Details for: EPHX1

Gene ID: 2052

Symbol: EPHX1

Ensembl ID: ENSG00000143819

Description: epoxide hydrolase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.44
    Marker Score: 61147
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.29
    Marker Score: 24519
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.93
    Marker Score: 25451
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.47
    Marker Score: 8078
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.42
    Marker Score: 2605
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 2.39
    Marker Score: 656
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.32
    Marker Score: 80273
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.18
    Marker Score: 3153
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.15
    Marker Score: 495
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.14
    Marker Score: 619
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.14
    Marker Score: 13957
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.13
    Marker Score: 2492
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.1
    Marker Score: 13655
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.07
    Marker Score: 5422
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.07
    Marker Score: 3780
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.07
    Marker Score: 20834.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.97
    Marker Score: 4490
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.92
    Marker Score: 5238
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.92
    Marker Score: 40935
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.92
    Marker Score: 16516
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.9
    Marker Score: 2795
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.88
    Marker Score: 3022
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.85
    Marker Score: 3523.5
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.85
    Marker Score: 1325
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.83
    Marker Score: 3867
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.83
    Marker Score: 9603
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.68
    Marker Score: 1750
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.67
    Marker Score: 3328
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.65
    Marker Score: 1733
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.64
    Marker Score: 2859.5
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.62
    Marker Score: 892
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.61
    Marker Score: 25918
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.59
    Marker Score: 393
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.59
    Marker Score: 1121
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.59
    Marker Score: 404
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.59
    Marker Score: 741
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.57
    Marker Score: 12264
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.57
    Marker Score: 2655
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.56
    Marker Score: 1922
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.55
    Marker Score: 3774.5
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.53
    Marker Score: 8246
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.52
    Marker Score: 1015
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.52
    Marker Score: 781
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.52
    Marker Score: 565
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.51
    Marker Score: 3850
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.51
    Marker Score: 9727
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.47
    Marker Score: 699
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167120
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.46
    Marker Score: 1879
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.45
    Marker Score: 715
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.45
    Marker Score: 357
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.42
    Marker Score: 6141
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.42
    Marker Score: 450
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.41
    Marker Score: 1956
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.4
    Marker Score: 1247
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.4
    Marker Score: 1101
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.39
    Marker Score: 1345
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.38
    Marker Score: 4757
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.36
    Marker Score: 3209
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.36
    Marker Score: 5846
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.33
    Marker Score: 284
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.33
    Marker Score: 321
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.32
    Marker Score: 1404
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.32
    Marker Score: 7808
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.31
    Marker Score: 1129
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.31
    Marker Score: 2084
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.28
    Marker Score: 1073
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.26
    Marker Score: 1076
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.26
    Marker Score: 524
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.23
    Marker Score: 315
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.23
    Marker Score: 2024.5
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.21
    Marker Score: 797
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.2
    Marker Score: 1295.5
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.2
    Marker Score: 4426
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.19
    Marker Score: 4235
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.19
    Marker Score: 277
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.19
    Marker Score: 1370
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.19
    Marker Score: 1064
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.18
    Marker Score: 1068
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.14
    Marker Score: 721.5
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.14
    Marker Score: 444
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.13
    Marker Score: 485
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.13
    Marker Score: 547
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.11
    Marker Score: 417
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.1
    Marker Score: 1040
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1
    Marker Score: 12414
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.1
    Marker Score: 343
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.09
    Marker Score: 458
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.09
    Marker Score: 566
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.09
    Marker Score: 262
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.08
    Marker Score: 2037
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.08
    Marker Score: 633
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.08
    Marker Score: 939
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.06
    Marker Score: 4154
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.06
    Marker Score: 734
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.05
    Marker Score: 719
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.04
    Marker Score: 1219
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251702
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.03
    Marker Score: 413
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.03
    Marker Score: 3983

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Other Information

**Key characteristics**: * EPHX1 is a protein of approximately 110 kDa. * It is expressed in a variety of cell types, including epithelial cells, endothelial cells, and immune cells. * It is found in the endoplasmic reticulum, where it is primarily produced. * It is a key enzyme in the arachidonic acid metabolic process, which is involved in the metabolism of cholesterol and other lipids. * It is also involved in the aromatic compound catabolic process, the biological oxidation of drugs, and the detoxification of reactive oxygen species. **Pathways and functions**: * EPHX1 is involved in a variety of cellular processes, including: * The metabolism of various organic compounds, including cholesterol, fatty acids, and drugs. * The detoxification of reactive oxygen species. * The regulation of cell growth and differentiation. * The production of epoxides, which are involved in a variety of biological processes, including cell signaling, DNA repair, and lipid metabolism. **Clinical significance**: * Mutations in the EPHX1 gene have been linked to a number of human diseases, including: * Cardiovascular disease * Cancer * Diabetes * Metabolic disorders * Kidney disease **Additional information**: * EPHX1 is a highly conserved protein, with similar sequences found in organisms from yeast to humans. * It is a member of the epoxide hydrolase family of enzymes, which are involved in the metabolism of epoxides. * It is a well-characterized protein that has been extensively studied in research on human health and disease.

