Details for: EPHX1

Gene ID: 2052

Symbol: EPHX1

Ensembl ID: ENSG00000143819

Description: epoxide hydrolase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 284.2260
    Cell Significance Index: -44.2100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 177.8087
    Cell Significance Index: -45.1000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 92.6454
    Cell Significance Index: -43.7400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 90.5584
    Cell Significance Index: -36.7900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 38.3035
    Cell Significance Index: -36.5700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 36.4733
    Cell Significance Index: -44.9700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.4884
    Cell Significance Index: -44.1700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.1960
    Cell Significance Index: -44.1800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.9329
    Cell Significance Index: -33.5800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 7.7466
    Cell Significance Index: 65.0700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 6.6488
    Cell Significance Index: 178.1600
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 6.5246
    Cell Significance Index: 32.5500
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 6.0177
    Cell Significance Index: 37.2300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.9903
    Cell Significance Index: 104.9300
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.5523
    Cell Significance Index: 20.8700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.6275
    Cell Significance Index: 33.6500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.0763
    Cell Significance Index: 1133.9300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.0556
    Cell Significance Index: 36.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.9029
    Cell Significance Index: 377.6300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.5526
    Cell Significance Index: 72.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.4978
    Cell Significance Index: 270.0000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.4720
    Cell Significance Index: 13.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2270
    Cell Significance Index: 63.7400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1433
    Cell Significance Index: 68.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1313
    Cell Significance Index: 139.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.0357
    Cell Significance Index: 176.8600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9644
    Cell Significance Index: 870.8100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9601
    Cell Significance Index: 131.8500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.8086
    Cell Significance Index: 13.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.7124
    Cell Significance Index: 83.0300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6511
    Cell Significance Index: 46.0500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6310
    Cell Significance Index: 32.8700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5984
    Cell Significance Index: 11.6800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5793
    Cell Significance Index: 94.2100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5559
    Cell Significance Index: 245.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5184
    Cell Significance Index: 11.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4621
    Cell Significance Index: 34.4400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4600
    Cell Significance Index: 12.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4464
    Cell Significance Index: 44.1600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3890
    Cell Significance Index: 49.8700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3807
    Cell Significance Index: 26.3300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3027
    Cell Significance Index: 8.4600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2775
    Cell Significance Index: 14.0300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.2704
    Cell Significance Index: 4.5600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.2619
    Cell Significance Index: 3.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2158
    Cell Significance Index: 9.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1699
    Cell Significance Index: 4.9000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1555
    Cell Significance Index: 29.5900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1241
    Cell Significance Index: 93.9600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1020
    Cell Significance Index: 4.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0779
    Cell Significance Index: 10.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0402
    Cell Significance Index: 14.4300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0255
    Cell Significance Index: 16.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0253
    Cell Significance Index: 0.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0004
    Cell Significance Index: 0.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0045
    Cell Significance Index: -6.9900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0046
    Cell Significance Index: -8.4300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0057
    Cell Significance Index: -10.6600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0271
    Cell Significance Index: -20.0500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0285
    Cell Significance Index: -19.7200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0298
    Cell Significance Index: -18.6300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0309
    Cell Significance Index: -22.6700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0311
    Cell Significance Index: -0.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0366
    Cell Significance Index: -49.7900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0388
    Cell Significance Index: -3.9600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0452
    Cell Significance Index: -1.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0529
    Cell Significance Index: -29.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0812
    Cell Significance Index: -36.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1161
    Cell Significance Index: -33.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1248
    Cell Significance Index: -14.3000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1288
    Cell Significance Index: -1.0500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1319
    Cell Significance Index: -15.0600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1509
    Cell Significance Index: -31.7900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1858
    Cell Significance Index: -5.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2254
    Cell Significance Index: -32.7700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2771
    Cell Significance Index: -3.7800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2876
    Cell Significance Index: -6.0200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3653
    Cell Significance Index: -43.0800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3787
    Cell Significance Index: -8.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4024
    Cell Significance Index: -30.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4143
    Cell Significance Index: -27.8600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4197
    Cell Significance Index: -43.7100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4216
    Cell Significance Index: -26.5700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4237
    Cell Significance Index: -9.7900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4515
    Cell Significance Index: -27.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4773
    Cell Significance Index: -37.8000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.5765
    Cell Significance Index: -8.9200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.5787
    Cell Significance Index: -14.1200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5837
    Cell Significance Index: -37.6600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5875
    Cell Significance Index: -36.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.6060
    Cell Significance Index: -16.1800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6087
    Cell Significance Index: -31.9600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6361
    Cell Significance Index: -16.3500
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.6815
    Cell Significance Index: -7.0300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.7200
    Cell Significance Index: -8.1800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.7519
    Cell Significance Index: -11.3300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7822
    Cell Significance Index: -27.1800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7937
    Cell Significance Index: -44.5400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.8743
    Cell Significance Index: -24.9500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.9467
    Cell Significance Index: -15.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** EPHX1 is a member of the epoxide hydrolase family, characterized by its ability to catalyze the hydrolysis of epoxides to diols. This reaction is essential for the degradation of various xenobiotics, including pesticides, industrial chemicals, and pharmaceuticals. EPHX1 is primarily expressed in cells involved in detoxification, such as the liver, kidneys, and adrenal gland, where it plays a crucial role in the metabolism of endogenous and exogenous compounds. **Pathways and Functions** EPHX1 is involved in several metabolic pathways, including: 1. **Arachidonic acid metabolic process**: EPHX1 is required for the degradation of arachidonic acid, a polyunsaturated fatty acid involved in inflammation and immune responses. 2. **Aromatic compound catabolic process**: EPHX1 is responsible for the metabolism of aromatic compounds, including pesticides and industrial chemicals. 3. **Biological oxidations**: EPHX1 participates in the oxidation of various substrates, including steroids and fatty acids. 4. **Cis-stilbene-oxide hydrolase activity**: EPHX1 is involved in the degradation of cis-stilbene-oxide, a compound found in certain pesticides. EPHX1 functions as a cytochrome P450 reductase, working in conjunction with other enzymes to facilitate the metabolism of xenobiotics. Its activity is essential for maintaining cellular homeostasis and preventing oxidative damage. **Clinical Significance** Dysregulation of EPHX1 has been implicated in various diseases, including: 1. **Cancer**: EPHX1 has been shown to be involved in the metabolism of carcinogenic compounds, and its polymorphisms have been associated with increased cancer risk. 2. **Neurological disorders**: EPHX1 is involved in the metabolism of neuroactive compounds, and its dysregulation has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Environmental toxicology**: EPHX1 is essential for the detoxification of environmental pollutants, and its dysregulation can lead to increased susceptibility to toxic substances. In conclusion, EPHX1 is a critical enzyme involved in the metabolism of xenobiotics and the maintenance of cellular homeostasis. Its dysregulation has significant clinical implications, and further research is needed to fully understand its role in human health and disease.

