH RPTNVESCPE GKPEALWVEE RFTAHIARVR 
DVELLTGLDF YQDKVQPVSE ILQLKTYLPT FETTI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.