Genular Protein ID: 1655687768

Symbol: HYEP_HUMAN

Name: Epoxide hydratase

UniProtKB Accession Codes:

P07099 B2R8N0 Q5VTJ6 Q9NP75 Q9NPE7 Q9NQU6 Q9NQU7 Q9NQU8 Q9NQU9 Q9NQV0 Q9NQV1 Q9NQV2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 3 CTD 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 2 EMBL 32 EPD 1 ESTHER 1 Ensembl 3 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 9 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2891713

Title: Human microsomal xenobiotic epoxide hydrolase. Complementary DNA sequence, complementary DNA-directed expression in COS-1 cells, and chromosomal localization.

PubMed ID: 2891713

DOI: 10.1016/s0021-9258(19)57339-2

PubMed ID: 3502697

Title: Nucleotide and deduced amino acid sequence of human liver microsomal epoxide hydrolase.

PubMed ID: 3502697

DOI: 10.1093/nar/15.17.7188

PubMed ID: 7516776

Title: Human microsomal epoxide hydrolase: genetic polymorphism and functional expression in vitro of amino acid variants.

PubMed ID: 7516776

DOI: 10.1093/hmg/3.3.421

PubMed ID: 7835893

Title: The human microsomal epoxide hydrolase gene (EPHX1): complete nucleotide sequence and structural characterization.

PubMed ID: 7835893

DOI: 10.1006/geno.1994.1520

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11058921

Title: Identification of 6 new polymorphisms, g.11177G>A, g.14622C>T (R49C), g.17540T>C, g.17639T>C, g.30929T>C, g.31074G>A (R454Q), in the human microsomal epoxide hydrolase gene (EPHX1) in a French population.

PubMed ID: 11058921

DOI: 10.1002/1098-1004(200011)16:5<450::aid-humu28>3.0.co;2-1

PubMed ID: 12878321

Title: Inhibition of human m-epoxide hydrolase gene expression in a case of hypercholanemia.

PubMed ID: 12878321

DOI: 10.1016/s0925-4439(03)00085-1

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22798687

Title: EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides.

PubMed ID: 22798687

DOI: 10.1194/jlr.m024448

PubMed ID: 24958911

Title: A novel activity of microsomal epoxide hydrolase: metabolism of the endocannabinoid 2-arachidonoylglycerol.

PubMed ID: 24958911

DOI: 10.1194/jlr.m051284

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 12173035

Title: Two exonic single nucleotide polymorphisms in the microsomal epoxide hydrolase gene are jointly associated with preeclampsia.

PubMed ID: 12173035

DOI: 10.1038/sj.ejhg.5200849

PubMed ID: 15618730

Title: Five novel single nucleotide polymorphisms in the EPHX1 gene encoding microsomal epoxide hydrolase.

PubMed ID: 15618730

DOI: 10.2133/dmpk.18.150

PubMed ID: 15535985

Title: Functional analysis of human microsomal epoxide hydrolase genetic variants.

PubMed ID: 15535985

DOI: 10.1016/j.cbi.2004.07.004

Sequence Information:

  • Length: 455
  • Mass: 52949
  • Checksum: 88E333838C841390
  • Sequence:
    • MWLEILLTSV LGFAIYWFIS RDKEETLPLE DGWWGPGTRS AAREDDSIRP FKVETSDEEI 
HDLHQRIDKF RFTPPLEDSC FHYGFNSNYL KKVISYWRNE FDWKKQVEIL NRYPHFKTKI 
EGLDIHFIHV KPPQLPAGHT PKPLLMVHGW PGSFYEFYKI IPLLTDPKNH GLSDEHVFEV 
ICPSIPGYGF SEASSKKGFN SVATARIFYK LMLRLGFQEF YIQGGDWGSL ICTNMAQLVP 
SHVKGLHLNM ALVLSNFSTL TLLLGQRFGR FLGLTERDVE LLYPVKEKVF YSLMRESGYM 
HIQCTKPDTV GSALNDSPVG LAAYILEKFS TWTNTEFRYL EDGGLERKFS LDDLLTNVML 
YWTTGTIISS QRFYKENLGQ GWMTQKHERM KVYVPTGFSA FPFELLHTPE KWVRFKYPKL 
ISYSYMVRGG HFAAFEEPEL LAQDIRKFLS VLERQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.