Genular Protein ID: 1655687768

Symbol: HYEP_HUMAN

Name: Epoxide hydratase

UniProtKB Accession Codes:

P07099 B2R8N0 Q5VTJ6 Q9NP75 Q9NPE7 Q9NQU6 Q9NQU7 Q9NQU8 Q9NQU9 Q9NQV0 Q9NQV1 Q9NQV2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 3 CTD 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 2 EMBL 32 ESTHER 1 Ensembl 3 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 9 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2891713

Title: Human microsomal xenobiotic epoxide hydrolase. Complementary DNA sequence, complementary DNA-directed expression in COS-1 cells, and chromosomal localization.

PubMed ID: 2891713

DOI: 10.1016/s0021-9258(19)57339-2

PubMed ID: 3502697

Title: Nucleotide and deduced amino acid sequence of human liver microsomal epoxide hydrolase.

PubMed ID: 3502697

DOI: 10.1093/nar/15.17.7188

PubMed ID: 7516776

Title: Human microsomal epoxide hydrolase: genetic polymorphism and functional expression in vitro of amino acid variants.

PubMed ID: 7516776

DOI: 10.1093/hmg/3.3.421

PubMed ID: 7835893

Title: The human microsomal epoxide hydrolase gene (EPHX1): complete nucleotide sequence and structural characterization.

PubMed ID: 7835893

DOI: 10.1006/geno.1994.1520

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11058921

Title: Identification of 6 new polymorphisms, g.11177G>A, g.14622C>T (R49C), g.17540T>C, g.17639T>C, g.30929T>C, g.31074G>A (R454Q), in the human microsomal epoxide hydrolase gene (EPHX1) in a French population.

PubMed ID: 11058921

DOI: 10.1002/1098-1004(200011)16:5<450::aid-humu28>3.0.co;2-1

PubMed ID: 12878321

Title: Inhibition of human m-epoxide hydrolase gene expression in a case of hypercholanemia.

PubMed ID: 12878321

DOI: 10.1016/s0925-4439(03)00085-1

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22798687

Title: EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides.

PubMed ID: 22798687

DOI: 10.1194/jlr.m024448

PubMed ID: 24958911

Title: A novel activity of microsomal epoxide hydrolase: metabolism of the endocannabinoid 2-arachidonoylglycerol.

PubMed ID: 24958911

DOI: 10.1194/jlr.m051284

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 12173035

Title: Two exonic single nucleotide polymorphisms in the microsomal epoxide hydrolase gene are jointly associated with preeclampsia.

PubMed ID: 12173035

DOI: 10.1038/sj.ejhg.5200849

PubMed ID: 15618730

Title: Five novel single nucleotide polymorphisms in the EPHX1 gene encoding microsomal epoxide hydrolase.

PubMed ID: 15618730

DOI: 10.2133/dmpk.18.150

PubMed ID: 15535985

Title: Functional analysis of human microsomal epoxide hydrolase genetic variants.

PubMed ID: 15535985

DOI: 10.1016/j.cbi.2004.07.004

Sequence Information:

  • Length: 455
  • Mass: 52949
  • Checksum: 88E333838C841390
  • Sequence:
    • MWLEILLTSV LGFAIYWFIS RDKEETLPLE DGWWGPGTRS AAREDDSIRP FKVETSDEEI 
HDLHQRIDKF RFTPPLEDSC FHYGFNSNYL KKVISYWRNE FDWKKQVEIL NRYPHFKTKI 
EGLDIHFIHV KPPQLPAGHT PKPLLMVHGW PGSFYEFYKI IPLLTDPKNH GLSDEHVFEV 
ICPSIPGYGF SEASSKKGFN SVATARIFYK LMLRLGFQEF YIQGGDWGSL ICTNMAQLVP 
SHVKGLHLNM ALVLSNFSTL TLLLGQRFGR FLGLTERDVE LLYPVKEKVF YSLMRESGYM 
HIQCTKPDTV GSALNDSPVG LAAYILEKFS TWTNTEFRYL EDGGLERKFS LDDLLTNVML 
YWTTGTIISS QRFYKENLGQ GWMTQKHERM KVYVPTGFSA FPFELLHTPE KWVRFKYPKL 
ISYSYMVRGG HFAAFEEPEL LAQDIRKFLS VLERQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.